p.value UP.DOWN statistic FDRp.value path.name hsa05166__33 3.34614060303138e-65 UP 12.6743167545424 6.28739819309595e-62 HTLV-I infection: HLA-A hsa04211__43 59 60 61 4.92052112030031e-43 UP 13.7527448088931 2.35940249679413e-40 Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101 hsa04530__11 24 23 4.92858889721347e-43 DOWN -13.7527448088931 2.35940249679413e-40 Tight junction: TJP1 YBX3 CDK4 hsa04750__8 5.02267694900294e-43 DOWN -13.7512583470676 2.35940249679413e-40 Inflammatory mediator regulation of TRP channels: ASIC2 hsa05120__20 1.3732599651343e-42 UP 13.6784217176215 5.16071094897469e-40 Epithelial cell signaling in Helicobacter pylori infection: CXCL8 hsa04962__10 2.04487908889007e-42 DOWN -13.6494357120256 6.40387968004075e-40 Vasopressin-regulated water reabsorption: AQP2 hsa05212__34 1.2203551256987e-41 UP 13.5186270713876 3.27578183026836e-39 Pancreatic cancer: E2F1 hsa05131__38 1.66866990274976e-41 UP 13.4955869130934 3.64724810963511e-39 Shigellosis: CXCL8 hsa04662__32 51 1.7727362015143e-41 DOWN -13.4911275276171 3.64724810963511e-39 B cell receptor signaling pathway: BLNK GRB2 hsa04010__117 1.94105806792715e-41 UP 13.4844384494027 3.64724810963511e-39 MAPK signaling pathway: JUND hsa05214__35 2.59922935753778e-41 UP 13.4628847529339 4.43995632983045e-39 Glioma: E2F1 hsa04550__101 3.02242274361473e-41 DOWN -13.4517362892432 4.73261027937673e-39 Signaling pathways regulating pluripotency of stem cells: ESRRB hsa04960__13 4.00403646781194e-41 DOWN -13.4309258236871 5.48976819534769e-39 Aldosterone-regulated sodium reabsorption: FXYD4 hsa04530__11 33 4.16803854560979e-41 DOWN -13.4279529000363 5.48976819534769e-39 Tight junction: TJP1 CGN hsa04960__3 4.38246529697793e-41 DOWN -13.4242367454727 5.48976819534769e-39 Aldosterone-regulated sodium reabsorption: SCNN1A hsa04010__134 5.24930039334029e-41 UP 13.4108585890438 6.164647149429e-39 MAPK signaling pathway: ATF4* hsa04917__34 6.54331472268495e-41 DOWN -13.394507508964 7.23228727289708e-39 Prolactin signaling pathway: ELF5 hsa04666__23 7.91319283429384e-41 UP 13.3803861216224 8.26049407535451e-39 Fc gamma R-mediated phagocytosis: RPS6KB1 hsa04960__27 1.10034832195612e-40 DOWN -13.3558595015028 1.08818657734503e-38 Aldosterone-regulated sodium reabsorption: KCNJ1 hsa04933__30 1.55991943880609e-40 UP 13.3298464195578 1.46554431275832e-38 AGE-RAGE signaling pathway in diabetic complications: CXCL8 hsa04742__47 2.20994709309522e-40 DOWN -13.3038333376127 1.97737647044092e-38 Taste transduction: GABRA1 hsa04662__27 2.34577413844198e-40 DOWN -13.2993739521364 2.00350436642386e-38 B cell receptor signaling pathway: NFATC1 hsa04810__82 83 3.52426981979501e-40 UP 13.2689014847151 2.87917521364993e-38 Regulation of actin cytoskeleton: ACTB ARPC5 hsa04919__28 5.50348222871445e-40 DOWN -13.2354560936429 4.30479609603143e-38 Thyroid hormone signaling pathway: RCAN1 hsa04530__22 33 5.89800029569538e-40 DOWN -13.2302534772539 4.30479609603143e-38 Tight junction: MYL12B CGN hsa05120__18 5.95660981888329e-40 UP 13.2295102463411 4.30479609603143e-38 Epithelial cell signaling in Helicobacter pylori infection: CCL5 hsa04530__6 11 45 7.18698473083762e-40 DOWN -13.2153888589995 5.00160900342366e-38 Tight junction: CLDN24 TJP1 TJP2 hsa04916__7 8.0910721806632e-40 DOWN -13.2064700880469 5.4296873669522e-38 Melanogenesis: TYRP1 hsa04010__118 8.50036028468183e-40 UP 13.2027539334834 5.50764723273005e-38 MAPK signaling pathway: JUN hsa05205__337 8.93022964774859e-40 DOWN -13.1990377789198 5.59330050270653e-38 Proteoglycans in cancer: CTNNB1** hsa04933__57 1.16534938694059e-39 UP 13.1789705442765 7.0635209614883e-38 AGE-RAGE signaling pathway in diabetic complications: FIGF hsa04390__90 1.22417434859195e-39 UP 13.1752543897129 7.18819875313837e-38 Hippo signaling pathway: BBC3 hsa04210__74 1.3115209355171e-39 UP 13.1700517733239 7.46772072071705e-38 Apoptosis: BAX* hsa05231__39 1.53513729745253e-39 UP 13.1581600787204 8.48389112327442e-38 Choline metabolism in cancer: EIF4EBP1 hsa05321__83 1.64452608812353e-39 UP 13.1529574623314 8.82875577024034e-38 Inflammatory bowel disease (IBD): IL2 hsa04919__21 53 1.85037455174197e-39 DOWN -13.1440386913788 9.65792717423103e-38 Thyroid hormone signaling pathway: THRA C02465 hsa04610__58 2.25189485017287e-39 UP 13.1291740731245 1.14359741174995e-37 Complement and coagulation cascades: F2RL2 hsa03320__28 2.31917300204713e-39 DOWN -13.1269443803864 1.14677001864383e-37 PPAR signaling pathway: ACSL1 hsa04919__29 2.45978293123792e-39 DOWN -13.1224849949101 1.18511080199899e-37 Thyroid hormone signaling pathway: HIF1A hsa05223__28 3.23653422995461e-39 UP 13.101674529354 1.52036195452118e-37 Non-small cell lung cancer: RB1 hsa05200__168 4.1336712459094e-39 UP 13.0830937565361 1.87192837595822e-37 Pathways in cancer: E2F1 hsa04360__122 4.25673488337607e-39 DOWN -13.080864063798 1.87192837595822e-37 Axon guidance: CFL1** hsa04012__23 4.34079412598442e-39 DOWN -13.0793776019725 1.87192837595822e-37 ErbB signaling pathway: RPS6KB1 hsa04210__72 4.38344058233963e-39 UP 13.0786343710598 1.87192837595822e-37 Apoptosis: BCL2A1 hsa04933__43 4.9288742882473e-39 UP 13.0697156001072 2.05807884169259e-37 AGE-RAGE signaling pathway in diabetic complications: CASP3 hsa04530__8 5.12528060087061e-39 DOWN -13.0667426764564 2.08944089754788e-37 Tight junction: LLGL2 hsa04650__35 5.22638223441993e-39 UP 13.0652562146309 2.08944089754788e-37 Natural killer cell mediated cytotoxicity: BID hsa04064__36 5.54173824549933e-39 UP 13.0607968291547 2.16446214061515e-37 NF-kappa B signaling pathway: PLCG1 hsa05219__12 5.64441963225876e-39 DOWN -13.0593103673292 2.16446214061515e-37 Bladder cancer: ERBB2 hsa04210__4 6.73596963840431e-39 DOWN -13.0459322109003 2.53137739011234e-37 Apoptosis: DFFA hsa04919__26 7.14180106183335e-39 DOWN -13.041472825424 2.63126356768331e-37 Thyroid hormone signaling pathway: THRB hsa04620__23 8.67836317912527e-39 UP 13.0266082071697 3.135893156457e-37 Toll-like receptor signaling pathway: CD40 hsa04110__48 9.02302967411017e-39 UP 13.0236352835189 3.19891938823642e-37 Cell cycle: RB1* hsa04010__67 9.20043235986506e-39 UP 13.0221488216934 3.20140970447897e-37 MAPK signaling pathway: ELK1 hsa04919__100 9.75371509013317e-39 DOWN -13.0176894362171 3.33222375533822e-37 Thyroid hormone signaling pathway: CTNNB1* hsa05205__183 1.08553654493959e-38 UP 13.0095138961773 3.64236279989553e-37 Proteoglycans in cancer: VEGFA* hsa04620__40 1.16199438295327e-38 UP 13.0043112797883 3.83050429047226e-37 Toll-like receptor signaling pathway: CCL5 hsa04210__60 1.20806407492868e-38 UP 13.0013383561374 3.91371102894998e-37 Apoptosis: BBC3 hsa05142__84 1.31846735934943e-38 UP 12.9946492779229 4.19898333596201e-37 Chagas disease (American trypanosomiasis): NFKB1* hsa04012__8 1.38407845416069e-38 DOWN -12.9909331233594 4.2634154350294e-37 ErbB signaling pathway: STAT5A hsa04650__39 1.38407845416069e-38 UP 12.9909331233594 4.2634154350294e-37 Natural killer cell mediated cytotoxicity: FAS hsa04650__116 1.42499270479989e-38 UP 12.9887034306212 4.31864724567578e-37 Natural killer cell mediated cytotoxicity: FCGR3A hsa05205__304 1.4671091550175e-38 DOWN -12.9864737378831 4.37571127345695e-37 Proteoglycans in cancer: MAPK1***** hsa05162__78 1.52519533892764e-38 UP 12.9835008142322 4.47787819038287e-37 Measles: FAS hsa05152__88 89 1.63238359806547e-38 UP 12.9782981978432 4.71884427810001e-37 Tuberculosis: ITGAX ITGB2 hsa05150__48 1.85175460933344e-38 UP 12.9686361959779 5.27188925899627e-37 Staphylococcus aureus infection: C3AR1 hsa05218__21 1.92496828310505e-38 UP 12.965663272327 5.31914029993294e-37 Melanoma: RB1 hsa05220__40 1.92496828310505e-38 UP 12.965663272327 5.31914029993294e-37 Chronic myeloid leukemia: RB1 hsa04210__58 2.02054436788101e-38 UP 12.9619471177635 5.50232299601219e-37 Apoptosis: BID* hsa04010__66 2.14148134631192e-38 UP 12.9574877322872 5.74834778531442e-37 MAPK signaling pathway: TP53 hsa05166__120 2.26961197115935e-38 UP 12.9530283468109 5.98068986187546e-37 HTLV-I infection: E2F1 hsa04115__21 2.29169595558825e-38 UP 12.9522851158981 5.98068986187546e-37 p53 signaling pathway: DDB2 hsa04151__27 2.75431743359935e-38 UP 12.9381637285565 7.08953761333312e-37 PI3K-Akt signaling pathway: FASLG hsa04370__15 3.00476792327518e-38 UP 12.9314746503421 7.62967422680279e-37 VEGF signaling pathway: PLA2G4B hsa05169__60 3.15355847434468e-38 UP 12.9277584957785 7.90071516439154e-37 Epstein-Barr virus infection: NFKB1 hsa04530__4 37 11 3.82561335769205e-38 DOWN -12.9128938775242 9.45832565671496e-37 Tight junction: OCLN TJP3 TJP1 hsa04921__59 4.46429138567525e-38 UP 12.9010021829208 1.08940305372517e-36 Oxytocin signaling pathway: CCND1 hsa04620__22 5.41353554924264e-38 UP 12.8861375646664 1.30410683295217e-36 Toll-like receptor signaling pathway: CD86 hsa04210__52 5.79113134532476e-38 DOWN -12.8809349482774 1.37740959466648e-36 Apoptosis: PARP2 hsa04210__56 5.90374614188472e-38 UP 12.879448486452 1.38664237507517e-36 Apoptosis: BAX hsa04151__2 6.95321029077066e-38 DOWN -12.8668135609358 1.61297310325408e-36 PI3K-Akt signaling pathway: EIF4E hsa04976__36 7.80372998295872e-38 UP 12.8578947899832 1.78819617536335e-36 Bile secretion: SLC10A1 hsa04620__48 8.18793010518062e-38 UP 12.8541786354197 1.85362899610053e-36 Toll-like receptor signaling pathway: CD80 hsa05133__27 8.42741537917991e-38 UP 12.8519489426815 1.8851325592237e-36 Pertussis: IRF3 hsa04960__4 9.01354695069987e-38 DOWN -12.8467463262925 1.99252408474883e-36 Aldosterone-regulated sodium reabsorption: ATP1B4 hsa04066__53 1.17924938790198e-37 DOWN -12.8259358607365 2.57652279054398e-36 HIF-1 signaling pathway: EGF* hsa04933__35 1.57195432137106e-37 UP 12.803638933355 3.39505996535199e-36 AGE-RAGE signaling pathway in diabetic complications: CCND1 hsa04620__29 1.76324851845678e-37 UP 12.7947201624024 3.74170361916e-36 Toll-like receptor signaling pathway: CXCL8 hsa04012__22 1.78019719028514e-37 UP 12.7939769314897 3.74170361916e-36 ErbB signaling pathway: EIF4EBP1 hsa04110__59 15 16 17 18 19 20 1.81458185187824e-37 UP 12.7924904696643 3.74170361916e-36 Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 hsa04612__18 1.81458185187824e-37 UP 12.7924904696643 3.74170361916e-36 Antigen processing and presentation: KIR2DS2 hsa04211__29 1.83202093114806e-37 DOWN -12.7917472387515 3.74170361916e-36 Longevity regulating pathway - mammal: EIF4E hsa04650__36 1.86740042001565e-37 UP 12.7902607769261 3.77295203140797e-36 Natural killer cell mediated cytotoxicity: CASP3 hsa04961__17 1.97766528961531e-37 DOWN -12.7858013914498 3.95322667998635e-36 Endocrine and other factor-regulated calcium reabsorption: CALB1 hsa04623__17 2.15530979254484e-37 UP 12.7791123132354 4.25907045752544e-36 Cytosolic DNA-sensing pathway: NFKB1 hsa04931__13 2.17600193678788e-37 DOWN -12.7783690823227 4.25907045752544e-36 Insulin resistance: AKT2 hsa05152__20 2.40495509004286e-37 UP 12.7701935422828 4.63435792095369e-36 Tuberculosis: FCGR1A hsa04066__37 2.41706799496254e-37 DOWN -12.7701935422828 4.63435792095369e-36 HIF-1 signaling pathway: PDHA1 hsa05219__21 2.73638716109353e-37 UP 12.7605315404175 5.1909630511373e-36 Bladder cancer: RB1 hsa05200__66 2.76262003785913e-37 UP 12.7597883095048 5.1909630511373e-36 Pathways in cancer: CCND1 hsa04621__23 2.81583802245823e-37 UP 12.7583018476793 5.23857390514754e-36 NOD-like receptor signaling pathway: CASP1 hsa04064__96 3.03909429664914e-37 UP 12.7523560003776 5.59848841510171e-36 NF-kappa B signaling pathway: BCL2A1 hsa05200__223 3.12727757485189e-37 UP 12.7501263076395 5.65014861841029e-36 Pathways in cancer: CCND1**** hsa05221__17 3.12727757485189e-37 UP 12.7501263076395 5.65014861841029e-36 Acute myeloid leukemia: CCND1 hsa04530__20 37 3.24882335639779e-37 DOWN -12.7471533839886 5.8138467492109e-36 Tight junction: ACTB TJP3 hsa04015__27 3.37506352286289e-37 UP 12.7441804603377 5.98277769760318e-36 Rap1 signaling pathway: RALA hsa04919__46 4.24167059651813e-37 DOWN -12.7263429184325 7.44869070173604e-36 Thyroid hormone signaling pathway: ATP1B4 hsa04210__64 4.36449654401e-37 UP 12.7241132256944 7.59341574647666e-36 Apoptosis: TNFRSF10D* hsa05110__13 4.62074079642206e-37 DOWN -12.7196538402181 7.96547885915325e-36 Vibrio cholerae infection: C00238 hsa05200__129 130 4.89217014168844e-37 DOWN -12.7151944547418 8.28143035696629e-36 Pathways in cancer: CTBP1 HDAC1 hsa05220__12 13 4.89217014168844e-37 DOWN -12.7151944547418 8.28143035696629e-36 Chronic myeloid leukemia: HDAC1 CTBP1 hsa04932__55 5.58839098179388e-37 UP 12.7047892219638 9.37552379892027e-36 Non-alcoholic fatty liver disease (NAFLD): CASP3 hsa04970__28 5.97165398027923e-37 DOWN -12.6995866055748 9.92985648579175e-36 Salivary secretion: AQP5 hsa05200__222 6.203784094262e-37 UP 12.6966136819239 1.0225359923788e-35 Pathways in cancer: CASP9* hsa04114__80 6.44388325290998e-37 UP 12.6936407582731 1.05287448975807e-35 Oocyte meiosis: CDC25C* hsa04210__105 6.6932159384735e-37 DOWN -12.6906678346222 1.08418558175791e-35 Apoptosis: ACTB hsa05130__26 7.0853032424802e-37 DOWN -12.6862084491459 1.13788758911285e-35 Pathogenic Escherichia coli infection: CTNNB1 hsa04530__11 62 7.22100650885248e-37 DOWN -12.6847219873205 1.14985349407914e-35 Tight junction: TJP1 SHROOM1 hsa04151__99 7.50021068782169e-37 UP 12.6817490636696 1.18427696490899e-35 PI3K-Akt signaling pathway: MYB hsa04010__131 8.0148759410167e-37 UP 12.6765464472806 1.25499599109753e-35 MAPK signaling pathway: MYC hsa04976__95 96 8.24605235902672e-37 UP 12.6743167545424 1.28052333740588e-35 Bile secretion: SLC51A SLC51B hsa04360__117 1.00607644570957e-36 UP 12.6587089053754 1.5495226569576e-35 Axon guidance: CFL1* hsa04621__29 1.28658359482249e-36 UP 12.6393849016448 1.96543949160281e-35 NOD-like receptor signaling pathway: CASP5 hsa04961__20 1.35976376424692e-36 DOWN -12.6341822852558 2.06048073630643e-35 Endocrine and other factor-regulated calcium reabsorption: CALB1* hsa04152__62 1.37456792730601e-36 UP 12.6341822852558 2.0662505083264e-35 AMPK signaling pathway: EIF4EBP1 hsa04152__78 1.42750314228015e-36 UP 12.6312093616049 2.12879238440032e-35 AMPK signaling pathway: CCNA2 hsa04932__56 1.46852964877002e-36 UP 12.6289796688668 2.17273008664477e-35 Non-alcoholic fatty liver disease (NAFLD): CASP7 hsa04064__114 1.62923998922066e-36 UP 12.6208041288269 2.39167339042627e-35 NF-kappa B signaling pathway: BCL2A1* hsa04650__110 111 1.75698738127692e-36 UP 12.6148582815252 2.55920875148785e-35 Natural killer cell mediated cytotoxicity: ITGAL ITGB2 hsa03320__41 1.77364017312729e-36 UP 12.6141150506125 2.56359221946629e-35 PPAR signaling pathway: ANGPTL4 hsa05221__35 2.14167188810203e-36 UP 12.5992504323581 3.0719095249952e-35 Acute myeloid leukemia: EIF4EBP1 hsa04919__43 2.16194580695878e-36 DOWN -12.5985072014454 3.07749709945117e-35 Thyroid hormone signaling pathway: TBC1D4 hsa05223__14 2.2662121474681e-36 UP 12.5947910468819 3.20166362788914e-35 Non-small cell lung cancer: CCND1 hsa05168__27 2.37547444023779e-36 UP 12.5910748923183 3.33098244269165e-35 Herpes simplex infection: IRF3 hsa05142__67 2.53728975239059e-36 UP 12.5858722759293 3.53153144054956e-35 Chagas disease (American trypanosomiasis): IFNGR1* hsa05161__130 2.65953406641986e-36 UP 12.5821561213657 3.67445919911979e-35 Hepatitis B: FASLG* hsa04015__11 2.73567178772199e-36 UP 12.5799264286275 3.69807718642418e-35 Rap1 signaling pathway: RAC1 hsa05160__71 2.73567178772199e-36 DOWN -12.5799264286275 3.69807718642418e-35 Hepatitis C: MAPK8 hsa05211__21 2.73567178772199e-36 UP 12.5799264286275 3.69807718642418e-35 Renal cell carcinoma: TGFB1* hsa05200__218 2.78762973792569e-36 UP 12.5784399668021 3.74139734111598e-35 Pathways in cancer: CSF3R* hsa04933__29 3.0338438443554e-36 UP 12.5717508885877 4.04297346350624e-35 AGE-RAGE signaling pathway in diabetic complications: ICAM1 hsa04072__36 3.17984582624236e-36 DOWN -12.5680347340241 4.20769739965451e-35 Phospholipase D signaling pathway: MTOR hsa05164__24 3.24018293963788e-36 UP 12.5665482721987 4.22798871081915e-35 Influenza A: IRF7 hsa05211__27 3.24018293963788e-36 UP 12.5665482721987 4.22798871081915e-35 Renal cell carcinoma: VEGFA* hsa04976__16 3.30165769029277e-36 DOWN -12.5650618103732 4.24918821921925e-35 Bile secretion: CFTR hsa05132__68 3.30165769029277e-36 UP 12.5650618103732 4.24918821921925e-35 Salmonella infection: NOS2 hsa05162__28 34 3.42810574557592e-36 UP 12.5620888867224 4.38191203805249e-35 Measles: IRF9 STAT1 hsa04014__70 3.52608949290511e-36 UP 12.5598591939842 4.47670416024912e-35 Ras signaling pathway: RIN1* hsa04010__61 3.8732443944344e-36 UP 12.5524268848571 4.8518841447615e-35 MAPK signaling pathway: ATF4 hsa04330__11 3.8732443944344e-36 UP 12.5524268848571 4.8518841447615e-35 Notch signaling pathway: PTCRA hsa04650__25 3.94664763948416e-36 UP 12.5509404230316 4.91109332092101e-35 Natural killer cell mediated cytotoxicity: SH2D1B hsa05164__23 4.25434424204218e-36 UP 12.5449945757299 5.25915317815609e-35 Influenza A: IRF3 hsa04210__107 4.58582571626877e-36 DOWN -12.5390487284282 5.63187354305164e-35 Apoptosis: MCL1 hsa05321__46 4.8512470265451e-36 UP 12.5345893429519 5.9191514044664e-35 Inflammatory bowel disease (IBD): IFNG* hsa04152__77 5.03658829922696e-36 UP 12.531616419301 6.10564478338546e-35 AMPK signaling pathway: CCND1 hsa04623__8 5.08401264193922e-36 UP 12.5308731883883 6.12362804756653e-35 Cytosolic DNA-sensing pathway: TBK1 hsa05142__7 5.13148315538317e-36 UP 12.5286434956501 6.14143748341719e-35 Chagas disease (American trypanosomiasis): C1QA hsa04910__48 5.18019663816243e-36 DOWN -12.5293867265629 6.16049967285266e-35 Insulin signaling pathway: PPARGC1A hsa04668__138 5.32787335928795e-36 UP 12.5271570338247 6.29627298245412e-35 TNF signaling pathway: NFKB1* hsa04726__10 5.47973296370355e-36 DOWN -12.5249273410866 6.43526139924935e-35 Serotonergic synapse: PRKACA hsa04933__62 5.53130261113373e-36 UP 12.5241841101739 6.45547677411197e-35 AGE-RAGE signaling pathway in diabetic complications: AGER** hsa04666__20 5.58335451413814e-36 DOWN -12.5234408792611 6.47600193337381e-35 Fc gamma R-mediated phagocytosis: PLA2G4B hsa04972__42 5.90604714109527e-36 DOWN -12.5189814937848 6.78900082308028e-35 Pancreatic secretion: CFTR hsa04064__136 5.96160263868146e-36 UP 12.5182382628721 6.78900082308028e-35 NF-kappa B signaling pathway: TNFSF13B* hsa05134__7 5.96160263868146e-36 UP 12.5182382628721 6.78900082308028e-35 Legionellosis: IL18 hsa04961__5 6.24726647054345e-36 DOWN -12.5145221083085 7.0714540350308e-35 Endocrine and other factor-regulated calcium reabsorption: TRPV5 hsa05150__13 7.46239597371212e-36 UP 12.5004007209669 8.3963125955719e-35 Staphylococcus aureus infection: C5AR1 hsa04071__65 8.74718904232341e-36 UP 12.4877657954508 9.78331441102719e-35 Sphingolipid signaling pathway: BAX* hsa04933__78 9.42563585852902e-36 UP 12.481819948149 1.04797454308734e-34 AGE-RAGE signaling pathway in diabetic complications: TGFB1 hsa04621__33 35 1.01563473162212e-35 UP 12.4758741008473 1.12257509453998e-34 NOD-like receptor signaling pathway: NLRC4 PYCARD hsa04932__7 1.20127447513026e-35 UP 12.4624959444184 1.31999692325717e-34 Non-alcoholic fatty liver disease (NAFLD): SREBF1 hsa04922__36 1.48828412701506e-35 UP 12.445401633426 1.62586388061703e-34 Glucagon signaling pathway: GYS1 hsa04062__38 1.67965436669941e-35 UP 12.4357396315607 1.81383365231505e-34 Chemokine signaling pathway: NCF1 hsa04961__26 1.67965436669941e-35 DOWN -12.4357396315607 1.81383365231505e-34 Endocrine and other factor-regulated calcium reabsorption: TRPV5* hsa04014__37 1.69534986906507e-35 UP 12.434996400648 1.82032137369901e-34 Ras signaling pathway: FASLG hsa04115__38 1.89545599406286e-35 UP 12.4260776296954 2.0236146663887e-34 p53 signaling pathway: GTSE1 hsa05160__56 2.08001335009762e-35 DOWN -12.4186453205682 2.2081045677025e-34 Hepatitis C: MAPK1 hsa04068__48 2.19920709960068e-35 UP 12.4141859350919 2.32152255064588e-34 FoxO signaling pathway: FASLG hsa05166__65 2.21972221687827e-35 UP 12.4134427041792 2.33008829358339e-34 HTLV-I infection: PTTG2 hsa05142__64 2.24042747783099e-35 UP 12.4126994732665 2.33875735046913e-34 Chagas disease (American trypanosomiasis): CASP8 hsa04066__30 2.45833120777436e-35 UP 12.4052671641393 2.55204659635803e-34 HIF-1 signaling pathway: PDK1 hsa04261__73 2.48124719771169e-35 DOWN -12.4045239332266 2.5616832332419e-34 Adrenergic signaling in cardiomyocytes: KCNE1 hsa04919__44 2.5043754304209e-35 DOWN -12.4037807023139 2.57143247746495e-34 Thyroid hormone signaling pathway: PFKFB2 hsa05152__112 2.98684546828266e-35 UP 12.3896593149723 3.03366628913682e-34 Tuberculosis: IFNGR1 hsa05211__42 2.98684546828266e-35 UP 12.3896593149723 3.03366628913682e-34 Renal cell carcinoma: SLC2A1* hsa04066__61 3.07104328200921e-35 UP 12.3874296222341 3.10241415424479e-34 HIF-1 signaling pathway: HMOX1 hsa05216__12 3.76492266203872e-35 DOWN -12.3710785421544 3.78304261067954e-34 Thyroid cancer: CDH1 hsa04064__53 3.97983914053831e-35 UP 12.3666191566781 3.97772220482525e-34 NF-kappa B signaling pathway: CXCL8 hsa04922__70 5.25144836340648e-35 DOWN -12.3443222292966 5.22088437822263e-34 Glucagon signaling pathway: PFKFB1 hsa04530__4 45 5.49955020147124e-35 DOWN -12.340606074733 5.43202326413633e-34 Tight junction: OCLN TJP2 hsa05169__104 5.55055064776037e-35 UP 12.3398628438203 5.43202326413633e-34 Epstein-Barr virus infection: IRF3 hsa05219__10 5.55055064776037e-35 DOWN -12.3398628438203 5.43202326413633e-34 Bladder cancer: EGFR hsa05152__24 25 5.75921553261855e-35 UP 12.3368899201695 5.60702900818148e-34 Tuberculosis: ITGB2 ITGAM hsa04530__4 53 6.55323119787921e-35 DOWN -12.3264846873914 6.31462636964874e-34 Tight junction: OCLN OCLN hsa04923__52 53 6.55323119787921e-35 DOWN -12.3264846873914 6.31462636964874e-34 Regulation of lipolysis in adipocytes: PNPLA2 ABHD5* hsa04115__17 6.99006272595348e-35 UP 12.3212820710024 6.70118768472785e-34 p53 signaling pathway: TP73 hsa04910__46 7.38743553731176e-35 DOWN -12.3168226855261 7.04618851502985e-34 Insulin signaling pathway: FBP1 hsa04151__35 7.66473876572386e-35 UP 12.3138497618753 7.27375966706825e-34 PI3K-Akt signaling pathway: CCND1 hsa04922__51 8.02595204820302e-35 DOWN -12.3101336073117 7.57827331586607e-34 Glucagon signaling pathway: G6PC hsa04152__49 8.71926964565831e-35 UP 12.3034445290973 8.19175383209598e-34 AMPK signaling pathway: GYS1 hsa04066__5 9.47205798465055e-35 UP 12.2967554508828 8.85472485231761e-34 HIF-1 signaling pathway: VEGFA hsa04210__50 9.91781808093423e-35 DOWN -12.2930392963192 9.22553473964129e-34 Apoptosis: SPTA1 hsa04668__102 1.03844133904775e-34 UP 12.2893231417557 9.56485919642509e-34 TNF signaling pathway: AKT3 hsa05210__31 1.03844133904775e-34 UP 12.2893231417557 9.56485919642509e-34 Colorectal cancer: BCL2 hsa04921__58 1.12799051081016e-34 UP 12.2826340635412 1.03389959503038e-33 Oxytocin signaling pathway: MEF2C hsa04340__49 1.17021386272986e-34 UP 12.2796611398904 1.06739410100457e-33 Hedgehog signaling pathway: CCND1 hsa04064__25 1.19191066173289e-34 UP 12.2781746780649 