path.names	p.value	UP/DOWN	statistic	FDRp.value	path.name
P-hsa04261-39	Adrenergic signaling in cardiomyocytes: SCN1B	8.10282747417443e-42	DOWN	-13.5487583124773	1.04283389592625e-38	Adrenergic signaling in cardiomyocytes: SCN1B
P-hsa03320-32	PPAR signaling pathway: FABP3	2.1613984485638e-41	DOWN	-13.476539381543	1.3908599016508e-38	PPAR signaling pathway: FABP3
P-hsa04261-23	Adrenergic signaling in cardiomyocytes: SLC9A1	1.82156645899181e-40	DOWN	-13.3183068924172	7.81452010907488e-38	Adrenergic signaling in cardiomyocytes: SLC9A1
P-hsa04910-14	Insulin signaling pathway: C00369	2.46876401650336e-40	UP	13.295586329876	7.94324822309957e-38	Insulin signaling pathway: C00369
P-hsa04727-47	GABAergic synapse: CACNA1A*	6.53681587654248e-40	UP	13.2225559502795	1.6483548459677e-37	GABAergic synapse: CACNA1A*
P-hsa04922-37	Glucagon signaling pathway: PYGB	7.68463797653939e-40	DOWN	-13.2103842203468	1.6483548459677e-37	Glucagon signaling pathway: PYGB
P-hsa04922-17	Glucagon signaling pathway: PKM	1.05020115497291e-39	UP	13.1868522091435	1.93086983778592e-37	Glucagon signaling pathway: PKM
P-hsa04922-70	Glucagon signaling pathway: PFKFB1	1.49741051205076e-39	DOWN	-13.1600744032914	2.40895916126165e-37	Glucagon signaling pathway: PFKFB1
P-hsa04261-72	Adrenergic signaling in cardiomyocytes: ATP2B1	2.34952484527488e-39	DOWN	-13.1259935594797	3.35982052874308e-37	Adrenergic signaling in cardiomyocytes: ATP2B1
P-hsa04727-26	GABAergic synapse: KCNJ6	5.64282480279561e-39	DOWN	-13.0594547691807	7.26231552119795e-37	GABAergic synapse: KCNJ6
P-hsa04310-57	Wnt signaling pathway: SIAH1	1.58179894608955e-38	UP	12.9807442489489	1.85070476692477e-36	Wnt signaling pathway: SIAH1
P-hsa04010-107	MAPK signaling pathway: MAP3K2	2.36478616870897e-38	DOWN	-12.9499091997859	2.53623316594037e-36	MAPK signaling pathway: MAP3K2
P-hsa04728-61	Dopaminergic synapse: KCNJ3	2.86004636810169e-38	DOWN	-12.9353031238666	2.83144590442067e-36	Dopaminergic synapse: KCNJ3
P-hsa04261-73	Adrenergic signaling in cardiomyocytes: KCNE1	3.88353123283139e-38	DOWN	-12.9117711126633	3.33206979776934e-36	Adrenergic signaling in cardiomyocytes: KCNE1
P-hsa04919-99	Thyroid hormone signaling pathway: WNT4	3.88353123283139e-38	DOWN	-12.9117711126633	3.33206979776934e-36	Thyroid hormone signaling pathway: WNT4
P-hsa04261-20	Adrenergic signaling in cardiomyocytes: ATP1B4	4.69426363057333e-38	DOWN	-12.897165036744	3.77594830784242e-36	Adrenergic signaling in cardiomyocytes: ATP1B4
P-hsa04970-18	Salivary secretion: VAMP2	1.93279812995751e-37	DOWN	-12.7876194673492	1.3964517700435e-35	Salivary secretion: VAMP2
P-hsa04066-50	HIF-1 signaling pathway: TF	1.95307939866224e-37	DOWN	-12.786808018687	1.3964517700435e-35	HIF-1 signaling pathway: TF
P-hsa04530-11 33	Tight junction: TJP1 CGN	5.30399341866004e-37	DOWN	-12.7089089471174	3.5927576472713e-35	Tight junction: TJP1 CGN
P-hsa04530-22 33	Tight junction: MYL12B CGN	6.19670129892822e-37	DOWN	-12.6967372171847	3.98757728586031e-35	Tight junction: MYL12B CGN
P-hsa04211-39	Longevity regulating pathway - mammal: TP53*	1.4920344190227e-36	UP	12.6277640808991	9.14403951086769e-35	Longevity regulating pathway - mammal: TP53*
P-hsa04728-54	Dopaminergic synapse: CAMK2A	4.81251709403783e-36	DOWN	-12.5352589334101	2.81532250001213e-34	Dopaminergic synapse: CAMK2A
P-hsa04024-34	cAMP signaling pathway: ATP2B1	6.67530995290135e-36	DOWN	-12.5092925762203	3.73527126494958e-34	cAMP signaling pathway: ATP2B1
P-hsa04742-48	Taste transduction: GABBR1	7.9404157151246e-36	DOWN	-12.4954979489632	4.25804792723557e-34	Taste transduction: GABBR1
P-hsa04261-4	Adrenergic signaling in cardiomyocytes: SLC8A1	1.36238152412076e-35	DOWN	-12.4524911698674	7.01354008617366e-34	Adrenergic signaling in cardiomyocytes: SLC8A1
P-hsa04931-87	Insulin resistance: C00031*	2.10829221393476e-35	DOWN	-12.4175988773935	1.04360464589771e-33	Insulin resistance: C00031*
P-hsa04727-13	GABAergic synapse: CACNA1A	4.15295128895811e-35	UP	12.3632318170273	1.9795734477367e-33	GABAergic synapse: CACNA1A
P-hsa04014-24	Ras signaling pathway: PLD1	5.97075242045024e-35	DOWN	-12.3340196651886	2.74441370182838e-33	Ras signaling pathway: PLD1
P-hsa04151-63	PI3K-Akt signaling pathway: CASP9	6.6701136601591e-35	DOWN	-12.3250937299046	2.96015044159475e-33	PI3K-Akt signaling pathway: CASP9
P-hsa04668-141	TNF signaling pathway: JUN*	1.21874933988222e-34	DOWN	-12.2764068101736	5.2284346680947e-33	TNF signaling pathway: JUN*
P-hsa04261-36	Adrenergic signaling in cardiomyocytes: MAPK1	1.26861575592087e-34	DOWN	-12.2731610155249	5.26680154151664e-33	Adrenergic signaling in cardiomyocytes: MAPK1
P-hsa04062-44	Chemokine signaling pathway: MAPK1	1.51930345757973e-34	DOWN	-12.2585549396056	5.98490464519768e-33	Chemokine signaling pathway: MAPK1
P-hsa04210-58	Apoptosis: BID*	1.53459093466607e-34	UP	12.2577434909434	5.98490464519768e-33	Apoptosis: BID*
P-hsa04062-33	Chemokine signaling pathway: WAS	3.24556669196252e-34	DOWN	-12.1968848412796	1.2285424507517e-32	Chemokine signaling pathway: WAS
P-hsa04012-37 7	ErbB signaling pathway: ERBB3 ERBB3	3.80610345003635e-34	DOWN	-12.1839016626847	1.39955861148479e-32	ErbB signaling pathway: ERBB3 ERBB3
P-hsa04919-84	Thyroid hormone signaling pathway: TP53*	4.24625975793449e-34	UP	12.1749757274007	1.51803786346158e-32	Thyroid hormone signaling pathway: TP53*
P-hsa04911-31	Insulin secretion: CAMK2A	4.73694291178667e-34	DOWN	-12.1660497921167	1.64768798039715e-32	Insulin secretion: CAMK2A
P-hsa04973-36	Carbohydrate digestion and absorption: SLC2A2	4.97821758202248e-34	DOWN	-12.1619925488058	1.68604369159551e-32	Carbohydrate digestion and absorption: SLC2A2
P-hsa04630-1	Jak-STAT signaling pathway: MYC	5.89356676165565e-34	DOWN	-12.1481979215486	1.94487703134637e-32	Jak-STAT signaling pathway: MYC
P-hsa04066-46	HIF-1 signaling pathway: ENO1	1.0161943559464e-33	DOWN	-12.1035682451285	3.26960534025753e-32	HIF-1 signaling pathway: ENO1
P-hsa04066-89	HIF-1 signaling pathway: CDKN1A	1.16698333699094e-33	DOWN	-12.092207963858	3.66318915782277e-32	HIF-1 signaling pathway: CDKN1A
P-hsa04210-56	Apoptosis: BAX	1.28810265960378e-33	UP	12.0840934772361	3.94711457835729e-32	Apoptosis: BAX
P-hsa04921-28	Oxytocin signaling pathway: EEF2	2.02702623139327e-33	UP	12.0467668387757	6.06693665070497e-32	Oxytocin signaling pathway: EEF2
P-hsa04024-12	cAMP signaling pathway: SLC9A1	2.08775904507748e-33	DOWN	-12.0443324927891	6.10669520685163e-32	cAMP signaling pathway: SLC9A1
P-hsa04916-4	Melanogenesis: TYR	3.51368842443917e-33	DOWN	-12.0013257136934	1.0049148893896e-31	Melanogenesis: TYR
P-hsa04340-17	Hedgehog signaling pathway: SMO	8.38719871617735e-33	UP	11.9291067827591	2.34659233646092e-31	Hedgehog signaling pathway: SMO
P-hsa04072-36	Phospholipase D signaling pathway: MTOR	1.029071042659e-32	DOWN	-11.9120663608532	2.81790304660028e-31	Phospholipase D signaling pathway: MTOR
P-hsa04360-108	Axon guidance: CFL1	1.36429178520715e-32	UP	11.8885343496499	3.65800734908668e-31	Axon guidance: CFL1
P-hsa04261-34	Adrenergic signaling in cardiomyocytes: AKT3	1.60910441574368e-32	DOWN	-11.8747397223928	4.22636200624922e-31	Adrenergic signaling in cardiomyocytes: AKT3
P-hsa04911-56	Insulin secretion: CAMK2A*	2.41722232151958e-32	DOWN	-11.8406588785811	6.2219302555914e-31	Insulin secretion: CAMK2A*
P-hsa04210-64	Apoptosis: TNFRSF10D*	5.59514585330967e-32	UP	11.7700628449711	1.41195151239403e-30	Apoptosis: TNFRSF10D*
P-hsa04668-153	TNF signaling pathway: MAPK14*	7.39319259668835e-32	DOWN	-11.7465308337678	1.82981516768037e-30	TNF signaling pathway: MAPK14*
P-hsa04728-44	Dopaminergic synapse: FOS	1.12718041724498e-31	DOWN	-11.7108270926317	2.73713433395149e-30	Dopaminergic synapse: FOS
P-hsa04916-9	Melanogenesis: PRKACA	1.18242185019296e-31	DOWN	-11.7067698493208	2.81810540962655e-30	Melanogenesis: PRKACA
P-hsa04933-27	AGE-RAGE signaling pathway in diabetic complications: TNF	1.288714685969e-31	DOWN	-11.6994668113612	3.01559236516745e-30	AGE-RAGE signaling pathway in diabetic complications: TNF
P-hsa04510-47	Focal adhesion: CCND1	1.3262124792124e-31	DOWN	-11.6970324653746	3.0479204656185e-30	Focal adhesion: CCND1
P-hsa04014-41	Ras signaling pathway: RAC1*	1.85245710106235e-31	DOWN	-11.6686317621982	4.18265313871445e-30	Ras signaling pathway: RAC1*
P-hsa04210-70	Apoptosis: CFLAR*	2.48889094187896e-31	DOWN	-11.6434768536705	5.52276317620383e-30	Apoptosis: CFLAR*
P-hsa04932-97	Non-alcoholic fatty liver disease (NAFLD): TNF*	2.66029330065039e-31	DOWN	-11.6377967130352	5.80304657277467e-30	Non-alcoholic fatty liver disease (NAFLD): TNF*
P-hsa04210-71	Apoptosis: GADD45G	4.97684669192069e-31	DOWN	-11.5842411013311	1.06753361541699e-29	Apoptosis: GADD45G
P-hsa04919-31	Thyroid hormone signaling pathway: ATP2A2	6.36467090696881e-31	DOWN	-11.5631434361144	1.34284122250309e-29	Thyroid hormone signaling pathway: ATP2A2
P-hsa04728-60	Dopaminergic synapse: CACNA1A	1.35286452555322e-30	UP	11.4982275431397	2.8082849103016e-29	Dopaminergic synapse: CACNA1A
P-hsa04210-60	Apoptosis: BBC3	1.50017005680649e-30	UP	11.4893016078557	3.06463311604755e-29	Apoptosis: BBC3
P-hsa04115-38	p53 signaling pathway: GTSE1	1.67906713962265e-30	UP	11.4795642239095	3.37649907608493e-29	p53 signaling pathway: GTSE1
P-hsa04066-45	HIF-1 signaling pathway: ALDOA	1.96930118376105e-30	DOWN	-11.4657695966523	3.84013730833406e-29	HIF-1 signaling pathway: ALDOA
P-hsa04916-10	Melanogenesis: CAMK2A	1.96930118376105e-30	DOWN	-11.4657695966523	3.84013730833406e-29	Melanogenesis: CAMK2A
P-hsa04014-38	Ras signaling pathway: MAPK8	2.2453036191232e-30	DOWN	-11.4544093153818	4.31299366837546e-29	Ras signaling pathway: MAPK8
P-hsa04210-3	Apoptosis: BCL2L1	2.78442966272785e-30	DOWN	-11.4357459961516	5.26994261166286e-29	Apoptosis: BCL2L1
P-hsa04933-12	AGE-RAGE signaling pathway in diabetic complications: EGR1	3.38796738616424e-30	DOWN	-11.4187055742457	6.31929568984548e-29	AGE-RAGE signaling pathway in diabetic complications: EGR1
P-hsa04015-63	Rap1 signaling pathway: GNAI1	3.45181300480034e-30	DOWN	-11.4170826769213	6.3464047673972e-29	Rap1 signaling pathway: GNAI1
P-hsa04210-102	Apoptosis: PIDD1	8.12437016149618e-30	UP	11.3424294000005	1.47268512645712e-28	Apoptosis: PIDD1
P-hsa04064-130	NF-kappa B signaling pathway: TNF*	8.99655773182602e-30	DOWN	-11.3335034647164	1.6081346945639e-28	NF-kappa B signaling pathway: TNF*
P-hsa04919-39	Thyroid hormone signaling pathway: ESR1	9.25014611964679e-30	DOWN	-11.3310691187299	1.63081343232677e-28	Thyroid hormone signaling pathway: ESR1
P-hsa04621-33 35	NOD-like receptor signaling pathway: NLRC4 PYCARD	9.46684835698828e-30	DOWN	-11.3290404970744	1.64646403181675e-28	NOD-like receptor signaling pathway: NLRC4 PYCARD
P-hsa04922-36	Glucagon signaling pathway: GYS1	1.03374146291407e-29	UP	11.3213317347837	1.77390035036055e-28	Glucagon signaling pathway: GYS1
P-hsa04210-52	Apoptosis: PARP2	1.67140156957634e-29	UP	11.2791364043501	2.83038660532204e-28	Apoptosis: PARP2
P-hsa04024-25	cAMP signaling pathway: CFTR	1.97302929493797e-29	DOWN	-11.2645303284308	3.29777753582489e-28	cAMP signaling pathway: CFTR
P-hsa04921-67	Oxytocin signaling pathway: RYR1	2.79861320795767e-29	DOWN	-11.2336952792679	4.61771179313015e-28	Oxytocin signaling pathway: RYR1
P-hsa04062-35 36 37	Chemokine signaling pathway: PARD3 PRKCZ TIAM1	4.59163127420831e-29	DOWN	-11.18987705151	7.48029044291911e-28	Chemokine signaling pathway: PARD3 PRKCZ TIAM1
P-hsa04750-39	Inflammatory mediator regulation of TRP channels: C01245*	4.71941888920903e-29	DOWN	-11.1874427055234	7.59236513801503e-28	Inflammatory mediator regulation of TRP channels: C01245*
P-hsa04151-99	PI3K-Akt signaling pathway: MYB	5.87717675617669e-29	UP	11.167967937631	9.33818084592519e-28	PI3K-Akt signaling pathway: MYB
P-hsa04024-107 64	cAMP signaling pathway: NFKBIA NFKB1	6.49806766858177e-29	DOWN	-11.159042002347	1.01987964505668e-27	cAMP signaling pathway: NFKBIA NFKB1
P-hsa04210-73	Apoptosis: TRAF1	6.99009390914536e-29	DOWN	-11.1525504130495	1.08079503725722e-27	Apoptosis: TRAF1
P-hsa04924-34	Renin secretion: REN	7.05414010331054e-29	DOWN	-11.1517389643873	1.08079503725722e-27	Renin secretion: REN
P-hsa03320-62	PPAR signaling pathway: UBC	8.0143678989987e-29	DOWN	-11.1403786831168	1.21346958658957e-27	PPAR signaling pathway: UBC
P-hsa04630-28	Jak-STAT signaling pathway: CCND1	8.54202848313466e-29	DOWN	-11.1346985424815	1.27832449509236e-27	Jak-STAT signaling pathway: CCND1
P-hsa04726-72	Serotonergic synapse: KCNJ3	1.15324216427038e-28	DOWN	-11.1079207366294	1.70600306369652e-27	Serotonergic synapse: KCNJ3
P-hsa04110-59 15 16 17 18 19 20	Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2	1.75032292969213e-28	UP	11.070594098169	2.55984728467474e-27	Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
P-hsa04115-20	p53 signaling pathway: RRM2B	1.88178296590995e-28	UP	11.0641025088715	2.72118503047877e-27	p53 signaling pathway: RRM2B
P-hsa04066-42	HIF-1 signaling pathway: HK1	1.96887165129111e-28	DOWN	-11.0600452655606	2.81548646134629e-27	HIF-1 signaling pathway: HK1
P-hsa04530-7 52	Tight junction: PARD6A MPP5	2.35905445137116e-28	DOWN	-11.0438162923169	3.33637700979635e-27	Tight junction: PARD6A MPP5
P-hsa04668-111	TNF signaling pathway: BAG4	2.80044712385626e-28	DOWN	-11.0283987677355	3.9175820091337e-27	TNF signaling pathway: BAG4
P-hsa03320-45	PPAR signaling pathway: PDPK1	3.53992679957277e-28	DOWN	-11.0073011025187	4.89880192586038e-27	PPAR signaling pathway: PDPK1
P-hsa04930-13	Type II diabetes mellitus: C00162	4.47269617657024e-28	DOWN	-10.9862034373019	6.12378721196373e-27	Type II diabetes mellitus: C00162
P-hsa04713-56	Circadian entrainment: KCNJ3	4.84937012062448e-28	DOWN	-10.9789003993423	6.5011868179622e-27	Circadian entrainment: KCNJ3
P-hsa04728-71 72	Dopaminergic synapse: CLOCK ARNTL	4.84937012062448e-28	DOWN	-10.9789003993423	6.5011868179622e-27	Dopaminergic synapse: CLOCK ARNTL
P-hsa04360-18	Axon guidance: PTK2	5.21050964667082e-28	DOWN	-10.9724088100448	6.91332568584056e-27	Axon guidance: PTK2
P-hsa04014-103	Ras signaling pathway: KSR2	5.85508422708626e-28	DOWN	-10.9618599774364	7.68927897985716e-27	Ras signaling pathway: KSR2
P-hsa04668-20	TNF signaling pathway: IKBKG	5.96103472727053e-28	DOWN	-10.960237080112	7.74934514545169e-27	TNF signaling pathway: IKBKG
P-hsa04066-56	HIF-1 signaling pathway: TEK	6.88000637440389e-28	DOWN	-10.9472539015171	8.85456820385781e-27	HIF-1 signaling pathway: TEK
P-hsa04713-14	Circadian entrainment: PRKCA	7.25972739333759e-28	DOWN	-10.942385209544	9.15269986129465e-27	Circadian entrainment: PRKCA
P-hsa04066-37	HIF-1 signaling pathway: PDHA1	7.32500455099727e-28	DOWN	-10.9415737608818	9.15269986129465e-27	HIF-1 signaling pathway: PDHA1
P-hsa04912-17	GnRH signaling pathway: MAPK14	7.32500455099727e-28	DOWN	-10.9415737608818	9.15269986129465e-27	GnRH signaling pathway: MAPK14
P-hsa04261-52	Adrenergic signaling in cardiomyocytes: MAPK14	7.66022582271781e-28	DOWN	-10.9375165175709	9.4795294556133e-27	Adrenergic signaling in cardiomyocytes: MAPK14
P-hsa04724-67	Glutamatergic synapse: PLD1	9.92697726911695e-28	DOWN	-10.9139845063676	1.21676378527176e-26	Glutamatergic synapse: PLD1
P-hsa04010-131	MAPK signaling pathway: MYC	1.14505276636648e-27	DOWN	-10.9010013277726	1.39026689652232e-26	MAPK signaling pathway: MYC
P-hsa04152-78	AMPK signaling pathway: CCNA2	1.33238561115448e-27	UP	10.8872067005155	1.60259839397739e-26	AMPK signaling pathway: CCNA2
P-hsa04932-7	Non-alcoholic fatty liver disease (NAFLD): SREBF1	1.72462768812307e-27	DOWN	-10.8636746893122	2.05518132834666e-26	Non-alcoholic fatty liver disease (NAFLD): SREBF1
P-hsa04668-102	TNF signaling pathway: AKT3	1.7712289961235e-27	DOWN	-10.8612403433257	2.09135020001004e-26	TNF signaling pathway: AKT3
P-hsa04020-7	Calcium signaling pathway: ADCY1	1.83531192952073e-27	DOWN	-10.8579945486769	2.14731495753926e-26	Calcium signaling pathway: ADCY1
P-hsa04062-38	Chemokine signaling pathway: NCF1	1.97045545228352e-27	DOWN	-10.8515029593795	2.2642644349008e-26	Chemokine signaling pathway: NCF1
P-hsa04668-138	TNF signaling pathway: NFKB1*	1.97045545228352e-27	DOWN	-10.8515029593795	2.2642644349008e-26	TNF signaling pathway: NFKB1*
P-hsa04115-18	p53 signaling pathway: CCNG1	2.04168237618319e-27	UP	10.8482571647307	2.32534975057324e-26	p53 signaling pathway: CCNG1
P-hsa04064-115	NF-kappa B signaling pathway: XIAP	2.19188458898112e-27	DOWN	-10.8417655754333	2.4745223386129e-26	NF-kappa B signaling pathway: XIAP
P-hsa04921-65	Oxytocin signaling pathway: TRPM2	2.7114229907607e-27	DOWN	-10.8222908075409	3.03443599052959e-26	Oxytocin signaling pathway: TRPM2
P-hsa04210-59	Apoptosis: PMAIP1	3.41264254930979e-27	UP	10.8011931423241	3.78626806979456e-26	Apoptosis: PMAIP1
P-hsa04012-22	ErbB signaling pathway: EIF4EBP1	3.82794478675045e-27	UP	10.7906443097157	4.17505503436257e-26	ErbB signaling pathway: EIF4EBP1
P-hsa04923-43	Regulation of lipolysis in adipocytes: C00219	3.82794478675045e-27	DOWN	-10.7906443097157	4.17505503436257e-26	Regulation of lipolysis in adipocytes: C00219
P-hsa04010-14	MAPK signaling pathway: MAPT	5.54334947716996e-27	DOWN	-10.756563465904	5.99520233371238e-26	MAPK signaling pathway: MAPT
P-hsa04066-53	HIF-1 signaling pathway: EGF*	5.79272053667244e-27	DOWN	-10.7525062225931	6.21269277558119e-26	HIF-1 signaling pathway: EGF*
P-hsa04210-10	Apoptosis: BIRC2	6.05321088606004e-27	DOWN	-10.7484489792822	6.43841521517295e-26	Apoptosis: BIRC2
P-hsa04064-4	NF-kappa B signaling pathway: BIRC2	6.66788264595774e-27	DOWN	-10.7395230439981	7.03406964372756e-26	NF-kappa B signaling pathway: BIRC2
P-hsa04066-47	HIF-1 signaling pathway: PGK1	7.21651989825561e-27	DOWN	-10.7322200060385	7.5509439911016e-26	HIF-1 signaling pathway: PGK1
P-hsa03320-43	PPAR signaling pathway: ILK	7.94817763528647e-27	DOWN	-10.7232940707545	8.24943920694652e-26	PPAR signaling pathway: ILK
P-hsa04064-3	NF-kappa B signaling pathway: BCL2	8.08889666250745e-27	DOWN	-10.7216711734301	8.32832800371767e-26	NF-kappa B signaling pathway: BCL2
P-hsa04650-15	Natural killer cell mediated cytotoxicity: TNF	9.3891900288724e-27	DOWN	-10.707876546173	9.59038695806252e-26	Natural killer cell mediated cytotoxicity: TNF
P-hsa04064-2	NF-kappa B signaling pathway: BCL2L1	1.36777131499952e-26	DOWN	-10.6729842536991	1.38608006488534e-25	NF-kappa B signaling pathway: BCL2L1
P-hsa04911-24	Insulin secretion: INS	1.42882078763761e-26	DOWN	-10.6689270103882	1.43663465132001e-25	Insulin secretion: INS
P-hsa04064-51	NF-kappa B signaling pathway: TNFAIP3	1.74631299691805e-26	DOWN	-10.650263691158	1.74225180390197e-25	NF-kappa B signaling pathway: TNFAIP3
P-hsa04115-36	p53 signaling pathway: EI24	1.77702183661011e-26	UP	10.6486407938336	1.75925161824401e-25	p53 signaling pathway: EI24
P-hsa04151-105 62	PI3K-Akt signaling pathway: CCND1 CDK2	1.85615610485447e-26	UP	10.6445835505227	1.82356710454023e-25	PI3K-Akt signaling pathway: CCND1 CDK2
P-hsa04728-32	Dopaminergic synapse: CREB3	2.11513048417499e-26	DOWN	-10.6324118205899	2.06225222207062e-25	Dopaminergic synapse: CREB3
P-hsa04115-49	p53 signaling pathway: MDM2*	2.13361672558309e-26	UP	10.6316003719277	2.06463513219958e-25	p53 signaling pathway: MDM2*
P-hsa04910-43	Insulin signaling pathway: G6PC	2.22847808211834e-26	DOWN	-10.6275431286168	2.14033678484052e-25	Insulin signaling pathway: G6PC
P-hsa04066-5	HIF-1 signaling pathway: VEGFA	2.30736781736083e-26	DOWN	-10.6242973339681	2.19969065255065e-25	HIF-1 signaling pathway: VEGFA
P-hsa04933-57	AGE-RAGE signaling pathway in diabetic complications: FIGF	2.5169126411239e-26	DOWN	-10.6161828473463	2.38181365376945e-25	AGE-RAGE signaling pathway in diabetic complications: FIGF
P-hsa04066-44	HIF-1 signaling pathway: GAPDH	2.60591788790583e-26	DOWN	-10.6129370526975	2.44804111075533e-25	HIF-1 signaling pathway: GAPDH
P-hsa03460-16 49	Fanconi anemia pathway: FANCM C19orf40	2.79339458447363e-26	UP	10.6064454634001	2.56792773586968e-25	Fanconi anemia pathway: FANCM C19orf40
P-hsa03460-16 34	Fanconi anemia pathway: FANCM STRA13	2.79339458447363e-26	UP	10.6064454634001	2.56792773586968e-25	Fanconi anemia pathway: FANCM STRA13
P-hsa04066-58	HIF-1 signaling pathway: EDN1	2.79339458447363e-26	DOWN	-10.6064454634001	2.56792773586968e-25	HIF-1 signaling pathway: EDN1
P-hsa04933-52	AGE-RAGE signaling pathway in diabetic complications: FOXO1	2.81774998322286e-26	DOWN	-10.6056340147379	2.57194626128215e-25	AGE-RAGE signaling pathway in diabetic complications: FOXO1
P-hsa04064-50	NF-kappa B signaling pathway: NFKBIA*	3.62338111931555e-26	DOWN	-10.5821020035345	3.28400809898529e-25	NF-kappa B signaling pathway: NFKBIA*
P-hsa04670-35	Leukocyte transendothelial migration: PTK2	3.71876003391694e-26	DOWN	-10.579667657548	3.34688403052525e-25	Leukocyte transendothelial migration: PTK2
P-hsa04961-12	Endocrine and other factor-regulated calcium reabsorption: SLC8A1	4.02008520363491e-26	DOWN	-10.5723646195883	3.5929511507487e-25	Endocrine and other factor-regulated calcium reabsorption: SLC8A1
P-hsa04210-119	Apoptosis: BCL2*	4.38333944387514e-26	DOWN	-10.5642501329665	3.89059163052918e-25	Apoptosis: BCL2*
P-hsa04064-142	NF-kappa B signaling pathway: NFKB2*	4.94715201097323e-26	DOWN	-10.5528898516959	4.36094838227572e-25	NF-kappa B signaling pathway: NFKB2*
P-hsa04670-45	Leukocyte transendothelial migration: PXN	5.44008487694841e-26	DOWN	-10.5439639164119	4.76284982083851e-25	Leukocyte transendothelial migration: PXN
P-hsa04064-53	NF-kappa B signaling pathway: CXCL8	6.19157250930013e-26	DOWN	-10.5317921864792	5.38415798612789e-25	NF-kappa B signaling pathway: CXCL8
P-hsa04668-40	TNF signaling pathway: JUN	8.15588406759538e-26	DOWN	-10.5058258292893	7.04471328523171e-25	TNF signaling pathway: JUN
P-hsa04115-19	p53 signaling pathway: RFWD2	8.66184036765555e-26	UP	10.500145688654	7.43185903544846e-25	p53 signaling pathway: RFWD2
P-hsa04670-10	Leukocyte transendothelial migration: BCAR1	1.02852976741483e-25	DOWN	-10.4839167154103	8.76634311697272e-25	Leukocyte transendothelial migration: BCAR1
P-hsa04933-28	AGE-RAGE signaling pathway in diabetic complications: VCAM1	1.03739517385345e-25	DOWN	-10.4831052667482	8.78373413650916e-25	AGE-RAGE signaling pathway in diabetic complications: VCAM1
P-hsa04014-55	Ras signaling pathway: MLLT4	1.27442934882697e-25	DOWN	-10.4636304988558	1.07201998166034e-24	Ras signaling pathway: MLLT4
P-hsa04971-56	Gastric acid secretion: CAMK2A	1.30760245045995e-25	DOWN	-10.4611961528692	1.09278204788439e-24	Gastric acid secretion: CAMK2A
P-hsa04610-45	Complement and coagulation cascades: C4A	1.3531679588025e-25	DOWN	-10.4579503582205	1.12356591159924e-24	Complement and coagulation cascades: C4A
P-hsa04670-76	Leukocyte transendothelial migration: CDC42	1.47408257373312e-25	DOWN	-10.4498358715986	1.21611812332982e-24	Leukocyte transendothelial migration: CDC42
P-hsa04064-132	NF-kappa B signaling pathway: VCAM1	1.60569690730818e-25	DOWN	-10.4417213849768	1.31626236923926e-24	NF-kappa B signaling pathway: VCAM1
P-hsa04914-42	Progesterone-mediated oocyte maturation: ARAF	1.73407116622431e-25	DOWN	-10.4344183470172	1.41249974109537e-24	Progesterone-mediated oocyte maturation: ARAF
P-hsa04924-47	Renin secretion: KCNMA1	1.97100686132653e-25	DOWN	-10.4222466170844	1.59539989341336e-24	Renin secretion: KCNMA1
P-hsa04010-86	MAPK signaling pathway: MAP4K2	2.09229481265999e-25	DOWN	-10.4165664764491	1.68298963993338e-24	MAPK signaling pathway: MAP4K2
P-hsa04914-30	Progesterone-mediated oocyte maturation: CDK1*	2.18342958378998e-25	UP	10.4125092331382	1.74538749958864e-24	Progesterone-mediated oocyte maturation: CDK1*
P-hsa04727-8	GABAergic synapse: ADCY1	2.67866772736988e-25	UP	10.3930344652458	2.12805269452163e-24	GABAergic synapse: ADCY1
