p.value UP.DOWN statistic FDRp.value path.name hsa04211__43 59 60 61 4.24570997314509e-26 UP 10.5673831097541 1.65192913469216e-23 Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101 hsa04922__37 4.48021749684416e-26 DOWN -10.5624140234743 1.65192913469216e-23 Glucagon signaling pathway: PYGB hsa04728__70 73 5.60952553516905e-26 DOWN -10.5412954067852 1.65192913469216e-23 Dopaminergic synapse: KIF5A GRIA1 hsa04530__11 24 23 7.59808408605911e-26 DOWN -10.5127231606764 1.65192913469216e-23 Tight junction: TJP1 YBX3 CDK4 hsa04611__43 8.22286475747012e-26 DOWN -10.5052695312567 1.65192913469216e-23 Platelet activation: MYL12B hsa04931__13 8.44223652889283e-26 DOWN -10.5027849881168 1.65192913469216e-23 Insulin resistance: AKT2 hsa05131__38 8.55408779342256e-26 UP 10.5015427165469 1.65192913469216e-23 Shigellosis: CXCL8 hsa04261__39 9.01637173183516e-26 DOWN -10.4965736302671 1.65192913469216e-23 Adrenergic signaling in cardiomyocytes: SCN1B hsa04922__70 9.13575983223795e-26 DOWN -10.4953313586971 1.65192913469216e-23 Glucagon signaling pathway: PFKFB1 hsa04014__26 1.01490099009131e-25 DOWN -10.4853931861376 1.65192913469216e-23 Ras signaling pathway: PRKCA hsa04750__8 1.23484931824485e-25 DOWN -10.4667591125883 1.65192913469216e-23 Inflammatory mediator regulation of TRP channels: ASIC2 hsa05212__34 1.2686749496524e-25 UP 10.4642745694485 1.65192913469216e-23 Pancreatic cancer: E2F1 hsa04742__46 1.3023257844905e-25 DOWN -10.4617900263086 1.65192913469216e-23 Taste transduction: P2RY1 hsa05214__35 1.30238948304559e-25 UP 10.4617900263086 1.65192913469216e-23 Glioma: E2F1 hsa04261__72 1.3195782295098e-25 DOWN -10.4605477547386 1.65192913469216e-23 Adrenergic signaling in cardiomyocytes: ATP2B1 hsa05200__168 1.44635988453578e-25 UP 10.451851853749 1.65192913469216e-23 Pathways in cancer: E2F1 hsa05221__41 1.56458830164828e-25 DOWN -10.4443982243293 1.65192913469216e-23 Acute myeloid leukemia: MAPK1 hsa04022__43 1.64867833670061e-25 DOWN -10.4394291380495 1.65192913469216e-23 cGMP-PKG signaling pathway: MAPK1 hsa04024__9 95 1.67039135493087e-25 DOWN -10.4381868664796 1.65192913469216e-23 cAMP signaling pathway: ATP1B4 FXYD1 hsa04115__52 53 1.78328098602363e-25 UP 10.4319755086298 1.6753924863692e-23 p53 signaling pathway: CDK4 CCND1 hsa05152__98 2.31558041620551e-25 UP 10.4071300772309 1.90648631118595e-23 Tuberculosis: IL23A hsa04960__3 2.40798047370716e-25 DOWN -10.4034032625211 1.90648631118595e-23 Aldosterone-regulated sodium reabsorption: SCNN1A hsa04960__4 2.43955995635985e-25 DOWN -10.4021609909511 1.90648631118595e-23 Aldosterone-regulated sodium reabsorption: ATP1B4 hsa04950__20 2.43958523679229e-25 UP 10.4021609909511 1.90648631118595e-23 Maturity onset diabetes of the young: NKX6-1 hsa04014__30 2.60388146140984e-25 DOWN -10.3959496331014 1.90648631118595e-23 Ras signaling pathway: C01245 hsa04970__18 2.63803321398801e-25 DOWN -10.3947073615314 1.90648631118595e-23 Salivary secretion: VAMP2 hsa04919__26 2.77913609121784e-25 DOWN -10.3897382752516 1.93407285755493e-23 Thyroid hormone signaling pathway: THRB hsa04350__27 3.1245497912298e-25 UP 10.3785578311221 2.05100151400869e-23 TGF-beta signaling pathway: ACVR2A* hsa04152__54 3.16546268793252e-25 DOWN -10.3773155595522 2.05100151400869e-23 AMPK signaling pathway: SLC2A4* hsa04152__77 3.69983511843144e-25 UP 10.3624083007128 2.31733006251089e-23 AMPK signaling pathway: CCND1 hsa04015__96 3.89711154399071e-25 DOWN -10.357439214433 2.33725185972782e-23 Rap1 signaling pathway: PLCE1 hsa04022__44 4.10480635290144e-25 DOWN -10.3524701281532 2.33725185972782e-23 cGMP-PKG signaling pathway: BAD hsa04261__23 4.10480635290144e-25 DOWN -10.3524701281532 2.33725185972782e-23 Adrenergic signaling in cardiomyocytes: SLC9A1 hsa04911__4 4.37990836007428e-25 DOWN -10.3462587703035 2.38207941908011e-23 Insulin secretion: CACNA1C hsa05120__20 4.43708247300713e-25 UP 10.3450164987335 2.38207941908011e-23 Epithelial cell signaling in Helicobacter pylori infection: CXCL8 hsa04066__89 4.79599160527773e-25 DOWN -10.3375628693139 2.43375349335663e-23 HIF-1 signaling pathway: CDKN1A hsa04151__105 62 4.92190701157807e-25 UP 10.335078326174 2.43375349335663e-23 PI3K-Akt signaling pathway: CCND1 CDK2 hsa04724__44 4.92190701157807e-25 DOWN -10.335078326174 2.43375349335663e-23 Glutamatergic synapse: PRKACA* hsa04540__1 5.1835233135041e-25 DOWN -10.3301092398942 2.49739495027544e-23 Gap junction: C00681 hsa04020__22 6.13314477860184e-25 DOWN -10.3139597094849 2.88104475974821e-23 Calcium signaling pathway: C00575 hsa04261__4 6.54278924058917e-25 DOWN -10.3077483516351 2.96518848940743e-23 Adrenergic signaling in cardiomyocytes: SLC8A1 hsa04261__20 6.62788273310869e-25 DOWN -10.3065060800652 2.96518848940743e-23 Adrenergic signaling in cardiomyocytes: ATP1B4 hsa05231__48 7.44478037728312e-25 DOWN -10.2953256359357 3.25319589044534e-23 Choline metabolism in cancer: WAS hsa04350__21 8.46982480702352e-25 DOWN -10.2829029202362 3.61700018463573e-23 TGF-beta signaling pathway: CDKN2B hsa04310__31 8.91794611663607e-25 UP 10.2779338339564 3.642787120252e-23 Wnt signaling pathway: MMP7 hsa05220__50 8.91794611663607e-25 DOWN -10.2779338339564 3.642787120252e-23 Chronic myeloid leukemia: MAPK1 hsa04919__46 1.00139270961354e-24 DOWN -10.2667533898269 3.9113718508209e-23 Thyroid hormone signaling pathway: ATP1B4 hsa04723__73 1.04081209441748e-24 DOWN -10.263026575117 3.9113718508209e-23 Retrograde endocannabinoid signaling: MAPK14* hsa04723__68 1.04081209441748e-24 DOWN -10.263026575117 3.9113718508209e-23 Retrograde endocannabinoid signaling: MAPK14 hsa04913__35 1.04081209441748e-24 DOWN -10.263026575117 3.9113718508209e-23 Ovarian steroidogenesis: HSD17B2 hsa04921__58 1.08176831619411e-24 DOWN -10.2592997604072 3.98557385515438e-23 Oxytocin signaling pathway: MEF2C hsa05034__62 1.2301672918543e-24 DOWN -10.2468770447077 4.4451621949889e-23 Alcoholism: NPY hsa04022__23 1.34587770848947e-24 UP 10.2381811437181 4.68315595231798e-23 cGMP-PKG signaling pathway: CACNA1C hsa04931__61 1.34587770848947e-24 DOWN -10.2381811437181 4.68315595231798e-23 Insulin resistance: ACACB hsa04916__7 1.41677333281666e-24 DOWN -10.2332120574383 4.84021289520455e-23 Melanogenesis: TYRP1 hsa03320__31 1.73929482192488e-24 DOWN -10.2133357123192 5.83595530428009e-23 PPAR signaling pathway: CD36 hsa04210__119 1.87815608653359e-24 DOWN -10.2058820828995 6.08457808033899e-23 Apoptosis: BCL2* hsa04910__32 1.87815608653359e-24 DOWN -10.2058820828995 6.08457808033899e-23 Insulin signaling pathway: EIF4E hsa04728__74 1.92684092384635e-24 DOWN -10.2033975397596 6.13649846763948e-23 Dopaminergic synapse: GRIN2A hsa05219__27 2.00222163645217e-24 DOWN -10.1996707250497 6.27029075815606e-23 Bladder cancer: RPS6KA5 hsa04919__39 2.27521937550491e-24 DOWN -10.1872480093503 7.00842165012085e-23 Thyroid hormone signaling pathway: ESR1 hsa04919__28 2.39446852854956e-24 DOWN -10.1822789230705 7.25678445991069e-23 Thyroid hormone signaling pathway: RCAN1 hsa04071__48 2.55221030201441e-24 DOWN -10.1760675652208 7.61206850394455e-23 Sphingolipid signaling pathway: SMPD1 hsa04728__68 3.01240939775636e-24 DOWN -10.1599180348114 8.84424571622532e-23 Dopaminergic synapse: CACNA1C hsa04022__46 3.33547892323878e-24 DOWN -10.1499798622519 9.47409457312225e-23 cGMP-PKG signaling pathway: VASP hsa04724__68 3.33547892323878e-24 DOWN -10.1499798622519 9.47409457312225e-23 Glutamatergic synapse: MAPK1 hsa04919__40 3.37820296114524e-24 DOWN -10.1487375906819 9.47409457312225e-23 Thyroid hormone signaling pathway: RCAN2 hsa04630__1 3.4652839030611e-24 UP 10.146253047542 9.57539478507617e-23 Jak-STAT signaling pathway: MYC hsa05032__13 3.5545878155849e-24 DOWN -10.1437685044021 9.66367254121567e-23 Morphine addiction: PRKACA hsa04014__69 3.60009088815911e-24 DOWN -10.1425262328322 9.66367254121567e-23 Ras signaling pathway: PLCE1* hsa04066__61 4.19326468178687e-24 DOWN -10.1276189739928 1.109738639025e-22 HIF-1 signaling pathway: HMOX1 hsa04390__90 5.20267751169309e-24 UP 10.1065003573037 1.35775431173213e-22 Hippo signaling pathway: BBC3 hsa04910__48 6.05668011309884e-24 DOWN -10.0915930984644 1.47749601379192e-22 Insulin signaling pathway: PPARGC1A hsa04972__39 6.05668011309884e-24 DOWN -10.0915930984644 1.47749601379192e-22 Pancreatic secretion: KCNMA1* hsa04530__20 22 6.13381911946942e-24 DOWN -10.0903508268944 1.47749601379192e-22 Tight junction: ACTB MYL12B hsa05205__30 6.13381911946942e-24 DOWN -10.0903508268944 1.47749601379192e-22 Proteoglycans in cancer: FLNA hsa04742__54 6.21132522065683e-24 DOWN -10.0891085553245 1.47749601379192e-22 Taste transduction: P2RX2* hsa04742__40 6.21132522065683e-24 DOWN -10.0891085553245 1.47749601379192e-22 Taste transduction: P2RX2 hsa04022__49 6.21193108512837e-24 DOWN -10.0891085553245 1.47749601379192e-22 cGMP-PKG signaling pathway: ATP1B4 hsa04920__43 6.29102816000831e-24 DOWN -10.0878662837545 1.47760523908195e-22 Adipocytokine signaling pathway: C00162 hsa05164__90 6.53435380288231e-24 DOWN -10.0841394690447 1.51580874019949e-22 Influenza A: MAPK1 hsa03320__44 7.1389626742549e-24 DOWN -10.075443568055 1.63586717864939e-22 PPAR signaling pathway: FABP1 hsa04066__88 7.50899668569408e-24 DOWN -10.0704744817753 1.69992828583364e-22 HIF-1 signaling pathway: BCL2 hsa03320__26 7.60443501742314e-24 DOWN -10.0692322102053 1.70103969020691e-22 PPAR signaling pathway: CPT2 hsa03320__20 8.51927109251722e-24 DOWN -10.0580517660758 1.82692633596818e-22 PPAR signaling pathway: SCP2 hsa04914__11 8.62741797530062e-24 UP 10.0568094945058 1.82692633596818e-22 Progesterone-mediated oocyte maturation: CDK1 hsa05030__37 8.62741797530062e-24 DOWN -10.0568094945058 1.82692633596818e-22 Cocaine addiction: PRKACA hsa05214__52 8.62741797530062e-24 UP 10.0568094945058 1.82692633596818e-22 Glioma: E2F1* hsa04152__87 8.73692435878218e-24 DOWN -10.0555672229359 1.82692633596818e-22 AMPK signaling pathway: CD36 hsa05214__23 8.84780716195339e-24 DOWN -10.0543249513659 1.82692633596818e-22 Glioma: MAPK1 hsa05214__56 8.84780716195339e-24 DOWN -10.0543249513659 1.82692633596818e-22 Glioma: MAPK1* hsa05161__213 9.07377074779554e-24 UP 10.0518404082261 1.85321904729433e-22 Hepatitis B: E2F1 hsa05012__71 1.01634142982195e-23 DOWN -10.0406599640965 2.05344682433919e-22 Parkinson's disease: PRKACA* hsa04014__42 1.04226265378527e-23 DOWN -10.0381754209566 2.06148581732897e-22 Ras signaling pathway: PLA2G4B hsa05216__15 1.04226265378527e-23 UP 10.0381754209566 2.06148581732897e-22 Thyroid cancer: CCND1 hsa03320__22 1.09608517410992e-23 DOWN -10.0332063346768 2.14535837724223e-22 PPAR signaling pathway: ACADM hsa04510__44 1.2907409909314e-23 DOWN -10.0170568042675 2.47479828771438e-22 Focal adhesion: BCL2 hsa04914__15 1.2907409909314e-23 UP 10.0170568042675 2.47479828771438e-22 Progesterone-mediated oocyte maturation: ANAPC10 hsa05210__21 1.55817688530332e-23 UP 9.99842273071833 2.95738824998478e-22 Colorectal cancer: BIRC5 hsa03460__7 1.63832064631152e-23 UP 9.99345364443854 3.07840449441934e-22 Fanconi anemia pathway: FANCI hsa05166__60 1.95232794048736e-23 UP 9.97606184245929 3.63210316849084e-22 HTLV-I infection: POLD3 hsa04068__41 2.32582223701259e-23 DOWN -9.95867004048003 4.28452939543791e-22 FoxO signaling pathway: CDKN2B hsa04914__29 2.44487027344401e-23 UP 9.95370095420024 4.46010800369057e-22 Progesterone-mediated oocyte maturation: CDK2 hsa04022__50 2.70169408939389e-23 DOWN -9.94376278164066 4.88123384035684e-22 cGMP-PKG signaling pathway: ATP2B1 hsa05161__32 2.80469829274086e-23 DOWN -9.94003596693082 5.01907437339055e-22 Hepatitis B: STAT3 hsa04151__35 3.06040942485999e-23 UP 9.93134006594119 5.42500878236974e-22 PI3K-Akt signaling pathway: CCND1 hsa05216__11 3.29787114514449e-23 UP 9.92388643652151 5.79130830067897e-22 Thyroid cancer: MYC hsa05164__78 3.50962370808965e-23 UP 9.91767507867178 6.10609532175969e-22 Influenza A: GSK3B hsa04913__19 3.68867255786253e-23 DOWN -9.91270599239199 6.35873003323274e-22 Ovarian steroidogenesis: STAR hsa05200__224 3.7815591412789e-23 UP 9.9102214492521 6.40139605987663e-22 Pathways in cancer: MYC*** hsa05221__12 3.7815591412789e-23 UP 9.9102214492521 6.40139605987663e-22 Acute myeloid leukemia: MYC hsa04742__49 3.92524805173169e-23 UP 9.90649463454226 6.58530454393201e-22 Taste transduction: HTR1A hsa04072__3 4.12527362655589e-23 DOWN -9.90152554826247 6.74033838634653e-22 Phospholipase D signaling pathway: MAPK1 hsa05200__223 4.12527362655589e-23 UP 9.90152554826247 6.74033838634653e-22 Pathways in cancer: CCND1**** hsa05221__17 4.12527362655589e-23 UP 9.90152554826247 6.74033838634653e-22 Acute myeloid leukemia: CCND1 hsa05166__114 112 113 4.28188531329482e-23 DOWN -9.89779873355263 6.93591595144911e-22 HTLV-I infection: DLG1 CTNNB1 APC2 hsa04390__18 4.38954891019288e-23 UP 9.89531419041273 7.04954051474566e-22 Hippo signaling pathway: MOB1A hsa04911__56 4.72888276005999e-23 DOWN -9.88786056099305 7.53014466623112e-22 Insulin secretion: CAMK2A* hsa04211__50 5.03140378958544e-23 DOWN -9.88164920314331 7.9445443030513e-22 Longevity regulating pathway - mammal: PPARGC1A* hsa05200__189 5.09416850426507e-23 UP 9.88040693157337 7.97661884959506e-22 Pathways in cancer: BIRC5 hsa04917__71 5.35307347524114e-23 UP 9.87543784529358 8.31274798345298e-22 Prolactin signaling pathway: CCND1* hsa04630__31 6.85635664188153e-23 UP 9.85059241389464 1.05599132213897e-21 Jak-STAT signaling pathway: BCL2L1 hsa04727__35 7.66262149249827e-23 DOWN -9.83941196976512 1.16113433745196e-21 GABAergic synapse: PRKACA hsa05012__70 7.66262149249827e-23 DOWN -9.83941196976512 1.16113433745196e-21 Parkinson's disease: PRKACA hsa04630__28 7.95170179461879e-23 UP 9.83568515505528 1.1952998137671e-21 Jak-STAT signaling pathway: CCND1 hsa04976__37 8.6688570597345e-23 DOWN -9.82698925406565 1.29276050914612e-21 Bile secretion: ABCB11 hsa05205__183 8.77643443679156e-23 UP 9.8257469824957 1.29849766194735e-21 Proteoglycans in cancer: VEGFA* hsa05200__191 9.92729476482608e-23 UP 9.81332426679623 1.45729584868033e-21 Pathways in cancer: CCND1* hsa04066__56 1.03008204501982e-22 DOWN -9.80959745208639 1.50040632759089e-21 HIF-1 signaling pathway: TEK hsa05215__14 1.068825346411e-22 UP 9.80587063737655 1.54486371223559e-21 Prostate cancer: CCND1 hsa04261__73 1.10901060309948e-22 DOWN -9.80214382266671 1.59071062841521e-21 Adrenergic signaling in cardiomyocytes: KCNE1 hsa04921__43 1.15069090313479e-22 UP 9.79841700795687 1.63799106590173e-21 Oxytocin signaling pathway: CACNG3 hsa05210__39 1.16492602110734e-22 DOWN -9.79717473638692 1.64578646139902e-21 Colorectal cancer: BAD hsa04911__31 1.20868564425079e-22 DOWN -9.79344792167708 1.69486591458749e-21 Insulin secretion: CAMK2A hsa05030__76 1.25407181977736e-22 DOWN -9.78972110696724 1.74548218471234e-21 Cocaine addiction: PDYN hsa04930__26 1.36663840263909e-22 UP 9.78102520597761 1.88817173423444e-21 Type II diabetes mellitus: INS* hsa05210__22 1.43539404909079e-22 UP 9.77605611969782 1.96431368579274e-21 Colorectal cancer: MYC hsa04664__46 1.45311124175195e-22 DOWN -9.77481384812787 1.96431368579274e-21 Fc epsilon RI signaling pathway: PLA2G4B hsa05169__31 1.45311124175195e-22 UP 9.77481384812787 1.96431368579274e-21 Epstein-Barr virus infection: MYC hsa04910__42 1.5449965527131e-22 DOWN -9.76860249027814 2.07360608753422e-21 Insulin signaling pathway: PCK1 hsa04062__40 1.58334053535561e-22 DOWN -9.76611794713824 2.0804873188344e-21 Chemokine signaling pathway: PRKACA hsa04722__38 1.58334053535561e-22 DOWN -9.76611794713824 2.0804873188344e-21 Neurotrophin signaling pathway: ATF4 hsa04913__12 1.58334053535561e-22 DOWN -9.76611794713824 2.0804873188344e-21 Ovarian steroidogenesis: HSD3B1 hsa03320__21 1.62262622788476e-22 DOWN -9.76363340399835 2.11730186263574e-21 PPAR signaling pathway: ACAA1 hsa04724__67 1.68337067153679e-22 DOWN -9.75990658928851 2.18141620125353e-21 Glutamatergic synapse: PLD1 hsa05220__25 1.70411481023627e-22 UP 9.75866431771856 2.19317241673558e-21 Chronic myeloid leukemia: BCL2L1* hsa04014__24 1.72511194256293e-22 DOWN -9.75742204614862 2.20509206807874e-21 Ras signaling pathway: PLD1 hsa04066__43 1.76787743528208e-22 DOWN -9.75493750300872 2.22942396033223e-21 HIF-1 signaling pathway: PFKL hsa04151__73 1.76787743528208e-22 DOWN -9.75493750300872 2.22942396033223e-21 PI3K-Akt signaling pathway: MAPK1 hsa04152__78 1.83400063682783e-22 UP 9.75121068829888 2.28217695139039e-21 AMPK signaling pathway: CCNA2 hsa04550__34 1.83400063682783e-22 DOWN -9.75121068829888 2.28217695139039e-21 Signaling pathways regulating pluripotency of stem cells: MAPK1* hsa04970__12 1.85654164167655e-22 DOWN -9.74996841672893 2.29502746362516e-21 Salivary secretion: BEST2 hsa05014__31 34 1.94968788496244e-22 DOWN -9.74499933044915 2.39442061166302e-21 Amyotrophic lateral sclerosis (ALS): NEFL PRPH hsa04931__40 1.97367765611436e-22 UP 9.7437570588792 2.40814306223304e-21 Insulin resistance: PRKCZ hsa04261__36 1.99795955465404e-22 DOWN -9.74251478730925 2.42060331896764e-21 Adrenergic signaling in cardiomyocytes: MAPK1 hsa05161__207 2.02253709993571e-22 UP 9.74127251573931 2.42060331896764e-21 Hepatitis B: CDK2 hsa05161__219 2.02253709993571e-22 UP 9.74127251573931 2.42060331896764e-21 Hepatitis B: CDK2* hsa05215__22 2.04927373390119e-22 UP 8.93255372370382 2.4370793329116e-21 Prostate cancer: C16038 hsa04010__131 2.07259341829671e-22 UP 9.73878797259941 2.44931008363492e-21 MAPK signaling pathway: MYC hsa04261__37 2.09807944172684e-22 DOWN -9.73754570102946 2.46393204437796e-21 Adrenergic signaling in cardiomyocytes: CREB3 hsa03320__37 2.2576409572959e-22 DOWN -9.73009207160978 2.6185847893574e-21 PPAR signaling pathway: HMGCS2 hsa04931__149 2.2576409572959e-22 DOWN -9.73009207160978 2.6185847893574e-21 Insulin resistance: ACACB* hsa04066__45 2.28537800867127e-22 DOWN -9.72884980003984 2.63449403576277e-21 HIF-1 signaling pathway: ALDOA hsa05210__23 2.42920370242528e-22 UP 9.7226384421901 2.78321570540067e-21 Colorectal cancer: CCND1 hsa04925__3 2.45902600635754e-22 DOWN -9.72139617062015 2.80030900966413e-21 Aldosterone synthesis and secretion: ITPR1 hsa04064__55 2.48921062289948e-22 DOWN -9.72015389905021 2.80073458708271e-21 NF-kappa B signaling pathway: CXCL12 hsa04724__3 2.48921062289948e-22 DOWN -9.72015389905021 2.80073458708271e-21 Glutamatergic synapse: GRIK1 hsa04066__44 2.55068426399317e-22 DOWN -9.71766935591031 2.85281888812094e-21 HIF-1 signaling pathway: GAPDH hsa05160__15 16 2.58198215364078e-22 DOWN -9.71642708434037 2.87073637082309e-21 Hepatitis C: TRAF6 RIPK1 hsa04916__8 2.67817440224052e-22 DOWN -9.71270026963053 2.94285947474265e-21 Melanogenesis: TYR* hsa05205__431 2.67817440224052e-22 DOWN -9.71270026963053 2.94285947474265e-21 Proteoglycans in cancer: CDKN1A* hsa04923__16 2.84643725686885e-22 DOWN -9.70648891178079 3.10956721259103e-21 Regulation of lipolysis in adipocytes: PLIN1 hsa04071__1 2.91663494405908e-22 DOWN -9.7040043686409 3.16783645080174e-21 Sphingolipid signaling pathway: MAPK1 hsa04360__114 2.98854555452069e-22 DOWN -9.701519825501 3.22728568789907e-21 Axon guidance: RAF1 hsa05223__28 3.13767190402193e-22 UP 9.69655073922121 3.36896314723269e-21 Non-small cell lung cancer: RB1 hsa04115__11 12 3.37527448705246e-22 UP 9.68909710980153 3.58313037354326e-21 p53 signaling pathway: CDK2 CCNE1 hsa04211__42 3.37527448705246e-22 DOWN -9.68909710980153 3.58313037354326e-21 Longevity regulating pathway - mammal: PPARGC1A hsa05212__10 3.54348178949776e-22 UP 9.68412802352174 3.74056308003724e-21 Pancreatic cancer: BCL2L1 hsa04066__29 3.58681373047639e-22 DOWN -9.6828857519518 3.76515251372354e-21 HIF-1 signaling pathway: LDHA hsa04151__98 4.05003256948916e-22 UP 9.67046303625233 4.22778399892785e-21 PI3K-Akt signaling pathway: BCL2L1* hsa03460__27 4.14954513110462e-22 UP 9.66797849311243 4.28406335238768e-21 Fanconi anemia pathway: BRCA1 hsa04914__34 4.14954513110462e-22 DOWN -9.66797849311243 4.28406335238768e-21 Progesterone-mediated oocyte maturation: MAPK14 hsa04620__12 4.2002049801166e-22 DOWN -9.66673622154249 4.31266948504869e-21 Toll-like receptor signaling pathway: NFKB1 hsa04014__33 4.57237519808811e-22 UP 9.65804032055286 4.66928967239541e-21 Ras signaling pathway: BCL2L1 hsa04261__66 4.68457900523574e-22 DOWN -9.65555577741296 4.7580129463989e-21 Adrenergic signaling in cardiomyocytes: C01245 hsa04066__42 4.97714995503779e-22 DOWN -9.64934441956323 5.02799180941721e-21 HIF-1 signaling pathway: HK1 hsa03460__48 5.22416529752455e-22 UP 9.64437533328344 5.22138648619607e-21 Fanconi anemia pathway: RAD51 hsa04022__48 5.22416529752455e-22 DOWN -9.64437533328344 5.22138648619607e-21 cGMP-PKG signaling pathway: SLC8A2 hsa05200__53 5.4833059562327e-22 UP 9.63940624700365 5.45139253532341e-21 Pathways in cancer: BCL2L1 hsa05030__69 6.18813760042837e-22 DOWN -9.62698353130418 6.119742395371e-21 Cocaine addiction: PRKACA** hsa04370__15 6.2633699111148e-22 UP 9.62574125973424 6.16171312198152e-21 VEGF signaling pathway: PLA2G4B hsa04114__80 6.41656015834037e-22 UP 9.62325671659434 6.27953986329248e-21 Oocyte meiosis: CDC25C* hsa05218__21 6.49453975467322e-22 UP 9.62201444502439 6.2903299995005e-21 Melanoma: RB1 hsa05220__40 6.49453975467322e-22 UP 9.62201444502439 6.2903299995005e-21 Chronic myeloid leukemia: RB1 hsa05200__190 6.73414908397472e-22 UP 9.61828763031455 6.48895698912231e-21 Pathways in cancer: MYC* hsa05166__53 146 6.81594664893059e-22 DOWN -9.61704535874461 6.53426722109214e-21 HTLV-I infection: CREB1 CRTC2 hsa04611__34 7.0672844047547e-22 DOWN -9.61331854403477 6.74082608961121e-21 Platelet activation: C02198* hsa04726__41 7.50669314185735e-22 DOWN -9.60710718618503 7.08797809726129e-21 Serotonergic synapse: HTR3C hsa04742__57 7.50669314185735e-22 DOWN -9.60710718618503 7.08797809726129e-21 Taste transduction: HTR3C hsa04211__29 7.59779252009417e-22 DOWN -9.60586491461508 7.13812607262847e-21 Longevity regulating pathway - mammal: EIF4E hsa04919__29 8.26668234850984e-22 DOWN -9.59716901362546 7.72790852380597e-21 Thyroid hormone signaling pathway: HIF1A hsa03320__40 8.5708874800772e-22 DOWN -9.59344219891561 7.97262256191339e-21 PPAR signaling pathway: FABP4 hsa04152__64 8.77981784967619e-22 DOWN -9.59095765577572 8.00838725220464e-21 AMPK signaling pathway: ACACB hsa04723__40 8.77981784967619e-22 DOWN -9.59095765577572 8.00838725220464e-21 Retrograde endocannabinoid signaling: GRIA1 hsa04724__4 8.77981784967619e-22 DOWN -9.59095765577572 8.00838725220464e-21 Glutamatergic synapse: GRIA1 hsa05031__12 8.77981784967619e-22 DOWN -9.59095765577572 8.00838725220464e-21 Amphetamine addiction: GRIA1 hsa04022__65 9.78411107658911e-22 DOWN -9.5797772116462 8.88132594826615e-21 cGMP-PKG signaling pathway: PDE2A hsa05020__46 1.01435052171258e-21 DOWN -9.57605039693636 9.163291491817e-21 Prion diseases: PRKACA hsa05031__55 1.09019330676738e-21 DOWN -9.56859676751667 9.80130728907129e-21 Amphetamine addiction: GRIA1* hsa05221__35 1.10336812122121e-21 UP 9.56735449594673 9.87251761797453e-21 Acute myeloid leukemia: EIF4EBP1 hsa04610__11 1.14384509493735e-21 UP 9.56362768123689 1.01861845184232e-20 Complement and coagulation cascades: F2R hsa03320__42 1.25910741036723e-21 DOWN -9.55368950867731 1.11597303022643e-20 PPAR signaling pathway: ACOX1 hsa04919__45 1.27430016901367e-21 DOWN -9.55244723710736 1.12413615848671e-20 Thyroid hormone signaling pathway: SLC9A1 hsa04151__32 1.28967427815488e-21 UP 9.55120496553742 1.13238222834253e-20 PI3K-Akt signaling pathway: BCL2L1 hsa04922__50 1.33690624079891e-21 DOWN -9.54747815082758 1.16298464188017e-20 Glucagon signaling pathway: PCK1 hsa04960__27 1.33690624079891e-21 DOWN -9.54747815082758 1.16298464188017e-20 Aldosterone-regulated sodium reabsorption: KCNJ1 hsa04919__38 1.35302741022543e-21 DOWN -9.54623587925763 1.1715845639694e-20 Thyroid hormone signaling pathway: TP53 hsa04916__6 1.38584893776266e-21 DOWN -9.54375133611773 1.18904573244568e-20 Melanogenesis: DCT hsa04920__40 1.38584893776266e-21 DOWN -9.54375133611773 1.18904573244568e-20 Adipocytokine signaling pathway: PPARGC1A hsa04012__22 1.4365636271884e-21 UP 9.54002452140789 1.22695593431228e-20 ErbB signaling pathway: EIF4EBP1 hsa04660__40 41 1.48911373498361e-21 DOWN -9.53629770669805 1.26608357829602e-20 T cell receptor signaling pathway: LAT GRAP2 hsa04660__41 46 1.5809553655902e-21 DOWN -9.53008634884832 1.33811492429909e-20 T cell receptor signaling pathway: GRAP2 LCP2 hsa04919__18 1.63872731614796e-21 DOWN -9.52635953413848 1.38079310629687e-20 Thyroid hormone signaling pathway: STAT1 hsa04911__54 1.65844495388897e-21 DOWN -9.52511726256853 1.39116878051669e-20 Insulin secretion: RAB3A hsa04923__26 27 1.71895725850393e-21 DOWN -9.52139044785869 1.43552030610173e-20 Regulation of lipolysis in adipocytes: PNPLA2 ABHD5 hsa05212__14 1.93716890673859e-21 DOWN -9.50896773215922 1.61059308662027e-20 Pancreatic cancer: MAPK1 hsa04550__67 1.98397863568032e-21 UP 9.50648318901933 1.63318561970592e-20 Signaling pathways regulating pluripotency of stem cells: MYC* hsa04750__51 2.00764475368027e-21 UP 9.50524091744938 1.63318561970592e-20 Inflammatory mediator regulation of TRP channels: TRPV4 hsa04750__61 2.00764475368027e-21 UP 9.50524091744938 1.63318561970592e-20 Inflammatory mediator regulation of TRP channels: TRPV4* hsa04151__24 2.00780137388008e-21 UP 9.50524091744938 1.63318561970592e-20 PI3K-Akt signaling pathway: MYC hsa04530__20 