1.07673083336351e-33 NF-kappa B signaling pathway: NFKB2 hsa04210__99 1.19191066173289e-34 UP 12.2781746780649 1.07673083336351e-33 Apoptosis: BID** hsa04923__26 27 1.20285404863738e-34 DOWN -12.2774314471522 1.08141758726777e-33 Regulation of lipolysis in adipocytes: PNPLA2 ABHD5 hsa05166__64 1.23651040763302e-34 UP 12.2752017544141 1.10638240759164e-33 HTLV-I infection: CCNB2 hsa04115__11 12 1.24791699163794e-34 UP 12.2744585235013 1.11129669539701e-33 p53 signaling pathway: CDK2 CCNE1 hsa04920__40 1.47206684951305e-34 DOWN -12.2610803670725 1.30472340105425e-33 Adipocytokine signaling pathway: PPARGC1A hsa04062__53 1.64328358289333e-34 UP 12.2521615961199 1.44963842828947e-33 Chemokine signaling pathway: NFKB1 hsa04610__23 1.70464212617498e-34 DOWN -12.249188672469 1.48977793259664e-33 Complement and coagulation cascades: BDKRB1 hsa04919__25 1.70464212617498e-34 DOWN -12.249188672469 1.48977793259664e-33 Thyroid hormone signaling pathway: MTOR hsa05200__189 1.76827620690506e-34 UP 12.2462157488181 1.53823657072899e-33 Pathways in cancer: BIRC5 hsa04620__77 2.34842482902582e-34 UP 12.223175590524 2.03349781278319e-33 Toll-like receptor signaling pathway: CXCL9 hsa05150__1 2 3 2.54981817205887e-34 UP 12.2164865123095 2.19775612169661e-33 Staphylococcus aureus infection: CFD C3 CFB hsa04917__71 2.74318608550929e-34 UP 12.2105406650078 2.35362860943925e-33 Prolactin signaling pathway: CCND1* hsa04530__13 45 20 2.87136768559408e-34 DOWN -12.2068245104442 2.44131216345306e-33 Tight junction: EPB41 TJP2 ACTB hsa04742__34 2.87136768559408e-34 DOWN -12.2068245104442 2.44131216345306e-33 Taste transduction: GRM1 hsa05169__30 3.32289096793349e-34 UP 12.1949328158408 2.81248294087704e-33 Epstein-Barr virus infection: FGR hsa05210__21 3.47796016713183e-34 UP 12.1912166612772 2.93053235607206e-33 Colorectal cancer: BIRC5 hsa04210__10 3.64021602778328e-34 UP 12.1875005067136 3.05355621259142e-33 Apoptosis: BIRC2 hsa04066__64 3.9876257247097e-34 UP 12.1800681975864 3.33011054965757e-33 HIF-1 signaling pathway: LTBR hsa04931__140 4.21167923291311e-34 UP 12.1756088121101 3.5016572029397e-33 Insulin resistance: G00369 hsa05321__138 4.25021861922289e-34 UP 12.1748655811974 3.51813250463427e-33 Inflammatory bowel disease (IBD): IFNG** hsa04650__14 4.28910831009053e-34 UP 12.1741223502847 3.53475198011408e-33 Natural killer cell mediated cytotoxicity: CSF2 hsa04210__85 4.78428836918303e-34 UP 12.1652035793321 3.92562351340389e-33 Apoptosis: FASLG* hsa04210__63 5.89749921721273e-34 UP 12.1481092683397 4.81800044745336e-33 Apoptosis: FAS* hsa04668__128 6.22798127552537e-34 UP 12.1436498828634 5.06596398991869e-33 TNF signaling pathway: CHUK* hsa05168__106 134 6.69740393608766e-34 DOWN -12.1377040355616 5.42431982582272e-33 Herpes simplex infection: SRSF8 C1QBP hsa04612__17 28 7.07238475124836e-34 UP 12.1332446500853 5.70343817493376e-33 Antigen processing and presentation: CD4 HLA-DMA hsa05215__39 7.60498532707448e-34 UP 12.1272988027836 6.10673821776622e-33 Prostate cancer: RB1 hsa04660__30 8.03041050614115e-34 UP 12.1228394173073 6.42091120895286e-33 T cell receptor signaling pathway: CD40LG hsa05160__7 8.55669718358771e-34 UP 12.1176368009183 6.81272627455988e-33 Hepatitis C: IRF3 hsa04015__17 8.95345672506521e-34 UP 12.1139206463547 7.09854227274158e-33 Rap1 signaling pathway: ACTB hsa04668__153 1.0072627004837e-33 UP 12.1042586444894 7.95229669835658e-33 TNF signaling pathway: MAPK14* hsa05152__77 1.08293127067957e-33 UP 12.0983127971877 8.51392409040552e-33 Tuberculosis: IL12A hsa04750__44 1.19624588108018e-33 UP 12.0901372571478 9.32674693174134e-33 Inflammatory mediator regulation of TRP channels: TRPA1 hsa04750__63 1.19624588108018e-33 UP 12.0901372571478 9.32674693174134e-33 Inflammatory mediator regulation of TRP channels: TRPA1* hsa05152__97 1.29771558361591e-33 UP 12.0834481789334 1.00760643868359e-32 Tuberculosis: IL18 hsa05211__3 1.30950134481256e-33 UP 12.0827049480207 1.01257326209992e-32 Renal cell carcinoma: VEGFA hsa04931__35 1.32139341833726e-33 UP 12.081961717108 1.01758124305562e-32 Insulin resistance: C00369 hsa04066__11 1.33339275654176e-33 UP 12.0812184861952 1.02263060797631e-32 HIF-1 signaling pathway: SLC2A1 hsa04211__42 1.40769575257703e-33 DOWN -12.0767591007189 1.07522777198871e-32 Longevity regulating pathway - mammal: PPARGC1A hsa04620__19 1.44637510203908e-33 UP 12.0745294079808 1.1002991160856e-32 Toll-like receptor signaling pathway: CXCL10 hsa04210__3 1.48610990699593e-33 UP 12.0722997152426 1.12596794969571e-32 Apoptosis: BCL2L1 hsa04010__62 1.73263481777202e-33 UP 12.0596647897265 1.30747824200547e-32 MAPK signaling pathway: MEF2C hsa04742__8 1.79628846366873e-33 UP 12.0566918660756 1.34472623198677e-32 Taste transduction: PLCB2 hsa04014__27 1.79630805869441e-33 UP 12.0566918660756 1.34472623198677e-32 Ras signaling pathway: ABL1 hsa04917__40 1.87917697368866e-33 DOWN -12.052975711512 1.40117997363531e-32 Prolactin signaling pathway: TH hsa04210__73 1.89620086374407e-33 UP 12.0522324805993 1.40828514742099e-32 Apoptosis: TRAF1 hsa05132__55 1.98364546903922e-33 UP 12.0485163260357 1.46742906941917e-32 Salmonella infection: IL18 hsa04380__48 2.01973444568238e-33 UP 12.0470298642103 1.48826706801458e-32 Osteoclast differentiation: NFATC1 hsa04660__44 2.39681104077564e-33 UP 12.0329084768687 1.75922185375681e-32 T cell receptor signaling pathway: PAK4 hsa04350__27 2.50716277332353e-33 UP 12.0291923223051 1.83305791870619e-32 TGF-beta signaling pathway: ACVR2A* hsa04015__30 2.52983130635733e-33 UP 12.0284490913924 1.84246241265326e-32 Rap1 signaling pathway: ITGAL hsa04210__70 2.59906552407468e-33 UP 12.0262193986543 1.88557688020707e-32 Apoptosis: CFLAR* hsa04520__7 68 2.8694125074838e-33 DOWN -12.0180438586144 2.07370234675464e-32 Adherens junction: CDH1 CTNNB1 hsa04621__34 35 3.02846219259241e-33 UP 12.0135844731381 2.18026071259814e-32 NOD-like receptor signaling pathway: CASP1 PYCARD hsa05168__29 3.16766984754808e-33 UP 12.0098683185745 2.27177543646673e-32 Herpes simplex infection: IKBKG hsa04064__52 3.25422594778228e-33 UP 12.0076386258364 2.32497739767411e-32 NF-kappa B signaling pathway: TRAF1 hsa04620__66 3.28359680702891e-33 UP 12.0068953949237 2.33707515166944e-32 Toll-like receptor signaling pathway: CASP8 hsa05110__14 3.37329838224435e-33 DOWN -12.0046657021855 2.37394294390904e-32 Vibrio cholerae infection: C00238* hsa05110__15 3.37329838224435e-33 DOWN -12.0046657021855 2.37394294390904e-32 Vibrio cholerae infection: C01330 hsa05110__16 3.37329838224435e-33 DOWN -12.0046657021855 2.37394294390904e-32 Vibrio cholerae infection: C00698 hsa04620__18 3.40373645332968e-33 UP 12.0039224712728 2.38642567007704e-32 Toll-like receptor signaling pathway: CXCL11 hsa05222__44 3.65726718960446e-33 UP 11.9979766239711 2.55464871719955e-32 Small cell lung cancer: RB1 hsa04390__13 3.92954442106373e-33 UP 11.9920307766693 2.73467183969584e-32 Hippo signaling pathway: BIRC5 hsa04064__142 4.25998112235113e-33 UP 11.9853416984549 2.95369170808036e-32 NF-kappa B signaling pathway: NFKB2* hsa05110__17 4.78656239403066e-33 DOWN -11.9756796965896 3.30659953617045e-32 Vibrio cholerae infection: C00698* hsa04950__7 5.18850230411122e-33 DOWN -11.9689906183752 3.57113400345238e-32 Maturity onset diabetes of the young: FOXA3 hsa05219__19 5.37773629979496e-33 DOWN -11.9660176947243 3.68787098807107e-32 Bladder cancer: TP53 hsa05164__90 6.84719704927551e-33 DOWN -11.945950460081 4.67850300203225e-32 Influenza A: MAPK1 hsa04152__58 6.97071413875504e-33 UP 11.9444639982555 4.72850969917715e-32 AMPK signaling pathway: SCD hsa04713__56 6.97071413875504e-33 DOWN -11.9444639982555 4.72850969917715e-32 Circadian entrainment: KCNJ3 hsa04670__39 7.22442534628423e-33 UP 11.9414910746047 4.8829838941252e-32 Leukocyte transendothelial migration: MAPK14 hsa04666__27 7.35469886058957e-33 UP 11.9400046127792 4.95321833657627e-32 Fc gamma R-mediated phagocytosis: ARPC5 hsa05200__48 9.1123333948009e-33 DOWN -11.9221670708741 6.11502658886817e-32 Pathways in cancer: MTOR hsa04668__36 9.96244768718459e-33 UP 11.9147347617469 6.66172213673304e-32 TNF signaling pathway: CREB3 hsa04728__24 1.07946480913299e-32 UP 11.9080456835325 7.19260417149253e-32 Dopaminergic synapse: SLC6A3 hsa04014__68 1.14893329964969e-32 UP 11.9028430671434 7.62842992947618e-32 Ras signaling pathway: RALGDS* hsa04610__52 1.30146486004418e-32 UP 11.8924378343654 8.61074814092614e-32 Complement and coagulation cascades: CPB2 hsa04151__34 1.61113213399337e-32 UP 11.8746002924602 1.06221658939422e-31 PI3K-Akt signaling pathway: GYS1 hsa04668__38 1.66942764976911e-32 UP 11.8716273688094 1.09680229157908e-31 TNF signaling pathway: CEBPB hsa04520__58 1.85426741732343e-32 DOWN -11.8627085978568 1.21399598506994e-31 Adherens junction: CDH1* hsa03320__37 1.87374165540556e-32 DOWN -11.8619653669441 1.2182562527706e-31 PPAR signaling pathway: HMGCS2 hsa05200__65 1.87374165540556e-32 UP 11.8619653669441 1.2182562527706e-31 Pathways in cancer: STK4 hsa05100__15 2.08429408612938e-32 DOWN -11.8530465959915 1.3504788233921e-31 Bacterial invasion of epithelial cells: CTNNA1 hsa05200__75 2.10286578407782e-32 UP 11.8523033650788 1.35782983102482e-31 Pathways in cancer: MAPK8 hsa04010__63 2.14050357001803e-32 UP 11.8508169032533 1.37739938632325e-31 MAPK signaling pathway: MAX hsa04933__28 2.48865613759979e-32 UP 11.8381819777372 1.59596753670649e-31 AGE-RAGE signaling pathway in diabetic complications: VCAM1 hsa05140__43 2.53314611678391e-32 UP 11.8366955159117 1.61897331749557e-31 Leishmaniasis: MAPK14 hsa04923__43 2.76772340339372e-32 UP 11.8292632067846 1.76289907626332e-31 Regulation of lipolysis in adipocytes: C00219 hsa04922__37 2.89297695263324e-32 DOWN -11.825547052221 1.83645395067495e-31 Glucagon signaling pathway: PYGB hsa04151__98 2.91869501636495e-32 UP 11.8248038213083 1.84654139250833e-31 PI3K-Akt signaling pathway: BCL2L1* hsa04922__59 3.13278132776956e-32 DOWN -11.8188579740066 1.97533426673792e-31 Glucagon signaling pathway: CPT1C hsa04931__104 3.42243607612951e-32 UP 11.8114256648794 2.1507549789456e-31 Insulin resistance: C00369* hsa04064__4 3.70578067244924e-32 UP 11.804736586665 2.32105396117738e-31 NF-kappa B signaling pathway: BIRC2 hsa04668__48 3.90749623754563e-32 UP 11.8002772011887 2.43926426257417e-31 TNF signaling pathway: CASP3 hsa05200__209 4.19350374728985e-32 UP 11.7943313538869 2.60913693415816e-31 Pathways in cancer: FIGF** hsa05200__219 4.38271605008134e-32 UP 11.7906151993234 2.71786252742668e-31 Pathways in cancer: MYC** hsa04151__96 4.4607531008354e-32 UP 11.7891287374979 2.75715627515451e-31 PI3K-Akt signaling pathway: BCL2 hsa04610__11 4.78694087580978e-32 UP 11.7831828901962 2.94906947726117e-31 Complement and coagulation cascades: F2R hsa05110__50 5.70962942546738e-32 DOWN -11.7683182719419 3.50601100995203e-31 Vibrio cholerae infection: ACTB hsa03320__22 5.9667886578513e-32 DOWN -11.7646021173783 3.65198563130378e-31 PPAR signaling pathway: ACADM hsa04620__76 6.01956158610356e-32 UP 11.7638588864656 3.67232344814564e-31 Toll-like receptor signaling pathway: CCL3L3 hsa04919__30 6.69016391176295e-32 DOWN -11.754940115513 4.06822588679695e-31 Thyroid hormone signaling pathway: MYH6 hsa05166__32 6.74928656064802e-32 UP 11.7541968846003 4.09093853143795e-31 HTLV-I infection: STAT5A hsa04210__24 6.86909261626191e-32 UP 11.7527104227749 4.15016881863541e-31 Apoptosis: CASP10 hsa05134__71 6.92978509862359e-32 UP 11.7519671918621 4.17341865394671e-31 Legionellosis: CXCL8 hsa04660__56 7.50054117014633e-32 UP 11.7452781136477 4.50272104111979e-31 T cell receptor signaling pathway: CD3E hsa04530__7 52 7.63358218822139e-32 DOWN -11.7437916518223 4.5679939272828e-31 Tight junction: PARD6A MPP5 hsa04066__55 7.9765241308608e-32 UP 11.7400754972587 4.74300279806565e-31 HIF-1 signaling pathway: ANGPT1 hsa04915__30 7.9765241308608e-32 DOWN -11.7400754972587 4.74300279806565e-31 Estrogen signaling pathway: CREB3* hsa04742__31 8.18958704178867e-32 DOWN -11.7378458045205 4.85433250836622e-31 Taste transduction: C00076* hsa04064__51 8.33475858552684e-32 UP 11.7363593426951 4.92484634660532e-31 NF-kappa B signaling pathway: TNFAIP3 hsa04730__30 8.48248487970943e-32 DOWN -11.7348728808697 4.99642291190408e-31 Long-term depression: C00025* hsa04730__20 9.0998417803222e-32 DOWN -11.728927033568 5.34331334538294e-31 Long-term depression: C00025 hsa03460__48 9.42504640848621e-32 UP 11.7259541099171 5.4998950936477e-31 Fanconi anemia pathway: RAD51 hsa04064__3 9.42504640848621e-32 UP 11.7259541099171 5.4998950936477e-31 NF-kappa B signaling pathway: BCL2 hsa04540__22 9.5075064560515e-32 DOWN -11.7252108790044 5.53083734703429e-31 Gap junction: C00547 hsa05010__47 1.00221575042572e-31 DOWN -11.7207514935281 5.81223270077139e-31 Alzheimer's disease: C00533 hsa04010__15 1.01995564785206e-31 UP 11.7192650317026 5.89691280712007e-31 MAPK signaling pathway: NFKB1 hsa05321__75 1.02894215792203e-31 UP 11.7185218007899 5.93062059734814e-31 Inflammatory bowel disease (IBD): IL10 hsa04668__20 1.11344126106218e-31 UP 11.7118327225755 6.39803097717378e-31 TNF signaling pathway: IKBKG hsa04664__46 1.133135007748e-31 UP 11.7103462607501 6.49134353523931e-31 Fc epsilon RI signaling pathway: PLA2G4B hsa04510__47 1.19431525061966e-31 UP 11.7058868752738 6.82102843742963e-31 Focal adhesion: CCND1 hsa05164__77 1.21542877094856e-31 DOWN -11.7044004134483 6.92057775943136e-31 Influenza A: CASP9 hsa05168__92 93 1.22612408213332e-31 UP 11.7036571825356 6.9603841399653e-31 Herpes simplex infection: IRF9 STAT1 hsa04910__43 1.29228671388954e-31 DOWN -11.6991977970593 7.31387570903149e-31 Insulin signaling pathway: G6PC hsa04670__14 1.33835220725383e-31 UP 11.6962248734085 7.55184323552536e-31 Leukocyte transendothelial migration: SIPA1 hsa05164__35 1.52608860301536e-31 UP 11.6850764097177 8.58539067384989e-31 Influenza A: IL18 hsa04064__137 1.55301962300656e-31 UP 11.6835899478923 8.7108175272517e-31 NF-kappa B signaling pathway: ICAM1 hsa03460__7 1.66554431167403e-31 UP 11.6776441005906 9.28652154787985e-31 Fanconi anemia pathway: FANCI hsa05205__150 1.66554431167403e-31 DOWN -11.6776441005906 9.28652154787985e-31 Proteoglycans in cancer: PRKCA hsa05162__13 1.7552162167226e-31 UP 11.6731847151143 9.75754813970938e-31 Measles: IRF7 hsa05168__122 2.0901788950404e-31 UP 11.6583200968599 1.1585386854811e-30 Herpes simplex infection: CASP3 hsa04390__77 2.32086256385368e-31 UP 11.6494013259074 1.28261786984737e-30 Hippo signaling pathway: CCND1 hsa04976__41 2.36169466877596e-31 UP 11.6479148640819 1.30135609461291e-30 Bile secretion: CYP7A1 hsa04933__65 2.98802269846381e-31 UP 11.6278476294386 1.64166510246009e-30 AGE-RAGE signaling pathway in diabetic complications: COL1A1 hsa04660__35 3.04049576194542e-31 UP 11.6263611676132 1.6656243547217e-30 T cell receptor signaling pathway: NFATC1 hsa04012__25 3.06707432297779e-31 UP 11.6256179367005 1.67530018978932e-30 ErbB signaling pathway: CDKN1B hsa04622__21 22 23 3.23145925670495e-31 UP 11.6211585512242 1.75997447633293e-30 RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG hsa04066__46 3.34587858183756e-31 UP 11.6181856275733 1.81702481366265e-30 HIF-1 signaling pathway: ENO1 hsa04152__54 3.43432423842375e-31 DOWN -11.6159559348351 1.85968162651246e-30 AMPK signaling pathway: SLC2A4* hsa05211__49 3.81192484704252e-31 UP 11.6070371638826 2.05822034126232e-30 Renal cell carcinoma: TGFA* hsa05016__52 4.65456686488773e-31 UP 11.5899428528901 2.49883746832116e-30 Huntington's disease: CASP3 hsa05160__12 13 14 4.65456686488773e-31 UP 11.5899428528901 2.49883746832116e-30 Hepatitis C: IKBKG CHUK IKBKB hsa05200__224 4.7360413742254e-31 UP 11.5884563910647 2.52813117675271e-30 Pathways in cancer: MYC*** hsa05221__12 4.7360413742254e-31 UP 11.5884563910647 2.52813117675271e-30 Acute myeloid leukemia: MYC hsa05133__59 4.8609149527649e-31 UP 11.5862266983265 2.58743886579186e-30 Pertussis: C3 hsa05200__220 4.9032615263757e-31 UP 11.5854834674138 2.60260689493219e-30 Pathways in cancer: CSF1R* hsa05130__55 6.58298000429854e-31 UP 11.5602136163815 3.48434350086675e-30 Pathogenic Escherichia coli infection: ACTB hsa04370__36 6.64020113729254e-31 UP 11.5594703854687 3.50475784746424e-30 VEGF signaling pathway: NOS3 hsa05161__188 6.93379752994579e-31 UP 11.5557542309052 3.64946934419276e-30 Hepatitis B: IFNB1 hsa04210__51 7.36659920844874e-31 DOWN -11.5505516145162 3.86643572979754e-30 Apoptosis: LMNA hsa04740__21 7.49510995996208e-31 DOWN -11.5490651526907 3.92292802639798e-30 Olfactory transduction: PDE1A hsa04151__97 7.5601973919733e-31 UP 11.548321921778 3.94600302764384e-30 PI3K-Akt signaling pathway: MCL1 hsa05200__214 7.69206016387091e-31 UP 11.5468354599526 4.00370666147187e-30 Pathways in cancer: CSF3R hsa04390__75 8.17181547793773e-31 DOWN -11.5416328435636 4.24166886271961e-30 Hippo signaling pathway: NKD1 hsa05166__132 136 8.53257061922756e-31 UP 11.537916689 4.41672181639906e-30 HTLV-I infection: CREBBP TP53 hsa04064__50 9.30217933346854e-31 UP 11.5304843798728 4.8018667493372e-30 NF-kappa B signaling pathway: NFKBIA* hsa04064__2 9.79661780896564e-31 UP 11.5260249943965 5.04324516795793e-30 NF-kappa B signaling pathway: BCL2L1 hsa05205__103 1.02285128954883e-30 UP 11.522308839833 5.25119555481488e-30 Proteoglycans in cancer: CCND1 hsa04742__54 1.06736220463476e-30 DOWN -11.5185926852694 5.44992821333887e-30 Taste transduction: P2RX2* hsa04742__40 1.06736220463476e-30 DOWN -11.5185926852694 5.44992821333887e-30 Taste transduction: P2RX2 hsa04933__22 1.16408787661306e-30 UP 11.5111603761422 5.9276995126177e-30 AGE-RAGE signaling pathway in diabetic complications: EDN1 hsa04620__87 1.40694232250047e-30 UP 11.4948092960625 7.14498547021182e-30 Toll-like receptor signaling pathway: CCL4L1 hsa04014__58 59 1.57343328306718e-30 UP 11.4851472941972 7.9689518568281e-30 Ras signaling pathway: STK4 STK4 hsa04210__75 1.61455018520548e-30 UP 11.482917601459 8.15521451075566e-30 Apoptosis: BAK1* hsa03460__28 1.72948306128625e-30 UP 11.4769717541573 8.71232887977711e-30 Fanconi anemia pathway: RAD51C hsa04962__22 1.74440907217701e-30 DOWN -11.4762285232446 8.76402311930645e-30 Vasopressin-regulated water reabsorption: ARHGDIA hsa05161__32 1.77464573539082e-30 DOWN -11.4747420614191 8.89215823146492e-30 Hepatitis B: STAT3 hsa04650__15 1.91727707798457e-30 UP 11.4680529832047 9.58128624875798e-30 Natural killer cell mediated cytotoxicity: TNF hsa04064__131 2.10713619298803e-30 UP 11.4598774431648 1.04743621868373e-29 NF-kappa B signaling pathway: CCL4L1 hsa04064__132 2.10713619298803e-30 UP 11.4598774431648 1.04743621868373e-29 NF-kappa B signaling pathway: VCAM1 hsa04071__48 2.43780822286174e-30 DOWN -11.4472425176487 1.20861257275916e-29 Sphingolipid signaling pathway: SMPD1 hsa04350__10 2.48002615690201e-30 DOWN -11.4457560558232 1.22630767074181e-29 TGF-beta signaling pathway: SMAD4 hsa05200__197 2.52290016967437e-30 UP 11.4442695939978 1.24423344325936e-29 Pathways in cancer: CCND1** hsa04610__44 2.54461223514853e-30 UP 11.4435263630851 1.25165612299584e-29 Complement and coagulation cascades: C3 hsa05169__64 2.56650974718256e-30 UP 11.4427831321724 1.25913102218173e-29 Epstein-Barr virus infection: NFKB2 hsa05150__69 3.31796185063572e-30 UP 11.4204862047909 1.6235547701418e-29 Staphylococcus aureus infection: FPR2 hsa04933__59 3.43340991733899e-30 UP 11.41751328114 1.67568239861817e-29 AGE-RAGE signaling pathway in diabetic complications: SERPINE1 hsa03320__21 3.49262021157582e-30 DOWN -11.4160268193146 1.70016408744844e-29 PPAR signaling pathway: ACAA1 hsa05110__46 4.07323858252099e-30 DOWN -11.4026486628857 1.97767837120334e-29 Vibrio cholerae infection: PLCG1 hsa05200__225 4.14339205533133e-30 UP 11.4011622010603 2.00139683083999e-29 Pathways in cancer: PPARD hsa05221__11 4.14339205533133e-30 UP 11.4011622010603 2.00139683083999e-29 Acute myeloid leukemia: PPARD hsa05110__51 4.62954150266862e-30 UP 11.391500199195 2.23048935474727e-29 Vibrio cholerae infection: PDIA4 hsa04022__19 4.9988619487713e-30 DOWN -11.3848111209805 2.39613816370951e-29 cGMP-PKG signaling pathway: CNGB1 hsa04919__31 4.9988619487713e-30 DOWN -11.3848111209805 2.39613816370951e-29 Thyroid hormone signaling pathway: ATP2A2 hsa04650__40 5.44358948923604e-30 UP 11.3773788118534 2.60267293900115e-29 Natural killer cell mediated cytotoxicity: TNFRSF10D hsa04062__33 6.34528248573569e-30 UP 11.3640006554245 3.02608776413638e-29 Chemokine signaling pathway: WAS hsa04014__45 6.3995109661848e-30 UP 11.3632574245118 3.04422306467373e-29 Ras signaling pathway: RAB5A hsa04360__82 6.90873459985754e-30 DOWN -11.3565683462973 3.26990234587716e-29 Axon guidance: ILK hsa05161__66 67 6.90873459985754e-30 DOWN -11.3565683462973 3.26990234587716e-29 Hepatitis B: NFKB1 NFKBIA hsa04152__68 6.96774028858413e-30 DOWN -11.3558251153846 3.28954371915819e-29 AMPK signaling pathway: PPARGC1A** hsa05200__96 7.02724607639963e-30 UP 11.3550818844719 3.30932214976313e-29 Pathways in cancer: C00416 hsa04668__47 7.14777480601881e-30 UP 11.3535954226465 3.35766721512733e-29 TNF signaling pathway: CASP7 hsa04668__116 7.65075219175159e-30 UP 11.3476495753447 3.5849783960851e-29 TNF signaling pathway: PGAM5 hsa04742__46 7.84783732853197e-30 UP 11.3454198826066 3.66818068166954e-29 Taste transduction: P2RY1 hsa04115__9 9.78666005979573e-30 DOWN -11.326095878876 4.55176590404856e-29 p53 signaling pathway: RPRM hsa05166__83 9.78666005979573e-30 UP 11.326095878876 4.55176590404856e-29 HTLV-I infection: NFKB2 hsa04919__45 9.95409153125085e-30 DOWN -11.3246094170506 4.61820691042478e-29 Thyroid hormone signaling pathway: SLC9A1 hsa05321__152 1.02105828578669e-29 UP 11.3223797243124 4.72553822412114e-29 Inflammatory bowel disease (IBD): FOXP3* hsa05145__23 1.0562800379919e-29 UP 11.3194068006615 4.87653609677343e-29 Toxoplasmosis: CIITA hsa04917__65 1.26194781371126e-29 DOWN -11.3037989514945 5.81176456363591e-29 Prolactin signaling pathway: CYP17A1 hsa05014__53 1.32769114381617e-29 DOWN -11.2993395660182 6.09958840887674e-29 Amyotrophic lateral sclerosis (ALS): RAB5A hsa04370__39 1.40869778326184e-29 UP 11.2941369496292 6.45595886524143e-29 VEGF signaling pathway: RAC1 hsa04261__52 1.49460674197229e-29 DOWN -11.2889343332402 6.83300746512394e-29 Adrenergic signaling in cardiomyocytes: MAPK14 hsa05223__24 1.58571223005154e-29 UP 11.2837317168512 7.23192543754088e-29 Non-small cell lung cancer: STK4 hsa04152__82 1.65414107567396e-29 DOWN -11.2800155622876 7.52574111668611e-29 AMPK signaling pathway: HMGCR hsa04660__40 41 1.7401332017636e-29 UP 11.2755561768113 7.89785093264205e-29 T cell receptor signaling pathway: LAT GRAP2 hsa04530__20 62 1.81517110039818e-29 DOWN -11.2718400222477 8.21856987385105e-29 Tight junction: ACTB SHROOM1 hsa05161__100 1.97501255760052e-29 UP 11.2644077131206 8.92078989358502e-29 Hepatitis B: MMP9* hsa04924__49 2.09513638812973e-29 DOWN -11.2592050967316 9.44067451629678e-29 Renin secretion: PDE1A hsa04380__32 2.20385109139161e-29 UP 11.2547457112553 9.90678516919816e-29 Osteoclast