P-hsa04064-131	NF-kappa B signaling pathway: CCL4L1	3.14837858234656e-25	DOWN	-10.3776169406643	2.48586701563191e-24	NF-kappa B signaling pathway: CCL4L1
P-hsa04612-39	Antigen processing and presentation: PSME3	3.17524450405911e-25	DOWN	-10.3768054920021	2.49179248580736e-24	Antigen processing and presentation: PSME3
P-hsa04115-16	p53 signaling pathway: PPM1D	3.34127762661965e-25	UP	10.371936800029	2.60619654876333e-24	p53 signaling pathway: PPM1D
P-hsa04071-59 60	Sphingolipid signaling pathway: TP53 BCL2	4.30959496249247e-25	UP	10.3475933401635	3.3412341667035e-24	Sphingolipid signaling pathway: TP53 BCL2
P-hsa04261-15 17	Adrenergic signaling in cardiomyocytes: ACTC1 MYH6	4.42053480386578e-25	DOWN	-10.345158994177	3.40672352848818e-24	Adrenergic signaling in cardiomyocytes: ACTC1 MYH6
P-hsa04213-60	Longevity regulating pathway - multiple species: CAT	4.53430388397077e-25	UP	10.3427246481904	3.47360065397047e-24	Longevity regulating pathway - multiple species: CAT
P-hsa04912-43	GnRH signaling pathway: PTK2B	5.10478357992889e-25	DOWN	-10.3313643669199	3.88748903394584e-24	GnRH signaling pathway: PTK2B
P-hsa04064-52	NF-kappa B signaling pathway: TRAF1	5.94384117685669e-25	DOWN	-10.3167582910006	4.4998374085968e-24	NF-kappa B signaling pathway: TRAF1
P-hsa04915-30	Estrogen signaling pathway: CREB3*	8.19009024508466e-25	DOWN	-10.2859232418376	6.1641205528795e-24	Estrogen signaling pathway: CREB3*
P-hsa04742-47	Taste transduction: GABRA1	8.94548259699059e-25	UP	7.33062721416541	6.69350936181796e-24	Taste transduction: GABRA1
P-hsa04012-65	ErbB signaling pathway: MYC	9.61049971689645e-25	DOWN	-10.2705057172561	7.14954516511314e-24	ErbB signaling pathway: MYC
P-hsa04724-68	Glutamatergic synapse: MAPK1	1.11802943348118e-24	DOWN	-10.2558996413368	8.2695625338522e-24	Glutamatergic synapse: MAPK1
P-hsa04115-21	p53 signaling pathway: DDB2	1.20579211316753e-24	UP	10.2485966033771	8.86773971226637e-24	p53 signaling pathway: DDB2
P-hsa04910-42	Insulin signaling pathway: PCK1	1.47461311447068e-24	DOWN	-10.2291218354847	1.07831083995668e-23	Insulin signaling pathway: PCK1
P-hsa04668-128	TNF signaling pathway: CHUK*	1.91132916112051e-24	DOWN	-10.2039669269571	1.38976306800118e-23	TNF signaling pathway: CHUK*
P-hsa04261-37	Adrenergic signaling in cardiomyocytes: CREB3	2.11286472222436e-24	DOWN	-10.1942295430109	1.52767241432739e-23	Adrenergic signaling in cardiomyocytes: CREB3
P-hsa04115-58	p53 signaling pathway: CASP3	2.29678685743205e-24	DOWN	-10.186115056389	1.65137691928215e-23	p53 signaling pathway: CASP3
P-hsa04933-30	AGE-RAGE signaling pathway in diabetic complications: CXCL8	2.49655628482792e-24	DOWN	-10.1780005697672	1.78503774365197e-23	AGE-RAGE signaling pathway in diabetic complications: CXCL8
P-hsa04210-72	Apoptosis: BCL2A1	2.97380531652236e-24	DOWN	-10.1609601478613	2.11452344882004e-23	Apoptosis: BCL2A1
P-hsa04071-11	Sphingolipid signaling pathway: PRKCA	3.51196242873971e-24	DOWN	-10.1447311746177	2.4698883310317e-23	Sphingolipid signaling pathway: PRKCA
P-hsa04660-43	T cell receptor signaling pathway: RHOA	3.51196242873971e-24	DOWN	-10.1447311746177	2.4698883310317e-23	T cell receptor signaling pathway: RHOA
P-hsa04115-64	p53 signaling pathway: PMAIP1	3.57081508294783e-24	UP	10.1431082772933	2.49762989769231e-23	p53 signaling pathway: PMAIP1
P-hsa04550-34	Signaling pathways regulating pluripotency of stem cells: MAPK1*	3.66093050386792e-24	UP	10.1406739313067	2.54682030188001e-23	Signaling pathways regulating pluripotency of stem cells: MAPK1*
P-hsa04933-78	AGE-RAGE signaling pathway in diabetic complications: TGFB1	5.49571948759654e-24	DOWN	-10.1009129468598	3.80268332286922e-23	AGE-RAGE signaling pathway in diabetic complications: TGFB1
P-hsa04912-46	GnRH signaling pathway: JUN	5.82336151640118e-24	DOWN	-10.0952328062245	4.00784292599375e-23	GnRH signaling pathway: JUN
P-hsa04950-13	Maturity onset diabetes of the young: INS	5.871720316736e-24	DOWN	-10.0944213575623	4.01962981257406e-23	Maturity onset diabetes of the young: INS
P-hsa04666-40	Fc gamma R-mediated phagocytosis: PLA2G6	7.33891253379348e-24	DOWN	-10.0725122436833	4.99744996348794e-23	Fc gamma R-mediated phagocytosis: PLA2G6
P-hsa04062-25	Chemokine signaling pathway: ROCK1	7.58515950267538e-24	DOWN	-10.0692664490346	5.13794751575959e-23	Chemokine signaling pathway: ROCK1
P-hsa04115-39	p53 signaling pathway: BAX	7.64798911077011e-24	UP	10.0684550003724	5.15338323851368e-23	p53 signaling pathway: BAX
P-hsa04933-58	AGE-RAGE signaling pathway in diabetic complications: CCL2	7.71133412068099e-24	DOWN	-10.0676435517102	5.16900365276898e-23	AGE-RAGE signaling pathway in diabetic complications: CCL2
P-hsa04064-113	NF-kappa B signaling pathway: CFLAR	9.24416241453671e-24	DOWN	-10.0497916811422	6.16437151684391e-23	NF-kappa B signaling pathway: CFLAR
P-hsa04066-43	HIF-1 signaling pathway: PFKL	9.87337403090382e-24	DOWN	-10.0433000918447	6.55001668957382e-23	HIF-1 signaling pathway: PFKL
P-hsa04261-14 16	Adrenergic signaling in cardiomyocytes: TNNI3 TPM1	1.12617853298763e-23	DOWN	-10.0303169132498	7.43277831771838e-23	Adrenergic signaling in cardiomyocytes: TNNI3 TPM1
P-hsa04115-1	p53 signaling pathway: SIAH1	1.26341696717811e-23	UP	10.0189566319792	8.2960083508073e-23	p53 signaling pathway: SIAH1
P-hsa04912-26	GnRH signaling pathway: PLD1	1.27383062189349e-23	DOWN	-10.018145183317	8.32192898668487e-23	GnRH signaling pathway: PLD1
P-hsa04360-51	Axon guidance: FYN	1.28432927296169e-23	DOWN	-10.0173337346549	8.34814027425098e-23	Axon guidance: FYN
P-hsa04933-29	AGE-RAGE signaling pathway in diabetic complications: ICAM1	1.55090865564177e-23	DOWN	-9.99867041542464	1.00302484412611e-22	AGE-RAGE signaling pathway in diabetic complications: ICAM1
P-hsa03320-23	PPAR signaling pathway: ACADL	1.78250996344031e-23	DOWN	-9.98487578816752	1.14704516147384e-22	PPAR signaling pathway: ACADL
P-hsa04062-43	Chemokine signaling pathway: STAT1	1.79715298633352e-23	DOWN	-9.98406433950533	1.15071437483146e-22	Chemokine signaling pathway: STAT1
P-hsa04931-35	Insulin resistance: C00369	1.99870799726761e-23	DOWN	-9.97351550689695	1.27343425370466e-22	Insulin resistance: C00369
P-hsa04931-135	Insulin resistance: SREBF1**	2.0820545532569e-23	DOWN	-9.96945826358603	1.32000207391213e-22	Insulin resistance: SREBF1**
P-hsa04210-85	Apoptosis: FASLG*	2.29639093745096e-23	DOWN	-9.95972087963983	1.44168543243873e-22	Apoptosis: FASLG*
P-hsa04919-88	Thyroid hormone signaling pathway: FOXO1	2.29639093745096e-23	DOWN	-9.95972087963983	1.44168543243873e-22	Thyroid hormone signaling pathway: FOXO1
P-hsa04630-31	Jak-STAT signaling pathway: BCL2L1	2.39201832905057e-23	DOWN	-9.95566363632891	1.49443086868353e-22	Jak-STAT signaling pathway: BCL2L1
P-hsa04066-88	HIF-1 signaling pathway: BCL2	2.95656539912377e-23	DOWN	-9.93456597111214	1.83821240032478e-22	HIF-1 signaling pathway: BCL2
P-hsa03320-42	PPAR signaling pathway: ACOX1	3.20722896514634e-23	DOWN	-9.92645148449031	1.9844729221843e-22	PPAR signaling pathway: ACOX1
P-hsa04961-5	Endocrine and other factor-regulated calcium reabsorption: TRPV5	3.25983082311523e-23	DOWN	-9.92482858716594	2.00736950686569e-22	Endocrine and other factor-regulated calcium reabsorption: TRPV5
P-hsa04115-40	p53 signaling pathway: PIDD1	3.59386575073965e-23	UP	9.91509120321974	2.18174774584997e-22	p53 signaling pathway: PIDD1
P-hsa04115-31	p53 signaling pathway: ADGRB1	3.59386575073965e-23	UP	9.91509120321974	2.18174774584997e-22	p53 signaling pathway: ADGRB1
P-hsa04115-24	p53 signaling pathway: SERPINB5	3.59386575073965e-23	UP	9.91509120321974	2.18174774584997e-22	p53 signaling pathway: SERPINB5
P-hsa04919-30	Thyroid hormone signaling pathway: MYH6	3.89795079814864e-23	DOWN	-9.9069767165979	2.35524069352925e-22	Thyroid hormone signaling pathway: MYH6
P-hsa04064-135	NF-kappa B signaling pathway: CCL19	3.92972577651856e-23	DOWN	-9.90616526793572	2.36334442728009e-22	NF-kappa B signaling pathway: CCL19
P-hsa04917-47	Prolactin signaling pathway: INS	4.56550271428265e-23	DOWN	-9.89115346768533	2.73293115966594e-22	Prolactin signaling pathway: INS
P-hsa04931-46	Insulin resistance: PIK3R5*	4.65951345000882e-23	DOWN	-9.88912484602987	2.77629343063025e-22	Insulin resistance: PIK3R5*
P-hsa04360-117	Axon guidance: CFL1*	5.7979176621145e-23	UP	9.86721573215092	3.43867282541076e-22	Axon guidance: CFL1*
P-hsa04913-47	Ovarian steroidogenesis: INSR	6.18529247892289e-23	DOWN	-9.86072414285345	3.63491845679167e-22	Ovarian steroidogenesis: INSR
P-hsa04913-51	Ovarian steroidogenesis: INSR*	6.18529247892289e-23	DOWN	-9.86072414285345	3.63491845679167e-22	Ovarian steroidogenesis: INSR*
P-hsa04620-46	Toll-like receptor signaling pathway: TNF	6.81488534863185e-23	DOWN	-9.85098675890725	3.98670792894963e-22	Toll-like receptor signaling pathway: TNF
P-hsa04210-114	Apoptosis: HRK	6.87012922186539e-23	DOWN	-9.85017531024506	4.00083995861573e-22	Apoptosis: HRK
P-hsa04933-22	AGE-RAGE signaling pathway in diabetic complications: EDN1	8.20413895447936e-23	DOWN	-9.83232343967703	4.75618325874547e-22	AGE-RAGE signaling pathway in diabetic complications: EDN1
P-hsa04071-48	Sphingolipid signaling pathway: SMPD1	8.40488305337314e-23	DOWN	-9.82988909369048	4.85071053349383e-22	Sphingolipid signaling pathway: SMPD1
P-hsa04066-63	HIF-1 signaling pathway: TIMP1*	8.7503170845797e-23	DOWN	-9.82583185037956	5.00518137237959e-22	HIF-1 signaling pathway: TIMP1*
P-hsa04066-57	HIF-1 signaling pathway: TIMP1	8.7503170845797e-23	DOWN	-9.82583185037956	5.00518137237959e-22	HIF-1 signaling pathway: TIMP1
P-hsa04912-15	GnRH signaling pathway: CAMK2A	9.03675246890978e-23	DOWN	-9.82258605573083	5.14615063163136e-22	GnRH signaling pathway: CAMK2A
P-hsa04310-36	Wnt signaling pathway: MYC	1.37230880259652e-22	DOWN	-9.78039072529729	7.7804468235318e-22	Wnt signaling pathway: MYC
P-hsa04750-59	Inflammatory mediator regulation of TRP channels: TRPV2	1.6367570343314e-22	DOWN	-9.76253885472925	9.23906273326543e-22	Inflammatory mediator regulation of TRP channels: TRPV2
P-hsa04932-55	Non-alcoholic fatty liver disease (NAFLD): CASP3	1.66316335964068e-22	DOWN	-9.76091595740488	9.34712333562251e-22	Non-alcoholic fatty liver disease (NAFLD): CASP3
P-hsa04621-21 30	NOD-like receptor signaling pathway: NLRP3 PYCARD	1.99887885520134e-22	DOWN	-9.74225263817466	1.11850308114962e-21	NOD-like receptor signaling pathway: NLRP3 PYCARD
P-hsa04024-44 67	cAMP signaling pathway: CREB3 CREBBP	2.13071725962472e-22	DOWN	-9.73576104887719	1.18199703152458e-21	cAMP signaling pathway: CREB3 CREBBP
P-hsa04151-27	PI3K-Akt signaling pathway: FASLG	2.13071725962472e-22	DOWN	-9.73576104887719	1.18199703152458e-21	PI3K-Akt signaling pathway: FASLG
P-hsa04066-11	HIF-1 signaling pathway: SLC2A1	2.81625798128817e-22	DOWN	-9.70736034570077	1.55558970897763e-21	HIF-1 signaling pathway: SLC2A1
P-hsa04152-62	AMPK signaling pathway: EIF4EBP1	2.90733904035202e-22	UP	9.70411455105204	1.59814922105769e-21	AMPK signaling pathway: EIF4EBP1
P-hsa04660-40 41	T cell receptor signaling pathway: LAT GRAP2	2.93056112019903e-22	DOWN	-9.70330310238986	1.59814922105769e-21	T cell receptor signaling pathway: LAT GRAP2
P-hsa04660-41 46	T cell receptor signaling pathway: GRAP2 LCP2	2.93056112019903e-22	DOWN	-9.70330310238986	1.59814922105769e-21	T cell receptor signaling pathway: GRAP2 LCP2
P-hsa04022-71	cGMP-PKG signaling pathway: PPIF	2.97755739064958e-22	UP	9.70168020506549	1.61692673492237e-21	cGMP-PKG signaling pathway: PPIF
P-hsa04210-57	Apoptosis: BAK1	3.60316462018956e-22	UP	9.68220543717309	1.94843397738822e-21	Apoptosis: BAK1
P-hsa04919-46	Thyroid hormone signaling pathway: ATP1B4	3.86991166272762e-22	DOWN	-9.67490239921344	2.08392314223032e-21	Thyroid hormone signaling pathway: ATP1B4
P-hsa04150-31	mTOR signaling pathway: EIF4E	4.09081171557005e-22	UP	9.66922225857815	2.19369778247444e-21	mTOR signaling pathway: EIF4E
P-hsa04914-23	Progesterone-mediated oocyte maturation: PRKACA	4.2900546783511e-22	DOWN	-9.66435356660505	2.29099600458003e-21	Progesterone-mediated oocyte maturation: PRKACA
P-hsa04530-20 31	Tight junction: ACTB MLLT4	4.60705847170907e-22	DOWN	-9.6570505286454	2.44003467205332e-21	Tight junction: ACTB MLLT4
P-hsa04650-16	Natural killer cell mediated cytotoxicity: PRKCA	4.60705847170907e-22	DOWN	-9.6570505286454	2.44003467205332e-21	Natural killer cell mediated cytotoxicity: PRKCA
P-hsa04064-116	NF-kappa B signaling pathway: GADD45B	7.28449588402972e-22	DOWN	-9.60998650623876	3.8265902868352e-21	NF-kappa B signaling pathway: GADD45B
P-hsa04660-56	T cell receptor signaling pathway: CD3E	7.28449588402972e-22	DOWN	-9.60998650623876	3.8265902868352e-21	T cell receptor signaling pathway: CD3E
P-hsa04660-44	T cell receptor signaling pathway: PAK4	7.45873973371217e-22	DOWN	-9.60755216025221	3.90219432410063e-21	T cell receptor signaling pathway: PAK4
P-hsa04750-53	Inflammatory mediator regulation of TRP channels: TRPM8	7.75835611507465e-22	UP	9.60349491694129	4.04251187048627e-21	Inflammatory mediator regulation of TRP channels: TRPM8
P-hsa04723-42	Retrograde endocannabinoid signaling: KCNJ3	8.19792200803622e-22	DOWN	-9.59781477630601	4.2372392065633e-21	Retrograde endocannabinoid signaling: KCNJ3
P-hsa04723-50	Retrograde endocannabinoid signaling: KCNJ3*	8.19792200803622e-22	DOWN	-9.59781477630601	4.2372392065633e-21	Retrograde endocannabinoid signaling: KCNJ3*
P-hsa04630-24	Jak-STAT signaling pathway: MCL1	1.02970181358311e-21	DOWN	-9.57428276510269	5.30090493632587e-21	Jak-STAT signaling pathway: MCL1
P-hsa04115-50	p53 signaling pathway: RCHY1	1.14927273525215e-21	UP	9.56292248383212	5.89288450306578e-21	p53 signaling pathway: RCHY1
P-hsa04670-54	Leukocyte transendothelial migration: RAC1*	1.29265058219936e-21	DOWN	-9.55075075389937	6.60175118766102e-21	Leukocyte transendothelial migration: RAC1*
P-hsa04014-58 59	Ras signaling pathway: STK4 STK4	1.36548344853363e-21	DOWN	-9.54507061326408	6.94615493384496e-21	Ras signaling pathway: STK4 STK4
P-hsa03460-27	Fanconi anemia pathway: BRCA1	1.39792690652912e-21	UP	9.54263626727753	7.08319656969674e-21	Fanconi anemia pathway: BRCA1
P-hsa04151-102	PI3K-Akt signaling pathway: C8orf44-SGK3	1.47662408354413e-21	DOWN	-9.53695612664225	7.45260860988744e-21	PI3K-Akt signaling pathway: C8orf44-SGK3
P-hsa04150-56	mTOR signaling pathway: EIF4B	1.6603213194632e-21	DOWN	-9.52478439670949	8.34700600839507e-21	mTOR signaling pathway: EIF4B
P-hsa04380-72	Osteoclast differentiation: MAPK1	1.7536141672362e-21	DOWN	-9.51910425607421	8.78171763903889e-21	Osteoclast differentiation: MAPK1
P-hsa04261-3	Adrenergic signaling in cardiomyocytes: RYR2	1.91079778984444e-21	DOWN	-9.51017832079019	9.53177037027055e-21	Adrenergic signaling in cardiomyocytes: RYR2
P-hsa04930-26	Type II diabetes mellitus: INS*	2.08190627029185e-21	DOWN	-9.50125238550617	1.03452253662765e-20	Type II diabetes mellitus: INS*
P-hsa04630-30	Jak-STAT signaling pathway: CDKN1A	2.16461196676145e-21	DOWN	-9.49719514219526	1.07148292354692e-20	Jak-STAT signaling pathway: CDKN1A
P-hsa04530-11 24 23	Tight junction: TJP1 YBX3 CDK4	2.23310974533413e-21	DOWN	-9.49394934754652	1.10115411580269e-20	Tight junction: TJP1 YBX3 CDK4
P-hsa04151-34	PI3K-Akt signaling pathway: GYS1	2.4517316644454e-21	UP	9.48421196360032	1.20434299700047e-20	PI3K-Akt signaling pathway: GYS1
P-hsa04921-53	Oxytocin signaling pathway: RGS2	2.47087818911821e-21	DOWN	-9.48340051493814	1.20913316707039e-20	Oxytocin signaling pathway: RGS2
P-hsa04014-100	Ras signaling pathway: REL	2.5292096910329e-21	DOWN	-9.48096616895159	1.23298972437854e-20	Ras signaling pathway: REL
P-hsa04530-11 62	Tight junction: TJP1 SHROOM1	2.71250196114819e-21	DOWN	-9.47366313099194	1.31735472603688e-20	Tight junction: TJP1 SHROOM1
P-hsa04664-25	Fc epsilon RI signaling pathway: MAPK14	2.7549848826151e-21	DOWN	-9.47204023366757	1.33295697140061e-20	Fc epsilon RI signaling pathway: MAPK14
P-hsa04933-56	AGE-RAGE signaling pathway in diabetic complications: NFATC1	2.93159882104798e-21	DOWN	-9.4655486443701	1.41309651037032e-20	AGE-RAGE signaling pathway in diabetic complications: NFATC1
P-hsa04931-140	Insulin resistance: G00369	3.05063301355545e-21	UP	9.46108567672809	1.46498682404696e-20	Insulin resistance: G00369
P-hsa04024-9 95	cAMP signaling pathway: ATP1B4 FXYD1	3.26802423809626e-21	DOWN	-9.45418836309953	1.56354914291074e-20	cAMP signaling pathway: ATP1B4 FXYD1
P-hsa04010-57	MAPK signaling pathway: NLK	3.47712886289395e-21	DOWN	-9.44769677380206	1.65743142464611e-20	MAPK signaling pathway: NLK
P-hsa04114-80	Oocyte meiosis: CDC25C*	4.09110248899419e-21	UP	9.43065635189621	1.94289627429355e-20	Oocyte meiosis: CDC25C*
P-hsa04064-128	NF-kappa B signaling pathway: IL1B*	4.38599056632202e-21	DOWN	-9.42335331393656	2.07528303634428e-20	NF-kappa B signaling pathway: IL1B*
P-hsa04921-54	Oxytocin signaling pathway: RCAN1	4.84941037585695e-21	DOWN	-9.41280448132818	2.28615060576113e-20	Oxytocin signaling pathway: RCAN1
P-hsa04630-36	Jak-STAT signaling pathway: GFAP	5.07932137435685e-21	DOWN	-9.40793578935508	2.38579803240776e-20	Jak-STAT signaling pathway: GFAP
P-hsa04930-15	Type II diabetes mellitus: C00031*	5.44454668675697e-21	DOWN	-9.40063275139542	2.54804784940226e-20	Type II diabetes mellitus: C00031*
P-hsa04931-124	Insulin resistance: FOXO1*	5.65855023959071e-21	DOWN	-9.39657550808451	2.6386065791135e-20	Insulin resistance: FOXO1*
P-hsa04670-39	Leukocyte transendothelial migration: MAPK14	7.40817584959708e-21	DOWN	-9.36817480490808	3.44199361676225e-20	Leukocyte transendothelial migration: MAPK14
P-hsa04668-36	TNF signaling pathway: CREB3	8.31286382034644e-21	DOWN	-9.35600307497533	3.8484373153906e-20	TNF signaling pathway: CREB3
P-hsa04211-23	Longevity regulating pathway - mammal: SOD2	8.44146403511742e-21	DOWN	-9.35438017765097	3.89396566781223e-20	Longevity regulating pathway - mammal: SOD2
P-hsa04520-64	Adherens junction: CTNND1**	9.25543131014384e-21	DOWN	-9.34464279370476	4.25419289148397e-20	Adherens junction: CTNND1**
P-hsa04921-11	Oxytocin signaling pathway: PRKACA	9.54363684727546e-21	DOWN	-9.34139699905603	4.37105360229307e-20	Oxytocin signaling pathway: PRKACA
P-hsa04612-18	Antigen processing and presentation: KIR2DS2	9.84071427643511e-21	DOWN	-9.3381512044073	4.49113449424538e-20	Antigen processing and presentation: KIR2DS2
P-hsa04261-15 16	Adrenergic signaling in cardiomyocytes: ACTC1 TPM1	1.00695065740269e-20	DOWN	-9.33571685842075	4.5793127069868e-20	Adrenergic signaling in cardiomyocytes: ACTC1 TPM1
P-hsa04210-69	Apoptosis: PTPN13	1.04625724370339e-20	DOWN	-9.33165961510983	4.74131363607837e-20	Apoptosis: PTPN13
P-hsa04660-30	T cell receptor signaling pathway: CD40LG	1.08270405414942e-20	DOWN	-9.32800809613	4.88926357084319e-20	T cell receptor signaling pathway: CD40LG
P-hsa04921-76	Oxytocin signaling pathway: CDKN1A	1.20995460144765e-20	DOWN	-9.31624209052834	5.44479570651445e-20	Oxytocin signaling pathway: CDKN1A
P-hsa04064-133	NF-kappa B signaling pathway: CXCL2	1.26672936399185e-20	DOWN	-9.31137339855524	5.66069684533858e-20	NF-kappa B signaling pathway: CXCL2
P-hsa04919-25	Thyroid hormone signaling pathway: MTOR	1.26672936399185e-20	DOWN	-9.31137339855524	5.66069684533858e-20	Thyroid hormone signaling pathway: MTOR
P-hsa04350-11	TGF-beta signaling pathway: SMAD4*	1.50983477687547e-20	DOWN	-9.29271007932502	6.72372788179489e-20	TGF-beta signaling pathway: SMAD4*
P-hsa04213-61	Longevity regulating pathway - multiple species: ATG5	1.54476872895564e-20	UP	9.29027573333847	6.85557708333073e-20	Longevity regulating pathway - multiple species: ATG5
P-hsa04530-5 15	Tight junction: IGSF5 MPDZ	1.56850082562111e-20	DOWN	-9.28865283601411	6.93697787826242e-20	Tight junction: IGSF5 MPDZ
P-hsa04370-16	VEGF signaling pathway: HSPB1	1.89738436406171e-20	DOWN	-9.26836661945952	8.36278656351857e-20	VEGF signaling pathway: HSPB1
P-hsa04024-93	cAMP signaling pathway: ORAI1	1.95598807488714e-20	DOWN	-9.26512082481079	8.5916609296237e-20	cAMP signaling pathway: ORAI1
P-hsa04921-33	Oxytocin signaling pathway: C00942	1.98595749115927e-20	DOWN	-9.26349792748642	8.69363024191151e-20	Oxytocin signaling pathway: C00942
P-hsa04066-64	HIF-1 signaling pathway: LTBR	2.00111200262724e-20	DOWN	-9.26268647882424	8.73027507586865e-20	HIF-1 signaling pathway: LTBR
P-hsa04115-34	p53 signaling pathway: ZMAT3	2.11044295253169e-20	UP	9.25700633818895	9.17614891860906e-20	p53 signaling pathway: ZMAT3
P-hsa04931-137	Insulin resistance: MLXIP*	2.2088411767804e-20	DOWN	-9.25213764621585	9.57164509938173e-20	Insulin resistance: MLXIP*
P-hsa04668-48	TNF signaling pathway: CASP3	2.36500306157123e-20	DOWN	-9.2448346082562	1.02139561753093e-19	TNF signaling pathway: CASP3
P-hsa04062-8 41	Chemokine signaling pathway: PXN PTK2B	2.51294703386643e-20	DOWN	-9.23834301895873	1.08165981022946e-19	Chemokine signaling pathway: PXN PTK2B
P-hsa04010-87	MAPK signaling pathway: STK3	2.96863620380442e-20	DOWN	-9.2204911483907	1.2735449314321e-19	MAPK signaling pathway: STK3
P-hsa04725-50	Cholinergic synapse: BCL2	3.13008586652441e-20	DOWN	-9.21481100775541	1.33834568445745e-19	Cholinergic synapse: BCL2
P-hsa04150-33	mTOR signaling pathway: RPS6	4.13898287121343e-20	DOWN	-9.18478740725462	1.7638645547191e-19	mTOR signaling pathway: RPS6
P-hsa04213-13	Longevity regulating pathway - multiple species: RPS6KB1*	4.36320681211235e-20	DOWN	-9.17910726661934	1.85328289346158e-19	Longevity regulating pathway - multiple species: RPS6KB1*
P-hsa04360-29	Axon guidance: RASA1	4.74004692027443e-20	DOWN	-9.17018133133532	2.00672381131355e-19	Axon guidance: RASA1
P-hsa04924-58	Renin secretion: PPP3CA	4.8482897654831e-20	DOWN	-9.16774698534877	2.04581932071369e-19	Renin secretion: PPP3CA
P-hsa04530-11 36 14	Tight junction: TJP1 CTNNB1 CTNNA1	5.59285649156438e-20	DOWN	-9.15232946076728	2.33701503397512e-19	Tight junction: TJP1 CTNNB1 CTNNA1
P-hsa04530-11 13	Tight junction: TJP1 EPB41	5.59285649156438e-20	DOWN	-9.15232946076728	2.33701503397512e-19	Tight junction: TJP1 EPB41
P-hsa04530-11 43	Tight junction: TJP1 ACTN4	5.59285649156438e-20	DOWN	-9.15232946076728	2.33701503397512e-19	Tight junction: TJP1 ACTN4
P-hsa04115-55	p53 signaling pathway: SHISA5	6.40205040497032e-20	UP	9.13772338484798	2.66648507158472e-19	p53 signaling pathway: SHISA5
P-hsa04510-44	Focal adhesion: BCL2	6.45025231987057e-20	DOWN	-9.1369119361858	2.67789507602369e-19	Focal adhesion: BCL2
P-hsa04360-122	Axon guidance: CFL1**	8.25884579123286e-20	DOWN	-9.11013413033374	3.41772814576099e-19	Axon guidance: CFL1**
P-hsa04024-2	cAMP signaling pathway: CACNA1C	9.0339297267123e-20	DOWN	-9.10039674638754	3.72649601226882e-19	cAMP signaling pathway: CACNA1C
P-hsa04115-15	p53 signaling pathway: TSC2	9.51881809096574e-20	UP	9.09471660575226	3.9139676942725e-19	p53 signaling pathway: TSC2
P-hsa04520-7 68	Adherens junction: CDH1 CTNNB1	1.02564388326522e-19	DOWN	-9.08660211913042	4.19048786591219e-19	Adherens junction: CDH1 CTNNB1
P-hsa04670-55	Leukocyte transendothelial migration: RAC2	1.02564388326522e-19	DOWN	-9.08660211913042	4.19048786591219e-19	Leukocyte transendothelial migration: RAC2
P-hsa04621-21 31 41	NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1	1.13003517971349e-19	DOWN	-9.07605328652204	4.60239011484578e-19	NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1
P-hsa04550-66	Signaling pathways regulating pluripotency of stem cells: MYC	1.27302243925286e-19	DOWN	-9.0630701079271	5.16839078649348e-19	Signaling pathways regulating pluripotency of stem cells: MYC
P-hsa04917-68	Prolactin signaling pathway: CCND1	1.28253038153775e-19	DOWN	-9.06225865926492	5.19061824226127e-19	Prolactin signaling pathway: CCND1
P-hsa04062-53	Chemokine signaling pathway: NFKB1	1.30175729288298e-19	DOWN	-9.06063576194055	5.25191735404512e-19	Chemokine signaling pathway: NFKB1