37 2.00780137388008e-21 DOWN -9.50524091744938 1.63318561970592e-20 Tight junction: ACTB TJP3 hsa04340__50 2.13122635364108e-21 DOWN -9.49902955959964 1.72610962003948e-20 Hedgehog signaling pathway: BCL2 hsa04722__33 2.26215223137212e-21 DOWN -9.49281820174991 1.82428499688764e-20 Neurotrophin signaling pathway: BAD hsa05145__33 2.34449450029139e-21 DOWN -9.48909138704007 1.87459794299894e-20 Toxoplasmosis: STAT3 hsa05169__125 2.34449450029139e-21 DOWN -9.48909138704007 1.87459794299894e-20 Epstein-Barr virus infection: STAT3 hsa04723__42 2.57885196040745e-21 DOWN -9.47915321448049 2.04458347409519e-20 Retrograde endocannabinoid signaling: KCNJ3 hsa04723__50 2.57885196040745e-21 DOWN -9.47915321448049 2.04458347409519e-20 Retrograde endocannabinoid signaling: KCNJ3* hsa04022__45 2.80282922820854e-21 DOWN -9.47045731349086 2.21282189907725e-20 cGMP-PKG signaling pathway: CREB3 hsa04921__34 35 2.87028498435241e-21 DOWN -9.46797277035097 2.24719395233257e-20 Oxytocin signaling pathway: MYL9 ACTB hsa05166__136 139 2.87028498435241e-21 UP 9.46797277035097 2.24719395233257e-20 HTLV-I infection: TP53 TBPL2 hsa04380__72 2.93934624525643e-21 DOWN -9.46548822721107 2.29171435470408e-20 Osteoclast differentiation: MAPK1 hsa04666__29 3.11927355186381e-21 DOWN -9.45927686936134 2.42194834874054e-20 Fc gamma R-mediated phagocytosis: WAS hsa03320__25 3.59676724735746e-21 DOWN -9.44436961052198 2.78120397439698e-20 PPAR signaling pathway: EHHADH hsa04970__45 3.63959467899511e-21 DOWN -9.44312733895203 2.79140997387182e-20 Salivary secretion: KCNMA1 hsa03320__43 3.63967772005639e-21 DOWN -9.44312733895203 2.79140997387182e-20 PPAR signaling pathway: ILK hsa04022__37 38 3.72702350251123e-21 DOWN -9.44064279581213 2.8467793338287e-20 cGMP-PKG signaling pathway: ATP2A1 PLN hsa04360__59 3.90798219084298e-21 DOWN -9.43567370953235 2.96092682927176e-20 Axon guidance: MAPK1* hsa04911__24 3.90798219084298e-21 DOWN -9.43567370953235 2.96092682927176e-20 Insulin secretion: INS hsa05014__32 34 4.29636958601574e-21 DOWN -9.42573553697277 3.24211986029059e-20 Amyotrophic lateral sclerosis (ALS): NEFM PRPH hsa04115__29 5.70550596215824e-21 DOWN -9.39592101929404 4.28825828115813e-20 p53 signaling pathway: IGF1 hsa04726__10 5.98121092114423e-21 DOWN -9.39095193301426 4.47756785690438e-20 Serotonergic synapse: PRKACA hsa04014__44 6.57275126550498e-21 DOWN -9.38101376045468 4.90087286820788e-20 Ras signaling pathway: ETS1 hsa04922__59 6.65064817008705e-21 DOWN -9.37977148888473 4.91990862661164e-20 Glucagon signaling pathway: CPT1C hsa05215__13 6.65064817008705e-21 DOWN -9.37977148888473 4.91990862661164e-20 Prostate cancer: BCL2 hsa04961__13 7.13757534391588e-21 DOWN -9.37231785946505 5.25941336126194e-20 Endocrine and other factor-regulated calcium reabsorption: ATP2B1 hsa04024__91 7.57015458613801e-21 DOWN -9.36610650161531 5.55637518255989e-20 cAMP signaling pathway: GRIA1 hsa05200__215 7.6597318706338e-21 DOWN -9.36486423004537 5.60024754277079e-20 Pathways in cancer: CSF1R hsa04916__9 7.75035728614003e-21 DOWN -9.36362195847542 5.64454315529346e-20 Melanogenesis: PRKACA hsa03460__28 7.8420429551951e-21 UP 9.36237968690547 5.68926591228247e-20 Fanconi anemia pathway: RAD51C hsa04068__50 8.02864423833564e-21 DOWN -9.35989514376558 5.80223943224334e-20 FoxO signaling pathway: TNFSF10 hsa04925__18 8.12358479643738e-21 DOWN -9.35865287219563 5.84835855651564e-20 Aldosterone synthesis and secretion: PDE2A hsa04976__34 8.9241709502518e-21 UP 9.34871469963606 6.40019741050501e-20 Bile secretion: SLCO1B1 hsa04920__3 9.91835942329658e-21 DOWN -9.33753425550653 7.08615869063661e-20 Adipocytokine signaling pathway: C15493 hsa04931__87 1.0394656496698e-20 DOWN -9.33256516922675 7.39831801412709e-20 Insulin resistance: C00031* hsa03320__38 1.05172224451323e-20 DOWN -9.3313228976568 7.4573060280768e-20 PPAR signaling pathway: SORBS1 hsa04110__59 15 16 17 18 19 20 1.25367585402672e-20 UP 9.31268882410759 8.82268513002324e-20 Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 hsa04310__34 1.25367585402672e-20 UP 9.31268882410759 8.82268513002324e-20 Wnt signaling pathway: FOSL1 hsa04920__26 1.26842727156785e-20 DOWN -9.31144655253765 8.82731423435551e-20 Adipocytokine signaling pathway: NPY hsa05031__11 1.26842727156785e-20 UP 9.31144655253765 8.82731423435551e-20 Amphetamine addiction: GRIN3A hsa05031__54 1.26842727156785e-20 UP 9.31144655253765 8.82731423435551e-20 Amphetamine addiction: GRIN3A* hsa04725__61 1.40915421181981e-20 DOWN -9.30026610840813 9.77048252402001e-20 Cholinergic synapse: FOS hsa04914__30 1.42567780845395e-20 UP 9.29902383683818 9.84870809590061e-20 Progesterone-mediated oocyte maturation: CDK1* hsa04115__64 1.45941086013897e-20 UP 9.29653929369828 1.00448095465243e-19 p53 signaling pathway: PMAIP1 hsa04066__46 1.58367291264969e-20 DOWN -9.28784339270866 1.0860297090762e-19 HIF-1 signaling pathway: ENO1 hsa04024__24 1.67878125311728e-20 DOWN -9.28163203485892 1.14706544531177e-19 cAMP signaling pathway: PLN hsa03460__25 40 1.84283068019599e-20 UP 9.27169386229934 1.25459378553923e-19 Fanconi anemia pathway: MLH1 PMS2 hsa04064__97 2.14384481870587e-20 DOWN -9.25554433189003 1.45425430120879e-19 NF-kappa B signaling pathway: PLCG2 hsa04810__31 2.29869996517516e-20 DOWN -9.24809070247035 1.55368965272091e-19 Regulation of actin cytoskeleton: MSN hsa04664__3 4 5 2.32549946839464e-20 DOWN -9.24684843090041 1.56061894651952e-19 Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A hsa05034__61 2.32556309220577e-20 DOWN -9.24684843090041 1.56061894651952e-19 Alcoholism: CRH hsa04012__3 2.76780913350571e-20 DOWN -9.2282143573512 1.8507876732588e-19 ErbB signaling pathway: ELK1 hsa04923__52 53 2.83273492926342e-20 DOWN -9.22572981421131 1.88748543690992e-19 Regulation of lipolysis in adipocytes: PNPLA2 ABHD5* hsa05211__45 2.8991660201232e-20 DOWN -9.22324527107141 1.92492330452703e-19 Renal cell carcinoma: ETS1 hsa04923__66 3.03668278898608e-20 DOWN -9.21827618479162 2.00912921144537e-19 Regulation of lipolysis in adipocytes: LIPE hsa04970__32 3.07205761514836e-20 DOWN -9.21703391322168 2.02540219609255e-19 Salivary secretion: RYR3 hsa04510__47 3.10783978526502e-20 UP 9.21579164165173 2.03471461899407e-19 Focal adhesion: CCND1 hsa04666__20 3.10783978526502e-20 DOWN -9.21579164165173 2.03471461899407e-19 Fc gamma R-mediated phagocytosis: PLA2G4B hsa05020__49 3.48911129191238e-20 UP 9.20336892595226 2.27640281857756e-19 Prion diseases: BAX hsa04660__35 3.57073901256353e-20 DOWN -9.20088438281237 2.32159813308196e-19 T cell receptor signaling pathway: NFATC1 hsa04914__39 3.65425410450331e-20 DOWN -9.19839983967247 2.3677046421937e-19 Progesterone-mediated oocyte maturation: PIK3R5 hsa04530__22 33 4.00806513747976e-20 DOWN -9.1884616671129 2.58802556471631e-19 Tight junction: MYL12B CGN hsa04961__12 4.93271177827849e-20 DOWN -9.16610077885385 3.1741662436251e-19 Endocrine and other factor-regulated calcium reabsorption: SLC8A1 hsa04390__13 4.98985391151516e-20 UP 9.1648585072839 3.19997798625836e-19 Hippo signaling pathway: BIRC5 hsa04340__49 5.72876788840656e-20 UP 9.14995124844454 3.66134519126392e-19 Hedgehog signaling pathway: CCND1 hsa04370__36 6.20871371420642e-20 UP 9.14125534745491 3.95463493864199e-19 VEGF signaling pathway: NOS3 hsa04066__47 6.57565755009087e-20 DOWN -9.13504398960518 4.17420964075025e-19 HIF-1 signaling pathway: PGK1 hsa04930__3 6.72836541649749e-20 DOWN -9.13255944646528 4.25676721131272e-19 Type II diabetes mellitus: SLC2A4 hsa04660__44 7.12564083095069e-20 DOWN -9.12634808861555 4.49297957092495e-19 T cell receptor signaling pathway: PAK4 hsa03320__7 7.37504356818347e-20 DOWN -9.12262127390571 4.61923562153891e-19 PPAR signaling pathway: AQP7 hsa04010__58 7.37504356818347e-20 UP 9.12262127390571 4.61923562153891e-19 MAPK signaling pathway: CDC25B hsa04713__60 7.90001693562252e-20 DOWN -9.11516764448602 4.93160525648994e-19 Circadian entrainment: PER1 hsa04972__51 7.99103332082454e-20 DOWN -9.11392537291608 4.93919460849648e-19 Pancreatic secretion: CLCA1 hsa05161__69 7.99103332082454e-20 DOWN -9.11392537291608 4.93919460849648e-19 Hepatitis B: SMAD4 hsa05217__10 7.99103332082454e-20 DOWN -9.11392537291608 4.93919460849648e-19 Basal cell carcinoma: PTCH1* hsa04919__32 8.1761865538958e-20 DOWN -9.11144082977618 5.03706706058039e-19 Thyroid hormone signaling pathway: PLN hsa04924__31 9.27240572307153e-20 DOWN -9.09777584250677 5.69374194563771e-19 Renin secretion: C02135 hsa04664__23 9.93117193090914e-20 DOWN -9.09032221308708 6.07839480722419e-19 Fc epsilon RI signaling pathway: AKT3 hsa04725__50 1.08811619665098e-19 DOWN -9.08038404052751 6.61673247089707e-19 Cholinergic synapse: BCL2 hsa04921__77 1.08811619665098e-19 UP 9.08038404052751 6.61673247089707e-19 Oxytocin signaling pathway: KCNJ3 hsa04530__1 5 1.1785714441448e-19 DOWN -9.07168813953788 7.14366368886476e-19 Tight junction: IGSF5 IGSF5 hsa03320__53 1.33594464448286e-19 DOWN -9.05802315226846 8.07151121216493e-19 PPAR signaling pathway: ADIPOQ hsa05219__21 1.35124127044548e-19 UP 9.05678088069851 8.13776393322776e-19 Bladder cancer: RB1 hsa04151__2 1.38235564188716e-19 DOWN -9.05429633755862 8.29855032302225e-19 PI3K-Akt signaling pathway: EIF4E hsa05133__46 1.39816993971616e-19 DOWN -9.05305406598867 8.3667557857537e-19 Pertussis: CFL1 hsa04340__46 1.41417783845986e-19 DOWN -9.05181179441873 8.43568304274946e-19 Hedgehog signaling pathway: PRKACA hsa05212__54 1.44672376167017e-19 DOWN -9.04932725127883 8.60251249423497e-19 Pancreatic cancer: C00416 hsa04664__47 1.48000966563319e-19 DOWN -9.04684270813894 8.77267558903711e-19 Fc epsilon RI signaling pathway: MAPK8 hsa04152__62 1.49693528811927e-19 UP 9.04560043656899 8.845098762189e-19 AMPK signaling pathway: EIF4EBP1 hsa04115__43 57 1.56657178168052e-19 UP 9.04063135028921 9.19871368055533e-19 p53 signaling pathway: CDK1 CCNB3 hsa04360__101 103 1.56657178168052e-19 DOWN -9.04063135028921 9.19871368055533e-19 Axon guidance: DPYSL2 DPYSL5 hsa04151__103 1.69622132358197e-19 DOWN -9.03193544929958 9.92897154831938e-19 PI3K-Akt signaling pathway: BCL2* hsa04910__9 1.75497972164008e-19 DOWN -9.02820863458973 1.02410152079556e-18 Insulin signaling pathway: ELK1 hsa03460__16 34 1.9657471344279e-19 UP 9.01578591889026 1.14354144445512e-18 Fanconi anemia pathway: FANCM STRA13 hsa04270__48 1.98815189821802e-19 DOWN -9.01454364732032 1.15300537554063e-18 Vascular smooth muscle contraction: KCNMB2* hsa03320__62 2.05688050467733e-19 DOWN -9.01081683261048 1.18919337485806e-18 PPAR signaling pathway: UBC hsa05221__21 2.08032208990862e-19 DOWN -9.00957456104053 1.19905681194426e-18 Acute myeloid leukemia: PIM1 hsa04530__14 20 43 2.22654887569976e-19 DOWN -9.00212093162085 1.2794144762813e-18 Tight junction: CTNNA1 ACTB ACTN4 hsa04014__43 2.2775127500588e-19 DOWN -8.99963638848095 1.30470928578064e-18 Ras signaling pathway: ELK1 hsa05168__79 2.49315140416657e-19 UP 8.98969821592138 1.42390014845866e-18 Herpes simplex infection: EIF2S1 hsa04015__3 2.69830308153257e-19 DOWN -8.98100231493175 1.53639742127263e-18 Rap1 signaling pathway: MAPK1 hsa04621__29 2.75992187599656e-19 DOWN -8.97851777179186 1.56673510725001e-18 NOD-like receptor signaling pathway: CASP5 hsa04920__2 2.95324221765658e-19 DOWN -8.97106414237217 1.67142835149901e-18 Adipocytokine signaling pathway: C00638 hsa04660__43 3.08949387556077e-19 DOWN -8.96609505609239 1.74329098864225e-18 T cell receptor signaling pathway: RHOA hsa04713__61 3.82636927660474e-19 DOWN -8.94249189626339 2.15261912297614e-18 Circadian entrainment: FOS hsa04921__48 3.95761341685713e-19 UP 8.93876508155355 2.21980764485807e-18 Oxytocin signaling pathway: PRKAG2 hsa04971__52 53 4.13954633323853e-19 DOWN -8.93379599527376 2.31494272623667e-18 Gastric acid secretion: EZR ACTB hsa05034__99 4.18630567605589e-19 DOWN -8.93255372370382 2.33414491552197e-18 Alcoholism: PDYN hsa03320__27 4.32973710933313e-19 DOWN -8.92882690899398 2.4069751563423e-18 PPAR signaling pathway: CPT1C hsa04724__5 71 4.42796507367037e-19 UP 8.92634236585408 2.44714558239887e-18 Glutamatergic synapse: GRIN3A DLG4 hsa04921__55 4.42804416187129e-19 UP 8.92634236585408 2.44714558239887e-18 Oxytocin signaling pathway: PTGS2* hsa04152__61 5.23908697514721e-19 UP 8.90770829230488 2.88687519832892e-18 AMPK signaling pathway: RPS6KB1 hsa03460__16 49 5.4790939744293e-19 UP 8.90273920602509 3.01029753741306e-18 Fanconi anemia pathway: FANCM C19orf40 hsa04012__37 7 6.05953878458655e-19 DOWN -8.89155876189557 3.31949661114814e-18 ErbB signaling pathway: ERBB3 ERBB3 hsa04919__21 53 6.19655407526221e-19 DOWN -8.88907421875567 3.37487684272977e-18 Thyroid hormone signaling pathway: THRA C02465 hsa05200__194 6.19655407526221e-19 DOWN -8.88907421875567 3.37487684272977e-18 Pathways in cancer: BCL2 hsa04066__30 7.92123346773501e-19 DOWN -8.86174424421684 4.30173343522373e-18 HIF-1 signaling pathway: PDK1 hsa05231__39 8.28224232106147e-19 UP 8.85677515793705 4.48482228278804e-18 Choline metabolism in cancer: EIF4EBP1 hsa04014__54 8.75642698885604e-19 DOWN -8.85056380008731 4.72796733105187e-18 Ras signaling pathway: RHOA hsa04750__59 8.8544327479145e-19 DOWN -8.84932152851737 4.76718599808921e-18 Inflammatory mediator regulation of TRP channels: TRPV2 hsa04024__114 9.25740731164295e-19 DOWN -8.84435244223758 4.96990523959346e-18 cAMP signaling pathway: HHIP hsa05120__19 9.57147546437844e-19 UP 8.84062562752774 5.12387532694219e-18 Epithelial cell signaling in Helicobacter pylori infection: CXCL1 hsa04066__64 9.67848553331993e-19 DOWN -8.83938335595779 5.16644156736027e-18 HIF-1 signaling pathway: LTBR hsa04115__24 9.89606292689651e-19 UP 8.8368988128179 5.26762103105908e-18 p53 signaling pathway: SERPINB5 hsa04115__17 1.03458121202484e-18 UP 8.83192972653811 5.47599464054835e-18 p53 signaling pathway: TP73 hsa05161__66 67 1.03458121202484e-18 DOWN -8.83192972653811 5.47599464054835e-18 Hepatitis B: NFKB1 NFKBIA hsa05205__195 1.08157373156598e-18 DOWN -8.82696064025832 5.70864337531595e-18 Proteoglycans in cancer: CDKN1A hsa04962__22 1.09364749176051e-18 DOWN -8.82571836868838 5.75620066391595e-18 Vasopressin-regulated water reabsorption: ARHGDIA hsa05205__270 1.19515261050776e-18 DOWN -8.8157801961288 6.27288199760916e-18 Proteoglycans in cancer: MAPK1**** hsa04390__75 1.36509509373284e-18 UP 8.80087293728944 7.12503800312222e-18 Hippo signaling pathway: NKD1 hsa04911__25 1.36509509373284e-18 DOWN -8.80087293728944 7.12503800312222e-18 Insulin secretion: PRKCA hsa05231__34 1.39565119620086e-18 DOWN -8.79838839414954 7.26434514587648e-18 Choline metabolism in cancer: PLD1 hsa05205__434 1.4111815574332e-18 DOWN -8.79714612257959 7.32488990722924e-18 Proteoglycans in cancer: CASP3 hsa05020__48 1.42688256000955e-18 DOWN -8.79590385100965 7.38598438087587e-18 Prion diseases: SOD1 hsa04913__40 1.45880391075461e-18 DOWN -8.79341930786975 7.53047403381293e-18 Ovarian steroidogenesis: HSD17B1 hsa04722__85 1.54172549326457e-18 DOWN -8.78720795002002 7.91503333837195e-18 Neurotrophin signaling pathway: BAX hsa04750__40 1.54172549326457e-18 DOWN -8.78720795002002 7.91503333837195e-18 Inflammatory mediator regulation of TRP channels: C00219 hsa05205__422 1.64734881439636e-18 DOWN -8.77975432060034 8.41155571968982e-18 Proteoglycans in cancer: CD63 hsa04950__13 1.64739356298342e-18 DOWN -8.77975432060034 8.41155571968982e-18 Maturity onset diabetes of the young: INS hsa04668__120 1.70287818252773e-18 UP 8.7760275058905 8.67129567742439e-18 TNF signaling pathway: DNM1L hsa04152__58 1.77973742728449e-18 UP 8.77105841961071 9.03818006991231e-18 AMPK signaling pathway: SCD hsa05110__51 1.79947698435416e-18 UP 8.76981614804076 9.11379313639208e-18 Vibrio cholerae infection: PDIA4 hsa04914__42 1.83962052129018e-18 DOWN -8.76733160490087 9.29206171909746e-18 Progesterone-mediated oocyte maturation: ARAF hsa04932__31 133 1.88062035314404e-18 DOWN -8.76484706176097 9.4736880524334e-18 Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA hsa03320__9 1.9225695454381e-18 DOWN -8.76236251862108 9.6591127697278e-18 PPAR signaling pathway: PCK1 hsa04012__21 1.96541828630269e-18 UP 8.75987797548119 9.84805589323399e-18 ErbB signaling pathway: GSK3B hsa04540__14 31 2.00920975414057e-18 DOWN -8.75739343234129 1.00407051277397e-17 Gap junction: GJA1 TJP1 hsa04930__9 2.07667376839428e-18 UP 8.75366661763145 1.03503183310686e-17 Type II diabetes mellitus: C00238 hsa05210__31 2.17020330713515e-18 DOWN -8.74869753135166 1.07878624711824e-17 Colorectal cancer: BCL2 hsa04540__14 16 2.21849670886822e-18 DOWN -8.74621298821177 1.096988241043e-17 Gap junction: GJA1 GJA1 hsa04540__14 15 2.21849670886822e-18 DOWN -8.74621298821177 1.096988241043e-17 Gap junction: GJA1 GJA1* hsa04724__51 2.34392182007439e-18 UP 8.74000163036203 1.15596564302356e-17 Glutamatergic synapse: ADRBK1 hsa04261__62 2.53135690208261e-18 DOWN -8.73130572937241 1.24513602591969e-17 Adrenergic signaling in cardiomyocytes: BCL2 hsa05210__40 2.6742252881752e-18 DOWN -8.72509437152267 1.31197632284104e-17 Colorectal cancer: CASP9 hsa04210__59 2.70374000559987e-18 UP 8.72385209995272 1.32300194544848e-17 Apoptosis: PMAIP1 hsa04723__9 2.85620697539714e-18 DOWN -8.71764074210299 1.3867733609228e-17 Retrograde endocannabinoid signaling: PRKCA hsa04725__20 2.85620697539714e-18 DOWN -8.71764074210299 1.3867733609228e-17 Cholinergic synapse: PRKCA hsa04726__18 2.85620697539714e-18 DOWN -8.71764074210299 1.3867733609228e-17 Serotonergic synapse: PRKCA hsa04068__96 2.88770376454122e-18 DOWN -8.71639847053304 1.39845241586932e-17 FoxO signaling pathway: CCNG2 hsa05222__34 2.98426618292441e-18 UP 8.7126716558232 1.4415002976131e-17 Small cell lung cancer: CCND1 hsa04261__52 3.01715674643595e-18 DOWN -8.71142938425325 1.45365064783414e-17 Adrenergic signaling in cardiomyocytes: MAPK14 hsa04020__42 3.25762841951427e-18 DOWN -8.70273348326362 1.56150096945595e-17 Calcium signaling pathway: MYLK4 hsa04950__8 3.25762841951427e-18 DOWN -8.70273348326362 1.56150096945595e-17 Maturity onset diabetes of the young: NEUROD1 hsa04068__59 3.59478472742907e-18 DOWN -8.6915530391341 1.71872786331787e-17 FoxO signaling pathway: S1PR1 hsa04261__34 4.28132734832939e-18 DOWN -8.67167669401495 2.04178022525658e-17 Adrenergic signaling in cardiomyocytes: AKT3 hsa05222__44 4.57087480450955e-18 UP 8.66422306459527 2.17434778675277e-17 Small cell lung cancer: RB1 hsa04152__68 4.67162163524956e-18 DOWN -8.66173852145537 2.21666087187725e-17 AMPK signaling pathway: PPARGC1A** hsa04068__88 4.87973668475815e-18 DOWN -8.65676943517559 2.30957814374322e-17 FoxO signaling pathway: FBXO32 hsa04810__48 4.98719993715377e-18 DOWN -8.65428489203569 2.35450971907335e-17 Regulation of actin cytoskeleton: IQGAP2 hsa04068__52 5.09699870868881e-18 DOWN -8.6518003488958 2.40031593323967e-17 FoxO signaling pathway: CAT hsa04370__38 5.32380413024787e-18 DOWN -8.64683126261601 2.50085699018394e-17 VEGF signaling pathway: BAD hsa04950__5 5.87117904369116e-18 DOWN -8.63565081848649 2.75110858431314e-17 Maturity onset diabetes of the young: GCK hsa05205__69 6.33499602560326e-18 DOWN -8.62695491749686 2.96105908758918e-17 Proteoglycans in cancer: MAPK1* hsa04914__23 6.54467802036638e-18 DOWN -8.62322810278702 3.05147642686561e-17 Progesterone-mediated oocyte maturation: PRKACA hsa05169__29 6.90947334577972e-18 DOWN -8.61701674493728 3.21358921205943e-17 Epstein-Barr virus infection: FCER2 hsa04068__13 7.78415287267429e-18 DOWN -8.60335175766786 3.61146253030988e-17 FoxO signaling pathway: PCK1 hsa03320__39 7.95453555314089e-18 UP 8.60086721452797 3.68142174984033e-17 PPAR signaling pathway: MMP1 hsa05211__49 8.48807788994549e-18 DOWN -8.59341358510829 3.91869738457189e-17 Renal cell carcinoma: TGFA* hsa04933__59 8.58037221707488e-18 UP 8.59217131353834 3.95159789114797e-17 AGE-RAGE signaling pathway in diabetic complications: SERPINE1 hsa04152__27 8.76794236132224e-18 DOWN -8.58968677039845 4.02810848335562e-17 AMPK signaling pathway: ADIPOR1 hsa04919__91 9.66333285754658e-18 DOWN -8.57850632626893 4.42863474130001e-17 Thyroid hormone signaling pathway: PFKP hsa04930__15 9.98139964902135e-18 DOWN -8.57477951155908 4.56327249160854e-17 Type II diabetes mellitus: C00031* hsa04932__35 1.01991615999599e-17 DOWN -8.57229496841919 4.65151083648659e-17 Non-alcoholic fatty liver disease (NAFLD): PRKAG2 hsa05120__53 1.06488470216607e-17 DOWN -8.5673258821394 4.84483863285723e-17 Epithelial cell signaling in Helicobacter pylori infection: GIT1 hsa04924__52 1.14833555556298e-17 DOWN -8.55862998114977 5.21189011812281e-17 Renin secretion: KCNJ2 hsa04810__30 1.18604605445622e-17 DOWN -8.55490316643993 5.37007358150176e-17 Regulation of actin cytoskeleton: VCL* hsa05200__96 1.22497813985587e-17 DOWN -8.55117635173009 5.5330142422817e-17 Pathways in cancer: C00416 hsa04380__51 1.39372126250194e-17 DOWN -8.53626909289073 6.28010132431929e-17 Osteoclast differentiation: FOS* hsa04915__58 1.56844456981452e-17 DOWN -8.52260410562131 7.05049604469257e-17 Estrogen signaling pathway: CREB3*** hsa04068__43 1.58536120882946e-17 DOWN -8.52136183405136 7.10953153076504e-17 FoxO signaling pathway: CDKN1A hsa04064__134 1.65484690107902e-17 DOWN -8.51639274777158 7.40346982649398e-17 NF-kappa B signaling pathway: CCL21 hsa04931__35 1.72733601380413e-17 DOWN -8.51142366149179 7.7094165556721e-17 Insulin resistance: C00369 hsa04022__19 1.76474663046572e-17 DOWN -8.50893911835189 7.8391463797756e-17 cGMP-PKG signaling pathway: CNGB1 hsa04261__8 38 1.76474663046572e-17 DOWN -8.50893911835189 7.8391463797756e-17 Adrenergic signaling in cardiomyocytes: ATP2A2 PLN hsa04664__25 1.78375061395925e-17 DOWN -8.50769684678195 7.90487595195622e-17 Fc epsilon RI signaling pathway: MAPK14 hsa04071__24 1.80295649836775e-17 DOWN -8.506454575212 7.93385306892975e-17 Sphingolipid signaling pathway: PTEN hsa04530__20 62 1.80295649836775e-17 DOWN -8.506454575212 7.93385306892975e-17 Tight junction: ACTB SHROOM1 hsa05231__17 1.80295649836775e-17 DOWN -8.506454575212 7.93385306892975e-17 Choline metabolism in cancer: SLC44A3 hsa03320__29 1.94323135991681e-17 UP 8.49775867422237 8.53114889084973e-17 PPAR signaling pathway: OLR1 hsa04810__8 79 2.09426364097202e-17 DOWN -8.48906277323274 9.15144507299171e-17 Regulation of actin cytoskeleton: ARPC5 ACTB hsa04810__8 82 2.09426364097202e-17 DOWN -8.48906277323274 9.15144507299171e-17 Regulation of actin cytoskeleton: ARPC5 ACTB* hsa03320__23 2.23289631851148e-17 DOWN -8.48160914381306 9.73459903128323e-17 PPAR signaling pathway: ACADL hsa04728__44 2.3805754185488e-17 DOWN -8.47415551439338 1.03544009524379e-16 Dopaminergic synapse: FOS hsa03320__10 2.56507929059013e-17 DOWN -8.46545961340375 1.11311408476186e-16 PPAR signaling pathway: PLIN1 hsa04520__64 2.5925635589342e-17 DOWN -8.4642173418338 1.12244860074593e-16 Adherens junction: CTNND1** hsa04910__39 2.79325904657181e-17 DOWN -8.45552144084417 1.20655948241573e-16 Insulin signaling pathway: BAD hsa04920__16 2.9147448693403e-17 DOWN -8.45055235456439 1.2561480755712e-16 Adipocytokine signaling pathway: POMC hsa05110__14 3.04139854830241e-17 UP 8.4455832682846 1.30177400279276e-16 Vibrio cholerae infection: C00238* hsa05110__15 3.04139854830241e-17 UP 8.4455832682846 1.30177400279276e-16 Vibrio cholerae infection: C01330 hsa05110__16 3.04139854830241e-17 UP 8.4455832682846 1.30177400279276e-16 Vibrio cholerae infection: C00698 hsa04742__18 3.38243809603285e-17 DOWN -8.43316055258513 1.44445481419221e-16 Taste transduction: PDE1A hsa04670__76 3.49190264001563e-17 DOWN -8.42943373787529 1.48781974163024e-16 Leukocyte transendothelial migration: CDC42 hsa04728__32 3.84169792847783e-17 DOWN -8.41825329374576 1.63315620081671e-16 Dopaminergic synapse: CREB3 hsa05130__55 4.05073655125469e-17 DOWN -8.41204193589603 1.71813408122067e-16 Pathogenic Escherichia coli infection: ACTB hsa04014__38 4.18150415216182e-17 DOWN -8.40831512118619 1.76960502295317e-16 Ras signaling pathway: MAPK8 hsa04024__12 4.50304160661156e-17 DOWN -8.39961922019656 1.90139666939845e-16 cAMP signaling pathway: SLC9A1 hsa04024__116 4.84894185412569e-17 DOWN -8.39092331920693 2.04286137755654e-16 cAMP signaling pathway: ACOX1 hsa05215__43 5.56213699311077e-17 DOWN -8.37477378879762 2.33808845862531e-16 Prostate cancer: C05981 hsa04014__63 5.68082549806221e-17 DOWN -8.37228924565773 2.382649801531e-16 Ras signaling pathway: TIAM1* hsa04115__38 6.24595285497477e-17 UP 8.3611088015282 2.61384084955403e-16 p53 signaling pathway: GTSE1 hsa04919__31 6.37887584781146e-17 DOWN -8.35862425838831 2.66353504845283e-16 Thyroid hormone signaling pathway: ATP2A2 hsa04933__30 6.6531468387601e-17 UP 8.35365517210852 2.77189864967411e-16 AGE-RAGE signaling pathway in diabetic complications: CXCL8 hsa04064__3 6.72351216622407e-17 DOWN -8.35241290053857 2.79501755759624e-16 NF-kappa B signaling pathway: BCL2 hsa04810__29 6.93904152043618e-17 DOWN -8.34868608582873 2.87824702359814e-16 Regulation of actin cytoskeleton: ACTN4 hsa05200__202 7.23704515017576e-17 UP 8.34371699954894 2.99524401700006e-16 Pathways in cancer: FIGF* hsa05213__27 7.39074489461251e-17 DOWN -8.34123245640905 3.05213399054437e-16 Endometrial cancer: ELK1 hsa05220__15 8.03839751057993e-17 UP 8.33129428384948 3.31231336017098e-16 Chronic myeloid leukemia: MYC hsa04950__22 8.1231909332674e-17 UP 8.33005201227953 3.33992905111804e-16 Maturity onset diabetes of