differentiation: AKT3 hsa05211__4 2.22250666257018e-29 UP 11.2540024803426 9.96680195458081e-29 Renal cell carcinoma: SLC2A1 hsa05145__13 2.63032591622879e-29 UP 11.2391378620882 1.17675771347474e-28 Toxoplasmosis: GNAI1 hsa04620__20 2.7203916573036e-29 UP 11.2361649384374 1.2112833943302e-28 Toll-like receptor signaling pathway: IFNB1* hsa04660__41 46 2.7203916573036e-29 UP 11.2361649384374 1.2112833943302e-28 T cell receptor signaling pathway: GRAP2 LCP2 hsa04010__58 2.86125850884707e-29 UP 11.2317055529611 1.27099402792521e-28 MAPK signaling pathway: CDC25B hsa05205__120 2.95916678826088e-29 DOWN -11.2287326293102 1.3113854705524e-28 Proteoglycans in cancer: PLAU hsa04917__46 3.30090680829849e-29 DOWN -11.2190706274449 1.45938915124538e-28 Prolactin signaling pathway: GCK hsa04370__28 3.38516558986441e-29 UP 11.2168409347068 1.49312820266555e-28 VEGF signaling pathway: SHC2 hsa04670__2 4.31813149897753e-29 UP 11.195287238238 1.90018011395287e-28 Leukocyte transendothelial migration: MMP2 hsa05169__31 4.77508918255403e-29 UP 11.1863684672854 2.09635340514463e-28 Epstein-Barr virus infection: MYC hsa04064__113 4.93782555968336e-29 UP 11.1833955436346 2.16274457497553e-28 NF-kappa B signaling pathway: CFLAR hsa04922__50 5.10606325376052e-29 DOWN -11.1804226199837 2.23123089623628e-28 Glucagon signaling pathway: PCK1 hsa04151__63 5.36913988731483e-29 DOWN -11.1759632345074 2.34074567245118e-28 PI3K-Akt signaling pathway: CASP9 hsa04650__16 5.6931003273343e-29 UP 11.1707606181184 2.47623507293082e-28 Natural killer cell mediated cytotoxicity: PRKCA hsa05200__212 5.88685170786505e-29 UP 11.1677876944675 2.55459454020287e-28 Pathways in cancer: CCND1*** hsa04062__35 36 37 6.08714357620745e-29 UP 11.1648147708167 2.63542460361608e-28 Chemokine signaling pathway: PARD3 PRKCZ TIAM1 hsa05161__213 6.29419489038376e-29 UP 11.1618418471658 2.71880280437496e-28 Hepatitis B: E2F1 hsa04062__44 6.45405507141676e-29 UP 11.1596121544277 2.78146088972296e-28 Chemokine signaling pathway: MAPK1 hsa04152__38 6.74348218938241e-29 UP 11.1551527689514 2.89954302834086e-28 AMPK signaling pathway: PFKL hsa04912__14 6.78595852183247e-29 UP 11.1551527689514 2.91114521975416e-28 GnRH signaling pathway: ATF4 hsa05214__52 6.90031326503102e-29 UP 11.1536663071259 2.95345982346088e-28 Glioma: E2F1* hsa04151__101 7.01657969214556e-29 UP 11.1521798453005 2.99639846398671e-28 PI3K-Akt signaling pathway: PKN3 hsa04071__69 8.43113057434563e-29 UP 11.1358287652207 3.59231164380849e-28 Sphingolipid signaling pathway: RAC1 hsa04540__18 19 8.64476715356869e-29 UP 11.1335990724826 3.67500395510307e-28 Gap junction: GJA1 GJA1*** hsa03320__43 9.08828299996596e-29 UP 11.1291396870063 3.8548270331684e-28 PPAR signaling pathway: ILK hsa05162__81 1.0128169256107e-28 UP 11.119477685141 4.28622298023085e-28 Measles: TNFRSF10D hsa03320__20 1.20628068240006e-28 DOWN -11.103869835974 5.09348629714541e-28 PPAR signaling pathway: SCP2 hsa04370__37 1.4009960023549e-28 DOWN -11.0904916795451 5.90240244041447e-28 VEGF signaling pathway: CASP9 hsa04024__92 1.560720326423e-28 UP 11.0808296776798 6.56061184194367e-28 cAMP signaling pathway: GRIN3A hsa04917__57 1.57372992870213e-28 DOWN -11.0800864467671 6.60053244649845e-28 Prolactin signaling pathway: ESR1 hsa04660__14 1.60007273628197e-28 UP 11.0785999849416 6.69607276497509e-28 T cell receptor signaling pathway: NFKB1 hsa04110__10 11 12 13 14 9 15 16 17 18 19 20 1.61340771315126e-28 UP 11.0778567540289 6.73687354002492e-28 Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 hsa05152__98 1.70989045681665e-28 UP 11.0726541376399 7.12391168150442e-28 Tuberculosis: IL23A hsa04666__50 52 1.72413309263068e-28 UP 11.0719109067272 7.16735858640055e-28 Fc gamma R-mediated phagocytosis: DNM2 AMPH hsa04630__35 1.73849341048427e-28 DOWN -11.0711676758145 7.21110180640165e-28 Jak-STAT signaling pathway: MTOR hsa04340__51 1.8423927348628e-28 UP 11.0659650594255 7.62523336741673e-28 Hedgehog signaling pathway: CCND1* hsa04933__56 2.08623185955304e-28 UP 11.0548165957347 8.61544981120913e-28 AGE-RAGE signaling pathway in diabetic complications: NFATC1 hsa05205__369 2.34258805204406e-28 DOWN -11.0444113629567 9.65290120568157e-28 Proteoglycans in cancer: HOXD10 hsa04913__21 2.74113768587434e-28 DOWN -11.0302899756151 1.12458465322225e-27 Ovarian steroidogenesis: CYP17A1 hsa04913__22 2.74113768587434e-28 DOWN -11.0302899756151 1.12458465322225e-27 Ovarian steroidogenesis: CYP17A1* hsa04066__42 2.80993925540655e-28 UP 11.028060282877 1.150299751832e-27 HIF-1 signaling pathway: HK1 hsa04211__38 2.92843534247549e-28 UP 11.0243441283134 1.19620217576336e-27 Longevity regulating pathway - mammal: BAX hsa04622__5 33 3.05188663405837e-28 UP 11.0206279737498 1.24123268082157e-27 RIG-I-like receptor signaling pathway: MAVS TMEM173 hsa04931__87 3.05188663405837e-28 DOWN -11.0206279737498 1.24123268082157e-27 Insulin resistance: C00031* hsa05211__2 3.20685890101961e-28 UP 11.0161685882735 1.30144446544619e-27 Renal cell carcinoma: TGFB1 hsa05164__31 32 33 3.28717530058149e-28 UP 11.0139388955354 1.33116430814496e-27 Influenza A: NLRP3 PYCARD CASP1 hsa05222__19 3.34194669497139e-28 DOWN -11.0124524337099 1.35043394405403e-27 Small cell lung cancer: CASP9 hsa04670__28 41 49 3.5699210241496e-28 UP 11.0065065864082 1.43945957175474e-27 Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1 hsa04211__56 3.72017015538045e-28 DOWN -11.0027904318446 1.49683077558027e-27 Longevity regulating pathway - mammal: CAT hsa05218__9 3.84487191678461e-28 UP 10.9998175081938 1.54369964351245e-27 Melanoma: CCND1 hsa04020__8 3.90876881743298e-28 DOWN -10.9983310463683 1.56600780553445e-27 Calcium signaling pathway: PDE1A hsa04621__21 31 41 4.57082432638548e-28 UP 10.9842096590267 1.82735721474007e-27 NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1 hsa04622__11 4.60859670525386e-28 UP 10.983466428114 1.83854632891125e-27 RIG-I-like receptor signaling pathway: IRF7 hsa05162__23 4.92213517443245e-28 UP 10.9775205808123 1.9594686425336e-27 Measles: IRF3 hsa05169__103 5.04509003483545e-28 UP 10.9752908880741 2.0041700159526e-27 Epstein-Barr virus infection: NFKB1* hsa04670__86 5.12798642777505e-28 UP 10.9738044262487 2.03280305860534e-27 Leukocyte transendothelial migration: ACTB hsa04015__67 5.61406585392648e-28 UP 10.9656288862088 2.22080626095323e-27 Rap1 signaling pathway: AKT3 hsa04670__15 5.79743623207469e-28 UP 10.962655962558 2.2885257731236e-27 Leukocyte transendothelial migration: PECAM1 hsa04066__52 7.60577228466652e-28 UP 10.9381293424383 2.99606836957828e-27 HIF-1 signaling pathway: FLT1 hsa05205__236 7.66836431799997e-28 DOWN -10.9373861115256 3.01440513672007e-27 Proteoglycans in cancer: ITGAV hsa05164__19 8.1210466973617e-28 UP 10.9321834951366 3.18568825560389e-27 Influenza A: NFKB1 hsa05166__5 8.67092571804017e-28 UP 10.9262376478349 3.39430613004114e-27 HTLV-I infection: SLC2A1 hsa05134__9 1.14504549339931e-27 UP 10.9009677968026 4.47305713533744e-27 Legionellosis: CASP7 hsa04370__25 1.43900845496891e-27 UP 10.8801573312465 5.60974457860288e-27 VEGF signaling pathway: PXN hsa05152__129 1.4867068572455e-27 UP 10.8771844075956 5.78368982352854e-27 Tuberculosis: IFNB1 hsa04066__63 1.49887442492156e-27 UP 10.8764411766829 5.79503095561238e-27 HIF-1 signaling pathway: TIMP1* hsa04066__57 1.49887442492156e-27 UP 10.8764411766829 5.79503095561238e-27 HIF-1 signaling pathway: TIMP1 hsa04151__24 1.49887442492156e-27 UP 10.8764411766829 5.79503095561238e-27 PI3K-Akt signaling pathway: MYC hsa04970__39 1.5110950739255e-27 UP 10.8756979457702 5.83028263635732e-27 Salivary secretion: KCNN4 hsa04380__72 1.70754187352877e-27 UP 10.8645494820795 6.574736025329e-27 Osteoclast differentiation: MAPK1 hsa04550__22 1.80766263390668e-27 UP 10.8593468656905 6.94600836218948e-27 Signaling pathways regulating pluripotency of stem cells: SMAD2 hsa04916__8 1.82243301506026e-27 DOWN -10.8586036347778 6.98847272509843e-27 Melanogenesis: TYR* hsa04370__16 1.86746610293047e-27 UP 10.8563739420396 7.14657598249766e-27 VEGF signaling pathway: HSPB1 hsa05213__29 1.94498634528775e-27 UP 10.852657787476 7.42810842031644e-27 Endometrial cancer: CCND1 hsa04919__99 2.28829695995598e-27 DOWN -10.8377931692217 8.72152127334133e-27 Thyroid hormone signaling pathway: WNT4 hsa05020__59 2.34473382256117e-27 UP 10.8355634764836 8.91853209026809e-27 Prion diseases: CCL5 hsa05162__58 2.40255075467336e-27 UP 10.8333337837454 9.1199855919823e-27 Measles: STAT3 hsa04360__51 2.89539130303529e-27 UP 10.816239472753 1.09686295532325e-26 Axon guidance: FYN hsa04210__61 2.99080023852942e-27 UP 10.8132665491021 1.13072709219251e-26 Apoptosis: APAF1 hsa05132__20 3.1910695310033e-27 UP 10.8073207018004 1.2040200097902e-26 Salmonella infection: ACTB hsa04970__12 4.1318382161296e-27 UP 10.7835373125935 1.55585651465081e-26 Salivary secretion: BEST2 hsa04310__57 4.30453913147905e-27 UP 10.7798211580299 1.61764580560983e-26 Wnt signaling pathway: SIAH1 hsa04623__9 4.41013765553302e-27 UP 10.7775914652917 1.65402168757416e-26 Cytosolic DNA-sensing pathway: IKBKE hsa04931__124 5.26712476425675e-27 DOWN -10.761240385212 1.97149948845387e-26 Insulin resistance: FOXO1* hsa04722__84 5.48384473500769e-27 UP 10.7575242306484 2.04853762566192e-26 Neurotrophin signaling pathway: NFKB1* hsa05134__6 5.52823816840081e-27 UP 10.7567809997357 2.06102371397324e-26 Legionellosis: IL1B hsa04971__52 53 5.61809684692343e-27 DOWN -10.7552945379103 2.09037702482557e-26 Gastric acid secretion: EZR ACTB hsa03460__25 40 5.84912965976396e-27 UP 10.7515783833467 2.17203846456452e-26 Fanconi anemia pathway: MLH1 PMS2 hsa04062__25 6.18848145427542e-27 UP 10.7463757669577 2.29352202220582e-26 Chemokine signaling pathway: ROCK1 hsa05152__23 6.54734582598936e-27 DOWN -10.7411731505687 2.42174464705394e-26 Tuberculosis: PPP3CA hsa05145__29 6.87125573849655e-27 UP 10.7367137650924 2.53655982959431e-26 Toxoplasmosis: C06314 hsa05215__46 7.446951092032e-27 DOWN -10.7292814559652 2.74369041214277e-26 Prostate cancer: MTOR hsa05014__51 8.74549462928919e-27 UP 10.7144168377109 3.2158090818854e-26 Amyotrophic lateral sclerosis (ALS): DERL1 hsa05169__118 8.95874243480682e-27 UP 10.7121871449727 3.28778848339883e-26 Epstein-Barr virus infection: MDM2 hsa04611__7 9.70749474746173e-27 UP 10.7047548358456 3.55563014239388e-26 Platelet activation: ITPR1 hsa04620__86 1.27483387585401e-26 UP 10.6794849848132 4.66033628935736e-26 Toll-like receptor signaling pathway: IL12A hsa04014__62 1.68652793505138e-26 UP 10.6534719028682 6.14144571697974e-26 Ras signaling pathway: RASSF5 hsa05162__101 1.68652793505138e-26 DOWN -10.6534719028682 6.14144571697974e-26 Measles: CDKN1B hsa05321__95 1.70005051769986e-26 UP 10.6527286719555 6.17871358367125e-26 Inflammatory bowel disease (IBD): SMAD2 hsa04920__12 1.76924447616082e-26 DOWN -10.6490125173919 6.41778063842893e-26 Adipocytokine signaling pathway: C00165 hsa04340__14 1.85608256410837e-26 DOWN -10.6445531319156 6.71980566080854e-26 Hedgehog signaling pathway: PTCH1 hsa04917__33 1.91627395046601e-26 DOWN -10.6415802082647 6.9243822171647e-26 Prolactin signaling pathway: CSN2 hsa05161__214 1.99424092555782e-26 UP 10.6378640537012 7.19228157221334e-26 Hepatitis B: CDKN1B hsa04062__43 2.12557924272149e-26 UP 10.6319182063994 7.63664129459593e-26 Chemokine signaling pathway: STAT1 hsa05142__21 2.12557924272149e-26 UP 10.6319182063994 7.63664129459593e-26 Chagas disease (American trypanosomiasis): TICAM1 hsa04970__45 2.55284185899426e-26 UP 10.614823895407 9.15417910887445e-26 Salivary secretion: KCNMA1 hsa04550__67 2.57326777273084e-26 UP 10.6140806644943 9.20984789516427e-26 Signaling pathways regulating pluripotency of stem cells: MYC* hsa04916__6 2.80856433383056e-26 DOWN -10.6059051244544 1.00328752533605e-25 Melanogenesis: DCT hsa05160__8 2.92245150938832e-26 UP 10.6021889698908 1.04198982659215e-25 Hepatitis C: NFKB1 hsa04012__40 2.96927774874213e-26 UP 10.6007025080654 1.05668047156941e-25 ErbB signaling pathway: ELK1* hsa05161__126 3.16413750433136e-26 UP 10.5947566607636 1.12389685645343e-25 Hepatitis B: MYC* hsa04917__44 3.21480104543912e-26 DOWN -10.5932701989382 1.13973795554342e-25 Prolactin signaling pathway: PRLR** hsa04931__135 3.39853887150543e-26 UP 10.5880675825492 1.20260914115983e-25 Insulin resistance: SREBF1** hsa05150__40 4.07869482305867e-26 UP 10.5709732715567 1.4405766113773e-25 Staphylococcus aureus infection: FCGR1A hsa04917__47 4.74106952012885e-26 DOWN -10.5568518842151 1.67138266947882e-25 Prolactin signaling pathway: INS hsa04390__96 5.01109778741075e-26 DOWN -10.5516492678261 1.76326830384734e-25 Hippo signaling pathway: FGF1 hsa04072__57 5.4234940250128e-26 UP 10.544216958699 1.90481220056057e-25 Phospholipase D signaling pathway: C06124 hsa04024__34 5.59771807181026e-26 UP 10.5412440350481 1.96233437629319e-25 cAMP signaling pathway: ATP2B1 hsa04510__20 4 5 6.10595046614971e-26 UP 10.5330684950082 2.13651413890043e-25 Focal adhesion: VASP ITGB1 ITGA11 hsa04623__25 6.15437215297745e-26 UP 10.5323252640955 2.14945451216443e-25 Cytosolic DNA-sensing pathway: NFKB1* hsa04971__39 6.50407237064347e-26 UP 10.5271226477065 2.26737513625957e-25 Gastric acid secretion: EZR hsa05231__50 6.8194429128414e-26 UP 10.5226632622302 2.37291356170907e-25 Choline metabolism in cancer: WASF2 hsa05152__69 7.37908352067424e-26 UP 10.5152309531031 2.56290165163529e-25 Tuberculosis: HLA-DMA hsa05130__9 7.85937703773967e-26 UP 10.5092851058013 2.72468071105403e-25 Pathogenic Escherichia coli infection: TLR4 hsa05215__14 8.57074559064508e-26 UP 10.5011095657615 2.96582522372415e-25 Prostate cancer: CCND1 hsa04064__115 8.91484618300842e-26 UP 10.4973934111979 3.07922720181486e-25 NF-kappa B signaling pathway: XIAP hsa05200__213 9.19995649158133e-26 UP 10.494420487547 3.17187490783143e-25 Pathways in cancer: CSF2RA hsa04668__141 9.72081046939268e-26 UP 10.489217871158 3.34531188131664e-25 TNF signaling pathway: JUN* hsa04530__30 9.7975659610434e-26 UP 10.4884746402453 3.36556242062167e-25 Tight junction: AKT3 hsa04932__58 9.87492210607693e-26 UP 10.4877314093326 3.38594500680995e-25 Non-alcoholic fatty liver disease (NAFLD): BAX hsa04913__47 1.19236988352273e-25 UP 10.4698938674274 4.07356911116221e-25 Ovarian steroidogenesis: INSR hsa04913__51 1.19236988352273e-25 UP 10.4698938674274 4.07356911116221e-25 Ovarian steroidogenesis: INSR* hsa04210__31 32 33 1.39501688312015e-25 UP 10.4550292491731 4.75723543263657e-25 Apoptosis: TRAF2 RIPK1 TRADD hsa04390__76 1.43945190464087e-25 UP 10.4520563255222 4.89987342177572e-25 Hippo signaling pathway: MYC hsa04380__69 1.50874751126944e-25 UP 10.4475969400459 5.12646758349959e-25 Osteoclast differentiation: NFKB2 hsa04666__29 1.55677105832162e-25 UP 10.4446240163951 5.28009534040853e-25 Fc gamma R-mediated phagocytosis: WAS hsa04390__52 1.56901176524668e-25 UP 10.4438807854823 5.31202361603335e-25 Hippo signaling pathway: ITGB2 hsa04115__39 1.60630912492497e-25 UP 10.4416510927442 5.42851590959355e-25 p53 signaling pathway: BAX hsa04152__89 2.19615823166956e-25 DOWN -10.4119218562356 7.39530702026363e-25 AMPK signaling pathway: CFTR hsa04917__75 2.19615823166956e-25 UP 10.4119218562356 7.39530702026363e-25 Prolactin signaling pathway: CCND1** hsa05200__211 2.31950624593318e-25 UP 10.4067192398466 7.79669451897755e-25 Pathways in cancer: CXCL8 hsa04024__107 64 2.84079999152713e-25 UP 10.3873952361159 9.53189854299905e-25 cAMP signaling pathway: NFKBIA NFKB1 hsa05205__22 2.93070288695409e-25 UP 10.3844223124651 9.81602624703519e-25 Proteoglycans in cancer: PPP1R12A hsa05110__12 2.95360607341637e-25 DOWN -10.3836790815524 9.85759469262763e-25 Vibrio cholerae infection: C00080 hsa05120__35 2.95360607341637e-25 DOWN -10.3836790815524 9.85759469262763e-25 Epithelial cell signaling in Helicobacter pylori infection: C00080 hsa04064__133 3.21767641093862e-25 UP 10.3755035415125 1.07198829364427e-24 NF-kappa B signaling pathway: CXCL2 hsa04666__51 3.2681411104488e-25 UP 10.3740170796871 1.08687383124483e-24 Fc gamma R-mediated phagocytosis: NCF1 hsa04550__62 63 3.50511264700911e-25 UP 10.3673280014726 1.16362308546469e-24 Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4 hsa04115__43 57 3.61582524751205e-25 UP 10.3643550778218 1.19826025398151e-24 p53 signaling pathway: CDK1 CCNB3 hsa04024__93 4.031313361732e-25 UP 10.3539498450437 1.33359820540395e-24 cAMP signaling pathway: ORAI1 hsa05152__120 4.2235499090218e-25 UP 10.3494904595674 1.39473642865588e-24 Tuberculosis: TGFB1 hsa04024__108 4.56433027648078e-25 UP 10.3420581504403 1.5046274718434e-24 cAMP signaling pathway: AMH hsa05145__4 5 5.04836534667904e-25 UP 10.332396148575 1.66127469114009e-24 Toxoplasmosis: MAP3K7 TAB1 hsa04670__73 5.41292633519353e-25 UP 10.3257070703605 1.77812737479522e-24 Leukocyte transendothelial migration: MYL12B* hsa04014__103 5.54015119215922e-25 UP 10.3234773776224 1.81674416929619e-24 Ras signaling pathway: KSR2 hsa05212__54 6.17415682588134e-25 UP 10.3130721448444 2.02112206896011e-24 Pancreatic cancer: C00416 hsa05145__33 6.98713162058332e-25 UP 10.3011804502409 2.27930908247848e-24 Toxoplasmosis: STAT3 hsa05169__125 6.98713162058332e-25 UP 10.3011804502409 2.27930908247848e-24 Epstein-Barr virus infection: STAT3 hsa04973__36 7.09593785209601e-25 UP 10.2996939884155 2.31079154663577e-24 Carbohydrate digestion and absorption: SLC2A2 hsa04350__44 45 7.31861173500129e-25 UP 10.2967210647646 2.37918191177637e-24 TGF-beta signaling pathway: TGFBR2 TGFBR1 hsa04150__31 7.54820711237446e-25 DOWN -10.2937481411138 2.449582239059e-24 mTOR signaling pathway: EIF4E hsa05140__21 7.72507379815496e-25 UP 10.2915184483756 2.5026575287471e-24 Leishmaniasis: NFKB1 hsa04724__26 8.09121749478072e-25 DOWN -10.2870590628993 2.61676379908657e-24 Glutamatergic synapse: PRKACA hsa04114__56 8.47454820841445e-25 DOWN -10.282599677423 2.73602681848982e-24 Oocyte meiosis: REC8 hsa04114__59 8.54016317970472e-25 UP 10.2818564465103 2.75248140903348e-24 Oocyte meiosis: REC8* hsa04530__20 22 1.01962783239735e-24 DOWN -10.2647621355178 3.2806176319771e-24 Tight junction: ACTB MYL12B hsa04933__24 1.03545030632367e-24 UP 10.2632756736924 3.32583098390117e-24 AGE-RAGE signaling pathway in diabetic complications: THBD hsa05169__32 1.04345252399708e-24 DOWN -10.2625324427797 3.34581449247529e-24 Epstein-Barr virus infection: CR2 hsa05160__15 16 1.14439340347875e-24 UP 10.2536136718271 3.66322862885278e-24 Hepatitis C: TRAF6 RIPK1 hsa05216__15 1.19843320558423e-24 UP 10.2491542863508 3.82968706342307e-24 Thyroid cancer: CCND1 hsa04540__10 1.22639357962377e-24 UP 10.2469245936127 3.91238291360452e-24 Gap junction: C00533 hsa04015__82 1.28426757704535e-24 UP 10.2424652081364 4.09006572418341e-24 Rap1 signaling pathway: ITGA2B hsa05166__89 90 1.32434518562518e-24 UP 10.2394922844855 4.21056616546482e-24 HTLV-I infection: CHUK IKBKG hsa05205__319 1.40548249675329e-24 UP 10.2253708971439 4.46098245168824e-24 Proteoglycans in cancer: KDR hsa04621__28 1.47462338985012e-24 UP 10.2290870517075 4.67254190476962e-24 NOD-like receptor signaling pathway: CASP8 hsa05142__18 1.50896058652213e-24 UP 10.2268573589693 4.7732945152779e-24 Chagas disease (American trypanosomiasis): FOS hsa04722__37 1.56795804790808e-24 DOWN -10.2231412044058 4.95158516305762e-24 Neurotrophin signaling pathway: NFKB1 hsa04015__63 1.8137402782125e-24 UP 10.2090198170642 5.70857283544604e-24 Rap1 signaling pathway: GNAI1 hsa04722__50 1.8137402782125e-24 DOWN -10.2090198170642 5.70857283544604e-24 Neurotrophin signaling pathway: RHOA hsa04612__39 1.94312726745425e-24 UP 10.2023307388497 6.10557882198419e-24 Antigen processing and presentation: PSME3 hsa04668__120 2.01891746076772e-24 DOWN -10.1986145842861 6.33313173419456e-24 TNF signaling pathway: DNM1L hsa04115__2 2.08165205461468e-24 UP 10.1956416606353 6.51904035103497e-24 p53 signaling pathway: IGFBP3 hsa04370__14 2.21297180111827e-24 UP 10.1896958133335 6.91875875923666e-24 VEGF signaling pathway: PTGS2 hsa05160__77 2.22995334981693e-24 UP 10.1889525824208 6.96026967492694e-24 Hepatitis C: NFKB1* hsa04350__32 2.33458759133702e-24 UP 10.1844931969445 7.27477625890924e-24 TGF-beta signaling pathway: RPS6KB1 hsa04062__22 41 2.7197543812833e-24 UP 10.1696285786902 8.43303379939162e-24 Chemokine signaling pathway: CRK PTK2B hsa05200__217 2.7197543812833e-24 UP 10.1696285786902 8.43303379939162e-24 Pathways in cancer: E2F1* hsa05211__41 2.7197543812833e-24 UP 10.1696285786902 8.43303379939162e-24 Renal cell carcinoma: PDGFB* hsa04920__31 3.92020323817854e-24 DOWN -10.1339534948799 1.21351925610173e-23 Adipocytokine signaling pathway: AGRP hsa04024__77 3.95012331122208e-24 DOWN -10.1332102639671 1.22077001674117e-23 cAMP signaling pathway: RHOA* hsa04723__73 4.22978788160888e-24 UP 10.1265211857527 1.30291334910542e-23 Retrograde endocannabinoid signaling: MAPK14* hsa04723__68 4.22978788160888e-24 UP 10.1265211857527 1.30291334910542e-23 Retrograde endocannabinoid signaling: MAPK14 hsa04919__40 6.04153417655277e-24 DOWN -10.0915893328551 1.85794479832122e-23 Thyroid hormone signaling pathway: RCAN2 hsa04670__55 7.35481194511332e-24 UP 10.0722653291244 2.25811954981502e-23 Leukocyte transendothelial migration: RAC2 hsa05161__29 7.63802209689666e-24 UP 10.0685491745609 2.34124690376327e-23 Hepatitis B: NFKB1 hsa04620__12 7.69594694403718e-24 UP 10.0678059436481 2.35516031072408e-23 Toll-like receptor signaling pathway: NFKB1 hsa04910__42 7.81310500542808e-24 DOWN -10.0663194818227 2.38712590328445e-23 Insulin signaling pathway: PCK1 hsa04012__24 8.68416798476155e-24 UP 10.0559142490447 2.64038052481666e-23 ErbB signaling pathway: CDKN1A hsa04066__62 8.68416798476155e-24 UP 10.0559142490447 2.64038052481666e-23 HIF-1 signaling pathway: NPPA hsa04380__51 8.68416798476155e-24 UP 10.0559142490447 2.64038052481666e-23 Osteoclast differentiation: FOS* hsa04024__2 1.02510849394016e-23 UP 10.0395631689649 3.11175906318832e-23 cAMP signaling pathway: CACNA1C hsa04622__6 1.11364688392947e-23 UP 10.0313876289251 3.37506854016689e-23 RIG-I-like receptor signaling pathway: NFKB1 hsa05169__45 1.26558933429887e-23 DOWN -10.0187527034089 3.82937577962572e-23 Epstein-Barr virus infection: RB1 hsa05164__78 1.34402704080978e-23 DOWN -10.0128068561072 4.0601717197453e-23 Influenza A: GSK3B hsa04071__57 1.58542749847438e-23 UP 9.99645577602743 4.78173076987698e-23 Sphingolipid signaling pathway: BAX hsa04064__95 1.82814105566028e-23 UP 9.98233438868583 5.50493115959241e-23 NF-kappa B signaling pathway: BCL2L1** hsa04210__106 1.86969063243232e-23 DOWN -9.98010469594769 5.62103791734452e-23 Apoptosis: TUBA1B hsa04670__18 1.89761830948536e-23 UP 9.97861823412225 5.68767147713373e-23 Leukocyte transendothelial migration: CDH5 hsa05014__5 1.89790847054968e-23 UP 9.97861823412225 5.68767147713373e-23 Amyotrophic lateral sclerosis (ALS): TOMM40 hsa04010__86 1.91217512227388e-23 UP 9.97787500320954 5.7213010425997e-23 MAPK signaling pathway: MAP4K2 hsa04921__60 2.12342197163055e-23 UP 9.96746977043152 6.34325895817775e-23 Oxytocin