P-hsa04723-73	Retrograde endocannabinoid signaling: MAPK14*	1.37132175490882e-19	DOWN	-9.05495562130527	5.49810311080263e-19	Retrograde endocannabinoid signaling: MAPK14*
P-hsa04723-68	Retrograde endocannabinoid signaling: MAPK14	1.37132175490882e-19	DOWN	-9.05495562130527	5.49810311080263e-19	Retrograde endocannabinoid signaling: MAPK14
P-hsa04932-28	Non-alcoholic fatty liver disease (NAFLD): GSK3A	1.73908165046394e-19	UP	9.0289892641154	6.95092572716489e-19	Non-alcoholic fatty liver disease (NAFLD): GSK3A
P-hsa04022-63	cGMP-PKG signaling pathway: C00575	1.77819061297975e-19	DOWN	-9.02655491812885	7.08523628143945e-19	cGMP-PKG signaling pathway: C00575
P-hsa04010-13	MAPK signaling pathway: STMN1	1.80474477668493e-19	DOWN	-9.02493202080448	7.16884730738734e-19	MAPK signaling pathway: STMN1
P-hsa04912-19	GnRH signaling pathway: MAPK7	1.91493663256737e-19	DOWN	-9.01844043150701	7.5831490649668e-19	GnRH signaling pathway: MAPK7
P-hsa04612-17 28	Antigen processing and presentation: CD4 HLA-DMA	2.01679080907894e-19	DOWN	-9.01276029087173	7.96199316344967e-19	Antigen processing and presentation: CD4 HLA-DMA
P-hsa04210-61	Apoptosis: APAF1	2.09280327490746e-19	UP	9.00870304756081	8.23681288931469e-19	Apoptosis: APAF1
P-hsa04666-20	Fc gamma R-mediated phagocytosis: PLA2G4B	2.37304091393579e-19	DOWN	-8.99490842030369	9.31129163486392e-19	Fc gamma R-mediated phagocytosis: PLA2G4B
P-hsa04152-49	AMPK signaling pathway: GYS1	2.75048109172928e-19	UP	8.97867944706002	1.07594807448498e-18	AMPK signaling pathway: GYS1
P-hsa04110-10 11 12 13 14 9 15 16 17 18 19 20	Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2	3.25827581962567e-19	UP	8.9600161278298	1.27072756965401e-18	Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
P-hsa04062-22 41	Chemokine signaling pathway: CRK PTK2B	3.69212469354383e-19	DOWN	-8.94622150057269	1.43557839292777e-18	Chemokine signaling pathway: CRK PTK2B
P-hsa04024-91	cAMP signaling pathway: GRIA1	3.83025797335245e-19	DOWN	-8.94216425726177	1.4848018107544e-18	cAMP signaling pathway: GRIA1
P-hsa04919-38	Thyroid hormone signaling pathway: TP53	5.40540598435058e-19	UP	8.90402617013915	2.08911636692469e-18	Thyroid hormone signaling pathway: TP53
P-hsa04919-18	Thyroid hormone signaling pathway: STAT1	6.48856406802013e-19	DOWN	-8.88373995358456	2.50023411842572e-18	Thyroid hormone signaling pathway: STAT1
P-hsa04064-129	NF-kappa B signaling pathway: PTGS2	6.92884205291089e-19	DOWN	-8.87643691562491	2.66191633495412e-18	NF-kappa B signaling pathway: PTGS2
P-hsa04213-52	Longevity regulating pathway - multiple species: SOD2	7.08205991092241e-19	UP	8.87400256963836	2.71268187659439e-18	Longevity regulating pathway - multiple species: SOD2
P-hsa04932-56	Non-alcoholic fatty liver disease (NAFLD): CASP7	8.01565203928862e-19	DOWN	-8.86020794238124	3.06117037820904e-18	Non-alcoholic fatty liver disease (NAFLD): CASP7
P-hsa04115-23	p53 signaling pathway: PTEN	8.62056176187431e-19	UP	8.8520934557594	3.28244467086752e-18	p53 signaling pathway: PTEN
P-hsa04380-69	Osteoclast differentiation: NFKB2	9.75405340653588e-19	DOWN	-8.83829882850228	3.70308753221583e-18	Osteoclast differentiation: NFKB2
P-hsa04064-114	NF-kappa B signaling pathway: BCL2A1*	1.24807096625252e-18	DOWN	-8.81070957398805	4.72431568696174e-18	NF-kappa B signaling pathway: BCL2A1*
P-hsa04024-108	cAMP signaling pathway: AMH	1.28473162043703e-18	UP	8.80746377933931	4.84882579326232e-18	cAMP signaling pathway: AMH
P-hsa04066-52	HIF-1 signaling pathway: FLT1	1.33205596772184e-18	DOWN	-8.8034065360284	5.01273693116375e-18	HIF-1 signaling pathway: FLT1
P-hsa04611-92	Platelet activation: RHOA*	1.59575723361524e-18	UP	8.78312031947381	5.98757889114522e-18	Platelet activation: RHOA*
P-hsa04210-84	Apoptosis: FAS**	1.69056440721173e-18	DOWN	-8.77662873017634	6.32487323279504e-18	Apoptosis: FAS**
P-hsa04360-82	Axon guidance: ILK	1.72753317844832e-18	UP	8.77419438418979	6.44444985699418e-18	Axon guidance: ILK
P-hsa04360-58	Axon guidance: PLXNC1	1.77806927086875e-18	DOWN	-8.77094858954106	6.61380101620833e-18	Axon guidance: PLXNC1
P-hsa04520-58	Adherens junction: CDH1*	1.83655780338659e-18	DOWN	-8.76729707056123	6.81167116126381e-18	Adherens junction: CDH1*
P-hsa04921-48	Oxytocin signaling pathway: PRKAG2	1.8971744992748e-18	DOWN	-8.7636455515814	7.01627465680078e-18	Oxytocin signaling pathway: PRKAG2
P-hsa04151-26	PI3K-Akt signaling pathway: RBL2	1.91088521210896e-18	DOWN	-8.76283410291922	7.04673142688892e-18	PI3K-Akt signaling pathway: RBL2
P-hsa04270-48	Vascular smooth muscle contraction: KCNMB2*	2.17509420685248e-18	DOWN	-8.74822802699992	7.9981321263404e-18	Vascular smooth muscle contraction: KCNMB2*
P-hsa04650-14	Natural killer cell mediated cytotoxicity: CSF2	2.44003149528663e-18	DOWN	-8.73524484840498	8.94678214938432e-18	Natural killer cell mediated cytotoxicity: CSF2
P-hsa04024-59	cAMP signaling pathway: AFDN	2.67855174166696e-18	DOWN	-8.7246960157966	9.76571130743735e-18	cAMP signaling pathway: AFDN
P-hsa04724-66	Glutamatergic synapse: PLA2G4B	2.67855174166696e-18	DOWN	-8.7246960157966	9.76571130743735e-18	Glutamatergic synapse: PLA2G4B
P-hsa04933-35	AGE-RAGE signaling pathway in diabetic complications: CCND1	2.69782516764077e-18	DOWN	-8.72388456713442	9.80819488913465e-18	AGE-RAGE signaling pathway in diabetic complications: CCND1
P-hsa04919-101	Thyroid hormone signaling pathway: NOTCH1	3.22675539128093e-18	DOWN	-8.70359835057983	1.16981244748692e-17	Thyroid hormone signaling pathway: NOTCH1
P-hsa04670-86	Leukocyte transendothelial migration: ACTB	3.39238423916465e-18	DOWN	-8.69791820994454	1.22640407747329e-17	Leukocyte transendothelial migration: ACTB
P-hsa04971-52 53	Gastric acid secretion: EZR ACTB	3.69606569386844e-18	DOWN	-8.68818082599834	1.33244721232736e-17	Gastric acid secretion: EZR ACTB
P-hsa04660-35	T cell receptor signaling pathway: NFATC1	3.77608696699975e-18	DOWN	-8.68574648001179	1.35749271690745e-17	T cell receptor signaling pathway: NFATC1
P-hsa04064-25	NF-kappa B signaling pathway: NFKB2	4.51296902975295e-18	DOWN	-8.66546026345721	1.61788054074987e-17	NF-kappa B signaling pathway: NFKB2
P-hsa04530-11 20 16	Tight junction: TJP1 ACTB CTTN	4.70995735325999e-18	DOWN	-8.66059157148411	1.68380975379045e-17	Tight junction: TJP1 ACTB CTTN
P-hsa04919-104	Thyroid hormone signaling pathway: MYC	5.09339519897855e-18	DOWN	-8.65166563620009	1.81584477038377e-17	Thyroid hormone signaling pathway: MYC
P-hsa04742-27	Taste transduction: CALHM1	5.12974428657244e-18	DOWN	-8.6508541875379	1.82375162895545e-17	Taste transduction: CALHM1
P-hsa04014-62	Ras signaling pathway: RASSF5	5.58642265468859e-18	DOWN	-8.6411168035917	1.98064075938959e-17	Ras signaling pathway: RASSF5
P-hsa04066-51	HIF-1 signaling pathway: TFRC	5.62624267751552e-18	DOWN	-8.64030535492952	1.9892786609787e-17	HIF-1 signaling pathway: TFRC
P-hsa04630-7	Jak-STAT signaling pathway: BCL2	7.00976041507029e-18	DOWN	-8.61515044640183	2.47166072717684e-17	Jak-STAT signaling pathway: BCL2
P-hsa04630-27	Jak-STAT signaling pathway: PIM1	7.47091357436424e-18	DOWN	-8.60784740844218	2.62706715032972e-17	Jak-STAT signaling pathway: PIM1
P-hsa04062-40	Chemokine signaling pathway: PRKACA	7.63118781094452e-18	DOWN	-8.60541306245563	2.67611409065003e-17	Chemokine signaling pathway: PRKACA
P-hsa04210-86	Apoptosis: BCL2L11	8.85217500005236e-18	DOWN	-8.58837264054978	3.09585576768136e-17	Apoptosis: BCL2L11
P-hsa04923-38	Regulation of lipolysis in adipocytes: PDE3B	9.4994932261821e-18	DOWN	-8.58025815392794	3.31323788132693e-17	Regulation of lipolysis in adipocytes: PDE3B
P-hsa04064-36	NF-kappa B signaling pathway: PLCG1	1.04112722886287e-17	DOWN	-8.56970932131956	3.6214344420176e-17	NF-kappa B signaling pathway: PLCG1
P-hsa04530-20 62	Tight junction: ACTB SHROOM1	1.18178203457546e-17	DOWN	-8.55510324540026	4.09960506333858e-17	Tight junction: ACTB SHROOM1
P-hsa04723-9	Retrograde endocannabinoid signaling: PRKCA	1.25898300666826e-17	DOWN	-8.5478002074406	4.33238269941725e-17	Retrograde endocannabinoid signaling: PRKCA
P-hsa04725-20	Cholinergic synapse: PRKCA	1.25898300666826e-17	DOWN	-8.5478002074406	4.33238269941725e-17	Cholinergic synapse: PRKCA
P-hsa04726-18	Serotonergic synapse: PRKCA	1.25898300666826e-17	DOWN	-8.5478002074406	4.33238269941725e-17	Serotonergic synapse: PRKCA
P-hsa04020-64	Calcium signaling pathway: C01330*	1.39885657668652e-17	DOWN	-8.53562847750785	4.78810748456264e-17	Calcium signaling pathway: C01330*
P-hsa04020-12	Calcium signaling pathway: C01330	1.39885657668652e-17	DOWN	-8.53562847750785	4.78810748456264e-17	Calcium signaling pathway: C01330
P-hsa04932-138	Non-alcoholic fatty liver disease (NAFLD): CEBPA	1.40870855406837e-17	DOWN	-8.53481702884567	4.80903954664719e-17	Non-alcoholic fatty liver disease (NAFLD): CEBPA
P-hsa04912-20	GnRH signaling pathway: PLA2G4B	1.43867715054786e-17	DOWN	-8.53238268285912	4.89835315543676e-17	GnRH signaling pathway: PLA2G4B
P-hsa04919-100	Thyroid hormone signaling pathway: CTNNB1*	1.46927469695572e-17	DOWN	-8.52994833687257	4.98933122686545e-17	Thyroid hormone signaling pathway: CTNNB1*
P-hsa04914-29	Progesterone-mediated oocyte maturation: CDK2	1.5759780340104e-17	UP	8.52183385025073	5.33758876255628e-17	Progesterone-mediated oocyte maturation: CDK2
P-hsa04923-52 53	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5*	1.58705991744292e-17	UP	8.52102240158855	5.3610134219135e-17	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5*
P-hsa04750-40	Inflammatory mediator regulation of TRP channels: C00219	1.93057766947912e-17	DOWN	-8.49830183904741	6.50432843094142e-17	Inflammatory mediator regulation of TRP channels: C00219
P-hsa04668-47	TNF signaling pathway: CASP7	2.15880306734547e-17	DOWN	-8.48531866045248	7.25425469366482e-17	TNF signaling pathway: CASP7
P-hsa04064-136	NF-kappa B signaling pathway: TNFSF13B*	2.18914064153735e-17	DOWN	-8.48369576312811	7.33704168140254e-17	NF-kappa B signaling pathway: TNFSF13B*
P-hsa04066-26	HIF-1 signaling pathway: C01245	2.26683712677679e-17	DOWN	-8.47963851981719	7.57771268093957e-17	HIF-1 signaling pathway: C01245
P-hsa04921-77	Oxytocin signaling pathway: KCNJ3	2.29867198193333e-17	DOWN	-8.47801562249283	7.66422497603161e-17	Oxytocin signaling pathway: KCNJ3
P-hsa04380-38	Osteoclast differentiation: FOS	2.31475441742336e-17	DOWN	-8.47720417383064	7.69790422538466e-17	Osteoclast differentiation: FOS
P-hsa04213-53	Longevity regulating pathway - multiple species: SOD1	2.34725305627819e-17	UP	8.47558127650628	7.74593508571804e-17	Longevity regulating pathway - multiple species: SOD1
P-hsa04723-10	Retrograde endocannabinoid signaling: CACNA1A	2.34725305627819e-17	UP	8.47558127650628	7.74593508571804e-17	Retrograde endocannabinoid signaling: CACNA1A
P-hsa04723-21	Retrograde endocannabinoid signaling: CACNA1A*	2.34725305627819e-17	UP	8.47558127650628	7.74593508571804e-17	Retrograde endocannabinoid signaling: CACNA1A*
P-hsa04726-10	Serotonergic synapse: PRKACA	2.71687186413879e-17	DOWN	-8.45854085460042	8.94274703106553e-17	Serotonergic synapse: PRKACA
P-hsa04022-19	cGMP-PKG signaling pathway: CNGB1	2.77416152131876e-17	DOWN	-8.45610650861387	9.10802519881949e-17	cGMP-PKG signaling pathway: CNGB1
P-hsa04151-37	PI3K-Akt signaling pathway: G6PC	3.01548164652229e-17	DOWN	-8.44636912466767	9.87512691876383e-17	PI3K-Akt signaling pathway: G6PC
P-hsa04210-105	Apoptosis: ACTB	3.10043505997334e-17	UP	8.44312333001894	1.01275632542784e-16	Apoptosis: ACTB
P-hsa04012-48	ErbB signaling pathway: CAMK2A	3.48861098765814e-17	DOWN	-8.42932870276182	1.13666894711798e-16	ErbB signaling pathway: CAMK2A
P-hsa04012-47	ErbB signaling pathway: PRKCA	3.51288172600797e-17	DOWN	-8.42851725409963	1.14168656095259e-16	ErbB signaling pathway: PRKCA
P-hsa04917-38	Prolactin signaling pathway: IRF1	3.71313924931887e-17	DOWN	-8.42202566480217	1.20373053246181e-16	Prolactin signaling pathway: IRF1
P-hsa04728-24	Dopaminergic synapse: SLC6A3	4.00699307573159e-17	DOWN	-8.41309972951815	1.29572866544386e-16	Dopaminergic synapse: SLC6A3
P-hsa04650-119	Natural killer cell mediated cytotoxicity: KLRC4-KLRK1	4.47579460333075e-17	DOWN	-8.40011655092321	1.44369615400669e-16	Natural killer cell mediated cytotoxicity: KLRC4-KLRK1
P-hsa04380-32	Osteoclast differentiation: AKT3	4.73008378428639e-17	DOWN	-8.39362496162575	1.52190445759415e-16	Osteoclast differentiation: AKT3
P-hsa04921-43	Oxytocin signaling pathway: CACNG3	5.10314060675582e-17	DOWN	-8.38469902634173	1.63784088800368e-16	Oxytocin signaling pathway: CACNG3
P-hsa04668-38	TNF signaling pathway: CEBPB	5.24587196963949e-17	DOWN	-8.38145323169299	1.67946199625025e-16	TNF signaling pathway: CEBPB
P-hsa04913-40	Ovarian steroidogenesis: HSD17B1	5.89770387015172e-17	DOWN	-8.36765860443588	1.88346026820974e-16	Ovarian steroidogenesis: HSD17B1
P-hsa04530-14 20 43	Tight junction: CTNNA1 ACTB ACTN4	6.1041868209881e-17	DOWN	-8.36360136112496	1.94457634619101e-16	Tight junction: CTNNA1 ACTB ACTN4
P-hsa04151-100	PI3K-Akt signaling pathway: PRKCA	6.31779626496144e-17	DOWN	-8.35954411781404	2.00765525753219e-16	PI3K-Akt signaling pathway: PRKCA
P-hsa04380-51	Osteoclast differentiation: FOS*	7.24846875579604e-17	DOWN	-8.34331514457037	2.29772888884471e-16	Osteoclast differentiation: FOS*
P-hsa04210-99	Apoptosis: BID**	7.39926590044231e-17	DOWN	-8.34088079858382	2.33976786581554e-16	Apoptosis: BID**
P-hsa04066-60	HIF-1 signaling pathway: NOS3	7.5531560622129e-17	DOWN	-8.33844645259727	2.38257643433039e-16	HIF-1 signaling pathway: NOS3
P-hsa04066-29	HIF-1 signaling pathway: LDHA	8.0892736957427e-17	DOWN	-8.33033196597544	2.5454511604941e-16	HIF-1 signaling pathway: LDHA
P-hsa04670-73	Leukocyte transendothelial migration: MYL12B*	8.14490616015928e-17	DOWN	-8.32952051731325	2.55670590929878e-16	Leukocyte transendothelial migration: MYL12B*
P-hsa04510-24 69	Focal adhesion: ZYX ACTB	9.21331313250221e-17	DOWN	-8.31491444139395	2.88504476922879e-16	Focal adhesion: ZYX ACTB
P-hsa04650-25	Natural killer cell mediated cytotoxicity: SH2D1B	9.73144846162969e-17	DOWN	-8.30842285209648	3.03989664323238e-16	Natural killer cell mediated cytotoxicity: SH2D1B
P-hsa04370-15	VEGF signaling pathway: PLA2G4B	1.01388075232585e-16	DOWN	-8.30355416012338	3.1518466865782e-16	VEGF signaling pathway: PLA2G4B
P-hsa04666-51	Fc gamma R-mediated phagocytosis: NCF1	1.01388075232585e-16	DOWN	-8.30355416012338	3.1518466865782e-16	Fc gamma R-mediated phagocytosis: NCF1
P-hsa04064-137	NF-kappa B signaling pathway: ICAM1	1.02083164140074e-16	DOWN	-8.3027427114612	3.16580800598254e-16	NF-kappa B signaling pathway: ICAM1
P-hsa04010-88 92	MAPK signaling pathway: ECSIT TRAF6	1.10799818687787e-16	DOWN	-8.293005327515	3.42786939065341e-16	MAPK signaling pathway: ECSIT TRAF6
P-hsa04621-30 32	NOD-like receptor signaling pathway: PYCARD CASP1	1.14644734298217e-16	DOWN	-8.28894808420408	3.53831590028309e-16	NOD-like receptor signaling pathway: PYCARD CASP1
P-hsa04810-8 79	Regulation of actin cytoskeleton: ARPC5 ACTB	1.24417504274415e-16	DOWN	-8.27921070025788	3.82160687353634e-16	Regulation of actin cytoskeleton: ARPC5 ACTB
P-hsa04810-8 82	Regulation of actin cytoskeleton: ARPC5 ACTB*	1.24417504274415e-16	DOWN	-8.27921070025788	3.82160687353634e-16	Regulation of actin cytoskeleton: ARPC5 ACTB*
P-hsa04014-65	Ras signaling pathway: MLLT4*	1.40635957638908e-16	DOWN	-8.26460462433858	4.30948755907796e-16	Ras signaling pathway: MLLT4*
P-hsa04930-9	Type II diabetes mellitus: C00238	1.41595704137196e-16	UP	8.26379317567639	4.32859076542924e-16	Type II diabetes mellitus: C00238
P-hsa04933-24	AGE-RAGE signaling pathway in diabetic complications: THBD	1.43534611013001e-16	DOWN	-8.26217027835203	4.37746550648655e-16	AGE-RAGE signaling pathway in diabetic complications: THBD
P-hsa04068-57	FoxO signaling pathway: IL7R	1.4749128853541e-16	DOWN	-8.25892448370329	4.48750090650291e-16	FoxO signaling pathway: IL7R
P-hsa04380-20	Osteoclast differentiation: MAP2K1	1.78364378284678e-16	DOWN	-8.23620392116215	5.41403195406558e-16	Osteoclast differentiation: MAP2K1
P-hsa04740-10	Olfactory transduction: ANO2	1.98781310246136e-16	DOWN	-8.22322074256722	6.01956579498298e-16	Olfactory transduction: ANO2
P-hsa04360-59	Axon guidance: MAPK1*	2.53520594267191e-16	UP	8.19400859072861	7.65917851694541e-16	Axon guidance: MAPK1*
P-hsa04918-14	Thyroid hormone synthesis: DUOX2	2.67570756937095e-16	DOWN	-8.18751700143115	8.06472047255365e-16	Thyroid hormone synthesis: DUOX2
P-hsa04064-134	NF-kappa B signaling pathway: CCL21	2.80492380352608e-16	DOWN	-8.18183686079586	8.43443209144407e-16	NF-kappa B signaling pathway: CCL21
P-hsa04976-16	Bile secretion: CFTR	3.27433531071345e-16	DOWN	-8.16317354156564	9.82300593214034e-16	Bile secretion: CFTR
P-hsa04530-8	Tight junction: LLGL2	3.47839588517123e-16	DOWN	-8.15587050360599	1.04109197772451e-15	Tight junction: LLGL2
P-hsa04664-47	Fc epsilon RI signaling pathway: MAPK8	4.11331617707041e-16	DOWN	-8.1355842870514	1.22826865890711e-15	Fc epsilon RI signaling pathway: MAPK8
P-hsa04670-2	Leukocyte transendothelial migration: MMP2	4.16878527864876e-16	DOWN	-8.13396138972704	1.24195061426411e-15	Leukocyte transendothelial migration: MMP2
P-hsa04666-38	Fc gamma R-mediated phagocytosis: CFL1	4.25337389275128e-16	UP	8.13152704374049	1.26422452655217e-15	Fc gamma R-mediated phagocytosis: CFL1
P-hsa04115-2	p53 signaling pathway: IGFBP3	4.63989747592211e-16	UP	8.1209782111321	1.37593273076308e-15	p53 signaling pathway: IGFBP3
P-hsa04010-68	MAPK signaling pathway: ATF2	4.92756395277664e-16	DOWN	-8.11367517317245	1.4578792660284e-15	MAPK signaling pathway: ATF2
P-hsa04917-48	Prolactin signaling pathway: CCND2	5.70682434153434e-16	DOWN	-8.09582330260442	1.68456030448502e-15	Prolactin signaling pathway: CCND2
P-hsa04014-68	Ras signaling pathway: RALGDS*	6.69572594371895e-16	DOWN	-8.07634853471201	1.97194491752089e-15	Ras signaling pathway: RALGDS*
P-hsa04917-40	Prolactin signaling pathway: TH	7.20365956324456e-16	DOWN	-8.06742259942799	2.11669174837802e-15	Prolactin signaling pathway: TH
P-hsa04622-9 35	RIG-I-like receptor signaling pathway: IRF3 PIN1	7.54646341929841e-16	DOWN	-8.06174245879271	2.21236866073737e-15	RIG-I-like receptor signaling pathway: IRF3 PIN1
P-hsa04066-49	HIF-1 signaling pathway: EPO	8.01091489937319e-16	DOWN	-8.05443942083306	2.34319260806666e-15	HIF-1 signaling pathway: EPO
P-hsa04919-89	Thyroid hormone signaling pathway: CASP9	1.09337341460504e-15	DOWN	-8.01630133371044	3.1908652711943e-15	Thyroid hormone signaling pathway: CASP9
P-hsa04750-7	Inflammatory mediator regulation of TRP channels: TRPV1	1.12262955412923e-15	DOWN	-8.0130555390617	3.26145425770727e-15	Inflammatory mediator regulation of TRP channels: TRPV1
P-hsa04750-58	Inflammatory mediator regulation of TRP channels: TRPV1**	1.12262955412923e-15	DOWN	-8.0130555390617	3.26145425770727e-15	Inflammatory mediator regulation of TRP channels: TRPV1**
P-hsa04722-46	Neurotrophin signaling pathway: ATF4*	1.35016213155254e-15	DOWN	-7.99033497652056	3.91364563808136e-15	Neurotrophin signaling pathway: ATF4*
P-hsa04211-43 59 60 61	Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101	1.56029052530107e-15	DOWN	-7.97248310595253	4.51257057542129e-15	Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101
P-hsa04910-32	Insulin signaling pathway: EIF4E	1.69926845301871e-15	DOWN	-7.96193427334414	4.90349439245534e-15	Insulin signaling pathway: EIF4E
P-hsa04913-64	Ovarian steroidogenesis: PLA2G4B	2.02802525267889e-15	DOWN	-7.94002515946519	5.83907941878687e-15	Ovarian steroidogenesis: PLA2G4B
P-hsa04340-46	Hedgehog signaling pathway: PRKACA	2.09543956637785e-15	DOWN	-7.93596791615427	6.01971143287566e-15	Hedgehog signaling pathway: PRKACA
P-hsa04623-9	Cytosolic DNA-sensing pathway: IKBKE	2.16505970177946e-15	DOWN	-7.93191067284336	6.20586155053488e-15	Cytosolic DNA-sensing pathway: IKBKE
P-hsa04062-60	Chemokine signaling pathway: GSK3A	2.19354121347083e-15	UP	7.93028777551899	6.27352787052658e-15	Chemokine signaling pathway: GSK3A
P-hsa04024-76	cAMP signaling pathway: C00416	2.20792001741508e-15	DOWN	-7.9294763268568	6.30064980579426e-15	cAMP signaling pathway: C00416
P-hsa04950-8	Maturity onset diabetes of the young: NEUROD1	2.34157730879749e-15	UP	7.92217328889715	6.66727875314685e-15	Maturity onset diabetes of the young: NEUROD1
P-hsa04380-48	Osteoclast differentiation: NFATC1	2.3723439783455e-15	DOWN	-7.92055039157279	6.73997064046502e-15	Osteoclast differentiation: NFATC1
P-hsa04933-65	AGE-RAGE signaling pathway in diabetic complications: COL1A1	2.81043896271247e-15	DOWN	-7.89945272635602	7.96703732381267e-15	AGE-RAGE signaling pathway in diabetic complications: COL1A1
P-hsa04360-96	Axon guidance: GSK3B	2.9414133194202e-15	DOWN	-7.89377258572073	8.31999767493143e-15	Axon guidance: GSK3B
P-hsa04520-10	Adherens junction: NLK	2.97992606808981e-15	DOWN	-7.89214968839637	8.4104492316482e-15	Adherens junction: NLK
P-hsa04650-110 111	Natural killer cell mediated cytotoxicity: ITGAL ITGB2	3.20079039017916e-15	DOWN	-7.88322375311235	9.01404208350236e-15	Natural killer cell mediated cytotoxicity: ITGAL ITGB2
P-hsa04340-15	Hedgehog signaling pathway: HHIP	3.28503745442785e-15	UP	7.87997795846361	9.23109869835948e-15	Hedgehog signaling pathway: HHIP
P-hsa04380-16	Osteoclast differentiation: NFKB1	3.48265775744573e-15	DOWN	-7.87267492050396	9.7650992022498e-15	Osteoclast differentiation: NFKB1
P-hsa04014-79	Ras signaling pathway: RAC1**	3.52813814636686e-15	DOWN	-7.8710520231796	9.87111694429164e-15	Ras signaling pathway: RAC1**
P-hsa04922-78	Glucagon signaling pathway: ACACA	3.71598067587906e-15	UP	7.86456043388213	1.03741152491461e-14	Glucagon signaling pathway: ACACA
P-hsa04151-25	PI3K-Akt signaling pathway: CDKN1B	3.76445921086897e-15	DOWN	-7.86293753655776	1.04867078017064e-14	PI3K-Akt signaling pathway: CDKN1B
P-hsa04912-14	GnRH signaling pathway: ATF4	3.88839644810333e-15	DOWN	-7.85888029324684	1.08085663687019e-14	GnRH signaling pathway: ATF4
P-hsa04742-8	Taste transduction: PLCB2	4.22974538207519e-15	DOWN	-7.84833146063846	1.17320739369198e-14	Taste transduction: PLCB2
P-hsa04724-13	Glutamatergic synapse: GRM5	4.75146790603507e-15	UP	7.83372538471916	1.3150836978639e-14	Glutamatergic synapse: GRM5
P-hsa04919-45	Thyroid hormone signaling pathway: SLC9A1	4.87583418123246e-15	DOWN	-7.83047959007042	1.3466091397524e-14	Thyroid hormone signaling pathway: SLC9A1
P-hsa04666-50 52	Fc gamma R-mediated phagocytosis: DNM2 AMPH	5.00332564694928e-15	DOWN	-7.82723379542169	1.37886083675026e-14	Fc gamma R-mediated phagocytosis: DNM2 AMPH
P-hsa04913-36	Ovarian steroidogenesis: CYP19A1	5.03570785583449e-15	DOWN	-7.82642234675951	1.38186695318955e-14	Ovarian steroidogenesis: CYP19A1
P-hsa04913-37	Ovarian steroidogenesis: CYP19A1*	5.03570785583449e-15	DOWN	-7.82642234675951	1.38186695318955e-14	Ovarian steroidogenesis: CYP19A1*
P-hsa04621-23	NOD-like receptor signaling pathway: CASP1	6.03108350617382e-15	DOWN	-7.80370178421837	1.65149031328632e-14	NOD-like receptor signaling pathway: CASP1
P-hsa04742-34	Taste transduction: GRM1	6.90242237538204e-15	DOWN	-7.78666136231252	1.88607592295471e-14	Taste transduction: GRM1
P-hsa04933-25	AGE-RAGE signaling pathway in diabetic complications: IL1A	7.08191209886139e-15	DOWN	-7.78341556766378	1.93102137102428e-14	AGE-RAGE signaling pathway in diabetic complications: IL1A
P-hsa04520-44 52 45	Adherens junction: ACTB ACTN4 CTNNA1	8.05059427201636e-15	DOWN	-7.76718659442011	2.19051053447887e-14	Adherens junction: ACTB ACTN4 CTNNA1
P-hsa04014-76	Ras signaling pathway: RALBP1*	8.58270920281745e-15	DOWN	-7.75907210779828	2.3303685113979e-14	Ras signaling pathway: RALBP1*
P-hsa04911-25	Insulin secretion: PRKCA	1.00050898985489e-14	DOWN	-7.73959733990587	2.71085277882787e-14	Insulin secretion: PRKCA