the young: NR5A2 hsa05217__19 8.20886630366028e-17 DOWN -8.32880974070958 3.36778597916543e-16 Basal cell carcinoma: HHIP hsa04110__10 11 12 13 14 9 15 16 17 18 19 20 8.47127495483093e-17 UP 8.32508292599974 3.46787050983166e-16 Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 hsa05215__12 8.56056942966081e-17 DOWN -8.32384065442979 3.49680651268101e-16 Prostate cancer: KLK3 hsa04666__41 9.11616174929314e-17 UP 8.31638702501011 3.71567633989627e-16 Fc gamma R-mediated phagocytosis: MARCKS hsa04024__34 9.50615830504153e-17 DOWN -8.31141793873032 3.85789880241318e-16 cAMP signaling pathway: ATP2B1 hsa04976__16 9.50615830504153e-17 DOWN -8.31141793873032 3.85789880241318e-16 Bile secretion: CFTR hsa04012__8 1.00168561879752e-16 DOWN -8.30520658088059 4.0476715649904e-16 ErbB signaling pathway: STAT5A hsa05215__39 1.00168561879752e-16 UP 8.30520658088059 4.0476715649904e-16 Prostate cancer: RB1 hsa04360__29 1.02286276261077e-16 UP 8.30272203774069 4.12437581747991e-16 Axon guidance: RASA1 hsa04115__30 1.03361628067863e-16 UP 8.30147976617075 4.15881154474336e-16 p53 signaling pathway: SERPINE1 hsa04550__25 1.13555282535856e-16 DOWN -8.29029932204122 4.5591960659161e-16 Signaling pathways regulating pluripotency of stem cells: MAPK1 hsa04740__21 1.19640310885313e-16 DOWN -8.28408796419149 4.7932653337634e-16 Olfactory transduction: PDE1A hsa04064__54 1.3141417704166e-16 DOWN -8.27290752006197 5.25377103534635e-16 NF-kappa B signaling pathway: CCL13 hsa04923__31 1.32790902744647e-16 DOWN -8.27166524849202 5.2975394109807e-16 Regulation of lipolysis in adipocytes: PRKACA* hsa03320__63 1.34181847063479e-16 DOWN -8.27042297692207 5.34168836085334e-16 PPAR signaling pathway: DBI hsa04750__90 1.37006971714112e-16 DOWN -8.26793843378218 5.44262367549295e-16 Inflammatory mediator regulation of TRP channels: C01245** hsa05010__51 1.53625868277799e-16 UP 8.25427344651276 6.08993684586466e-16 Alzheimer's disease: ATF6 hsa05030__77 1.58493306273611e-16 DOWN -8.25054663180292 6.2696615260656e-16 Cocaine addiction: BDNF hsa04151__99 1.61822411650791e-16 UP 8.24806208866303 6.38790570361002e-16 PI3K-Akt signaling pathway: MYB hsa04730__7 1.7222890243635e-16 DOWN -8.24060845924334 6.78444670184281e-16 Long-term depression: GNA13 hsa04024__108 1.91058084186028e-16 UP 8.22818574354388 7.51042134279387e-16 cAMP signaling pathway: AMH hsa03320__45 1.97092610760151e-16 DOWN -8.22445892883403 7.71535449204839e-16 PPAR signaling pathway: PDPK1 hsa04931__124 1.97092610760151e-16 DOWN -8.22445892883403 7.71535449204839e-16 Insulin resistance: FOXO1* hsa04270__10 3 71 2.05431790821943e-16 DOWN -8.21948984255425 8.02507972878233e-16 Vascular smooth muscle contraction: ACTA2 MYL9 MYH11 hsa04390__76 2.07570354375143e-16 UP 8.2182475709843 8.09179866952063e-16 Hippo signaling pathway: MYC hsa04650__35 2.18596791961626e-16 UP 8.21203621313456 8.50400356306201e-16 Natural killer cell mediated cytotoxicity: BID hsa05231__59 2.47471193760247e-16 DOWN -8.1971289542952 9.60740440238645e-16 Choline metabolism in cancer: PLA2G4B hsa05145__67 2.50040540434376e-16 DOWN -8.19588668272525 9.6672052567118e-16 Toxoplasmosis: BAD hsa05212__8 2.50040540434376e-16 DOWN -8.19588668272525 9.6672052567118e-16 Pancreatic cancer: NFKB1 hsa05161__57 2.66018108388813e-16 DOWN -8.18843305330557 1.02638198288004e-15 Hepatitis B: STAT3* hsa05222__40 2.88896233606346e-16 UP 8.17849488074599 1.11236889948017e-15 Small cell lung cancer: TRAF1 hsa04520__17 3.10498153232047e-16 UP 8.16979897975637 1.19310026569124e-15 Adherens junction: SNAI1 hsa04723__46 3.33690447882862e-16 UP 8.16110307876674 1.27960071749367e-15 Retrograde endocannabinoid signaling: ADCY1 hsa04014__97 3.44145116987916e-16 DOWN -8.1573762640569 1.314326574838e-15 Ras signaling pathway: PAK4 hsa04390__14 3.44145116987916e-16 UP 8.1573762640569 1.314326574838e-15 Hippo signaling pathway: AREG hsa05152__78 3.54922474026502e-16 UP 8.15364944934706 1.35273697504218e-15 Tuberculosis: IL1A hsa05164__99 3.66032324595536e-16 UP 8.14992263463721 1.39225655448383e-15 Influenza A: FDPS hsa04152__94 4.68158399435249e-16 DOWN -8.12010811695849 1.77352748495732e-15 AMPK signaling pathway: MLYCD hsa04360__4 4.68158399435249e-16 DOWN -8.12010811695849 1.77352748495732e-15 Axon guidance: GNAI1* hsa05205__215 216 4.72974379283754e-16 DOWN -8.11886584538854 1.78816671765427e-15 Proteoglycans in cancer: EIF4B RPS6 hsa05161__31 5.08080685203982e-16 DOWN -8.11016994439891 1.91703535642225e-15 Hepatitis B: ELK1 hsa05200__188 5.13301099780186e-16 DOWN -8.10892767282896 1.93285123544483e-15 Pathways in cancer: KLK3 hsa03320__58 5.29281552803344e-16 DOWN -8.10520085811912 1.98904007543497e-15 PPAR signaling pathway: CYP8B1 hsa05213__12 5.40206528858875e-16 DOWN -8.10271631497923 2.02604404735694e-15 Endometrial cancer: BAD hsa04020__8 5.80222760551934e-16 DOWN -8.0940204139896 2.17178997425714e-15 Calcium signaling pathway: PDE1A hsa04916__10 6.16836919210884e-16 DOWN -8.08656678456992 2.29967573650248e-15 Melanogenesis: CAMK2A hsa05221__27 6.16836919210884e-16 DOWN -8.08656678456992 2.29967573650248e-15 Acute myeloid leukemia: PIM2 hsa04742__37 6.29517945886307e-16 DOWN -8.08408224143002 2.34230538677301e-15 Taste transduction: P2RY4 hsa04340__15 7.3339627976118e-16 DOWN -8.06544816788082 2.71805051217211e-15 Hedgehog signaling pathway: HHIP hsa05132__20 7.3339627976118e-16 DOWN -8.06544816788082 2.71805051217211e-15 Salmonella infection: ACTB hsa04750__60 7.40874160488725e-16 DOWN -8.06420589631087 2.74035934558723e-15 Inflammatory mediator regulation of TRP channels: TRPV3 hsa05200__205 7.56108083616467e-16 UP 8.06172135317098 2.79121235582582e-15 Pathways in cancer: SLC2A1 hsa04520__18 8.03630475842247e-16 DOWN -8.0542677237513 2.96082679236781e-15 Adherens junction: SNAI2 hsa04062__35 36 37 8.45470888496048e-16 DOWN -8.04805636590156 3.10888414771835e-15 Chemokine signaling pathway: PARD3 PRKCZ TIAM1 hsa04933__35 8.89455860123619e-16 UP 8.04184500805183 3.25787048961458e-15 AGE-RAGE signaling pathway in diabetic complications: CCND1 hsa05211__3 8.89455860123619e-16 UP 8.04184500805183 3.25787048961458e-15 Renal cell carcinoma: VEGFA hsa04068__49 9.26260409866365e-16 DOWN -8.03687592177204 3.38607647886945e-15 FoxO signaling pathway: BCL2L11 hsa05211__22 9.35693527639718e-16 DOWN -8.03563365020209 3.41391871540783e-15 Renal cell carcinoma: TGFA hsa05014__33 34 9.45221275142598e-16 DOWN -8.03439137863214 3.4419976278933e-15 Amyotrophic lateral sclerosis (ALS): NEFH PRPH hsa04014__41 9.94312483529988e-16 DOWN -8.02818002078241 3.60678215550743e-15 Ras signaling pathway: RAC1* hsa04530__30 9.94312483529988e-16 UP 8.02818002078241 3.60678215550743e-15 Tight junction: AKT3 hsa03320__36 1.04591352439635e-15 DOWN -8.02196866293268 3.78665031279525e-15 PPAR signaling pathway: SLC27A4 hsa04620__40 1.08908605235889e-15 DOWN -8.01699957665289 3.93537056227375e-15 Toll-like receptor signaling pathway: CCL5 hsa05160__53 1.19274605086436e-15 UP 8.00581913252336 4.2934287922876e-15 Hepatitis C: EIF2S1 hsa05162__74 1.19274605086436e-15 UP 8.00581913252336 4.2934287922876e-15 Measles: EIF2S1 hsa04068__67 1.22941363727326e-15 DOWN -8.00209231781352 4.41695645207736e-15 FoxO signaling pathway: GABARAP hsa04810__23 1.2671911160941e-15 DOWN -7.99836550310368 4.5439925708794e-15 Regulation of actin cytoskeleton: GSN hsa04010__13 1.35984230878547e-15 UP 7.98966960211405 4.86694037753887e-15 MAPK signaling pathway: STMN1 hsa04722__50 1.41574899385883e-15 UP 7.98470051583427 5.05739992292917e-15 Neurotrophin signaling pathway: RHOA hsa04152__30 1.47391827852483e-15 UP 7.97973142955448 5.24525084346241e-15 AMPK signaling pathway: ACACA hsa05161__48 1.47391827852483e-15 DOWN -7.97973142955448 5.24525084346241e-15 Hepatitis B: STAT1 hsa05221__29 1.51908412764529e-15 DOWN -7.97600461484464 5.3957638484792e-15 Acute myeloid leukemia: RPS6KB1 hsa04620__87 1.64629838206876e-15 DOWN -7.96606644228506 5.83659369793811e-15 Toll-like receptor signaling pathway: CCL4L1 hsa04630__24 1.73107660490953e-15 UP 7.95985508443532 6.12559875823918e-15 Jak-STAT signaling pathway: MCL1 hsa04062__42 1.74854113047826e-15 DOWN -7.95861281286538 6.17576839129447e-15 Chemokine signaling pathway: PAK1 hsa05160__85 1.78399240883558e-15 DOWN -7.95612826972548 6.2891589797412e-15 Hepatitis C: BAD hsa04530__5 10 1.80198257060517e-15 DOWN -7.95488599815554 6.34068398907698e-15 Tight junction: IGSF5 MAGI1 hsa04151__51 1.82015138075508e-15 UP 7.95364372658559 6.39264382138092e-15 PI3K-Akt signaling pathway: NOS3 hsa04270__24 2.26878174967281e-15 DOWN -7.92631375204676 7.95343452917017e-15 Vascular smooth muscle contraction: ACTA2 hsa04666__30 44 2.29157698748286e-15 DOWN -7.92507148047681 8.01838577184413e-15 Fc gamma R-mediated phagocytosis: C04637 GSN hsa04664__30 2.40898007104407e-15 DOWN -7.91886012262707 8.41351961615579e-15 Fc epsilon RI signaling pathway: PRKCA hsa04915__3 11 2.68851429513164e-15 DOWN -7.90519513535766 9.33774188641839e-15 Estrogen signaling pathway: ESR1 C00951 hsa04915__12 14 2.68851429513164e-15 DOWN -7.90519513535766 9.33774188641839e-15 Estrogen signaling pathway: ESR1 FOS hsa04915__12 13 2.68851429513164e-15 DOWN -7.90519513535766 9.33774188641839e-15 Estrogen signaling pathway: ESR1 C00951* hsa04921__11 2.85420704835422e-15 UP 7.89774150593798 9.89493550527228e-15 Oxytocin signaling pathway: PRKACA hsa04115__20 2.94078396138206e-15 UP 7.89401469122813 1.017630398423e-14 p53 signaling pathway: RRM2B hsa04360__3 3.21632851812584e-15 DOWN -7.88283424709861 1.1109340598453e-14 Axon guidance: GNAI1 hsa05222__39 3.31370829667711e-15 UP 7.87910743238877 1.14246933751492e-14 Small cell lung cancer: BCL2L1 hsa04151__102 3.38023496039552e-15 DOWN -7.87662288924888 1.16327133527165e-14 PI3K-Akt signaling pathway: C8orf44-SGK3 hsa04151__36 3.55235915865056e-15 DOWN -7.87041153139914 1.2202710894158e-14 PI3K-Akt signaling pathway: PCK1 hsa04062__33 3.58780543311604e-15 DOWN -7.86916925982919 1.2279574515164e-14 Chemokine signaling pathway: WAS hsa04724__26 3.58780543311604e-15 DOWN -7.86916925982919 1.2279574515164e-14 Glutamatergic synapse: PRKACA hsa03320__60 3.73310615194855e-15 DOWN -7.86420017354941 1.27536481082024e-14 PPAR signaling pathway: CYP27A1 hsa04390__95 3.84586909979393e-15 UP 7.86047335883957 1.30912826784652e-14 Hippo signaling pathway: AFP hsa04924__49 3.84586909979393e-15 DOWN -7.86047335883957 1.30912826784652e-14 Renin secretion: PDE1A hsa04380__32 4.87723675162954e-15 DOWN -7.83065884116084 1.65720214399854e-14 Osteoclast differentiation: AKT3 hsa04920__28 5.07380088796531e-15 DOWN -7.82568975488105 1.72087939864383e-14 Adipocytokine signaling pathway: SLC2A1 hsa04550__36 5.17498684336565e-15 DOWN -7.82320521174116 1.74888494220936e-14 Signaling pathways regulating pluripotency of stem cells: AKT3* hsa04921__28 5.17498684336565e-15 DOWN -7.82320521174116 1.74888494220936e-14 Oxytocin signaling pathway: EEF2 hsa04961__5 5.38335459470838e-15 DOWN -7.81823612546137 1.81603649613232e-14 Endocrine and other factor-regulated calcium reabsorption: TRPV5 hsa05020__52 5.54502946094499e-15 DOWN -7.81450931075153 1.86722407833614e-14 Prion diseases: FYN hsa04976__59 5.65545829456313e-15 DOWN -7.81202476761163 1.9010028864909e-14 Bile secretion: ABCB4 hsa04022__71 5.76800601476604e-15 UP 7.80954022447174 1.93537201816882e-14 cGMP-PKG signaling pathway: PPIF hsa03320__55 5.94108979224445e-15 UP 7.8058134097619 1.98989442417599e-14 PPAR signaling pathway: SCD hsa05212__19 5.99989704444654e-15 DOWN -7.80457113819195 2.00601539973577e-14 Pancreatic cancer: MAPK8 hsa04071__59 60 6.30263715133535e-15 DOWN -7.79835978034222 2.10349115583643e-14 Sphingolipid signaling pathway: TP53 BCL2 hsa04530__11 62 6.36496509002402e-15 DOWN -7.79711750877227 2.12052649009843e-14 Tight junction: TJP1 SHROOM1 hsa04933__19 6.68582074275089e-15 DOWN -7.79090615092253 2.22347914612901e-14 AGE-RAGE signaling pathway in diabetic complications: TGFBR2 hsa04919__100 6.75187647528482e-15 DOWN -7.78966387935259 2.24147984047e-14 Thyroid hormone signaling pathway: CTNNB1* hsa04020__7 7.16191538524211e-15 UP 7.78221024993291 2.37341075994179e-14 Calcium signaling pathway: ADCY1 hsa04931__104 7.67134116295257e-15 DOWN -7.77351434894328 2.53775528964575e-14 Insulin resistance: C00369* hsa05134__73 7.97828250432406e-15 UP 7.76854526266349 2.63465603262301e-14 Legionellosis: CXCL1 hsa04115__54 8.21639035390079e-15 UP 7.76481844795365 2.70852587280344e-14 p53 signaling pathway: PERP hsa05160__58 8.62887051890195e-15 UP 7.75860709010391 2.83951798686809e-14 Hepatitis C: EIF3E hsa05166__132 136 9.33160291564903e-15 UP 7.74866891754434 3.06539892980848e-14 HTLV-I infection: CREBBP TP53 hsa04919__44 9.51590777113941e-15 DOWN -7.74618437440444 3.12048703350278e-14 Thyroid hormone signaling pathway: PFKFB2 hsa04360__40 142 9.79910102236301e-15 DOWN -7.7424575596946 3.20775449843556e-14 Axon guidance: UNC5D PTPN11 hsa04012__23 1.00905840813975e-14 DOWN -7.73873074498476 3.29742738938189e-14 ErbB signaling pathway: RPS6KB1 hsa04933__57 1.03905954456925e-14 UP 7.73500393027492 3.38957097959308e-14 AGE-RAGE signaling pathway in diabetic complications: FIGF hsa04972__23 1.04925366014062e-14 DOWN -7.73376165870497 3.416893635016e-14 Pancreatic secretion: KCNMA1 hsa04151__110 1.44687870149113e-14 DOWN -7.69276669689672 4.70360740502046e-14 PI3K-Akt signaling pathway: BCL2** hsa04310__36 1.48964574083747e-14 UP 7.68903988218688 4.81763226683926e-14 Wnt signaling pathway: MYC hsa04630__27 1.48964574083747e-14 UP 7.68903988218688 4.81763226683926e-14 Jak-STAT signaling pathway: PIM1 hsa04722__37 1.48964574083747e-14 UP 7.68903988218688 4.81763226683926e-14 Neurotrophin signaling pathway: NFKB1 hsa04024__31 1.50417594094326e-14 DOWN -7.68779761061693 4.84793583710531e-14 cAMP signaling pathway: C00165 hsa04024__32 1.50417594094326e-14 DOWN -7.68779761061693 4.84793583710531e-14 cAMP signaling pathway: C01245 hsa04722__84 1.54860834314448e-14 DOWN -7.68407079590709 4.98259430953507e-14 Neurotrophin signaling pathway: NFKB1* hsa04370__23 1.56370416833586e-14 UP 7.68282852433715 5.0225643287232e-14 VEGF signaling pathway: PTK2 hsa05162__58 1.57894474845063e-14 DOWN -7.6815862527672 5.06286208590229e-14 Measles: STAT3 hsa04550__22 1.60986564335651e-14 UP 7.67910170962731 5.153215577286e-14 Signaling pathways regulating pluripotency of stem cells: SMAD2 hsa05016__60 1.64138209463608e-14 DOWN -7.67661716648741 5.23625968730254e-14 Huntington's disease: CASP3* hsa05134__35 1.64138209463608e-14 DOWN -7.67661716648741 5.23625968730254e-14 Legionellosis: CASP3 hsa04530__5 15 1.65736716843499e-14 DOWN -7.67537489491747 5.27829306693109e-14 Tight junction: IGSF5 MPDZ hsa04270__28 1.68979815553397e-14 DOWN -7.67289035177757 5.36339651055461e-14 Vascular smooth muscle contraction: KCNMB2 hsa04810__35 81 80 1.68979815553397e-14 DOWN -7.67289035177757 5.36339651055461e-14 Regulation of actin cytoskeleton: MYL12B MYH9 ACTB hsa04921__54 1.80829964675586e-14 UP 7.66419445078794 5.72983985877615e-14 Oxytocin signaling pathway: RCAN1 hsa05014__13 1.86155444407576e-14 DOWN -7.6604676360781 5.88865454615884e-14 Amyotrophic lateral sclerosis (ALS): CASP3 hsa04152__52 1.87964660379849e-14 DOWN -7.65922536450815 5.93589238409641e-14 AMPK signaling pathway: PCK1 hsa04360__89 1.93496730591731e-14 UP 7.65549854979831 6.10034155674266e-14 Axon guidance: CAMK2A hsa04380__48 2.05045702111636e-14 DOWN -7.64804492037863 6.45361598438467e-14 Osteoclast differentiation: NFATC1 hsa04210__107 2.30214933663438e-14 DOWN -7.63313766153927 7.2336765945418e-14 Apoptosis: MCL1 hsa04916__4 2.34695480057812e-14 DOWN -7.63065311839937 7.36215036775675e-14 Melanogenesis: TYR hsa04066__50 2.39261774975141e-14 DOWN -7.62816857525948 7.4928812529715e-14 HIF-1 signaling pathway: TF hsa05200__212 2.46275530914847e-14 UP 7.62444176054964 7.6996958833444e-14 Pathways in cancer: CCND1*** hsa05205__284 2.51063316303299e-14 DOWN -7.62195721740974 7.83634503876909e-14 Proteoglycans in cancer: PRKCA* hsa05164__53 2.60915175025863e-14 DOWN -7.61698813112996 8.13034185528353e-14 Influenza A: MAPK14 hsa04750__44 2.65980237728621e-14 DOWN -7.61450358799006 8.26077465606742e-14 Inflammatory mediator regulation of TRP channels: TRPA1 hsa04750__63 2.65980237728621e-14 DOWN -7.61450358799006 8.26077465606742e-14 Inflammatory mediator regulation of TRP channels: TRPA1* hsa05200__207 2.90010769890339e-14 UP 7.60332314386054 8.99224812910803e-14 Pathways in cancer: CDK4 hsa04920__10 3.07202617533745e-14 DOWN -7.59586951444086 9.50961644721428e-14 Adipocytokine signaling pathway: PCK1 hsa05012__57 3.10163770288417e-14 DOWN -7.59462724287091 9.58548888769631e-14 Parkinson's disease: CASP3 hsa04610__46 3.19216679373132e-14 UP 7.59090042816107 9.84906634716117e-14 Complement and coagulation cascades: C2 hsa04014__79 3.3169252542064e-14 DOWN -7.58593134188128 1.02172172994325e-13 Ras signaling pathway: RAC1** hsa04950__15 3.41362916850035e-14 DOWN -7.58220452717144 1.04978874101672e-13 Maturity onset diabetes of the young: IAPP hsa04670__55 3.5468921284338e-14 DOWN -7.57723544089165 1.08898861263515e-13 Leukocyte transendothelial migration: RAC2 hsa05222__19 4.41850249632157e-14 DOWN -7.54866319478287 1.35438273908454e-13 Small cell lung cancer: CASP9 hsa03320__59 4.46083536690802e-14 DOWN -7.54742092321293 1.36291213893011e-13 PPAR signaling pathway: NR1H3 hsa04064__135 4.46083536690802e-14 DOWN -7.54742092321293 1.36291213893011e-13 NF-kappa B signaling pathway: CCL19 hsa04020__64 4.67855517384456e-14 DOWN -7.54120956536319 1.42479824500064e-13 Calcium signaling pathway: C01330* hsa04020__12 4.67855517384456e-14 DOWN -7.54120956536319 1.42479824500064e-13 Calcium signaling pathway: C01330 hsa04110__48 4.8141672845258e-14 UP 7.53748275065335 1.46372497210744e-13 Cell cycle: RB1* hsa05145__9 5.6588622132884e-14 DOWN -7.51636413396425 1.71777093679627e-13 Toxoplasmosis: MAPK1 hsa04530__11 36 14 5.87788300528533e-14 DOWN -7.51139504768446 1.78137776885986e-13 Tight junction: TJP1 CTNNB1 CTNNA1 hsa04360__96 6.1052324579334e-14 UP 7.50642596140467 1.84729980490449e-13 Axon guidance: GSK3B hsa04010__67 6.22212714386337e-14 UP 7.50394141826478 1.87964258895808e-13 MAPK signaling pathway: ELK1 hsa05205__103 6.58617226557894e-14 UP 7.4964877888451 1.98642338475487e-13 Proteoglycans in cancer: CCND1 hsa05215__24 7.10430773157918e-14 DOWN -7.48654961628552 2.13926189545469e-13 Prostate cancer: CDKN1A hsa04390__59 7.3781975574704e-14 UP 7.48158053000573 2.2181813136779e-13 Hippo signaling pathway: SERPINE1 hsa04662__36 8.66270992109165e-14 DOWN -7.46046191331664 2.60019679580371e-13 B cell receptor signaling pathway: CD79A hsa04730__30 9.25336784625994e-14 DOWN -7.45176601232701 2.77305872139114e-13 Long-term depression: C00025* hsa05152__81 9.60847571413761e-14 DOWN -7.44679692604722 2.87489265395933e-13 Tuberculosis: IFNA1 hsa04066__51 1.11678017214447e-13 DOWN -7.42692058092807 3.33613663507069e-13 HIF-1 signaling pathway: TFRC hsa05200__226 1.15949698792687e-13 DOWN -7.42195149464828 3.45824577827714e-13 Pathways in cancer: CDKN1A* hsa04152__44 1.17042464870799e-13 DOWN -7.42070922307833 3.48530572887846e-13 AMPK signaling pathway: SLC2A4 hsa04010__65 1.19258447298848e-13 UP 7.41822467993844 3.54567440624266e-13 MAPK signaling pathway: ELK4 hsa04211__56 1.2265993884368e-13 DOWN -7.4144978652286 3.6410430503519e-13 Longevity regulating pathway - mammal: CAT hsa05164__70 1.34701327030114e-13 DOWN -7.40207514952913 3.98588651164698e-13 Influenza A: RNASEL hsa05168__83 1.34701327030114e-13 DOWN -7.40207514952913 3.98588651164698e-13 Herpes simplex infection: RNASEL hsa04917__40 1.45164264965925e-13 UP 7.39213697696955 4.28873669608449e-13 Prolactin signaling pathway: TH hsa04920__6 1.52104898599204e-13 DOWN -7.38592561911982 4.48673633387604e-13 Adipocytokine signaling pathway: PTPN11 hsa04066__58 1.57891271494903e-13 DOWN -7.38095653284003 4.65012067615868e-13 HIF-1 signaling pathway: EDN1 hsa04970__39 1.60863614204909e-13 UP 7.37847198970013 4.73024618295813e-13 Salivary secretion: KCNN4 hsa04530__11 33 1.63893789809712e-13 DOWN -7.37598744656024 4.81181923519451e-13 Tight junction: TJP1 CGN hsa04152__56 1.6697856756723e-13 UP 7.37350290342035 4.89473835349183e-13 AMPK signaling pathway: FASN hsa05034__84 1.68542277870352e-13 DOWN -7.3722606318504 4.93288068720235e-13 Alcoholism: FOSB hsa05215__25 1.76579227855996e-13 DOWN -7.36604927400067 5.1600679493222e-13 Prostate cancer: FOXO1 hsa04670__54 1.95609199813364e-13 DOWN -7.35238428673125 5.70729326784644e-13 Leukocyte transendothelial migration: RAC1* hsa04012__57 2.12665906137199e-13 DOWN -7.34120384260173 6.19533701754723e-13 ErbB signaling pathway: ABL1 hsa04742__67 2.29048454576494e-13 DOWN -7.33126567004215 6.6622607763039e-13 Taste transduction: PRKACA hsa05221__13 2.33334066529033e-13 DOWN -7.32878112690226 6.77642520877981e-13 Acute myeloid leukemia: NFKB1 hsa05321__152 2.55972042491317e-13 UP 7.31635841120279 7.42239919508e-13 Inflammatory bowel disease (IBD): FOXP3* hsa04917__75 2.63174617239827e-13 UP 7.31263159649294 7.61949315552595e-13 Prolactin signaling pathway: CCND1** hsa04213__60 2.73088490438579e-13 DOWN -7.30766251021316 7.89435805437062e-13 Longevity regulating pathway - multiple species: CAT hsa04650__25 2.80763744582568e-13 DOWN -7.30393569550332 8.10376460938012e-13 Natural killer cell mediated cytotoxicity: SH2D1B hsa05200__227 3.10762256761372e-13 DOWN -7.2902707082339 8.95586319715671e-13 Pathways in cancer: FOXO1 hsa04922__51 3.34535061911232e-13 DOWN -7.28033253567432 9.62620798363255e-13 Glucagon signaling pathway: G6PC hsa05010__12 3.47082340947227e-13 DOWN -7.27536344939453 9.97198346544097e-13 Alzheimer's disease: CASP3 hsa04015__92 3.53519719275394e-13 UP 7.27287890625464 1.01414282827247e-12 Rap1 signaling pathway: C00076* hsa04913__21 3.56794998201166e-13 DOWN -7.27163663468469 1.02042283351597e-12 Ovarian steroidogenesis: CYP17A1 hsa04913__22 3.56794998201166e-13 DOWN -7.27163663468469 1.02042283351597e-12 Ovarian steroidogenesis: CYP17A1* hsa04620__22 3.63417879431404e-13 DOWN -7.2691520915448 1.03778449156779e-12 Toll-like receptor signaling pathway: CD86 hsa04666__49 3.70161449549844e-13 DOWN -7.26666754840491 1.05543757769978e-12 Fc gamma R-mediated phagocytosis: ARF6* hsa04152__60 3.91138051986724e-13 UP 7.25921391898522 1.11355818133796e-12 AMPK signaling pathway: EEF2 hsa04210__74 3.9474585312534e-13 UP 7.25797164741528 1.12212928596447e-12 Apoptosis: BAX* hsa04068__45 4.05766461323399e-13 DOWN -7.25424483270544 1.15171477466264e-12 FoxO signaling pathway: RBL2 hsa05161__97 4.52950920281406e-13 DOWN -7.23933757386607 1.28370253274323e-12 Hepatitis B: BCL2 hsa04213__54 4.78523285268606e-13 UP 7.23188394444639 1.35413441719836e-12 Longevity regulating pathway - multiple species: SOD2* hsa04540__16 17 5.00912154442961e-13 DOWN -7.22567258659666 1.41535930556139e-12 Gap junction: GJA1 GJA1** hsa05169__32 5.38890974919531e-13 DOWN -7.21573441403708 1.52038459740811e-12 Epstein-Barr virus infection: CR2 hsa04922__78 5.7443151041206e-13 DOWN -7.20703851304745 1.61822609904687e-12 Glucagon signaling pathway: ACACA hsa04620__23 5.85001908935937e-13 DOWN -7.20455396990756 1.64553680672249e-12 Toll-like receptor signaling pathway: CD40 hsa05168__27 6.23523944891712e-13 DOWN -7.19585806891793 1.75127278393352e-12 Herpes simplex infection: IRF3 hsa05164__68 7.27746535930572e-13 UP 7.17473945222883 2.0409488671844e-12 Influenza A: EIF2S1 hsa04724__66 8.04107031376987e-13 DOWN -7.16107446495941 2.2517393620825e-12 Glutamatergic synapse: PLA2G4B hsa05150__1 2 3 8.18811920043341e-13 DOWN -7.15858992181952 2.28950535381166e-12 Staphylococcus aureus infection: CFD C3 CFB hsa04910__43 8.49017902871302e-13 DOWN -7.15362083553973 2.37043780014142e-12 Insulin signaling pathway: G6PC hsa04530__6 11 45 8.56738680146012e-13 DOWN -7.15237856396978 2.3884450741756e-12 Tight junction: CLDN24 TJP1 TJP2 hsa04660__56 9.04531526964855e-13 DOWN -7.1449249345501 2.51794776172883e-12 T cell receptor signaling pathway: CD3E hsa04068__57 9.63603361440529e-13 DOWN -7.13622903356047 2.678418219152e-12 FoxO signaling pathway: IL7R hsa04520__58 9.67386368854413e-13 UP 5.84053978610576 2.68496157618529e-12 Adherens junction: CDH1* hsa04921__57 9.81165492664767e-13 DOWN -7.13374449042058 2.71918873262109e-12 Oxytocin signaling pathway: FOS hsa05200__197 1.04514220263853e-12 UP 7.12504858943095 2.89222709684507e-12 Pathways in cancer: CCND1** hsa04726__71 1.2180479087622e-12 DOWN -7.10392997274185 3.36575297141791e-12 Serotonergic synapse: CACNA1A hsa04530__11 13 1.25134761842406e-12 DOWN -7.10020315803201 3.45269041852981e-12 Tight junction: TJP1 EPB41 hsa04261__3 1.26264478242304e-12 DOWN -7.09896088646206 3.47875300025352e-12 Adrenergic signaling in cardiomyocytes: RYR2 hsa04010__64 1.274042006061e-12 UP 7.09771861489212 3.50501453790427e-12 MAPK signaling pathway: DDIT3 hsa05010__47 1.32064897783379e-12 DOWN -7.09274952861233 3.62262690416014e-12 Alzheimer's disease: C00533 hsa05205__158 1.32064897783379e-12 DOWN -7.09274952861233 3.62262690416014e-12 Proteoglycans in cancer: PDCD4 hsa04610__58 1.33255967549351e-12 UP 7.09150725704238 3.64997030649024e-12 Complement and coagulation cascades: F2RL2 hsa04022__3 1.35669813193876e-12 DOWN -7.08902271390249 3.71067800569567e-12 cGMP-PKG signaling pathway: MYL9 