signaling pathway: ELK1 hsa04010__79 2.30547504122355e-23 UP 9.95929423039164 6.87617079755406e-23 MAPK signaling pathway: HSPB1 hsa05134__10 2.48434522997201e-23 UP 9.95186192126449 7.39791551048718e-23 Legionellosis: NFKB1 hsa05200__227 2.82049283007904e-23 DOWN -9.93922699574832 8.38561080335209e-23 Pathways in cancer: FOXO1 hsa04925__5 2.97165680296418e-23 UP 9.93402437935931 8.8210791986883e-23 Aldosterone synthesis and secretion: KCNK3 hsa04068__41 3.0163011442582e-23 UP 9.93253791753387 8.93947925877153e-23 FoxO signaling pathway: CDKN2B hsa05132__54 3.06160949451528e-23 UP 9.93105145570844 9.05947124440035e-23 Salmonella infection: IL1B hsa04066__58 3.50092576601779e-23 UP 9.91767329927956 1.03431438904834e-22 HIF-1 signaling pathway: EDN1 hsa04810__8 79 3.77138929158136e-23 DOWN -9.9102409901524 1.11072734778705e-22 Regulation of actin cytoskeleton: ARPC5 ACTB hsa04810__8 82 3.77138929158136e-23 DOWN -9.9102409901524 1.11072734778705e-22 Regulation of actin cytoskeleton: ARPC5 ACTB* hsa04530__11 36 14 3.97292301595405e-23 DOWN -9.90503837376339 1.16825075852546e-22 Tight junction: TJP1 CTNNB1 CTNNA1 hsa05164__47 4.31136429258519e-23 UP 9.89686283372352 1.26578961027618e-22 Influenza A: CIITA hsa04610__46 4.40851980176054e-23 UP 9.89463314098537 1.29229465015726e-22 Complement and coagulation cascades: C2 hsa04611__92 5.34662689652592e-23 DOWN -9.87530913725476 1.56484609635081e-22 Platelet activation: RHOA* hsa03320__59 5.75788405227046e-23 UP 9.8678768281276 1.68259162273969e-22 PPAR signaling pathway: NR1H3 hsa04727__49 6.2004354954237e-23 UP 9.86044451900044 1.80910221986043e-22 GABAergic synapse: GABRR3 hsa04520__44 49 6.33965091537994e-23 DOWN -9.8582148262623 1.84685334418588e-22 Adherens junction: ACTB VCL hsa04066__89 6.38674024249693e-23 UP 9.85747159534958 1.85769116341358e-22 HIF-1 signaling pathway: CDKN1A hsa05220__21 6.43417581755924e-23 UP 9.85672836443686 1.8685960372788e-22 Chronic myeloid leukemia: NFKBIA hsa04014__61 6.57858531690112e-23 UP 9.85449867169872 1.90464742842176e-22 Ras signaling pathway: RAP1A hsa05162__20 6.57858531690112e-23 UP 9.85449867169872 1.90464742842176e-22 Measles: NFKB1 hsa04115__37 6.72620284743176e-23 UP 9.85226897896057 1.94439002312681e-22 p53 signaling pathway: FAS hsa05164__70 7.40470111179448e-23 UP 9.84260697709526 2.13396217623648e-22 Influenza A: RNASEL hsa05168__83 7.40470111179448e-23 UP 9.84260697709526 2.13396217623648e-22 Herpes simplex infection: RNASEL hsa05152__126 8.27211154126558e-23 UP 9.83145851340453 2.38029059510536e-22 Tuberculosis: NOS2 hsa04062__8 41 8.84007672643762e-23 UP 9.82476943519008 2.53983244173949e-22 Chemokine signaling pathway: PXN PTK2B hsa05152__76 9.104738594396e-23 UP 9.82179651153922 2.61187844562902e-22 Tuberculosis: TNF* hsa04210__71 9.30836859205755e-23 UP 9.81956681880107 2.66622325982868e-22 Apoptosis: GADD45G hsa04662__35 9.65781700868795e-23 UP 9.8158506642375 2.76210626473739e-22 B cell receptor signaling pathway: CD79B hsa04922__78 1.05503702910859e-22 DOWN -9.80693189328491 3.01278811199856e-22 Glucagon signaling pathway: ACACA hsa05231__38 1.07859782496613e-22 DOWN -9.80470220054676 3.0753950123086e-22 Choline metabolism in cancer: RPS6KB1 hsa04068__46 1.10267934574935e-22 UP 9.80247250780861 3.13929468282277e-22 FoxO signaling pathway: PLK4 hsa04930__9 1.11898974738719e-22 DOWN -9.80098604598318 3.18091034090852e-22 Type II diabetes mellitus: C00238 hsa05213__31 1.32519644857735e-22 UP 9.78389173499072 3.76139596204962e-22 Endometrial cancer: MYC hsa04912__19 1.40538345156593e-22 UP 9.77794588768899 3.98297964629318e-22 GnRH signaling pathway: MAPK7 hsa03320__42 1.42616936416521e-22 DOWN -9.77645942586356 4.03580155913619e-22 PPAR signaling pathway: ACOX1 hsa04068__52 1.43667614465173e-22 DOWN -9.77571619495084 4.04118933503083e-22 FoxO signaling pathway: CAT hsa04723__9 1.43667614465173e-22 DOWN -9.77571619495084 4.04118933503083e-22 Retrograde endocannabinoid signaling: PRKCA hsa04725__20 1.43667614465173e-22 DOWN -9.77571619495084 4.04118933503083e-22 Cholinergic synapse: PRKCA hsa04726__18 1.43667614465173e-22 DOWN -9.77571619495084 4.04118933503083e-22 Serotonergic synapse: PRKCA hsa04510__20 69 1.45792009823802e-22 UP 9.77422973312541 4.09481594109003e-22 Focal adhesion: VASP ACTB hsa04390__5 1.50134519178204e-22 DOWN -9.77125680947455 4.21048897814695e-22 Hippo signaling pathway: SAV1 hsa04014__24 1.5235353991492e-22 UP 9.76977034764912 4.26635322652957e-22 Ras signaling pathway: PLD1 hsa04064__130 1.58044130933545e-22 UP 9.76605419308554 4.41912086345433e-22 NF-kappa B signaling pathway: TNF* hsa04726__64 1.77705595146748e-22 UP 9.75416249848208 4.96149796851023e-22 Serotonergic synapse: CASP3 hsa04918__14 1.88425494672343e-22 DOWN -9.74821665118036 5.25298968085064e-22 Thyroid hormone synthesis: DUOX2 hsa03320__55 1.99785067510901e-22 UP 9.74227080387863 5.56142432374789e-22 PPAR signaling pathway: SCD hsa05205__284 2.08747156980899e-22 DOWN -9.73781141840234 5.8023063308744e-22 Proteoglycans in cancer: PRKCA* hsa04015__92 2.39825706849809e-22 UP 9.72369003106074 6.65631467017416e-22 Rap1 signaling pathway: C00076* hsa05166__136 139 2.7954540223629e-22 UP 9.7080821818937 7.74728334516206e-22 HTLV-I infection: TP53 TBPL2 hsa05212__12 2.92041348545572e-22 DOWN -9.70362279641741 8.08167443176922e-22 Pancreatic cancer: CASP9 hsa03320__26 3.14107758911724e-22 DOWN -9.69619048729025 8.67953645581072e-22 PPAR signaling pathway: CPT2 hsa05211__22 3.71319252722923e-22 UP 9.67909617629779 1.02453579422375e-21 Renal cell carcinoma: TGFA hsa05161__194 3.85060002446163e-22 UP 9.67538002173421 1.060891121109e-21 Hepatitis B: TNF* hsa05223__37 4.02214480417054e-22 UP 9.67092063625792 1.10653149151339e-21 Non-small cell lung cancer: CCND1* hsa05010__12 4.05146184070752e-22 UP 9.6701774053452 1.11296736822945e-21 Alzheimer's disease: CASP3 hsa05100__55 5.65511416515638e-22 DOWN -9.63598878336027 1.55123496588742e-21 Bacterial invasion of epithelial cells: ACTB* hsa05222__34 5.69618736680157e-22 UP 9.63524555244756 1.56022391577553e-21 Small cell lung cancer: CCND1 hsa04340__52 6.21270048317767e-22 UP 9.62632678149497 1.69922331992589e-21 Hedgehog signaling pathway: BCL2* hsa04151__51 6.77551594802802e-22 UP 9.61740801054238 1.8504643119687e-21 PI3K-Akt signaling pathway: NOS3 hsa05205__352 7.45736551731843e-22 UP 9.60700277776436 2.03372856415694e-21 Proteoglycans in cancer: ITGA5* hsa04066__43 7.60510336016033e-22 UP 9.60551631593893 2.07101292952772e-21 HIF-1 signaling pathway: PFKL hsa04015__14 7.71562639746442e-22 UP 9.60402985411349 2.09806975410067e-21 Rap1 signaling pathway: MAPK14 hsa03320__63 7.99893574782156e-22 DOWN -9.60031369954991 2.17196535695906e-21 PPAR signaling pathway: DBI hsa04660__26 8.97651113614216e-22 UP 9.58842200494646 2.43389097039121e-21 T cell receptor signaling pathway: GRB2 hsa04014__79 9.0413913139683e-22 DOWN -9.58767877403375 2.44795018428623e-21 Ras signaling pathway: RAC1** hsa05152__78 9.37281757857866e-22 UP 9.58396261947017 2.53403226333084e-21 Tuberculosis: IL1A hsa04062__42 9.44053119991477e-22 UP 9.58321938855745 2.54867214434481e-21 Chemokine signaling pathway: PAK1 hsa05215__13 1.08230682593542e-21 UP 9.56909800121585 2.91772528828215e-21 Prostate cancer: BCL2 hsa04151__73 1.32331478781242e-21 UP 9.54828753565981 3.5623330749277e-21 PI3K-Akt signaling pathway: MAPK1 hsa04914__29 1.46297413790481e-21 UP 9.53788230288179 3.93265866255099e-21 Progesterone-mediated oocyte maturation: CDK2 hsa04380__16 1.52726873971616e-21 UP 9.53342291740549 4.09377740645744e-21 Osteoclast differentiation: NFKB1 hsa05164__36 1.52726873971616e-21 UP 9.53342291740549 4.09377740645744e-21 Influenza A: IL33 hsa04912__26 1.53824525666348e-21 UP 9.53267968649278 4.11732597901807e-21 GnRH signaling pathway: PLD1 hsa05152__9 1.60576256923489e-21 DOWN -9.52822030101648 4.2919315328483e-21 Tuberculosis: TCIRG1 hsa04066__54 1.98990275731387e-21 UP 9.50592337363501 5.31111829686471e-21 HIF-1 signaling pathway: SERPINE1 hsa04660__43 2.42985057609392e-21 UP 9.48511290807897 6.47615493968862e-21 T cell receptor signaling pathway: RHOA hsa04020__18 3.07304174870959e-21 UP 9.46058628795935 8.15571390653295e-21 Calcium signaling pathway: C00002 hsa04020__17 3.07304174870959e-21 UP 9.46058628795935 8.15571390653295e-21 Calcium signaling pathway: C00004 hsa04020__15 3.07304174870959e-21 UP 9.46058628795935 8.15571390653295e-21 Calcium signaling pathway: C13051 hsa05212__8 3.16173164465008e-21 UP 9.45761336430848 8.37925777192878e-21 Pancreatic cancer: NFKB1 hsa04115__49 3.29941455970155e-21 UP 9.45315397883219 8.73183092630876e-21 p53 signaling pathway: MDM2* hsa04064__128 3.9120009573252e-21 UP 9.43531643692701 1.03384666649987e-20 NF-kappa B signaling pathway: IL1B* hsa04914__11 4.28948002433656e-21 UP 9.4256544350617 1.13201305698432e-20 Progesterone-mediated oocyte maturation: CDK1 hsa04664__47 4.83792647434109e-21 UP 9.41301950954553 1.27495986609915e-20 Fc epsilon RI signaling pathway: MAPK8 hsa05164__41 42 5.15579569872262e-21 UP 9.40633043133109 1.35682634704479e-20 Influenza A: STAT1 IRF9 hsa04611__34 5.22919117000423e-21 UP 9.40484396950566 1.37421681236894e-20 Platelet activation: C02198* hsa04261__23 5.53325011998405e-21 DOWN -9.39889812220393 1.45209175634777e-20 Adrenergic signaling in cardiomyocytes: SLC9A1 hsa05321__55 5.61195751154344e-21 UP 9.3974116603785 1.47069290992889e-20 Inflammatory bowel disease (IBD): IL4* hsa05321__94 6.28279331887007e-21 UP 9.38551996577505 1.64420176130318e-20 Inflammatory bowel disease (IBD): IL22 hsa04390__80 7.81612984113458e-21 UP 9.36247980748086 2.04262975959553e-20 Hippo signaling pathway: BIRC2 hsa04024__60 8.26854927942615e-21 UP 9.35653396017914 2.15486880666321e-20 cAMP signaling pathway: PDE3A hsa04922__17 8.26854927942615e-21 DOWN -9.35653396017914 2.15486880666321e-20 Glucagon signaling pathway: PKM hsa04115__31 8.32689225742217e-21 DOWN -9.35579072926642 2.16706794344824e-20 p53 signaling pathway: ADGRB1 hsa04930__7 8.80852946147413e-21 DOWN -9.34984488196469 2.2892429955892e-20 Type II diabetes mellitus: C00002 hsa04210__57 1.13398561766788e-20 UP 9.32308856910692 2.9430372591132e-20 Apoptosis: BAK1 hsa05152__68 1.19934595600691e-20 UP 9.3171427218052 3.10837386391308e-20 Tuberculosis: CD74 hsa05215__25 1.23340937164142e-20 DOWN -9.31416979815433 3.19225373183778e-20 Prostate cancer: FOXO1 hsa04530__11 13 1.36033863912726e-20 DOWN -9.30376456537631 3.51592338778559e-20 Tight junction: TJP1 EPB41 hsa05016__12 1.57532262271699e-20 DOWN -9.28815671620928 4.06597693418301e-20 Huntington's disease: REST hsa04020__16 1.60865968462873e-20 DOWN -9.28592702347113 4.14632585379613e-20 Calcium signaling pathway: C06124 hsa03320__62 1.82382361251544e-20 UP 9.27254886704225 4.69447201084455e-20 PPAR signaling pathway: UBC hsa03320__31 1.96910646997268e-20 UP 9.26437332700238 5.06149255414318e-20 PPAR signaling pathway: CD36 hsa05215__8 2.03886197602157e-20 UP 9.2606571724388 5.23363613790237e-20 Prostate cancer: NFKBIA hsa04930__15 2.2474416487445e-20 DOWN -9.25025193966078 5.7611771596056e-20 Type II diabetes mellitus: C00031* hsa04064__94 2.40921004127243e-20 UP 9.24281963053362 6.16744641355709e-20 NF-kappa B signaling pathway: BCL2L1* hsa05216__11 2.58248125062303e-20 UP 9.23538732140646 6.60201669376963e-20 Thyroid cancer: MYC hsa04024__91 2.69229903626626e-20 UP 9.23092793593016 6.8734101754678e-20 cAMP signaling pathway: GRIA1 hsa04012__56 2.82626559565483e-20 UP 9.22572531954116 7.20563508037371e-20 ErbB signaling pathway: JUN hsa05200__49 2.84593406232962e-20 DOWN -9.22498208862844 7.24594864921051e-20 Pathways in cancer: CASP9 hsa04976__59 2.94632454526696e-20 UP 9.22126593406486 7.49139894527283e-20 Bile secretion: ABCB4 hsa04152__35 3.47908963898157e-20 DOWN -9.20342839215968 8.83406679952211e-20 AMPK signaling pathway: PFKFB1 hsa04010__57 3.78013133685806e-20 UP 9.19450962120709 9.58551522531214e-20 MAPK signaling pathway: NLK hsa04010__64 3.9130374316567e-20 UP 9.19079346664351 9.90916082760504e-20 MAPK signaling pathway: DDIT3 hsa05160__54 4.19286071190296e-20 UP 9.18336115751636 1.0603479512336e-19 Hepatitis C: IRF1 hsa04973__5 4.22190808155627e-20 UP 9.18261792660364 1.06482755506634e-19 Carbohydrate digestion and absorption: SLC2A5 hsa05220__6 4.22190808155627e-20 UP 9.18261792660364 1.06482755506634e-19 Chronic myeloid leukemia: TP53 hsa05150__66 4.55485796710082e-20 UP 9.17444238656376 1.14726248259818e-19 Staphylococcus aureus infection: IL10 hsa04666__41 4.78011448664888e-20 UP 9.16923977017476 1.20238756632038e-19 Fc gamma R-mediated phagocytosis: MARCKS hsa04213__60 4.94771962056041e-20 DOWN -9.16552361561117 1.24288304372099e-19 Longevity regulating pathway - multiple species: CAT hsa04340__15 5.41116727610874e-20 DOWN -9.15586161374587 1.35748775858589e-19 Hedgehog signaling pathway: HHIP hsa04360__3 5.63929438276001e-20 UP 9.15140222826957 1.41283121936081e-19 Axon guidance: GNAI1 hsa04210__84 5.67822900436141e-20 UP 9.15065899735686 1.41880216744615e-19 Apoptosis: FAS** hsa05223__8 5.67822900436141e-20 DOWN -9.15065899735686 1.41880216744615e-19 Non-small cell lung cancer: CASP9 hsa04360__114 5.79663417443913e-20 DOWN -9.14842930461871 1.44646422493641e-19 Axon guidance: RAF1 hsa04066__88 5.91747929580988e-20 UP 9.14619961188057 1.47466095448631e-19 HIF-1 signaling pathway: BCL2 hsa05150__14 6.33849159112999e-20 UP 9.13876730275341 1.57748684764679e-19 Staphylococcus aureus infection: FPR1 hsa05164__34 7.1724649380069e-20 UP 9.12538914632452 1.78268010826918e-19 Influenza A: IL1B hsa05162__44 7.37201738049086e-20 UP 9.12241622267366 1.82985741848644e-19 Measles: PRKCQ hsa04064__116 7.94952265637905e-20 UP 9.11424068263379 1.97060066904172e-19 NF-kappa B signaling pathway: GADD45B hsa04066__29 8.00418887790595e-20 UP 9.11349745172107 1.98153766819305e-19 HIF-1 signaling pathway: LDHA hsa05160__70 9.49832794589251e-20 UP 9.09491667890318 2.34833660662264e-19 Hepatitis C: CDKN1A hsa05205__233 234 1.12675306280665e-19 UP 9.07633590608528 2.78208804863822e-19 Proteoglycans in cancer: ITGA2 C00925 hsa04350__34 1.23966883997924e-19 UP 9.06593067330726 3.05687368808528e-19 TGF-beta signaling pathway: ROCK1 hsa04972__21 1.33617116658397e-19 DOWN -9.05775513326738 3.2905185085338e-19 Pancreatic secretion: KCNQ1 hsa04933__12 1.37307315237915e-19 UP 9.05478220961652 3.37696917973876e-19 AGE-RAGE signaling pathway in diabetic complications: EGR1 hsa04380__68 1.46979248623364e-19 UP 9.04734990048936 3.61011775376863e-19 Osteoclast differentiation: TGFBR1 hsa04370__23 1.47982336747109e-19 UP 9.04660666957665 3.63001058417517e-19 VEGF signaling pathway: PTK2 hsa04726__41 1.51029200512791e-19 DOWN -9.0443769768385 3.69510244483768e-19 Serotonergic synapse: HTR3C hsa04742__57 1.51029200512791e-19 DOWN -9.0443769768385 3.69510244483768e-19 Taste transduction: HTR3C hsa04621__43 1.6838739118927e-19 UP 9.03248528223505 4.11443313452064e-19 NOD-like receptor signaling pathway: MAPK1 hsa04670__45 1.70690639523801e-19 UP 9.03099882040962 4.16529495669119e-19 Leukocyte transendothelial migration: PXN hsa04722__38 1.8021907969195e-19 UP 9.02505297310789 4.39210960753793e-19 Neurotrophin signaling pathway: ATF4 hsa04012__65 1.95505465256325e-19 UP 9.0161342021553 4.75848146653671e-19 ErbB signaling pathway: MYC hsa04270__28 2.06401106131111e-19 UP 9.01018835485358 5.01717565873683e-19 Vascular smooth muscle contraction: KCNMB2 hsa04913__45 2.12071783098193e-19 DOWN -9.00721543120271 5.14835762844321e-19 Ovarian steroidogenesis: ACOT2 hsa03320__44 2.17896352908626e-19 DOWN -9.00424250755185 5.2829322208427e-19 PPAR signaling pathway: FABP1 hsa04713__61 2.23878939085048e-19 DOWN -9.00126958390099 5.42098616676295e-19 Circadian entrainment: FOS hsa04540__12 2.33158388273623e-19 DOWN -8.99681019842469 5.63841198926818e-19 Gap junction: C00025 hsa04912__15 2.58052580694255e-19 UP 8.98566173473395 6.23240101702449e-19 GnRH signaling pathway: CAMK2A hsa04920__43 2.59802576511667e-19 UP 8.98491850382124 6.26661156951761e-19 Adipocytokine signaling pathway: C00162 hsa04933__27 2.61564297191698e-19 UP 8.98417527290852 6.30101685157949e-19 AGE-RAGE signaling pathway in diabetic complications: TNF hsa04152__87 2.66920586705553e-19 UP 8.98194558017037 6.42181539589928e-19 AMPK signaling pathway: CD36 hsa04916__10 3.0141086029137e-19 UP 8.96856742374149 7.24234023641285e-19 Melanogenesis: CAMK2A hsa04020__7 3.18119728341835e-19 UP 8.96262157643976 7.63406091384812e-19 Calcium signaling pathway: ADCY1 hsa04724__66 3.61559756723788e-19 DOWN -8.94850018909816 8.66544365923465e-19 Glutamatergic synapse: PLA2G4B hsa04912__33 3.86725960702132e-19 UP 8.941067879971 9.25679083005485e-19 GnRH signaling pathway: ELK1 hsa04510__24 69 3.89335806724574e-19 UP 8.94032464905829 9.30740433632918e-19 Focal adhesion: ZYX ACTB hsa04610__17 3.99950327105109e-19 DOWN -8.93735172540743 9.54900463317026e-19 Complement and coagulation cascades: PLG hsa04012__31 4.69912119990966e-19 UP 8.91951418350225 1.12051379881094e-18 ErbB signaling pathway: BAD hsa04611__25 5.09296544373931e-19 UP 8.91059541254966 1.21288746118963e-18 Platelet activation: ORAI1 hsa04919__84 5.1964160527541e-19 UP 8.90836571981151 1.2359576915348e-18 Thyroid hormone signaling pathway: TP53* hsa04261__4 5.51938478420022e-19 DOWN -8.90167664159707 1.31111555113934e-18 Adrenergic signaling in cardiomyocytes: SLC8A1 hsa04024__25 5.74563245319867e-19 DOWN -8.89721725612077 1.36141782844392e-18 cAMP signaling pathway: CFTR hsa04933__61 5.74563245319867e-19 UP 8.89721725612077 1.36141782844392e-18 AGE-RAGE signaling pathway in diabetic complications: MMP2 hsa04933__25 6.22596355531397e-19 UP 8.88829848516818 1.47337349123866e-18 AGE-RAGE signaling pathway in diabetic complications: IL1A hsa05210__16 6.43761703258868e-19 UP 8.88458233060461 1.52154495650744e-18 Colorectal cancer: MAPK8 hsa04210__119 6.79113729946593e-19 UP 8.87863648330288 1.60308379217292e-18 Apoptosis: BCL2* hsa05134__72 6.97502081544718e-19 UP 8.87566355965201 1.64442460630179e-18 Legionellosis: IL12A hsa04151__110 7.35766691345101e-19 UP 8.86971771235029 1.73246317423239e-18 PI3K-Akt signaling pathway: BCL2** hsa04610__45 7.65818983877787e-19 UP 8.865258326874 1.80096854906929e-18 Complement and coagulation cascades: C4A hsa04068__60 8.52014694409128e-19 DOWN -8.85336663227054 2.00116951349344e-18 FoxO signaling pathway: RAG1 hsa04650__119 9.1676397837909e-19 UP 8.84519109223067 2.15056119272698e-18 Natural killer cell mediated cytotoxicity: KLRC4-KLRK1 hsa04261__20 9.29048054401469e-19 DOWN -8.84370463040524 2.17665996785581e-18 Adrenergic signaling in cardiomyocytes: ATP1B4 hsa04010__87 9.7983116030629e-19 UP 8.83775878310351 2.2927805108537e-18 MAPK signaling pathway: STK3 hsa04022__59 1.01295280299587e-18 UP 8.83404262853993 2.36733621496174e-18 cGMP-PKG signaling pathway: NPPB hsa05168__138 1.08254849436872e-18 DOWN -8.82661031941277 2.52684300735257e-18 Herpes simplex infection: CHUK hsa04914__30 1.12651927681661e-18 UP 8.82215093393648 2.62621553491118e-18 Progesterone-mediated oocyte maturation: CDK1* hsa04923__31 1.21185822675947e-18 UP 8.81397539389661 2.82166246354527e-18 Regulation of lipolysis in adipocytes: PRKACA* hsa05205__17 1.29492902825708e-18 UP 8.80654308476945 3.0113510446721e-18 Proteoglycans in cancer: AKT3 hsa04917__56 1.46855275997987e-18 DOWN -8.79242169742785 3.41089077379751e-18 Prolactin signaling pathway: LHCGR hsa04664__25 1.49799259690454e-18 UP 8.7901920046897 3.47497295010325e-18 Fc epsilon RI signaling pathway: MAPK14 hsa04932__138 1.55863166195771e-18 UP 8.78573261921341 3.61118235859252e-18 Non-alcoholic fatty liver disease (NAFLD): CEBPA hsa04621__4 7 8 1.56897119078403e-18 UP 8.78498938830069 3.63066116685123e-18 NOD-like receptor signaling pathway: IKBKG CHUK IKBKB hsa04666__38 1.7554714940503e-18 DOWN -8.77235446278452 4.0572336252405e-18 Fc gamma R-mediated phagocytosis: CFL1 hsa05200__194 1.8629025162302e-18 UP 8.76566538457008 4.30023811793186e-18 Pathways in cancer: BCL2 hsa04151__33 2.00305525137043e-18 UP 8.7574898445302 4.61808689242337e-18 PI3K-Akt signaling pathway: TP53 hsa04115__30 2.09761236416033e-18 UP 8.75228722814119 4.83016376502116e-18 p53 signaling pathway: SERPINE1 hsa05133__94 2.65806190945634e-18 UP 8.72553091528343 6.11321704757462e-18 Pertussis: IL12A hsa05166__34 35 36 2.83838128917923e-18 UP 8.71809860615627 6.51994919604862e-18 HTLV-I infection: MYC TRRAP KAT5 hsa05220__15 2.91390526309694e-18 UP 8.7151256825054 6.68526006026757e-18 Chronic myeloid leukemia: MYC hsa04621__42 3.32207646774258e-18 UP 8.70026106425109 7.61241668644915e-18 NOD-like receptor signaling pathway: MAPK8 hsa04742__4 3.41024114668403e-18 DOWN -8.69728814060023 7.79542957982883e-18 Taste transduction: TRPM5 hsa04919__39 3.41024114668403e-18 DOWN -8.69728814060023 7.79542957982883e-18 Thyroid hormone signaling pathway: ESR1 hsa04530__1 5 3.43264083081748e-18 DOWN -8.69654490968751 7.83709856756505e-18 Tight junction: IGSF5 IGSF5 hsa05120__52 3.64088671707308e-18 DOWN -8.68985583147307 8.30245890944213e-18 Epithelial cell signaling in Helicobacter pylori infection: LYN hsa04071__66 3.7619179487422e-18 UP 8.68613967690949 8.56805312204435e-18 Sphingolipid signaling pathway: C01245 hsa04062__40 3.78659658212795e-18 DOWN -8.68539644599677 8.61381958573658e-18 Chemokine signaling pathway: PRKACA hsa04621__6 4.01601986805427e-18 UP 8.67870736778233 9.11364895178015e-18 NOD-like receptor signaling pathway: NFKB1 hsa05168__9 4.01601986805427e-18 UP 8.67870736778233 9.11364895178015e-18 Herpes simplex infection: NFKB1 hsa04340__40 4.09550247172965e-18 UP 8.67647767504418 9.28280958308806e-18 Hedgehog signaling pathway: SUFU hsa05131__12 4.17653763854635e-18 UP 8.67424798230603 9.45507737690192e-18 Shigellosis: ARPC5 hsa05213__13 4.51681084715211e-18 DOWN -8.66532921135345 1.02131017831514e-17 Endometrial cancer: CASP9 hsa04066__45 4.75871780499854e-18 UP 8.65938336405172 1.07471523504715e-17 HIF-1 signaling pathway: ALDOA hsa04360__89 4.82116610104085e-18 DOWN -8.65789690222629 1.08751153707752e-17 Axon guidance: CAMK2A hsa04066__44 4.91635835479399e-18 UP 8.65566720948814 1.10765435835227e-17 HIF-1 signaling pathway: GAPDH hsa04390__74 4.98084818268749e-18 UP 8.65418074766271 1.12083996829578e-17 Hippo signaling pathway: AXIN1 hsa05205__34 5.11234328268169e-18 UP 8.65120782401185 1.14905418997116e-17 Proteoglycans in cancer: SLC9A1 hsa05210__40 5.31603651668001e-18 DOWN -8.64674843853555 1.19340891455696e-17 Colorectal cancer: CASP9 hsa05205__144 5.82299830540039e-18 DOWN -8.63634320575753 1.30565797325147e-17 Proteoglycans in cancer: NUDT16L1 hsa04010__14 6.21404585484083e-18 UP 8.62891089663037 1.39167963781239e-17 MAPK signaling pathway: MAPT hsa05215__24 6.89429146768119e-18 UP 8.61701920202692 1.54218734140154e-17 Prostate cancer: CDKN1A hsa04340__46 7.45222964617031e-18 DOWN -8.60810043107433 1.66501064270559e-17 Hedgehog signaling pathway: PRKACA hsa04910__9 9.52979838764555e-18 UP 8.57985765639113 