P-hsa04012-56	ErbB signaling pathway: JUN	1.11505282909255e-14	DOWN	-7.72580271264876	3.01485922487839e-14	ErbB signaling pathway: JUN
P-hsa04530-5 11 31	Tight junction: IGSF5 TJP1 MLLT4	1.2189938961368e-14	DOWN	-7.71444243137819	3.28898353108609e-14	Tight junction: IGSF5 TJP1 MLLT4
P-hsa04213-62	Longevity regulating pathway - multiple species: CAT*	1.25040377442048e-14	UP	7.71119663672945	3.36667292401498e-14	Longevity regulating pathway - multiple species: CAT*
P-hsa04211-62	Longevity regulating pathway - mammal: EHMT2	1.30729842794059e-14	DOWN	-7.70551649609417	3.51251164250424e-14	Longevity regulating pathway - mammal: EHMT2
P-hsa04915-28	Estrogen signaling pathway: KCNJ3	1.33245462318747e-14	DOWN	-7.70308215010762	3.5726439584214e-14	Estrogen signaling pathway: KCNJ3
P-hsa04622-11	RIG-I-like receptor signaling pathway: IRF7	1.41979755225395e-14	DOWN	-7.69496766348578	3.79891777494976e-14	RIG-I-like receptor signaling pathway: IRF7
P-hsa04071-66	Sphingolipid signaling pathway: C01245	1.45629090554198e-14	DOWN	-7.69172186883705	3.88847799882267e-14	Sphingolipid signaling pathway: C01245
P-hsa04960-27	Aldosterone-regulated sodium reabsorption: KCNJ1	1.51276776615369e-14	DOWN	-7.68685317686395	4.03091535204929e-14	Aldosterone-regulated sodium reabsorption: KCNJ1
P-hsa04014-67	Ras signaling pathway: RAPGEF5*	1.56147351825483e-14	DOWN	-7.68279593355303	4.15210003717761e-14	Ras signaling pathway: RAPGEF5*
P-hsa04071-69	Sphingolipid signaling pathway: RAC1	1.57139819812272e-14	DOWN	-7.68198448489085	4.1698752185236e-14	Sphingolipid signaling pathway: RAC1
P-hsa04310-32	Wnt signaling pathway: PPARD	1.64263003924359e-14	DOWN	-7.67630434425556	4.34992769651544e-14	Wnt signaling pathway: PPARD
P-hsa04072-3	Phospholipase D signaling pathway: MAPK1	1.77220387507901e-14	DOWN	-7.66656696030936	4.6738245639891e-14	Phospholipase D signaling pathway: MAPK1
P-hsa04623-25	Cytosolic DNA-sensing pathway: NFKB1*	1.77220387507901e-14	DOWN	-7.66656696030936	4.6738245639891e-14	Cytosolic DNA-sensing pathway: NFKB1*
P-hsa04666-29	Fc gamma R-mediated phagocytosis: WAS	1.84071028797162e-14	DOWN	-7.66169826833626	4.84456879472286e-14	Fc gamma R-mediated phagocytosis: WAS
P-hsa04664-30	Fc epsilon RI signaling pathway: PRKCA	1.88782173087429e-14	DOWN	-7.65845247368753	4.95842156660248e-14	Fc epsilon RI signaling pathway: PRKCA
P-hsa04151-32	PI3K-Akt signaling pathway: BCL2L1	1.94838184148433e-14	UP	7.65439523037661	5.10706197554039e-14	PI3K-Akt signaling pathway: BCL2L1
P-hsa04064-55	NF-kappa B signaling pathway: CXCL12	2.14176157752529e-14	DOWN	-7.64222350044386	5.60253485828263e-14	NF-kappa B signaling pathway: CXCL12
P-hsa04916-15	Melanogenesis: MITF*	2.6195888956499e-14	DOWN	-7.61625714325399	6.83856168093594e-14	Melanogenesis: MITF*
P-hsa04064-97	NF-kappa B signaling pathway: PLCG2	2.73732922649886e-14	DOWN	-7.6105770026187	7.13146298482597e-14	NF-kappa B signaling pathway: PLCG2
P-hsa04071-57	Sphingolipid signaling pathway: BAX	3.69730317177079e-14	DOWN	-7.5716274668339	9.61298824660405e-14	Sphingolipid signaling pathway: BAX
P-hsa04520-73	Adherens junction: PARD3	4.13692025827524e-14	DOWN	-7.5570213909146	1.07343072024198e-13	Adherens junction: PARD3
P-hsa04961-13	Endocrine and other factor-regulated calcium reabsorption: ATP2B1	4.21502640294571e-14	DOWN	-7.55458704492805	1.0914967767789e-13	Endocrine and other factor-regulated calcium reabsorption: ATP2B1
P-hsa04913-12	Ovarian steroidogenesis: HSD3B1	4.51402035600587e-14	DOWN	-7.54566110964403	1.1665751401967e-13	Ovarian steroidogenesis: HSD3B1
P-hsa04010-78	MAPK signaling pathway: MAP3K4	4.59912108589286e-14	DOWN	-7.54322676365748	1.1861861397884e-13	MAPK signaling pathway: MAP3K4
P-hsa04913-21	Ovarian steroidogenesis: CYP17A1	4.65672927748067e-14	DOWN	-7.54160386633311	1.19624961678994e-13	Ovarian steroidogenesis: CYP17A1
P-hsa04913-22	Ovarian steroidogenesis: CYP17A1*	4.65672927748067e-14	DOWN	-7.54160386633311	1.19624961678994e-13	Ovarian steroidogenesis: CYP17A1*
P-hsa04611-25	Platelet activation: ORAI1	5.78770465481124e-14	DOWN	-7.51320316315669	1.4838198985542e-13	Platelet activation: ORAI1
P-hsa04620-66	Toll-like receptor signaling pathway: CASP8	5.93302098931538e-14	DOWN	-7.50995736850795	1.5180512948805e-13	Toll-like receptor signaling pathway: CASP8
P-hsa04010-64	MAPK signaling pathway: DDIT3	6.08192284832435e-14	DOWN	-7.50671157385922	1.55306244162568e-13	MAPK signaling pathway: DDIT3
P-hsa04520-44 47	Adherens junction: ACTB TJP1	6.19600441854411e-14	DOWN	-7.50427722787267	1.57906092805273e-13	Adherens junction: ACTB TJP1
P-hsa04932-14	Non-alcoholic fatty liver disease (NAFLD): PKLR	6.43051486550137e-14	DOWN	-7.49940853589957	1.63558747666013e-13	Non-alcoholic fatty liver disease (NAFLD): PKLR
P-hsa04722-38	Neurotrophin signaling pathway: ATF4	7.69279393053931e-14	DOWN	-7.47587652469625	1.95278615159844e-13	Neurotrophin signaling pathway: ATF4
P-hsa04015-96	Rap1 signaling pathway: PLCE1	8.23279116110158e-14	UP	7.46695058941223	2.08574846935782e-13	Rap1 signaling pathway: PLCE1
P-hsa04971-55	Gastric acid secretion: MYLK4	8.75592648095913e-14	DOWN	-7.4588361027904	2.21392482927198e-13	Gastric acid secretion: MYLK4
P-hsa04961-26	Endocrine and other factor-regulated calcium reabsorption: TRPV5*	9.02961141607173e-14	DOWN	-7.45477885947948	2.27864899852634e-13	Endocrine and other factor-regulated calcium reabsorption: TRPV5*
P-hsa04020-22	Calcium signaling pathway: C00575	9.19784016468908e-14	UP	7.45234451349293	2.31655974402247e-13	Calcium signaling pathway: C00575
P-hsa04972-51	Pancreatic secretion: CLCA1	1.02109595635429e-13	DOWN	-7.43854988623581	2.566700187164e-13	Pancreatic secretion: CLCA1
P-hsa04370-14	VEGF signaling pathway: PTGS2	1.09913502429271e-13	DOWN	-7.42881250228961	2.75747909603259e-13	VEGF signaling pathway: PTGS2
P-hsa04976-59	Bile secretion: ABCB4	1.19760912147756e-13	DOWN	-7.41745222101904	2.99868276136503e-13	Bile secretion: ABCB4
P-hsa04370-25	VEGF signaling pathway: PXN	1.21981249063396e-13	DOWN	-7.41501787503249	3.04834694261341e-13	VEGF signaling pathway: PXN
P-hsa03460-48	Fanconi anemia pathway: RAD51	1.26543966823945e-13	UP	7.41014918305939	3.15624196322515e-13	Fanconi anemia pathway: RAD51
P-hsa04931-61	Insulin resistance: ACACB	1.54801972948742e-13	DOWN	-7.38337137720733	3.85358102872401e-13	Insulin resistance: ACACB
P-hsa04213-55	Longevity regulating pathway - multiple species: CRYAB	1.57659097714817e-13	UP	7.38093703122078	3.91712854747046e-13	Longevity regulating pathway - multiple species: CRYAB
P-hsa04610-17	Complement and coagulation cascades: PLG	1.65533837865406e-13	UP	7.37444544192332	4.1048564418647e-13	Complement and coagulation cascades: PLG
P-hsa04115-56	p53 signaling pathway: SESN3	1.76995836647189e-13	UP	7.3655195066393	4.38064695701792e-13	p53 signaling pathway: SESN3
P-hsa04621-34 35	NOD-like receptor signaling pathway: CASP1 PYCARD	1.85818117345132e-13	DOWN	-7.35902791734183	4.59017115207649e-13	NOD-like receptor signaling pathway: CASP1 PYCARD
P-hsa04921-58	Oxytocin signaling pathway: MEF2C	1.92716987920255e-13	DOWN	-7.35415922536873	4.75147056424077e-13	Oxytocin signaling pathway: MEF2C
P-hsa04921-60	Oxytocin signaling pathway: ELK1	2.06024533128648e-13	UP	7.34523329008471	5.06985801408356e-13	Oxytocin signaling pathway: ELK1
P-hsa04151-101	PI3K-Akt signaling pathway: PKN3	2.17580533881523e-13	DOWN	-7.33793025212506	5.34401044094504e-13	PI3K-Akt signaling pathway: PKN3
P-hsa04370-28	VEGF signaling pathway: SHC2	2.24273249041075e-13	DOWN	-7.33387300881414	5.49789850506408e-13	VEGF signaling pathway: SHC2
P-hsa04390-76	Hippo signaling pathway: MYC	2.90831394842325e-13	DOWN	-7.29898071634025	7.11596967988732e-13	Hippo signaling pathway: MYC
P-hsa04919-44	Thyroid hormone signaling pathway: PFKFB2	3.0519812017164e-13	DOWN	-7.29248912704279	7.45332031614611e-13	Thyroid hormone signaling pathway: PFKFB2
P-hsa04972-23	Pancreatic secretion: KCNMA1	4.12147638423771e-13	DOWN	-7.25191669393361	1.00460986865794e-12	Pancreatic secretion: KCNMA1
P-hsa04920-16	Adipocytokine signaling pathway: POMC	4.4285472964396e-13	DOWN	-7.24217930998741	1.07741783941735e-12	Adipocytokine signaling pathway: POMC
P-hsa04151-73	PI3K-Akt signaling pathway: MAPK1	4.45512779630204e-13	DOWN	-7.24136786132523	1.08183952336617e-12	PI3K-Akt signaling pathway: MAPK1
P-hsa04932-95	Non-alcoholic fatty liver disease (NAFLD): IL1A	4.70151072835854e-13	DOWN	-7.23406482336558	1.13951870195809e-12	Non-alcoholic fatty liver disease (NAFLD): IL1A
P-hsa04725-43	Cholinergic synapse: CREB3	4.8152630842727e-13	DOWN	-7.23081902871684	1.16489541155244e-12	Cholinergic synapse: CREB3
P-hsa04360-145	Axon guidance: ABLIM3	4.93171659981471e-13	DOWN	-7.22757323406811	1.19082913019916e-12	Axon guidance: ABLIM3
P-hsa04621-6	NOD-like receptor signaling pathway: NFKB1	5.329615242148e-13	DOWN	-7.21702440145972	1.28449715667499e-12	NOD-like receptor signaling pathway: NFKB1
P-hsa04151-98	PI3K-Akt signaling pathway: BCL2L1*	6.25938601823212e-13	UP	7.19511528758077	1.5057625804607e-12	PI3K-Akt signaling pathway: BCL2L1*
P-hsa04666-27	Fc gamma R-mediated phagocytosis: ARPC5	6.56424085678668e-13	DOWN	-7.1886236982833	1.57615260870979e-12	Fc gamma R-mediated phagocytosis: ARPC5
P-hsa04115-29	p53 signaling pathway: IGF1	7.65917207892359e-13	DOWN	-7.16752603306653	1.83563397869174e-12	p53 signaling pathway: IGF1
P-hsa04933-23	AGE-RAGE signaling pathway in diabetic complications: F3	7.88940320396258e-13	DOWN	-7.16346878975562	1.88729775529737e-12	AGE-RAGE signaling pathway in diabetic complications: F3
P-hsa04010-79	MAPK signaling pathway: HSPB1	9.30986487431254e-13	DOWN	-7.14074822721448	2.22296773529504e-12	MAPK signaling pathway: HSPB1
P-hsa04370-39	VEGF signaling pathway: RAC1	1.11760719576348e-12	DOWN	-7.11559331868679	2.66363048323629e-12	VEGF signaling pathway: RAC1
P-hsa04020-42	Calcium signaling pathway: MYLK4	1.19228276940839e-12	DOWN	-7.10666738340277	2.83635475827837e-12	Calcium signaling pathway: MYLK4
P-hsa04920-3	Adipocytokine signaling pathway: C15493	1.24964618801738e-12	DOWN	-7.10017579410531	2.967333291473e-12	Adipocytokine signaling pathway: C15493
P-hsa04151-33	PI3K-Akt signaling pathway: TP53	1.29443761013902e-12	UP	7.0953071021322	3.06803168369967e-12	PI3K-Akt signaling pathway: TP53
P-hsa04550-67	Signaling pathways regulating pluripotency of stem cells: MYC*	1.30971527942872e-12	DOWN	-7.09368420480784	3.09853596438376e-12	Signaling pathways regulating pluripotency of stem cells: MYC*
P-hsa04911-41	Insulin secretion: ABCC8	1.44692356810657e-12	UP	7.07988957755072	3.41686354523516e-12	Insulin secretion: ABCC8
P-hsa04662-29	B cell receptor signaling pathway: RAC1	1.51627943776552e-12	DOWN	-7.07339798825325	3.57408724616159e-12	B cell receptor signaling pathway: RAC1
P-hsa04022-50	cGMP-PKG signaling pathway: ATP2B1	1.57042677663331e-12	DOWN	-7.06852929628015	3.69495294611896e-12	cGMP-PKG signaling pathway: ATP2B1
P-hsa04015-18	Rap1 signaling pathway: CDH1	1.58889400708453e-12	DOWN	-7.06690639895578	3.73158136335364e-12	Rap1 signaling pathway: CDH1
P-hsa04530-20 22	Tight junction: ACTB MYL12B	1.59820734936192e-12	DOWN	-7.0660949502936	3.74158350890604e-12	Tight junction: ACTB MYL12B
P-hsa04727-17 37	GABAergic synapse: GABRA1 GPHN	1.59896731149831e-12	UP	6.52729303860378	3.74158350890604e-12	GABAergic synapse: GABRA1 GPHN
P-hsa04015-3	Rap1 signaling pathway: MAPK1	1.65522259003175e-12	UP	7.0612262583205	3.86619142172571e-12	Rap1 signaling pathway: MAPK1
P-hsa04360-40 142	Axon guidance: UNC5D PTPN11	1.70425568007086e-12	DOWN	-7.05716901500958	3.97350916712173e-12	Axon guidance: UNC5D PTPN11
P-hsa04022-48	cGMP-PKG signaling pathway: SLC8A2	1.76497881782854e-12	DOWN	-7.05230032303648	4.10023057499157e-12	cGMP-PKG signaling pathway: SLC8A2
P-hsa04213-2	Longevity regulating pathway - multiple species: RPS6KB1	1.76497881782854e-12	DOWN	-7.05230032303648	4.10023057499157e-12	Longevity regulating pathway - multiple species: RPS6KB1
P-hsa04662-32 51	B cell receptor signaling pathway: BLNK GRB2	1.79613129737273e-12	DOWN	-7.04986597704993	4.16508284634001e-12	B cell receptor signaling pathway: BLNK GRB2
P-hsa04014-35	Ras signaling pathway: NFKB1	1.82782299236709e-12	DOWN	-7.04743163106338	4.23094998413029e-12	Ras signaling pathway: NFKB1
P-hsa04530-1 5	Tight junction: IGSF5 IGSF5	1.97161073461146e-12	DOWN	-7.03688279845499	4.55558889666957e-12	Tight junction: IGSF5 IGSF5
P-hsa04360-123	Axon guidance: ENAH	2.34710887092557e-12	DOWN	-7.01253933858949	5.41349304100575e-12	Axon guidance: ENAH
P-hsa04742-55	Taste transduction: P2RX3	2.80868501037884e-12	DOWN	-6.9873844300618	6.46650734947687e-12	Taste transduction: P2RX3
P-hsa04151-96	PI3K-Akt signaling pathway: BCL2	2.95862278627185e-12	UP	6.98008139210215	6.79954915344976e-12	PI3K-Akt signaling pathway: BCL2
P-hsa04666-23	Fc gamma R-mediated phagocytosis: RPS6KB1	3.33965718024714e-12	DOWN	-6.9630409701963	7.66156647233167e-12	Fc gamma R-mediated phagocytosis: RPS6KB1
P-hsa04015-82	Rap1 signaling pathway: ITGA2B	3.41750565769465e-12	DOWN	-6.95979517554757	7.82620957553918e-12	Rap1 signaling pathway: ITGA2B
P-hsa04020-18	Calcium signaling pathway: C00002	4.47670770870294e-12	DOWN	-6.92165708842494	1.01793813958526e-11	Calcium signaling pathway: C00002
P-hsa04020-17	Calcium signaling pathway: C00004	4.47670770870294e-12	DOWN	-6.92165708842494	1.01793813958526e-11	Calcium signaling pathway: C00004
P-hsa04020-15	Calcium signaling pathway: C13051	4.47670770870294e-12	DOWN	-6.92165708842494	1.01793813958526e-11	Calcium signaling pathway: C13051
P-hsa04722-53	Neurotrophin signaling pathway: JUN	4.47671318574403e-12	DOWN	-6.92165708842494	1.01793813958526e-11	Neurotrophin signaling pathway: JUN
P-hsa04024-101	cAMP signaling pathway: HCN4	4.87808084505527e-12	DOWN	-6.90948535849219	1.10724692197286e-11	cAMP signaling pathway: HCN4
P-hsa04360-125	Axon guidance: ENAH*	5.01955099066798e-12	UP	6.90542811518127	1.13735248679396e-11	Axon guidance: ENAH*
P-hsa04622-6	RIG-I-like receptor signaling pathway: NFKB1	5.49982073590893e-12	DOWN	-6.89244493658634	1.24398405748942e-11	RIG-I-like receptor signaling pathway: NFKB1
P-hsa04024-123	cAMP signaling pathway: PAK1	5.78947293763349e-12	DOWN	-6.88514189862669	1.3049127269237e-11	cAMP signaling pathway: PAK1
P-hsa04911-54	Insulin secretion: RAB3A	5.78947293763349e-12	DOWN	-6.88514189862669	1.3049127269237e-11	Insulin secretion: RAB3A
P-hsa04623-8	Cytosolic DNA-sensing pathway: TBK1	6.09406097456472e-12	DOWN	-6.87783886066704	1.37116371927706e-11	Cytosolic DNA-sensing pathway: TBK1
P-hsa04662-27	B cell receptor signaling pathway: NFATC1	7.18627610165942e-12	DOWN	-6.85430684946372	1.6140902867078e-11	B cell receptor signaling pathway: NFATC1
P-hsa04660-14	T cell receptor signaling pathway: NFKB1	8.0035823846768e-12	DOWN	-6.83888932488223	1.79453145105907e-11	T cell receptor signaling pathway: NFKB1
P-hsa04151-97	PI3K-Akt signaling pathway: MCL1	8.18691057002145e-12	UP	6.8356435302335	1.83244415715089e-11	PI3K-Akt signaling pathway: MCL1
P-hsa04724-3	Glutamatergic synapse: GRIK1	8.37435148357664e-12	DOWN	-6.83239773558476	1.87114415961166e-11	Glutamatergic synapse: GRIK1
P-hsa04810-48	Regulation of actin cytoskeleton: IQGAP2	8.91176394325467e-12	DOWN	-6.82347180030074	1.98433221366241e-11	Regulation of actin cytoskeleton: IQGAP2
P-hsa04913-19	Ovarian steroidogenesis: STAR	8.91176394325467e-12	DOWN	-6.82347180030074	1.98433221366241e-11	Ovarian steroidogenesis: STAR
P-hsa04730-8	Long-term depression: GNA13*	9.7542522353988e-12	DOWN	-6.81048862170581	2.16817316527776e-11	Long-term depression: GNA13*
P-hsa04919-26	Thyroid hormone signaling pathway: THRB	1.0495804603715e-11	DOWN	-6.79993978909742	2.3289828491347e-11	Thyroid hormone signaling pathway: THRB
P-hsa04919-40	Thyroid hormone signaling pathway: RCAN2	1.10412544194634e-11	DOWN	-6.79263675113777	2.44579938689319e-11	Thyroid hormone signaling pathway: RCAN2
P-hsa04530-5 10	Tight junction: IGSF5 MAGI1	1.1484600904855e-11	DOWN	-6.78695661050249	2.5396359732901e-11	Tight junction: IGSF5 MAGI1
P-hsa04915-66	Estrogen signaling pathway: AKT3*	1.16144428460159e-11	DOWN	-6.78533371317812	2.56394304336578e-11	Estrogen signaling pathway: AKT3*
P-hsa04530-20 37	Tight junction: ACTB TJP3	1.18784551595823e-11	DOWN	-6.78208791852939	2.61773489561343e-11	Tight junction: ACTB TJP3
P-hsa04360-33 134	Axon guidance: NCK1 PAK4	1.24242352099597e-11	DOWN	-6.77559632923192	2.73333174619113e-11	Axon guidance: NCK1 PAK4
P-hsa04010-12	MAPK signaling pathway: PLA2G4B	1.57181406070257e-11	DOWN	-6.74151548542021	3.45208992512663e-11	MAPK signaling pathway: PLA2G4B
P-hsa04068-51	FoxO signaling pathway: BCL6	1.66205462753858e-11	DOWN	-6.73340099879838	3.63786446537781e-11	FoxO signaling pathway: BCL6
P-hsa04068-56	FoxO signaling pathway: BCL6*	1.66205462753858e-11	DOWN	-6.73340099879838	3.63786446537781e-11	FoxO signaling pathway: BCL6*
P-hsa04151-36	PI3K-Akt signaling pathway: PCK1	1.7282218805397e-11	DOWN	-6.7277208581631	3.76986705127897e-11	PI3K-Akt signaling pathway: PCK1
P-hsa04933-63	AGE-RAGE signaling pathway in diabetic complications: SELE	1.7282218805397e-11	DOWN	-6.7277208581631	3.76986705127897e-11	AGE-RAGE signaling pathway in diabetic complications: SELE
P-hsa04918-10	Thyroid hormone synthesis: TG	1.87881354202831e-11	DOWN	-6.71554912823034	4.09142644431546e-11	Thyroid hormone synthesis: TG
P-hsa04910-46	Insulin signaling pathway: FBP1	2.06504492566128e-11	DOWN	-6.70175450097322	4.4818091388298e-11	Insulin signaling pathway: FBP1
P-hsa04962-10	Vasopressin-regulated water reabsorption: AQP2	2.06504492566128e-11	DOWN	-6.70175450097322	4.4818091388298e-11	Vasopressin-regulated water reabsorption: AQP2
P-hsa04972-18	Pancreatic secretion: PRKCA	2.1349952992708e-11	DOWN	-6.69688580900012	4.62582314842008e-11	Pancreatic secretion: PRKCA
P-hsa04024-21	cAMP signaling pathway: AKT3	2.97519987227271e-11	DOWN	-6.64819888926912	6.43543232876467e-11	cAMP signaling pathway: AKT3
P-hsa04510-20 69	Focal adhesion: VASP ACTB	3.1436770773344e-11	DOWN	-6.64008440264728	6.78844362169358e-11	Focal adhesion: VASP ACTB
P-hsa04921-23	Oxytocin signaling pathway: C00219	3.91601950634721e-11	DOWN	-6.60762645615994	8.4420722021254e-11	Oxytocin signaling pathway: C00219
P-hsa04024-3	cAMP signaling pathway: RYR2	4.20489903268151e-11	DOWN	-6.59707762355156	9.04967400511891e-11	cAMP signaling pathway: RYR2
P-hsa04921-55	Oxytocin signaling pathway: PTGS2*	4.29790725110956e-11	DOWN	-6.59383182890282	9.23440172316862e-11	Oxytocin signaling pathway: PTGS2*
P-hsa04380-68	Osteoclast differentiation: TGFBR1	4.79399018549953e-11	DOWN	-6.57760285565915	1.02831089478965e-10	Osteoclast differentiation: TGFBR1
P-hsa04920-5	Adipocytokine signaling pathway: NFKBIA	4.92651327984482e-11	DOWN	-6.57354561234824	1.05497880052584e-10	Adipocytokine signaling pathway: NFKBIA
P-hsa04666-30 44	Fc gamma R-mediated phagocytosis: C04637 GSN	5.20239931235214e-11	DOWN	-6.5654311257264	1.11220729485003e-10	Fc gamma R-mediated phagocytosis: C04637 GSN
P-hsa04370-23	VEGF signaling pathway: PTK2	5.23080518525138e-11	DOWN	-6.56461967706422	1.11642558431485e-10	VEGF signaling pathway: PTK2
P-hsa04950-16	Maturity onset diabetes of the young: PAX4	5.52333977160982e-11	DOWN	-6.55650519044239	1.17691031226189e-10	Maturity onset diabetes of the young: PAX4
P-hsa04024-62	cAMP signaling pathway: BAD	5.64478237469473e-11	UP	6.55325939579365	1.20079915970779e-10	cAMP signaling pathway: BAD
P-hsa04742-67	Taste transduction: PRKACA	6.22438204850221e-11	DOWN	-6.53865331987435	1.32191084099379e-10	Taste transduction: PRKACA
P-hsa04360-131	Axon guidance: RAC1****	6.25823490870409e-11	DOWN	-6.53784187121216	1.32691076235621e-10	Axon guidance: RAC1****
P-hsa04724-44	Glutamatergic synapse: PRKACA*	6.29226782850681e-11	DOWN	-6.53703042254998	1.33193235119873e-10	Glutamatergic synapse: PRKACA*
P-hsa04072-57	Phospholipase D signaling pathway: C06124	6.89930140743794e-11	DOWN	-6.52323579529286	1.45802970630092e-10	Phospholipase D signaling pathway: C06124
P-hsa04740-16	Olfactory transduction: PRKG1	7.01221418734397e-11	DOWN	-6.52080144930631	1.47946223919864e-10	Olfactory transduction: PRKG1
P-hsa04662-24	B cell receptor signaling pathway: FOS	7.08849128113601e-11	DOWN	-6.51917855198195	1.49310773794142e-10	B cell receptor signaling pathway: FOS
P-hsa04931-104	Insulin resistance: C00369*	7.44189969263021e-11	UP	6.51187551402229	1.56498772947959e-10	Insulin resistance: C00369*
P-hsa04340-49	Hedgehog signaling pathway: CCND1	7.85479745537378e-11	DOWN	-6.50376102740046	1.64912305466004e-10	Hedgehog signaling pathway: CCND1
P-hsa04971-39	Gastric acid secretion: EZR	8.47070583985106e-11	DOWN	-6.49240074612989	1.77553720128474e-10	Gastric acid secretion: EZR
P-hsa04723-46	Retrograde endocannabinoid signaling: ADCY1	9.43321129129698e-11	UP	6.47617177288622	1.97407202144703e-10	Retrograde endocannabinoid signaling: ADCY1
P-hsa04914-15	Progesterone-mediated oocyte maturation: ANAPC10	9.48404531925654e-11	DOWN	-6.47536032422404	1.9814880399161e-10	Progesterone-mediated oocyte maturation: ANAPC10
P-hsa04115-17	p53 signaling pathway: TP73	9.63815965503616e-11	UP	6.47292597823749	2.01042325381386e-10	p53 signaling pathway: TP73
P-hsa04923-66	Regulation of lipolysis in adipocytes: LIPE	9.74225994390925e-11	DOWN	-6.47130308091312	2.0288492795811e-10	Regulation of lipolysis in adipocytes: LIPE
P-hsa04920-37	Adipocytokine signaling pathway: IRS1	9.90047449835051e-11	UP	6.46886873492657	2.05846699182183e-10	Adipocytokine signaling pathway: IRS1
P-hsa04370-36	VEGF signaling pathway: NOS3	1.26653463366436e-10	DOWN	-6.43154209646613	2.62908076375166e-10	VEGF signaling pathway: NOS3
P-hsa04010-62	MAPK signaling pathway: MEF2C	1.3430957214446e-10	DOWN	-6.42261616118211	2.78351721980548e-10	MAPK signaling pathway: MEF2C
P-hsa04530-30	Tight junction: AKT3	1.38674392294411e-10	UP	6.41774746920901	2.86935599490205e-10	Tight junction: AKT3
P-hsa04933-62	AGE-RAGE signaling pathway in diabetic complications: AGER**	1.39415216059237e-10	DOWN	-6.41693602054683	2.88005430286096e-10	AGE-RAGE signaling pathway in diabetic complications: AGER**
P-hsa04620-40	Toll-like receptor signaling pathway: CCL5	1.439420646077e-10	DOWN	-6.41206732857373	2.96880508253381e-10	Toll-like receptor signaling pathway: CCL5
P-hsa04010-15	MAPK signaling pathway: NFKB1	1.49405116675725e-10	DOWN	-6.40638718793844	3.07655016258653e-10	MAPK signaling pathway: NFKB1
P-hsa04730-7	Long-term depression: GNA13	1.54248586960362e-10	DOWN	-6.40151849596534	3.17121296194866e-10	Long-term depression: GNA13
P-hsa04014-43	Ras signaling pathway: ELK1	1.93742881253269e-10	UP	6.36662620349145	3.97049503460123e-10	Ras signaling pathway: ELK1
P-hsa04151-28	PI3K-Akt signaling pathway: BCL2L11	1.93742881253269e-10	DOWN	-6.36662620349145	3.97049503460123e-10	PI3K-Akt signaling pathway: BCL2L11
P-hsa04961-17	Endocrine and other factor-regulated calcium reabsorption: CALB1	2.29386485400433e-10	DOWN	-6.34065984630158	4.69348818299455e-10	Endocrine and other factor-regulated calcium reabsorption: CALB1
P-hsa04261-66	Adrenergic signaling in cardiomyocytes: C01245	2.53500692425948e-10	DOWN	-6.3252423217201	5.17865700241579e-10	Adrenergic signaling in cardiomyocytes: C01245
P-hsa04910-48	Insulin signaling pathway: PPARGC1A	2.54836222755137e-10	DOWN	-6.32443087305791	5.19768967806436e-10	Insulin signaling pathway: PPARGC1A
P-hsa04024-114	cAMP signaling pathway: HHIP	3.07770664595578e-10	UP	6.29521872121931	6.26741843883717e-10	cAMP signaling pathway: HHIP
P-hsa04914-34	Progesterone-mediated oocyte maturation: MAPK14	3.17579890596068e-10	DOWN	-6.29035002924621	6.45695606946507e-10	Progesterone-mediated oocyte maturation: MAPK14