hsa05160__56 1.53810301890008e-12 DOWN -7.07163091192323 4.20072030888555e-12 Hepatitis C: MAPK1 hsa05164__24 1.56588881262048e-12 DOWN -7.06914636878333 4.27039924370665e-12 Influenza A: IRF7 hsa04210__58 1.5941668918698e-12 UP 7.06666182564344 4.34121679684544e-12 Apoptosis: BID* hsa05020__59 1.63752577627152e-12 DOWN -7.0629350109336 4.45283781999158e-12 Prion diseases: CCL5 hsa04810__26 80 1.66707226848889e-12 DOWN -7.06045046779371 4.52663120302112e-12 Regulation of actin cytoskeleton: PFN3 ACTB hsa04350__11 1.69714159115864e-12 DOWN -7.05796592465381 4.60162922047199e-12 TGF-beta signaling pathway: SMAD4* hsa05169__11 1.70434341194682e-12 DOWN -6.45670648479947 4.61449750871481e-12 Epstein-Barr virus infection: HLA-A hsa04670__39 1.95763851403874e-12 DOWN -7.03808957953466 5.292665853063e-12 Leukocyte transendothelial migration: MAPK14 hsa04110__60 10 11 12 13 14 9 2.0835831341684e-12 DOWN -7.02939367854503 5.625075731469e-12 Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 hsa05218__9 2.12100443741427e-12 UP 7.02690913540514 5.71788714189585e-12 Melanoma: CCND1 hsa05213__31 2.53340280100082e-12 UP 7.0020637040062 6.8198622680237e-12 Endometrial cancer: MYC hsa04530__11 43 2.55596834409617e-12 DOWN -7.00082143243625 6.87076469035293e-12 Tight junction: TJP1 ACTN4 hsa05223__9 2.60169238334292e-12 DOWN -6.99833688929636 6.98368569757336e-12 Non-small cell lung cancer: BAD hsa04970__27 2.62485426550968e-12 DOWN -6.99709461772641 7.03580765319926e-12 Salivary secretion: PRKCA hsa05152__82 2.74373130626446e-12 UP 6.99088325987667 7.34397596078479e-12 Tuberculosis: IL6 hsa04915__21 2.84262022489394e-12 DOWN -6.98591417359689 7.58705028774959e-12 Estrogen signaling pathway: CREB3 hsa05200__213 2.84262022489394e-12 DOWN -6.98591417359689 7.58705028774959e-12 Pathways in cancer: CSF2RA hsa04921__33 3.10538852867282e-12 UP 6.97349145789742 8.27663127003721e-12 Oxytocin signaling pathway: C00942 hsa04662__24 3.54477149276669e-12 DOWN -6.95485738434821 9.43431393046544e-12 B cell receptor signaling pathway: FOS hsa04520__43 3.6077798967423e-12 DOWN -6.95237284120832 9.58842775951737e-12 Adherens junction: ACTB hsa04730__20 3.63969458410744e-12 DOWN -6.95113056963837 9.65958492025125e-12 Long-term depression: C00025 hsa04390__74 3.73710861257417e-12 UP 6.94740375492853 9.90412846689261e-12 Hippo signaling pathway: AXIN1 hsa05142__7 3.77013863980805e-12 DOWN -6.94616148335858 9.97759225943566e-12 Chagas disease (American trypanosomiasis): C1QA hsa04270__46 4.00954892278198e-12 UP 6.93746558236895 1.05962622024013e-11 Vascular smooth muscle contraction: ITPR1* hsa04919__88 4.18961399863345e-12 DOWN -6.93125422451922 1.1056579639652e-11 Thyroid hormone signaling pathway: FOXO1 hsa03320__33 4.33935287576074e-12 DOWN -6.92628513823943 1.14196695427933e-11 PPAR signaling pathway: CYP7A1 hsa04510__20 69 4.33935287576074e-12 DOWN -6.92628513823943 1.14196695427933e-11 Focal adhesion: VASP ACTB hsa04910__46 5.12534729288407e-12 DOWN -6.90268197841044 1.34692693193415e-11 Insulin signaling pathway: FBP1 hsa04910__17 5.21578687933442e-12 DOWN -6.90019743527054 1.36877982489796e-11 Insulin signaling pathway: C00031 hsa04740__33 5.30779017150791e-12 DOWN -6.89771289213065 1.39098155261693e-11 Olfactory transduction: CNGA3* hsa05152__129 5.64250184274976e-12 DOWN -6.88901699114102 1.47663801706501e-11 Tuberculosis: IFNB1 hsa05100__55 6.15681012328739e-12 DOWN -6.87659427544155 1.60899112957677e-11 Bacterial invasion of epithelial cells: ACTB* hsa04622__5 33 6.31987010651808e-12 UP 6.87286746073171 1.64931054585381e-11 RIG-I-like receptor signaling pathway: MAVS TMEM173 hsa05162__101 6.77567029745776e-12 DOWN -6.86292928817213 1.76580922176465e-11 Measles: CDKN1B hsa04370__37 6.83486310169971e-12 DOWN -6.86168701660219 1.77876838893265e-11 VEGF signaling pathway: CASP9 hsa04370__14 7.26363973554709e-12 UP 6.85299111561256 1.88774260900318e-11 VEGF signaling pathway: PTGS2 hsa04068__58 7.78599725252306e-12 DOWN -6.84305294305298 2.02070287810647e-11 FoxO signaling pathway: KLF2 hsa04068__55 9.33864618600339e-12 DOWN -6.8169652400841 2.42031947358626e-11 FoxO signaling pathway: ATM hsa04742__27 1.02691213937065e-11 DOWN -6.80330025281468 2.65780703839869e-11 Taste transduction: CALHM1 hsa05205__22 1.0538269738637e-11 UP 6.79957343810484 2.7237151085143e-11 Proteoglycans in cancer: PPP1R12A hsa04910__26 1.06295122535593e-11 UP 6.79833116653489 2.74352383577445e-11 Insulin signaling pathway: RPS6 hsa04520__44 52 45 1.11934429751618e-11 DOWN -6.79087753711521 2.88511376547724e-11 Adherens junction: ACTB ACTN4 CTNNA1 hsa05216__12 1.25328711365766e-11 UP 6.32502569838509 3.22592669392158e-11 Thyroid cancer: CDH1 hsa04115__55 1.26257106211528e-11 UP 6.77348573513595 3.24537760015679e-11 p53 signaling pathway: SHISA5 hsa04151__63 1.38756118371254e-11 DOWN -6.75982074786653 3.56178615327303e-11 PI3K-Akt signaling pathway: CASP9 hsa04520__1 13 1.43595283596968e-11 DOWN -6.75485166158675 3.68097596014602e-11 Adherens junction: SMAD4 SMAD2 hsa05152__76 1.46076464615649e-11 UP 6.75236711844685 3.73947788845782e-11 Tuberculosis: TNF* hsa04611__7 1.64659641316914e-11 DOWN -6.73497531646759 4.20946212291812e-11 Platelet activation: ITPR1 hsa04910__12 1.66072229600331e-11 UP 6.73373304489765 4.23405318071942e-11 Insulin signaling pathway: FASN hsa05132__48 1.66072229600331e-11 DOWN -6.73373304489765 4.23405318071942e-11 Salmonella infection: KLC3 hsa05218__14 1.71842210449496e-11 DOWN -6.72876395861786 4.37522375927646e-11 Melanoma: BAD hsa04933__25 1.90355431981791e-11 UP 6.7138566997785 4.84002512440847e-11 AGE-RAGE signaling pathway in diabetic complications: IL1A hsa05168__106 134 1.91983522382022e-11 UP 6.71261442820855 4.87482484534891e-11 Herpes simplex infection: SRSF8 C1QBP hsa05211__4 2.00330698938992e-11 UP 6.70640307035881 5.07991070588889e-11 Renal cell carcinoma: SLC2A1 hsa05152__77 2.05508482605789e-11 UP 6.70267625564897 5.20418381154012e-11 Tuberculosis: IL12A hsa04151__28 2.10817221920408e-11 DOWN -6.69894944093913 5.33143418557802e-11 PI3K-Akt signaling pathway: BCL2L11 hsa04540__22 2.21836740119626e-11 DOWN -6.69149581151945 5.60257035866636e-11 Gap junction: C00547 hsa04973__5 2.60602713953851e-11 DOWN -6.66789265169046 6.57278522844679e-11 Carbohydrate digestion and absorption: SLC2A5 hsa05215__34 2.93332646272602e-11 DOWN -6.6505008497112 7.38836517890375e-11 Prostate cancer: BAD hsa04068__66 2.95818669040281e-11 DOWN -6.64925857814125 7.44100775269998e-11 FoxO signaling pathway: BNIP3 hsa05110__13 3.03393320608041e-11 UP 6.64553176343141 7.62133755912445e-11 Vibrio cholerae infection: C00238 hsa05213__29 3.32865754057297e-11 UP 6.63186677616199 8.35053073262564e-11 Endometrial cancer: CCND1 hsa04550__62 63 3.53055201400837e-11 UP 6.62317087517237 8.8452096457623e-11 Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4 hsa04360__108 3.68205013041651e-11 DOWN -6.61695951732263 9.21247962057607e-11 Axon guidance: CFL1 hsa04210__84 3.93777486390674e-11 DOWN -6.60702134476306 9.82613408935028e-11 Apoptosis: FAS** hsa05152__6 3.93777486390674e-11 DOWN -6.60702134476306 9.82613408935028e-11 Tuberculosis: IL10 hsa04620__18 4.54024058731647e-11 UP 6.58590272807396 1.13144722328483e-10 Toll-like receptor signaling pathway: CXCL11 hsa04919__102 4.77370089278783e-11 UP 6.57844909865427 1.18805085795342e-10 Thyroid hormone signaling pathway: BMP4 hsa04610__52 4.81373629746229e-11 UP 6.57720682708433 1.19642996070524e-10 Complement and coagulation cascades: CPB2 hsa04611__25 5.103328841477e-11 DOWN -6.5685109260947 1.26673116157665e-10 Platelet activation: ORAI1 hsa04010__61 5.23259476616097e-11 UP 6.56478411138486 1.29539467267674e-10 MAPK signaling pathway: ATF4 hsa04933__62 5.23259476616097e-11 UP 6.56478411138486 1.29539467267674e-10 AGE-RAGE signaling pathway in diabetic complications: AGER** hsa04670__73 5.59316563372515e-11 DOWN -6.55484593882528 1.38283660865389e-10 Leukocyte transendothelial migration: MYL12B* hsa04713__14 5.63991162336514e-11 DOWN -6.55360366725533 1.39256162159042e-10 Circadian entrainment: PRKCA hsa04024__107 64 5.68703970572533e-11 DOWN -6.55236139568539 1.40051737969304e-10 cAMP signaling pathway: NFKBIA NFKB1 hsa04740__13 5.68703970572533e-11 DOWN -6.55236139568539 1.40051737969304e-10 Olfactory transduction: CNGA3 hsa05205__91 6.02789407673983e-11 UP 6.54366549469576 1.48251478667463e-10 Proteoglycans in cancer: RAC1* hsa04722__53 6.18001848113355e-11 DOWN -6.53993867998592 1.51794179425489e-10 Neurotrophin signaling pathway: JUN hsa04152__57 6.23155618271699e-11 UP 6.53869640841597 1.52860235865865e-10 AMPK signaling pathway: ACACA* hsa04725__64 7.17481468941723e-11 DOWN -6.51757779172687 1.75768928310495e-10 Cholinergic synapse: KCNJ3 hsa04728__60 7.23445159751155e-11 DOWN -6.51633552015693 1.76999147808909e-10 Dopaminergic synapse: CACNA1A hsa05161__68 7.35518329044936e-11 DOWN -6.51385097701703 1.79718977929185e-10 Hepatitis B: JUN hsa04620__76 7.85812234132464e-11 DOWN -6.50391280445746 1.91758595835701e-10 Toll-like receptor signaling pathway: CCL3L3 hsa04666__51 8.18937505216754e-11 DOWN -6.49770144660772 1.99324296930347e-10 Fc gamma R-mediated phagocytosis: NCF1 hsa04710__5 8.18937505216754e-11 DOWN -6.49770144660772 1.99324296930347e-10 Circadian rhythm: RORA hsa05169__45 9.11584890335355e-11 DOWN -6.48155191619841 2.21587064545942e-10 Epstein-Barr virus infection: RB1 hsa04915__30 9.42099478801117e-11 DOWN -6.47658282991862 2.28413538150619e-10 Estrogen signaling pathway: CREB3* hsa05321__55 9.42099478801117e-11 DOWN -6.47658282991862 2.28413538150619e-10 Inflammatory bowel disease (IBD): IL4* hsa04972__42 9.6563857824913e-11 DOWN -6.47285601520878 2.33818928934293e-10 Pancreatic secretion: CFTR hsa05152__94 9.81649742111551e-11 DOWN -6.47037147206889 2.37389944070477e-10 Tuberculosis: CAMP hsa04014__70 1.048330224981e-10 UP 6.46043329950931 2.53189266418934e-10 Ras signaling pathway: RIN1* hsa04068__68 1.14729256139189e-10 DOWN -6.44676831223989 2.76379836263507e-10 FoxO signaling pathway: ATG12 hsa05010__37 1.14729256139189e-10 DOWN -6.44676831223989 2.76379836263507e-10 Alzheimer's disease: MAPT hsa04151__97 1.19524033459143e-10 UP 6.44055695439016 2.8756166308544e-10 PI3K-Akt signaling pathway: MCL1 hsa04012__24 1.20506225831797e-10 DOWN -6.43931468282021 2.89553962068986e-10 ErbB signaling pathway: CDKN1A hsa05164__20 1.29708418719999e-10 DOWN -6.42813423869069 3.11267073786562e-10 Influenza A: ATF2 hsa04612__17 28 1.44223788591041e-10 DOWN -6.41198470828138 3.45658799442049e-10 Antigen processing and presentation: CD4 HLA-DMA hsa04961__26 1.51447464014375e-10 DOWN -6.4045310788617 3.62509280105745e-10 Endocrine and other factor-regulated calcium reabsorption: TRPV5* hsa03320__8 1.55190704235491e-10 DOWN -6.40080426415185 3.70996607199094e-10 PPAR signaling pathway: GK hsa04022__39 1.59024302568451e-10 DOWN -6.39707744944201 3.7967809977906e-10 cGMP-PKG signaling pathway: KCNJ8 hsa04152__24 1.6697112877452e-10 DOWN -6.38962382002233 3.97137659452307e-10 AMPK signaling pathway: SIRT1 hsa04728__36 1.6697112877452e-10 UP 6.38962382002233 3.97137659452307e-10 Dopaminergic synapse: TH hsa05166__89 90 1.6697112877452e-10 DOWN -6.38962382002233 3.97137659452307e-10 HTLV-I infection: CHUK IKBKG hsa04270__17 1.69705309865337e-10 DOWN -6.38713927688244 4.03130565407038e-10 Vascular smooth muscle contraction: ITPR1 hsa04370__28 1.75305546605914e-10 UP 6.38217019060265 4.15383508288163e-10 VEGF signaling pathway: SHC2 hsa04921__23 1.75305546605914e-10 UP 6.38217019060265 4.15383508288163e-10 Oxytocin signaling pathway: C00219 hsa04015__63 1.81086214765544e-10 DOWN -6.37720110432286 4.28001254772901e-10 Rap1 signaling pathway: GNAI1 hsa05200__203 1.81086214765544e-10 DOWN -6.37720110432286 4.28001254772901e-10 Pathways in cancer: TGFA* hsa04970__28 1.88571207954914e-10 UP 6.37098974647313 4.44024252399403e-10 Salivary secretion: AQP5 hsa04022__57 1.88574429704483e-10 DOWN -6.37098974647313 4.44024252399403e-10 cGMP-PKG signaling pathway: C00144 hsa04370__39 1.88574429704483e-10 UP 6.37098974647313 4.44024252399403e-10 VEGF signaling pathway: RAC1 hsa04062__38 1.90107967263921e-10 DOWN -6.36974747490318 4.47074931775855e-10 Chemokine signaling pathway: NCF1 hsa04921__53 1.96364882279206e-10 UP 6.36477838862339 4.61212017253286e-10 Oxytocin signaling pathway: RGS2 hsa05160__71 1.99568337252752e-10 DOWN -6.3622938454835 4.68150943443097e-10 Hepatitis C: MAPK8 hsa04973__36 2.0118915381626e-10 DOWN -6.36105157391355 4.71364613492209e-10 Carbohydrate digestion and absorption: SLC2A2 hsa04012__48 2.0780199252317e-10 DOWN -6.35608248763376 4.86251486863058e-10 ErbB signaling pathway: CAMK2A hsa03320__66 2.18121136704378e-10 DOWN -6.34862885821408 5.09763203815332e-10 PPAR signaling pathway: UCP1 hsa04068__72 2.23466755357823e-10 DOWN -6.34490204350424 5.2096033910341e-10 FoxO signaling pathway: SMAD2 hsa04726__64 2.23466755357823e-10 DOWN -6.34490204350424 5.2096033910341e-10 Serotonergic synapse: CASP3 hsa04068__47 2.32661806335488e-10 DOWN -6.33869068565451 5.41053878842056e-10 FoxO signaling pathway: GADD45G hsa04068__54 2.32661806335488e-10 DOWN -6.33869068565451 5.41053878842056e-10 FoxO signaling pathway: GADD45G* hsa04933__63 2.46158366381614e-10 UP 6.32999478466488 5.71732472720708e-10 AGE-RAGE signaling pathway in diabetic complications: SELE hsa04530__4 37 11 2.48147828727801e-10 DOWN -6.32875251309493 5.75641691579677e-10 Tight junction: OCLN TJP3 TJP1 hsa05223__24 2.562639037292e-10 DOWN -6.32378342681514 5.93735974238185e-10 Non-small cell lung cancer: STK4 hsa04510__43 2.5833308969253e-10 DOWN -6.32254115524519 5.97057657481259e-10 Focal adhesion: BAD hsa05161__100 2.5833308969253e-10 UP 6.32254115524519 5.97057657481259e-10 Hepatitis B: MMP9* hsa05142__18 2.91400561692538e-10 DOWN -6.30390708169599 6.72655596339408e-10 Chagas disease (American trypanosomiasis): FOS hsa04933__29 3.05754760394533e-10 UP 6.29645345227631 7.04924165375863e-10 AGE-RAGE signaling pathway in diabetic complications: ICAM1 hsa05200__219 3.41985821576854e-10 UP 6.27906165029705 7.87489410224152e-10 Pathways in cancer: MYC** hsa04950__31 3.50278230566498e-10 DOWN -6.27533483558721 8.05597056590514e-10 Maturity onset diabetes of the young: NKX6-1* hsa04360__19 3.61640754992941e-10 DOWN -6.27036574930742 8.30712687813859e-10 Axon guidance: CDC42 hsa04068__53 3.67456171000086e-10 DOWN -6.26788120616753 8.43040470462958e-10 FoxO signaling pathway: SOD2 hsa03320__28 3.82397040277195e-10 DOWN -6.26166984831779 8.76248827659573e-10 PPAR signaling pathway: ACSL1 hsa04662__35 3.85455592986547e-10 DOWN -6.26042757674785 8.82181558126335e-10 B cell receptor signaling pathway: CD79B hsa05152__90 3.94775241983277e-10 DOWN -6.256700762038 9.02412019083428e-10 Tuberculosis: CR1 hsa04062__44 4.01110166627234e-10 DOWN -6.25421621889811 9.15778861594864e-10 Chemokine signaling pathway: MAPK1 hsa04728__54 4.04314733551315e-10 DOWN -6.25297394732816 9.21974980998691e-10 Dopaminergic synapse: CAMK2A hsa05110__50 4.41252129408798e-10 DOWN -6.23930896005875 1.00498515292016e-09 Vibrio cholerae infection: ACTB hsa04068__51 4.44773836892279e-10 DOWN -6.2380666884888 1.01055627511559e-09 FoxO signaling pathway: BCL6 hsa04068__56 4.44773836892279e-10 DOWN -6.2380666884888 1.01055627511559e-09 FoxO signaling pathway: BCL6* hsa04933__12 4.48318450410651e-10 DOWN -6.23682441691885 1.01737967188601e-09 AGE-RAGE signaling pathway in diabetic complications: EGR1 hsa04010__118 4.81485871687996e-10 UP 6.22564397278933 1.09132925561127e-09 MAPK signaling pathway: JUN hsa04622__45 5.21149528362745e-10 UP 6.21322125708986 1.17980718529349e-09 RIG-I-like receptor signaling pathway: MAPK14 hsa03320__57 5.37892546794601e-10 DOWN -6.20825217081007 1.21478376854213e-09 PPAR signaling pathway: APOC3 hsa05142__84 5.37892546794601e-10 DOWN -6.20825217081007 1.21478376854213e-09 Chagas disease (American trypanosomiasis): NFKB1* hsa04115__2 5.4215963880691e-10 UP 6.20700989924013 1.22295073387537e-09 p53 signaling pathway: IGFBP3 hsa05205__415 5.91333078786811e-10 DOWN -6.19334491197071 1.33227200844175e-09 Proteoglycans in cancer: MAPK1****** hsa05031__10 6.29802244772567e-10 DOWN -6.18340673941113 1.41554834680341e-09 Amphetamine addiction: CACNA1C hsa05031__53 6.29802244772567e-10 DOWN -6.18340673941113 1.41554834680341e-09 Amphetamine addiction: CACNA1C* hsa04064__132 8.89203508122938e-10 DOWN -6.12874679033346 1.99619282170012e-09 NF-kappa B signaling pathway: VCAM1 hsa04668__38 9.31815235398795e-10 UP 6.12129316091378 2.0893565958405e-09 TNF signaling pathway: CEBPB hsa04012__35 1.01516764280003e-09 DOWN -6.10762817364437 2.27353992946515e-09 ErbB signaling pathway: CBLC hsa04071__68 1.24213554370036e-09 DOWN -6.07532911282574 2.77853891263449e-09 Sphingolipid signaling pathway: NFKB1 hsa05031__98 1.26151240567235e-09 DOWN -6.07284456968585 2.81852771731075e-09 Amphetamine addiction: FOS hsa04213__13 1.27131102187754e-09 DOWN -6.0716022981159 2.8370468053538e-09 Longevity regulating pathway - multiple species: RPS6KB1* hsa04115__31 1.2811838167173e-09 DOWN -6.07036002654596 2.85568729728565e-09 p53 signaling pathway: ADGRB1 hsa04022__51 1.29113133639603e-09 DOWN -6.06911775497601 2.87444997759258e-09 cGMP-PKG signaling pathway: GTF2I hsa05162__20 1.3214277652108e-09 DOWN -6.06539094026617 2.93841748027348e-09 Measles: NFKB1 hsa04726__38 1.39483938967225e-09 DOWN -6.05669503927654 3.09799434183706e-09 Serotonergic synapse: PLA2G4B hsa04068__44 1.40564606773134e-09 DOWN -6.05545276770659 3.11831046194472e-09 FoxO signaling pathway: CDKN1B hsa04110__96 97 1.41653433732942e-09 UP 6.05421049613665 3.13506244975499e-09 Cell cycle: TFDP1 E2F4 hsa04520__4 1.41653433732942e-09 DOWN -6.05421049613665 3.13506244975499e-09 Adherens junction: CTNND1 hsa04666__27 1.55378011434435e-09 DOWN -6.03930323729728 3.43476804100357e-09 Fc gamma R-mediated phagocytosis: ARPC5 hsa04012__47 1.57788061339697e-09 DOWN -6.03681869415739 3.48394556119025e-09 ErbB signaling pathway: PRKCA hsa04919__99 1.63973679890416e-09 DOWN -6.03060733630765 3.61627399664427e-09 Thyroid hormone signaling pathway: WNT4 hsa04010__14 1.69091730372972e-09 DOWN -6.02563825002786 3.72477563154531e-09 MAPK signaling pathway: MAPT hsa05031__96 1.70395369683722e-09 DOWN -6.02439597845792 3.7490971854299e-09 Amphetamine addiction: PDYN hsa05030__78 1.75708563910377e-09 DOWN -6.01942689217813 3.86147826418243e-09 Cocaine addiction: GRIA2 hsa04014__62 1.78425356790333e-09 DOWN -6.01694234903824 3.91660333421771e-09 Ras signaling pathway: RASSF5 hsa04213__2 1.79799059164885e-09 DOWN -6.01570007746829 3.94215206733745e-09 Longevity regulating pathway - multiple species: RPS6KB1 hsa04630__36 1.82577448779088e-09 UP 6.01321553432839 3.99840356941616e-09 Jak-STAT signaling pathway: GFAP hsa04014__58 59 1.94115334246055e-09 DOWN -6.00327736176882 4.24613170021348e-09 Ras signaling pathway: STK4 STK4 hsa04066__48 2.00147651752347e-09 DOWN -5.99830827548903 4.37299346096116e-09 HIF-1 signaling pathway: PFKFB3 hsa04068__42 2.21041005841397e-09 DOWN -5.98215874507972 4.82387979066185e-09 FoxO signaling pathway: CDKN2D hsa05321__92 2.47794723143752e-09 UP 5.96352467153052 5.40146502073213e-09 Inflammatory bowel disease (IBD): IL17F hsa04014__55 2.57394397358031e-09 DOWN -5.95731331368078 5.60421868639327e-09 Ras signaling pathway: MLLT4 hsa04210__106 2.67355595052431e-09 DOWN -5.95110195583105 5.81436531369812e-09 Apoptosis: TUBA1B hsa05168__29 2.71444767420546e-09 UP 5.94861741269115 5.89647072812955e-09 Herpes simplex infection: IKBKG hsa04012__29 2.75594506357192e-09 DOWN -5.94613286955126 5.97970066333907e-09 ErbB signaling pathway: STAT5A* hsa04211__39 2.86240985237337e-09 UP 5.93992151170152 6.20353876886916e-09 Longevity regulating pathway - mammal: TP53* hsa05152__9 2.9281999498557e-09 DOWN -5.93619469699168 6.33881072094338e-09 Tuberculosis: TCIRG1 hsa05160__66 2.9504554272622e-09 UP 5.93495242542174 6.37963837494324e-09 Hepatitis C: GSK3B hsa04068__48 2.97287557941255e-09 DOWN -5.93371015385179 6.42072783185769e-09 FoxO signaling pathway: FASLG hsa05014__53 3.20639873254463e-09 UP 5.92128743815232 6.91713343105782e-09 Amyotrophic lateral sclerosis (ALS): RAB5A hsa04340__52 3.61765225817146e-09 DOWN -5.90141109303317 7.79537682695432e-09 Hedgehog signaling pathway: BCL2* hsa04917__37 3.64499420980444e-09 UP 5.90016882146322 7.84529681583338e-09 Prolactin signaling pathway: TNFSF11 hsa04971__55 3.7002829122415e-09 DOWN -5.89768427832333 7.95518488798831e-09 Gastric acid secretion: MYLK4 hsa04062__8 41 3.78474966196759e-09 DOWN -5.89395746361348 8.11820161511086e-09 Chemokine signaling pathway: PXN PTK2B hsa04912__43 3.78474966196759e-09 DOWN -5.89395746361348 8.11820161511086e-09 GnRH signaling pathway: PTK2B hsa04066__52 3.95935067411266e-09 DOWN -5.8865038341938 8.48303297224366e-09 HIF-1 signaling pathway: FLT1 hsa04210__86 4.04956663275044e-09 DOWN -5.88277701948396 8.66644157510032e-09 Apoptosis: BCL2L11 hsa05223__22 4.20439114711222e-09 DOWN -5.87656566163423 8.9875437604367e-09 Non-small cell lung cancer: BAD* hsa04115__25 4.36497074986777e-09 UP 5.87035430378449 9.32020458977447e-09 p53 signaling pathway: CD82 hsa05150__48 4.4308602553596e-09 DOWN -5.8678697606446 9.45015484656152e-09 Staphylococcus aureus infection: C3AR1 hsa04611__92 4.4977172951098e-09 DOWN -5.8653852175047 9.58187165250717e-09 Platelet activation: RHOA* hsa05162__105 4.59984719617732e-09 UP 5.86165840279486 9.78834980930599e-09 Measles: GSK3B hsa04210__114 4.95684226090076e-09 DOWN -5.84923568709539 1.05360934482268e-08 Apoptosis: HRK hsa04921__65 5.18383000092845e-09 UP 5.84178205767571 1.10061204200504e-08 Oxytocin signaling pathway: TRPM2 hsa05161__125 5.26171605188258e-09 DOWN -5.83929751453582 1.11588763673672e-08 Hepatitis B: CDKN1A hsa04670__15 5.46139127356728e-09 DOWN -5.83308615668608 1.15692832052231e-08 Leukocyte transendothelial migration: PECAM1 hsa05133__59 5.50226746867302e-09 DOWN -5.83184388511614 1.16427483937349e-08 Pertussis: C3 hsa04210__64 5.58480355264259e-09 UP 5.82935934197624 1.18041010972052e-08 Apoptosis: TNFRSF10D* hsa04740__10 5.62652202137049e-09 DOWN -5.82811707040629 1.18789155934328e-08 Olfactory transduction: ANO2 hsa05162__93 6.15140791538346e-09 UP 5.81320981156693 1.29724977250343e-08 Measles: TP53 hsa05220__6 7.08128030082358e-09 UP 5.78960665173794 1.4916732830995e-08 Chronic myeloid leukemia: TP53 hsa04210__51 7.2937813925511e-09 DOWN -5.78463756545815 1.53471615191529e-08 Apoptosis: LMNA hsa04068__14 7.45721394315888e-09 DOWN -5.78091075074831 1.56559832393246e-08 FoxO signaling pathway: G6PC hsa04650__14 7.45721394315888e-09 UP 5.78091075074831 1.56559832393246e-08 Natural killer cell mediated cytotoxicity: CSF2 hsa04114__59 8.51522916986198e-09 UP 5.75854986248926 1.78572718863512e-08 Oocyte meiosis: REC8* hsa04917__34 8.64142716642856e-09 UP 5.75606531934937 1.80815608526941e-08 Prolactin signaling pathway: ELF5 hsa05321__75 8.64142716642856e-09 DOWN -5.75606531934937 1.80815608526941e-08 Inflammatory bowel disease (IBD): IL10 hsa04724__52 9.09760073341422e-09 DOWN -5.74736941835974 1.9014896304878e-08 Glutamatergic synapse: CACNA1A hsa04919__84 9.43768392068728e-09 UP 5.74115806051 1.97037867633016e-08 Thyroid hormone signaling pathway: TP53* hsa04921__46 9.71861819387668e-09 DOWN -5.73618897423022 2.02677953233011e-08 Oxytocin signaling pathway: C00942* hsa04350__10 9.7901120350561e-09 DOWN -5.73494670266027 2.03942577759095e-08 TGF-beta signaling pathway: SMAD4 hsa04530__11 20 16 9.93463659253592e-09 DOWN -5.73246215952038 2.06724054898948e-08 Tight junction: TJP1 ACTB CTTN hsa04662__16 1.00812340491339e-08 DOWN -5.72997761638048 2.09542464361977e-08 B cell receptor signaling pathway: VAV3 hsa04340__33 1.03807633003915e-08 DOWN -5.72500853010069 2.15529881120836e-08 Hedgehog signaling pathway: HHIP* hsa04066__53 1.08463369380956e-08 DOWN -5.71755490068101 2.24699747592963e-08 HIF-1 signaling pathway: EGF* hsa04370__25 1.08463369380956e-08 UP 5.71755490068101 2.24699747592963e-08 VEGF signaling pathway: PXN hsa05220__21 1.10059905913622e-08 DOWN -5.71507035754112 2.27756126885127e-08 Chronic myeloid leukemia: NFKBIA hsa04660__26 1.10866715371927e-08 DOWN -5.71382808597117 2.2917333133537e-08 T cell receptor signaling pathway: GRB2 hsa04650__36 1.18391412737457e-08 UP 5.70264764184165 2.44458752234814e-08 Natural killer cell mediated cytotoxicity: CASP3 hsa05213__13 1.20129752940139e-08 DOWN -5.70016309870175 2.47775857052164e-08 Endometrial cancer: CASP9 hsa04152__35 1.30143060682472e-08 DOWN -5.68649811143234 2.68134661208734e-08 AMPK signaling pathway: PFKFB1 hsa04727__13 1.38934729324505e-08 DOWN -5.67531766730281 2.85934672947147e-08 GABAergic synapse: CACNA1A hsa04064__4 1.39946479947912e-08 DOWN -5.67407539573287 2.87387361554237e-08 NF-kappa B signaling pathway: BIRC2 hsa05231__60 1.39946479947912e-08 DOWN -5.67407539573287 2.87387361554237e-08 Choline metabolism in cancer: PRKCA hsa04917__68 1.41991498152432e-08 UP 5.67159085259297 2.91268586275568e-08 Prolactin signaling pathway: CCND1 hsa04010__66 1.45113558177479e-08 UP 5.66786403788313 2.97348283332043e-08 MAPK signaling pathway: TP53 hsa04115__49 1.53768607568365e-08 UP 5.65792586532356 3.1473988411869e-08 p53 signaling pathway: MDM2* hsa04360__117 1.54885123729017e-08 DOWN -5.65668359375361 