2.12666165919074e-17 Insulin signaling pathway: ELK1 hsa04722__73 77 1.04989641421384e-17 DOWN -8.56870919270039 2.34016057213263e-17 Neurotrophin signaling pathway: NGFRAP1 YWHAE hsa04010__65 1.54477225934631e-17 UP 8.52411533793745 3.43913160581956e-17 MAPK signaling pathway: ELK4 hsa05152__13 1.55472126231153e-17 DOWN -8.52337210702473 3.45718491347143e-17 Tuberculosis: LAMP1 hsa04750__59 1.62615687363074e-17 UP 8.51816949063572 3.61175977015621e-17 Inflammatory mediator regulation of TRP channels: TRPV2 hsa04630__33 2.07429651405523e-17 DOWN -8.48992671595252 4.60165661146374e-17 Jak-STAT signaling pathway: RAF1 hsa04530__5 10 2.12803194873292e-17 DOWN -8.48695379230166 4.71529720715702e-17 Tight junction: IGSF5 MAGI1 hsa04022__60 2.2112202291786e-17 UP 8.48249440682536 4.89385490062024e-17 cGMP-PKG signaling pathway: TRPC6* hsa04919__49 2.37211017016402e-17 DOWN -8.47431886678549 5.24375883498612e-17 Thyroid hormone signaling pathway: ACTB hsa04066__47 2.76445531236577e-17 UP 8.45648132488031 6.1038913418746e-17 HIF-1 signaling pathway: PGK1 hsa04917__38 2.83579122733429e-17 DOWN -8.45350840122944 6.25405131004828e-17 Prolactin signaling pathway: IRF1 hsa04211__62 2.85390710620222e-17 UP 8.45276517031673 6.2866253840023e-17 Longevity regulating pathway - mammal: EHMT2 hsa04360__4 2.94621320623841e-17 UP 8.44904901575315 6.48235903339809e-17 Axon guidance: GNAI1* hsa04151__37 3.82296622603855e-17 DOWN -8.4185765483318 8.40158308622974e-17 PI3K-Akt signaling pathway: G6PC hsa05133__96 3.8963960904607e-17 UP 8.41634685559366 8.55295356772856e-17 Pertussis: IL1B hsa04152__56 4.25788472093116e-17 UP 8.40594162281563 9.33554888054801e-17 AMPK signaling pathway: FASN hsa04933__58 4.74153446904757e-17 UP 8.39330669729947 1.03838499619352e-16 AGE-RAGE signaling pathway in diabetic complications: CCL2 hsa05321__122 4.95608488021791e-17 DOWN -8.38810408091046 1.08410750755873e-16 Inflammatory bowel disease (IBD): IL4** hsa05132__41 5.11517007961137e-17 DOWN -8.38438792634688 1.11630715210102e-16 Salmonella infection: ACTB* hsa05200__191 5.11517007961137e-17 UP 8.38438792634688 1.11630715210102e-16 Pathways in cancer: CCND1* hsa04920__5 5.44860103153368e-17 UP 8.37695561721972 1.18769389074847e-16 Adipocytokine signaling pathway: NFKBIA hsa04520__10 5.65885547484607e-17 DOWN -8.37249623174342 1.23067007375414e-16 Adherens junction: NLK hsa04530__14 20 43 5.65885547484607e-17 DOWN -8.37249623174342 1.23067007375414e-16 Tight junction: CTNNA1 ACTB ACTN4 hsa04919__103 5.98928882869374e-17 DOWN -8.36580715352898 1.3010258623255e-16 Thyroid hormone signaling pathway: CCND1 hsa04024__24 6.14224523625772e-17 UP 8.36283422987812 1.33117402525124e-16 cAMP signaling pathway: PLN hsa04360__111 6.14224523625772e-17 DOWN -8.36283422987812 1.33117402525124e-16 Axon guidance: RHOA*** hsa03320__7 6.3388175110498e-17 DOWN -8.35911807531454 1.37219332986896e-16 PPAR signaling pathway: AQP7 hsa04919__88 6.50053147275522e-17 DOWN -8.35614515166368 1.40558097092141e-16 Thyroid hormone signaling pathway: FOXO1 hsa05168__123 6.54159160716794e-17 UP 8.35540192075096 1.41283340573202e-16 Herpes simplex infection: CYCS hsa04621__44 6.75076030240871e-17 UP 8.35168576618738 1.45633508705235e-16 NOD-like receptor signaling pathway: MAPK14 hsa05161__57 7.18908227890121e-17 DOWN -8.34425345706022 1.54911532133662e-16 Hepatitis B: STAT3* hsa05200__215 7.70369279383519e-17 UP 8.33607791702035 1.65810295070061e-16 Pathways in cancer: CSF1R hsa05133__30 7.99952922904071e-17 UP 8.33161853154405 1.71980725644937e-16 Pertussis: NOS2 hsa04530__11 43 8.25459585103635e-17 DOWN -8.32790237698048 1.77261549761112e-16 Tight junction: TJP1 ACTN4 hsa04961__13 9.1259162917774e-17 DOWN -8.31601068237702 1.95748820916093e-16 Endocrine and other factor-regulated calcium reabsorption: ATP2B1 hsa04012__57 9.65526007521303e-17 UP 8.30932160416258 2.06866974701543e-16 ErbB signaling pathway: ABL1 hsa04010__12 1.19426105902942e-16 UP 8.28405175313024 2.55291982925629e-16 MAPK signaling pathway: PLA2G4B hsa04620__46 1.19426105902942e-16 UP 8.28405175313024 2.55291982925629e-16 Toll-like receptor signaling pathway: TNF hsa05200__202 1.26326705227826e-16 UP 8.2773626749158 2.69736226276232e-16 Pathways in cancer: FIGF* hsa05214__27 1.30328729683685e-16 DOWN -8.27364652035222 2.77650434326128e-16 Glioma: MTOR hsa05214__48 1.30328729683685e-16 DOWN -8.27364652035222 2.77650434326128e-16 Glioma: MTOR* hsa05200__205 1.40450731323115e-16 UP 8.26472774939963 2.98875338795168e-16 Pathways in cancer: SLC2A1 hsa04151__36 1.4489349261186e-16 DOWN -8.26101159483605 3.07632624426762e-16 PI3K-Akt signaling pathway: PCK1 hsa05162__93 1.4489349261186e-16 UP 8.26101159483605 3.07632624426762e-16 Measles: TP53 hsa05152__51 1.56129311501293e-16 UP 8.25209282388346 3.31113968748228e-16 Tuberculosis: CASP3 hsa04630__34 1.61060560003227e-16 DOWN -8.24837666931989 3.4118691346794e-16 Jak-STAT signaling pathway: AOX1 hsa05132__48 1.6206507960542e-16 DOWN -8.24763343840717 3.42928248399307e-16 Salmonella infection: KLC3 hsa04920__10 1.68223215379918e-16 DOWN -8.24317405293088 3.55558404610648e-16 Adipocytokine signaling pathway: PCK1 hsa04662__36 1.73530768826803e-16 UP 8.2394578983673 3.66364398455688e-16 B cell receptor signaling pathway: CD79A hsa05221__29 1.74611922186957e-16 DOWN -8.23871466745458 3.68233223108073e-16 Acute myeloid leukemia: RPS6KB1 hsa05014__31 34 1.89286041324281e-16 UP 8.22905266558928 3.98731470457762e-16 Amyotrophic lateral sclerosis (ALS): NEFL PRPH hsa05161__31 1.90463902231513e-16 DOWN -8.22830943467656 4.00763350832042e-16 Hepatitis B: ELK1 hsa05032__38 2.1693713040162e-16 UP 8.21270158550953 4.55956228215486e-16 Morphine addiction: CACNA1A hsa05212__19 2.38035809901569e-16 DOWN -8.20155312181879 4.99742219893908e-16 Pancreatic cancer: MAPK8 hsa05016__48 2.50102679312791e-16 DOWN -8.19560727451706 5.23905166587218e-16 Huntington's disease: HIP1 hsa05016__46 2.50102679312791e-16 DOWN -8.19560727451706 5.23905166587218e-16 Huntington's disease: HTT** hsa05205__45 46 3.10383055257646e-16 UP 8.16959419257201 6.49454076647123e-16 Proteoglycans in cancer: PAK1 FLNA hsa05200__190 3.14230319698015e-16 UP 8.16810773074658 6.56772826154139e-16 Pathways in cancer: MYC* hsa04722__53 3.40408630371262e-16 UP 8.15844572888127 7.10697573852891e-16 Neurotrophin signaling pathway: JUN hsa04012__35 3.48887642748031e-16 UP 8.15547280523041 7.27591432545561e-16 ErbB signaling pathway: CBLC hsa04010__120 3.59779609317179e-16 UP 8.15175665066683 7.49474374619711e-16 MAPK signaling pathway: NFATC1 hsa04620__34 3.61997880543538e-16 UP 8.15101341975412 7.53260263057927e-16 Toll-like receptor signaling pathway: IL1B hsa05200__195 3.68733889213844e-16 UP 8.14878372701597 7.66428072823908e-16 Pathways in cancer: BIRC8 hsa04014__38 3.84935385094749e-16 UP 8.14358111062696 7.99219434909429e-16 Ras signaling pathway: MAPK8 hsa04071__1 4.09303996733128e-16 UP 8.1361488014998 8.47940694444925e-16 Sphingolipid signaling pathway: MAPK1 hsa04261__62 4.09303996733128e-16 UP 8.1361488014998 8.47940694444925e-16 Adrenergic signaling in cardiomyocytes: BCL2 hsa05132__8 4.51491750448186e-16 DOWN -8.12425710689635 9.34309470365794e-16 Salmonella infection: TJP1 hsa04919__27 4.62691280682228e-16 DOWN -8.12128418324548 9.55381226815282e-16 Thyroid hormone signaling pathway: GATA4 hsa05169__117 4.62691280682228e-16 UP 8.12128418324548 9.55381226815282e-16 Epstein-Barr virus infection: CDKN1A hsa05200__226 4.82952953039228e-16 UP 8.11608156685647 9.96123599078714e-16 Pathways in cancer: CDKN1A* hsa04932__31 133 5.62704731846934e-16 DOWN -8.09750079403858 1.15934450782937e-15 Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA hsa05168__39 40 5.98134035001858e-16 DOWN -8.09006848491142 1.23098998003121e-15 Herpes simplex infection: POU2F3 HCFC2 hsa04071__59 60 6.79822673871397e-16 UP 8.07446063574439 1.39757856039864e-15 Sphingolipid signaling pathway: TP53 BCL2 hsa05030__78 7.40290967484311e-16 DOWN -8.06405540296637 1.52022593213445e-15 Cocaine addiction: GRIA2 hsa04530__5 15 8.51331510953194e-16 DOWN -8.04696109197391 1.74634487890945e-15 Tight junction: IGSF5 MPDZ hsa04664__3 4 5 9.7872658062194e-16 UP 8.02986678098144 2.00548227370624e-15 Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A hsa04622__9 35 9.96692566451439e-16 UP 8.02763708824329 2.03785128657481e-15 RIG-I-like receptor signaling pathway: IRF3 PIN1 hsa04920__2 9.96692566451439e-16 DOWN -8.02763708824329 2.03785128657481e-15 Adipocytokine signaling pathway: C00638 hsa04014__97 1.00274660456099e-15 UP 8.02689385733058 2.04800094561968e-15 Ras signaling pathway: PAK4 hsa04726__45 1.0149477384083e-15 UP 8.02540739550515 2.07066970734983e-15 Serotonergic synapse: TRPC1 hsa05215__35 1.11138541468566e-15 DOWN -8.01425893181441 2.2649600804711e-15 Prostate cancer: CASP9 hsa04921__65 1.14548906936175e-15 UP 8.01054277725083 2.33193278584045e-15 Oxytocin signaling pathway: TRPM2 hsa05321__92 1.18062314774823e-15 UP 8.00682662268725 2.40085594655729e-15 Inflammatory bowel disease (IBD): IL17F hsa05210__22 1.31612029351206e-15 UP 7.99344846625837 2.67350273676665e-15 Colorectal cancer: MYC hsa05223__23 1.3240814119859e-15 DOWN -7.99270523534565 2.68676994937528e-15 Non-small cell lung cancer: CASP9* hsa04970__32 1.38950144114256e-15 DOWN -7.98675938804393 2.81647595243459e-15 Salivary secretion: RYR3 hsa05210__23 1.44064609059355e-15 UP 7.98230000256763 2.91699784938069e-15 Colorectal cancer: CCND1 hsa05166__39 1.53927217967759e-15 UP 7.97412446252776 3.11333953241572e-15 HTLV-I infection: RRAS2 hsa04152__64 1.6845539536148e-15 DOWN -7.96297599883702 3.40352352563678e-15 AMPK signaling pathway: ACACB hsa04024__44 67 1.73591959386686e-15 UP 7.95925984427344 3.5035369676432e-15 cAMP signaling pathway: CREB3 CREBBP hsa04742__23 45 1.91083006494695e-15 UP 7.94736814966999 3.85241383265592e-15 Taste transduction: PKD1L3 PKD2L1 hsa04920__9 2.02892811565115e-15 DOWN -7.93993584054283 4.08612639797268e-15 Adipocytokine signaling pathway: G6PC hsa05152__6 2.07813406088257e-15 UP 7.93696291689197 4.18074293404534e-15 Tuberculosis: IL10 hsa04972__23 2.56196144069437e-15 UP 7.91094983494691 5.1485834727965e-15 Pancreatic secretion: KCNMA1 hsa05211__45 2.63957814979111e-15 UP 7.90723368038334 5.29889673446315e-15 Renal cell carcinoma: ETS1 hsa05168__91 92 2.6712691228381e-15 UP 7.9057472185579 5.35679261666254e-15 Herpes simplex infection: STAT1 IRF9 hsa04068__13 2.78516620146636e-15 DOWN -7.90054460216889 5.57924018396087e-15 FoxO signaling pathway: PCK1 hsa04930__26 3.06376575950834e-15 DOWN -7.88865290756544 6.13079431535268e-15 Type II diabetes mellitus: INS* hsa04913__64 3.21318023654355e-15 DOWN -7.88270706026371 6.42294219623972e-15 Ovarian steroidogenesis: PLA2G4B hsa04742__48 3.57609227912472e-15 UP 7.86932890383483 7.14078362643501e-15 Taste transduction: GABBR1 hsa04917__48 4.00295893938975e-15 DOWN -7.85520751649323 7.9846707506511e-15 Prolactin signaling pathway: CCND2 hsa04742__55 4.09865078691418e-15 UP 7.85223459284237 8.16687680658721e-15 Taste transduction: P2RX3 hsa05200__207 4.56015336188826e-15 UP 7.83885643641348 9.07683068536869e-15 Pathways in cancer: CDK4 hsa05020__49 4.61444078990617e-15 UP 7.83736997458805 9.1751685124166e-15 Prion diseases: BAX hsa04068__40 6.89134559517985e-15 UP 7.78683027252338 1.36879898238297e-14 FoxO signaling pathway: CCND1 hsa04010__13 7.18079956403247e-15 UP 7.78162765613437 1.42478589026579e-14 MAPK signaling pathway: STMN1 hsa03320__36 7.39484586846749e-15 DOWN -7.77791150157079 1.46570837414034e-14 PPAR signaling pathway: SLC27A4 hsa04390__59 8.36452289265847e-15 UP 7.76230365240376 1.65615790466863e-14 Hippo signaling pathway: SERPINE1 hsa04666__30 44 8.92133218758746e-15 UP 7.75412811236388 1.76454559794493e-14 Fc gamma R-mediated phagocytosis: C04637 GSN hsa04380__38 9.13272272692146e-15 UP 7.75115518871302 1.80445699304789e-14 Osteoclast differentiation: FOS hsa04024__114 1.05701376117307e-14 DOWN -7.73257441589512 2.08626980802961e-14 cAMP signaling pathway: HHIP hsa05166__74 1.29629875822381e-14 UP 7.70656133395007 2.55587131868051e-14 HTLV-I infection: NFKB1 hsa03460__27 1.53432580672916e-14 UP 7.68500763748131 3.02201068222651e-14 Fanconi anemia pathway: BRCA1 hsa05142__49 1.67381774940304e-14 DOWN -7.67385917379058 3.29330214777833e-14 Chagas disease (American trypanosomiasis): ADCY1 hsa04914__34 1.75324017819715e-14 DOWN -7.66791332648885 3.44596055944815e-14 Progesterone-mediated oocyte maturation: MAPK14 hsa04012__29 1.79433020946878e-14 UP 7.66494040283799 3.52303705704476e-14 ErbB signaling pathway: STAT5A* hsa03320__9 2.15900657920966e-14 DOWN -7.64115701363108 4.23462772686321e-14 PPAR signaling pathway: PCK1 hsa04510__23 4 5 2.28725320384412e-14 UP 7.63372470450392 4.4814898540387e-14 Focal adhesion: TLN1 ITGB1 ITGA11 hsa04360__29 2.38145504916994e-14 UP 7.62852208811491 4.66120212228157e-14 Axon guidance: RASA1 hsa04912__20 2.42298601693789e-14 UP 7.62629239537677 4.73755538587545e-14 GnRH signaling pathway: PLA2G4B hsa04071__68 2.5081965754925e-14 UP 7.62183300990047 4.89906586834761e-14 Sphingolipid signaling pathway: NFKB1 hsa04724__68 3.15656988417991e-14 DOWN -7.59210377339184 6.1590808020499e-14 Glutamatergic synapse: MAPK1 hsa04010__68 3.24840802188754e-14 UP 7.58838761882826 6.33169986838869e-14 MAPK signaling pathway: ATF2 hsa04024__3 3.68470885265104e-14 UP 7.57203653874851 7.17468179702725e-14 cAMP signaling pathway: RYR2 hsa05032__30 3.769949162516e-14 DOWN -7.56906361509765 7.33305846414862e-14 Morphine addiction: ADORA1 hsa05120__53 3.99184015193378e-14 DOWN -7.56163130597049 7.75663665510194e-14 Epithelial cell signaling in Helicobacter pylori infection: GIT1 hsa04211__57 4.0377268210169e-14 DOWN -7.56014484414506 7.82960649813287e-14 Longevity regulating pathway - mammal: ATG5 hsa04914__42 4.0377268210169e-14 DOWN -7.56014484414506 7.82960649813287e-14 Progesterone-mediated oocyte maturation: ARAF hsa04917__68 4.13105453045093e-14 DOWN -7.5571719204942 8.00232109558483e-14 Prolactin signaling pathway: CCND1 hsa04110__46 4.47471277497853e-14 UP 7.54676668771618 8.65909918041675e-14 Cell cycle: RB1 hsa04914__39 6.04959564674413e-14 DOWN -7.50737544934224 1.16946401442718e-13 Progesterone-mediated oocyte maturation: PIK3R5 hsa04310__31 6.89211085237632e-14 DOWN -7.49028113834977 1.33096364764801e-13 Wnt signaling pathway: MMP7 hsa04066__60 7.63099356719633e-14 UP 7.47690298192089 1.47213931342525e-13 HIF-1 signaling pathway: NOS3 hsa04540__16 17 8.88752758797812e-14 UP 7.45683574727756 1.71278608592932e-13 Gap junction: GJA1 GJA1** hsa04918__10 9.29742534579929e-14 DOWN -7.45088989997584 1.78994490007755e-13 Thyroid hormone synthesis: TG hsa05205__451 9.40276916552963e-14 UP 7.44940343815041 1.80837290297136e-13 Proteoglycans in cancer: KDR** hsa05012__71 1.06418540000062e-13 DOWN -7.43305235807066 2.04249679938832e-13 Parkinson's disease: PRKACA* hsa05014__33 34 1.06418540000062e-13 UP 7.43305235807066 2.04249679938832e-13 Amyotrophic lateral sclerosis (ALS): NEFH PRPH hsa04550__9 1.07621500798177e-13 UP 7.43156589624523 2.06347755101811e-13 Signaling pathways regulating pluripotency of stem cells: HNF1A hsa05133__60 1.08227982798542e-13 UP 7.43082266533251 2.0729906185368e-13 Pertussis: C5 hsa05020__48 1.18401114698173e-13 DOWN -7.41893097072906 2.2655366040516e-13 Prion diseases: SOD1 hsa04066__26 1.19737055002727e-13 UP 7.41744450890363 2.2887683250267e-13 HIF-1 signaling pathway: C01245 hsa04261__15 17 1.28788962376358e-13 DOWN -7.40778250703832 2.45929329578431e-13 Adrenergic signaling in cardiomyocytes: ACTC1 MYH6 hsa03320__57 1.33938205002645e-13 DOWN -7.40257989064931 2.55502423553268e-13 PPAR signaling pathway: APOC3 hsa04210__83 1.35446215146329e-13 UP 7.40109342882388 2.58117077342751e-13 Apoptosis: TP53* hsa04014__104 1.47300692198495e-13 UP 7.38994496513314 2.80423506221857e-13 Ras signaling pathway: BRAP* hsa05160__37 1.52298914100659e-13 DOWN -7.38548557965685 2.89645404448521e-13 Hepatitis C: STAT3 hsa03320__38 1.57513179592714e-13 UP 7.38102619418055 2.99259114716592e-13 PPAR signaling pathway: SORBS1 hsa05205__220 1.59281601580988e-13 UP 7.37953973235512 3.02313261990582e-13 Proteoglycans in cancer: FAS hsa03320__46 1.64704740257302e-13 DOWN -7.37508034687883 3.12290824362734e-13 PPAR signaling pathway: APOA2 hsa05200__198 1.86186654570364e-13 UP 7.35872926679908 3.52666052356566e-13 Pathways in cancer: BCL2L1* hsa04931__149 1.9037798555041e-13 DOWN -7.35575634314822 3.60241928347654e-13 Insulin resistance: ACACB* hsa04630__31 1.93582183490804e-13 DOWN -7.35352665041007 3.6593654203141e-13 Jak-STAT signaling pathway: BCL2L1 hsa04915__40 2.15141525945818e-13 DOWN -7.33940526306847 4.06282338946926e-13 Estrogen signaling pathway: CREB3** hsa04810__48 2.77586493866346e-13 DOWN -7.30521664108354 5.23679740938618e-13 Regulation of actin cytoskeleton: IQGAP2 hsa04750__53 2.85363256258424e-13 UP 7.30150048651996 5.3781099148403e-13 Inflammatory mediator regulation of TRP channels: TRPM8 hsa05166__62 63 2.98253357547812e-13 UP 7.29555463921824 5.61541141114569e-13 HTLV-I infection: ANAPC10 CDC20 hsa04664__23 3.0829458970198e-13 UP 7.29109525374194 5.7986539944947e-13 Fc epsilon RI signaling pathway: AKT3 hsa05210__53 3.86372192904281e-13 UP 7.26062278632059 7.25993350467144e-13 Colorectal cancer: CCND1* hsa04152__60 4.68149858672078e-13 UP 7.23460970437554 8.787748096352e-13 AMPK signaling pathway: EEF2 hsa04916__9 4.91788688444866e-13 UP 7.2279206261611 9.22226492602698e-13 Melanogenesis: PRKACA hsa04024__115 5.19429782887805e-13 UP 7.22048831703394 9.73089294163694e-13 cAMP signaling pathway: F2R hsa04810__26 80 5.39680390702698e-13 UP 7.21528570064493 1.01001937662387e-12 Regulation of actin cytoskeleton: PFN3 ACTB hsa05200__80 5.6996064855414e-13 UP 7.20785339151777 1.06562791903804e-12 Pathways in cancer: TP53 hsa04724__52 5.82534383948586e-13 UP 7.20488046786691 1.08805378473101e-12 Glutamatergic synapse: CACNA1A hsa05200__196 6.05196908149926e-13 UP 7.1996778514779 1.12926016922911e-12 Pathways in cancer: TRAF1 hsa04510__26 4 5 6.151723318551e-13 UP 7.19744815873975 1.14673493209894e-12 Focal adhesion: ACTN4 ITGB1 ITGA11 hsa05205__324 6.18533207420482e-13 UP 7.19670492782704 1.15185718210415e-12 Proteoglycans in cancer: KDR* hsa05200__121 122 6.78504611064682e-13 UP 7.18407000231087 1.26103873807175e-12 Pathways in cancer: SMAD2 SMAD4 hsa05212__38 39 6.78504611064682e-13 UP 7.18407000231087 1.26103873807175e-12 Pancreatic cancer: SMAD2 SMAD4 hsa05168__10 7.08666772248051e-13 UP 7.17812415500914 1.31579532119969e-12 Herpes simplex infection: FOS hsa04340__31 7.1252838135186e-13 UP 7.17738092409643 1.3216592582035e-12 Hedgehog signaling pathway: GLI1*** hsa03460__16 49 7.28182438973131e-13 UP 7.17440800044556 1.34936371087822e-12 Fanconi anemia pathway: FANCM C19orf40 hsa04068__14 7.44173949718804e-13 DOWN -7.1714350767947 1.37763827736121e-12 FoxO signaling pathway: G6PC hsa05031__11 7.48225386792402e-13 UP 7.17069184588198 1.38241445603041e-12 Amphetamine addiction: GRIN3A hsa05031__54 7.48225386792402e-13 UP 7.17069184588198 1.38241445603041e-12 Amphetamine addiction: GRIN3A* hsa04024__113 7.52298472431814e-13 DOWN -7.16994861496927 1.38857448889919e-12 cAMP signaling pathway: PTCH1 hsa04931__137 8.11659355384464e-13 UP 7.15954338219125 1.49667117641551e-12 Insulin resistance: MLXIP* hsa04910__26 8.2496534821712e-13 DOWN -7.1573136894531 1.51971557774507e-12 Insulin signaling pathway: RPS6 hsa05205__142 8.94774150823238e-13 UP 7.14616522576236 1.64669993084903e-12 Proteoglycans in cancer: CTNNB1 hsa05161__10 9.39408767490262e-13 UP 7.13947614754792 1.72715173592388e-12 Hepatitis B: CASP3 hsa05215__9 1.04093425557315e-12 UP 7.12535476020632 1.91194082719643e-12 Prostate cancer: CDKN1B hsa04723__67 1.08683499631342e-12 DOWN -7.11940891290459 1.99429976374308e-12 Retrograde endocannabinoid signaling: PRKACA hsa04510__6 4 5 1.13472035718093e-12 UP 7.11346306560287 2.07810872431089e-12 Focal adhesion: FLNA ITGB1 ITGA11 hsa05220__19 41 1.13472035718093e-12 UP 7.11346306560287 2.07810872431089e-12 Chronic myeloid leukemia: SMAD4 SMAD3 hsa04115__15 1.16569372270019e-12 UP 7.10974691103929 2.13275414309022e-12 p53 signaling pathway: TSC2 hsa05200__146 147 1.21044414456355e-12 DOWN -7.10454429465028 2.20817917246107e-12 Pathways in cancer: RARB RXRA hsa05222__14 15 1.21044414456355e-12 DOWN -7.10454429465028 2.20817917246107e-12 Small cell lung cancer: RXRA RARB hsa05223__29 34 1.21044414456355e-12 DOWN -7.10454429465028 2.20817917246107e-12 Non-small cell lung cancer: RARB RXRA hsa05161__125 1.25015965128532e-12 UP 7.10008490917398 2.27841899589246e-12 Hepatitis B: CDKN1A hsa05014__49 1.26367660890104e-12 DOWN -7.09859844734855 2.30082204275683e-12 Amyotrophic lateral sclerosis (ALS): C00001 hsa04724__5 71 1.27733694226371e-12 UP 7.09711198552312 2.32344251162973e-12 Glutamatergic synapse: GRIN3A DLG4 hsa04068__39 1.48449889239648e-12 UP 7.07630151996708 2.69765320968374e-12 FoxO signaling pathway: CCNB3 hsa04066__49 1.49247714841371e-12 UP 7.07555828905436 2.70953097765156e-12 HIF-1 signaling pathway: EPO hsa04912__46 1.6790358022246e-12 UP 7.05920720897461 3.04527825519306e-12 GnRH signaling pathway: JUN hsa03320__27 1.70618622430309e-12 DOWN -7.05697751623647 3.09153704480762e-12 PPAR signaling pathway: CPT1C hsa04360__58 2.10086267053446e-12 UP 7.02799151064055 3.80300670321218e-12 Axon guidance: PLXNC1 hsa05010__51 2.2633474481196e-12 DOWN -7.01758627786253 4.09319524063208e-12 Alzheimer's disease: ATF6 hsa04630__24 2.29973676463221e-12 DOWN -7.01535658512438 4.15500517379223e-12 Jak-STAT signaling pathway: MCL1 hsa04270__46 2.37424520162227e-12 DOWN -7.01089719964809 4.28550118525288e-12 Vascular smooth muscle contraction: ITPR1* hsa04919__11 2.38689135439628e-12 DOWN -7.01015396873537 4.3041927590313e-12 Thyroid hormone signaling pathway: CTNNB1 hsa04912__17 2.46416735593571e-12 UP 7.00569458325908 4.43928136318619e-12 GnRH signaling pathway: MAPK14 hsa04066__59 2.51704234450405e-12 UP 7.00272165960821 4.53019402808727e-12 HIF-1 signaling pathway: NOS2 hsa04666__40 2.53043399496035e-12 UP 7.0019784286955 4.54993825505311e-12 Fc gamma R-mediated phagocytosis: PLA2G6 hsa04662__29 2.54389551466183e-12 UP 7.00123519778278 4.56540560845233e-12 B cell receptor signaling pathway: RAC1 hsa04670__10 2.54389551466183e-12 UP 7.00123519778278 4.56540560845233e-12 Leukocyte transendothelial migration: BCAR1 hsa04750__62 3.4210053322291e-12 UP 6.9596142666707 6.1336536443306e-12 Inflammatory mediator regulation of TRP channels: TRPM8* hsa04916__4 3.5497080120187e-12 UP 6.95441165028169 6.35834256871606e-12 Melanogenesis: TYR hsa04726__71 3.58732533203467e-12 UP 6.95292518845626 6.41960409418394e-12 Serotonergic synapse: CACNA1A hsa04151__105 62 3.74174235360667e-12 DOWN -6.94697934115453 6.68956601562982e-12 PI3K-Akt signaling pathway: CCND1 CDK2 hsa04014__54 3.90267086246e-12 UP 6.9410334938528 6.97064501004025e-12 Ras signaling pathway: RHOA hsa04066__50 