P-hsa04024-116	cAMP signaling pathway: ACOX1	3.20916969007403e-10	DOWN	-6.28872713192184	6.51451323521338e-10	cAMP signaling pathway: ACOX1
P-hsa04660-34	T cell receptor signaling pathway: FOS	3.29410171722127e-10	DOWN	-6.28466988861092	6.67639198435241e-10	T cell receptor signaling pathway: FOS
P-hsa04010-134	MAPK signaling pathway: ATF4*	4.25149281295074e-10	DOWN	-6.24490890416393	8.6032566828107e-10	MAPK signaling pathway: ATF4*
P-hsa04921-56	Oxytocin signaling pathway: JUN	4.31820829262477e-10	DOWN	-6.24247455817738	8.72454328509903e-10	Oxytocin signaling pathway: JUN
P-hsa04930-7	Type II diabetes mellitus: C00002	4.34067303951165e-10	UP	6.2416631095152	8.75618526935971e-10	Type II diabetes mellitus: C00002
P-hsa04024-92	cAMP signaling pathway: GRIN3A	4.47787663039161e-10	DOWN	-6.2367944175421	9.01882194571832e-10	cAMP signaling pathway: GRIN3A
P-hsa04610-44	Complement and coagulation cascades: C3	4.99224108529094e-10	DOWN	-6.21975399563625	1.00390848074523e-09	Complement and coagulation cascades: C3
P-hsa04725-61	Cholinergic synapse: FOS	5.17617914515785e-10	DOWN	-6.21407385500096	1.03927341026804e-09	Cholinergic synapse: FOS
P-hsa03320-66	PPAR signaling pathway: UCP1	5.20299012735584e-10	DOWN	-6.21326240633878	1.043029329269e-09	PPAR signaling pathway: UCP1
P-hsa04022-3	cGMP-PKG signaling pathway: MYL9	5.91908730108701e-10	DOWN	-6.19297618978419	1.18473800256594e-09	cGMP-PKG signaling pathway: MYL9
P-hsa04630-35	Jak-STAT signaling pathway: MTOR	6.23169995235058e-10	DOWN	-6.18486170316236	1.24537233519801e-09	Jak-STAT signaling pathway: MTOR
P-hsa04066-61	HIF-1 signaling pathway: HMOX1	6.5604008784789e-10	DOWN	-6.17674721654052	1.30902882644998e-09	HIF-1 signaling pathway: HMOX1
P-hsa04510-19 26	Focal adhesion: VCL ACTN4	6.87065189298918e-10	DOWN	-6.16944417858087	1.3688125365754e-09	Focal adhesion: VCL ACTN4
P-hsa04072-27	Phospholipase D signaling pathway: C01245	6.94151602927078e-10	DOWN	-6.16782128125651	1.38079306486422e-09	Phospholipase D signaling pathway: C01245
P-hsa04064-94	NF-kappa B signaling pathway: BCL2L1*	7.97087774108705e-10	DOWN	-6.14591216737755	1.58310488468812e-09	NF-kappa B signaling pathway: BCL2L1*
P-hsa03320-65	PPAR signaling pathway: ME1	8.64960550673912e-10	DOWN	-6.13292898878262	1.71526075303132e-09	PPAR signaling pathway: ME1
P-hsa04726-16	Serotonergic synapse: ITPR1	1.1267963326756e-09	DOWN	-6.09073365834908	2.2276296162112e-09	Serotonergic synapse: ITPR1
P-hsa04726-46	Serotonergic synapse: ITPR1*	1.1267963326756e-09	DOWN	-6.09073365834908	2.2276296162112e-09	Serotonergic synapse: ITPR1*
P-hsa04611-34	Platelet activation: C02198*	1.32478818511501e-09	DOWN	-6.06476730115921	2.6150343469985e-09	Platelet activation: C02198*
P-hsa04921-59	Oxytocin signaling pathway: CCND1	1.36551367675702e-09	DOWN	-6.05989860918611	2.6912957151398e-09	Oxytocin signaling pathway: CCND1
P-hsa04913-35	Ovarian steroidogenesis: HSD17B2	1.45798276028431e-09	DOWN	-6.04934977657772	2.869149560376e-09	Ovarian steroidogenesis: HSD17B2
P-hsa04960-4	Aldosterone-regulated sodium reabsorption: ATP1B4	1.57227311951958e-09	DOWN	-6.03717804664497	3.08933664858274e-09	Aldosterone-regulated sodium reabsorption: ATP1B4
P-hsa04933-19	AGE-RAGE signaling pathway in diabetic complications: TGFBR2	1.72963146832762e-09	DOWN	-6.02176052206348	3.3933471032586e-09	AGE-RAGE signaling pathway in diabetic complications: TGFBR2
P-hsa04360-35	Axon guidance: ROCK1*	1.8003866461818e-09	UP	6.01526893276601	3.52678480005475e-09	Axon guidance: ROCK1*
P-hsa04919-103	Thyroid hormone signaling pathway: CCND1	1.81851146279556e-09	DOWN	-6.01364603544165	3.55687576385697e-09	Thyroid hormone signaling pathway: CCND1
P-hsa04211-2	Longevity regulating pathway - mammal: RPS6KB1	1.82764041941744e-09	UP	6.01283458677946	3.5693068585588e-09	Longevity regulating pathway - mammal: RPS6KB1
P-hsa04725-53	Cholinergic synapse: CHRNA7	1.98983992552567e-09	DOWN	-5.99903995952235	3.88018785477506e-09	Cholinergic synapse: CHRNA7
P-hsa04115-27	p53 signaling pathway: THBS1	2.27667866493197e-09	UP	5.97713084564339	4.43280702234106e-09	p53 signaling pathway: THBS1
P-hsa04010-63	MAPK signaling pathway: MAX	2.41673564070547e-09	DOWN	-5.96739346169719	4.6983969329123e-09	MAPK signaling pathway: MAX
P-hsa04152-61	AMPK signaling pathway: RPS6KB1	2.53982987407118e-09	DOWN	-5.95927897507536	4.93025799084405e-09	AMPK signaling pathway: RPS6KB1
P-hsa04151-35	PI3K-Akt signaling pathway: CCND1	2.59075894717081e-09	UP	5.95603318042662	5.02154633284463e-09	PI3K-Akt signaling pathway: CCND1
P-hsa04914-11	Progesterone-mediated oocyte maturation: CDK1	2.94688822467375e-09	UP	5.93493551520985	5.69466238011280e-09	Progesterone-mediated oocyte maturation: CDK1
P-hsa04972-21	Pancreatic secretion: KCNQ1	2.94688822467375e-09	DOWN	-5.93493551520985	5.69466238011280e-09	Pancreatic secretion: KCNQ1
P-hsa04068-39	FoxO signaling pathway: CCNB3	3.09618958974591e-09	UP	5.92682102858802	5.9742068995547e-09	FoxO signaling pathway: CCNB3
P-hsa04211-57	Longevity regulating pathway - mammal: ATG5	3.22090983550291e-09	DOWN	-5.92032943929055	6.2055553267848e-09	Longevity regulating pathway - mammal: ATG5
P-hsa04310-35	Wnt signaling pathway: JUN	3.25284622935502e-09	DOWN	-5.91870654196618	6.25771763405069e-09	Wnt signaling pathway: JUN
P-hsa04210-83	Apoptosis: TP53*	3.48519478132651e-09	DOWN	-5.90734626069561	6.69469505010032e-09	Apoptosis: TP53*
P-hsa04210-51	Apoptosis: LMNA	3.53704591291538e-09	UP	5.90491191470906	6.78417002969015e-09	Apoptosis: LMNA
P-hsa04920-12	Adipocytokine signaling pathway: C00165	3.86422216996495e-09	DOWN	-5.89030583878976	7.40067549515610e-09	Adipocytokine signaling pathway: C00165
P-hsa04919-28	Thyroid hormone signaling pathway: RCAN1	3.99935634906108e-09	DOWN	-5.88462569815448	7.6481004773278e-09	Thyroid hormone signaling pathway: RCAN1
P-hsa04012-23	ErbB signaling pathway: RPS6KB1	4.01902264271875e-09	DOWN	-5.88381424949229	7.67430584744664e-09	ErbB signaling pathway: RPS6KB1
P-hsa04540-14 31	Gap junction: GJA1 TJP1	4.76987565961026e-09	DOWN	-5.85541354631587	9.09456292432357e-09	Gap junction: GJA1 TJP1
P-hsa04024-118	cAMP signaling pathway: MYL9	4.9597724709435e-09	UP	5.8489219570184	9.44264374275781e-09	cAMP signaling pathway: MYL9
P-hsa04014-33	Ras signaling pathway: BCL2L1	5.00838423353956e-09	DOWN	-5.84729905969404	9.50706564685165e-09	Ras signaling pathway: BCL2L1
P-hsa04917-75	Prolactin signaling pathway: CCND1**	5.00838423353956e-09	DOWN	-5.84729905969404	9.50706564685165e-09	Prolactin signaling pathway: CCND1**
P-hsa04728-70 73	Dopaminergic synapse: KIF5A GRIA1	5.68411275110246e-09	UP	5.82620139447727	1.07738631968614e-08	Dopaminergic synapse: KIF5A GRIA1
P-hsa04010-58	MAPK signaling pathway: CDC25B	5.90931437644111e-09	DOWN	-5.8197098051798	1.11842464742349e-08	MAPK signaling pathway: CDC25B
P-hsa04726-64	Serotonergic synapse: CASP3	6.11346698987948e-09	UP	5.81402966454452	1.15536446636929e-08	Serotonergic synapse: CASP3
P-hsa04740-13	Olfactory transduction: CNGA3	6.17304559739208e-09	DOWN	-5.81240676722015	1.16491344337883e-08	Olfactory transduction: CNGA3
P-hsa04666-42	Fc gamma R-mediated phagocytosis: MYO10	6.47951245906154e-09	DOWN	-5.80429228059831	1.22095644726387e-08	Fc gamma R-mediated phagocytosis: MYO10
P-hsa04010-129	MAPK signaling pathway: FOS	6.51096080349953e-09	DOWN	-5.80348083193613	1.22330022687648e-08	MAPK signaling pathway: FOS
P-hsa04920-40	Adipocytokine signaling pathway: PPARGC1A	6.51096080349953e-09	UP	5.80348083193613	1.22330022687648e-08	Adipocytokine signaling pathway: PPARGC1A
P-hsa04620-19	Toll-like receptor signaling pathway: CXCL10	6.93354743512787e-09	DOWN	-5.79293199932775	1.30079818498682e-08	Toll-like receptor signaling pathway: CXCL10
P-hsa04014-61	Ras signaling pathway: RAP1A	7.20673393768959e-09	DOWN	-5.78644041003028	1.35008247129643e-08	Ras signaling pathway: RAP1A
P-hsa04911-35	Insulin secretion: TRPM4	7.27664942020746e-09	DOWN	-5.78481751270591	1.36119880869288e-08	Insulin secretion: TRPM4
P-hsa04620-34	Toll-like receptor signaling pathway: IL1B	8.16883398937568e-09	DOWN	-5.76534274481351	1.5258765376381e-08	Toll-like receptor signaling pathway: IL1B
P-hsa04950-22	Maturity onset diabetes of the young: NR5A2	8.28757293293527e-09	DOWN	-5.76290839882696	1.5458125166214e-08	Maturity onset diabetes of the young: NR5A2
P-hsa04210-63	Apoptosis: FAS*	8.32752420764472e-09	UP	5.76209695016477	1.55101644793614e-08	Apoptosis: FAS*
P-hsa03320-30	PPAR signaling pathway: LPL	8.44850477180543e-09	DOWN	-5.75966260417822	1.57127538169271e-08	PPAR signaling pathway: LPL
P-hsa04623-17	Cytosolic DNA-sensing pathway: NFKB1	8.48921005507768e-09	DOWN	-5.75885115551604	1.57656758165728e-08	Cytosolic DNA-sensing pathway: NFKB1
P-hsa04710-23	Circadian rhythm: BHLHE41	8.90689265482792e-09	DOWN	-5.75073666889421	1.65175372431751e-08	Circadian rhythm: BHLHE41
P-hsa04151-103	PI3K-Akt signaling pathway: BCL2*	9.25535990311375e-09	UP	5.74424507959674	1.71390621515214e-08	PI3K-Akt signaling pathway: BCL2*
P-hsa04917-37	Prolactin signaling pathway: TNFSF11	9.31933844221492e-09	DOWN	-5.74302790660346	1.72327422056474e-08	Prolactin signaling pathway: TNFSF11
P-hsa04014-69	Ras signaling pathway: PLCE1*	9.43452788259308e-09	UP	5.740999284948	1.7420713608174e-08	Ras signaling pathway: PLCE1*
P-hsa04924-23	Renin secretion: ITPR1	9.57111188715029e-09	DOWN	-5.73856493896145	1.76475945541009e-08	Renin secretion: ITPR1
P-hsa04931-47	Insulin resistance: AKT2*	9.8500699386159e-09	UP	5.73369624698835	1.81359656809709e-08	Insulin resistance: AKT2*
P-hsa03460-28	Fanconi anemia pathway: RAD51C	9.94480013733012e-09	UP	5.73207334966399	1.82842253953484e-08	Fanconi anemia pathway: RAD51C
P-hsa04024-111	cAMP signaling pathway: JUN	1.02833802298402e-08	DOWN	-5.7263932090287	1.88797579968679e-08	cAMP signaling pathway: JUN
P-hsa04923-16	Regulation of lipolysis in adipocytes: PLIN1	1.12062775464468e-08	DOWN	-5.7117871331094	2.05448421684858e-08	Regulation of lipolysis in adipocytes: PLIN1
P-hsa04310-33	Wnt signaling pathway: CCND1	1.18657419400958e-08	DOWN	-5.7020497491632	2.17229158988666e-08	Wnt signaling pathway: CCND1
P-hsa04670-28 41 49	Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1	1.30495338382006e-08	DOWN	-5.68582077591953	2.38561790479604e-08	Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1
P-hsa04650-39	Natural killer cell mediated cytotoxicity: FAS	1.32367207386918e-08	DOWN	-5.68338642993298	2.41640561570161e-08	Natural killer cell mediated cytotoxicity: FAS
P-hsa04151-110	PI3K-Akt signaling pathway: BCL2**	1.38140682483505e-08	UP	5.67608339197333	2.51823028833244e-08	PI3K-Akt signaling pathway: BCL2**
P-hsa04742-49	Taste transduction: HTR1A	1.41000701306574e-08	DOWN	-4.2446879518817	2.56673129535446e-08	Taste transduction: HTR1A
P-hsa04151-5	PI3K-Akt signaling pathway: EIF4B	1.44158494099147e-08	DOWN	-5.66878035401368	2.62050821900569e-08	PI3K-Akt signaling pathway: EIF4B
P-hsa04115-54	p53 signaling pathway: PERP	1.51143702217852e-08	UP	5.66066586739184	2.74360994011813e-08	p53 signaling pathway: PERP
P-hsa04068-58	FoxO signaling pathway: KLF2	1.63009105808826e-08	DOWN	-5.64768268879691	2.95067115578001e-08	FoxO signaling pathway: KLF2
P-hsa04340-33	Hedgehog signaling pathway: HHIP*	1.63009105808826e-08	UP	5.64768268879691	2.95067115578001e-08	Hedgehog signaling pathway: HHIP*
P-hsa04722-35	Neurotrophin signaling pathway: FOXO3	1.68480250434685e-08	DOWN	-5.64200254816162	3.04542250434606e-08	Neurotrophin signaling pathway: FOXO3
P-hsa04310-13	Wnt signaling pathway: NFATC1	1.74951469979971e-08	UP	5.63551095886415	3.15795991394422e-08	Wnt signaling pathway: NFATC1
P-hsa04014-44	Ras signaling pathway: ETS1	1.84244839311534e-08	DOWN	-5.62658502358014	3.32105193548942e-08	Ras signaling pathway: ETS1
P-hsa04911-4	Insulin secretion: CACNA1C	2.01437906877809e-08	DOWN	-5.61116749899865	3.62588232380056e-08	Insulin secretion: CACNA1C
P-hsa04024-78	cAMP signaling pathway: LIPE	2.23295176783868e-08	DOWN	-5.59331562843061	4.01369961621282e-08	cAMP signaling pathway: LIPE
P-hsa04360-81	Axon guidance: FYN*	2.27509262224638e-08	UP	5.59006983378188	4.08374366085229e-08	Axon guidance: FYN*
P-hsa04730-30	Long-term depression: C00025*	2.38385017806128e-08	DOWN	-5.58195534716005	4.2730016422909e-08	Long-term depression: C00025*
P-hsa04010-65	MAPK signaling pathway: ELK4	2.41744996883135e-08	DOWN	-5.57952100117349	4.32720182181634e-08	MAPK signaling pathway: ELK4
P-hsa04014-64	Ras signaling pathway: PIK3R5*	2.44010470472637e-08	DOWN	-5.57789810384913	4.36168715969839e-08	Ras signaling pathway: PIK3R5*
P-hsa04270-10 3 71	Vascular smooth muscle contraction: ACTA2 MYL9 MYH11	2.54462650448481e-08	DOWN	-5.57059506588948	4.54221125003045e-08	Vascular smooth muscle contraction: ACTA2 MYL9 MYH11
P-hsa04520-44 49	Adherens junction: ACTB VCL	2.58042297955428e-08	DOWN	-5.56816071990293	4.59972905081214e-08	Adherens junction: ACTB VCL
P-hsa04024-43	cAMP signaling pathway: MAPK8	2.65348782498424e-08	DOWN	-5.56329202792983	4.72342853493045e-08	cAMP signaling pathway: MAPK8
P-hsa04650-116	Natural killer cell mediated cytotoxicity: FCGR3A	2.80568853153441e-08	UP	5.55355464398362	4.98746013823865e-08	Natural killer cell mediated cytotoxicity: FCGR3A
P-hsa04910-9	Insulin signaling pathway: ELK1	2.89834894022979e-08	DOWN	-5.54787450334834	5.14506908424239e-08	Insulin signaling pathway: ELK1
P-hsa04610-46	Complement and coagulation cascades: C2	3.3611318072351e-08	DOWN	-5.52190814615847	5.95017418969956e-08	Complement and coagulation cascades: C2
P-hsa04620-87	Toll-like receptor signaling pathway: CCL4L1	3.3611318072351e-08	DOWN	-5.52190814615847	5.95017418969956e-08	Toll-like receptor signaling pathway: CCL4L1
P-hsa04014-104	Ras signaling pathway: BRAP*	3.63536176305182e-08	DOWN	-5.50811351890135	6.4268002596809e-08	Ras signaling pathway: BRAP*
P-hsa04917-57	Prolactin signaling pathway: ESR1	4.05974273627536e-08	DOWN	-5.48863875100895	7.16720013935032e-08	Prolactin signaling pathway: ESR1
P-hsa04620-12	Toll-like receptor signaling pathway: NFKB1	4.36894739425567e-08	DOWN	-5.47565557241401	7.7025141046672e-08	Toll-like receptor signaling pathway: NFKB1
P-hsa04115-43 57	p53 signaling pathway: CDK1 CCNB3	4.51129470333395e-08	UP	5.46997543177873	7.94259409465224e-08	p53 signaling pathway: CDK1 CCNB3
P-hsa04012-29	ErbB signaling pathway: STAT5A*	4.57366785613258e-08	DOWN	-5.46754108579218	8.04140782901999e-08	ErbB signaling pathway: STAT5A*
P-hsa04270-17	Vascular smooth muscle contraction: ITPR1	4.6581338506336e-08	DOWN	-5.46429529114344	8.17874251809746e-08	Vascular smooth muscle contraction: ITPR1
P-hsa04750-44	Inflammatory mediator regulation of TRP channels: TRPA1	5.25648345728945e-08	DOWN	-5.44279190159558	9.20420980888642e-08	Inflammatory mediator regulation of TRP channels: TRPA1
P-hsa04750-63	Inflammatory mediator regulation of TRP channels: TRPA1*	5.25648345728945e-08	DOWN	-5.44279190159558	9.20420980888642e-08	Inflammatory mediator regulation of TRP channels: TRPA1*
P-hsa04620-77	Toll-like receptor signaling pathway: CXCL9	5.59037372351181e-08	DOWN	-5.4318373446561	9.7755583996735e-08	Toll-like receptor signaling pathway: CXCL9
P-hsa04620-22	Toll-like receptor signaling pathway: CD86	5.82379494615722e-08	DOWN	-5.42453430669645	1.01699105776178e-07	Toll-like receptor signaling pathway: CD86
P-hsa04915-3 11	Estrogen signaling pathway: ESR1 C00951	5.95752572064976e-08	DOWN	-5.42047706338554	1.03612643276706e-07	Estrogen signaling pathway: ESR1 C00951
P-hsa04915-12 14	Estrogen signaling pathway: ESR1 FOS	5.95752572064976e-08	DOWN	-5.42047706338554	1.03612643276706e-07	Estrogen signaling pathway: ESR1 FOS
P-hsa04915-12 13	Estrogen signaling pathway: ESR1 C00951*	5.95752572064976e-08	DOWN	-5.42047706338554	1.03612643276706e-07	Estrogen signaling pathway: ESR1 C00951*
P-hsa04668-116	TNF signaling pathway: PGAM5	6.03918735421274e-08	DOWN	-5.41804271739899	1.04891148783695e-07	TNF signaling pathway: PGAM5
P-hsa04810-31	Regulation of actin cytoskeleton: MSN	6.94910298893751e-08	DOWN	-5.3928878088713	1.205322849968e-07	Regulation of actin cytoskeleton: MSN
P-hsa04726-71	Serotonergic synapse: CACNA1A	7.01216063800453e-08	UP	5.39126491154693	1.21462324914022e-07	Serotonergic synapse: CACNA1A
P-hsa04024-77	cAMP signaling pathway: RHOA*	7.77835505791242e-08	UP	5.37260159231671	1.3455299676792e-07	cAMP signaling pathway: RHOA*
P-hsa04024-7	cAMP signaling pathway: TNNI3	8.28378857957391e-08	DOWN	-5.36124131104614	1.43103837609552e-07	cAMP signaling pathway: TNNI3
P-hsa04151-4	PI3K-Akt signaling pathway: RPS6	8.51000907022233e-08	DOWN	-5.35637261907304	1.46814767739626e-07	PI3K-Akt signaling pathway: RPS6
P-hsa04071-89	Sphingolipid signaling pathway: C00533	8.5482894799081e-08	DOWN	-5.35556117041086	1.4727775850926e-07	Sphingolipid signaling pathway: C00533
P-hsa04622-21 22 23	RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG	8.86059341176482e-08	DOWN	-5.34906958111339	1.52454327820071e-07	RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG
P-hsa04620-76	Toll-like receptor signaling pathway: CCL3L3	9.86522454254658e-08	DOWN	-5.32959481322099	1.69513270844559e-07	Toll-like receptor signaling pathway: CCL3L3
P-hsa04115-3	p53 signaling pathway: GADD45G	9.90939207294821e-08	UP	5.3287833645588	1.70045167971791e-07	p53 signaling pathway: GADD45G
P-hsa04917-31	Prolactin signaling pathway: GALT	1.08340160333056e-07	DOWN	-5.31255439131514	1.85664162914306e-07	Prolactin signaling pathway: GALT
P-hsa04024-110	cAMP signaling pathway: FOS	1.08823748925501e-07	DOWN	-5.31174294265295	1.86244900089254e-07	cAMP signaling pathway: FOS
P-hsa04360-21	Axon guidance: PAK4	1.16851230199034e-07	UP	5.29875976405802	1.99717839662891e-07	Axon guidance: PAK4
P-hsa04917-56	Prolactin signaling pathway: LHCGR	1.18804629602885e-07	DOWN	-5.29023955310509	2.02787212598028e-07	Prolactin signaling pathway: LHCGR
P-hsa04933-61	AGE-RAGE signaling pathway in diabetic complications: MMP2	1.26567350596167e-07	DOWN	-5.28415368813871	2.1575123207585e-07	AGE-RAGE signaling pathway in diabetic complications: MMP2
P-hsa04152-35	AMPK signaling pathway: PFKFB1	1.51704554971173e-07	UP	5.25088429298919	2.58258944772354e-07	AMPK signaling pathway: PFKFB1
P-hsa04620-29	Toll-like receptor signaling pathway: CXCL8	1.52374307725448e-07	DOWN	-5.25007284432701	2.59056451839699e-07	Toll-like receptor signaling pathway: CXCL8
P-hsa04360-111	Axon guidance: RHOA***	1.550820277975e-07	UP	5.24682704967827	2.63312097329001e-07	Axon guidance: RHOA***
P-hsa04972-39	Pancreatic secretion: KCNMA1*	1.55766194231071e-07	DOWN	-5.24601560101609	2.64125285870078e-07	Pancreatic secretion: KCNMA1*
P-hsa04110-60 10 11 12 13 14 9	Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6	1.67853471005585e-07	UP	5.23222097375897	2.84246601558141e-07	Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6
P-hsa04066-55	HIF-1 signaling pathway: ANGPT1	1.73089900636576e-07	DOWN	-5.22654083312369	2.92728912114682e-07	HIF-1 signaling pathway: ANGPT1
P-hsa04621-28	NOD-like receptor signaling pathway: CASP8	1.74614804608831e-07	DOWN	-5.22491793579932	2.94920280225151e-07	NOD-like receptor signaling pathway: CASP8
P-hsa04064-95	NF-kappa B signaling pathway: BCL2L1**	1.84847975447684e-07	DOWN	-5.21436910319094	3.11794684667325e-07	NF-kappa B signaling pathway: BCL2L1**
P-hsa04662-6	B cell receptor signaling pathway: NFKB1	1.9480682160442e-07	DOWN	-5.20463171924473	3.28162800268178e-07	B cell receptor signaling pathway: NFKB1
P-hsa04921-57	Oxytocin signaling pathway: FOS	1.95659743806826e-07	DOWN	-5.20382027058255	3.29168745463249e-07	Oxytocin signaling pathway: FOS
P-hsa04010-120	MAPK signaling pathway: NFATC1	1.99978783407153e-07	DOWN	-5.19976302727163	3.35995684392957e-07	MAPK signaling pathway: NFATC1
P-hsa04152-57	AMPK signaling pathway: ACACA*	2.11643940086981e-07	DOWN	-5.18921419466325	3.55131357095103e-07	AMPK signaling pathway: ACACA*
P-hsa04014-70	Ras signaling pathway: RIN1*	2.20102177811215e-07	UP	5.1819111567036	3.688431026602e-07	Ras signaling pathway: RIN1*
P-hsa04014-63	Ras signaling pathway: TIAM1*	2.24941383816242e-07	UP	5.17785391339268	3.76462367973346e-07	Ras signaling pathway: TIAM1*
P-hsa04064-54	NF-kappa B signaling pathway: CCL13	2.40083802808197e-07	DOWN	-5.16568218345993	4.01282927550844e-07	NF-kappa B signaling pathway: CCL13
P-hsa04152-15	AMPK signaling pathway: FOXO1	2.42175729752361e-07	DOWN	-5.16405928613556	4.0425442826367e-07	AMPK signaling pathway: FOXO1
P-hsa04152-81	AMPK signaling pathway: LIPE	2.59557009177544e-07	UP	5.15107610754063	4.32707086543392e-07	AMPK signaling pathway: LIPE
P-hsa04110-46	Cell cycle: RB1	2.63995347670769e-07	DOWN	-5.1474245885608	4.39536885449262e-07	Cell cycle: RB1
P-hsa04622-5 33	RIG-I-like receptor signaling pathway: MAVS TMEM173	2.65231520574798e-07	DOWN	-5.14701886422971	4.41024505141814e-07	RIG-I-like receptor signaling pathway: MAVS TMEM173
P-hsa04750-90	Inflammatory mediator regulation of TRP channels: C01245**	2.74560797012979e-07	DOWN	-5.14052727493224	4.55948059039618e-07	Inflammatory mediator regulation of TRP channels: C01245**
P-hsa04022-49	cGMP-PKG signaling pathway: ATP1B4	2.79343502348678e-07	DOWN	-5.13728148028351	4.63292638560244e-07	cGMP-PKG signaling pathway: ATP1B4
P-hsa04915-21	Estrogen signaling pathway: CREB3	2.86668737604076e-07	DOWN	-5.13241278831041	4.74829685066211e-07	Estrogen signaling pathway: CREB3
P-hsa04931-67	Insulin resistance: IKBKB**	3.11109629660672e-07	DOWN	-5.11699526372892	5.14650505621188e-07	Insulin resistance: IKBKB**
P-hsa04014-30	Ras signaling pathway: C01245	3.3755658961371e-07	UP	5.10157773914743	5.57683351518414e-07	Ras signaling pathway: C01245
P-hsa04925-3	Aldosterone synthesis and secretion: ITPR1	3.55364389808694e-07	DOWN	-5.09184035520123	5.86351243184345e-07	Aldosterone synthesis and secretion: ITPR1
P-hsa04115-30	p53 signaling pathway: SERPINE1	3.77287179325266e-07	UP	5.08048007393066	6.21726760296566e-07	p53 signaling pathway: SERPINE1
P-hsa04917-46	Prolactin signaling pathway: GCK	3.88732426433989e-07	DOWN	-5.07479993329538	6.39768072660543e-07	Prolactin signaling pathway: GCK
P-hsa04664-23	Fc epsilon RI signaling pathway: AKT3	4.17940105907853e-07	DOWN	-5.06100530603826	6.86959024653138e-07	Fc epsilon RI signaling pathway: AKT3
P-hsa04724-36	Glutamatergic synapse: TRPC1	4.30572476380671e-07	UP	5.05532516540298	7.06819868752454e-07	Glutamatergic synapse: TRPC1
P-hsa04390-17 51	Hippo signaling pathway: YWHAQ YAP1	4.86942993034968e-07	DOWN	-5.03179315419966	7.98338384759241e-07	Hippo signaling pathway: YWHAQ YAP1
P-hsa04510-43	Focal adhesion: BAD	4.97355572228602e-07	UP	5.02773591088874	8.14372291931566e-07	Focal adhesion: BAD
P-hsa04330-12	Notch signaling pathway: HES1	5.0583992128965e-07	DOWN	-5.02449011624001	8.27212171156009e-07	Notch signaling pathway: HES1
P-hsa04620-21	Toll-like receptor signaling pathway: IFNA1	5.6448828991276e-07	DOWN	-5.00339245102324	9.21949783144317e-07	Toll-like receptor signaling pathway: IFNA1
P-hsa04620-20	Toll-like receptor signaling pathway: IFNB1*	5.66870139599144e-07	DOWN	-5.00258100236105	9.2466650147541e-07	Toll-like receptor signaling pathway: IFNB1*
P-hsa04151-51	PI3K-Akt signaling pathway: NOS3	5.88747296787681e-07	UP	4.9952779644014	9.59136418943982e-07	PI3K-Akt signaling pathway: NOS3
P-hsa04620-18	Toll-like receptor signaling pathway: CXCL11	5.96218886452163e-07	DOWN	-4.99284361841485	9.70080539650991e-07	Toll-like receptor signaling pathway: CXCL11
P-hsa04520-18	Adherens junction: SNAI2	6.08875083787331e-07	DOWN	-4.98878637510393	9.89422011154412e-07	Adherens junction: SNAI2
P-hsa04919-49	Thyroid hormone signaling pathway: ACTB	6.11437213342485e-07	UP	4.98797492644175	9.92332526572229e-07	Thyroid hormone signaling pathway: ACTB