3.16680247537349e-08 Axon guidance: CFL1* hsa04610__44 1.59430454537413e-08 DOWN -5.65171450747382 3.25619373995434e-08 Complement and coagulation cascades: C3 hsa04210__60 1.82850535327261e-08 UP 5.62811134764483 3.73046857632924e-08 Apoptosis: BBC3 hsa04150__56 2.12624362280599e-08 UP 5.60202364467594 4.33320148292023e-08 mTOR signaling pathway: EIF4B hsa04917__65 2.14153100034845e-08 UP 5.60078137310599 4.35962811446884e-08 Prolactin signaling pathway: CYP17A1 hsa04921__76 2.21962333472885e-08 UP 5.59457001525626 4.5137145518999e-08 Oxytocin signaling pathway: CDKN1A hsa05130__9 2.23556881354932e-08 DOWN -5.59332774368631 4.54122573044235e-08 Pathogenic Escherichia coli infection: TLR4 hsa04010__62 2.28407527228017e-08 DOWN -5.58960092897647 4.63474885163547e-08 MAPK signaling pathway: MEF2C hsa04921__59 2.30046994926722e-08 UP 5.58835865740653 4.66298061992785e-08 Oxytocin signaling pathway: CCND1 hsa05134__10 2.35034226046704e-08 DOWN -5.58463184269668 4.75893653816547e-08 Legionellosis: NFKB1 hsa05215__8 2.36719837371505e-08 DOWN -5.58338957112674 4.78790715200278e-08 Prostate cancer: NFKBIA hsa04151__33 2.43580384011849e-08 UP 5.57842048484695 4.921371414605e-08 PI3K-Akt signaling pathway: TP53 hsa04010__120 2.47082636802653e-08 DOWN -5.57593594170705 4.9867698662963e-08 MAPK signaling pathway: NFATC1 hsa04064__50 2.56053436759476e-08 DOWN -5.56972458385732 5.16227905226454e-08 NF-kappa B signaling pathway: NFKBIA* hsa04933__21 2.57885147226432e-08 DOWN -5.56848231228737 5.19363549451732e-08 AGE-RAGE signaling pathway in diabetic complications: SMAD4 hsa05200__129 130 2.59729571176331e-08 UP 5.56724004071743 5.21959213091257e-08 Pathways in cancer: CTBP1 HDAC1 hsa05220__12 13 2.59729571176331e-08 UP 5.56724004071743 5.21959213091257e-08 Chronic myeloid leukemia: HDAC1 CTBP1 hsa03320__32 2.61586793984403e-08 DOWN -5.56599776914748 5.24569462002874e-08 PPAR signaling pathway: FABP3 hsa04668__47 2.61586793984403e-08 DOWN -5.56599776914748 5.24569462002874e-08 TNF signaling pathway: CASP7 hsa04350__41 2.7106791791938e-08 DOWN -5.55978641129774 5.43002790800122e-08 TGF-beta signaling pathway: SMAD4*** hsa04015__67 2.74953010147088e-08 UP 5.55730186815785 5.4902944321613e-08 Rap1 signaling pathway: AKT3 hsa04913__47 2.74953010147088e-08 DOWN -5.55730186815785 5.4902944321613e-08 Ovarian steroidogenesis: INSR hsa04913__51 2.74953010147088e-08 DOWN -5.55730186815785 5.4902944321613e-08 Ovarian steroidogenesis: INSR* hsa04151__109 3.16897390743484e-08 DOWN -5.53245643675891 6.32112735888542e-08 PI3K-Akt signaling pathway: RXRA hsa04530__5 11 31 3.44976600769513e-08 DOWN -5.51754917791955 6.87392399624512e-08 Tight junction: IGSF5 TJP1 MLLT4 hsa04662__10 3.57375560345568e-08 UP 5.51133782006981 7.09840040052138e-08 B cell receptor signaling pathway: GSK3B hsa05216__5 3.57375560345568e-08 DOWN -5.51133782006981 7.09840040052138e-08 Thyroid cancer: MAPK1 hsa05216__14 3.57375560345568e-08 DOWN -5.51133782006981 7.09840040052138e-08 Thyroid cancer: MAPK1* hsa05166__32 4.00025851195108e-08 DOWN -5.49146147495066 7.93715495665901e-08 HTLV-I infection: STAT5A hsa04071__11 4.08554587302208e-08 DOWN -5.48773466024082 8.09782773777266e-08 Sphingolipid signaling pathway: PRKCA hsa04918__10 4.14338086375772e-08 UP 5.48525011710093 8.20380678925264e-08 Thyroid hormone synthesis: TG hsa05014__5 4.2020093539307e-08 UP 5.48276557396103 8.31113218530083e-08 Amyotrophic lateral sclerosis (ALS): TOMM40 hsa04115__21 4.29146294976964e-08 UP 5.47903875925119 8.47913657478144e-08 p53 signaling pathway: DDB2 hsa04064__93 4.32168904679655e-08 UP 5.47779648768124 8.52988836022135e-08 NF-kappa B signaling pathway: PLAU hsa05166__65 4.47594235182781e-08 UP 5.47158512983151 8.82507416483154e-08 HTLV-I infection: PTTG2 hsa05132__55 4.53912677260079e-08 DOWN -5.46910058669161 8.93091016305433e-08 Salmonella infection: IL18 hsa05152__51 4.53912677260079e-08 DOWN -5.46910058669161 8.93091016305433e-08 Tuberculosis: CASP3 hsa04152__81 4.60317551734724e-08 UP 5.46661604355172 9.04745480867726e-08 AMPK signaling pathway: LIPE hsa04072__36 4.63552757513133e-08 DOWN -5.46537377198177 9.10152174887333e-08 Phospholipase D signaling pathway: MTOR hsa04912__26 4.66810000870994e-08 DOWN -5.46413150041183 9.15590805466178e-08 GnRH signaling pathway: PLD1 hsa05218__8 4.86824437902982e-08 UP 5.45667787099214 9.53851010239524e-08 Melanoma: CDK4 hsa04610__23 4.93678901591683e-08 DOWN -5.45419332785225 9.66273600094554e-08 Complement and coagulation cascades: BDKRB1 hsa04024__118 5.04136308125273e-08 DOWN -5.45046651314241 9.85715008290726e-08 cAMP signaling pathway: MYL9 hsa04390__77 5.36813016965884e-08 UP 5.43928606901289 1.04851523791985e-07 Hippo signaling pathway: CCND1 hsa04950__18 5.40568014314293e-08 UP 5.43804379744294 1.05475316604004e-07 Maturity onset diabetes of the young: SLC2A2 hsa05200__173 5.55844174559766e-08 DOWN -5.43307471116315 1.08231212849513e-07 Pathways in cancer: CCNA1 hsa05221__16 5.55844174559766e-08 DOWN -5.43307471116315 1.08231212849513e-07 Acute myeloid leukemia: CCNA1 hsa04115__36 5.63638315659582e-08 UP 5.43059016802326 1.09635237590513e-07 p53 signaling pathway: EI24 hsa04115__39 5.83589861644528e-08 UP 5.42437881017352 1.13398691833513e-07 p53 signaling pathway: BAX hsa04620__29 5.87661489084538e-08 DOWN -5.42313653860358 1.14071894420439e-07 Toll-like receptor signaling pathway: CXCL8 hsa04972__18 5.95887483691224e-08 DOWN -5.42065199546368 1.15549286053231e-07 Pancreatic secretion: PRKCA hsa05205__318 6.00042211262984e-08 DOWN -5.41940972389374 1.16234980924036e-07 Proteoglycans in cancer: HSPB2 hsa05162__78 6.04225001170704e-08 DOWN -5.41816745232379 1.16924693841375e-07 Measles: FAS hsa04024__113 6.12675501315415e-08 DOWN -5.41568290918389 1.18437990429184e-07 cAMP signaling pathway: PTCH1 hsa05211__21 6.21240462295291e-08 DOWN -5.413198366044 1.19970280437087e-07 Renal cell carcinoma: TGFB1* hsa04020__18 6.34294282853131e-08 DOWN -5.40947155133416 1.22114647282893e-07 Calcium signaling pathway: C00002 hsa04020__17 6.34294282853131e-08 DOWN -5.40947155133416 1.22114647282893e-07 Calcium signaling pathway: C00004 hsa04020__15 6.34294282853131e-08 DOWN -5.40947155133416 1.22114647282893e-07 Calcium signaling pathway: C13051 hsa04912__19 6.38719772658807e-08 DOWN -5.40822927976421 1.22840783298454e-07 GnRH signaling pathway: MAPK7 hsa04650__39 6.61239815921652e-08 DOWN -5.40201792191448 1.27041882834027e-07 Natural killer cell mediated cytotoxicity: FAS hsa04919__87 6.65835230207431e-08 DOWN -5.40077565034453 1.27794116196094e-07 Thyroid hormone signaling pathway: BAD hsa04211__51 6.79807869046926e-08 UP 5.39704883563469 1.30342753667263e-07 Longevity regulating pathway - mammal: NFKB1 hsa04066__59 7.08610276253854e-08 DOWN -5.38959520621501 1.35726677786034e-07 HIF-1 signaling pathway: NOS2 hsa05132__41 7.80487457513023e-08 DOWN -5.37220340423575 1.49341744670771e-07 Salmonella infection: ACTB* hsa05200__5 7.91315338858183e-08 DOWN -5.36971886109585 1.51105845702696e-07 Pathways in cancer: CASP3* hsa05210__7 7.91315338858183e-08 DOWN -5.36971886109585 1.51105845702696e-07 Colorectal cancer: CASP3* hsa04012__65 8.71289123391098e-08 DOWN -5.3523270591166 1.66208351558566e-07 ErbB signaling pathway: MYC hsa04620__66 8.7729172807154e-08 DOWN -5.35108478754665 1.67183687327223e-07 Toll-like receptor signaling pathway: CASP8 hsa04390__89 9.39562485347746e-08 DOWN -5.33866207184718 1.78869089155868e-07 Hippo signaling pathway: ID2 hsa05200__80 1.11453867114668e-07 UP 5.30760528259851 2.11965401121924e-07 Pathways in cancer: TP53 hsa05220__4 1.14531390194245e-07 DOWN -5.30263619631872 2.17598060844273e-07 Chronic myeloid leukemia: PTPN11 hsa04151__5 1.16100830229895e-07 UP 5.30015165317882 2.20357030305023e-07 PI3K-Akt signaling pathway: EIF4B hsa04024__25 1.20116018286633e-07 DOWN -5.29394029532909 2.27518143508652e-07 cAMP signaling pathway: CFTR hsa04720__4 15 1.20116018286633e-07 DOWN -5.29394029532909 2.27518143508652e-07 Long-term potentiation: CREBBP ATF4 hsa04014__37 1.29427936503658e-07 DOWN -5.28027530805967 2.44909458902693e-07 Ras signaling pathway: FASLG hsa04015__18 1.38496544100823e-07 UP 5.2678525923602 2.6180584141393e-07 Rap1 signaling pathway: CDH1 hsa04210__24 1.39436493161456e-07 DOWN -5.26661032079025 2.63317759447613e-07 Apoptosis: CASP10 hsa04010__107 1.40382611325879e-07 DOWN -5.26536804922031 2.64838279800529e-07 MAPK signaling pathway: MAP3K2 hsa04310__13 1.46191073242889e-07 UP 5.25791441980063 2.75519585379528e-07 Wnt signaling pathway: NFATC1 hsa04115__19 1.4817837680604e-07 UP 5.25542987666073 2.78985140299147e-07 p53 signaling pathway: RFWD2 hsa04064__113 1.62839545512473e-07 DOWN -5.23803807468147 3.06281787805743e-07 NF-kappa B signaling pathway: CFLAR hsa04210__75 1.65045261621585e-07 UP 5.23555353154158 3.10120046586959e-07 Apoptosis: BAK1* hsa04064__116 1.76514326812473e-07 DOWN -5.22313081584211 3.31339080999636e-07 NF-kappa B signaling pathway: GADD45B hsa04976__95 96 1.84996528717595e-07 DOWN -5.21443491485248 3.46914648164033e-07 Bile secretion: SLC51A SLC51B hsa04666__42 2.07271410266779e-07 UP 5.19331629816338 3.88298085634374e-07 Fc gamma R-mediated phagocytosis: MYO10 hsa04932__95 2.18629816154165e-07 UP 5.18337812560381 4.09168749555455e-07 Non-alcoholic fatty liver disease (NAFLD): IL1A hsa04310__32 2.27540966018227e-07 DOWN -5.17592449618413 4.25422363331591e-07 Wnt signaling pathway: PPARD hsa04912__33 2.33675624587486e-07 DOWN -5.17095540990434 4.36457752087362e-07 GnRH signaling pathway: ELK1 hsa04115__1 2.35234080463767e-07 UP 5.16971313833439 4.38932311014317e-07 p53 signaling pathway: SIAH1 hsa05132__6 2.38381173533504e-07 DOWN -5.1672285951945 4.44363318521284e-07 Salmonella infection: NFKB1 hsa04530__20 31 2.61577988717154e-07 DOWN -5.14983679321524 4.87120952229467e-07 Tight junction: ACTB MLLT4 hsa04024__44 67 2.6682506105004e-07 DOWN -5.1461099785054 4.96400286844579e-07 cAMP signaling pathway: CREB3 CREBBP hsa04115__58 2.79466576306059e-07 DOWN -5.13741407751577 5.1940425012768e-07 p53 signaling pathway: CASP3 hsa04933__43 2.96572018053593e-07 DOWN -5.12623363338625 5.5065100980504e-07 AGE-RAGE signaling pathway in diabetic complications: CASP3 hsa04933__26 2.98533880432765e-07 UP 5.1249913618163 5.53746457387132e-07 AGE-RAGE signaling pathway in diabetic complications: IL6 hsa04390__12 3.14686335975561e-07 UP 5.11505318925672 5.8313178037286e-07 Hippo signaling pathway: CTGF hsa05166__120 3.20958419350767e-07 UP 5.11132637454688 5.94168344788267e-07 HTLV-I infection: E2F1 hsa05164__19 3.38279680144457e-07 DOWN -5.10138820198731 6.25617636802594e-07 Influenza A: NFKB1 hsa05164__23 3.40507265442457e-07 DOWN -5.10014593041736 6.28500149082885e-07 Influenza A: IRF3 hsa05222__36 3.40507265442457e-07 UP 5.10014593041736 6.28500149082885e-07 Small cell lung cancer: PTGS2 hsa05200__195 3.45004992120974e-07 DOWN -5.09766138727746 6.36177016874692e-07 Pathways in cancer: BIRC8 hsa04728__24 3.54172808095748e-07 UP 5.09269230099768 6.52441869031285e-07 Dopaminergic synapse: SLC6A3 hsa04530__13 45 20 3.68367598170204e-07 DOWN -5.085238671578 6.77926265388651e-07 Tight junction: EPB41 TJP2 ACTB hsa04742__31 3.70786110763499e-07 DOWN -5.08399640000805 6.81709493272618e-07 Taste transduction: C00076* hsa04710__7 3.78133948598699e-07 DOWN -5.08026958529821 6.94539285842575e-07 Circadian rhythm: PER1 hsa04510__24 69 3.83110363452717e-07 UP 5.07778504215831 7.02992551687163e-07 Focal adhesion: ZYX ACTB hsa04950__16 3.98421732021621e-07 DOWN -5.07033141273863 7.30375058018172e-07 Maturity onset diabetes of the young: PAX4 hsa05212__12 4.19757867656638e-07 DOWN -5.06039324017906 7.68737849246416e-07 Pancreatic cancer: CASP9 hsa04310__57 4.25261742110687e-07 UP 5.05790869703916 7.78059214630945e-07 Wnt signaling pathway: SIAH1 hsa04720__32 4.36479114289582e-07 UP 5.05293961075937 7.97805696254985e-07 Long-term potentiation: ITPR1 hsa05210__16 4.45078915573654e-07 DOWN -5.04921279604953 8.12733996465399e-07 Colorectal cancer: MAPK8 hsa05169__118 4.62771511336192e-07 UP 5.04175916662985 8.44221038641461e-07 Epstein-Barr virus infection: MDM2 hsa04012__31 4.81141546884229e-07 DOWN -5.03430553721017 8.76881635883091e-07 ErbB signaling pathway: BAD hsa04913__36 5.13331661326419e-07 DOWN -5.0218828215107 9.33736874765093e-07 Ovarian steroidogenesis: CYP19A1 hsa04913__37 5.13331661326419e-07 DOWN -5.0218828215107 9.33736874765093e-07 Ovarian steroidogenesis: CYP19A1* hsa04725__18 5.72877888822594e-07 DOWN -5.0007642048216 1.04104212098419e-06 Cholinergic synapse: ITPR1 hsa04360__82 6.14898785938076e-07 UP 4.98709921755218 1.11632349640352e-06 Axon guidance: ILK hsa04213__71 6.7701387190571e-07 DOWN -4.96846514400298 1.22790450319578e-06 Longevity regulating pathway - multiple species: SIRT1** hsa04932__56 7.12570829830483e-07 DOWN -4.9585269714434 1.29114810921068e-06 Non-alcoholic fatty liver disease (NAFLD): CASP7 hsa04916__15 8.14677509329214e-07 DOWN -4.93243926847452 1.47473895956608e-06 Melanogenesis: MITF* hsa05162__62 8.79205549053585e-07 UP 4.91753200963515 1.59001658004975e-06 Measles: IL12A hsa04931__67 8.96082274030536e-07 UP 4.91380519492531 1.61897941625325e-06 Insulin resistance: IKBKB** hsa05010__61 9.546596986693e-07 UP 4.90138247922584 1.72315617079694e-06 Alzheimer's disease: GAPDH hsa04610__57 1.05610818598307e-06 UP 4.88150613410669 1.90444076915758e-06 Complement and coagulation cascades: PLAUR hsa04360__51 1.11064729785343e-06 UP 4.87156796154711 2.00086890955569e-06 Axon guidance: FYN hsa05131__12 1.11765231143055e-06 DOWN -4.87032568997717 2.00963511308901e-06 Shigellosis: ARPC5 hsa05161__10 1.11765231143055e-06 DOWN -4.87032568997717 2.00963511308901e-06 Hepatitis B: CASP3 hsa05032__30 1.16057377010231e-06 UP 4.86287206055748 2.08481655260252e-06 Morphine addiction: ADORA1 hsa04012__25 1.20509950231834e-06 UP 4.8554184311378 2.16273349078908e-06 ErbB signaling pathway: CDKN1B hsa04722__70 1.24344661338042e-06 UP 4.84920707328807 2.22942384212005e-06 Neurotrophin signaling pathway: ZNF274 hsa04062__25 1.29910990643458e-06 DOWN -4.84051117229844 2.32478810875292e-06 Chemokine signaling pathway: ROCK1 hsa04666__38 1.29910990643458e-06 DOWN -4.84051117229844 2.32478810875292e-06 Fc gamma R-mediated phagocytosis: CFL1 hsa04670__2 1.323692417152e-06 DOWN -4.8367843575886 2.36652526339544e-06 Leukocyte transendothelial migration: MMP2 hsa05169__79 1.34032865732463e-06 UP 4.8342998144487 2.39399006379562e-06 Epstein-Barr virus infection: ATF2 hsa05169__103 1.44444924888498e-06 DOWN -4.81939255560934 2.57751200252126e-06 Epstein-Barr virus infection: NFKB1* hsa05200__214 1.46254215919363e-06 DOWN -4.81690801246945 2.60732136349604e-06 Pathways in cancer: CSF3R hsa05134__9 1.62538343951888e-06 DOWN -4.79578939578035 2.89487723493458e-06 Legionellosis: CASP7 hsa05120__18 1.63548632597737e-06 DOWN -4.7945471242104 2.91011250616617e-06 Epithelial cell signaling in Helicobacter pylori infection: CCL5 hsa04713__56 1.77244267188433e-06 DOWN -4.77839759380109 3.1508228765096e-06 Circadian entrainment: KCNJ3 hsa04726__72 1.78342245559119e-06 UP 4.77715532223114 3.167344795894e-06 Serotonergic synapse: KCNJ3 hsa04210__99 1.85068648428887e-06 UP 4.76970169281146 3.28370151461642e-06 Apoptosis: BID** hsa05152__15 1.86213156026864e-06 DOWN -4.76845942124151 3.30089169975922e-06 Tuberculosis: CTSD hsa04024__60 1.92038453820189e-06 DOWN -4.76224806339178 3.40094490789949e-06 cAMP signaling pathway: PDE3A hsa05205__77 1.94413631342846e-06 DOWN -4.75976352025188 3.4397666035142e-06 Proteoglycans in cancer: MIR21 hsa04520__44 49 2.05476689593873e-06 DOWN -4.74858307612236 3.63208560439217e-06 Adherens junction: ACTB VCL hsa04932__7 2.13182707113335e-06 DOWN -4.74112944670268 3.76475852129658e-06 Non-alcoholic fatty liver disease (NAFLD): SREBF1 hsa05221__26 2.28037078386736e-06 DOWN -4.72746445943326 4.02330206843828e-06 Acute myeloid leukemia: BAD hsa04211__38 2.36553274214007e-06 UP 4.72001083001358 4.16573197983242e-06 Longevity regulating pathway - mammal: BAX hsa05222__32 2.36553274214007e-06 UP 4.72001083001358 4.16573197983242e-06 Small cell lung cancer: BIRC8 hsa04810__82 83 2.38002006285872e-06 UP 4.71876855844363 4.187319942052e-06 Regulation of actin cytoskeleton: ACTB ARPC5 hsa05200__65 2.39459254628113e-06 DOWN -4.71752628687369 4.20901720716768e-06 Pathways in cancer: STK4 hsa04115__34 2.5296569345248e-06 UP 4.70634584274416 4.4422667102543e-06 p53 signaling pathway: ZMAT3 hsa04210__4 2.65582785233601e-06 DOWN -4.69640767018459 4.65947762328606e-06 Apoptosis: DFFA hsa04064__115 2.92652673178952e-06 DOWN -4.67653132506544 5.12961168753032e-06 NF-kappa B signaling pathway: XIAP hsa04924__23 3.03470924770934e-06 DOWN -4.66907769564575 5.3142764924938e-06 Renin secretion: ITPR1 hsa04921__80 3.05310865375374e-06 DOWN -4.66783542407581 5.34151877132522e-06 Oxytocin signaling pathway: KCNJ2 hsa04668__116 3.14672242816694e-06 UP 4.66162406622607 5.49506639639934e-06 TNF signaling pathway: PGAM5 hsa05031__97 3.14672242816694e-06 DOWN -4.66162406622607 5.49506639639934e-06 Amphetamine addiction: ARC hsa04740__42 3.28241859772863e-06 DOWN -4.65292816523644 5.7267080270493e-06 Olfactory transduction: PDE2A hsa05205__121 3.5070586561532e-06 DOWN -4.63926317796703 6.11295288952863e-06 Proteoglycans in cancer: PLAUR hsa04925__5 3.52819603907022e-06 DOWN -4.63802090639708 6.13840773834532e-06 Aldosterone synthesis and secretion: KCNK3 hsa05032__38 3.52819603907022e-06 DOWN -4.63802090639708 6.13840773834532e-06 Morphine addiction: CACNA1A hsa04390__96 3.57083784338552e-06 UP 4.63553636325719 6.20684949835466e-06 Hippo signaling pathway: FGF1 hsa05205__146 3.61397353365582e-06 UP 4.63305182011729 6.27602243044296e-06 Proteoglycans in cancer: PTK2 hsa04390__52 3.72400942226688e-06 UP 4.62684046226756 6.46113915460708e-06 Hippo signaling pathway: ITGB2 hsa05152__24 25 3.9537934624138e-06 DOWN -4.61441774656809 6.8471685860604e-06 Tuberculosis: ITGB2 ITGAM hsa05205__369 3.9537934624138e-06 DOWN -4.61441774656809 6.8471685860604e-06 Proteoglycans in cancer: HOXD10 hsa05161__227 3.97750515163997e-06 DOWN -4.61317547499814 6.87555858319366e-06 Hepatitis B: MYD88* hsa05164__65 66 3.97750515163997e-06 DOWN -4.61317547499814 6.87555858319366e-06 Influenza A: DNAJC3 HSPA1A hsa05161__214 4.02533805322149e-06 UP 4.61069093185825 6.95184761213527e-06 Hepatitis B: CDKN1B hsa05205__113 4.14734427665443e-06 UP 4.60447957400851 7.15597786577932e-06 Proteoglycans in cancer: TP53 hsa04015__14 4.27288976822053e-06 UP 4.59826821615878 7.3658347472352e-06 Rap1 signaling pathway: MAPK14 hsa04710__23 4.34995644418422e-06 UP 4.59454140144893 7.49181316097355e-06 Circadian rhythm: BHLHE41 hsa04919__104 4.37593999467497e-06 DOWN -4.59329912987899 7.52966231684457e-06 Thyroid hormone signaling pathway: MYC hsa04024__110 4.42835391278443e-06 DOWN -4.59081458673909 7.6128792334144e-06 cAMP signaling pathway: FOS hsa04261__14 16 4.45478590472313e-06 UP 4.58957231516915 7.65131875226213e-06 Adrenergic signaling in cardiomyocytes: TNNI3 TPM1 hsa05200__225 4.48136900843625e-06 DOWN -4.5883300435992 7.68293099165302e-06 Pathways in cancer: PPARD hsa05221__11 4.48136900843625e-06 DOWN -4.5883300435992 7.68293099165302e-06 Acute myeloid leukemia: PPARD hsa05164__35 4.61658014482519e-06 DOWN -4.58211868574946 7.90752424077168e-06 Influenza A: IL18 hsa04725__54 4.72755411444603e-06 UP 4.57714959946968 8.08287004644594e-06 Cholinergic synapse: CHRM1* hsa05223__8 4.72755411444603e-06 DOWN -4.57714959946968 8.08287004644594e-06 Non-small cell lung cancer: CASP9 hsa04115__15 4.92793427427164e-06 UP 4.56845369848005 8.41780772850583e-06 p53 signaling pathway: TSC2 hsa04630__30 5.10613944938433e-06 UP 4.56100006906037 8.71429248446244e-06 Jak-STAT signaling pathway: CDKN1A hsa05166__64 5.19754010540428e-06 UP 4.55727325435052 8.86223036121111e-06 HTLV-I infection: CCNB2 hsa05231__21 5.57905366042397e-06 DOWN -4.54236599551116 9.50411770438498e-06 Choline metabolism in cancer: PCYT1A hsa05215__35 5.77972365824517e-06 DOWN -4.53491236609148 9.83704778427778e-06 Prostate cancer: CASP9 hsa04310__33 5.8826314574041e-06 UP 4.53118555138164 1.00031353017758e-05 Wnt signaling pathway: CCND1 hsa05032__37 6.0937323278827e-06 DOWN -4.52373192196196 1.03527333129219e-05 Morphine addiction: KCNJ3 hsa05120__52 6.16569629745146e-06 UP 4.52124737882206 1.0465531475078e-05 Epithelial cell signaling in Helicobacter pylori infection: LYN hsa04915__66 6.49971975673391e-06 DOWN -4.51006693469254 1.10225391903457e-05 Estrogen signaling pathway: AKT3* hsa04014__66 6.73194625637084e-06 DOWN -4.50261330527286 1.14060658392433e-05 Ras signaling pathway: RAF1* hsa05205__220 7.0539532176589e-06 DOWN -4.49267513271328 1.19408811675505e-05 Proteoglycans in cancer: FAS hsa03320__47 7.26263301709869e-06 DOWN -4.48646377486355 1.22830670019158e-05 PPAR signaling pathway: PLTP hsa04210__63 7.65322124268493e-06 DOWN -4.47528333073402 1.29320168300404e-05 Apoptosis: FAS* hsa04024__123 8.0638469300191e-06 DOWN -4.4641028866045 1.36136283751176e-05 cAMP signaling pathway: PAK1 hsa04064__51 8.39769744829069e-06 DOWN -4.45540698561487 1.41645184069463e-05 NF-kappa B signaling pathway: TNFAIP3 hsa04620__21 8.54478453911078e-06 UP 4.45168017090503 1.43996862322773e-05 Toll-like receptor signaling pathway: IFNA1 hsa04390__94 8.74473447354848e-06 UP 4.44671108462524 1.47234373439047e-05 Hippo signaling pathway: GLI2 hsa04550__9 8.84637856257257e-06 DOWN -4.44422654148535 1.48812402140321e-05 Signaling pathways regulating pluripotency of stem cells: HNF1A hsa04211__62 8.89762301741364e-06 DOWN -4.4429842699154 1.49273514729645e-05 Longevity regulating pathway - mammal: EHMT2 hsa04919__27 8.89762301741364e-06 DOWN -4.4429842699154 1.49273514729645e-05 Thyroid hormone signaling pathway: GATA4 hsa05205__319 8.89762301741364e-06 UP 4.4429842699154 1.49273514729645e-05 Proteoglycans in cancer: KDR hsa04919__103 9.26435837455069e-06 DOWN -4.43428836892577 1.5528750567155e-05 Thyroid hormone signaling pathway: CCND1 hsa04662__6 9.86998754867219e-06 DOWN -4.42062338165636 1.65144315262289e-05 B cell receptor signaling pathway: NFKB1 hsa05200__49 9.86998754867219e-06 DOWN -4.42062338165636 1.65144315262289e-05 Pathways in cancer: CASP9 hsa04932__96 9.92688197118781e-06 UP 4.41938111008641 1.65948498432935e-05 Non-alcoholic fatty liver disease (NAFLD): IL6* hsa05205__233 234 1.01576077443666e-05 DOWN -4.41441202380662 1.69654621792576e-05 Proteoglycans in cancer: ITGA2 C00925 hsa05219__10 1.06345156476793e-05 DOWN -4.40447385124705 1.77462299307188e-05 Bladder cancer: EGFR hsa04976__36 1.09433611062442e-05 DOWN -4.39826249339731 1.82454086234542e-05 Bile secretion: SLC10A1 hsa05200__201 1.10692815429924e-05 UP 4.39577795025742 1.84389893787968e-05 Pathways in cancer: PDGFB hsa04726__16 1.15869336549374e-05 DOWN -4.38583977769784 1.9267122422679e-05 Serotonergic synapse: ITPR1 hsa04726__46 1.15869336549374e-05 DOWN -4.38583977769784 1.9267122422679e-05 Serotonergic synapse: ITPR1* hsa04064__131 1.16532419064589e-05 DOWN -4.38459750612789 1.93602489321276e-05 NF-kappa B signaling pathway: CCL4L1 hsa05161__45 1.2266537729552e-05 UP 4.37341706199837 2.03611522913677e-05 Hepatitis B: PCNA hsa04062__22 41 1.27647165485097e-05 DOWN -4.36472116100874 2.11693754586493e-05 Chemokine signaling pathway: CRK PTK2B hsa04810__32 1.30579968809946e-05 DOWN -4.35975207472895 2.16366632622476e-05 Regulation of actin cytoskeleton: PXN hsa04390__60 1.38195857574713e-05 UP 4.34732935902948 2.28784155403424e-05 Hippo signaling pathway: CTGF* hsa04270__65 1.48729088420287e-05 DOWN -4.33117982862017 2.46005243962781e-05 Vascular smooth muscle contraction: NPR2 hsa04919__49 1.50418365114758e-05 DOWN -4.32869528548028 2.48580569965373e-05 Thyroid hormone signaling pathway: ACTB hsa04921__56 1.53848421839601e-05 DOWN -4.32372619920049 2.54025645550624e-05 Oxytocin signaling pathway: JUN hsa05010__50 1.65516867134922e-05 UP 4.30757666879118 2.7305196957552e-05 Alzheimer's disease: ERN1 hsa05150__66 1.82052508501121e-05 DOWN -4.28645805210208 3.00067248661057e-05 Staphylococcus aureus infection: IL10 hsa05214__27 1.86165904918117e-05 DOWN -4.28148896582229 3.06309750736551e-05 Glioma: MTOR hsa05214__48 1.86165904918117e-05 DOWN -4.28148896582229 3.06309750736551e-05 Glioma: MTOR* hsa04919__42 1.90367738612481e-05 DOWN -4.27651987954251 3.12949239591296e-05 Thyroid hormone signaling pathway: SLC2A1 hsa04933__65 1.91432225016059e-05 UP 4.27527760797256 3.14424082871656e-05 AGE-RAGE signaling pathway in diabetic complications: COL1A1 hsa04722__46 2.0015456802519e-05 DOWN -4.26533943541298 3.28463260540902e-05 Neurotrophin signaling pathway: ATF4* hsa04012__56 2.04656399729386e-05 DOWN -4.2603703491332 3.35557918928025e-05 ErbB signaling pathway: JUN hsa04024__93 2.05796830141789e-05 DOWN -4.25912807756325 3.37133604042216e-05 cAMP signaling pathway: ORAI1 hsa04550__66 2.10419346733065e-05 UP 4.25415899128346 3.44405881978596e-05 Signaling pathways regulating pluripotency of stem cells: MYC hsa05166__83 2.11590327219694e-05 DOWN -4.25291671971351 3.46021083416714e-05 HTLV-I infection: NFKB2 hsa04971__37 2.12767509783699e-05 UP 4.25167444814357 3.47643609463975e-05 Gastric acid secretion: KCNQ1 hsa05168__10 2.19962596258186e-05 UP 4.24422081872388 3.59087505099159e-05 Herpes simplex infection: FOS