5.12704276245648e-12 UP 6.90238548639158 9.14882559416499e-12 HIF-1 signaling pathway: TF hsa05169__83 5.1539433849407e-12 DOWN -6.90164225547887 9.18810210654989e-12 Epstein-Barr virus infection: GSK3B hsa04921__46 5.18098234157601e-12 DOWN -6.90089902456615 9.227550540115e-12 Oxytocin signaling pathway: C00942* hsa04723__7 5.20815655758954e-12 DOWN -6.90015579365343 9.26716493533215e-12 Retrograde endocannabinoid signaling: ITPR1 hsa04725__25 5.54539875585307e-12 UP 6.89123702270085 9.85790374857892e-12 Cholinergic synapse: CACNA1A hsa05164__20 5.57444909005057e-12 UP 6.89049379178813 9.90017943308603e-12 Influenza A: ATF2 hsa04912__43 5.60364857116337e-12 UP 6.88975056087541 9.94263991049667e-12 GnRH signaling pathway: PTK2B hsa05217__5 5.66249797589946e-12 UP 6.88826409904998 1.00375789591652e-11 Basal cell carcinoma: BMP2 hsa05134__73 5.99716030572754e-12 UP 6.88008855901011 1.06207956780981e-11 Legionellosis: CXCL1 hsa04211__50 7.08483041521019e-12 DOWN -6.8563051698032 1.25352131357627e-11 Longevity regulating pathway - mammal: PPARGC1A* hsa05205__189 7.46276853397613e-12 UP 6.84887286067604 1.31914789043661e-11 Proteoglycans in cancer: IL12B hsa04710__23 7.57995340844383e-12 UP 6.8466431679379 1.33860267429191e-11 Circadian rhythm: BHLHE41 hsa04211__39 8.19346471607194e-12 UP 6.83549470424716 1.44558875131448e-11 Longevity regulating pathway - mammal: TP53* hsa05161__69 8.62923320616563e-12 DOWN -6.82806239512 1.52104401448267e-11 Hepatitis B: SMAD4 hsa04724__33 70 69 1.00254189131615e-11 DOWN -6.80650869865124 1.76548848526996e-11 Glutamatergic synapse: ITPR1 HOMER3 HOMER3 hsa05130__28 1.03407743502307e-11 UP 6.80204931317495 1.81931788427749e-11 Pathogenic Escherichia coli infection: ROCK1 hsa04622__45 1.11722934787877e-11 UP 6.79090084948421 1.96377356844173e-11 RIG-I-like receptor signaling pathway: MAPK14 hsa04015__100 101 48 1.12879975259954e-11 UP 6.78941438765878 1.98225676180797e-11 Rap1 signaling pathway: PRKCI PARD6A PARD3 hsa04742__49 1.14048751296745e-11 UP 6.78792792583335 2.00091133227436e-11 Taste transduction: HTR1A hsa04920__26 1.15229379320392e-11 DOWN -6.78644146400792 2.01973884088634e-11 Adipocytokine signaling pathway: NPY hsa04151__109 1.29032966137618e-11 UP 6.77009038392817 2.25958008734934e-11 PI3K-Akt signaling pathway: RXRA hsa04115__58 1.45940329759231e-11 UP 6.75225284202299 2.55327634653253e-11 p53 signaling pathway: CASP3 hsa04727__35 1.46689994706456e-11 DOWN -6.75150961111028 2.56400465165983e-11 GABAergic synapse: PRKACA hsa04540__1 1.575888427657e-11 DOWN -6.74110437833225 2.75194642710734e-11 Gap junction: C00681 hsa04115__1 1.75441869088495e-11 UP 6.72549652916522 3.06086603544366e-11 p53 signaling pathway: SIAH1 hsa04931__47 1.89390888824455e-11 DOWN -6.71434806547449 3.30116400835947e-11 Insulin resistance: AKT2* hsa05222__32 2.05466796681225e-11 UP 6.70245637087103 3.57805478187231e-11 Small cell lung cancer: BIRC8 hsa05160__22 23 2.18393178012291e-11 UP 6.69353759991844 3.79963686560272e-11 Hepatitis C: STAT1 IRF9 hsa04115__55 2.63467032705679e-11 UP 6.66603805614796 4.57959809855663e-11 p53 signaling pathway: SHISA5 hsa04261__72 2.67497202003766e-11 DOWN -6.66380836340981 4.64535344330016e-11 Adrenergic signaling in cardiomyocytes: ATP2B1 hsa04010__78 2.72964751948836e-11 DOWN -6.66083543975895 4.73592584406153e-11 MAPK signaling pathway: MAP3K4 hsa04722__70 2.7995320121069e-11 DOWN -6.65711928519537 4.8526943272591e-11 Neurotrophin signaling pathway: ZNF274 hsa04024__12 3.3234249000409e-11 UP 6.63184943416303 5.75549805269756e-11 cAMP signaling pathway: SLC9A1 hsa04713__60 3.34020363690068e-11 DOWN -6.63110620325032 5.77922894450863e-11 Circadian entrainment: PER1 hsa04024__9 95 3.40815152031511e-11 UP 6.62813327959945 5.8913677154297e-11 cAMP signaling pathway: ATP1B4 FXYD1 hsa04727__13 3.4949908477099e-11 UP 6.62441712503587 6.03592628938134e-11 GABAergic synapse: CACNA1A hsa04662__6 3.54812989728169e-11 UP 6.62218743229773 6.12207169604435e-11 B cell receptor signaling pathway: NFKB1 hsa05200__193 3.56601799396868e-11 UP 6.62144420138501 6.1472915694194e-11 Pathways in cancer: NOS2 hsa04530__20 31 3.69372946257828e-11 DOWN -6.616241584996 6.36161105424802e-11 Tight junction: ACTB MLLT4 hsa05200__204 3.73103330760751e-11 UP 6.61475512317057 6.4199739789327e-11 Pathways in cancer: TGFB1* hsa03320__64 3.82591325538727e-11 DOWN -6.61103896860699 6.57119836094395e-11 PPAR signaling pathway: APOA5 hsa05162__105 3.82591325538727e-11 DOWN -6.61103896860699 6.57119836094395e-11 Measles: GSK3B hsa04014__44 3.86452277360686e-11 UP 6.60955250678156 6.63145049461852e-11 Ras signaling pathway: ETS1 hsa04151__103 3.92315291201411e-11 UP 6.60732281404341 6.7259163518928e-11 PI3K-Akt signaling pathway: BCL2* hsa04152__103 4.35864562937366e-11 UP 6.59171496487638 7.46572027127904e-11 AMPK signaling pathway: ULK1 hsa05215__30 4.98858526901798e-11 UP 6.57164773023305 8.5369323501683e-11 Prostate cancer: TP53 hsa04921__55 6.05838309722255e-11 DOWN -6.54266172463714 1.03582364328309e-10 Oxytocin signaling pathway: PTGS2* hsa04210__69 6.27283567239173e-11 UP 6.53745910824813 1.07151438440219e-10 Apoptosis: PTPN13 hsa05031__8 6.99619507833559e-11 DOWN -6.52110802816838 1.19399187576681e-10 Amphetamine addiction: DRD1 hsa04340__50 7.49852988921999e-11 UP 6.51070279539036 1.27856058637426e-10 Hedgehog signaling pathway: BCL2 hsa04390__94 7.87867644793134e-11 UP 6.5032704862632 1.34216074756691e-10 Hippo signaling pathway: GLI2 hsa05161__195 8.07575297748064e-11 UP 6.49955433169962 1.37448730477229e-10 Hepatitis B: IL6 hsa05200__185 8.19630410763125e-11 DOWN -6.49732463896147 1.39374257178635e-10 Pathways in cancer: HHIP hsa03320__23 8.27764723200687e-11 UP 6.49583817713604 1.40630191220081e-10 PPAR signaling pathway: ACADL hsa04510__42 8.69635125636428e-11 UP 6.48840586800888 1.47610153664937e-10 Focal adhesion: BIRC2 hsa04924__52 9.00169323537504e-11 UP 6.48320325161987 1.52655068495214e-10 Renin secretion: KCNJ2 hsa04530__11 20 16 9.22618713695233e-11 DOWN -6.4794870970563 1.56321060688309e-10 Tight junction: TJP1 ACTB CTTN hsa04921__54 1.03822425014817e-10 DOWN -6.46164955515112 1.75591662108767e-10 Oxytocin signaling pathway: RCAN1 hsa04972__18 1.03822425014817e-10 DOWN -6.46164955515112 1.75591662108767e-10 Pancreatic secretion: PRKCA hsa04911__31 1.04333658772725e-10 UP 6.4609063242384 1.76297612260747e-10 Insulin secretion: CAMK2A hsa05150__35 1.14525670447954e-10 UP 6.4467849368968 1.93345673649331e-10 Staphylococcus aureus infection: FCAR hsa05133__46 1.16224299751498e-10 DOWN -6.44455524415865 1.96037216546737e-10 Pertussis: CFL1 hsa04710__7 1.1794508202898e-10 UP 6.44232555142051 1.98761263795922e-10 Circadian rhythm: PER1 hsa04970__18 1.19690759248668e-10 DOWN -6.44009585868236 2.01522344648968e-10 Salivary secretion: VAMP2 hsa05152__81 1.23862802477005e-10 UP 6.43489324229335 2.08360076861498e-10 Tuberculosis: IFNA1 hsa05200__210 1.28176874188444e-10 UP 6.42969062590434 2.15424281395426e-10 Pathways in cancer: MMP1 hsa05145__8 1.28805037315695e-10 UP 6.42894739499162 2.16286564000171e-10 Toxoplasmosis: NFKB1 hsa04728__60 1.33287208749688e-10 UP 6.42374477860261 2.23613093964878e-10 Dopaminergic synapse: CACNA1A hsa04210__102 1.33939837051318e-10 UP 6.42300154768989 2.24507541319739e-10 Apoptosis: PIDD1 hsa04950__20 1.43411248178454e-10 DOWN -6.41259631491187 2.39955240718891e-10 Maturity onset diabetes of the young: NKX6-1 hsa05212__14 1.43411248178454e-10 DOWN -6.41259631491187 2.39955240718891e-10 Pancreatic cancer: MAPK1 hsa04740__10 1.49114134401222e-10 UP 6.40665046761015 2.49275318985672e-10 Olfactory transduction: ANO2 hsa05217__19 1.61192536241411e-10 DOWN -6.39475877300669 2.69227356086765e-10 Basal cell carcinoma: HHIP hsa04921__77 1.75073062776638e-10 DOWN -6.38212384749053 2.92151229979843e-10 Oxytocin signaling pathway: KCNJ3 hsa05222__40 1.88285499950482e-10 UP 6.37097538379979 3.13920545170325e-10 Small cell lung cancer: TRAF1 hsa04310__36 1.89200160795294e-10 UP 6.37023215288707 3.15165870686486e-10 Wnt signaling pathway: MYC hsa04014__26 2.14565244440169e-10 DOWN -6.35090814915646 3.57101943581114e-10 Ras signaling pathway: PRKCA hsa05217__3 2.27364860944528e-10 UP 6.34198937820387 3.78069534260857e-10 Basal cell carcinoma: GLI1 hsa03320__61 2.60200339675339e-10 DOWN -6.32117891264783 4.32286859637455e-10 PPAR signaling pathway: APOA1 hsa04670__35 2.91995887939586e-10 UP 6.30334137074265 4.84682220352016e-10 Leukocyte transendothelial migration: PTK2 hsa04350__50 2.93399929941699e-10 DOWN -6.30259813982994 4.86582937652649e-10 TGF-beta signaling pathway: AMHR2 hsa04066__56 3.22906021083953e-10 DOWN -6.28773352157562 5.35044456452159e-10 HIF-1 signaling pathway: TEK hsa04360__59 3.35502934138049e-10 UP 6.28178767427389 5.55427324445282e-10 Axon guidance: MAPK1* hsa05215__22 3.37301753440638e-10 DOWN -6.27955798153575 5.57913727742041e-10 Prostate cancer: C16038 hsa04662__24 3.38726380611791e-10 UP 6.28030121244846 5.59777369542265e-10 B cell receptor signaling pathway: FOS hsa04921__56 3.63885168310002e-10 UP 6.26915274875773 6.00826213756145e-10 Oxytocin signaling pathway: JUN hsa04930__10 3.7984657976673e-10 UP 6.26246367054328 6.26630134663464e-10 Type II diabetes mellitus: C00031 hsa05321__74 3.87158041488623e-10 DOWN -6.25949074689242 6.38131543822038e-10 Inflammatory bowel disease (IBD): IL5 hsa05200__183 4.25826134380925e-10 UP 6.2446261286381 7.01250925943696e-10 Pathways in cancer: BMP2 hsa05205__109 4.57276378117836e-10 UP 6.23347766494737 7.52383813032761e-10 Proteoglycans in cancer: SMAD2 hsa04390__88 5.7121901160108e-10 DOWN -6.19854581204972 9.39038077688915e-10 Hippo signaling pathway: ID1 hsa05200__203 5.82105960015124e-10 UP 6.19557288839886 9.56098862647218e-10 Pathways in cancer: TGFA* hsa05133__24 5.95999658967219e-10 UP 6.19185673383528 9.78064069169786e-10 Pertussis: NFKB1 hsa04012__21 7.09364080769615e-10 UP 6.1643571900648 1.1630847362706e-09 ErbB signaling pathway: GSK3B hsa05205__146 7.57529732504515e-10 DOWN -6.15395195728678 1.24097503694506e-09 Proteoglycans in cancer: PTK2 hsa04720__4 15 7.86470058132644e-10 UP 6.14800610998505 1.28726240351153e-09 Long-term potentiation: CREBBP ATF4 hsa04917__37 8.35813301545032e-10 DOWN -6.13834410811975 1.36683480731342e-09 Prolactin signaling pathway: TNFSF11 hsa04630__27 8.84032752474999e-10 DOWN -6.12942533716716 1.44443264513089e-09 Jak-STAT signaling pathway: PIM1 hsa05205__318 9.13402576383392e-10 UP 6.12422272077815 1.49112375414804e-09 Proteoglycans in cancer: HSPB2 hsa04520__18 9.39332335705524e-10 DOWN -6.11976333530185 1.53212279408913e-09 Adherens junction: SNAI2 hsa05220__22 1.07512603530634e-09 UP 6.09820963883309 1.75209177826593e-09 Chronic myeloid leukemia: CDKN1B hsa05205__69 1.08516620527093e-09 UP 6.09672317700766 1.7669214035564e-09 Proteoglycans in cancer: MAPK1* hsa05152__82 1.10039808308556e-09 UP 6.09449348426951 1.79017142694178e-09 Tuberculosis: IL6 hsa04923__66 1.20740518562552e-09 DOWN -6.0796288660152 1.96255566071829e-09 Regulation of lipolysis in adipocytes: LIPE hsa04971__37 1.21301378785314e-09 UP 6.07888563510248 1.96996794068803e-09 Gastric acid secretion: KCNQ1 hsa04152__30 1.24143997632074e-09 DOWN -6.0751694805389 2.01439180959125e-09 AMPK signaling pathway: ACACA hsa04340__20 22 1.31842153531246e-09 UP 6.0655074786736 2.13745820953591e-09 Hedgehog signaling pathway: GLI1 SUFU* hsa04310__22 1.40652748226097e-09 DOWN -6.05510224589558 2.27637090533043e-09 Wnt signaling pathway: ROCK2 hsa05222__39 1.40652827093594e-09 UP 6.05510224589558 2.27637090533043e-09 Small cell lung cancer: BCL2L1 hsa04932__95 1.45942462058159e-09 UP 6.04915639859385 2.35994738560483e-09 Non-alcoholic fatty liver disease (NAFLD): IL1A hsa04024__76 1.50036433848502e-09 UP 6.04469701311756 2.42406241789627e-09 cAMP signaling pathway: C00416 hsa04931__61 1.52125179368313e-09 DOWN -6.04246732037941 2.45569769787852e-09 Insulin resistance: ACACB hsa03320__58 1.58562895048123e-09 DOWN -6.03577824216497 2.55742214416672e-09 PPAR signaling pathway: CYP8B1 hsa04724__36 1.72244586876414e-09 DOWN -6.02240008573608 2.77570822247669e-09 Glutamatergic synapse: TRPC1 hsa04520__1 13 1.84518947226856e-09 DOWN -6.01125162204534 2.97096059845126e-09 Adherens junction: SMAD4 SMAD2 hsa04919__87 1.96741415977802e-09 UP 6.00084638926732 3.16504384094427e-09 Thyroid hormone signaling pathway: BAD hsa04620__21 2.30851170448054e-09 UP 5.97483330732227 3.71060179017873e-09 Toll-like receptor signaling pathway: IFNA1 hsa04910__18 2.3190588015623e-09 DOWN -5.97409007640955 3.72436879327826e-09 Insulin signaling pathway: LIPE hsa05200__200 2.37250233371893e-09 UP 5.97037392184598 3.80694439373004e-09 Pathways in cancer: FIGF hsa05200__52 2.42714478346598e-09 UP 5.9666577672824 3.891301235608e-09 Pathways in cancer: CDKN1B hsa04014__63 2.59852964901753e-09 UP 5.95550930359166 4.15897547743096e-09 Ras signaling pathway: TIAM1* hsa04024__109 2.59852964901753e-09 UP 5.95550930359166 4.15897547743096e-09 cAMP signaling pathway: BDNF hsa05020__52 2.71927468276748e-09 UP 5.9480769944645 4.34852521610222e-09 Prion diseases: FYN hsa04115__16 2.80702922828833e-09 UP 5.94287437807549 4.48504074826001e-09 p53 signaling pathway: PPM1D hsa04151__4 2.89753921131797e-09 DOWN -5.93767176168648 4.62572317592733e-09 PI3K-Akt signaling pathway: RPS6 hsa05200__184 3.17208182211369e-09 UP 5.92280714343216 5.05971285547676e-09 Pathways in cancer: GLI1 hsa04919__89 3.18645417292385e-09 DOWN -5.92206391251945 5.07832687949441e-09 Thyroid hormone signaling pathway: CASP9 hsa04961__12 3.64836044300003e-09 DOWN -5.89976698513798 5.80955023084496e-09 Endocrine and other factor-regulated calcium reabsorption: SLC8A1 hsa03460__16 34 3.97395116948966e-09 UP 5.88564559779638 6.32265389286289e-09 Fanconi anemia pathway: FANCM STRA13 hsa05169__29 4.13788554701536e-09 UP 5.87895651958193 6.57790773506079e-09 Epstein-Barr virus infection: FCER2 hsa04068__45 4.36673591545104e-09 DOWN -5.87003774862934 6.93583836443999e-09 FoxO signaling pathway: RBL2 hsa04540__21 4.4457215766768e-09 DOWN -5.86706482497848 7.05533010352678e-09 Gap junction: C03758 hsa05132__86 4.52609692776467e-09 DOWN -5.86409190132762 7.17682373609268e-09 Salmonella infection: MYH9 hsa04022__9 5.12967901471928e-09 UP 5.84328143577157 8.12703783192035e-09 cGMP-PKG signaling pathway: ITPR1 hsa04921__28 5.24540673838272e-09 UP 5.839565281208 8.30338606690913e-09 Oxytocin signaling pathway: EEF2 hsa05134__69 5.31605849532687e-09 UP 5.83733558846985 8.4081430241744e-09 Legionellosis: IL1B* hsa04540__11 5.78550432640459e-09 DOWN -5.82321420112825 9.14294586149219e-09 Gap junction: C00780 hsa04919__91 5.91559770592117e-09 DOWN -5.81949804656467 9.34067906674444e-09 Thyroid hormone signaling pathway: PFKP hsa04270__48 5.94195573506624e-09 UP 5.81875481565195 9.3744205089752e-09 Vascular smooth muscle contraction: KCNMB2* hsa04722__85 6.52261561912092e-09 UP 5.80314696648492 1.02818747888659e-08 Neurotrophin signaling pathway: BAX hsa04550__66 6.60994725114768e-09 UP 5.80091727374677 1.04108054357976e-08 Signaling pathways regulating pluripotency of stem cells: MYC hsa04261__66 6.63930971954658e-09 UP 5.80017404283406 1.04482939388845e-08 Adrenergic signaling in cardiomyocytes: C01245 hsa04921__23 6.69841571638092e-09 DOWN -5.79868758100863 1.0532487975799e-08 Oxytocin signaling pathway: C00219 hsa04261__37 7.35075430581683e-09 DOWN -5.7830797318416 1.1548551288152e-08 Adrenergic signaling in cardiomyocytes: CREB3 hsa05032__25 9.70047141888346e-09 DOWN -5.7362561843405 1.52273899716642e-08 Morphine addiction: C00575* hsa05010__49 1.06816920838934e-08 UP 5.71990510426075 1.67536723085439e-08 Alzheimer's disease: EIF2AK3 hsa04950__22 1.17591026744293e-08 UP 5.70355402418101 1.84281517308195e-08 Maturity onset diabetes of the young: NR5A2 hsa04211__51 1.23905502395707e-08 UP 5.69463525322842 1.94015365834611e-08 Longevity regulating pathway - mammal: NFKB1 hsa04925__33 1.60062788615888e-08 DOWN -5.65078462937818 2.50422964037679e-08 Aldosterone synthesis and secretion: CYP11B2 hsa04724__44 1.60756341773877e-08 DOWN -5.65004139846547 2.51089913709987e-08 Glutamatergic synapse: PRKACA* hsa04916__15 1.60756341773877e-08 DOWN -5.65004139846547 2.51089913709987e-08 Melanogenesis: MITF* hsa05215__12 1.77538109015932e-08 DOWN -5.63294708747301 2.77071517309748e-08 Prostate cancer: KLK3 hsa04068__67 1.78305082051624e-08 DOWN -5.63220385656029 2.78037551182573e-08 FoxO signaling pathway: GABARAP hsa04151__102 1.82188465641418e-08 UP 5.62848770199671 2.83857485025062e-08 PI3K-Akt signaling pathway: C8orf44-SGK3 hsa05218__8 1.83764707078577e-08 UP 5.62700124017128 2.86076126429698e-08 Melanoma: CDK4 hsa05152__15 1.84557785565333e-08 DOWN -5.62625800925856 2.87072913143428e-08 Tuberculosis: CTSD hsa05222__35 1.87763465272463e-08 UP 5.6232850856077 2.91817660253894e-08 Small cell lung cancer: NOS2 hsa04020__42 1.91023183065651e-08 DOWN -5.62031216195684 2.96638480149056e-08 Calcium signaling pathway: MYLK4 hsa05161__26 1.92673581212256e-08 UP 5.6188257001314 2.98954301484582e-08 Hepatitis B: MMP9 hsa04950__5 2.09957664207514e-08 DOWN -5.60396108187709 3.25503672480131e-08 Maturity onset diabetes of the young: GCK hsa04064__93 2.18218000991954e-08 DOWN -5.59727200366265 3.38031017200232e-08 NF-kappa B signaling pathway: PLAU hsa05166__53 146 2.19155058471692e-08 UP 5.59652877274993 3.39202928227602e-08 HTLV-I infection: CREB1 CRTC2 hsa04660__34 2.48094327273328e-08 UP 5.57497507628117 3.83678387610357e-08 T cell receptor signaling pathway: FOS hsa05134__68 2.54528771459001e-08 UP 5.57051569080488 3.93305560502847e-08 Legionellosis: TNF hsa04210__59 2.60014261873605e-08 UP 5.5667995362413 4.01451765045607e-08 Apoptosis: PMAIP1 hsa04151__5 2.6788708285716e-08 DOWN -5.56159691985229 4.1326751123859e-08 PI3K-Akt signaling pathway: EIF4B hsa05140__62 2.70178625629248e-08 DOWN -5.56011045802686 4.16460736306282e-08 Leishmaniasis: C00584 hsa04068__68 2.87982005343672e-08 UP 5.54896199433612 4.43539498394065e-08 FoxO signaling pathway: ATG12 hsa05030__80 81 3.18859340255451e-08 UP 5.53112445243094 4.90693448271902e-08 Cocaine addiction: GRIN3A DLG4 hsa04932__97 3.65063587049579e-08 UP 5.50734106322404 5.61337545062323e-08 Non-alcoholic fatty liver disease (NAFLD): TNF* hsa04914__15 3.84012583855113e-08 UP 5.49842229227145 5.89991533167422e-08 Progesterone-mediated oocyte maturation: ANAPC10 hsa04911__54 3.92186466054647e-08 DOWN -5.49470613770787 6.02057491598597e-08 Insulin secretion: RAB3A hsa04730__8 4.10767242709809e-08 DOWN -5.48653059766799 6.30066652287127e-08 Long-term depression: GNA13* hsa03320__30 4.28397526472631e-08 DOWN -5.47909828854084 6.56573370507401e-08 PPAR signaling pathway: LPL hsa04360__40 142 4.39325541781418e-08 UP 5.47463890306454 6.72773180935032e-08 Axon guidance: UNC5D PTPN11 hsa04390__95 4.60066276833812e-08 DOWN -5.46646336302467 7.03961347044571e-08 Hippo signaling pathway: AFP hsa04921__53 4.79742947540838e-08 DOWN -5.45903105389751 7.33471927118987e-08 Oxytocin signaling pathway: RGS2 hsa04723__46 4.81754895694758e-08 DOWN -5.45828782298479 7.35949145536952e-08 Retrograde endocannabinoid signaling: ADCY1 hsa04071__24 5.19400006317937e-08 UP 5.44490966655591 7.92812844737126e-08 Sphingolipid signaling pathway: PTEN hsa03320__29 5.28144772768897e-08 UP 5.44193674290505 8.05506516260356e-08 PPAR signaling pathway: OLR1 hsa04068__57 5.3927654928616e-08 UP 5.43822058834147 8.21817223121407e-08 FoxO signaling pathway: IL7R hsa04976__37 5.69293851015441e-08 UP 5.42855858647616 8.6685830312643e-08 Bile secretion: ABCB11 hsa04152__52 6.2381847331937e-08 DOWN -5.41220750639641 9.49113288556353e-08 AMPK signaling pathway: PCK1 hsa04710__5 6.50243891756306e-08 UP 5.40477519726926 9.87718894591834e-08 Circadian rhythm: RORA hsa05030__37 6.50243891756306e-08 DOWN -5.40477519726926 9.87718894591834e-08 Cocaine addiction: PRKACA hsa04340__26 6.69383574839087e-08 DOWN -5.39957258088025 1.01597070849971e-07 Hedgehog signaling pathway: PTCH1** hsa04064__54 6.94795015845984e-08 UP 5.3928835026658 1.05368832508039e-07 NF-kappa B signaling pathway: CCL13 hsa04925__18 7.73566504580095e-08 DOWN -5.37355949893519 1.17220279202097e-07 Aldosterone synthesis and secretion: PDE2A hsa05031__55 8.33096489963989e-08 UP 5.36018134250631 1.26139267094467e-07 Amphetamine addiction: GRIA1* hsa04022__23 8.39978485629893e-08 UP 5.35869488068088 1.26976635116538e-07 cGMP-PKG signaling pathway: CACNA1C hsa04390__14 8.39978485629893e-08 UP 5.35869488068088 1.26976635116538e-07 Hippo signaling pathway: AREG hsa05100__24 8.78824646655611e-08 DOWN -5.350519340641 1.3274208288311e-07 Bacterial invasion of epithelial cells: ACTB hsa05164__53 9.11896403643276e-08 UP 5.34383026242656 1.37626774493632e-07 Influenza A: MAPK14 hsa04724__65 9.69702627639608e-08 DOWN -5.33268179873582 1.46233646656085e-07 Glutamatergic synapse: GRM3 hsa04742__37 9.89731392713349e-08 UP 5.32896564417225 1.49134345381587e-07 Taste transduction: P2RY4 hsa04310__33 1.02267416749426e-07 UP 5.32301979687052 1.53974740442445e-07 Wnt signaling pathway: CCND1 hsa04723__40 1.05234152520654e-07 UP 5.31781718048151 1.5806152884597e-07 Retrograde endocannabinoid signaling: GRIA1 hsa04724__4 1.05234152520654e-07 UP 5.31781718048151 1.5806152884597e-07 Glutamatergic synapse: GRIA1 hsa05031__12 1.05234152520654e-07 UP 5.31781718048151 1.5806152884597e-07 Amphetamine addiction: GRIA1 hsa04726__38 1.09617261836238e-07 DOWN -5.31038487135435 1.64513446477868e-07 Serotonergic synapse: PLA2G4B hsa05321__19 1.17956076412038e-07 UP 5.29700671492547 1.76887045154205e-07 Inflammatory bowel disease (IBD): TNF hsa04722__33 1.28461580270697e-07 UP 5.28139886575843 1.92487487502903e-07 Neurotrophin signaling pathway: BAD hsa04724__51 1.32697172134464e-07 UP 5.27545301845671 1.98675686406899e-07 Glutamatergic synapse: ADRBK1 hsa04950__15 1.33776996906549e-07 DOWN -5.27396655663128 2.00132943620545e-07 Maturity onset diabetes of the young: IAPP hsa05145__11 1.41005900821915e-07 DOWN -5.26430455476597 2.10779703774367e-07 Toxoplasmosis: MAPK14 hsa04015__3 1.41577356939523e-07 UP 5.26356132385326 2.11465702455775e-07 Rap1 signaling pathway: MAPK1 hsa04728__36 1.59158622129606e-07 DOWN -5.2420076273845 2.37536974568332e-07 Dopaminergic synapse: TH hsa03320__25 1.61093997510236e-07 DOWN -5.23977793464635 2.40234620096614e-07 PPAR signaling pathway: EHHADH hsa04723__10 1.63709281226522e-07 UP 5.23680501099549 2.43747812539331e-07 Retrograde endocannabinoid signaling: CACNA1A hsa04723__21 1.63709281226522e-07 UP 5.23680501099549 2.43747812539331e-07 Retrograde endocannabinoid signaling: CACNA1A* hsa05161__227 1.66365596939972e-07 UP 5.23383208734462 2.47506695685041e-07 Hepatitis B: MYD88* hsa03320__8 1.68385133556363e-07 DOWN -5.23160239460648 2.5031302686108e-07 PPAR signaling pathway: GK hsa04510__44 1.93769312030676e-07 UP 5.20558931266142 2.87820187593391e-07 Focal adhesion: BCL2 hsa05031__101 2.17568739843138e-07 DOWN -5.18403561619267 3.2291600486987e-07 Amphetamine