P-hsa04920-6	Adipocytokine signaling pathway: PTPN11	6.40315372187772e-07	DOWN	-4.97904899115773	1.03658601761719e-06	Adipocytokine signaling pathway: PTPN11
P-hsa04921-46	Oxytocin signaling pathway: C00942*	6.40315372187772e-07	DOWN	-4.97904899115773	1.03658601761719e-06	Oxytocin signaling pathway: C00942*
P-hsa04022-58	cGMP-PKG signaling pathway: MYH7	6.4841661876065e-07	DOWN	-4.97661464517118	1.04838214616201e-06	cGMP-PKG signaling pathway: MYH7
P-hsa04350-41	TGF-beta signaling pathway: SMAD4***	6.78974729624902e-07	DOWN	-4.96768870988716	1.09641214181587e-06	TGF-beta signaling pathway: SMAD4***
P-hsa04022-39	cGMP-PKG signaling pathway: KCNJ8	7.69533599673625e-07	DOWN	-4.94334525002166	1.24108990323303e-06	cGMP-PKG signaling pathway: KCNJ8
P-hsa04012-57	ErbB signaling pathway: ABL1	7.92280646935797e-07	DOWN	-4.93766510938638	1.27617671164752e-06	ErbB signaling pathway: ABL1
P-hsa04650-36	Natural killer cell mediated cytotoxicity: CASP3	8.15674647388015e-07	DOWN	-4.93198496875109	1.31221658898547e-06	Natural killer cell mediated cytotoxicity: CASP3
P-hsa04151-109	PI3K-Akt signaling pathway: RXRA	8.68065725658127e-07	UP	4.91981323881834	1.39475728954059e-06	PI3K-Akt signaling pathway: RXRA
P-hsa04611-43	Platelet activation: MYL12B	8.97317617293151e-07	DOWN	-4.91332164952087	1.43995981727716e-06	Platelet activation: MYL12B
P-hsa04152-33	AMPK signaling pathway: CPT1C	9.01040161817247e-07	UP	4.91251020085869	1.4423366769388e-06	AMPK signaling pathway: CPT1C
P-hsa04922-60	Glucagon signaling pathway: CPT1C*	9.01040161817247e-07	UP	4.91251020085869	1.4423366769388e-06	Glucagon signaling pathway: CPT1C*
P-hsa04024-112	cAMP signaling pathway: GLI1	9.23689642918126e-07	DOWN	-4.90764150888559	1.47675598811879e-06	cAMP signaling pathway: GLI1
P-hsa04014-97	Ras signaling pathway: PAK4	9.66645205314182e-07	DOWN	-4.89871557360157	1.54351411816297e-06	Ras signaling pathway: PAK4
P-hsa04020-16	Calcium signaling pathway: C06124	1.04972183451711e-06	UP	4.8824866003579	1.6740916989139e-06	Calcium signaling pathway: C06124
P-hsa04270-65	Vascular smooth muscle contraction: NPR2	1.10736130326341e-06	DOWN	-4.87193776774951	1.76382920457922e-06	Vascular smooth muscle contraction: NPR2
P-hsa04152-63	AMPK signaling pathway: PPARG	1.18249226646371e-06	DOWN	-4.85895458915458	1.88117125703189e-06	AMPK signaling pathway: PPARG
P-hsa04915-40	Estrogen signaling pathway: CREB3**	1.25223381238006e-06	DOWN	-4.84759430788401	1.98966039078165e-06	Estrogen signaling pathway: CREB3**
P-hsa04727-49	GABAergic synapse: GABRR3	1.35874917845134e-06	DOWN	-4.83136533464034	2.15623944841785e-06	GABAergic synapse: GABRR3
P-hsa04012-35	ErbB signaling pathway: CBLC	1.46800818537921e-06	DOWN	-4.81594781005886	2.32675681598896e-06	ErbB signaling pathway: CBLC
P-hsa04621-29	NOD-like receptor signaling pathway: CASP5	1.51034574582835e-06	DOWN	-4.81026766942357	2.39091632826701e-06	NOD-like receptor signaling pathway: CASP5
P-hsa04921-80	Oxytocin signaling pathway: KCNJ2	1.58566975099887e-06	UP	4.80053028547737	2.50707244414686e-06	Oxytocin signaling pathway: KCNJ2
P-hsa04350-10	TGF-beta signaling pathway: SMAD4	1.79011036844258e-06	DOWN	-4.77618682561187	2.82683686403141e-06	TGF-beta signaling pathway: SMAD4
P-hsa04068-41	FoxO signaling pathway: CDKN2B	1.94023011837161e-06	DOWN	-4.7599578523682	3.06014235581405e-06	FoxO signaling pathway: CDKN2B
P-hsa04066-54	HIF-1 signaling pathway: SERPINE1	1.95589040788184e-06	DOWN	-4.75833495504383	3.08106604032305e-06	HIF-1 signaling pathway: SERPINE1
P-hsa04540-14 16	Gap junction: GJA1 GJA1	2.01166329112161e-06	DOWN	-4.75265481440855	3.16118517176252e-06	Gap junction: GJA1 GJA1
P-hsa04540-14 15	Gap junction: GJA1 GJA1*	2.01166329112161e-06	DOWN	-4.75265481440855	3.16118517176252e-06	Gap junction: GJA1 GJA1*
P-hsa04064-93	NF-kappa B signaling pathway: PLAU	2.04421611974333e-06	DOWN	-4.74940901975981	3.20842212940203e-06	NF-kappa B signaling pathway: PLAU
P-hsa04510-19 23	Focal adhesion: VCL TLN1	2.11084627466723e-06	DOWN	-4.74291743046234	3.30896364859529e-06	Focal adhesion: VCL TLN1
P-hsa04022-51	cGMP-PKG signaling pathway: GTF2I	2.1708544281891e-06	DOWN	-4.73723728982706	3.39889251712818e-06	cGMP-PKG signaling pathway: GTF2I
P-hsa04620-23	Toll-like receptor signaling pathway: CD40	2.486393418074e-06	DOWN	-4.70964803531282	3.88819967079129e-06	Toll-like receptor signaling pathway: CD40
P-hsa04115-37	p53 signaling pathway: FAS	2.50626466799491e-06	UP	4.70802513798846	3.91451775207458e-06	p53 signaling pathway: FAS
P-hsa04932-58	Non-alcoholic fatty liver disease (NAFLD): BAX	2.62873183181129e-06	UP	4.69828775404225	4.10082165762562e-06	Non-alcoholic fatty liver disease (NAFLD): BAX
P-hsa04620-48	Toll-like receptor signaling pathway: CD80	2.76788131309567e-06	DOWN	-4.68773892143387	4.31266737282582e-06	Toll-like receptor signaling pathway: CD80
P-hsa04370-38	VEGF signaling pathway: BAD	2.84570808051003e-06	UP	4.68205878079858	4.42856868151924e-06	VEGF signaling pathway: BAD
P-hsa04925-33	Aldosterone synthesis and secretion: CYP11B2	3.29322434413257e-06	DOWN	-4.6520351802978	5.11881610011911e-06	Aldosterone synthesis and secretion: CYP11B2
P-hsa04970-27	Salivary secretion: PRKCA	3.33232875338708e-06	DOWN	-4.64960083431125	5.17334994645256e-06	Salivary secretion: PRKCA
P-hsa04022-23	cGMP-PKG signaling pathway: CACNA1C	3.57647280791131e-06	UP	4.63499475839194	5.54568735395404e-06	cGMP-PKG signaling pathway: CACNA1C
P-hsa04726-38	Serotonergic synapse: PLA2G4B	3.66159912145513e-06	DOWN	-4.63012606641884	5.67085206896841e-06	Serotonergic synapse: PLA2G4B
P-hsa04022-65	cGMP-PKG signaling pathway: PDE2A	3.69040373880192e-06	DOWN	-4.62850316909448	5.70859328345922e-06	cGMP-PKG signaling pathway: PDE2A
P-hsa04062-42	Chemokine signaling pathway: PAK1	3.82273454127718e-06	UP	4.62120013113482	5.90619370302969e-06	Chemokine signaling pathway: PAK1
P-hsa04010-54	MAPK signaling pathway: NR4A1	4.13328046932294e-06	DOWN	-4.60497115789116	6.37833568827172e-06	MAPK signaling pathway: NR4A1
P-hsa04919-27	Thyroid hormone signaling pathway: GATA4	4.19822595752679e-06	UP	4.60172536324242	6.47079857166106e-06	Thyroid hormone signaling pathway: GATA4
P-hsa04664-46	Fc epsilon RI signaling pathway: PLA2G4B	4.41612064569563e-06	DOWN	-4.59117653063404	6.79850152034723e-06	Fc epsilon RI signaling pathway: PLA2G4B
P-hsa04972-42	Pancreatic secretion: CFTR	4.55555151536007e-06	DOWN	-4.58468494133657	7.00477276017731e-06	Pancreatic secretion: CFTR
P-hsa04022-66	cGMP-PKG signaling pathway: PDE3A	4.71745153417879e-06	UP	4.57738190337692	7.24505981442494e-06	cGMP-PKG signaling pathway: PDE3A
P-hsa04211-29	Longevity regulating pathway - mammal: EIF4E	5.17657427574433e-06	DOWN	-4.55790713548451	7.94070452071866e-06	Longevity regulating pathway - mammal: EIF4E
P-hsa04152-38	AMPK signaling pathway: PFKL	5.380243532228e-06	UP	4.54979264886268	8.24330169759218e-06	AMPK signaling pathway: PFKL
P-hsa04917-44	Prolactin signaling pathway: PRLR**	5.51671285890683e-06	DOWN	-4.54451823255849	8.44234179478369e-06	Prolactin signaling pathway: PRLR**
P-hsa04932-35	Non-alcoholic fatty liver disease (NAFLD): PRKAG2	5.78854187543317e-06	DOWN	-4.53437512428119	8.84780688085807e-06	Non-alcoholic fatty liver disease (NAFLD): PRKAG2
P-hsa04910-18	Insulin signaling pathway: LIPE	5.99214303112811e-06	DOWN	-4.52707208632154	9.14814718987175e-06	Insulin signaling pathway: LIPE
P-hsa04211-56	Longevity regulating pathway - mammal: CAT	6.03830946612675e-06	DOWN	-4.52544918899718	9.20770649633309e-06	Longevity regulating pathway - mammal: CAT
P-hsa04662-16	B cell receptor signaling pathway: VAV3	6.74719285042163e-06	DOWN	-4.50191717779385	1.02764937260268e-05	B cell receptor signaling pathway: VAV3
P-hsa04950-21	Maturity onset diabetes of the young: PKLR	7.00959433237074e-06	DOWN	-4.49380269117202	1.06635318035002e-05	Maturity onset diabetes of the young: PKLR
P-hsa04152-89	AMPK signaling pathway: CFTR	8.06792880341998e-06	UP	4.46377909067123	1.22590606493524e-05	AMPK signaling pathway: CFTR
P-hsa04012-43	ErbB signaling pathway: PTK2	8.28463488178947e-06	DOWN	-4.45809895003595	1.25734965717725e-05	ErbB signaling pathway: PTK2
P-hsa04662-36	B cell receptor signaling pathway: CD79A	8.57144136872264e-06	DOWN	-4.4507959120763	1.29934570571802e-05	B cell receptor signaling pathway: CD79A
P-hsa04068-50	FoxO signaling pathway: TNFSF10	8.83432538530212e-06	DOWN	-4.44430432277883	1.33762079657457e-05	FoxO signaling pathway: TNFSF10
P-hsa04270-46	Vascular smooth muscle contraction: ITPR1*	9.38338913592047e-06	UP	4.43132114418389	1.41908599505636e-05	Vascular smooth muscle contraction: ITPR1*
P-hsa04390-52	Hippo signaling pathway: ITGB2	9.6700013413257e-06	DOWN	-4.42482955488643	1.46071499134814e-05	Hippo signaling pathway: ITGB2
P-hsa04068-42	FoxO signaling pathway: CDKN2D	1.0040037461183e-05	DOWN	-4.41671506826459	1.51483331917263e-05	FoxO signaling pathway: CDKN2D
P-hsa03320-55	PPAR signaling pathway: SCD	1.14445827487607e-05	UP	4.38831436508817	1.7247281027699e-05	PPAR signaling pathway: SCD
P-hsa04022-45	cGMP-PKG signaling pathway: CREB3	1.18349917317053e-05	DOWN	-4.38101132712852	1.77939653723187e-05	cGMP-PKG signaling pathway: CREB3
P-hsa04930-10	Type II diabetes mellitus: C00031	1.18349917317053e-05	UP	4.38101132712852	1.77939653723187e-05	Type II diabetes mellitus: C00031
P-hsa04960-13	Aldosterone-regulated sodium reabsorption: FXYD4	1.24214239151143e-05	DOWN	-4.37046249452013	1.86538769880421e-05	Aldosterone-regulated sodium reabsorption: FXYD4
P-hsa04725-18	Cholinergic synapse: ITPR1	1.30355225767785e-05	DOWN	-4.35991366191175	1.95532838651678e-05	Cholinergic synapse: ITPR1
P-hsa04012-8	ErbB signaling pathway: STAT5A	1.32302316076825e-05	UP	4.35666786726302	1.98222445623834e-05	ErbB signaling pathway: STAT5A
P-hsa04962-22	Vasopressin-regulated water reabsorption: ARHGDIA	1.37800905837401e-05	DOWN	-4.347741931979	2.06220657921786e-05	Vasopressin-regulated water reabsorption: ARHGDIA
P-hsa04510-42	Focal adhesion: BIRC2	1.38823788996311e-05	DOWN	-4.34611903465463	2.07510123621664e-05	Focal adhesion: BIRC2
P-hsa04014-54	Ras signaling pathway: RHOA	1.51119672699342e-05	DOWN	-4.32745571542441	2.2562763197686e-05	Ras signaling pathway: RHOA
P-hsa04152-64	AMPK signaling pathway: ACACB	1.51677163120839e-05	DOWN	-4.32664426676223	2.26197576983221e-05	AMPK signaling pathway: ACACB
P-hsa04917-65	Prolactin signaling pathway: CYP17A1	1.52433048285575e-05	DOWN	-4.2641627197741	2.27061728175388e-05	Prolactin signaling pathway: CYP17A1
P-hsa04916-6	Melanogenesis: DCT	1.68107198488561e-05	UP	4.30392370422109	2.50120190121131e-05	Melanogenesis: DCT
P-hsa04740-21	Olfactory transduction: PDE1A	1.69964891419396e-05	DOWN	-4.30148935823454	2.52592165423513e-05	Olfactory transduction: PDE1A
P-hsa04931-149	Insulin resistance: ACACB*	1.80207595750753e-05	DOWN	-4.2885061796396	2.67505393000252e-05	Insulin resistance: ACACB*
P-hsa03320-26	PPAR signaling pathway: CPT2	2.17712745936569e-05	DOWN	-4.24631084920606	3.22806801866779e-05	PPAR signaling pathway: CPT2
P-hsa04710-5	Circadian rhythm: RORA	2.31508614050882e-05	DOWN	-4.23251622194895	3.42867187898142e-05	Circadian rhythm: RORA
P-hsa04022-44	cGMP-PKG signaling pathway: BAD	2.54228303074623e-05	DOWN	-4.21141855673218	3.76082558686252e-05	cGMP-PKG signaling pathway: BAD
P-hsa04014-27	Ras signaling pathway: ABL1	2.91281278853833e-05	UP	4.1805835075692	4.30400695619843e-05	Ras signaling pathway: ABL1
P-hsa04152-103	AMPK signaling pathway: ULK1	2.92322472802357e-05	UP	4.17977205890702	4.31443833138341e-05	AMPK signaling pathway: ULK1
P-hsa04662-35	B cell receptor signaling pathway: CD79B	2.94415483138902e-05	DOWN	-4.17814916158265	4.34035196792402e-05	B cell receptor signaling pathway: CD79B
P-hsa04971-49	Gastric acid secretion: KCNJ1	2.96522732399976e-05	DOWN	-4.17652626425829	4.36641597939095e-05	Gastric acid secretion: KCNJ1
P-hsa04622-45	RIG-I-like receptor signaling pathway: MAPK14	3.1167990374722e-05	DOWN	-4.16516598298772	4.58436612711625e-05	RIG-I-like receptor signaling pathway: MAPK14
P-hsa04742-4	Taste transduction: TRPM5	3.18398719781754e-05	DOWN	-4.16029729101462	4.67784420501276e-05	Taste transduction: TRPM5
P-hsa04015-27	Rap1 signaling pathway: RALA	3.94985942502801e-05	DOWN	-4.11079892262143	5.79642996580507e-05	Rap1 signaling pathway: RALA
P-hsa04728-36	Dopaminergic synapse: TH	4.00575608314527e-05	UP	4.10755312797269	5.87176318793617e-05	Dopaminergic synapse: TH
P-hsa04922-59	Glucagon signaling pathway: CPT1C	4.23693933612823e-05	UP	4.09456994937776	6.20357329419458e-05	Glucagon signaling pathway: CPT1C
P-hsa04917-33	Prolactin signaling pathway: CSN2	4.38231299858054e-05	DOWN	-3.9306573196167	6.40185792187645e-05	Prolactin signaling pathway: CSN2
P-hsa04917-45	Prolactin signaling pathway: SLC2A2	4.38231299858054e-05	DOWN	-3.9306573196167	6.40185792187645e-05	Prolactin signaling pathway: SLC2A2
P-hsa04970-45	Salivary secretion: KCNMA1	4.4185744380255e-05	DOWN	-4.08483256543156	6.44751167997598e-05	Salivary secretion: KCNMA1
P-hsa04550-9	Signaling pathways regulating pluripotency of stem cells: HNF1A	4.7543368679879e-05	UP	4.0677921435257	6.92959405334136e-05	Signaling pathways regulating pluripotency of stem cells: HNF1A
P-hsa04360-4	Axon guidance: GNAI1*	5.04371961767625e-05	DOWN	-4.05399751626858	7.34306238455807e-05	Axon guidance: GNAI1*
P-hsa04010-61	MAPK signaling pathway: ATF4	5.14978294258661e-05	DOWN	-4.04912882429548	7.48900638091408e-05	MAPK signaling pathway: ATF4
P-hsa04360-101 103	Axon guidance: DPYSL2 DPYSL5	5.81185505839955e-05	DOWN	-4.02072812111906	8.44227704307023e-05	Axon guidance: DPYSL2 DPYSL5
P-hsa04810-32	Regulation of actin cytoskeleton: PXN	6.6443125992315e-05	UP	3.98908162329391	9.64062042301121e-05	Regulation of actin cytoskeleton: PXN
P-hsa04068-48	FoxO signaling pathway: FASLG	7.11380599130633e-05	DOWN	-3.97285265005024	0.000103102120617244	FoxO signaling pathway: FASLG
P-hsa04922-24	Glucagon signaling pathway: PFKL	7.13808876194816e-05	DOWN	-3.97204120138805	0.000103337685451375	Glucagon signaling pathway: PFKL
P-hsa04933-26	AGE-RAGE signaling pathway in diabetic complications: IL6	7.79757771339109e-05	DOWN	-3.95094353617128	0.000112758230529599	AGE-RAGE signaling pathway in diabetic complications: IL6
P-hsa04151-2	PI3K-Akt signaling pathway: EIF4E	7.98473904510457e-05	DOWN	-3.945263395536	0.000115335119540399	PI3K-Akt signaling pathway: EIF4E
P-hsa04024-31	cAMP signaling pathway: C00165	8.42860689936313e-05	UP	3.93228021694106	0.000121473875470105	cAMP signaling pathway: C00165
P-hsa04024-32	cAMP signaling pathway: C01245	8.42860689936313e-05	UP	3.93228021694106	0.000121473875470105	cAMP signaling pathway: C01245
P-hsa04022-46	cGMP-PKG signaling pathway: VASP	8.48570211902007e-05	DOWN	-3.9306573196167	0.000122159939901329	cGMP-PKG signaling pathway: VASP
P-hsa04152-68	AMPK signaling pathway: PPARGC1A**	8.92571354718229e-05	UP	3.91848558968395	0.000128350763522052	AMPK signaling pathway: PPARGC1A**
P-hsa04152-82	AMPK signaling pathway: HMGCR	9.61021434742408e-05	UP	3.90063371911591	0.000138039574387665	AMPK signaling pathway: HMGCR
P-hsa04390-13	Hippo signaling pathway: BIRC5	9.77255037451868e-05	UP	3.89657647580499	0.000140214853199616	Hippo signaling pathway: BIRC5
P-hsa04213-54	Longevity regulating pathway - multiple species: SOD2*	9.83820687692801e-05	UP	3.89495357848062	0.000140999690986708	Longevity regulating pathway - multiple species: SOD2*
P-hsa04920-1	Adipocytokine signaling pathway: C00195	0.000104481471314215	UP	3.88034750256132	0.000149574698088314	Adipocytokine signaling pathway: C00195
P-hsa04713-61	Circadian entrainment: FOS	0.000105180790810269	DOWN	-3.87872460523696	0.000150408530858685	Circadian entrainment: FOS
P-hsa03320-20	PPAR signaling pathway: SCP2	0.000112795261031982	DOWN	-3.8616841833311	0.000161118203050123	PPAR signaling pathway: SCP2
P-hsa04530-4 37 11	Tight junction: OCLN TJP3 TJP1	0.000114303374790537	DOWN	-3.85843838868237	0.000163091400615766	Tight junction: OCLN TJP3 TJP1
P-hsa04360-6	Axon guidance: MAPK1	0.000115830492447357	DOWN	-3.85519259403363	0.000165087313155867	Axon guidance: MAPK1
P-hsa03320-59	PPAR signaling pathway: NR1H3	0.000116601247387485	DOWN	-3.85356969670927	0.000166001997110281	PPAR signaling pathway: NR1H3
P-hsa04015-30	Rap1 signaling pathway: ITGAL	0.00011894263457405	DOWN	-3.84870100473617	0.000169148254913594	Rap1 signaling pathway: ITGAL
P-hsa04933-43	AGE-RAGE signaling pathway in diabetic complications: CASP3	0.000124168593381947	DOWN	-3.83815217212778	0.000176385187287601	AGE-RAGE signaling pathway in diabetic complications: CASP3
P-hsa04923-31	Regulation of lipolysis in adipocytes: PRKACA*	0.00012749135996063	DOWN	-3.83166058283031	0.000180905601178975	Regulation of lipolysis in adipocytes: PRKACA*
P-hsa04950-20	Maturity onset diabetes of the young: NKX6-1	0.000127912549472449	DOWN	-3.83084913416813	0.000181303360320531	Maturity onset diabetes of the young: NKX6-1
P-hsa04742-46	Taste transduction: P2RY1	0.000133070138962357	DOWN	-3.82111175022193	0.000188406236352644	Taste transduction: P2RY1
P-hsa04360-11	Axon guidance: NFATC2	0.000136616806314751	DOWN	-3.81462016092446	0.000193215197502291	Axon guidance: NFATC2
P-hsa04916-8	Melanogenesis: TYR*	0.000140713128396394	UP	3.80731712296481	0.000198790116625861	Melanogenesis: TYR*
P-hsa04660-26	T cell receptor signaling pathway: GRB2	0.000142104084170121	DOWN	-3.80488277697826	0.000200535039832177	T cell receptor signaling pathway: GRB2
P-hsa04510-26 4 5	Focal adhesion: ACTN4 ITGB1 ITGA11	0.000143978843280025	DOWN	-3.80163698232953	0.000202958128479072	Focal adhesion: ACTN4 ITGB1 ITGA11
P-hsa04810-82 83	Regulation of actin cytoskeleton: ACTB ARPC5	0.000145876876460217	DOWN	-3.79839118768079	0.000205408687094419	Regulation of actin cytoskeleton: ACTB ARPC5
P-hsa03460-7	Fanconi anemia pathway: FANCI	0.000146834704681956	UP	3.79676829035643	0.000206531437077243	Fanconi anemia pathway: FANCI
P-hsa04510-6 4 5	Focal adhesion: FLNA ITGB1 ITGA11	0.000149255247524039	DOWN	-3.79271104704551	0.000209706881619473	Focal adhesion: FLNA ITGB1 ITGA11
P-hsa04024-24	cAMP signaling pathway: PLN	0.000156234164114692	DOWN	-3.78135076577494	0.000219273030769475	cAMP signaling pathway: PLN
P-hsa04914-39	Progesterone-mediated oocyte maturation: PIK3R5	0.000156744233440272	DOWN	-3.78053931711276	0.000219510150639424	Progesterone-mediated oocyte maturation: PIK3R5
P-hsa04931-151	Insulin resistance: CPT1A	0.000156744233440272	DOWN	-3.78053931711276	0.000219510150639424	Insulin resistance: CPT1A
P-hsa04210-62	Apoptosis: TP53AIP1	0.000161931853033524	UP	3.77242483049092	0.000226528581363201	Apoptosis: TP53AIP1
P-hsa04810-26 80	Regulation of actin cytoskeleton: PFN3 ACTB	0.000188551594215072	UP	3.7342867433683	0.000263480892241909	Regulation of actin cytoskeleton: PFN3 ACTB
P-hsa04728-74	Dopaminergic synapse: GRIN2A	0.000190997595255752	UP	3.73104094871956	0.000266609441533788	Dopaminergic synapse: GRIN2A
P-hsa04931-13	Insulin resistance: AKT2	0.000197878760263801	UP	3.72211501343555	0.000275915454452342	Insulin resistance: AKT2
P-hsa04742-18	Taste transduction: PDE1A	0.00020897305059533	DOWN	-3.70832038617843	0.000291069606186353	Taste transduction: PDE1A
P-hsa04930-8	Type II diabetes mellitus: C00022	0.000209643517362487	UP	3.70750893751624	0.000291687791184347	Type II diabetes mellitus: C00022
P-hsa04152-77	AMPK signaling pathway: CCND1	0.000212345639748813	UP	3.70426314286751	0.000295128335158448	AMPK signaling pathway: CCND1
P-hsa04961-20	Endocrine and other factor-regulated calcium reabsorption: CALB1*	0.000218196536844439	DOWN	-3.69736582923895	0.000302933056007328	Endocrine and other factor-regulated calcium reabsorption: CALB1*
P-hsa04210-4	Apoptosis: DFFA	0.000226353842155929	UP	3.68803416962384	0.000313919606524441	Apoptosis: DFFA
P-hsa04917-34	Prolactin signaling pathway: ELF5	0.000226822828529742	DOWN	-3.65719912046087	0.000314231410460472	Prolactin signaling pathway: ELF5
P-hsa04020-8	Calcium signaling pathway: PDE1A	0.000229989002723954	DOWN	-3.68397692631292	0.000318275103769601	Calcium signaling pathway: PDE1A
P-hsa04360-20	Axon guidance: ROCK1	0.000241993113915832	DOWN	-3.67099374771799	0.000334527537711789	Axon guidance: ROCK1
P-hsa04924-31	Renin secretion: C02135	0.000255389877937429	DOWN	-3.65719912046087	0.000352668211271964	Renin secretion: C02135
P-hsa04666-41	Fc gamma R-mediated phagocytosis: MARCKS	0.000259460794509163	UP	3.65314187714995	0.000357905726187881	Fc gamma R-mediated phagocytosis: MARCKS
P-hsa04014-42	Ras signaling pathway: PLA2G4B	0.000270331239247658	DOWN	-3.64259304454157	0.000372501397121773	Ras signaling pathway: PLA2G4B
P-hsa04950-7	Maturity onset diabetes of the young: FOXA3	0.000293364822605323	UP	3.6214953793248	0.000403808049939091	Maturity onset diabetes of the young: FOXA3
P-hsa04710-7	Circadian rhythm: PER1	0.000298935229272302	DOWN	-3.6166266873517	0.000411035940249416	Circadian rhythm: PER1
P-hsa04933-59	AGE-RAGE signaling pathway in diabetic complications: SERPINE1	0.000348278607970583	DOWN	-3.57686570290471	0.000478372004757887	AGE-RAGE signaling pathway in diabetic complications: SERPINE1
P-hsa04152-30	AMPK signaling pathway: ACACA	0.000357024308151105	UP	3.57037411360724	0.000489861710650823	AMPK signaling pathway: ACACA
P-hsa04350-32	TGF-beta signaling pathway: RPS6KB1	0.000358131848087345	DOWN	-3.56956266494506	0.000490858028209172	TGF-beta signaling pathway: RPS6KB1
P-hsa04010-66	MAPK signaling pathway: TP53	0.000359242600316321	UP	3.56875121628287	0.000491856624050111	MAPK signaling pathway: TP53
P-hsa04919-32	Thyroid hormone signaling pathway: PLN	0.000361473776006695	DOWN	-3.56712831895851	0.000494385493858254	Thyroid hormone signaling pathway: PLN
P-hsa04810-21 82	Regulation of actin cytoskeleton: CFL1 ACTB	0.000388080873344577	UP	3.54846499972829	0.000530212403391158	Regulation of actin cytoskeleton: CFL1 ACTB
P-hsa04916-7	Melanogenesis: TYRP1	0.000392891001468225	UP	3.54521920507955	0.000536214972311353	Melanogenesis: TYRP1
P-hsa04110-43 83 84 85	Cell cycle: SMC1B SMC3 STAG1 RAD21	0.000407657742451154	DOWN	-3.53548182113335	0.000555779146752792	Cell cycle: SMC1B SMC3 STAG1 RAD21
P-hsa04360-40 139	Axon guidance: UNC5D DCC	0.000432102650024592	DOWN	-3.52006429655186	0.000588482656700158	Axon guidance: UNC5D DCC
P-hsa04350-34	TGF-beta signaling pathway: ROCK1	0.000485151334743847	DOWN	-3.48922924738889	0.000660031467035233	TGF-beta signaling pathway: ROCK1
P-hsa04728-68	Dopaminergic synapse: CACNA1C	0.000512345649504729	UP	3.47462317146959	0.000696292345208644	Dopaminergic synapse: CACNA1C
P-hsa04068-59	FoxO signaling pathway: S1PR1	0.000515453413668102	DOWN	-3.47300027414522	0.000699776944505113	FoxO signaling pathway: S1PR1
P-hsa04621-4 7 8	NOD-like receptor signaling pathway: IKBKG CHUK IKBKB	0.000555812195515257	DOWN	-3.45271405759064	0.000753772703506992	NOD-like receptor signaling pathway: IKBKG CHUK IKBKB
P-hsa04810-23	Regulation of actin cytoskeleton: GSN	0.000557486192646167	DOWN	-3.45190260892845	0.000755247084142754	Regulation of actin cytoskeleton: GSN
P-hsa04071-65	Sphingolipid signaling pathway: BAX*	0.000572764892762605	UP	3.4445995709688	0.00077512977600996	Sphingolipid signaling pathway: BAX*
P-hsa04724-26	Glutamatergic synapse: PRKACA	0.000590198061873715	UP	3.43648508434697	0.000797883304234739	Glutamatergic synapse: PRKACA
P-hsa04950-11	Maturity onset diabetes of the young: HNF4G	0.000591968281108507	UP	3.43567363568478	0.000799436702819149	Maturity onset diabetes of the young: HNF4G
P-hsa04971-37	Gastric acid secretion: KCNQ1	0.000630304007885875	DOWN	-3.41863321377893	0.000850315784223397	Gastric acid secretion: KCNQ1
P-hsa04115-9	p53 signaling pathway: RPRM	0.000664988519894026	UP	3.40402713785963	0.000896167774977604	p53 signaling pathway: RPRM