hsa03320__64 2.22411998431381e-05 DOWN -4.24173627558399 3.62770959247019e-05 PPAR signaling pathway: APOA5 hsa04912__17 2.26134832106499e-05 DOWN -4.23800946087415 3.6852328666792e-05 GnRH signaling pathway: MAPK14 hsa04022__9 2.40299009416886e-05 UP 4.22434447360473 3.91266757967356e-05 cGMP-PKG signaling pathway: ITPR1 hsa04919__30 2.52511743464205e-05 DOWN -4.21316402947521 4.10796161012329e-05 Thyroid hormone signaling pathway: MYH6 hsa05150__35 2.53903091798697e-05 UP 4.21192175790526 4.12702343849267e-05 Staphylococcus aureus infection: FCAR hsa04620__19 3.02537399127937e-05 UP 4.17216906766696 4.9132910368314e-05 Toll-like receptor signaling pathway: CXCL10 hsa05014__2 3.0585392357274e-05 DOWN -4.16968452452706 4.96286288767857e-05 Amyotrophic lateral sclerosis (ALS): SLC1A2 hsa04621__34 35 3.24721216700476e-05 DOWN -4.15601953725765 5.26446217584291e-05 NOD-like receptor signaling pathway: CASP1 PYCARD hsa04722__73 77 3.37297867709471e-05 DOWN -4.14732363626802 5.45893792787335e-05 Neurotrophin signaling pathway: NGFRAP1 YWHAE hsa05210__53 3.37297867709471e-05 UP 4.14732363626802 5.45893792787335e-05 Colorectal cancer: CCND1* hsa04726__45 3.40973179754243e-05 DOWN -4.14483909312812 5.51367129740294e-05 Serotonergic synapse: TRPC1 hsa05152__120 3.44690843982154e-05 DOWN -4.14235454998823 5.56899480518028e-05 Tuberculosis: TGFB1 hsa04971__39 3.50336296888125e-05 DOWN -4.13862773527839 5.65048842792092e-05 Gastric acid secretion: EZR hsa05205__142 3.50336296888125e-05 DOWN -4.13862773527839 5.65048842792092e-05 Proteoglycans in cancer: CTNNB1 hsa05211__48 3.63852437287203e-05 DOWN -4.12993183428876 5.8634539422183e-05 Renal cell carcinoma: JUN hsa04064__133 3.67804222668107e-05 UP 4.12744729114887 5.92205770688409e-05 NF-kappa B signaling pathway: CXCL2 hsa04024__62 3.69795363452475e-05 DOWN -4.12620501957892 5.94901958841782e-05 cAMP signaling pathway: BAD hsa04650__119 3.7179673521732e-05 UP 4.12496274800897 5.97609979019115e-05 Natural killer cell mediated cytotoxicity: KLRC4-KLRK1 hsa04962__10 3.88182007326798e-05 DOWN -4.1150245754494 6.23413668176969e-05 Vasopressin-regulated water reabsorption: AQP2 hsa05161__126 4.1183382236076e-05 UP 4.10135958817998 6.60833264061373e-05 Hepatitis B: MYC* hsa04360__81 4.18517870077452e-05 UP 4.09763277347014 6.70985561327245e-05 Axon guidance: FYN* hsa04213__55 4.70774192390728e-05 DOWN -4.07030279893131 7.54121660274661e-05 Longevity regulating pathway - multiple species: CRYAB hsa04015__82 4.75819922049892e-05 DOWN -4.06781825579141 7.61555054115628e-05 Rap1 signaling pathway: ITGA2B hsa04024__112 4.83484755710991e-05 DOWN -4.06409144108157 7.73164132749746e-05 cAMP signaling pathway: GLI1 hsa04010__134 5.31989280185621e-05 UP 4.04173055282252 8.50006681521073e-05 MAPK signaling pathway: ATF4* hsa04919__25 5.34814874853304e-05 UP 4.04048828125258 8.53795369455699e-05 Thyroid hormone signaling pathway: MTOR hsa04971__56 5.78942865946284e-05 DOWN -4.02185420770337 9.23458102812452e-05 Gastric acid secretion: CAMK2A hsa05152__68 5.82004140772122e-05 DOWN -4.02061193613343 9.27553673037165e-05 Tuberculosis: CD74 hsa04024__76 5.88172740371408e-05 DOWN -4.01812739299353 9.36590321320234e-05 cAMP signaling pathway: C00416 hsa04670__35 6.03866243978453e-05 UP 4.0119160351438 9.60766022384007e-05 Leukocyte transendothelial migration: PTK2 hsa04666__40 6.07052159148883e-05 DOWN -4.01067376357385 9.64202034692098e-05 Fc gamma R-mediated phagocytosis: PLA2G6 hsa05161__26 6.07052159148883e-05 DOWN -4.01067376357385 9.64202034692098e-05 Hepatitis B: MMP9 hsa04115__22 6.2650438849854e-05 UP 4.00322013415417 9.94258231409422e-05 p53 signaling pathway: STEAP3 hsa04210__56 6.33118555395855e-05 UP 4.00073559101427 0.000100390697518043 Apoptosis: BAX hsa05100__24 6.49944348995229e-05 DOWN -3.99452423316454 0.00010297179019916 Bacterial invasion of epithelial cells: ACTB hsa04620__20 6.53359908042137e-05 UP 3.99328196159459 0.000103425717540958 Toll-like receptor signaling pathway: IFNB1* hsa04340__13 6.99336785874952e-05 DOWN -3.97713243118528 0.000110610590964565 Hedgehog signaling pathway: GLI1* hsa04012__40 7.21574197053503e-05 DOWN -3.9696788017656 0.000114031784378766 ErbB signaling pathway: ELK1* hsa05020__24 7.44476565656796e-05 DOWN -3.96222517234592 0.000117256619184335 Prion diseases: PRNP* hsa05020__26 7.44476565656796e-05 DOWN -3.96222517234592 0.000117256619184335 Prion diseases: PRNP** hsa05020__25 8 7.44476565656796e-05 DOWN -3.96222517234592 0.000117256619184335 Prion diseases: PRNP PRNP* hsa05020__10 34 7.44476565656796e-05 DOWN -3.96222517234592 0.000117256619184335 Prion diseases: PRNP PRNP*** hsa04650__16 7.68070837824444e-05 DOWN -3.95477154292624 0.000120871449269023 Natural killer cell mediated cytotoxicity: PRKCA hsa04740__16 7.72070839281225e-05 DOWN -3.95352927135629 0.000121399255816688 Olfactory transduction: PRKG1 hsa04921__60 7.88268660530375e-05 DOWN -3.9485601850765 0.000123842542904396 Oxytocin signaling pathway: ELK1 hsa04022__63 7.92368026075933e-05 DOWN -3.94731791350655 0.000124382583207742 cGMP-PKG signaling pathway: C00575 hsa04922__17 8.13168932463831e-05 UP 3.94110655565682 0.00012754127079295 Glucagon signaling pathway: PKM hsa05152__97 8.60761939687913e-05 UP 3.9274415683874 0.000134893384876863 Tuberculosis: IL18 hsa04724__33 70 69 8.65216690398057e-05 UP 3.92619929681746 0.000135478513438162 Glutamatergic synapse: ITPR1 HOMER3 HOMER3 hsa05231__50 9.06301453080237e-05 DOWN -3.91501885268793 0.000141793541243777 Choline metabolism in cancer: WASF2 hsa04390__88 9.15678348471781e-05 DOWN -3.91253430954804 0.000143141399066429 Hippo signaling pathway: ID1 hsa04622__21 22 23 9.44361871195264e-05 UP 3.90508068012836 0.000147502573231579 RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG hsa04621__23 9.49224184872367e-05 DOWN -3.90383840855841 0.000148138890645779 NOD-like receptor signaling pathway: CASP1 hsa04066__55 9.59019821247848e-05 DOWN -3.90135386541852 0.000149419423227588 HIF-1 signaling pathway: ANGPT1 hsa05161__195 9.59019821247848e-05 UP 3.90135386541852 0.000149419423227588 Hepatitis B: IL6 hsa04668__36 9.9916503945518e-05 UP 3.89141569285894 0.000155545245164564 TNF signaling pathway: CREB3 hsa04151__34 0.000101462445677558 DOWN -3.8876888781491 0.000157690600023269 PI3K-Akt signaling pathway: GYS1 hsa05212__27 0.000101462445677558 DOWN -3.8876888781491 0.000157690600023269 Pancreatic cancer: BCL2L1* hsa05160__37 0.000104085721919744 DOWN -3.88147752029936 0.00016163394337785 Hepatitis C: STAT3 hsa05142__21 0.00011009601818786 DOWN -3.86781253302995 0.000170826109145326 Chagas disease (American trypanosomiasis): TICAM1 hsa04950__30 0.000113508766616685 DOWN -3.86035890361027 0.00017597604989501 Maturity onset diabetes of the young: PAX6* hsa04723__67 0.000118214507947204 DOWN -3.85042073105069 0.000183120412557953 Retrograde endocannabinoid signaling: PRKACA hsa04330__11 0.000120635790903415 DOWN -3.8454516447709 0.000186717175541612 Notch signaling pathway: PTCRA hsa05200__185 0.000121248376605084 DOWN -3.84420937320095 0.000187510863902018 Pathways in cancer: HHIP hsa04213__61 0.000122482356954824 DOWN -3.84172483006106 0.000189263444669502 Longevity regulating pathway - multiple species: ATG5 hsa04750__53 0.000125619307432521 UP 3.83551347221133 0.000193792018608954 Inflammatory mediator regulation of TRP channels: TRPM8 hsa05133__30 0.000125619307432521 UP 3.83551347221133 0.000193792018608954 Pertussis: NOS2 hsa04913__64 0.000129483613198002 UP 3.82805984279164 0.000199589589170669 Ovarian steroidogenesis: PLA2G4B hsa04151__100 0.000132121760121291 DOWN -3.82309075651186 0.000203322512094926 PI3K-Akt signaling pathway: PRKCA hsa04912__46 0.000132121760121291 DOWN -3.82309075651186 0.000203322512094926 GnRH signaling pathway: JUN hsa04933__27 0.000136860787531417 UP 3.81439485552223 0.000210443060369503 AGE-RAGE signaling pathway in diabetic complications: TNF hsa04068__60 0.000137550721142184 DOWN -3.81315258395228 0.000210985963286664 FoxO signaling pathway: RAG1 hsa05205__129 0.000137550721142184 UP 3.81315258395228 0.000210985963286664 Proteoglycans in cancer: AKT3* hsa05211__46 0.000137550721142184 UP 3.81315258395228 0.000210985963286664 Renal cell carcinoma: AKT3 hsa04010__79 0.000141759615157949 UP 3.8056989545326 0.000217087462821342 MAPK signaling pathway: HSPB1 hsa04071__89 0.000141759615157949 UP 3.8056989545326 0.000217087462821342 Sphingolipid signaling pathway: C00533 hsa04211__57 0.000143189328195689 DOWN -3.8032144113927 0.000219098328729397 Longevity regulating pathway - mammal: ATG5 hsa04022__66 0.000146089588639998 UP 3.79824532511292 0.000223354220548866 cGMP-PKG signaling pathway: PDE3A hsa04621__4 7 8 0.00015129857647505 UP 3.78954942412329 0.00023113010178587 NOD-like receptor signaling pathway: IKBKG CHUK IKBKB hsa04662__32 51 0.000152056836325674 UP 3.78830715255334 0.00023209975260434 B cell receptor signaling pathway: BLNK GRB2 hsa04010__129 0.000159838738878631 UP 3.77588443685387 0.000243780024637133 MAPK signaling pathway: FOS hsa04015__30 0.000160637210904887 UP 3.77464216528392 0.000244799123511989 Rap1 signaling pathway: ITGAL hsa05168__39 40 0.000164686184494631 UP 3.76843080743419 0.000250766078335018 Herpes simplex infection: POU2F3 HCFC2 hsa04622__44 0.000166332502239047 UP 3.76594626429429 0.000253067831341837 RIG-I-like receptor signaling pathway: MAPK8 hsa05164__31 32 33 0.000170515155313011 DOWN -3.75973490644456 0.000259013831015326 Influenza A: NLRP3 PYCARD CASP1 hsa05217__4 0.000170516290029781 DOWN -3.75973490644456 0.000259013831015326 Basal cell carcinoma: PTCH1 hsa05133__73 0.000178297631705111 DOWN -3.74855446231504 0.000270614903048387 Pertussis: FOS hsa05223__23 0.000180071582496254 DOWN -3.74606991917514 0.000273086766352269 Non-small cell lung cancer: CASP9* hsa04010__12 0.000183669382811858 UP 3.74110083289535 0.000278318363147969 MAPK signaling pathway: PLA2G4B hsa04660__34 0.00018549352127139 DOWN -3.73861628975546 0.000280856024551927 T cell receptor signaling pathway: FOS hsa04912__15 0.000190128652795388 DOWN -3.73240493190573 0.000287642301612346 GnRH signaling pathway: CAMK2A hsa04360__131 0.000192013008593786 UP 3.72992038876583 0.000290259407198491 Axon guidance: RAC1**** hsa04370__16 0.000193914905217119 UP 3.72743584562594 0.000292898799761227 VEGF signaling pathway: HSPB1 hsa05321__138 0.000196800970781301 UP 3.7237090309161 0.000297019296464308 Inflammatory bowel disease (IBD): IFNG** hsa05132__13 0.000197771927855778 DOWN -3.72246675934615 0.000298245146421354 Salmonella infection: FOS hsa05200__220 0.000216037633035514 DOWN -3.7001058710871 0.000325529039674203 Pathways in cancer: CSF1R* hsa04620__46 0.000231327049109554 DOWN -3.68271406910785 0.000348288081151323 Toll-like receptor signaling pathway: TNF hsa04920__9 0.000234732850972132 UP 3.678987254398 0.000353132927923647 Adipocytokine signaling pathway: G6PC hsa04740__39 0.000245234725564069 DOWN -3.66780681026848 0.000368636839467909 Olfactory transduction: PRKG1* hsa04933__28 0.000248832197522723 DOWN -3.66407999555864 0.000373745562865865 AGE-RAGE signaling pathway in diabetic complications: VCAM1 hsa04540__11 0.000254938190107651 DOWN -3.65786863770891 0.000382610909913959 Gap junction: C00780 hsa04066__26 0.000259923853505775 UP 3.65289955142912 0.000389782059646729 HIF-1 signaling pathway: C01245 hsa05162__25 70 0.00029041151084514 DOWN -3.62432730532034 0.000434807353687664 Measles: IFNAR1 GNB2L1 hsa05211__31 0.00029041151084514 UP 3.62432730532034 0.000434807353687664 Renal cell carcinoma: SOS1 hsa05160__12 13 14 0.000291810197566465 DOWN -3.62308503375039 0.000436553631550468 Hepatitis C: IKBKG CHUK IKBKB hsa04650__110 111 0.000296044213268042 DOWN -3.61935821904055 0.00044253546279288 Natural killer cell mediated cytotoxicity: ITGAL ITGB2 hsa04727__47 0.000300335717155984 UP 3.61563140433071 0.000448593650664621 GABAergic synapse: CACNA1A* hsa04742__4 0.00030761779941537 DOWN -3.60942004648097 0.000459105516363367 Taste transduction: TRPM5 hsa04650__116 0.000335225691651768 UP 3.58705915822193 0.000499911963979106 Natural killer cell mediated cytotoxicity: FCGR3A hsa04668__102 0.000341667767453538 UP 3.58209007194214 0.000509114777989847 TNF signaling pathway: AKT3 hsa04612__39 0.000343296286134255 UP 3.58084780037219 0.000511136071035076 Antigen processing and presentation: PSME3 hsa04662__29 0.000373880266887978 UP 3.55848691211315 0.000556232004340864 B cell receptor signaling pathway: RAC1 hsa04725__43 0.000391953658137721 DOWN -3.54606419641368 0.000582658958576565 Cholinergic synapse: CREB3 hsa04912__20 0.000393805211691648 DOWN -3.54482192484373 0.000584948610884274 GnRH signaling pathway: PLA2G4B hsa04360__122 0.000403186196184428 DOWN -3.538610566994 0.000598409844099953 Axon guidance: CFL1** hsa04024__2 0.000408914565249329 DOWN -3.53488375228415 0.000606432887216644 cAMP signaling pathway: CACNA1C hsa05150__69 0.000414718884773807 DOWN -3.53115693757431 0.00061455582373027 Staphylococcus aureus infection: FPR2 hsa04920__12 0.000424562439056543 UP 3.52494557972458 0.000628646826625094 Adipocytokine signaling pathway: C00165 hsa04390__78 0.000446996629927373 DOWN -3.51128059245516 0.000661343832782311 Hippo signaling pathway: SOX2 hsa04010__119 0.000455424684100251 UP 3.50631150617537 0.000673283226927122 MAPK signaling pathway: NFATC3 hsa04621__28 0.000499834764584252 UP 3.48146607477643 0.000738356542966831 NOD-like receptor signaling pathway: CASP8 hsa05217__22 0.000502157922418473 UP 3.48022380320649 0.000741205605832137 Basal cell carcinoma: LEF1 hsa05110__17 0.000511551592692113 DOWN -3.4752547169267 0.000754478369441508 Vibrio cholerae infection: C00698* hsa05169__93 0.000521108859675963 UP 3.47028563064691 0.000767971409671478 Epstein-Barr virus infection: PLCG1 hsa05219__12 0.00052594965581781 DOWN -3.46780108750702 0.000774497964954282 Bladder cancer: ERBB2 hsa04931__144 0.000548256322574783 UP 3.45662064337749 0.000806082652674505 Insulin resistance: C00533* hsa05321__94 0.000548256322574783 UP 3.45662064337749 0.000806082652674505 Inflammatory bowel disease (IBD): IL22 hsa05162__81 0.000555885622257895 DOWN -3.45289382866765 0.000816660738250652 Measles: TNFRSF10D hsa04933__52 0.000558450618483884 DOWN -3.45165155709771 0.000819788056352514 AGE-RAGE signaling pathway in diabetic complications: FOXO1 hsa05134__70 0.00056361371441705 UP 3.44916701395781 0.000826721443707757 Legionellosis: IL6 hsa04931__77 0.000571427945249645 UP 3.44544019924797 0.000836896170123701 Insulin resistance: PPP2R4** hsa05130__26 0.000571441078376108 DOWN -3.44544019924797 0.000836896170123701 Pathogenic Escherichia coli infection: CTNNB1 hsa05160__7 0.000576716591699919 DOWN -3.44295565610808 0.000843964545018807 Hepatitis C: IRF3 hsa05016__55 0.000587402513060922 UP 3.43798656982829 0.000858933324545893 Huntington's disease: TGM2 hsa04931__140 0.000612123330415295 DOWN -3.42680612569877 0.000894385488219549 Insulin resistance: G00369 hsa05134__69 0.000614929056536424 UP 3.42556385412882 0.000897786866536084 Legionellosis: IL1B* hsa04725__53 0.000626270812469493 DOWN -3.42059476784903 0.000913635758253243 Cholinergic synapse: CHRNA7 hsa04014__104 0.000640724556562872 DOWN -3.4143834099993 0.000933272435489641 Ras signaling pathway: BRAP* hsa04510__42 0.000640724556562872 DOWN -3.4143834099993 0.000933272435489641 Focal adhesion: BIRC2 hsa04728__61 0.000655486778424031 UP 3.40817205214956 0.00095403536534373 Dopaminergic synapse: KCNJ3 hsa04924__30 0.000664495293585303 UP 3.40444523743972 0.000966398341057882 Renin secretion: PDE3A hsa04727__8 0.000695361818252141 DOWN -3.39202252174025 0.00101050646287376 GABAergic synapse: ADCY1 hsa05134__59 0.000744168122274822 UP 3.37338844819105 0.00108059652376692 Legionellosis: HSPA1A hsa05160__8 0.000747532426891526 DOWN -3.3721461766211 0.00108464357538933 Hepatitis C: NFKB1 hsa04612__18 0.000764566839802185 DOWN -3.36593481877136 0.00110850392900332 Antigen processing and presentation: KIR2DS2 hsa05200__198 0.000768016681124209 UP 3.36469254720142 0.00111264714250762 Pathways in cancer: BCL2L1* hsa05200__199 0.000817856774458789 UP 3.34730074522216 0.00118302762063746 Pathways in cancer: BCL2L1** hsa05220__3 0.000817856774458789 UP 3.34730074522216 0.00118302762063746 Chronic myeloid leukemia: BCL2L1 hsa04150__33 0.00087068380856098 UP 3.3299089432429 0.00125847298175852 mTOR signaling pathway: RPS6 hsa04925__34 0.000874575700051912 DOWN -3.32866667167295 0.00126312662597813 Aldosterone synthesis and secretion: STAR hsa05210__9 11 0.000894278230795136 DOWN -3.32245531382322 0.00129059047286026 Colorectal cancer: SMAD2 SMAD4 hsa04151__26 0.000906296412808457 DOWN -3.31872849911338 0.00130693089767236 PI3K-Akt signaling pathway: RBL2 hsa05016__22 9 0.00092665985875043 UP 3.31251714126364 0.0013352713762209 Huntington's disease: DLG4 HTT hsa04210__10 0.000934923300775756 DOWN -3.31003259812375 0.0013461462698526 Apoptosis: BIRC2 hsa05132__54 0.000947446545736921 UP 3.30630578341391 0.0013631332767532 Salmonella infection: IL1B hsa05164__34 0.000964385985791757 UP 3.30133669713412 0.00138644320375112 Influenza A: IL1B hsa04115__3 0.00101690190132322 UP 3.28642943829476 0.00145970868799566 p53 signaling pathway: GADD45G hsa04923__38 0.00101690190132322 DOWN -3.28642943829476 0.00145970868799566 Regulation of lipolysis in adipocytes: PDE3B hsa05169__83 0.0010259076960951 UP 3.28394489515486 0.00147151187859748 Epstein-Barr virus infection: GSK3B hsa04750__62 0.00103497354456574 UP 3.28146035201497 0.00148338313519377 Inflammatory mediator regulation of TRP channels: TRPM8* hsa04380__20 0.00108626805705543 UP 3.26779536474555 0.00155571469451765 Osteoclast differentiation: MAP2K1 hsa05152__23 0.00110065607885273 DOWN -3.26406855003571 0.00157512016158742 Tuberculosis: PPP3CA hsa05100__15 0.00110549111449129 DOWN -3.26282627846576 0.00158083546737377 Bacterial invasion of epithelial cells: CTNNA1 hsa05161__78 0.00118557155900077 UP 3.24294993334661 0.00169406004514254 Hepatitis B: TNF hsa05134__6 0.00121695924258195 UP 3.23549630392693 0.00173758846262271 Legionellosis: IL1B hsa04024__77 0.00124370007282939 DOWN -3.2292849460772 0.00177442098469736 cAMP signaling pathway: RHOA* hsa05200__216 0.00127650495850432 UP 3.22183131665751 0.00181984280503006 Pathways in cancer: IL6 hsa05200__187 0.00135617999602469 UP 3.20443951467826 0.0019319652862247 Pathways in cancer: WNT16* hsa04066__49 0.00138572980917892 DOWN -3.19822815682852 0.00197256538745999 HIF-1 signaling pathway: EPO hsa04933__78 0.00142809779059399 UP 3.18953225583889 0.00203133667564429 AGE-RAGE signaling pathway in diabetic complications: TGFB1 hsa04010__15 0.00145908826894244 UP 3.18332089798916 0.00207228031545188 MAPK signaling pathway: NFKB1 hsa05133__27 0.00145908826894244 DOWN -3.18332089798916 0.00207228031545188 Pertussis: IRF3 hsa05231__18 0.00147165708946733 DOWN -3.18083635484926 0.00208855262168362 Choline metabolism in cancer: CHKA hsa05134__7 0.00148432561437448 DOWN -3.17835181170937 0.00210494175804502 Legionellosis: IL18 hsa04210__52 0.00149709455576417 DOWN -3.17586726856947 0.00212144846929176 Apoptosis: PARP2 hsa04919__43 0.00157585738494319 UP 3.16096000973011 0.00223137605599718 Thyroid hormone signaling pathway: TBC1D4 hsa04540__10 0.00158934955282215 DOWN -3.15847546659022 0.00224878600131989 Gap junction: C00533 hsa05161__29 0.00168681284757423 UP 3.14108366461096 0.00238489190413241 Hepatitis B: NFKB1 hsa04724__13 0.00175972905492841 UP 3.12866094891149 0.0024861134542936 Glutamatergic synapse: GRM5 hsa04918__14 0.00177469717033854 UP 3.1261764057716 0.00250349548278237 Thyroid hormone synthesis: DUOX2 hsa04930__10 0.00177469717033854 DOWN -3.1261764057716 0.00250349548278237 Type II diabetes mellitus: C00031 hsa04360__123 0.00182020019517241 UP 3.11872277635191 0.00256575856468789 Axon guidance: ENAH hsa04390__17 51 0.00192249056727995 UP 3.1025732459426 0.00270791587400227 Hippo signaling pathway: YWHAQ YAP1 hsa04115__37 0.00195501069323043 DOWN -3.09760415966281 0.0027495996201946 p53 signaling pathway: FAS hsa04623__25 0.00195501069323043 DOWN -3.09760415966281 0.0027495996201946 Cytosolic DNA-sensing pathway: NFKB1* hsa04010__68 0.00203003558565155 UP 3.08642371553329 0.00285298194872047 MAPK signaling pathway: ATF2 hsa05133__24 0.00204706255917478 DOWN -3.0839391723934 0.00287261430073892 Pertussis: NFKB1 hsa05200__196 0.00204706255917478 UP 3.0839391723934 0.00287261430073892 Pathways in cancer: TRAF1 hsa04066__54 0.0020989327155119 UP 3.07648554297372 0.00294320490481109 HIF-1 signaling pathway: SERPINE1 hsa04923__43 0.00216996842777528 UP 3.06654737041414 0.00304054487381786 Regulation of lipolysis in adipocytes: C00219 hsa04360__33 134 0.00217900119173264 DOWN -3.06530509884419 0.00305092640779854 Axon guidance: NCK1 PAK4 hsa04630__33 0.00220630668230586 DOWN -3.06157828413435 0.00308685797174439 Jak-STAT signaling pathway: RAF1 hsa05030__80 81 0.00223392544663706 UP 3.05785146942451 0.00312317404332666 Cocaine addiction: GRIN3A DLG4 hsa04210__3 0.00226186069089257 UP 3.05412465471467 0.0031598782440053 Apoptosis: BCL2L1 hsa04022__60 0.00229011564913621 DOWN -3.05039784000483 0.00319697422342269 cGMP-PKG signaling pathway: TRPC6* hsa05031__101 0.00229960557911879 DOWN -3.04915556843488 0.00320783881452428 Amphetamine addiction: FOS* hsa05166__99 0.00232829190200829 DOWN -3.04542875372504 0.00324544546281422 HTLV-I infection: JUN hsa04015__11 0.00233792659467548 UP 3.04418648215509 0.00325645965262805 Rap1 signaling pathway: RAC1 hsa05200__183 0.00238664998515908 UP 3.03797512430536 0.00332186320156585 Pathways in cancer: BMP2 hsa04933__23 0.00239650551655426 UP 3.03673285273541 0.00333064635029989 AGE-RAGE signaling pathway in diabetic complications: F3 hsa05222__35 0.00239650551655426 UP 3.03673285273541 0.00333064635029989 Small cell lung cancer: NOS2 hsa04064__95 0.00240639828999698 UP 3.03549058116546 0.00334192341973712 NF-kappa B signaling pathway: BCL2L1** hsa04550__101 0.00243630131845719 DOWN -3.03176376645562 0.00337596620750816 Signaling pathways regulating pluripotency of stem cells: ESRRB hsa05200__66 0.00243630131845719 UP 3.03176376645562 0.00337596620750816 Pathways in cancer: CCND1 hsa05205__140 0.00243630131845719 UP 3.03176376645562 0.00337596620750816 Proteoglycans in cancer: MAPK1*** hsa04210__85 0.00252806245866791 DOWN -3.0205833223261 0.00350053747961459 Apoptosis: FASLG* hsa05150__14 0.0025593394313075 UP 3.01685650761626 0.00354123622343652 Staphylococcus aureus infection: FPR1 hsa04210__70 0.00260160592293265 DOWN -3.01188742133647 0.0035970695579032 Apoptosis: CFLAR* hsa05221__5 0.00263371920289987 DOWN -3.00816060662663 0.00363879292812416 Acute myeloid leukemia: SPI1 hsa04010__117 0.0027658283881138 UP 2.99325334778727 0.00381850958212037 MAPK signaling pathway: JUND hsa04024__3 0.00281119228343776 DOWN -2.98828426150748 0.00387828950115973 cAMP signaling pathway: RYR2 hsa05150__13 0.00284565997577795 DOWN -2.98455744679764 0.00392296045083402 Staphylococcus aureus infection: C5AR1 hsa04520__69 0.00285723467172924 DOWN -2.98331517522769 0.00393602928752144 Adherens junction: IQGAP1** hsa04922__24 0.00287513459713253 DOWN -2.9808306320878 0.00395778601319562 Glucagon signaling pathway: PFKL hsa04742__55 0.00290388064627102 UP 2.9783460889479 0.00399162354356579 Taste transduction: P2RX3 hsa04933__56 0.00290396454712849 DOWN -2.9783460889479 0.00399162354356579 AGE-RAGE signaling pathway in diabetic complications: NFATC1 hsa04211__52 0.00291575549935846 DOWN -2.97710381737796 0.00400490101118023 Longevity regulating pathway - mammal: PPARG hsa05142__64 0.00301166766020435 DOWN -2.96716564481838 0.0041336183590387 Chagas disease (American trypanosomiasis): CASP8 hsa04520__44 47 0.00304837054366688 DOWN -2.96343883010854 0.00418094032959859 Adherens junction: ACTB TJP1 hsa04620__86 0.0031609403237773 DOWN -2.95225838597902 0.00433217131172688 Toll-like receptor signaling pathway: IL12A hsa04550__47 0.00319929741523182 UP 2.94853157126918 0.00438154507523367 Signaling pathways regulating pluripotency of stem cells: CTNNB1* hsa04115__16 0.00323807823265423 UP 2.94480475655933 0.00443142680200823 p53 signaling pathway: PPM1D hsa05110__52 0.00335700457203761 UP 2.93362431242981 0.0045908381301737 Vibrio cholerae infection: ADCY3 hsa05142__67 0.00339752199384746 UP 2.92989749771997 0.00464286823741045 Chagas disease (American trypanosomiasis): IFNGR1* hsa05200__48 0.00343848416177956 DOWN -2.92617068301013 0.00469543004359287 Pathways in cancer: MTOR hsa04014__35 0.00349379966158798 DOWN -2.92120159673034 0.00476750149900059 Ras signaling pathway: NFKB1 hsa04066__63 0.00370852002138776 UP 2.90256752318114 0.00504949936245479 HIF-1 signaling pathway: TIMP1* hsa04066__57 0.00370852002138776 UP 2.90256752318114 0.00504949936245479 HIF-1 signaling pathway: TIMP1 hsa04920__5 0.00370852002138776 DOWN -2.90256752318114 0.00504949936245479 Adipocytokine signaling pathway: NFKBIA hsa04360__31 0.00375287750671143 DOWN -2.8988407084713 0.00510619611521417 Axon guidance: CDC42* hsa04912__14 0.00393517071717622 DOWN -2.88393344963193 0.00535035150330978 GnRH signaling pathway: ATF4 hsa04014__65 0.00395071902478571 DOWN -2.88269117806199 0.00536760740966908 Ras signaling pathway: MLLT4* hsa04115__18 0.00412546998451612 