addiction: FOS* hsa05221__21 2.42249257849914e-07 DOWN -5.16396838154934 3.59263106156266e-07 Acute myeloid leukemia: PIM1 hsa04520__73 2.45152936762459e-07 DOWN -5.16173868881119 3.63282624745001e-07 Adherens junction: PARD3 hsa04919__102 2.57107507944778e-07 DOWN -5.1528199178586 3.80697405380802e-07 Thyroid hormone signaling pathway: BMP4 hsa05010__61 2.58128754711195e-07 UP 5.15207668694589 3.81908606379792e-07 Alzheimer's disease: GAPDH hsa04350__11 2.64339016065798e-07 DOWN -5.14761730146959 3.90789151209782e-07 TGF-beta signaling pathway: SMAD4* hsa05205__195 3.02350645511669e-07 UP 5.12234745043725 4.46632753865116e-07 Proteoglycans in cancer: CDKN1A hsa04950__13 3.04743790792066e-07 DOWN -5.12086098861182 4.49814283502194e-07 Maturity onset diabetes of the young: INS hsa05166__26 3.13264675254509e-07 UP 5.11565837222281 4.62028512404414e-07 HTLV-I infection: NFATC1 hsa04662__10 3.33613539202711e-07 DOWN -5.10376667761936 4.91654776597563e-07 B cell receptor signaling pathway: GSK3B hsa05014__32 34 3.4833738262668e-07 UP 5.09559113757949 5.12951365168913e-07 Amyotrophic lateral sclerosis (ALS): NEFM PRPH hsa04380__20 3.56630932913483e-07 UP 5.09113175210319 5.24752954537537e-07 Osteoclast differentiation: MAP2K1 hsa04921__41 3.58031593022722e-07 DOWN -5.09038852119048 5.26401692714941e-07 Oxytocin signaling pathway: PTGS2 hsa04115__24 4.25201147128927e-07 UP 5.05768636103098 6.24670019902466e-07 p53 signaling pathway: SERPINB5 hsa05032__37 4.40365289938874e-07 DOWN -5.05099728281654 6.46442484214956e-07 Morphine addiction: KCNJ3 hsa03320__10 4.66805224565564e-07 UP 5.0398488191258 6.84720544073923e-07 PPAR signaling pathway: PLIN1 hsa04921__11 4.70444192506975e-07 DOWN -5.03836235730037 6.89519998222001e-07 Oxytocin signaling pathway: PRKACA hsa05160__55 5.30470978587702e-07 DOWN -5.01532219900618 7.76893974096875e-07 Hepatitis C: MAPK14 hsa04810__21 82 5.73047586120519e-07 UP 5.00045758075186 8.38595338255806e-07 Regulation of actin cytoskeleton: CFL1 ACTB hsa04932__35 6.02469128870905e-07 DOWN -4.99079557888656 8.80964586107729e-07 Non-alcoholic fatty liver disease (NAFLD): PRKAG2 hsa05020__46 6.40682629717817e-07 DOWN -4.97890388428311 9.36114044509937e-07 Prion diseases: PRKACA hsa04213__62 6.45620470879028e-07 DOWN -4.97741742245767 9.4259585453123e-07 Longevity regulating pathway - multiple species: CAT* hsa04115__18 6.86465361389878e-07 UP 4.96552572785422 1.00145063202762e-06 p53 signaling pathway: CCNG1 hsa04010__88 92 6.89099190256742e-07 UP 4.96478249694151 1.00451309425323e-06 MAPK signaling pathway: ECSIT TRAF6 hsa04911__25 7.38206875922847e-07 DOWN -4.95140434051262 1.07526412392173e-06 Insulin secretion: PRKCA hsa04550__69 7.87670400298697e-07 UP 4.93876941499645 1.14642345636038e-06 Signaling pathways regulating pluripotency of stem cells: ID1 hsa04213__55 8.79505357162694e-07 DOWN -4.91721571852769 1.27909486540921e-06 Longevity regulating pathway - multiple species: CRYAB hsa04971__49 9.34499945937095e-07 UP 4.90532402392424 1.35802428338422e-06 Gastric acid secretion: KCNJ1 hsa04668__40 9.74213517511601e-07 UP 4.89714848388437 1.41464234884413e-06 TNF signaling pathway: JUN hsa04971__55 1.00411139613633e-06 DOWN -4.89120263658264 1.45693074389202e-06 Gastric acid secretion: MYLK4 hsa04510__43 1.07870041079821e-06 UP 4.87708124924104 1.56394912954463e-06 Focal adhesion: BAD hsa05169__93 1.10334288844557e-06 DOWN -4.87262186376475 1.59844355234327e-06 Epstein-Barr virus infection: PLCG1 hsa05200__187 1.14132503467178e-06 DOWN -4.86593278555031 1.65219548547633e-06 Pathways in cancer: WNT16* hsa04014__65 1.14562211813218e-06 DOWN -4.86518955463759 1.65713930713654e-06 Ras signaling pathway: MLLT4* hsa05031__97 1.16296664289024e-06 DOWN -4.86221663098673 1.68093409383905e-06 Amphetamine addiction: ARC hsa04911__4 1.23954085073025e-06 UP 4.84958170547056 1.79023617103931e-06 Insulin secretion: CACNA1C hsa04014__41 1.24886217323121e-06 UP 4.84809524364513 1.80231338210556e-06 Ras signaling pathway: RAC1* hsa05213__12 1.29164910794164e-06 UP 4.84140616543068 1.86263136901177e-06 Endometrial cancer: BAD hsa04115__23 1.33086276595023e-06 UP 4.83546031812896 1.91770792731632e-06 p53 signaling pathway: PTEN hsa04976__38 1.34084365208087e-06 UP 4.83397385630353 1.93060936571645e-06 Bile secretion: ABCC2 hsa04520__17 1.35089650876121e-06 UP 4.8324873944781 1.94359459415185e-06 Adherens junction: SNAI1 hsa04261__36 1.47732855483769e-06 UP 4.81464985257292 2.12387173262434e-06 Adrenergic signaling in cardiomyocytes: MAPK1 hsa04921__76 1.55625557984711e-06 UP 4.80424461979489 2.23563014872532e-06 Oxytocin signaling pathway: CDKN1A hsa04014__42 1.56204573112453e-06 UP 4.80350138888218 2.24223371182811e-06 Ras signaling pathway: PLA2G4B hsa05212__27 1.79145310663742e-06 DOWN -4.77600184511169 2.56957281478757e-06 Pancreatic cancer: BCL2L1* hsa04810__29 1.85196745639344e-06 UP 4.76931276689725 2.65434542377061e-06 Regulation of actin cytoskeleton: ACTN4 hsa04920__6 2.09110244553561e-06 DOWN -4.74478614677763 2.99480296887303e-06 Adipocytokine signaling pathway: PTPN11 hsa05020__24 2.11422263131104e-06 DOWN -4.74255645403948 3.01871149257861e-06 Prion diseases: PRNP* hsa05020__26 2.11422263131104e-06 DOWN -4.74255645403948 3.01871149257861e-06 Prion diseases: PRNP** hsa05020__25 8 2.11422263131104e-06 DOWN -4.74255645403948 3.01871149257861e-06 Prion diseases: PRNP PRNP* hsa05020__10 34 2.11422263131104e-06 DOWN -4.74255645403948 3.01871149257861e-06 Prion diseases: PRNP PRNP*** hsa04210__62 2.15339298949297e-06 DOWN -4.7388402994759 3.07230480429559e-06 Apoptosis: TP53AIP1 hsa04015__95 2.28336242338125e-06 UP 4.72694860487245 3.25526403151242e-06 Rap1 signaling pathway: THBS1 hsa04012__47 2.62291971073268e-06 DOWN -4.69870583018925 3.73651716183981e-06 ErbB signaling pathway: PRKCA hsa05212__29 2.72003364400857e-06 UP 4.69127352106209 3.87192667961523e-06 Pancreatic cancer: VEGFA hsa04620__39 2.73986621575598e-06 UP 4.68978705923666 3.89720561650681e-06 Toll-like receptor signaling pathway: IL6 hsa05205__30 2.75983751608868e-06 DOWN -4.68830059741123 3.92264348920622e-06 Proteoglycans in cancer: FLNA hsa04630__1 2.82059307759289e-06 UP 4.68384121193494 4.00596703915121e-06 Jak-STAT signaling pathway: MYC hsa04360__40 139 2.86180756109727e-06 DOWN -4.68086828828407 4.06143233179892e-06 Axon guidance: UNC5D DCC hsa05030__76 2.98894696516702e-06 DOWN -4.67194951733148 4.23866516796138e-06 Cocaine addiction: PDYN hsa04115__25 3.04350576256442e-06 DOWN -4.6682333627679 4.31278079024023e-06 p53 signaling pathway: CD82 hsa04610__57 3.3189607400233e-06 DOWN -4.65039582086272 4.69956837264791e-06 Complement and coagulation cascades: PLAUR hsa04920__16 3.37928270497763e-06 DOWN -4.64667966629915 4.78137967067242e-06 Adipocytokine signaling pathway: POMC hsa05215__34 3.39147261424185e-06 UP 4.64593643538643 4.79501658552328e-06 Prostate cancer: BAD hsa04727__8 3.41597905533823e-06 DOWN -4.644449973561 4.82603356765454e-06 GABAergic synapse: ADCY1 hsa04261__8 38 3.55382915004043e-06 UP 4.63627443352113 5.01701350332529e-06 Adrenergic signaling in cardiomyocytes: ATP2A2 PLN hsa05020__62 3.76389668321589e-06 UP 4.62438273891767 5.30958098180379e-06 Prion diseases: NOTCH1 hsa04330__19 4.51588640592085e-06 UP 4.58647796236917 6.36560431862361e-06 Notch signaling pathway: DTX2 hsa04922__24 4.61662749577364e-06 UP 4.58127534598016 6.50273093295252e-06 Glucagon signaling pathway: PFKL hsa05162__62 4.6461924317973e-06 DOWN -4.58053211506744 6.53947234408025e-06 Measles: IL12A hsa04151__26 4.90028644757919e-06 DOWN -4.5693836513767 6.89194478667762e-06 PI3K-Akt signaling pathway: RBL2 hsa03320__60 5.22278377164991e-06 UP 4.55600549494782 7.34002296703828e-06 PPAR signaling pathway: CYP27A1 hsa05034__61 5.39155817562158e-06 DOWN -4.54931641673338 7.57155292376155e-06 Alcoholism: CRH hsa04350__41 5.92978445865759e-06 DOWN -4.52924918209005 8.32118371756356e-06 TGF-beta signaling pathway: SMAD4*** hsa04071__89 5.99266705323923e-06 UP 4.5270194893519 8.40315029331082e-06 Sphingolipid signaling pathway: C00533 hsa04810__35 81 80 6.09889194563572e-06 DOWN -4.52330333478832 8.5457255524605e-06 Regulation of actin cytoskeleton: MYL12B MYH9 ACTB hsa04213__61 6.1203520630439e-06 DOWN -4.52256010387561 8.56940501226489e-06 Longevity regulating pathway - multiple species: ATG5 hsa05100__33 6.16348927751502e-06 UP 4.52107364205018 8.62337777546591e-06 Bacterial invasion of epithelial cells: DNM1 hsa04068__47 7.2146149649382e-06 DOWN -4.48762825097797 1.00790048469285e-05 FoxO signaling pathway: GADD45G hsa04068__54 7.2146149649382e-06 DOWN -4.48762825097797 1.00790048469285e-05 FoxO signaling pathway: GADD45G* hsa04933__26 7.26510209148094e-06 UP 4.48614178915253 1.01419961589099e-05 AGE-RAGE signaling pathway in diabetic complications: IL6 hsa04340__13 7.47044982116678e-06 UP 4.48019594185081 1.04209170111154e-05 Hedgehog signaling pathway: GLI1* hsa04919__42 8.12032351233692e-06 DOWN -4.46235839994563 1.13190562905646e-05 Thyroid hormone signaling pathway: SLC2A1 hsa04068__49 8.29104426034937e-06 DOWN -4.45789901446933 1.1548459722162e-05 FoxO signaling pathway: BCL2L11 hsa05231__18 8.88523651725846e-06 DOWN -4.44303439621502 1.23669329006879e-05 Choline metabolism in cancer: CHKA hsa04066__51 8.9778016790478e-06 UP 4.44080470347687 1.24865206180095e-05 HIF-1 signaling pathway: TFRC hsa05200__188 9.00886097647799e-06 DOWN -4.44006147256415 1.25204510168655e-05 Pathways in cancer: KLK3 hsa04390__12 9.4546178562938e-06 DOWN -4.42965623978613 1.31302490406327e-05 Hippo signaling pathway: CTGF hsa04530__5 11 31 9.68532271769604e-06 DOWN -4.42445362339712 1.34307906911814e-05 Tight junction: IGSF5 TJP1 MLLT4 hsa04742__18 9.68532271769604e-06 DOWN -4.42445362339712 1.34307906911814e-05 Taste transduction: PDE1A hsa05010__37 9.81955828487833e-06 UP 4.42148069974626 1.36068952929841e-05 Alzheimer's disease: MAPT hsa05231__34 1.01281157247186e-05 UP 4.41479162153182 1.4024118973284e-05 Choline metabolism in cancer: PLD1 hsa04152__27 1.0553955073917e-05 DOWN -4.40587285057923 1.46030055846023e-05 AMPK signaling pathway: ADIPOR1 hsa04064__129 1.10723808703059e-05 UP 4.39546761780121 1.53090534623288e-05 NF-kappa B signaling pathway: PTGS2 hsa05205__113 1.14574756170284e-05 DOWN -4.38803530867405 1.58298505032326e-05 Proteoglycans in cancer: TP53 hsa04740__33 1.16945711633027e-05 DOWN -4.38357592319776 1.6145554163002e-05 Olfactory transduction: CNGA3* hsa05140__26 1.23922969253748e-05 DOWN -4.37094099768159 1.70962745394855e-05 Leishmaniasis: C00533 hsa04068__51 1.3582612488354e-05 UP 4.35087376303826 1.86972372641884e-05 FoxO signaling pathway: BCL6 hsa04068__56 1.3582612488354e-05 UP 4.35087376303826 1.86972372641884e-05 FoxO signaling pathway: BCL6* hsa05221__41 1.3582612488354e-05 DOWN -4.35087376303826 1.86972372641884e-05 Acute myeloid leukemia: MAPK1 hsa04725__64 1.36287281809894e-05 DOWN -4.35013053212554 1.87469840791209e-05 Cholinergic synapse: KCNJ3 hsa04921__43 1.40981741107288e-05 DOWN -4.34269822299839 1.93785436386682e-05 Oxytocin signaling pathway: CACNG3 hsa04520__44 47 1.43386417088827e-05 DOWN -4.33898206843481 1.96946694232388e-05 Adherens junction: ACTB TJP1 hsa05161__92 1.50329364003804e-05 UP 4.32857683565679 2.06332268051971e-05 Hepatitis B: NFKBIA hsa05321__81 1.56534496645521e-05 DOWN -4.3196580647042 2.14692203793382e-05 Inflammatory bowel disease (IBD): IL13 hsa04360__108 1.58123510281832e-05 DOWN -4.31742837196605 2.16713403223604e-05 Axon guidance: CFL1 hsa04020__22 1.62436070313736e-05 DOWN -4.31148252466432 2.22461644401975e-05 Calcium signaling pathway: C00575 hsa04728__44 1.66301947038487e-05 DOWN -4.30627990827531 2.27590210113122e-05 Dopaminergic synapse: FOS hsa05214__23 1.80835570016157e-05 DOWN -4.28769913545742 2.47120026225715e-05 Glioma: MAPK1 hsa05214__56 1.80835570016157e-05 DOWN -4.28769913545742 2.47120026225715e-05 Glioma: MAPK1* hsa04020__64 1.9788822645805e-05 DOWN -4.26763190081409 2.70030484760113e-05 Calcium signaling pathway: C01330* hsa04020__12 1.9788822645805e-05 DOWN -4.26763190081409 2.70030484760113e-05 Calcium signaling pathway: C01330 hsa04728__64 2.02553152396304e-05 UP 4.26242928442508 2.76195481387994e-05 Dopaminergic synapse: SCN1A hsa04666__49 2.07322672817395e-05 UP 4.25722666803607 2.82494055274754e-05 Fc gamma R-mediated phagocytosis: ARF6* hsa04115__20 2.08012699708034e-05 UP 4.25648343712335 2.83228886051736e-05 p53 signaling pathway: RRM2B hsa05161__97 2.11495758292579e-05 UP 4.25276728255978 2.87762874606629e-05 Hepatitis B: BCL2 hsa04726__16 2.15748733234361e-05 DOWN -4.24830789708348 2.93124996201998e-05 Serotonergic synapse: ITPR1 hsa04726__46 2.15748733234361e-05 DOWN -4.24830789708348 2.93124996201998e-05 Serotonergic synapse: ITPR1* hsa04725__54 2.22281152060364e-05 DOWN -4.24161881886904 3.01781997631087e-05 Cholinergic synapse: CHRM1* hsa04024__123 2.35137163933348e-05 UP 4.22898389335287 3.19005581971669e-05 cAMP signaling pathway: PAK1 hsa05110__52 2.35915023995076e-05 DOWN -4.22824066244015 3.19829963987552e-05 Vibrio cholerae infection: ADCY3 hsa04917__45 2.37478095692692e-05 DOWN -4.22675420061472 3.21716901086206e-05 Prolactin signaling pathway: SLC2A2 hsa04725__18 2.39051018072284e-05 DOWN -4.22526773878929 3.23614454580563e-05 Cholinergic synapse: ITPR1 hsa04110__60 10 11 12 13 14 9 2.39841191562297e-05 DOWN -4.22452450787658 3.24450395209184e-05 Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 hsa04261__14 16 2.4788080642817e-05 DOWN -4.21709219874942 3.35084917466569e-05 Adrenergic signaling in cardiomyocytes: TNNI3 TPM1 hsa04360__11 2.4869872016669e-05 DOWN -4.2163489678367 3.35948882238109e-05 Axon guidance: NFATC2 hsa04012__43 2.55335079878424e-05 UP 4.21040312053497 3.44665671761177e-05 ErbB signaling pathway: PTK2 hsa05160__66 2.57866869852465e-05 DOWN -4.20817342779683 3.47833344187208e-05 Hepatitis C: GSK3B hsa04022__71 2.73566267283088e-05 UP 4.19479527136794 3.68745348798366e-05 cGMP-PKG signaling pathway: PPIF hsa04261__34 3.13807317902609e-05 UP 4.16357957303388 4.22381053251434e-05 Adrenergic signaling in cardiomyocytes: AKT3 hsa05205__81 3.13807317902609e-05 UP 4.16357957303388 4.22381053251434e-05 Proteoglycans in cancer: CTTN hsa04919__104 3.28427854016249e-05 DOWN -4.15317434025586 4.41743691980337e-05 Thyroid hormone signaling pathway: MYC hsa04152__57 3.31643923809992e-05 UP 4.15094464751771 4.45750309613001e-05 AMPK signaling pathway: ACACA* hsa05205__77 3.5157674832482e-05 DOWN -4.13756649108883 4.722035097229e-05 Proteoglycans in cancer: MIR21 hsa04950__16 3.70246695463859e-05 UP 4.12567479648537 4.96923957697565e-05 Maturity onset diabetes of the young: PAX4 hsa04310__13 3.89854563424865e-05 UP 4.11378310188192 5.22867041167253e-05 Wnt signaling pathway: NFATC1 hsa04261__39 3.9490834624658e-05 UP 4.11081017823106 5.2926731996956e-05 Adrenergic signaling in cardiomyocytes: SCN1B hsa05160__58 4.02605749915349e-05 UP 4.10635079275476 5.39199005054127e-05 Hepatitis C: EIF3E hsa04931__67 4.06505701819582e-05 UP 4.10412110001662 5.44034340255694e-05 Insulin resistance: IKBKB** hsa04014__100 4.37636819155207e-05 UP 4.08702678902415 5.85280842129988e-05 Ras signaling pathway: REL hsa04550__34 4.41860032006802e-05 DOWN -4.08479709628601 5.90508534950769e-05 Signaling pathways regulating pluripotency of stem cells: MAPK1* hsa05211__43 4.47551141029736e-05 UP 4.08182417263514 5.97689121531539e-05 Renal cell carcinoma: RAP1A hsa05120__50 4.50422699317707e-05 UP 4.08033771080971 6.01096769899128e-05 Epithelial cell signaling in Helicobacter pylori infection: EGFR hsa04068__96 4.59142582617287e-05 DOWN -4.07587832533342 6.12298731538596e-05 FoxO signaling pathway: CCNG2 hsa04520__34 4.77064756407771e-05 DOWN -4.06695955438083 6.35747998078157e-05 Adherens junction: RHOA hsa04012__3 4.9093976794864e-05 UP 4.06027047616638 6.53774503171859e-05 ErbB signaling pathway: ELK1 hsa04921__80 5.08417664326168e-05 UP 4.05209493612651 6.76569965487868e-05 Oxytocin signaling pathway: KCNJ2 hsa04390__18 5.23154768534741e-05 DOWN -4.04540585791207 6.95688471391917e-05 Hippo signaling pathway: MOB1A hsa04915__58 5.59131195683695e-05 DOWN -4.02979800874504 7.43003901477838e-05 Estrogen signaling pathway: CREB3*** hsa04728__70 73 6.12681286331551e-05 UP 4.00824431227628 8.13588789411296e-05 Dopaminergic synapse: KIF5A GRIA1 hsa04550__47 6.16548003265745e-05 DOWN -4.00675785045085 8.18145267045434e-05 Signaling pathways regulating pluripotency of stem cells: CTNNB1* hsa04390__60 6.26316125031361e-05 DOWN -4.00304169588727 8.30520817878566e-05 Hippo signaling pathway: CTGF* hsa04068__88 7.18823092894884e-05 DOWN -3.97033953572777 9.5251663719992e-05 FoxO signaling pathway: FBXO32 hsa04068__59 7.65015891252884e-05 UP 3.95547491747346 0.000101301258609173 FoxO signaling pathway: S1PR1 hsa04014__30 8.39598659464891e-05 DOWN -3.93317799009198 0.000111099005713699 Ras signaling pathway: C01245 hsa05161__48 9.15364628301552e-05 DOWN -3.91236752453594 0.000121039418478439 Hepatitis B: STAT1 hsa03320__39 9.49774160353781e-05 UP 3.90344875358335 0.000125501100373049 PPAR signaling pathway: MMP1 hsa04540__14 16 9.61512908967399e-05 UP 3.90047582993249 0.000126873789041415 Gap junction: GJA1 GJA1 hsa04540__14 15 9.61512908967399e-05 UP 3.90047582993249 0.000126873789041415 Gap junction: GJA1 GJA1* hsa04727__17 37 9.85402358875963e-05 DOWN -3.89452998263076 0.000129934809286171 GABAergic synapse: GABRA1 GPHN hsa05221__26 0.000108007348281795 UP 3.87223305524929 0.000142318238023487 Acute myeloid leukemia: BAD hsa04340__32 0.000108668075504909 UP 3.87074659342386 0.000143088517080395 Hedgehog signaling pathway: PTCH1*** hsa05205__145 0.00011101069835332 DOWN -3.86554397703485 0.000146070799864067 Proteoglycans in cancer: PXN hsa04950__31 0.00011237077134069 UP 3.86257105338398 0.000147756948459872 Maturity onset diabetes of the young: NKX6-1* hsa05321__123 0.000112713217334199 DOWN -3.86182782247127 0.000148103591168503 Inflammatory bowel disease (IBD): IL5* hsa05211__23 0.000117612013294048 UP 3.85142258969325 0.000154432545757873 Renal cell carcinoma: PDGFB hsa04668__111 0.000128018071859772 UP 3.8306121241372 0.000167979020268513 TNF signaling pathway: BAG4 hsa04728__32 0.000129965296657093 UP 3.82689596957362 0.000170415067982329 Dopaminergic synapse: CREB3 hsa04722__35 0.000135159522861297 UP 3.81723396770832 0.000177102331559537 Neurotrophin signaling pathway: FOXO3 hsa04024__112 0.000138036808033545 UP 3.81203135131931 0.000180746454560997 cAMP signaling pathway: GLI1 hsa04151__100 0.00013886942759488 DOWN -3.81054488949388 0.000181710065773524 PI3K-Akt signaling pathway: PRKCA hsa04068__43 0.000147018740538775 UP 3.79642350215228 0.000192239536167264 FoxO signaling pathway: CDKN1A hsa05223__22 0.00015013304871368 UP 3.79122088576327 0.000196175242373439 Non-small cell lung cancer: BAD* hsa04921__48 0.000151486674801577 DOWN -3.78899119302512 0.000197806436380933 Oxytocin signaling pathway: PRKAG2 hsa05161__44 0.0001556168147619 UP 3.78230211481068 0.000203058329817785 Hepatitis B: CXCL8 hsa04014__55 0.000162736766677295 DOWN -3.77115365111994 0.000212201516021261 Ras signaling pathway: MLLT4 hsa04213__13 0.000164686553590928 DOWN -3.76818072746908 0.000214595030650037 Longevity regulating pathway - multiple species: RPS6KB1* hsa05168__79 0.000166658303628036 UP 3.76520780381821 0.000217013827108163 Herpes simplex infection: EIF2S1 hsa04666__42 0.000193254639582492 DOWN -3.72804625818242 0.000251471930592453 Fc gamma R-mediated phagocytosis: MYO10 hsa04022__58 0.000201387655065207 DOWN -3.7176410254044 0.00026187363589448 cGMP-PKG signaling pathway: MYH7 hsa05231__59 0.0002331353173128 DOWN -3.68047947976861 0.000302946930311723 Choline metabolism in cancer: PLA2G4B hsa04152__24 0.000237246009190192 DOWN -3.67602009429232 0.00030807550191318 AMPK signaling pathway: SIRT1 hsa05032__31 0.000237937701338109 DOWN -3.6752768633796 0.000308334441940902 Morphine addiction: GABRR3 hsa05032__33 0.000237937701338109 DOWN -3.6752768633796 0.000308334441940902 Morphine addiction: GABRR3* hsa05032__55 0.000237937701338109 DOWN -3.6752768633796 0.000308334441940902 Morphine addiction: GABRR3** hsa05166__114 112 113 0.000240024147772222 UP 3.67304717064146 0.00031082382747347 HTLV-I infection: DLG1 CTNNB1 APC2 hsa05152__94 0.0002471036079617 DOWN -3.6656148615143 0.000319771129035836 Tuberculosis: CAMP hsa04931__144 0.000282265429184389 DOWN -3.63142623952937 0.000365021845449048 Insulin resistance: C00533* hsa04115__22 0.000297259650487151 UP 3.61804808310049 0.000384147787665308 p53 signaling pathway: STEAP3 hsa04014__35 0.000298114156712898 UP 3.61730485218777 0.000384987285541949 Ras signaling pathway: NFKB1 hsa04540__14 31 0.000320239431613373 UP 3.59872407936988 0.000413276024726324 Gap junction: GJA1 TJP1 hsa04750__7 0.000321154575270226 UP 3.59798084845716 0.000413888509556074 Inflammatory mediator regulation of TRP channels: TRPV1 hsa04750__58 0.000321154575270226 UP 3.59798084845716 0.000413888509556074 Inflammatory mediator regulation of TRP channels: TRPV1** hsa05200__192 0.000322074290562249 DOWN -3.59723761754444 0.000414789302238839 Pathways in cancer: PTGS2 hsa04915__66 0.000324845037678661 DOWN -3.5950079248063 0.000418071113560414 Estrogen signaling pathway: AKT3* hsa05161__68 0.000337111390183263 DOWN -3.58534592294099 0.000433560781762047 Hepatitis B: JUN hsa04930__3 0.000375497543489856 DOWN -3.55710314825779 0.000482599100011929 Type II diabetes mellitus: SLC2A4 hsa04360__96 0.000385169030927427 DOWN -3.55041407004335 0.000494690778614242 Axon guidance: GSK3B hsa04740__13 0.000406356088760353 DOWN -3.53629268270175 0.000521545827036 Olfactory transduction: CNGA3 hsa05210__9 11 0.000417939698701793 DOWN -3.52886037357459 0.000536046890007282 Colorectal cancer: SMAD2 SMAD4 hsa05014__2 0.000427427841152726 UP 3.52291452627286 0.000547842369390158 Amyotrophic lateral sclerosis (ALS): SLC1A2 hsa04152__63 0.0004346755236365 DOWN -3.51845514079657 0.000556372826235003 AMPK signaling pathway: PPARG hsa05145__35 0.0004346755236365 UP 3.51845514079657 0.000556372826235003 Toxoplasmosis: CASP3 hsa04062__60 0.000452035333822207 DOWN -3.50804990801855 0.000578199041696342 Chemokine signaling pathway: GSK3A hsa04550__36 0.000470040444695896 DOWN -3.49764467524053 0.000600820405158903 Signaling pathways regulating pluripotency of stem cells: AKT3* hsa04022__51 0.000475306344068636 DOWN -3.49467175158967 0.000607138423184886 cGMP-PKG signaling pathway: GTF2I hsa04919__32 0.000494173495925939 DOWN -3.48426651881164 0.00063080978182394 Thyroid hormone signaling pathway: PLN hsa04024__21 0.000508075097213171 UP 3.47683420968449 0.000648114804931126 cAMP signaling pathway: AKT3 hsa04066__48 0.000509485127856215 UP 3.47609097877177 0.000649472561222408 HIF-1 signaling pathway: PFKFB3 hsa04930__13 0.000520897400732352 UP 3.47014513147004 0.000663570315915993 Type II diabetes mellitus: C00162 hsa04728__68 0.000526692463485722 UP 3.46717220781918 0.000670044102159561 