P-hsa04071-24	Sphingolipid signaling pathway: PTEN	0.000693183426939077	DOWN	-3.39266685658906	0.000933187312207733	Sphingolipid signaling pathway: PTEN
P-hsa04922-50	Glucagon signaling pathway: PCK1	0.000750722152668594	UP	3.37075774271011	0.00100959186048535	Glucagon signaling pathway: PCK1
P-hsa04610-52	Complement and coagulation cascades: CPB2	0.00075293606456844	UP	3.36994629404792	0.0010115122287052	Complement and coagulation cascades: CPB2
P-hsa04151-24	PI3K-Akt signaling pathway: MYC	0.000793837800818	DOWN	-3.35534021812862	0.00106534853978391	PI3K-Akt signaling pathway: MYC
P-hsa04211-42	Longevity regulating pathway - mammal: PPARGC1A	0.000879333576398406	UP	3.3269395149522	0.00117885657585911	Longevity regulating pathway - mammal: PPARGC1A
P-hsa04550-47	Signaling pathways regulating pluripotency of stem cells: CTNNB1*	0.000897425822452455	UP	3.32125937431692	0.00120185955618763	Signaling pathways regulating pluripotency of stem cells: CTNNB1*
P-hsa04610-7	Complement and coagulation cascades: C00290	0.000915862579115858	DOWN	-3.31557923368163	0.00122527561260094	Complement and coagulation cascades: C00290
P-hsa04724-52	Glutamatergic synapse: CACNA1A	0.000937362649768257	UP	3.30908764438416	0.001252736999223	Glutamatergic synapse: CACNA1A
P-hsa04110-48	Cell cycle: RB1*	0.000962108638950722	DOWN	-3.30178460642451	0.00128447491527965	Cell cycle: RB1*
P-hsa04722-33	Neurotrophin signaling pathway: BAD	0.000978940632843054	DOWN	-3.29691591445141	0.00130559232587462	Neurotrophin signaling pathway: BAD
P-hsa04520-1 13	Adherens junction: SMAD4 SMAD2	0.000996044954066209	DOWN	-3.29204722247831	0.00132702883631802	Adherens junction: SMAD4 SMAD2
P-hsa04114-59	Oocyte meiosis: REC8*	0.00100760109809613	UP	3.28880142782958	0.0013410368285933	Oocyte meiosis: REC8*
P-hsa04650-35	Natural killer cell mediated cytotoxicity: BID	0.00101050946286183	DOWN	-3.28798997916739	0.00134351826312312	Natural killer cell mediated cytotoxicity: BID
P-hsa04012-24	ErbB signaling pathway: CDKN1A	0.00101928124662674	DOWN	-3.28555563318084	0.00135378221301199	ErbB signaling pathway: CDKN1A
P-hsa04270-28	Vascular smooth muscle contraction: KCNMB2	0.00105811278436325	UP	3.27500680057246	0.00140390840564484	Vascular smooth muscle contraction: KCNMB2
P-hsa03320-38	PPAR signaling pathway: SORBS1	0.00111095846106101	DOWN	-3.26121217331534	0.00147250621975852	PPAR signaling pathway: SORBS1
P-hsa04360-31	Axon guidance: CDC42*	0.00112695956659732	DOWN	-3.25715493000442	0.00149217794466127	Axon guidance: CDC42*
P-hsa04114-56	Oocyte meiosis: REC8	0.00113991356763872	DOWN	-3.25390913535569	0.00150777878884999	Oocyte meiosis: REC8
P-hsa04919-102	Thyroid hormone signaling pathway: BMP4	0.001146442056491	DOWN	-3.25228623803132	0.00151485721427507	Thyroid hormone signaling pathway: BMP4
P-hsa04611-7	Platelet activation: ITPR1	0.00117625014461949	DOWN	-3.24498320007167	0.0015510593607841	Platelet activation: ITPR1
P-hsa04722-73 77	Neurotrophin signaling pathway: NGFRAP1 YWHAE	0.00117625014461949	DOWN	-3.24498320007167	0.0015510593607841	Neurotrophin signaling pathway: NGFRAP1 YWHAE
P-hsa03320-7	PPAR signaling pathway: AQP7	0.00119651833328238	DOWN	-3.24011450809857	0.00157617102859205	PPAR signaling pathway: AQP7
P-hsa04152-44	AMPK signaling pathway: SLC2A4	0.00121710874895619	DOWN	-3.23524581612547	0.00160165537822762	AMPK signaling pathway: SLC2A4
P-hsa04510-20 4 5	Focal adhesion: VASP ITGB1 ITGA11	0.00122404462491569	DOWN	-3.2336229188011	0.0016091373159004	Focal adhesion: VASP ITGB1 ITGA11
P-hsa04390-80	Hippo signaling pathway: BIRC2	0.0012380260186279	UP	3.23037712415237	0.00162585661834092	Hippo signaling pathway: BIRC2
P-hsa04064-96	NF-kappa B signaling pathway: BCL2A1	0.00128449046315029	DOWN	-3.21982829154398	0.00168515721312377	NF-kappa B signaling pathway: BCL2A1
P-hsa04390-77	Hippo signaling pathway: CCND1	0.00130278609245547	DOWN	-3.21577104823307	0.00170741924744419	Hippo signaling pathway: CCND1
P-hsa04917-71	Prolactin signaling pathway: CCND1*	0.00132132196103507	DOWN	-3.21171380492215	0.0017299505227387	Prolactin signaling pathway: CCND1*
P-hsa04610-57	Complement and coagulation cascades: PLAUR	0.00144178241860605	DOWN	-3.18655889639446	0.00188574590726217	Complement and coagulation cascades: PLAUR
P-hsa03320-60	PPAR signaling pathway: CYP27A1	0.00169005169271162	DOWN	-3.14030632265	0.00220821982590849	PPAR signaling pathway: CYP27A1
P-hsa04740-37	Olfactory transduction: CNGB1*	0.00171360705466628	DOWN	-3.13624907933909	0.00223672644965061	Olfactory transduction: CNGB1*
P-hsa04024-60	cAMP signaling pathway: PDE3A	0.00186651756273051	UP	3.1110941708114	0.00243384812891	cAMP signaling pathway: PDE3A
P-hsa04261-8 38	Adrenergic signaling in cardiomyocytes: ATP2A2 PLN	0.00190273681449076	DOWN	-3.10541403017611	0.00247856506098139	Adrenergic signaling in cardiomyocytes: ATP2A2 PLN
P-hsa04211-38	Longevity regulating pathway - mammal: BAX	0.00198253277876833	UP	3.09324230024336	0.0025798985705509	Longevity regulating pathway - mammal: BAX
P-hsa04726-39	Serotonergic synapse: CACNA1C	0.00208233781625021	DOWN	-3.07863622432406	0.00270703916112527	Serotonergic synapse: CACNA1C
P-hsa04976-37	Bile secretion: ABCB11	0.00210183791541036	DOWN	-3.06849311604677	0.00272963208590629	Bile secretion: ABCB11
P-hsa04910-20	Insulin signaling pathway: PKLR	0.00217490065665873	DOWN	-3.06565304572913	0.00282167050919334	Insulin signaling pathway: PKLR
P-hsa04670-18	Leukocyte transendothelial migration: CDH5	0.00225591755950013	DOWN	-3.05469848878965	0.00292383272817388	Leukocyte transendothelial migration: CDH5
P-hsa04620-39	Toll-like receptor signaling pathway: IL6	0.00227122141590194	DOWN	-3.05266986713419	0.00294070619946257	Toll-like receptor signaling pathway: IL6
P-hsa04071-68	Sphingolipid signaling pathway: NFKB1	0.00241004836728087	DOWN	-3.03481799656615	0.003117318842905	Sphingolipid signaling pathway: NFKB1
P-hsa04713-60	Circadian entrainment: PER1	0.00247568352623885	DOWN	-3.02670350994432	0.0031990007010737	Circadian entrainment: PER1
P-hsa04668-120	TNF signaling pathway: DNM1L	0.00248233619844816	UP	3.02589206128214	0.00320437982688344	TNF signaling pathway: DNM1L
P-hsa04932-96	Non-alcoholic fatty liver disease (NAFLD): IL6*	0.00250239247363174	DOWN	-3.02345771529559	0.0032270331799239	Non-alcoholic fatty liver disease (NAFLD): IL6*
P-hsa04724-65	Glutamatergic synapse: GRM3	0.00251247484772002	DOWN	-3.02224054230231	0.0032367919209366	Glutamatergic synapse: GRM3
P-hsa04022-57	cGMP-PKG signaling pathway: C00144	0.00251584556464645	DOWN	-3.02183481797122	0.00323789324169998	cGMP-PKG signaling pathway: C00144
P-hsa04722-34	Neurotrophin signaling pathway: GSK3B	0.00252936478446173	DOWN	-3.02021192064685	0.00325204043716509	Neurotrophin signaling pathway: GSK3B
P-hsa04066-59	HIF-1 signaling pathway: NOS2	0.00254976823876728	DOWN	-3.0177775746603	0.00327500171985378	HIF-1 signaling pathway: NOS2
P-hsa04012-40	ErbB signaling pathway: ELK1*	0.00270405388198595	DOWN	-2.99992570409226	0.00346970822145156	ErbB signaling pathway: ELK1*
P-hsa04924-30	Renin secretion: PDE3A	0.00307069889169119	UP	2.96097616830746	0.00393624449562406	Renin secretion: PDE3A
P-hsa03320-22	PPAR signaling pathway: ACADM	0.00320264344954256	DOWN	-2.94799298971252	0.00409721880672095	PPAR signaling pathway: ACADM
P-hsa04520-34	Adherens junction: RHOA	0.00320264344954256	DOWN	-2.94799298971252	0.00409721880672095	Adherens junction: RHOA
P-hsa04015-11	Rap1 signaling pathway: RAC1	0.00323642701557924	DOWN	-2.94474719506379	0.00413632727810376	Rap1 signaling pathway: RAC1
P-hsa04622-44	RIG-I-like receptor signaling pathway: MAPK8	0.00324492348861411	DOWN	-2.94393574640161	0.00414307195421266	RIG-I-like receptor signaling pathway: MAPK8
P-hsa03320-27	PPAR signaling pathway: CPT1C	0.00332231124057875	DOWN	-2.93663270844195	0.00423767548723969	PPAR signaling pathway: CPT1C
P-hsa04810-35 81 80	Regulation of actin cytoskeleton: MYL12B MYH9 ACTB	0.00337483297801254	DOWN	-2.93176401646885	0.0043004059828734	Regulation of actin cytoskeleton: MYL12B MYH9 ACTB
P-hsa04310-31	Wnt signaling pathway: MMP7	0.00398400315373099	DOWN	-2.87983130208911	0.00507162419273173	Wnt signaling pathway: MMP7
P-hsa04210-74	Apoptosis: BAX*	0.00406679081303314	UP	2.87333971279164	0.00517189701222693	Apoptosis: BAX*
P-hsa04921-41	Oxytocin signaling pathway: PTGS2	0.0041405075668967	DOWN	-2.86765957215636	0.00526044742210864	Oxytocin signaling pathway: PTGS2
P-hsa04360-19	Axon guidance: CDC42	0.00449317867338574	UP	2.84169321496649	0.00570288062391267	Axon guidance: CDC42
P-hsa03320-29	PPAR signaling pathway: OLR1	0.00457386406404604	DOWN	-2.8360130743312	0.0057995695078101	PPAR signaling pathway: OLR1
P-hsa04950-5	Maturity onset diabetes of the young: GCK	0.00472719819072039	DOWN	-2.82546424172282	0.00598809455852081	Maturity onset diabetes of the young: GCK
P-hsa04924-49	Renin secretion: PDE1A	0.00477530543818029	DOWN	-2.82221844707409	0.00604308564300692	Renin secretion: PDE1A
P-hsa04621-42	NOD-like receptor signaling pathway: MAPK8	0.00500992063821928	UP	2.8068009224926	0.00633376017818095	NOD-like receptor signaling pathway: MAPK8
P-hsa04068-47	FoxO signaling pathway: GADD45G	0.00511178682553591	DOWN	-2.80030933319513	0.00644987220045561	FoxO signaling pathway: GADD45G
P-hsa04068-54	FoxO signaling pathway: GADD45G*	0.00511178682553591	DOWN	-2.80030933319513	0.00644987220045561	FoxO signaling pathway: GADD45G*
P-hsa04723-7	Retrograde endocannabinoid signaling: ITPR1	0.00542871559170678	DOWN	-2.78083456530273	0.0068430528565393	Retrograde endocannabinoid signaling: ITPR1
P-hsa04726-45	Serotonergic synapse: TRPC1	0.00544229786746251	DOWN	-2.78002311664055	0.00685346120882999	Serotonergic synapse: TRPC1
P-hsa04610-23	Complement and coagulation cascades: BDKRB1	0.00556592573488897	DOWN	-2.77272007868089	0.00700229366647322	Complement and coagulation cascades: BDKRB1
P-hsa04925-34	Aldosterone synthesis and secretion: STAR	0.00569208211018159	DOWN	-2.76541704072124	0.00715401335527705	Aldosterone synthesis and secretion: STAR
P-hsa04213-71	Longevity regulating pathway - multiple species: SIRT1**	0.00572046473694784	DOWN	-2.76379414339688	0.00718267133312378	Longevity regulating pathway - multiple species: SIRT1**
P-hsa04922-51	Glucagon signaling pathway: G6PC	0.00583527596431778	UP	2.75730255409941	0.0073196882710302	Glucagon signaling pathway: G6PC
P-hsa04310-22	Wnt signaling pathway: ROCK2	0.00593743537606256	UP	2.75162241346412	0.00744058357253409	Wnt signaling pathway: ROCK2
P-hsa04670-14	Leukocyte transendothelial migration: SIPA1	0.006086173962782	DOWN	-2.74350792684229	0.00761955825885256	Leukocyte transendothelial migration: SIPA1
P-hsa04742-31	Taste transduction: C00076*	0.00625365567944776	DOWN	-2.73458199155827	0.0078216276573851	Taste transduction: C00076*
P-hsa04722-85	Neurotrophin signaling pathway: BAX	0.0066173188773726	UP	2.71591867232805	0.00826843630599858	Neurotrophin signaling pathway: BAX
P-hsa04921-34 35	Oxytocin signaling pathway: MYL9 ACTB	0.00693195905987821	UP	2.70050114774657	0.00865318264797601	Oxytocin signaling pathway: MYL9 ACTB
P-hsa04727-35	GABAergic synapse: PRKACA	0.0074742510648922	UP	2.67534623921888	0.0093210863570894	GABAergic synapse: PRKACA
P-hsa04910-39	Insulin signaling pathway: BAD	0.00751051031389282	DOWN	-2.67372334189451	0.00935723792253636	Insulin signaling pathway: BAD
P-hsa04722-84	Neurotrophin signaling pathway: NFKB1*	0.00767563641378992	DOWN	-2.66642030393486	0.00955371766397256	Neurotrophin signaling pathway: NFKB1*
P-hsa04015-17	Rap1 signaling pathway: ACTB	0.00842940522239442	DOWN	-2.63477380610971	0.0104817821461078	Rap1 signaling pathway: ACTB
P-hsa04723-40	Retrograde endocannabinoid signaling: GRIA1	0.00853068292068725	DOWN	-2.63071656279879	0.0105872602882589	Retrograde endocannabinoid signaling: GRIA1
P-hsa04724-4	Glutamatergic synapse: GRIA1	0.00853068292068725	DOWN	-2.63071656279879	0.0105872602882589	Glutamatergic synapse: GRIA1
P-hsa04910-17	Insulin signaling pathway: C00031	0.00911820233050285	DOWN	-2.60799600025765	0.0113055167623865	Insulin signaling pathway: C00031
P-hsa03320-39	PPAR signaling pathway: MMP1	0.0093366264313356	UP	2.59988151363582	0.011565195589152	PPAR signaling pathway: MMP1
P-hsa04010-118	MAPK signaling pathway: JUN	0.00935872355227972	DOWN	-2.59907006497363	0.0115814203959462	MAPK signaling pathway: JUN
P-hsa03320-36	PPAR signaling pathway: SLC27A4	0.00960488895569956	DOWN	-2.59014412968962	0.0118746321671329	PPAR signaling pathway: SLC27A4
P-hsa04390-58	Hippo signaling pathway: SMAD7	0.00971867849850672	UP	2.5860868863787	0.0120037804487314	Hippo signaling pathway: SMAD7
P-hsa04330-11	Notch signaling pathway: PTCRA	0.00978752754700192	DOWN	-2.58365254039215	0.0120772271840762	Notch signaling pathway: PTCRA
P-hsa04664-3 4 5	Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A	0.0103218483477448	DOWN	-2.54754307492498	0.0127243475321337	Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A
P-hsa04750-51	Inflammatory mediator regulation of TRP channels: TRPV4	0.0103783825386654	DOWN	-2.56336632383756	0.0127695777507289	Inflammatory mediator regulation of TRP channels: TRPV4
P-hsa04750-61	Inflammatory mediator regulation of TRP channels: TRPV4*	0.0103783825386654	DOWN	-2.56336632383756	0.0127695777507289	Inflammatory mediator regulation of TRP channels: TRPV4*
P-hsa04931-29	Insulin resistance: CPT1B	0.0105248271648845	UP	2.55849763186446	0.0129373949963767	Insulin resistance: CPT1B
P-hsa04390-5	Hippo signaling pathway: SAV1	0.010623475332766	DOWN	-2.55525183721573	0.0130461953752575	Hippo signaling pathway: SAV1
P-hsa04540-18 19	Gap junction: GJA1 GJA1***	0.0106980002135605	DOWN	-2.55281749122918	0.0131251918730718	Gap junction: GJA1 GJA1***
P-hsa04730-20	Long-term depression: C00025	0.0120934744330566	DOWN	-2.50981071213345	0.0148231443765179	Long-term depression: C00025
P-hsa04390-88	Hippo signaling pathway: ID1	0.0121491564232364	DOWN	-2.50818781480909	0.0148772258008613	Hippo signaling pathway: ID1
P-hsa04723-67	Retrograde endocannabinoid signaling: PRKACA	0.012402546751675	UP	2.50088477684943	0.015173077632515	Retrograde endocannabinoid signaling: PRKACA
P-hsa04071-1	Sphingolipid signaling pathway: MAPK1	0.0126028528559077	DOWN	-2.49520463621415	0.0154034868238871	Sphingolipid signaling pathway: MAPK1
P-hsa04022-60	cGMP-PKG signaling pathway: TRPC6*	0.0128352765531678	DOWN	-2.48871304691668	0.0156726763984127	cGMP-PKG signaling pathway: TRPC6*
P-hsa04012-3	ErbB signaling pathway: ELK1	0.01289397185331	UP	2.48709014959232	0.0157294234836114	ErbB signaling pathway: ELK1
P-hsa04726-41	Serotonergic synapse: HTR3C	0.0137686027567628	DOWN	-1.71702536918021	0.0167646090330688	Serotonergic synapse: HTR3C
P-hsa04742-57	Taste transduction: HTR3C	0.0137686027567628	DOWN	-1.71702536918021	0.0167646090330688	Taste transduction: HTR3C
P-hsa04912-33	GnRH signaling pathway: ELK1	0.0141188028373921	DOWN	-2.45463220310498	0.0171747629978484	GnRH signaling pathway: ELK1
P-hsa04068-53	FoxO signaling pathway: SOD2	0.0148686286162824	DOWN	-2.43596888387476	0.0180527594614674	FoxO signaling pathway: SOD2
P-hsa04520-43	Adherens junction: ACTB	0.0148686286162824	DOWN	-2.43596888387476	0.0180527594614674	Adherens junction: ACTB
P-hsa04340-50	Hedgehog signaling pathway: BCL2	0.0149020111906249	DOWN	-2.43515743521257	0.0180762378909842	Hedgehog signaling pathway: BCL2
P-hsa04210-107	Apoptosis: MCL1	0.0151375438090637	UP	2.42947729457729	0.0183446505482721	Apoptosis: MCL1
P-hsa04068-43	FoxO signaling pathway: CDKN1A	0.0151714575750507	DOWN	-2.42866584591511	0.0183684533387491	FoxO signaling pathway: CDKN1A
P-hsa04390-12	Hippo signaling pathway: CTGF	0.0152054382308829	DOWN	-2.42785439725292	0.0183922922961902	Hippo signaling pathway: CTGF
P-hsa04022-37 38	cGMP-PKG signaling pathway: ATP2A1 PLN	0.0155836715864142	DOWN	-2.4189284619689	0.0188320989030189	cGMP-PKG signaling pathway: ATP2A1 PLN
P-hsa04724-51	Glutamatergic synapse: ADRBK1	0.0175244345857732	DOWN	-2.37592168287318	0.0211575490730676	Glutamatergic synapse: ADRBK1
P-hsa04924-52	Renin secretion: KCNJ2	0.0203226297455088	UP	2.32074317384471	0.0245128626827271	Renin secretion: KCNJ2
P-hsa04152-54	AMPK signaling pathway: SLC2A4*	0.0218158057146302	UP	2.29396536799265	0.026289271493192	AMPK signaling pathway: SLC2A4*
P-hsa04976-38	Bile secretion: ABCC2	0.0227664867486202	UP	2.27773639474898	0.0274092314737832	Bile secretion: ABCC2
P-hsa04931-77	Insulin resistance: PPP2R4**	0.0231567177212931	DOWN	-2.27124480545151	0.0278529866423404	Insulin resistance: PPP2R4**
P-hsa04152-52	AMPK signaling pathway: PCK1	0.0244138716735778	UP	2.25095858889693	0.0293376777253918	AMPK signaling pathway: PCK1
P-hsa04014-37	Ras signaling pathway: FASLG	0.0251433882180998	DOWN	-2.23959830762636	0.0301861386536328	Ras signaling pathway: FASLG
P-hsa04066-62	HIF-1 signaling pathway: NPPA	0.0263278933208205	DOWN	-2.22174643705832	0.0315787499570326	HIF-1 signaling pathway: NPPA
P-hsa04390-18	Hippo signaling pathway: MOB1A	0.026770422171316	DOWN	-2.21525484776086	0.0320796399762419	Hippo signaling pathway: MOB1A
P-hsa04530-4 45	Tight junction: OCLN TJP2	0.0274462544994262	UP	2.20551746381465	0.0328589112007084	Tight junction: OCLN TJP2
P-hsa04010-119	MAPK signaling pathway: NFATC3	0.0275032325188169	UP	2.20470601515247	0.0328965243975069	MAPK signaling pathway: NFATC3
P-hsa04066-30	HIF-1 signaling pathway: PDK1	0.0276174947218896	UP	2.2030831178281	0.0330025215478848	HIF-1 signaling pathway: PDK1
P-hsa04550-17	Signaling pathways regulating pluripotency of stem cells: AKT3	0.0279049429618538	DOWN	-2.19902587451719	0.0333150849646622	Signaling pathways regulating pluripotency of stem cells: AKT3
P-hsa04152-56	AMPK signaling pathway: FASN	0.0302368631901565	DOWN	-2.16737937669203	0.0360656560942831	AMPK signaling pathway: FASN
P-hsa03320-21	PPAR signaling pathway: ACAA1	0.0306100867790353	DOWN	-2.16251068471893	0.0364770200783504	PPAR signaling pathway: ACAA1
P-hsa04520-69	Adherens junction: IQGAP1**	0.0310505083611059	DOWN	-2.15683054408365	0.0369676265131761	Adherens junction: IQGAP1**
P-hsa04728-64	Dopaminergic synapse: SCN1A	0.0360487061985779	UP	2.09678334308207	0.042878636670582	Dopaminergic synapse: SCN1A
P-hsa04670-15	Leukocyte transendothelial migration: PECAM1	0.0384898356098415	DOWN	-2.07000553723002	0.0457399985501994	Leukocyte transendothelial migration: PECAM1
P-hsa04724-5 71	Glutamatergic synapse: GRIN3A DLG4	0.0398012979962921	DOWN	-2.0562109099729	0.0472548621044539	Glutamatergic synapse: GRIN3A DLG4
P-hsa04390-89	Hippo signaling pathway: ID2	0.0425382146549319	DOWN	-2.02862165545866	0.0504577716690298	Hippo signaling pathway: ID2
P-hsa04152-24	AMPK signaling pathway: SIRT1	0.0426210639087512	DOWN	-2.02781020679648	0.0505094928642383	AMPK signaling pathway: SIRT1
P-hsa04152-53	AMPK signaling pathway: G6PC	0.0440505109208534	DOWN	-2.01401557953936	0.0521554807314979	AMPK signaling pathway: G6PC
P-hsa04062-59	Chemokine signaling pathway: FOXO3	0.0444785610195668	UP	2.00995833622844	0.0526138860589913	Chemokine signaling pathway: FOXO3
P-hsa04923-26 27	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5	0.0455202196262834	UP	2.00022095228224	0.0537966231946986	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5
P-hsa04210-106	Apoptosis: TUBA1B	0.0486764810228155	UP	1.97182024910582	0.0574739734645537	Apoptosis: TUBA1B
P-hsa04550-53 64	Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4	0.0493293007956489	DOWN	-1.96614010847053	0.0581913933308892	Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4
P-hsa04920-31	Adipocytokine signaling pathway: AGRP	0.0508490829192674	UP	1.9531569298756	0.059929276297708	Adipocytokine signaling pathway: AGRP
P-hsa04621-44	NOD-like receptor signaling pathway: MAPK14	0.0550260646836668	UP	1.91907608606389	0.0647928135845189	NOD-like receptor signaling pathway: MAPK14
P-hsa04068-46	FoxO signaling pathway: PLK4	0.0551289032285951	UP	1.91826463740171	0.0648545689718481	FoxO signaling pathway: PLK4
P-hsa04115-11 12	p53 signaling pathway: CDK2 CCNE1	0.0567962261927678	UP	1.90528145880677	0.0667550165388969	p53 signaling pathway: CDK2 CCNE1
P-hsa04068-68	FoxO signaling pathway: ATG12	0.0570075616753931	DOWN	-1.90365856148241	0.0669422736096997	FoxO signaling pathway: ATG12
P-hsa04925-18	Aldosterone synthesis and secretion: PDE2A	0.0574321954390972	DOWN	-1.90041276683367	0.0673794307476008	Aldosterone synthesis and secretion: PDE2A
P-hsa04068-40	FoxO signaling pathway: CCND1	0.0581816323600983	DOWN	-1.89473262619839	0.0681965035040496	FoxO signaling pathway: CCND1
P-hsa04390-95	Hippo signaling pathway: AFP	0.0617118327244953	DOWN	-1.86876626900852	0.0722685429630805	Hippo signaling pathway: AFP
P-hsa04152-94	AMPK signaling pathway: MLYCD	0.0654175114039073	DOWN	-1.84279991181865	0.0765384883425715	AMPK signaling pathway: MLYCD
P-hsa04970-21	Salivary secretion: ITPR1	0.0657741333509761	DOWN	-1.8403655658321	0.0768858398026396	Salivary secretion: ITPR1
P-hsa04960-3	Aldosterone-regulated sodium reabsorption: SCNN1A	0.0678253793884192	DOWN	-1.82657093857498	0.0792116726614297	Aldosterone-regulated sodium reabsorption: SCNN1A
P-hsa04933-21	AGE-RAGE signaling pathway in diabetic complications: SMAD4	0.0804179530606797	DOWN	-1.74867186700536	0.0938330966356254	AGE-RAGE signaling pathway in diabetic complications: SMAD4
P-hsa04919-21 53	Thyroid hormone signaling pathway: THRA C02465	0.0812642133054114	DOWN	-1.74380317503226	0.0947346399674498	Thyroid hormone signaling pathway: THRA C02465
P-hsa04390-14	Hippo signaling pathway: AREG	0.0814059568989737	DOWN	-1.74299172637008	0.0948139968588047	Hippo signaling pathway: AREG
P-hsa04024-115	cAMP signaling pathway: F2R	0.0856045413640185	DOWN	-1.71945971516676	0.0996139644986363	cAMP signaling pathway: F2R
P-hsa04350-21	TGF-beta signaling pathway: CDKN2B	0.0860486907112318	UP	1.71702536918021	0.100040347737448	TGF-beta signaling pathway: CDKN2B
P-hsa04976-34	Bile secretion: SLCO1B1	0.0905489065581729	UP	1.67767010906431	0.105177294892029	Bile secretion: SLCO1B1
P-hsa04520-4	Adherens junction: CTNND1	0.0946864217193478	UP	1.67158424409793	0.109884061995312	Adherens junction: CTNND1
P-hsa04390-78	Hippo signaling pathway: SOX2	0.102289955503639	DOWN	-1.6342576056375	0.118601056516382	Hippo signaling pathway: SOX2
P-hsa04976-41	Bile secretion: CYP7A1	0.102747510502315	DOWN	-1.63020036232658	0.119024343849216	Bile secretion: CYP7A1
P-hsa04910-26	Insulin signaling pathway: RPS6	0.1060943108738	UP	1.61640573506946	0.122790807639012	Insulin signaling pathway: RPS6
P-hsa04015-67	Rap1 signaling pathway: AKT3	0.106974394524232	UP	1.61234849175854	0.123698154315083	Rap1 signaling pathway: AKT3
P-hsa04610-11	Complement and coagulation cascades: F2R	0.107505215055477	UP	1.60991414577199	0.124200369637701	Complement and coagulation cascades: F2R
P-hsa04022-59	cGMP-PKG signaling pathway: NPPB	0.109649386128037	UP	1.60017676182579	0.126563910266173	cGMP-PKG signaling pathway: NPPB
P-hsa04750-62	Inflammatory mediator regulation of TRP channels: TRPM8*	0.113866240537057	DOWN	-1.5802962696023	0.131313487070961	Inflammatory mediator regulation of TRP channels: TRPM8*
P-hsa04550-60	Signaling pathways regulating pluripotency of stem cells: MAPK14	0.121076084340042	DOWN	-1.5506783934326	0.139503062261087	Signaling pathways regulating pluripotency of stem cells: MAPK14
P-hsa04976-36	Bile secretion: SLC10A1	0.121927622981004	DOWN	-1.54662115012168	0.140358542733947	Bile secretion: SLC10A1
P-hsa04630-34	Jak-STAT signaling pathway: AOX1	0.12442117918726	DOWN	-1.53688376617548	0.143101034507599	Jak-STAT signaling pathway: AOX1