UP 2.86902619079257 0.00560098128678165 p53 signaling pathway: CCNG1 hsa04668__48 0.00415798634511402 DOWN -2.86654164765267 0.00563698148807305 TNF signaling pathway: CASP3 hsa04921__67 0.00415798634511402 UP 2.86654164765267 0.00563698148807305 Oxytocin signaling pathway: RYR1 hsa05152__69 0.00420719701410419 DOWN -2.86281483294283 0.00569958413085925 Tuberculosis: HLA-DMA hsa05205__304 0.00427363301318873 DOWN -2.85784574666305 0.00578541529667264 Proteoglycans in cancer: MAPK1***** hsa05211__27 0.0043410189828412 UP 2.85287666038326 0.0058724079688687 Renal cell carcinoma: VEGFA* hsa04014__67 0.00442660547544823 DOWN -2.84666530253352 0.00597957705849548 Ras signaling pathway: RAPGEF5* hsa04915__40 0.00442660547544823 UP 2.84666530253352 0.00597957705849548 Estrogen signaling pathway: CREB3** hsa04014__68 0.00451371839613515 UP 2.84045394468379 0.00608849739148453 Ras signaling pathway: RALGDS* hsa05205__238 0.00451371839613515 UP 2.84045394468379 0.00608849739148453 Proteoglycans in cancer: ITGAV* hsa05100__33 0.00460238154785661 DOWN -2.83424258683405 0.0062036405512357 Bacterial invasion of epithelial cells: DNM1 hsa04150__31 0.00467444442447534 DOWN -2.82927350055426 0.0062962588341141 mTOR signaling pathway: EIF4E hsa04151__27 0.00469261903647579 DOWN -2.82803122898432 0.00631621143949714 PI3K-Akt signaling pathway: FASLG hsa04015__100 101 48 0.00484033468497782 UP 2.81809305642474 0.00651037141952278 Rap1 signaling pathway: PRKCI PARD6A PARD3 hsa04110__43 83 84 85 0.00499224486472669 DOWN -2.80815488386517 0.00670989134536585 Cell cycle: SMC1B SMC3 STAG1 RAD21 hsa04650__40 0.00503088990971321 DOWN -2.80567034072527 0.00675699938552618 Natural killer cell mediated cytotoxicity: TNFRSF10D hsa04620__48 0.0051286885530638 DOWN -2.79945898287554 0.00688343270800491 Toll-like receptor signaling pathway: CD80 hsa04152__63 0.0053294571521393 UP 2.78703626717607 0.00714778728684493 AMPK signaling pathway: PPARG hsa05030__73 0.0055161886226538 DOWN -2.77585582304654 0.00739295179883487 Cocaine addiction: NFKB1 hsa04668__20 0.00568710745851761 DOWN -2.76591765048697 0.00761658939027411 TNF signaling pathway: IKBKG hsa04071__66 0.00579634283863328 UP 2.75970629263723 0.00775735626338456 Sphingolipid signaling pathway: C01245 hsa04024__111 0.00584056410137575 DOWN -2.75722174949734 0.00781097505087903 cAMP signaling pathway: JUN hsa05205__188 0.00586278858448642 UP 2.75597947792739 0.00783512073275248 Proteoglycans in cancer: TNF hsa05134__71 0.00599774369265982 UP 2.74852584850771 0.00800977995629553 Legionellosis: CXCL8 hsa05205__451 0.00620542810846009 DOWN -2.73734540437819 0.00828124958508275 Proteoglycans in cancer: KDR** hsa04950__1 0.00639544832887565 DOWN -2.72740723181861 0.00852877743786895 Maturity onset diabetes of the young: HNF1B hsa04917__48 0.00644376418571813 UP 2.72492268867872 0.00858102969876992 Prolactin signaling pathway: CCND2 hsa05160__70 0.00644376418571813 DOWN -2.72492268867872 0.00858102969876992 Hepatitis C: CDKN1A hsa04064__142 0.00671541879612907 DOWN -2.7112577014093 0.00893645319966468 NF-kappa B signaling pathway: NFKB2* hsa04350__12 0.00679127166181607 UP 2.70753088669946 0.00903099748942137 TGF-beta signaling pathway: ACVR2A hsa04930__13 0.00689360633441277 UP 2.70256180041967 0.00916059851652164 Type II diabetes mellitus: C00162 hsa04919__89 0.0069194055051061 DOWN -2.70131952884973 0.00918838370607375 Thyroid hormone signaling pathway: CASP9 hsa04742__8 0.00699731168115046 DOWN -2.69759271413988 0.00928527446954923 Taste transduction: PLCB2 hsa04742__23 45 0.00707601018288576 UP 2.69386589943004 0.00937648837548091 Taste transduction: PKD1L3 PKD2L1 hsa04062__53 0.00707603007793078 DOWN -2.69386589943004 0.00937648837548091 Chemokine signaling pathway: NFKB1 hsa04970__21 0.00712894130879093 DOWN -2.69138135629015 0.0094399441291178 Salivary secretion: ITPR1 hsa05223__21 0.00734415590337741 UP 2.68144318373057 0.0097180767200325 Non-small cell lung cancer: FOXO3* hsa04510__19 23 0.00742635231982461 UP 2.67771636902073 0.00981992681840285 Focal adhesion: VCL TLN1 hsa04115__56 0.00820407021260309 UP 2.64417503663216 0.010840680681773 p53 signaling pathway: SESN3 hsa04932__138 0.00832528721817372 DOWN -2.63920595035238 0.0109931234595562 Non-alcoholic fatty liver disease (NAFLD): CEBPA hsa04115__50 0.00866693720476727 UP 2.62554096308296 0.0114362184043242 p53 signaling pathway: RCHY1 hsa05321__83 0.00902106424513858 DOWN -2.61187597581354 0.0118951436607827 Inflammatory bowel disease (IBD): IL2 hsa05161__130 0.00905388961692266 DOWN -2.61063370424359 0.0119300551123406 Hepatitis B: FASLG* hsa05133__96 0.0092196214478277 UP 2.60442234639386 0.0121399220045328 Pertussis: IL1B hsa04540__21 0.00925309088374704 UP 2.60318007482391 0.0121754606236419 Gap junction: C03758 hsa04620__77 0.00932035520847473 UP 2.60069553168402 0.0122553865897299 Toll-like receptor signaling pathway: CXCL9 hsa05205__145 0.00969816371806019 UP 2.5870305444146 0.0127432514868777 Proteoglycans in cancer: PXN hsa04066__62 0.0106839954941459 DOWN -2.55348921202603 0.014028810295947 HIF-1 signaling pathway: NPPA hsa04071__65 0.0111500467273537 UP 2.53858195318667 0.0146305431569117 Sphingolipid signaling pathway: BAX* hsa04650__15 0.0115930324690467 DOWN -2.52491696591725 0.0152011919116111 Natural killer cell mediated cytotoxicity: TNF hsa04210__71 0.0116752324008394 DOWN -2.52243242277736 0.0152982996381989 Apoptosis: GADD45G hsa04742__34 0.0117579463148386 UP 2.51994787963746 0.0153959450352486 Taste transduction: GRM1 hsa04510__19 26 0.0118411849306391 UP 2.51746333649757 0.0154941410060383 Focal adhesion: VCL ACTN4 hsa05200__222 0.0120940365530451 DOWN -2.51000970707789 0.0158139837739538 Pathways in cancer: CASP9* hsa04727__49 0.0123083897217013 UP 2.50379834922815 0.0160830766947682 GABAergic synapse: GABRR3 hsa05205__144 0.0123950689997752 UP 2.50131380608826 0.0161850831484208 Proteoglycans in cancer: NUDT16L1 hsa05205__256 0.0124386110455172 DOWN -2.50007153451831 0.0162193963598382 Proteoglycans in cancer: ACTB hsa05211__42 0.0124386110455172 UP 2.50007153451831 0.0162193963598382 Renal cell carcinoma: SLC2A1* hsa05168__138 0.0127472166316009 UP 2.49137563352868 0.0166102774277241 Herpes simplex infection: CHUK hsa04930__7 0.0130625792856028 DOWN -2.48267973253906 0.0170094154384253 Type II diabetes mellitus: C00002 hsa04931__135 0.0132458677931581 UP 2.47771064625927 0.0172361396006538 Insulin resistance: SREBF1** hsa05152__112 0.0135250641561869 UP 2.47025701683959 0.0175872633560382 Tuberculosis: IFNGR1 hsa05162__28 34 0.0137140717652395 UP 2.4652879305598 0.0178207059798652 Measles: IRF9 STAT1 hsa05217__3 0.0138573545937705 DOWN -2.46156111584996 0.0179944500910123 Basal cell carcinoma: GLI1 hsa03320__65 0.014050453692903 UP 2.45659202957017 0.0182200155203346 PPAR signaling pathway: ME1 hsa05162__23 0.014050453692903 DOWN -2.45659202957017 0.0182200155203346 Measles: IRF3 hsa05205__109 0.0142459237936344 UP 2.45162294329038 0.0184607522815442 Proteoglycans in cancer: SMAD2 hsa05142__44 0.014644074085994 UP 2.4416847707308 0.01896362178331 Chagas disease (American trypanosomiasis): PLCB1 hsa04310__22 0.014846774792719 DOWN -2.43671568445102 0.0192128717875476 Wnt signaling pathway: ROCK2 hsa04920__31 0.0149490921678547 UP 2.43423114131112 0.0193319643381961 Adipocytokine signaling pathway: AGRP hsa04210__50 0.0151555341567301 DOWN -2.42926205503134 0.0195854530127207 Apoptosis: SPTA1 hsa04360__35 0.0154171142976164 DOWN -2.4230506971816 0.0199097991513548 Axon guidance: ROCK1* hsa04151__96 0.0156292312856528 DOWN -2.41808161090181 0.0201698664737236 PI3K-Akt signaling pathway: BCL2 hsa04621__33 35 0.0161159060909861 DOWN -2.40690116677229 0.0207836565167899 NOD-like receptor signaling pathway: NLRC4 PYCARD hsa05162__13 0.0161707948453556 DOWN -2.40565889520234 0.0208401395846524 Measles: IRF7 hsa05166__74 0.0163364481553269 DOWN -2.4019320804925 0.0210391953967507 HTLV-I infection: NFKB1 hsa04930__8 0.0164477103053037 DOWN -2.39944753735261 0.0211679778518258 Type II diabetes mellitus: C00022 hsa04950__11 0.0167287826757247 DOWN -2.39323617950287 0.0215149778560483 Maturity onset diabetes of the young: HNF4G hsa05166__34 35 36 0.0170715800067193 DOWN -2.38578255008319 0.0219258994946182 HTLV-I infection: MYC TRRAP KAT5 hsa04917__31 0.017071629037055 DOWN -2.38578255008319 0.0219258994946182 Prolactin signaling pathway: GALT hsa05220__22 0.0175383392438269 UP 2.37584437752361 0.0225099313108953 Chronic myeloid leukemia: CDKN1B hsa04360__6 0.0176567501807507 UP 2.37335983438372 0.022646439310328 Axon guidance: MAPK1 hsa04621__21 30 0.0177162179797588 UP 2.37211756281377 0.022707212540223 NOD-like receptor signaling pathway: NLRP3 PYCARD hsa04621__42 0.0185054211215328 UP 2.35596803240446 0.0237025809729789 NOD-like receptor signaling pathway: MAPK8 hsa04630__35 0.0186918552894185 DOWN -2.35224121769462 0.0239250654555977 Jak-STAT signaling pathway: MTOR hsa05160__22 23 0.0199772622755837 UP 2.32739578629568 0.0255355617794706 Hepatitis C: STAT1 IRF9 hsa05205__337 0.0199772622755837 DOWN -2.32739578629568 0.0255355617794706 Proteoglycans in cancer: CTNNB1** hsa04064__137 0.0200435106374422 UP 2.32615351472574 0.025602825620499 NF-kappa B signaling pathway: ICAM1 hsa05211__23 0.0206484251441233 UP 2.31497307059621 0.0263576024767716 Renal cell carcinoma: PDGFB hsa05166__5 0.0211298596248061 UP 2.30627716960658 0.0269538399423018 HTLV-I infection: SLC2A1 hsa05169__117 0.0215502719249927 DOWN -2.2988235401869 0.0274714796113034 Epstein-Barr virus infection: CDKN1A hsa05133__60 0.0219061598358705 DOWN -2.29261218233717 0.027906219885831 Pertussis: C5 hsa04932__14 0.0219779478681359 DOWN -2.29136991076722 0.0279787019269832 Non-alcoholic fatty liver disease (NAFLD): PKLR hsa04071__57 0.0227812226328246 DOWN -2.2777049234978 0.0289816637285562 Sphingolipid signaling pathway: BAX hsa05145__13 0.023917636280133 DOWN -2.2590708499486 0.0304067919961907 Toxoplasmosis: GNAI1 hsa04666__23 0.0244645774072881 UP 2.25037494895897 0.0310810959758583 Fc gamma R-mediated phagocytosis: RPS6KB1 hsa05212__29 0.0246228235504107 DOWN -2.24789040581907 0.0312610036832579 Pancreatic cancer: VEGFA hsa05032__25 0.0255091218836806 DOWN -2.23422541854966 0.0323643754351357 Morphine addiction: C00575* hsa04550__69 0.0256731985296158 DOWN -2.23174087540976 0.0325505668266857 Signaling pathways regulating pluripotency of stem cells: ID1 hsa04062__60 0.0260040920272095 UP 2.22677178912998 0.0329478684552439 Chemokine signaling pathway: GSK3A hsa04210__69 0.0260873892308374 UP 2.22552951756003 0.0330311350166735 Apoptosis: PTPN13 hsa04932__55 0.0265920317720128 DOWN -2.21807588814035 0.0336474260603448 Non-alcoholic fatty liver disease (NAFLD): CASP3 hsa04360__18 0.0266769535141122 UP 2.2168336165704 0.033732163965691 Axon guidance: PTK2 hsa04014__103 0.0269331255360177 DOWN -2.21310680186056 0.0339874700350418 Ras signaling pathway: KSR2 hsa04924__58 0.0269331255360177 DOWN -2.21310680186056 0.0339874700350418 Renin secretion: PPP3CA hsa05031__59 0.0269331255360177 DOWN -2.21310680186056 0.0339874700350418 Amphetamine addiction: PPP3CA hsa05321__123 0.0277144234481175 UP 2.20192635773104 0.0349499339993374 Inflammatory bowel disease (IBD): IL5* hsa05211__2 0.028246080396198 DOWN -2.19447272831135 0.0355965023906479 Renal cell carcinoma: TGFB1 hsa05162__44 0.0283355389890132 DOWN -2.19323045674141 0.03568530680989 Measles: PRKCQ hsa05205__45 46 0.0286053808803228 UP 2.18950364203157 0.036001011837995 Proteoglycans in cancer: PAK1 FLNA hsa04917__45 0.0288774330232368 UP 2.18577682732173 0.0363190740633614 Prolactin signaling pathway: SLC2A2 hsa04152__49 0.0303662990601785 UP 2.16590048220257 0.0381660708589133 AMPK signaling pathway: GYS1 hsa04724__36 0.0308448926956744 DOWN -2.15968912435284 0.0387416800636178 Glutamatergic synapse: TRPC1 hsa04722__35 0.0309413846247599 DOWN -2.15844685278289 0.038836914969889 Neurotrophin signaling pathway: FOXO3 hsa04710__11 0.0321196465536873 DOWN -2.14353959394353 0.0402889291551258 Circadian rhythm: CRY1 hsa04014__76 0.032319716132538 UP 2.14105505080363 0.0405128396351159 Ras signaling pathway: RALBP1* hsa04728__71 72 0.0331307069380324 DOWN -2.13111687824406 0.041474082835818 Dopaminergic synapse: CLOCK ARNTL hsa05200__52 0.0331307069380324 UP 2.13111687824406 0.041474082835818 Pathways in cancer: CDKN1B hsa04010__63 0.0335426922509016 UP 2.12614779196427 0.0419618633418403 MAPK signaling pathway: MAX hsa04390__79 0.0336463706749183 DOWN -2.12490552039432 0.042063559879023 Hippo signaling pathway: SNAI2 hsa05166__26 0.0338545499727292 UP 2.12242097725443 0.0422956777917275 HTLV-I infection: NFATC1 hsa05168__92 93 0.0362181446260183 DOWN -2.09509100271559 0.0452185340546767 Herpes simplex infection: IRF9 STAT1 hsa04068__40 0.036886666795589 DOWN -2.08763737329591 0.0459615695682439 FoxO signaling pathway: CCND1 hsa04670__28 41 49 0.036886666795589 DOWN -2.08763737329591 0.0459615695682439 Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1 hsa05132__86 0.036886666795589 DOWN -2.08763737329591 0.0459615695682439 Salmonella infection: MYH9 hsa05200__193 0.0372248502811461 DOWN -2.08391055858607 0.0463522158239056 Pathways in cancer: NOS2 hsa05161__30 0.038604101050969 DOWN -2.06900329974671 0.0480378184601131 Hepatitis B: MYC hsa04622__11 0.039428543505676 UP 2.06030739875708 0.0489988315126754 RIG-I-like receptor signaling pathway: IRF7 hsa05220__19 41 0.039428543505676 DOWN -2.06030739875708 0.0489988315126754 Chronic myeloid leukemia: SMAD4 SMAD3 hsa04520__34 0.0396667948989681 DOWN -2.05782285561719 0.0492623315367885 Adherens junction: RHOA hsa04062__43 0.041245639892831 DOWN -2.04167332520787 0.0511892717031898 Chemokine signaling pathway: STAT1 hsa04728__64 0.0413692616183497 DOWN -2.04043105363793 0.0513088069840786 Dopaminergic synapse: SCN1A hsa04621__44 0.0417420111379916 UP 2.03670423892809 0.0517369649922733 NOD-like receptor signaling pathway: MAPK14 hsa05010__49 0.0421175998751557 DOWN -2.03297742421825 0.0521680752573616 Alzheimer's disease: EIF2AK3 hsa04064__52 0.0423695777917196 DOWN -2.03049288107835 0.0524456104549678 NF-kappa B signaling pathway: TRAF1 hsa04340__51 0.0430051070349748 UP 2.02428152322862 0.0531972324678852 Hedgehog signaling pathway: CCND1* hsa04340__31 0.0437783600582856 DOWN -2.01682789380894 0.0541181174667886 Hedgehog signaling pathway: GLI1*** hsa04920__1 0.0458979697444668 UP 1.99695154868978 0.0567010421761033 Adipocytokine signaling pathway: C00195 hsa04933__61 0.0461689010063675 UP 1.99446700554989 0.0569982687194248 AGE-RAGE signaling pathway in diabetic complications: MMP2 hsa04010__54 0.0463048708757305 DOWN -1.99322473397994 0.0571285964382782 MAPK signaling pathway: NR4A1 hsa04917__47 0.0498152702011986 UP 1.96216794473127 0.0614192209370421 Prolactin signaling pathway: INS hsa04520__9 57 0.0527818572820778 DOWN -1.93732251333233 0.065034170382311 Adherens junction: LEF1 CTNNB1 hsa05164__77 0.0537001130944954 DOWN -1.92986888391265 0.0661222231353584 Influenza A: CASP9 hsa05120__50 0.0541642196644762 DOWN -1.9261420692028 0.0666500122786842 Epithelial cell signaling in Helicobacter pylori infection: EGFR hsa04015__17 0.0543196637517808 UP 1.92489979763286 0.0667975446266991 Rap1 signaling pathway: ACTB hsa04340__26 0.0551024776299928 UP 1.91868843978312 0.0677158636146216 Hedgehog signaling pathway: PTCH1** hsa04530__7 52 0.0554182255921433 UP 1.91620389664323 0.0680149221996325 Tight junction: PARD6A MPP5 hsa05215__9 0.0554182255921433 UP 1.91620389664323 0.0680149221996325 Prostate cancer: CDKN1B hsa04932__28 0.0555766641229821 UP 1.91496162507328 0.0681648511012294 Non-alcoholic fatty liver disease (NAFLD): GSK3A hsa05321__19 0.0560542457411806 UP 1.91123481036344 0.0687057584785899 Inflammatory bowel disease (IBD): TNF hsa03320__56 0.0563745283712768 UP 1.90875026722355 0.0690532847520399 PPAR signaling pathway: FADS2 hsa05016__12 0.0571819051947036 DOWN -1.90253890937381 0.0699966122871974 Huntington's disease: REST hsa04950__21 0.05767093138318 UP 1.89881209466397 0.0705492708782521 Maturity onset diabetes of the young: PKLR hsa04540__18 19 0.0584936987618541 DOWN -1.89260073681424 0.0715092127348887 Gap junction: GJA1 GJA1*** hsa04210__102 0.0594938651534571 DOWN -1.88514710739455 0.0726846375964538 Apoptosis: PIDD1 hsa05215__46 0.0596619311922116 DOWN -1.88390483582461 0.0728426047499451 Prostate cancer: MTOR hsa04152__38 0.0611923114551572 DOWN -1.87272439169508 0.0746625670287275 AMPK signaling pathway: PFKL hsa05016__52 0.0629307368138281 DOWN -1.86030167599561 0.0766840820189255 Huntington's disease: CASP3 hsa05217__5 0.0629307368138281 DOWN -1.86030167599561 0.0766840820189255 Basal cell carcinoma: BMP2 hsa05200__184 0.0634601541304232 UP 1.85657486128577 0.0772790859436586 Pathways in cancer: GLI1 hsa05321__95 0.0636374422474714 DOWN -1.85533258971583 0.0774447888490925 Inflammatory bowel disease (IBD): SMAD2 hsa05133__94 0.0650705256607146 UP 1.84539441715625 0.0791375519200535 Pertussis: IL12A hsa05200__209 0.0682042967253029 UP 1.82427580046715 0.0828951316603131 Pathways in cancer: FIGF** hsa04950__7 0.0683924355401027 UP 1.8230335288972 0.0830700623011331 Maturity onset diabetes of the young: FOXA3 hsa04151__4 0.0685810007706683 UP 1.82179125732726 0.0832452845271872 PI3K-Akt signaling pathway: RPS6 hsa04360__58 0.0691492617060905 DOWN -1.81806444261742 0.0838808668468328 Axon guidance: PLXNC1 hsa05200__121 122 0.070490254502614 DOWN -1.80936854162779 0.0853972844683506 Pathways in cancer: SMAD2 SMAD4 hsa05212__38 39 0.070490254502614 DOWN -1.80936854162779 0.0853972844683506 Pancreatic cancer: SMAD2 SMAD4 hsa04623__17 0.0706835548885898 DOWN -1.80812627005784 0.0855762884250389 Cytosolic DNA-sensing pathway: NFKB1 hsa05211__41 0.0714611084713391 DOWN -1.80315718377805 0.0864619593159344 Renal cell carcinoma: PDGFB* hsa04727__26 0.071656588263731 DOWN -1.80191491220811 0.0864757413921327 GABAergic synapse: KCNJ6 hsa05032__81 0.071656588263731 DOWN -1.80191491220811 0.0864757413921327 Morphine addiction: KCNJ6 hsa05032__91 0.071656588263731 DOWN -1.80191491220811 0.0864757413921327 Morphine addiction: KCNJ6** hsa05032__85 0.071656588263731 DOWN -1.80191491220811 0.0864757413921327 Morphine addiction: KCNJ6* hsa05132__8 0.0734356939211566 UP 1.79073446807858 0.088565897867685 Salmonella infection: TJP1 hsa05016__48 0.074036697088633 UP 1.78700765336874 0.0891762524548342 Huntington's disease: HIP1 hsa05016__46 0.074036697088633 UP 1.78700765336874 0.0891762524548342 Huntington's disease: HTT** hsa05166__39 0.0756590487120344 UP 1.77706948080917 0.0910719747148703 HTLV-I infection: RRAS2 hsa04925__33 0.0760691380254552 UP 1.77458493766927 0.0915069848590463 Aldosterone synthesis and secretion: CYP11B2 hsa05164__47 0.0766876701713642 DOWN -1.77085812295943 0.0921920231938537 Influenza A: CIITA hsa05223__7 0.0768947564574936 UP 1.76961585138948 0.092381871728664 Non-small cell lung cancer: FOXO3 hsa04350__32 0.0777276642888291 UP 1.7646467651097 0.0933228633857571 TGF-beta signaling pathway: RPS6KB1 hsa04310__20 0.0820030714616126 UP 1.73980133371076 0.0983932128201596 Wnt signaling pathway: MAPK8 hsa04014__45 0.0831012072941563 UP 1.73358997586102 0.0996472038964388 Ras signaling pathway: RAB5A hsa04066__60 0.0837657877684826 DOWN -1.72986316115118 0.100380047970012 HIF-1 signaling pathway: NOS3 hsa05152__13 0.083988268518078 DOWN -1.72862088958123 0.10058250895186 Tuberculosis: LAMP1 hsa04520__73 0.0851078574191218 DOWN -1.7224095317315 0.101858384771038 Adherens junction: PARD3 hsa05140__21 0.0857853834540678 DOWN -1.71868271702166 0.102603905480709 Leishmaniasis: NFKB1 hsa04064__130 0.0862394841414094 DOWN -1.71619817388176 0.103081419021443 NF-kappa B signaling pathway: TNF* hsa04913__45 0.0866955245289253 UP 1.71371363074187 0.103560642460172 Ovarian steroidogenesis: ACOT2 hsa05200__75 0.0887718563944298 DOWN -1.70253318661235 0.10597351852931 Pathways in cancer: MAPK8 hsa04152__82 0.0890050129812562 DOWN -1.7012909150424 0.106184393264622 AMPK signaling pathway: HMGCR hsa04670__18 0.0892386019350793 DOWN -1.70004864347245 0.106395515885796 Leukocyte transendothelial migration: CDH5 hsa04726__39 0.0904143316445838 DOWN -1.69383728562272 0.107728934153566 Serotonergic synapse: CACNA1C hsa04742__47 0.0954888667476278 DOWN -1.66774958265383 0.113703156285673 Taste transduction: GABRA1 hsa04014__64 0.0974810122269647 DOWN -1.65781141009426 0.116001787190923 Ras signaling pathway: PIK3R5* hsa04210__105 0.0992512643776234 UP 1.64911550910463 0.11803362390225 Apoptosis: ACTB hsa04024__92 0.100531365326948 UP 1.64290415125489 0.119480351327852 cAMP signaling pathway: GRIN3A hsa04213__62 0.102345575261232 UP 1.63420825026526 0.12155963079384 Longevity regulating pathway - multiple species: CAT* hsa04670__10 0.105516163330828 DOWN -1.6193009914259 0.125246286101469 Leukocyte transendothelial migration: BCAR1 hsa04115__9 0.106320864548493 DOWN -1.61557417671606 0.126121783135492 p53 signaling pathway: RPRM hsa04210__72 0.106590176908238 UP 1.61433190514611 0.126361477861564 Apoptosis: BCL2A1 hsa04064__53 0.10713042356401 DOWN -1.61184736200622 0.126921857425457 NF-kappa B signaling pathway: CXCL8 hsa04976__41 0.107944858390925 DOWN -1.60812054729638 0.127806168189381 Bile secretion: CYP7A1 hsa04014__100 0.108490532609534 DOWN -1.60563600415648 0.128371354391256 Ras signaling pathway: REL hsa04915__28 0.110417597459685 DOWN -1.59694010316685 0.130569330161578 Estrogen signaling pathway: KCNJ3 hsa05215__30 0.114352764200041 UP 1.5795483011876 0.135137637693005 Prostate cancer: TP53 hsa04660__30 0.117812893581038 DOWN -1.56464104234823 0.139051775778122 T cell receptor signaling pathway: CD40LG hsa04730__8 0.117812893581038 DOWN -1.56464104234823 0.139051775778122 Long-term depression: GNA13* hsa05160__55 0.123761707232484 UP 1.53979561094929 0.145981323220237 Hepatitis C: MAPK14 hsa04014__61 0.124065192309651 DOWN -1.53855333937934 0.14624748829977 Ras signaling pathway: RAP1A hsa05014__51 0.124369257758152 UP 1.5373110678094 0.146514003340168 Amyotrophic lateral sclerosis (ALS): DERL1 hsa04330__12 0.127441973121414 DOWN -1.52488835210993 0.150039766600963 Notch signaling pathway: HES1 hsa04727__17 37 0.129313755671662 UP 1.51743472269025 0.152148119541048 GABAergic synapse: GABRA1 GPHN hsa04213__52 0.129627784832467 DOWN -1.5161924511203 0.152422157509515 Longevity regulating pathway - multiple species: SOD2 hsa04919__11 0.136687258410876 UP 1.48886247658147 0.160622488151367 Thyroid hormone signaling pathway: CTNNB1 hsa04662__27 0.138002090850041 DOWN -1.48389339030168 0.162066205442017 B cell receptor signaling pathway: NFATC1 hsa04670__86 0.141331811819623 DOWN -1.47147067460221 0.165872875958195 Leukocyte transendothelial migration: ACTB hsa05031__8 0.144039602012455 DOWN -1.46153250204263 0.168945325955932 Amphetamine addiction: DRD1 hsa04520__7 68 0.144381039627801 DOWN -1.46029023047268 0.169240158116431 Adherens junction: CDH1 CTNNB1 hsa04550__60 0.144722931710874 DOWN -1.45904795890274 0.169535155040357 Signaling pathways regulating pluripotency of stem cells: MAPK14 hsa04024__59 0.147133569218486 DOWN -1.45035205791311 0.172251698792234 cAMP signaling pathway: MLLT4 hsa04810__21 82 0.14782793113555 DOWN -1.44786751477321 0.172956838483001 Regulation of actin cytoskeleton: CFL1 ACTB hsa04151__101 0.149926043096328 UP 1.44041388535353 0.175302448648413 PI3K-Akt signaling pathway: PKN3 hsa04115__23 0.151337352995845 UP 1.43544479907374 0.176842590969647 p53 signaling pathway: PTEN hsa04622__9 35 0.153831466421013 UP 1.42674889808412 0.17953374248763 RIG-I-like receptor signaling pathway: IRF3 PIN1 hsa04910__18 0.153831466421013 DOWN -1.42674889808412 0.17953374248763 Insulin signaling pathway: LIPE hsa04932__97 0.15454977816311 UP 1.42426435494422 0.1802601074913 Non-alcoholic fatty liver disease (NAFLD): TNF* hsa04921__41 0.155270635145246 DOWN -1.42177981180433 0.180988538112852 Oxytocin signaling pathway: PTGS2 hsa04380__16 0.156720003026778 UP 1.41681072552454 0.182564715243222 Osteoclast differentiation: NFKB1 hsa04360__20 0.157448522986033 DOWN -1.41432618238465 0.183299736487457 Axon guidance: ROCK1 hsa04115__27 0.15928104740069 UP 1.40811482453491 0.185318320783837 p53 signaling pathway: THBS1 hsa04064__136 0.159649480967049 DOWN -1.40687255296496 0.185632038822454 NF-kappa B signaling pathway: TNFSF13B* hsa05200__186 0.160388281243687 UP 1.40438800982507 0.186375745489727 Pathways in cancer: PTCH1* hsa04010__86 0.16639197723692 UP 1.38451166470592 0.193232710276992 MAPK signaling pathway: MAP4K2 hsa04961__20 0.166772637200875 UP 1.38326939313597 0.193555148425228 Endocrine and other factor-regulated calcium reabsorption: CALB1* hsa04620__39 0.168302364985341 UP 1.37830030685618 0.195209965313245 Toll-like receptor signaling pathway: IL6 hsa04630__34 0.169071113343043 DOWN -1.37581576371629 0.195980642795545 Jak-STAT signaling pathway: AOX1 hsa05164__41 42 0.169456473918585 DOWN -1.37457349214634 0.196306235815672 Influenza A: STAT1 IRF9 hsa04360__40 139 0.171004504527852 DOWN -1.36960440586655 0.197977488606183 Axon guidance: UNC5D DCC hsa04668__141 0.172954405853875 DOWN -1.36339304801682 0.200111655541522 TNF signaling pathway: JUN* hsa04666__50 52 0.174526258000186 UP 1.35842396173703 