P-hsa04152-60	AMPK signaling pathway: EEF2	0.124620172401416	UP	1.5360723175133	0.143201930250556	AMPK signaling pathway: EEF2
P-hsa03320-28	PPAR signaling pathway: ACSL1	0.129061112545839	DOWN	-1.51822044694526	0.148172749194018	PPAR signaling pathway: ACSL1
P-hsa04211-52	Longevity regulating pathway - mammal: PPARG	0.134466895965987	DOWN	-1.49712278172849	0.154241439490396	Longevity regulating pathway - mammal: PPARG
P-hsa04340-14	Hedgehog signaling pathway: PTCH1	0.135313871152998	UP	1.49387698707976	0.155074757056018	Hedgehog signaling pathway: PTCH1
P-hsa04340-26	Hedgehog signaling pathway: PTCH1**	0.138959563801261	DOWN	-1.48008235982264	0.159111173142547	Hedgehog signaling pathway: PTCH1**
P-hsa04740-42	Olfactory transduction: PDE2A	0.143123164758748	DOWN	-1.46466483524115	0.163732900484007	Olfactory transduction: PDE2A
P-hsa04750-60	Inflammatory mediator regulation of TRP channels: TRPV3	0.147598432529352	UP	1.44843586199748	0.168702648903443	Inflammatory mediator regulation of TRP channels: TRPV3
P-hsa04919-43	Thyroid hormone signaling pathway: TBC1D4	0.14783568381411	DOWN	-1.4476244133353	0.168823890921703	Thyroid hormone signaling pathway: TBC1D4
P-hsa04370-37	VEGF signaling pathway: CASP9	0.149891264518583	DOWN	-1.44032137537565	0.171019554464021	VEGF signaling pathway: CASP9
P-hsa04742-54	Taste transduction: P2RX2*	0.150518802035081	DOWN	-1.43342406174709	0.17143159134438	Taste transduction: P2RX2*
P-hsa04742-40	Taste transduction: P2RX2	0.150518802035081	DOWN	-1.43342406174709	0.17143159134438	Taste transduction: P2RX2
P-hsa04152-41	AMPK signaling pathway: FBP1	0.151968575170265	UP	1.433018337416	0.17292975795237	AMPK signaling pathway: FBP1
P-hsa04722-37	Neurotrophin signaling pathway: NFKB1	0.155007736179059	UP	1.42246950480761	0.176232293694743	Neurotrophin signaling pathway: NFKB1
P-hsa04066-48	HIF-1 signaling pathway: PFKFB3	0.158092831228426	DOWN	-1.41192067219923	0.179581177220639	HIF-1 signaling pathway: PFKFB3
P-hsa04211-50	Longevity regulating pathway - mammal: PPARGC1A*	0.158811336035113	UP	1.40948632621268	0.180238262325565	Longevity regulating pathway - mammal: PPARGC1A*
P-hsa04014-45	Ras signaling pathway: RAB5A	0.162685159663604	UP	1.39650314761774	0.184472070913708	Ras signaling pathway: RAB5A
P-hsa04068-55	FoxO signaling pathway: ATM	0.163664662314161	UP	1.39325735296901	0.185419384153456	FoxO signaling pathway: ATM
P-hsa04360-114	Axon guidance: RAF1	0.168378074906262	UP	1.37783982838752	0.190591541252735	Axon guidance: RAF1
P-hsa04950-31	Maturity onset diabetes of the young: NKX6-1*	0.169383229149133	DOWN	-1.37459403373879	0.191560822420856	Maturity onset diabetes of the young: NKX6-1*
P-hsa03320-58	PPAR signaling pathway: CYP8B1	0.174219233742881	DOWN	-1.3591765091573	0.196857027065047	PPAR signaling pathway: CYP8B1
P-hsa04360-89	Axon guidance: CAMK2A	0.178895130945411	UP	1.344570433238	0.201963187304162	Axon guidance: CAMK2A
P-hsa04068-45	FoxO signaling pathway: RBL2	0.185004908816251	DOWN	-1.32590711400778	0.208495024208857	FoxO signaling pathway: RBL2
P-hsa04910-24	Insulin signaling pathway: ACACA	0.185004908816251	DOWN	-1.32590711400778	0.208495024208857	Insulin signaling pathway: ACACA
P-hsa04925-5	Aldosterone synthesis and secretion: KCNK3	0.187165836076781	DOWN	-1.31941552471031	0.210745783928974	Aldosterone synthesis and secretion: KCNK3
P-hsa03460-25 40	Fanconi anemia pathway: MLH1 PMS2	0.189071888377326	UP	1.31373538407503	0.212705874424492	Fanconi anemia pathway: MLH1 PMS2
P-hsa04210-75	Apoptosis: BAK1*	0.190717005214712	UP	1.30886669210193	0.214369245162737	Apoptosis: BAK1*
P-hsa04919-11	Thyroid hormone signaling pathway: CTNNB1	0.193482243940688	UP	1.30075220548009	0.217287650917684	Thyroid hormone signaling pathway: CTNNB1
P-hsa04390-79	Hippo signaling pathway: SNAI2	0.195996034179907	DOWN	-1.29344916752044	0.219918828238483	Hippo signaling pathway: SNAI2
P-hsa04022-9	cGMP-PKG signaling pathway: ITPR1	0.197967688923039	DOWN	-1.28776902688516	0.221937644289156	cGMP-PKG signaling pathway: ITPR1
P-hsa04550-25	Signaling pathways regulating pluripotency of stem cells: MAPK1	0.200523941978212	DOWN	-1.28046598892551	0.224607757463846	Signaling pathways regulating pluripotency of stem cells: MAPK1
P-hsa04922-67	Glucagon signaling pathway: FBP1	0.206290587309929	UP	1.26423701568184	0.23086607466772	Glucagon signaling pathway: FBP1
P-hsa04211-51	Longevity regulating pathway - mammal: NFKB1	0.208924508928342	DOWN	-1.25693397772218	0.233610636829519	Longevity regulating pathway - mammal: NFKB1
P-hsa03320-41	PPAR signaling pathway: ANGPTL4	0.20921866423485	UP	1.25612252906	0.233736476449871	PPAR signaling pathway: ANGPTL4
P-hsa04910-57	Insulin signaling pathway: GCK	0.213667041700812	DOWN	-1.24395079912725	0.238499117666041	Insulin signaling pathway: GCK
P-hsa04919-29	Thyroid hormone signaling pathway: HIF1A	0.217274572901533	DOWN	-1.23421341518105	0.242315749847723	Thyroid hormone signaling pathway: HIF1A
P-hsa04340-32	Hedgehog signaling pathway: PTCH1***	0.220314148522505	UP	1.22609892855921	0.245492908353649	Hedgehog signaling pathway: PTCH1***
P-hsa04115-22	p53 signaling pathway: STEAP3	0.221538480061024	DOWN	-1.22285313391048	0.246643619237489	p53 signaling pathway: STEAP3
P-hsa04530-4 53	Tight junction: OCLN OCLN	0.222459922705848	DOWN	-1.22041878792393	0.247455419639089	Tight junction: OCLN OCLN
P-hsa04510-23 4 5	Focal adhesion: TLN1 ITGB1 ITGA11	0.226484544983465	DOWN	-1.20986995531554	0.251714688595613	Focal adhesion: TLN1 ITGB1 ITGA11
P-hsa04740-39	Olfactory transduction: PRKG1*	0.227420635048415	DOWN	-1.20743560932899	0.252536977832019	Olfactory transduction: PRKG1*
P-hsa04724-33 70 69	Glutamatergic synapse: ITPR1 HOMER3 HOMER3	0.232142454262184	UP	1.19526387939624	0.257558050547785	Glutamatergic synapse: ITPR1 HOMER3 HOMER3
P-hsa04610-58	Complement and coagulation cascades: F2RL2	0.233413276150691	DOWN	-1.19201808474751	0.258744949531386	Complement and coagulation cascades: F2RL2
P-hsa04970-12	Salivary secretion: BEST2	0.233798588822302	UP	1.18917801442987	0.258949039427111	Salivary secretion: BEST2
P-hsa03320-40	PPAR signaling pathway: FABP4	0.237255312349786	DOWN	-1.18228070080131	0.262551665515197	PPAR signaling pathway: FABP4
P-hsa04390-59	Hippo signaling pathway: SERPINE1	0.240166015465758	UP	1.17497766284166	0.265544383079408	Hippo signaling pathway: SERPINE1
P-hsa04621-43	NOD-like receptor signaling pathway: MAPK1	0.241467706597888	UP	1.17173186819292	0.26675445355492	NOD-like receptor signaling pathway: MAPK1
P-hsa03320-10	PPAR signaling pathway: PLIN1	0.242447228548751	DOWN	-1.16929752220637	0.267606846605697	PPAR signaling pathway: PLIN1
P-hsa04068-88	FoxO signaling pathway: FBXO32	0.245072938611603	UP	1.1628059329089	0.270041842459875	FoxO signaling pathway: FBXO32
P-hsa04920-9	Adipocytokine signaling pathway: G6PC	0.245072938611603	DOWN	-1.1628059329089	0.270041842459875	Adipocytokine signaling pathway: G6PC
P-hsa04068-67	FoxO signaling pathway: GABARAP	0.252396303325415	DOWN	-1.14495406234087	0.277873432318058	FoxO signaling pathway: GABARAP
P-hsa04390-60	Hippo signaling pathway: CTGF*	0.252732769834772	DOWN	-1.14414261367868	0.278006046818249	Hippo signaling pathway: CTGF*
P-hsa04720-4 15	Long-term potentiation: CREBBP ATF4	0.257817294672769	DOWN	-1.13197088374593	0.283356838807731	Long-term potentiation: CREBBP ATF4
P-hsa04720-32	Long-term potentiation: ITPR1	0.260214191338066	DOWN	-1.12629074311065	0.285747153798712	Long-term potentiation: ITPR1
P-hsa04520-17	Adherens junction: SNAI1	0.265054138027077	UP	1.11493046184008	0.290566163237519	Adherens junction: SNAI1
P-hsa04540-16 17	Gap junction: GJA1 GJA1**	0.265054138027077	UP	1.11493046184008	0.290566163237519	Gap junction: GJA1 GJA1**
P-hsa04919-91	Thyroid hormone signaling pathway: PFKP	0.26575058964867	UP	1.11330756451571	0.291081709683267	Thyroid hormone signaling pathway: PFKP
P-hsa03320-8	PPAR signaling pathway: GK	0.269603589993603	DOWN	-1.10438162923169	0.295050867620551	PPAR signaling pathway: GK
P-hsa04630-33	Jak-STAT signaling pathway: RAF1	0.271367562977727	UP	1.10032438592078	0.296729017461626	Jak-STAT signaling pathway: RAF1
P-hsa04931-40	Insulin resistance: PRKCZ	0.283572102852621	UP	1.07273513140654	0.309810947683636	Insulin resistance: PRKCZ
P-hsa04920-10	Adipocytokine signaling pathway: PCK1	0.286863997136504	UP	1.06543209344689	0.31314161519481	Adipocytokine signaling pathway: PCK1
P-hsa04710-11	Circadian rhythm: CRY1	0.288335310486224	UP	1.06218629879815	0.314480969996416	Circadian rhythm: CRY1
P-hsa04022-43	cGMP-PKG signaling pathway: MAPK1	0.29203582025937	DOWN	-1.05407181217632	0.318247333339381	cGMP-PKG signaling pathway: MAPK1
P-hsa04620-86	Toll-like receptor signaling pathway: IL12A	0.30028882351649	DOWN	-1.03621994160828	0.326964226620747	Toll-like receptor signaling pathway: IL12A
P-hsa03320-56	PPAR signaling pathway: FADS2	0.307925206137456	UP	1.01999096836461	0.33499555392976	PPAR signaling pathway: FADS2
P-hsa04310-14	Wnt signaling pathway: PRKCA	0.311791170293624	DOWN	-1.01187648174278	0.338914895412072	Wnt signaling pathway: PRKCA
P-hsa03320-61	PPAR signaling pathway: APOA1	0.320803804401894	UP	0.993213162512559	0.348417296426361	PPAR signaling pathway: APOA1
P-hsa04550-69	Signaling pathways regulating pluripotency of stem cells: ID1	0.322388425694795	DOWN	-0.989967367863825	0.349843089265769	Signaling pathways regulating pluripotency of stem cells: ID1
P-hsa04390-94	Hippo signaling pathway: GLI2	0.328777884757641	UP	0.97698418926889	0.356476105882969	Hippo signaling pathway: GLI2
P-hsa04115-52 53	p53 signaling pathway: CDK4 CCND1	0.333623484281547	UP	0.967246805322688	0.361425441305009	p53 signaling pathway: CDK4 CCND1
P-hsa04950-1	Maturity onset diabetes of the young: HNF1B	0.336549461121584	UP	0.957509421376487	0.36428860930486	Maturity onset diabetes of the young: HNF1B
P-hsa04810-29	Regulation of actin cytoskeleton: ACTN4	0.338105548492304	UP	0.95832087003867	0.365358388673043	Regulation of actin cytoskeleton: ACTN4
P-hsa04913-45	Ovarian steroidogenesis: ACOT2	0.338105548492304	UP	0.95832087003867	0.365358388673043	Ovarian steroidogenesis: ACOT2
P-hsa04920-2	Adipocytokine signaling pathway: C00638	0.339744933837199	DOWN	-0.955075075389937	0.366821921013821	Adipocytokine signaling pathway: C00638
P-hsa04110-96 97	Cell cycle: TFDP1 E2F4	0.350524876394536	DOWN	-0.933977410173166	0.378143768583209	Cell cycle: TFDP1 E2F4
P-hsa04950-30	Maturity onset diabetes of the young: PAX6*	0.363658064976343	DOWN	-0.908822501645479	0.391983190640329	Maturity onset diabetes of the young: PAX6*
P-hsa04550-36	Signaling pathways regulating pluripotency of stem cells: AKT3*	0.364945151524561	DOWN	-0.906388155658929	0.393041347290469	Signaling pathways regulating pluripotency of stem cells: AKT3*
P-hsa04310-34	Wnt signaling pathway: FOSL1	0.375344026440367	DOWN	-0.886913387766526	0.403902811060829	Wnt signaling pathway: FOSL1
P-hsa04014-26	Ras signaling pathway: PRKCA	0.380170748639681	UP	0.877987452482507	0.408755015454695	Ras signaling pathway: PRKCA
P-hsa03320-9	PPAR signaling pathway: PCK1	0.389043788444847	DOWN	-0.861758479238838	0.417946039840165	PPAR signaling pathway: PCK1
P-hsa04950-15	Maturity onset diabetes of the young: IAPP	0.398494896177403	DOWN	-0.844718057332985	0.427742228006937	Maturity onset diabetes of the young: IAPP
P-hsa04530-6 11 45	Tight junction: CLDN24 TJP1 TJP2	0.406704882904762	DOWN	-0.830111981413683	0.436190986915357	Tight junction: CLDN24 TJP1 TJP2
P-hsa03320-33	PPAR signaling pathway: CYP7A1	0.415944465203672	DOWN	-0.813883008170014	0.445728998099188	PPAR signaling pathway: CYP7A1
P-hsa04650-40	Natural killer cell mediated cytotoxicity: TNFRSF10D	0.418273578656793	UP	0.809825764859097	0.447851993120876	Natural killer cell mediated cytotoxicity: TNFRSF10D
P-hsa04068-49	FoxO signaling pathway: BCL2L11	0.432884554504959	DOWN	-0.784670856331409	0.463110907437974	FoxO signaling pathway: BCL2L11
P-hsa03320-25	PPAR signaling pathway: EHHADH	0.435268519718925	UP	0.780613613020492	0.465274572158021	PPAR signaling pathway: EHHADH
P-hsa04550-101	Signaling pathways regulating pluripotency of stem cells: ESRRB	0.436702527853024	UP	0.778179267033941	0.466420044271238	Signaling pathways regulating pluripotency of stem cells: ESRRB
P-hsa04310-20	Wnt signaling pathway: MAPK8	0.439098579027919	DOWN	-0.774122023723024	0.468590274634272	Wnt signaling pathway: MAPK8
P-hsa04530-13 45 20	Tight junction: EPB41 TJP2 ACTB	0.440059109735084	DOWN	-0.772499126398657	0.469226242111892	Tight junction: EPB41 TJP2 ACTB
P-hsa03320-53	PPAR signaling pathway: ADIPOQ	0.442465703183609	DOWN	-0.76844188308774	0.471401788077239	PPAR signaling pathway: ADIPOQ
P-hsa04910-12	Insulin signaling pathway: FASN	0.444879807527008	DOWN	-0.764384639776823	0.473581730593267	Insulin signaling pathway: FASN
P-hsa04152-87	AMPK signaling pathway: CD36	0.480970084888431	DOWN	-0.70514888743743	0.511577272108604	AMPK signaling pathway: CD36
P-hsa04068-60	FoxO signaling pathway: RAG1	0.482992676318827	UP	0.701903092788696	0.513304355427193	FoxO signaling pathway: RAG1
P-hsa04919-87	Thyroid hormone signaling pathway: BAD	0.484512646135511	UP	0.699468746802146	0.514494864336966	Thyroid hormone signaling pathway: BAD
P-hsa04340-31	Hedgehog signaling pathway: GLI1***	0.485527397868587	UP	0.697845849477779	0.515147371027924	Hedgehog signaling pathway: GLI1***
P-hsa04012-21	ErbB signaling pathway: GSK3B	0.505024425943353	UP	0.667010800314807	0.535392451556091	ErbB signaling pathway: GSK3B
P-hsa04210-50	Apoptosis: SPTA1	0.506061891768365	UP	0.66538790299044	0.536050744613898	Apoptosis: SPTA1
P-hsa03320-47	PPAR signaling pathway: PLTP	0.514401817460753	DOWN	-0.652404724395505	0.544436791999991	PPAR signaling pathway: PLTP
P-hsa04390-90	Hippo signaling pathway: BBC3	0.514925425221153	UP	0.651593275733321	0.544543157156634	Hippo signaling pathway: BBC3
P-hsa04068-66	FoxO signaling pathway: BNIP3	0.515973470793681	DOWN	-0.649970378408954	0.545203495001205	FoxO signaling pathway: BNIP3
P-hsa04068-44	FoxO signaling pathway: CDKN1B	0.52281263943642	DOWN	-0.639421545800569	0.551976921209739	FoxO signaling pathway: CDKN1B
P-hsa04550-22	Signaling pathways regulating pluripotency of stem cells: SMAD2	0.527574573226644	UP	0.632118507840918	0.556547930936632	Signaling pathways regulating pluripotency of stem cells: SMAD2
P-hsa04722-70	Neurotrophin signaling pathway: ZNF274	0.530761438265544	UP	0.627249815867817	0.559451245739357	Neurotrophin signaling pathway: ZNF274
P-hsa04015-14	Rap1 signaling pathway: MAPK14	0.536629290027144	DOWN	-0.618323880583799	0.5651734011988	Rap1 signaling pathway: MAPK14
P-hsa04920-28	Adipocytokine signaling pathway: SLC2A1	0.538235257841968	DOWN	-0.615889534597249	0.566401289323477	Adipocytokine signaling pathway: SLC2A1
P-hsa04931-144	Insulin resistance: C00533*	0.54575243719112	UP	0.60452925332668	0.573842636164193	Insulin resistance: C00533*
P-hsa04550-62 63	Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4	0.54684094284258	UP	0.602906356002313	0.57451779056196	Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4
P-hsa04024-109	cAMP signaling pathway: BDNF	0.563158010883577	UP	0.578562896136809	0.591178107673054	cAMP signaling pathway: BDNF
P-hsa04970-32	Salivary secretion: RYR3	0.568098524053918	UP	0.571259858177158	0.59587840298076	Salivary secretion: RYR3
P-hsa03320-63	PPAR signaling pathway: DBI	0.573059676974146	UP	0.563956820217507	0.60059267448349	PPAR signaling pathway: DBI
P-hsa04068-72	FoxO signaling pathway: SMAD2	0.574164940333413	DOWN	-0.56233392289314	0.601261414327993	FoxO signaling pathway: SMAD2
P-hsa04915-58	Estrogen signaling pathway: CREB3***	0.575271212099076	DOWN	-0.560711025568773	0.601930121928057	Estrogen signaling pathway: CREB3***
P-hsa04261-62	Adrenergic signaling in cardiomyocytes: BCL2	0.5780412901729	DOWN	-0.556653782257856	0.604337238385477	Adrenergic signaling in cardiomyocytes: BCL2
P-hsa04742-37	Taste transduction: P2RY4	0.582368307530902	DOWN	-0.546916398311654	0.608366892688531	Taste transduction: P2RY4
P-hsa04012-25	ErbB signaling pathway: CDKN1B	0.592545866129074	UP	0.535556117041086	0.618496779974143	ErbB signaling pathway: CDKN1B
P-hsa04012-31	ErbB signaling pathway: BAD	0.593107052925003	UP	0.534744668378902	0.61858085665679	ErbB signaling pathway: BAD
P-hsa04725-64	Cholinergic synapse: KCNJ3	0.604947785546617	UP	0.51770424647305	0.630419271253842	Cholinergic synapse: KCNJ3
P-hsa04725-25	Cholinergic synapse: CACNA1A	0.607215126716801	DOWN	-0.514458451824316	0.632270119809484	Cholinergic synapse: CACNA1A
P-hsa04973-5	Carbohydrate digestion and absorption: SLC2A5	0.60891811827418	DOWN	-0.512024105837765	0.633530815051633	Carbohydrate digestion and absorption: SLC2A5
P-hsa04725-54	Cholinergic synapse: CHRM1*	0.617464760926171	DOWN	-0.499852375905013	0.641903996213232	Cholinergic synapse: CHRM1*
P-hsa04015-95	Rap1 signaling pathway: THBS1	0.622617822328112	UP	0.492549337945362	0.646738609633801	Rap1 signaling pathway: THBS1
P-hsa04270-24	Vascular smooth muscle contraction: ACTA2	0.638187488310497	DOWN	-0.470640224066409	0.662376852786781	Vascular smooth muscle contraction: ACTA2
P-hsa03320-31	PPAR signaling pathway: CD36	0.644577241247958	DOWN	-0.461714288782391	0.668469709497277	PPAR signaling pathway: CD36
P-hsa04976-95 96	Bile secretion: SLC51A SLC51B	0.648453375711504	DOWN	-0.430879239619419	0.671948063237283	Bile secretion: SLC51A SLC51B
P-hsa04068-14	FoxO signaling pathway: G6PC	0.670987307871221	DOWN	-0.425199098984135	0.694739070981707	FoxO signaling pathway: G6PC
P-hsa04390-96	Hippo signaling pathway: FGF1	0.681668557338916	UP	0.410593023064833	0.705231055703525	Hippo signaling pathway: FGF1
P-hsa04360-3	Axon guidance: GNAI1	0.68226385959933	DOWN	-0.409781574402649	0.705279989802681	Axon guidance: GNAI1
P-hsa04970-28	Salivary secretion: AQP5	0.699611402841106	DOWN	-0.386249563199329	0.722632323801368	Salivary secretion: AQP5
P-hsa04340-51	Hedgehog signaling pathway: CCND1*	0.706837755716303	DOWN	-0.376512179253127	0.729510979636634	Hedgehog signaling pathway: CCND1*
P-hsa04330-19	Notch signaling pathway: DTX2	0.715300888017373	UP	0.365151897982559	0.737654040767916	Notch signaling pathway: DTX2
P-hsa04014-66	Ras signaling pathway: RAF1*	0.724407499662992	UP	0.352980168049807	0.746447119348495	Ras signaling pathway: RAF1*
P-hsa04932-31 133	Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA	0.748264995444028	DOWN	-0.321333670224652	0.770413639309171	Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA
P-hsa04015-100 101 48	Rap1 signaling pathway: PRKCI PARD6A PARD3	0.761831886324534	DOWN	-0.303481799656615	0.78375510607488	Rap1 signaling pathway: PRKCI PARD6A PARD3
P-hsa04152-58	AMPK signaling pathway: SCD	0.768023222689079	UP	0.295367313034781	0.789493520447959	AMPK signaling pathway: SCD
P-hsa04722-50	Neurotrophin signaling pathway: RHOA	0.776094084524243	DOWN	-0.284818480426396	0.797153301502554	Neurotrophin signaling pathway: RHOA
P-hsa04390-75	Hippo signaling pathway: NKD1	0.777337928691902	UP	0.283195583102029	0.797794189973268	Hippo signaling pathway: NKD1
P-hsa04340-20 22	Hedgehog signaling pathway: GLI1 SUFU*	0.77796006508145	UP	0.282384134439845	0.797796497019782	Hedgehog signaling pathway: GLI1 SUFU*
P-hsa04810-30	Regulation of actin cytoskeleton: VCL*	0.78793335217486	DOWN	-0.26940095584491	0.807380751790641	Regulation of actin cytoskeleton: VCL*
P-hsa04930-3	Type II diabetes mellitus: SLC2A4	0.789807275008476	DOWN	-0.266966609858359	0.808657090641137	Type II diabetes mellitus: SLC2A4
P-hsa04920-43	Adipocytokine signaling pathway: C00162	0.791682414227297	UP	0.264532263871809	0.809932644761948	Adipocytokine signaling pathway: C00162
P-hsa04340-40	Hedgehog signaling pathway: SUFU	0.793558759501567	DOWN	-0.262097917885259	0.811207405463476	Hedgehog signaling pathway: SUFU
P-hsa04662-10	B cell receptor signaling pathway: GSK3B	0.799821821096513	UP	0.253983431263424	0.816960860120009	B cell receptor signaling pathway: GSK3B
P-hsa04970-39	Salivary secretion: KCNN4	0.817425785251411	DOWN	-0.231262868722287	0.834279925153502	Salivary secretion: KCNN4
P-hsa04919-42	Thyroid hormone signaling pathway: SLC2A1	0.820579340625446	DOWN	-0.22720562541137	0.83683487431454	Thyroid hormone signaling pathway: SLC2A1
P-hsa03320-37	PPAR signaling pathway: HMGCS2	0.827527312161785	DOWN	-0.218279690127352	0.840590095305617	PPAR signaling pathway: HMGCS2
P-hsa03320-46	PPAR signaling pathway: APOA2	0.827527312161785	DOWN	-0.218279690127352	0.840590095305617	PPAR signaling pathway: APOA2
P-hsa03320-57	PPAR signaling pathway: APOC3	0.827527312161785	DOWN	-0.218279690127352	0.840590095305617	PPAR signaling pathway: APOC3
P-hsa03320-64	PPAR signaling pathway: APOA5	0.827527312161785	DOWN	-0.218279690127352	0.840590095305617	PPAR signaling pathway: APOA5
P-hsa03320-44	PPAR signaling pathway: FABP1	0.827527312161785	DOWN	-0.218279690127352	0.840590095305617	PPAR signaling pathway: FABP1
P-hsa04068-52	FoxO signaling pathway: CAT	0.830057228339453	DOWN	-0.215033895478618	0.842494994379239	FoxO signaling pathway: CAT
P-hsa04010-67	MAPK signaling pathway: ELK1	0.844637676673143	UP	0.196370576248398	0.85661835293801	MAPK signaling pathway: ELK1
P-hsa04115-25	p53 signaling pathway: CD82	0.848450256121555	UP	0.191501884275297	0.859807464274363	p53 signaling pathway: CD82
P-hsa04390-74	Hippo signaling pathway: AXIN1	0.852266384393056	UP	0.186633192302197	0.862995150837029	Hippo signaling pathway: AXIN1
P-hsa04742-23 45	Taste transduction: PKD1L3 PKD2L1	0.860219940473731	DOWN	-0.176490084024903	0.870364043545355	Taste transduction: PKD1L3 PKD2L1
P-hsa04740-33	Olfactory transduction: CNGA3*	0.883227745277978	DOWN	-0.147277932186299	0.892941169028089	Olfactory transduction: CNGA3*
P-hsa04950-18	Maturity onset diabetes of the young: SLC2A2	0.893811166849407	UP	0.133889029260271	0.902931688960115	Maturity onset diabetes of the young: SLC2A2
P-hsa04920-26	Adipocytokine signaling pathway: NPY	0.900231572705499	DOWN	-0.125774542638437	0.90870434044861	Adipocytokine signaling pathway: NPY
P-hsa04340-52	Hedgehog signaling pathway: BCL2*	0.90344425220949	UP	0.12171729932752	0.911232564728537	Hedgehog signaling pathway: BCL2*
P-hsa04010-117	MAPK signaling pathway: JUND	0.914378880904529	UP	0.107922672070401	0.921539248022028	MAPK signaling pathway: JUND
P-hsa04340-13	Hedgehog signaling pathway: GLI1*	0.923396146426283	DOWN	-0.0965623907998322	0.929898936189849	Hedgehog signaling pathway: GLI1*
P-hsa04068-96	FoxO signaling pathway: CCNG2	0.927263773052421	UP	0.0916936988267314	0.933063702829137	FoxO signaling pathway: CCNG2
P-hsa04015-92	Rap1 signaling pathway: C00076*	0.936617456710063	DOWN	-0.0799276932250712	0.941739583426446	Rap1 signaling pathway: C00076*
P-hsa04666-49	Fc gamma R-mediated phagocytosis: ARF6*	0.944688055151505	DOWN	-0.0697845849477779	0.949112823559708	Fc gamma R-mediated phagocytosis: ARF6*
P-hsa04520-9 57	Adherens junction: LEF1 CTNNB1	0.953733829276183	UP	0.0584243036772094	0.957453539998788	Adherens junction: LEF1 CTNNB1
P-hsa04024-113	cAMP signaling pathway: PTCH1	0.956319482509554	DOWN	-0.0551785090284755	0.959300992977238	cAMP signaling pathway: PTCH1
P-hsa04310-16	Wnt signaling pathway: CAMK2A	0.96019881584704	UP	0.0503098170553747	0.962442271024253	Wnt signaling pathway: CAMK2A
P-hsa04068-13	FoxO signaling pathway: PCK1	0.993849358502372	UP	0.00811448662183463	0.99539620575296	FoxO signaling pathway: PCK1
P-hsa04750-8	Inflammatory mediator regulation of TRP channels: ASIC2	1	0	0	1	Inflammatory mediator regulation of TRP channels: ASIC2
P-hsa04960-15	Aldosterone-regulated sodium reabsorption: C00762	1	0	0	1	Aldosterone-regulated sodium reabsorption: C00762