0.201806054635292 Fc gamma R-mediated phagocytosis: DNM2 AMPH hsa04917__33 0.176108751330829 UP 1.35345487545724 0.203510666513302 Prolactin signaling pathway: CSN2 hsa04724__65 0.176505644244434 DOWN -1.3522126038873 0.203719196186161 Glutamatergic synapse: GRM3 hsa04152__15 0.176506041187371 DOWN -1.3522126038873 0.203719196186161 AMPK signaling pathway: FOXO1 hsa04610__45 0.177302624288971 DOWN -1.3497280607474 0.204512971785743 Complement and coagulation cascades: C4A hsa04917__46 0.18173174663382 DOWN -1.33606307347799 0.209493222039845 Prolactin signaling pathway: GCK hsa04630__7 0.185004121464485 UP 1.32612490091841 0.213134729755835 Jak-STAT signaling pathway: BCL2 hsa05162__27 28 0.185828985579784 DOWN -1.32364035777852 0.213953838176724 Measles: STAT1 IRF9 hsa04064__128 0.186242435849383 UP 1.32239808620857 0.214298552946105 NF-kappa B signaling pathway: IL1B* hsa04064__129 0.193375430262842 DOWN -1.30127946951947 0.222369910320612 NF-kappa B signaling pathway: PTGS2 hsa04211__23 0.196370154791809 DOWN -1.29258356852984 0.225675547922819 Longevity regulating pathway - mammal: SOD2 hsa04330__19 0.198529949925407 UP 1.28637221068011 0.228018200433887 Notch signaling pathway: DTX2 hsa04340__32 0.198963985327752 DOWN -1.28512993911016 0.228377109609557 Hedgehog signaling pathway: PTCH1*** hsa05166__33 0.199315682431249 UP 1.2068668302035 0.228641127770645 HTLV-I infection: HLA-A hsa05161__44 0.201144568220743 UP 1.27891858126042 0.230598318295775 Hepatitis B: CXCL8 hsa05020__62 0.204226598977249 DOWN -1.2702226802708 0.233988889925762 Prion diseases: NOTCH1 hsa05152__126 0.207342844677285 UP 1.26152677928117 0.237414506489103 Tuberculosis: NOS2 hsa04010__88 92 0.208688887726048 DOWN -1.25779996457133 0.238810243628041 MAPK signaling pathway: ECSIT TRAF6 hsa04670__14 0.210041252143147 UP 1.25407314986148 0.240211511124147 Leukocyte transendothelial migration: SIPA1 hsa03320__41 0.212309269642199 DOWN -1.24786179201175 0.242657614147015 PPAR signaling pathway: ANGPTL4 hsa04024__109 0.212764988218862 UP 1.2466195204418 0.243030646117472 cAMP signaling pathway: BDNF hsa04919__101 0.218288784196764 DOWN -1.23171226160244 0.24918871537407 Thyroid hormone signaling pathway: NOTCH1 hsa04151__37 0.220620524412249 DOWN -1.2255009037527 0.251697611032554 PI3K-Akt signaling pathway: G6PC hsa04152__89 0.221089007955284 UP 1.22425863218276 0.252079032735424 AMPK signaling pathway: CFTR hsa04621__30 32 0.221558204176942 DOWN -1.22301636061281 0.252460803910536 NOD-like receptor signaling pathway: PYCARD CASP1 hsa05130__28 0.222498736090375 DOWN -1.22053181747292 0.253378863705343 Pathogenic Escherichia coli infection: ROCK1 hsa05142__36 0.223442123004455 DOWN -1.21804727433302 0.254299060645288 Chagas disease (American trypanosomiasis): SMAD2 hsa05321__81 0.226766500881562 UP 1.20935137334339 0.257926304574125 Inflammatory bowel disease (IBD): IL13 hsa04210__62 0.227244276770022 UP 1.20810910177345 0.258313367241907 Apoptosis: TP53AIP1 hsa04072__27 0.22820198052873 DOWN -1.20562455863355 0.259088532576123 Phospholipase D signaling pathway: C01245 hsa04210__31 32 33 0.22820198052873 DOWN -1.20562455863355 0.259088532576123 Apoptosis: TRAF2 RIPK1 TRADD hsa04910__57 0.229162555835346 UP 1.20314001549366 0.259865082929761 Insulin signaling pathway: GCK hsa05231__38 0.229162555835346 UP 1.20314001549366 0.259865082929761 Choline metabolism in cancer: RPS6KB1 hsa04360__21 0.235967206491946 UP 1.1857482135144 0.267420012664878 Axon guidance: PAK4 hsa04020__16 0.241413087221048 DOWN -1.17208322624498 0.273262163185752 Calcium signaling pathway: C06124 hsa04380__68 0.241413087221048 DOWN -1.17208322624498 0.273262163185752 Osteoclast differentiation: TGFBR1 hsa03320__30 0.245428902254784 UP 1.16214505368541 0.277640522177447 PPAR signaling pathway: LPL hsa04071__69 0.245934154565101 DOWN -1.16090278211546 0.278044690991471 Sphingolipid signaling pathway: RAC1 hsa04390__5 0.246440135663482 DOWN -1.15966051054551 0.278449197180808 Hippo signaling pathway: SAV1 hsa04024__115 0.246946845819174 UP 1.15841823897557 0.278854040441243 cAMP signaling pathway: F2R hsa05152__20 0.252054058408699 UP 1.1459955232761 0.284450195645613 Tuberculosis: FCGR1A hsa04340__20 22 0.261431761276787 DOWN -1.12363463501705 0.294679231817086 Hedgehog signaling pathway: GLI1 SUFU* hsa04350__44 45 0.261431761276787 DOWN -1.12363463501705 0.294679231817086 TGF-beta signaling pathway: TGFBR2 TGFBR1 hsa04024__21 0.268352746072261 DOWN -1.10748510460774 0.302117920832701 cAMP signaling pathway: AKT3 hsa04068__39 0.268352746072261 UP 1.10748510460774 0.302117920832701 FoxO signaling pathway: CCNB3 hsa05145__23 0.271589122907215 UP 1.10003147518806 0.305578420324945 Toxoplasmosis: CIITA hsa05200__211 0.272131107024787 UP 1.09878920361811 0.30600499706737 Pathways in cancer: CXCL8 hsa04310__35 0.279244291012016 UP 1.0826396732088 0.313815803116972 Wnt signaling pathway: JUN hsa05200__146 147 0.284242006857487 DOWN -1.07145922907928 0.318860137841921 Pathways in cancer: RARB RXRA hsa05222__14 15 0.284242006857487 DOWN -1.07145922907928 0.318860137841921 Small cell lung cancer: RXRA RARB hsa05223__29 34 0.284242006857487 DOWN -1.07145922907928 0.318860137841921 Non-small cell lung cancer: RARB RXRA hsa04310__16 0.285361061349765 UP 1.06897468593938 0.319924483458358 Wnt signaling pathway: CAMK2A hsa04066__11 0.285921589405423 DOWN -1.06773241436944 0.32036175700226 HIF-1 signaling pathway: SLC2A1 hsa05211__43 0.288735385314452 UP 1.0615210565197 0.323321685939127 Renal cell carcinoma: RAP1A hsa05223__14 0.296138348822161 UP 1.04537152611039 0.33141391151688 Non-small cell lung cancer: CCND1 hsa04066__37 0.297288441891305 UP 1.0428869829705 0.332502965662953 HIF-1 signaling pathway: PDHA1 hsa05145__29 0.304836698848436 DOWN -1.02673745256119 0.340742508706848 Toxoplasmosis: C06314 hsa04210__73 0.307184689066808 UP 1.0217683662814 0.343162919593658 Apoptosis: TRAF1 hsa04360__111 0.307773537480852 UP 1.02052609471145 0.343616444994962 Axon guidance: RHOA*** hsa05200__218 0.308953473973524 DOWN -1.01804155157156 0.34472896531844 Pathways in cancer: CSF3R* hsa05132__68 0.314897957320041 UP 1.00561883587209 0.351153271100509 Salmonella infection: NOS2 hsa04917__44 0.316695864570699 UP 1.00189202116225 0.352948712650263 Prolactin signaling pathway: PRLR** hsa04931__47 0.323345696571362 DOWN -0.988227033892829 0.360146155220859 Insulin resistance: AKT2* hsa03320__61 0.3239547074186 DOWN -0.986984762322882 0.360610719928643 PPAR signaling pathway: APOA1 hsa04917__56 0.327010961548696 UP 0.980773404473147 0.363582009911242 Prolactin signaling pathway: LHCGR hsa04917__38 0.327010961548696 UP 0.980773404473147 0.363582009911242 Prolactin signaling pathway: IRF1 hsa04066__5 0.330085879082167 DOWN -0.974562046623412 0.366783776933998 HIF-1 signaling pathway: VEGFA hsa05223__37 0.331321070691875 UP 0.972077503483518 0.367938706755339 Non-small cell lung cancer: CCND1* hsa04910__20 0.331939785857204 UP 0.970835231913571 0.368408067114995 Insulin signaling pathway: PKLR hsa04668__138 0.332559247190463 UP 0.969592960343624 0.368877700986352 TNF signaling pathway: NFKB1* hsa04152__53 0.334422107613414 DOWN -0.965866145633783 0.370725156463483 AMPK signaling pathway: G6PC hsa04380__38 0.342572053358434 UP 0.949716615224472 0.379535901096991 Osteoclast differentiation: FOS hsa04064__114 0.348926910396214 DOWN -0.937293899525002 0.386348653290799 NF-kappa B signaling pathway: BCL2A1* hsa05162__27 70 0.349566488795547 UP 0.936051627955055 0.386828876588241 Measles: STAT1 GNB2L1 hsa05205__236 0.350206810854435 UP 0.934809356385108 0.387309357030891 Proteoglycans in cancer: ITGAV hsa05205__189 0.354709876956652 UP 0.92611345539548 0.392058740471499 Proteoglycans in cancer: IL12B hsa04064__96 0.36251404486414 UP 0.911206196556116 0.400213801586204 NF-kappa B signaling pathway: BCL2A1 hsa04917__57 0.36251404486414 DOWN -0.911206196556116 0.400213801586204 Prolactin signaling pathway: ESR1 hsa04668__153 0.363169210680178 DOWN -0.909963924986169 0.400701671678247 TNF signaling pathway: MAPK14* hsa04668__40 0.364481763715739 UP 0.907479381846275 0.401913869731146 TNF signaling pathway: JUN hsa04722__34 0.377098464647218 UP 0.883876222017282 0.415582413532037 Neurotrophin signaling pathway: GSK3B hsa04933__22 0.382490364037265 UP 0.873938049457706 0.421277487705757 AGE-RAGE signaling pathway in diabetic complications: EDN1 hsa05205__81 0.383167658794561 DOWN -0.872695777887759 0.42177623367017 Proteoglycans in cancer: CTTN hsa04740__37 0.386565139716118 UP 0.866484420038024 0.425266918926573 Olfactory transduction: CNGB1* hsa04261__15 16 0.387246835529828 DOWN -0.865242148468077 0.42576758569956 Adrenergic signaling in cardiomyocytes: ACTC1 TPM1 hsa04540__12 0.387929188870992 UP 0.86399987689813 0.426268389408534 Gap junction: C00025 hsa04668__128 0.38929631749287 UP 0.861515333758236 0.427520619853363 TNF signaling pathway: CHUK* hsa04064__36 0.389980942089433 UP 0.860273062188289 0.428022307351662 NF-kappa B signaling pathway: PLCG1 hsa04390__58 0.397560030431384 UP 0.846608074918872 0.436085987846217 Hippo signaling pathway: SMAD7 hsa04340__40 0.400337933026023 UP 0.841638988639084 0.438620977350377 Hedgehog signaling pathway: SUFU hsa05014__49 0.400337933026023 DOWN -0.841638988639084 0.438620977350377 Amyotrophic lateral sclerosis (ALS): C00001 hsa04610__7 0.402428995480196 DOWN -0.837912173929243 0.440655059736182 Complement and coagulation cascades: C00290 hsa04910__24 0.403127468993966 UP 0.836669902359296 0.44116279221879 Insulin signaling pathway: ACACA hsa05134__72 0.40663071717162 UP 0.830458544509561 0.444737553879786 Legionellosis: IL12A hsa04350__50 0.407333540611265 UP 0.829216272939614 0.445247075514 TGF-beta signaling pathway: AMHR2 hsa05221__6 0.411565669361203 UP 0.821762643519933 0.449611565540524 Acute myeloid leukemia: CEBPA hsa04960__13 0.414401527742327 DOWN -0.816793557240145 0.452446525640809 Aldosterone-regulated sodium reabsorption: FXYD4 hsa05200__217 0.41724891064923 UP 0.811824470960357 0.455290768356506 Pathways in cancer: E2F1* hsa04350__34 0.42154154134357 DOWN -0.804370841540675 0.45944115787968 TGF-beta signaling pathway: ROCK1 hsa05145__8 0.42154154134357 DOWN -0.804370841540675 0.45944115787968 Toxoplasmosis: NFKB1 hsa04723__7 0.422259489792642 UP 0.803128569970728 0.459956858736449 Retrograde endocannabinoid signaling: ITPR1 hsa05200__200 0.424417630169839 DOWN -0.799401755260887 0.462039818707489 Pathways in cancer: FIGF hsa04742__48 0.429478293746577 UP 0.790705854271258 0.467278352026531 Taste transduction: GABBR1 hsa04022__59 0.432385775165654 DOWN -0.78573676799147 0.470169485842745 cGMP-PKG signaling pathway: NPPB hsa05140__62 0.438234805407171 UP 0.775798595431894 0.476254019294433 Leishmaniasis: C00584 hsa05211__40 0.439704139796774 DOWN -0.773314052292 0.477574611952681 Renal cell carcinoma: PAK4 hsa05161__194 0.441913434332663 UP 0.769587237582159 0.479696905321244 Hepatitis B: TNF* hsa05014__54 0.443389820610098 UP 0.767102694442265 0.481021635638784 Amyotrophic lateral sclerosis (ALS): PPP3CA hsa05321__46 0.444129069325518 UP 0.765860422872318 0.481545597958828 Inflammatory bowel disease (IBD): IFNG* hsa05321__74 0.456052340212867 UP 0.745984077753166 0.49418820487888 Inflammatory bowel disease (IBD): IL5 hsa04623__8 0.459061045968167 UP 0.741014991473378 0.49716178984103 Cytosolic DNA-sensing pathway: TBK1 hsa05140__16 0.463594887082327 UP 0.733561362053696 0.501782714762496 Leishmaniasis: STAT1 hsa04024__43 0.470442179950059 DOWN -0.722380917924173 0.508900895869984 cAMP signaling pathway: MAPK8 hsa05160__54 0.474270229958699 UP 0.716169560074439 0.512746698557189 Hepatitis C: IRF1 hsa04972__21 0.476575249410421 DOWN -0.712442745364598 0.514942434526844 Pancreatic secretion: KCNQ1 hsa04933__58 0.480430547152997 DOWN -0.706231387514863 0.518809769023265 AGE-RAGE signaling pathway in diabetic complications: CCL2 hsa04380__69 0.499170343553513 DOWN -0.676416869836135 0.538736976184406 Osteoclast differentiation: NFKB2 hsa04610__17 0.501539821948996 DOWN -0.672690055126294 0.540983539289417 Complement and coagulation cascades: PLG hsa04660__14 0.502330969464631 DOWN -0.671447783556347 0.541526042239841 T cell receptor signaling pathway: NFKB1 hsa05169__64 0.504708366776206 DOWN -0.667720968846506 0.543776961681474 Epstein-Barr virus infection: NFKB2 hsa05205__17 0.508683837481781 UP 0.661509610996771 0.547746092050582 Proteoglycans in cancer: AKT3 hsa04910__14 0.511076974831134 UP 0.65778279628693 0.550007809683678 Insulin signaling pathway: C00369 hsa04115__40 0.511875992272416 UP 0.656540524716983 0.550552369479033 p53 signaling pathway: PIDD1 hsa04360__145 0.515078568269474 DOWN -0.651571438437195 0.553679994152369 Axon guidance: ABLIM3 hsa04064__2 0.518291520159903 DOWN -0.646602352157407 0.55681518946853 NF-kappa B signaling pathway: BCL2L1 hsa04114__56 0.530431707549104 DOWN -0.627968278608202 0.569532101991295 Oocyte meiosis: REC8 hsa04622__6 0.534510285927409 UP 0.621756920758467 0.573256179941553 RIG-I-like receptor signaling pathway: NFKB1 hsa05142__49 0.534510285927409 DOWN -0.621756920758467 0.573256179941553 Chagas disease (American trypanosomiasis): ADCY1 hsa05200__210 0.536146137160171 DOWN -0.619272377618573 0.57468259653392 Pathways in cancer: MMP1 hsa04976__38 0.536965006795341 DOWN -0.618030106048627 0.575232182308122 Bile secretion: ABCC2 hsa04010__78 0.537784504735854 DOWN -0.616787834478679 0.575781814472177 MAPK signaling pathway: MAP3K4 hsa05169__60 0.549323004558693 DOWN -0.599396032499422 0.587800640982793 Epstein-Barr virus infection: NFKB1 hsa04022__58 0.55098127417429 DOWN -0.596911489359528 0.589239507213142 cGMP-PKG signaling pathway: MYH7 hsa05168__122 0.551811331355384 DOWN -0.595669217789581 0.589791519690993 Herpes simplex infection: CASP3 hsa05200__192 0.559309367633144 UP 0.584488773660058 0.597465777022557 Pathways in cancer: PTGS2 hsa05213__11 0.566856509931878 UP 0.573308329530535 0.605183739864772 Endometrial cancer: FOXO3 hsa04620__34 0.582947781645111 UP 0.549705169701542 0.622009586434505 Toll-like receptor signaling pathway: IL1B hsa04360__11 0.583800560041926 UP 0.548462898131595 0.622212848734418 Axon guidance: NFATC2 hsa05168__123 0.583800560041926 DOWN -0.548462898131595 0.622212848734418 Herpes simplex infection: CYCS hsa05161__188 0.584653919010102 DOWN -0.547220626561648 0.622769112142847 Hepatitis B: IFNB1 hsa04530__8 0.59150158010822 UP 0.537282454002072 0.629706214744105 Tight junction: LLGL2 hsa04072__57 0.594939172962098 UP 0.532313367722284 0.633007194788099 Phospholipase D signaling pathway: C06124 hsa05205__352 0.596661244159349 UP 0.52982882458239 0.634480179838945 Proteoglycans in cancer: ITGA5* hsa05166__62 63 0.607910638952379 DOWN -0.513679294173079 0.646076974316471 HTLV-I infection: ANAPC10 CDC20 hsa04621__43 0.608779870586996 DOWN -0.512437022603133 0.646635034953627 NOD-like receptor signaling pathway: MAPK1 hsa04520__10 0.609649655067202 UP 0.511194751033186 0.647193051904674 Adherens junction: NLK hsa04922__36 0.614006835367328 UP 0.504983393183451 0.651450504604861 Glucagon signaling pathway: GYS1 hsa04010__57 0.618377687090251 DOWN -0.498772035333716 0.655717649008229 MAPK signaling pathway: NLK hsa04151__25 0.635109363085726 DOWN -0.475168875504723 0.6730798044208 PI3K-Akt signaling pathway: CDKN1B hsa05200__76 0.635995261492049 DOWN -0.473926603934776 0.673638723981714 Pathways in cancer: RAC1 hsa04961__17 0.639544054865686 DOWN -0.468957517654988 0.677015931883168 Endocrine and other factor-regulated calcium reabsorption: CALB1 hsa04068__46 0.643991665926072 UP 0.462746159805253 0.680956860031002 FoxO signaling pathway: PLK4 hsa04931__46 0.643991665926072 UP 0.462746159805253 0.680956860031002 Insulin resistance: PIK3R5* hsa04110__46 0.649345663242964 DOWN -0.455292530385571 0.686232002943493 Cell cycle: RB1 hsa04340__14 0.663711198599245 DOWN -0.435416185266419 0.701019304197853 Hedgehog signaling pathway: PTCH1 hsa05169__104 0.670035600644682 DOWN -0.42672028427679 0.707301625624358 Epstein-Barr virus infection: IRF3 hsa03320__46 0.677292213375077 UP 0.416782111717214 0.71456039805265 PPAR signaling pathway: APOA2 hsa04668__111 0.680021228636266 UP 0.413055297007373 0.717036974527241 TNF signaling pathway: BAG4 hsa04010__87 0.680931834811103 UP 0.411813025437426 0.71759445743694 MAPK signaling pathway: STK3 hsa04210__57 0.683666440261525 DOWN -0.408086210727586 0.720072444647649 Apoptosis: BAK1 hsa05032__4 0.691895063983449 DOWN -0.396905766598063 0.728330994523754 Morphine addiction: ADCY1 hsa04623__9 0.693728639680109 DOWN -0.394421223458169 0.729852247457405 Cytosolic DNA-sensing pathway: IKBKE hsa04931__137 0.698320410513154 DOWN -0.388209865608434 0.734271992923456 Insulin resistance: MLXIP* hsa04064__94 0.701080795191356 UP 0.384483050898593 0.736762200315748 NF-kappa B signaling pathway: BCL2L1* hsa04340__17 0.704767449643746 UP 0.379513964618805 0.740222491828172 Hedgehog signaling pathway: SMO hsa04510__20 4 5 0.716796652068805 DOWN -0.363364434209494 0.752436262143735 Focal adhesion: VASP ITGB1 ITGA11 hsa05110__46 0.732633360232052 UP 0.342245817520395 0.768630979271929 Vibrio cholerae infection: PLCG1 hsa04550__53 64 0.73825048652142 DOWN -0.334792188100713 0.774091888489815 Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4 hsa04932__58 0.742003037004473 UP 0.329823101820925 0.777592697451983 Non-alcoholic fatty liver disease (NAFLD): BAX hsa04024__101 0.747643356008147 DOWN -0.322369472401243 0.783066814904854 cAMP signaling pathway: HCN4 hsa04210__83 0.755184799098075 UP 0.312431299841667 0.790524923401272 Apoptosis: TP53* hsa04015__95 0.758018910733241 UP 0.308704485131827 0.792608532703261 Rap1 signaling pathway: THBS1 hsa05145__4 5 0.758018910733241 UP 0.308704485131827 0.792608532703261 Toxoplasmosis: MAP3K7 TAB1 hsa05164__36 0.760856278274151 UP 0.304977670421986 0.795132895927213 Influenza A: IL33 hsa04152__103 0.768438237470623 DOWN -0.29503949786241 0.802610032355365 AMPK signaling pathway: ULK1 hsa05140__26 0.772237591290887 UP 0.290070411582622 0.806130241130876 Leishmaniasis: C00533 hsa05150__40 0.792271905832995 UP 0.263982708613735 0.82658462579689 Staphylococcus aureus infection: FCGR1A hsa05134__68 0.799941046914209 DOWN -0.254044536054159 0.834122767564816 Legionellosis: TNF hsa05168__91 92 0.804744125993595 UP 0.247833178204424 0.838665675397651 Herpes simplex infection: STAT1 IRF9 hsa04261__15 17 0.807629527413827 DOWN -0.244106363494583 0.841206143021387 Adrenergic signaling in cardiomyocytes: ACTC1 MYH6 hsa05200__204 0.809554585950356 UP 0.241621820354689 0.842744081440842 Pathways in cancer: TGFB1* hsa05145__35 0.813408150890255 DOWN -0.236652734074901 0.846286774929562 Toxoplasmosis: CASP3 hsa04933__24 0.816301297300553 DOWN -0.23292591936506 0.848826860889728 AGE-RAGE signaling pathway in diabetic complications: THBD hsa05010__59 0.818231450407284 UP 0.230441376225166 0.84942370493514 Alzheimer's disease: LRP1 hsa04621__6 0.818231456057799 UP 0.230441376225166 0.84942370493514 NOD-like receptor signaling pathway: NFKB1 hsa05168__9 0.818231456057799 UP 0.230441376225166 0.84942370493514 Herpes simplex infection: NFKB1 hsa05032__31 0.82499561915991 UP 0.221745475235537 0.855028553999708 Morphine addiction: GABRR3 hsa05032__33 0.82499561915991 UP 0.221745475235537 0.855028553999708 Morphine addiction: GABRR3* hsa05032__55 0.82499561915991 UP 0.221745475235537 0.855028553999708 Morphine addiction: GABRR3** hsa04064__25 0.832742004557399 DOWN -0.211807302675961 0.862581161280789 NF-kappa B signaling pathway: NFKB2 hsa04550__17 0.836621346184673 UP 0.206838216396173 0.866122043791185 Signaling pathways regulating pluripotency of stem cells: AKT3 hsa04014__27 0.840504665043137 DOWN -0.201869130116386 0.869184516024245 Ras signaling pathway: ABL1 hsa05160__77 0.840504665043137 UP 0.201869130116386 0.869184516024245 Hepatitis C: NFKB1* hsa05219__19 0.84828286654757 DOWN -0.19193095755681 0.876745602993885 Bladder cancer: TP53 hsa04750__7 0.85705095057015 UP 0.180750513427287 0.884834470396326 Inflammatory mediator regulation of TRP channels: TRPV1 hsa04750__58 0.85705095057015 UP 0.180750513427287 0.884834470396326 Inflammatory mediator regulation of TRP channels: TRPV1** hsa04723__10 0.85997769131022 DOWN -0.177023698717446 0.886881493947258 Retrograde endocannabinoid signaling: CACNA1A hsa04723__21 0.85997769131022 DOWN -0.177023698717446 0.886881493947258 Retrograde endocannabinoid signaling: CACNA1A* hsa05205__120 0.862906307529867 DOWN -0.173296884007605 0.88941357753627 Proteoglycans in cancer: PLAU hsa04062__59 0.865836809007791 UP 0.169570069297764 0.891456089931857 Chemokine signaling pathway: FOXO3 hsa04213__53 0.865836809007791 UP 0.169570069297764 0.891456089931857 Longevity regulating pathway - multiple species: SOD1 hsa04670__45 0.88051620963411 DOWN -0.150935995748559 0.906073361392383 Leukocyte transendothelial migration: PXN hsa04971__49 0.883457190248753 UP 0.147209181038718 0.908602113014453 Gastric acid secretion: KCNJ1 hsa04210__61 0.890325659067775 UP 0.138513280049089 0.915165160496909 Apoptosis: APAF1 hsa04360__125 0.891307553513329 UP 0.137271008479142 0.915673533653114 Axon guidance: ENAH* hsa05205__34 0.899168585118479 DOWN -0.127332835919566 0.923244683845695 Proteoglycans in cancer: SLC9A1 hsa04390__80 0.91196354769348 DOWN -0.111183305510255 0.935870838949235 Hippo signaling pathway: BIRC2 hsa05321__122 0.913934115580394 DOWN -0.108698762370361 0.937381115270503 Inflammatory bowel disease (IBD): IL4** hsa05145__11 0.916890955929608 DOWN -0.10497194766052 0.939900767153155 Toxoplasmosis: MAPK14 hsa05161__92 0.921821558940793 DOWN -0.0987605898107855 0.944439863276854 Hepatitis B: NFKBIA hsa05169__30 0.924781375931774 DOWN -0.0950337751009446 0.946955970232046 Epstein-Barr virus infection: FGR hsa04920__37 0.925768215078749 UP 0.0937915035309976 0.947450150399221 Adipocytokine signaling pathway: IRS1 hsa04510__23 4 5 0.930704093997993 UP 0.0875801456812626 0.951983120643565 Focal adhesion: TLN1 ITGB1 ITGA11 hsa05140__43 0.940583662880525 DOWN -0.0751574299817928 0.961565126524758 Leishmaniasis: MAPK14 hsa05145__10 0.955419701777345 UP 0.0565233564325879 0.976200989472339 Toxoplasmosis: MAPK8 hsa04530__4 53 0.961358734545657 UP 0.049069727012906 0.981202097887719 Tight junction: OCLN OCLN hsa04530__4 45 0.961358734545657 UP 0.049069727012906 0.981202097887719 Tight junction: OCLN TJP2 hsa05205__150 0.968290293108816 UP 0.0403738260232771 0.987142808567492 Proteoglycans in cancer: PRKCA hsa05205__400 0.968290294111566 UP 0.0403738260232771 0.987142808567492 Proteoglycans in cancer: ITGA2* hsa05110__12 0.969280724750943 UP 0.0391315544533301 0.987142808567492 Vibrio cholerae infection: C00080 hsa05120__35 0.969280724750943 UP 0.0391315544533301 0.987142808567492 Epithelial cell signaling in Helicobacter pylori infection: C00080 hsa05205__324 0.970271202774045 UP 0.0378892828833831 0.987616245943895 Proteoglycans in cancer: KDR* hsa05142__29 0.974233558173569 DOWN -0.0329201966035952 0.99111253698329 Chagas disease (American trypanosomiasis): NOS2 hsa04310__14 0.976214980480856 DOWN -0.0304356534637012 0.99151780990461 Wnt signaling pathway: PRKCA hsa04621__21 31 41 0.976214980480856 DOWN -0.0304356534637012 0.99151780990461 NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1 hsa05142__53 0.976214980480856 UP 0.0304356534637012 0.99151780990461 Chagas disease (American trypanosomiasis): AKT3 hsa04012__43 0.980178253213665 UP 0.0254665671839133 0.99500536887546 ErbB signaling pathway: PTK2 hsa04750__39 0.982160079192447 DOWN -0.0229820240440193 0.996478827647196 Inflammatory mediator regulation of TRP channels: C01245* hsa05212__31 0.984142015277727 UP 0.0204974809041253 0.997950807720911 Pancreatic cancer: RAC1* hsa04015__27 0.986124049240585 UP 0.0180129377642313 0.999421299095502 Rap1 signaling pathway: RALA hsa04510__26 4 5 0.989097256950166 UP 0.0142861230543904 1 Focal adhesion: ACTN4 ITGB1 ITGA11 hsa04510__6 4 5 0.990088361874523 UP 0.0130438514844434 1 Focal adhesion: FLNA ITGB1 ITGA11 hsa05152__88 89 0.993061762301627 DOWN -0.00931703677460241 1 Tuberculosis: ITGAX ITGB2 hsa04725__25 0.997026438965418 DOWN -0.00434795049481446 1 Cholinergic synapse: CACNA1A hsa04152__33 1 0 0 1 AMPK signaling pathway: CPT1C hsa04152__41 1 0 0 1 AMPK signaling pathway: FBP1 hsa04211__2 1 0 0 1 Longevity regulating pathway - mammal: RPS6KB1 hsa04911__41 1 0 0 1 Insulin secretion: ABCC8 hsa04911__35 1 0 0 1 Insulin secretion: TRPM4 hsa04922__67 1 0 0 1 Glucagon signaling pathway: FBP1 hsa04922__60 1 0 0 1 Glucagon signaling pathway: CPT1C* hsa04924__34 1 0 0 1 Renin secretion: REN hsa04924__47 1 0 0 1 Renin secretion: KCNMA1 hsa04931__151 1 0 0 1 Insulin resistance: CPT1A hsa04931__29 1 0 0 1 Insulin resistance: CPT1B hsa04960__15 1 0 0 1 Aldosterone-regulated sodium reabsorption: C00762 hsa05030__13 1 0 0 1 Cocaine addiction: SLC6A3 hsa05031__15 1 0 0 1 Amphetamine addiction: MAOA hsa05031__77 1 0 0 1 Amphetamine addiction: MAOA* hsa05034__7 1 0 0 1 Alcoholism: GRIN3A hsa05034__75 1 0 0 1 Alcoholism: SLC29A1 hsa05140__37 1 0 0 1 Leishmaniasis: ELK1 hsa05140__55 1 0 0 1 Leishmaniasis: JUN hsa05140__41 57 1 0 0 1 Leishmaniasis: NOS2 CYBA hsa05211__12 1 0 0 1 Renal cell carcinoma: EGLN2