Dopaminergic synapse: CACNA1C hsa05161__78 0.000526692463485722 UP 3.46717220781918 0.000670044102159561 Hepatitis B: TNF hsa05231__21 0.000538463266107391 UP 3.46122636051745 0.000684555126533009 Choline metabolism in cancer: PCYT1A hsa04924__30 0.000551998172615631 DOWN -3.45453728230301 0.000701287739245958 Renin secretion: PDE3A hsa04022__46 0.000559653836696155 UP 3.45082112773943 0.000710533485913565 cGMP-PKG signaling pathway: VASP hsa04670__54 0.000578432741285511 UP 3.44190235678684 0.00073387921733658 Leukocyte transendothelial migration: RAC1* hsa04723__42 0.000604384672350396 UP 3.43001066218339 0.000765771274002963 Retrograde endocannabinoid signaling: KCNJ3 hsa04723__50 0.000604384672350396 UP 3.43001066218339 0.000765771274002963 Retrograde endocannabinoid signaling: KCNJ3* hsa04022__48 0.000634873913043174 DOWN -3.41663250575451 0.000803859893940784 cGMP-PKG signaling pathway: SLC8A2 hsa05169__11 0.000643040808076228 UP 2.50840433041581 0.00081365230867019 Epstein-Barr virus infection: HLA-A hsa04931__46 0.00064359362485705 UP 3.41291635119093 0.000813803782709554 Insulin resistance: PIK3R5* hsa05030__69 0.000659570411260972 DOWN -3.40622727297649 0.000833445059017732 Cocaine addiction: PRKACA** hsa04750__40 0.000663170535173869 DOWN -3.40474081115105 0.00083743107230625 Inflammatory mediator regulation of TRP channels: C00219 hsa05213__11 0.000688887571201894 UP 3.39433557837303 0.000869321522020389 Endometrial cancer: FOXO3 hsa05160__85 0.000692636199959766 UP 3.3928491165476 0.000873465382365369 Hepatitis C: BAD hsa04014__67 0.000702090875086627 UP 3.38913296198402 0.000884201577940865 Ras signaling pathway: RAPGEF5* hsa04360__81 0.000702090875086627 DOWN -3.38913296198402 0.000884201577940865 Axon guidance: FYN* hsa05205__158 0.000709740817146572 UP 3.38616003833316 0.000893237103428271 Proteoglycans in cancer: PDCD4 hsa04924__58 0.000727237234846608 DOWN -3.37947096011872 0.000914032618245336 Renin secretion: PPP3CA hsa05031__59 0.000727237234846608 DOWN -3.37947096011872 0.000914032618245336 Amphetamine addiction: PPP3CA hsa04520__43 0.000729205419377537 DOWN -3.378727729206 0.000915893705220851 Adherens junction: ACTB hsa03320__53 0.000745133626924791 DOWN -3.37278188190427 0.000935274605872868 PPAR signaling pathway: ADIPOQ hsa05200__216 0.000801306661814149 UP 3.35271464726095 0.00100511029208864 Pathways in cancer: IL6 hsa04213__71 0.000849956243665051 UP 3.3363635671812 0.00106542213598841 Longevity regulating pathway - multiple species: SIRT1** hsa04022__63 0.00089178288853859 UP 3.32298541075232 0.00111710669837601 cGMP-PKG signaling pathway: C00575 hsa04728__54 0.000896546240000975 UP 3.32149894892688 0.00112232537305918 Dopaminergic synapse: CAMK2A hsa04340__17 0.000983816717856317 UP 3.29548586698183 0.00123075340402931 Hedgehog signaling pathway: SMO hsa04390__58 0.00101282874370133 UP 3.28731032694196 0.00126536250625984 Hippo signaling pathway: SMAD7 hsa05217__10 0.00101282874370133 DOWN -3.28731032694196 0.00126536250625984 Basal cell carcinoma: PTCH1* hsa04550__17 0.00104538010571045 UP 3.27839155598937 0.00130516227151491 Signaling pathways regulating pluripotency of stem cells: AKT3 hsa04115__40 0.00107324284407821 DOWN -3.27095924686221 0.00133905929882002 p53 signaling pathway: PIDD1 hsa04931__77 0.00113695231853511 UP 3.25460816678246 0.00141669575016491 Insulin resistance: PPP2R4** hsa04910__24 0.00113697562067519 DOWN -3.25460816678246 0.00141669575016491 Insulin signaling pathway: ACACA hsa04920__28 0.0011399540531242 UP 3.25386493586975 0.00141946564998037 Adipocytokine signaling pathway: SLC2A1 hsa05231__60 0.00119481432527089 UP 3.24048677944086 0.00148679213058543 Choline metabolism in cancer: PRKCA hsa04931__40 0.00120733217179841 DOWN -3.23751385579 0.0015013746861742 Insulin resistance: PRKCZ hsa05216__5 0.00136729661351694 UP 3.20183877197964 0.00169917350317349 Thyroid cancer: MAPK1 hsa04151__25 0.00146941650519561 UP 3.1810283064236 0.00182487350513056 PI3K-Akt signaling pathway: CDKN1B hsa04310__16 0.001484565761926 UP 3.17805538277274 0.00184246966093722 Wnt signaling pathway: CAMK2A hsa05223__9 0.00150755964285308 UP 3.17359599729644 0.00186977199268709 Non-small cell lung cancer: BAD hsa04919__18 0.00154661305063439 DOWN -3.16616368816928 0.00191694322041031 Thyroid hormone signaling pathway: STAT1 hsa04724__67 0.00155850948367537 DOWN -3.16393399543114 0.00193041484497431 Glutamatergic synapse: PLD1 hsa04115__36 0.00161104070807636 UP 3.15427199356583 0.00199416698977304 p53 signaling pathway: EI24 hsa04360__145 0.00162752909533814 DOWN -3.15129906991497 0.0020132502765901 Axon guidance: ABLIM3 hsa04360__35 0.00163999715106787 DOWN -3.14906937717682 0.00202733858345824 Axon guidance: ROCK1* hsa04810__32 0.00164835795481832 UP 3.14758291535139 0.00203633438336859 Regulation of actin cytoskeleton: PXN hsa05031__10 0.00177856824418839 UP 3.12528598796992 0.00219430711151017 Amphetamine addiction: CACNA1C hsa05031__53 0.00177856824418839 UP 3.12528598796992 0.00219430711151017 Amphetamine addiction: CACNA1C* hsa04012__37 7 0.00191336300755304 UP 3.10373229150116 0.00235906108345943 ErbB signaling pathway: ERBB3 ERBB3 hsa04923__38 0.00194239723379786 DOWN -3.09927290602486 0.00239328813265979 Regulation of lipolysis in adipocytes: PDE3B hsa04310__35 0.00200669742819453 DOWN -3.08961090415956 0.00247089414651213 Wnt signaling pathway: JUN hsa04725__43 0.00201676137531137 DOWN -3.08812444233413 0.00248165987178131 Cholinergic synapse: CREB3 hsa05169__79 0.00205235103855095 UP 3.08292182594511 0.00252380078628091 Epstein-Barr virus infection: ATF2 hsa04510__19 23 0.00217338426749614 DOWN -3.06582751495265 0.00267088884148152 Focal adhesion: VCL TLN1 hsa04921__34 35 0.0021896447277529 UP 3.0635978222145 0.00268911270813575 Oxytocin signaling pathway: MYL9 ACTB hsa04022__66 0.00222250064976056 DOWN -3.05913843673821 0.00272768041861534 cGMP-PKG signaling pathway: PDE3A hsa04510__19 26 0.00223909747865082 DOWN -3.05690874400006 0.00274446455471943 Focal adhesion: VCL ACTN4 hsa04917__31 0.00223909747865082 DOWN -3.05690874400006 0.00274446455471943 Prolactin signaling pathway: GALT hsa04950__11 0.00231806124517355 UP 3.04650351122204 0.0028393983570281 Maturity onset diabetes of the young: HNF4G hsa04910__39 0.00238188448958566 UP 3.03832797118217 0.00291567488985762 Insulin signaling pathway: BAD hsa04742__67 0.00239956788776585 UP 3.03609827844402 0.00293540889395314 Taste transduction: PRKACA hsa05205__91 0.00242333270007346 UP 3.03312535479316 0.00296255181746131 Proteoglycans in cancer: RAC1* hsa05222__36 0.00264711238146899 DOWN -3.00636904193539 0.00323402091338116 Small cell lung cancer: PTGS2 hsa04933__23 0.00266008170652436 DOWN -3.00488258010996 0.00324775407833611 AGE-RAGE signaling pathway in diabetic complications: F3 hsa04152__53 0.0027458076885166 DOWN -2.99522057824465 0.00335024197839136 AMPK signaling pathway: G6PC hsa04611__43 0.00275250541621641 UP 2.99447734733194 0.00335623470283624 Platelet activation: MYL12B hsa04724__13 0.0027592112055712 UP 2.99373411641922 0.0033622294781247 Glutamatergic synapse: GRM5 hsa04068__66 0.00293197088154613 DOWN -2.97515334360132 0.00357042986806557 FoxO signaling pathway: BNIP3 hsa04914__23 0.00311454092876381 DOWN -2.95657257078343 0.00379029948519896 Progesterone-mediated oocyte maturation: PRKACA hsa05217__22 0.00318276339239048 UP 2.94988349256899 0.00387081709663541 Basal cell carcinoma: LEF1 hsa04925__3 0.00323676389169112 DOWN -2.94468087617998 0.00393394524740466 Aldosterone synthesis and secretion: ITPR1 hsa05220__50 0.00350275600585869 UP 2.92015425606036 0.00425447869102034 Chronic myeloid leukemia: MAPK1 hsa04550__60 0.00356167482700752 DOWN -2.91495163967135 0.00432324741598652 Signaling pathways regulating pluripotency of stem cells: MAPK14 hsa05205__188 0.00357016500763719 UP 2.91420840875863 0.00433075535787623 Proteoglycans in cancer: TNF hsa04115__19 0.00358720062423196 UP 2.9127219469332 0.00434861288576248 p53 signaling pathway: RFWD2 hsa04360__18 0.00368222523396286 UP 2.90454640689332 0.00446092921638698 Axon guidance: PTK2 hsa04014__76 0.00373501610974046 DOWN -2.90008702141703 0.00452196860193449 Ras signaling pathway: RALBP1* hsa04014__66 0.00374388117579589 DOWN -2.89934379050431 0.00452686790818563 Ras signaling pathway: RAF1* hsa05010__59 0.00374388117579589 UP 2.89934379050431 0.00452686790818563 Alzheimer's disease: LRP1 hsa04115__50 0.00387917217059512 UP 2.88819532681358 0.00468743698298922 p53 signaling pathway: RCHY1 hsa04151__28 0.00403785988632488 DOWN -2.87556040129741 0.0048760531660697 PI3K-Akt signaling pathway: BCL2L11 hsa04924__31 0.00426193021476695 DOWN -2.85846609030494 0.00514333132533532 Renin secretion: C02135 hsa04810__31 0.00434247914360881 UP 2.85252024300322 0.00523717478231127 Regulation of actin cytoskeleton: MSN hsa04014__43 0.00460315341698269 UP 2.83393947018532 0.00554799568345765 Ras signaling pathway: ELK1 hsa05145__67 0.00462460751293696 UP 2.83245300835989 0.00557028045949266 Toxoplasmosis: BAD hsa03320__65 0.00464615211629193 DOWN -2.83096654653446 0.00559264562877165 PPAR signaling pathway: ME1 hsa04261__15 16 0.00481065544480513 DOWN -2.81981808284372 0.00578695363686866 Adrenergic signaling in cardiomyocytes: ACTC1 TPM1 hsa05142__44 0.00528753097117453 UP 2.78934561542238 0.00635653915216695 Chagas disease (American trypanosomiasis): PLCB1 hsa05223__21 0.00537308916865461 UP 2.78414299903337 0.00645526505620334 Non-small cell lung cancer: FOXO3* hsa04064__135 0.00538541329026895 UP 2.78339976812065 0.00646593710697467 NF-kappa B signaling pathway: CCL19 hsa05231__48 0.0057149330012119 DOWN -2.76407576439004 0.00685718972495349 Choline metabolism in cancer: WAS hsa05215__43 0.00584641282011266 UP 2.75664345526288 0.00700603188526586 Prostate cancer: C05981 hsa04970__21 0.00584643852905635 UP 2.75664345526288 0.00700603188526586 Salivary secretion: ITPR1 hsa04110__43 83 84 85 0.00625748119227027 DOWN -2.73434652788141 0.0074938222818839 Cell cycle: SMC1B SMC3 STAG1 RAD21 hsa04810__23 0.006299983866047 UP 2.73211683514326 0.0075399169963709 Regulation of actin cytoskeleton: GSN hsa04012__48 0.00675463562832557 UP 2.70907667684907 0.00807890537595401 ErbB signaling pathway: CAMK2A hsa04068__55 0.00693840299812504 UP 2.70015790589648 0.00829342190424743 FoxO signaling pathway: ATM hsa05200__173 0.00756706544444439 DOWN -2.67117190030056 0.00903336465699555 Pathways in cancer: CCNA1 hsa05221__16 0.00756706544444439 DOWN -2.67117190030056 0.00903336465699555 Acute myeloid leukemia: CCNA1 hsa05010__50 0.00768516046849239 UP 2.66596928391155 0.00916851842558553 Alzheimer's disease: ERN1 hsa04725__50 0.00803172949412522 DOWN -2.65110466565724 0.00957590083722163 Cholinergic synapse: BCL2 hsa04913__40 0.00821020745467832 UP 2.64367235653008 0.00978248561023498 Ovarian steroidogenesis: HSD17B1 hsa05164__65 66 0.00861540782299978 UP 2.62732127645033 0.0102587777562843 Influenza A: DNAJC3 HSPA1A hsa04950__1 0.00899918652498579 DOWN -2.61245665819602 0.0107089749717849 Maturity onset diabetes of the young: HNF1B hsa03320__45 0.00960350218488576 UP 2.59015973081454 0.0114208738008863 PPAR signaling pathway: PDPK1 hsa04022__3 0.00966588028480463 DOWN -2.5879300380764 0.0114877856136293 cGMP-PKG signaling pathway: MYL9 hsa05205__238 0.00983399014797361 DOWN -2.58198419077467 0.0116801943666513 Proteoglycans in cancer: ITGAV* hsa04950__30 0.0100477907182311 UP 2.57455188164751 0.0119265942890438 Maturity onset diabetes of the young: PAX6* hsa05031__98 0.0102877426435636 DOWN -2.56637634160764 0.0122037048151868 Amphetamine addiction: FOS hsa04728__71 72 0.0103098073409328 UP 2.56563311069492 0.0122221627719954 Dopaminergic synapse: CLOCK ARNTL hsa04210__114 0.0111563841321738 UP 2.53813356692444 0.0132174311376763 Apoptosis: HRK hsa04630__7 0.0114439146743327 DOWN -2.52921479597185 0.0135495372861192 Jak-STAT signaling pathway: BCL2 hsa04022__43 0.0122173661028711 DOWN -2.50617463767766 0.0144561907476667 cGMP-PKG signaling pathway: MAPK1 hsa04740__16 0.0122430694772616 UP 2.50543140676494 0.0144774874435334 Olfactory transduction: PRKG1 hsa04360__33 134 0.0125027501321051 UP 2.49799909763778 0.0147752625775003 Axon guidance: NCK1 PAK4 hsa03320__33 0.0125552676930795 DOWN -2.49651263581235 0.0148279999970436 PPAR signaling pathway: CYP7A1 hsa05221__5 0.0127672962724089 DOWN -2.49056678851063 0.015068938251166 Acute myeloid leukemia: SPI1 hsa04725__61 0.0133112909837027 UP 2.47570217025631 0.0157011398357674 Cholinergic synapse: FOS hsa04115__56 0.0137896922476223 UP 2.46306724474014 0.0162552269343051 p53 signaling pathway: SESN3 hsa04520__69 0.0144610810678255 DOWN -2.44597293374768 0.017035969483664 Adherens junction: IQGAP1** hsa05016__55 0.0147012752163137 UP 2.44002708644595 0.0173080802828656 Huntington's disease: TGM2 hsa04662__16 0.0150990949035748 UP 2.43036508458065 0.0177653095327596 B cell receptor signaling pathway: VAV3 hsa04210__86 0.0153485926317076 UP 2.42441923727892 0.0180475629255185 Apoptosis: BCL2L11 hsa04924__23 0.0155063652775166 UP 2.42070308271534 0.0182216762704526 Renin secretion: ITPR1 hsa04630__36 0.0156655633811748 DOWN -2.41698692815176 0.0183972459957671 Jak-STAT signaling pathway: GFAP hsa04010__54 0.0160535186084404 DOWN -2.40806815719917 0.0188410752437599 MAPK signaling pathway: NR4A1 hsa04015__96 0.0162837050122039 DOWN -2.40286554081016 0.0190993019462741 Rap1 signaling pathway: PLCE1 hsa04024__62 0.0164833108576456 DOWN -2.39840615533387 0.0193213606372527 cAMP signaling pathway: BAD hsa04740__42 0.0170261363094863 UP 2.38651446073042 0.0199452058139182 Olfactory transduction: PDE2A hsa04150__33 0.0171989560534231 UP 2.38279830616684 0.0201225643987435 mTOR signaling pathway: RPS6 hsa05164__99 0.0171989560534231 DOWN -2.38279830616684 0.0201225643987435 Influenza A: FDPS hsa05200__186 0.0179777724083304 DOWN -2.36644722608709 0.02102068099269 Pathways in cancer: PTCH1* hsa04728__61 0.018452359207736 DOWN -2.35678522422178 0.0215621784523234 Dopaminergic synapse: KCNJ3 hsa04740__37 0.0186377915492408 UP 2.3530690696582 0.0217653264891382 Olfactory transduction: CNGB1* hsa04064__97 0.0188624607940426 UP 2.34860968418191 0.0220140148024882 NF-kappa B signaling pathway: PLCG2 hsa05205__270 0.0193959215169497 DOWN -2.33820445140389 0.0226225552640276 Proteoglycans in cancer: MAPK1**** hsa04725__53 0.0194344873698785 DOWN -2.33746122049117 0.0226534750421846 Cholinergic synapse: CHRNA7 hsa04014__69 0.0201409644508603 DOWN -2.32408306406229 0.023462413021182 Ras signaling pathway: PLCE1* hsa04068__53 0.0202208242305683 DOWN -2.32259660223686 0.0235408480354633 FoxO signaling pathway: SOD2 hsa05120__19 0.0203411319132509 UP 2.32036690949871 0.0236662457368412 Epithelial cell signaling in Helicobacter pylori infection: CXCL1 hsa04750__51 0.0204216703768098 DOWN -2.31888044767328 0.0237305619282781 Inflammatory mediator regulation of TRP channels: TRPV4 hsa04750__61 0.0204216703768098 DOWN -2.31888044767328 0.0237305619282781 Inflammatory mediator regulation of TRP channels: TRPV4* hsa05142__36 0.0204620635448929 DOWN -2.31813721676056 0.0237628043268565 Chagas disease (American trypanosomiasis): SMAD2 hsa05221__13 0.0220489931833582 DOWN -2.28989444207736 0.0255899062331872 Acute myeloid leukemia: NFKB1 hsa04915__3 11 0.022926441343074 DOWN -2.27502982382305 0.0265590525793071 Estrogen signaling pathway: ESR1 C00951 hsa04915__12 14 0.022926441343074 DOWN -2.27502982382305 0.0265590525793071 Estrogen signaling pathway: ESR1 FOS hsa04915__12 13 0.022926441343074 DOWN -2.27502982382305 0.0265590525793071 Estrogen signaling pathway: ESR1 C00951* hsa05205__140 0.0229710989995725 UP 2.27428659291033 0.0265943900309283 Proteoglycans in cancer: MAPK1*** hsa04150__56 0.0240192828368247 UP 2.25719228191787 0.0277907835285675 mTOR signaling pathway: EIF4B hsa04726__39 0.0253024596808141 DOWN -2.23712504727454 0.0292574287632306 Serotonergic synapse: CACNA1C hsa04014__64 0.0255464862272512 UP 2.23340889271096 0.029521431501233 Ras signaling pathway: PIK3R5* hsa04740__39 0.0266445426507391 UP 2.21705781263121 0.0307714171117018 Olfactory transduction: PRKG1* hsa04340__33 0.0279945891208323 DOWN -2.1977338089006 0.0323107082051866 Hedgehog signaling pathway: HHIP* hsa04750__60 0.0280476146146489 UP 2.19699057798789 0.0323520367470383 Inflammatory mediator regulation of TRP channels: TRPV3 hsa04550__53 64 0.0285832763159024 UP 2.18955826886073 0.0329496786488224 Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4 hsa05205__422 0.0287999627106374 DOWN -2.18658534520987 0.0331791109339594 Proteoglycans in cancer: CD63 hsa05145__10 0.0305278321601067 DOWN -2.16354518691568 0.0351481596990444 Toxoplasmosis: MAPK8 hsa04910__17 0.0305850210337229 UP 2.16280195600296 0.0351924400014485 Insulin signaling pathway: C00031 hsa05162__27 28 0.0311038742811307 UP 2.15611287778852 0.0357675518814226 Measles: STAT1 IRF9 hsa04022__65 0.0312784958161662 DOWN -2.15388318505037 0.0359463569654901 cGMP-PKG signaling pathway: PDE2A hsa04360__123 0.0349516848358576 UP 2.10928933028742 0.0401431636959514 Axon guidance: ENAH hsa04024__111 0.0354033066117065 UP 2.10408671389841 0.0406370269538159 cAMP signaling pathway: JUN hsa05212__10 0.0361891017303527 DOWN -2.09516794294582 0.0415136276870163 Pancreatic cancer: BCL2L1 hsa05217__4 0.0371246072120348 DOWN -2.0847627101678 0.0425607913065366 Basal cell carcinoma: PTCH1 hsa05161__30 0.0388463930944432 UP 2.06618193734991 0.0445075442832065 Hepatitis B: MYC hsa04726__72 0.041075195435192 DOWN -2.04314177905572 0.0470324754556525 Serotonergic synapse: KCNJ3 hsa04390__79 0.0418916788011942 UP 2.03496623901584 0.0479381635002704 Hippo signaling pathway: SNAI2 hsa04115__52 53 0.0442669234775452 DOWN -2.01192608072166 0.0506254103556344 p53 signaling pathway: CDK4 CCND1 hsa04630__28 0.0460207019949035 UP 1.99557500064191 0.0525990870124232 Jak-STAT signaling pathway: CCND1 hsa05142__53 0.0469193112180758 UP 1.98739946060203 0.053593547585875 Chagas disease (American trypanosomiasis): AKT3 hsa05223__7 0.0473326243643561 UP 1.98368330603846 0.0540328075216435 Non-small cell lung cancer: FOXO3 hsa05140__16 0.0474156533544273 UP 1.98294007512574 0.0540947253509222 Leishmaniasis: STAT1 hsa04115__54 0.0496177760183871 UP 1.96361607139513 0.0565726948656246 p53 signaling pathway: PERP hsa04913__35 0.0514584603319384 DOWN -1.9480082222281 0.0586358077402743 Ovarian steroidogenesis: HSD17B2 hsa04930__8 0.0525357056405819 UP 1.93908945127551 0.0598270247870627 Type II diabetes mellitus: C00022 hsa04910__57 0.0528989508465541 UP 1.93611652762464 0.060204196632753 Insulin signaling pathway: GCK hsa04350__12 0.053264292488947 UP 1.93314360397378 0.0605832963600069 TGF-beta signaling pathway: ACVR2A hsa05216__14 0.0549345109380894 UP 1.9197654475449 0.0624452184226679 Thyroid cancer: MAPK1* hsa04022__57 0.0552170823031359 UP 1.91753575480675 0.0627284749985443 cGMP-PKG signaling pathway: C00144 hsa04910__32 0.0583072534970201 DOWN -1.89375236559984 0.066198990526224 Insulin signaling pathway: EIF4E hsa04360__19 0.0604122389187908 UP 1.87814451643281 0.0685474619132898 Axon guidance: CDC42 hsa05134__70 0.06205798753114 UP 1.86625282182936 0.0703723346837731 Legionellosis: IL6 hsa04115__27 0.0632108234124088 UP 1.85807728178949 0.071636391551216 p53 signaling pathway: THBS1 hsa05220__25 0.064596026424442 DOWN -1.84841527992418 0.0731621058779545 Chronic myeloid leukemia: BCL2L1* hsa04933__52 0.0654608430510069 UP 1.84246943262245 0.0740969422246036 AGE-RAGE signaling pathway in diabetic complications: FOXO1 hsa05205__400 0.0662253477082648 UP 1.83726681623344 0.0749171754026668 Proteoglycans in cancer: ITGA2* hsa04072__27 0.0668865161748203 DOWN -1.83280743075715 0.0756195931964424 Phospholipase D signaling pathway: C01245 hsa05205__434 0.0684503454040961 DOWN -1.82240219797913 0.0773410697620545 Proteoglycans in cancer: CASP3 hsa04910__14 0.0715511723254646 UP 1.8023349633358 0.0807960653843437 Insulin signaling pathway: C00369 hsa04664__30 0.0721378438835723 UP 1.79861880877222 0.0814096148091486 Fc epsilon RI signaling pathway: PRKCA hsa05210__39 0.07308470780896 UP 1.7926729614705 0.0824286710522423 Colorectal cancer: BAD hsa04014__33 0.0740417161539813 DOWN -1.78672711416877 0.0834579392041577 Ras signaling pathway: BCL2L1 hsa05032__4 0.0769743529379095 UP 1.76888957226359 0.0867115162891678 Morphine addiction: ADCY1 hsa04115__34 0.07772211852141 UP 1.7644301867873 0.0874490183842691 p53 signaling pathway: ZMAT3 hsa04750__90 0.07772211852141 DOWN -1.7644301867873 0.0874490183842691 Inflammatory mediator regulation of TRP channels: C01245** hsa03320__56 0.0778473194202009 UP 1.76368695587458 0.0875213107477583 PPAR signaling pathway: FADS2 hsa04024__101 0.0779726845086468 DOWN -1.76294372496186 0.0875213107477583 cAMP signaling pathway: HCN4 hsa05200__199 0.0779726845086468 DOWN -1.76294372496186 0.0875213107477583 Pathways in cancer: BCL2L1** hsa05220__3 0.0779726845086468 DOWN -1.76294372496186 0.0875213107477583 Chronic myeloid leukemia: BCL2L1 hsa04390__78 0.0800009748629003 DOWN -1.75105203035841 0.089744377174561 Hippo signaling pathway: SOX2 hsa04720__32 0.0819412371189139 DOWN -1.73990356666767 0.0918661005647012 Long-term potentiation: ITPR1 hsa04115__29 0.0829915478258651 DOWN -1.73395771936595 0.0929881445228387 p53 signaling pathway: IGF1 hsa04072__3 0.0831236002825402 UP 1.73321448845323 0.0930805988861102 Phospholipase D signaling pathway: MAPK1 hsa04024__43 0.0856650978491568 UP 1.71909310111163 0.0958693977716294 cAMP signaling pathway: MAPK8 hsa04152__81 0.0896649429828134 DOWN -1.69753940464287 0.100285968967087 AMPK signaling pathway: LIPE hsa05166__99 0.0903695335717519 UP 1.6938232500793 0.101013892671815 HTLV-I infection: JUN hsa04360__21 0.0909364077675335 UP 1.69085032642843 0.101587104753386 Axon guidance: PAK4 hsa04010__129 0.096316605718938 UP 1.66335078265795 0.107533512861488 MAPK signaling pathway: FOS hsa05221__6 0.0981152418415663 DOWN -1.65443201170536 0.109476567351724 Acute myeloid leukemia: CEBPA hsa04310__34 0.10024745235876 UP 1.64402677892734 0.111789295538344 Wnt signaling pathway: FOSL1 hsa05034__99 0.108328765492094 DOWN -1.60612200237883 0.120729389299908 Alcoholism: PDYN hsa05213__27 0.119365965893849 DOWN -1.5578119930523 0.132951185485799 Endometrial cancer: ELK1 hsa05016__22 9 0.119542406426804 DOWN -1.55706876213959 0.133068828007088 Huntington's disease: DLG4 HTT hsa04360__6 0.120961295600042 UP 1.55112291483786 0.134568546141195 Axon guidance: MAPK1 hsa04360__125 0.124748595357385 UP 1.53551506567083 0.13869976963108 Axon guidance: ENAH* hsa04913__36 0.130886103457496 UP 1.51098844555121 0.145351647988555 Ovarian steroidogenesis: CYP19A1 hsa04913__37 0.130886103457496 UP 1.51098844555121 0.145351647988555 Ovarian steroidogenesis: CYP19A1* hsa05166__60 0.13240868684864 DOWN -1.50504259824948 0.146955654216535 HTLV-I infection: POLD3 hsa05219__27 0.135689693034536 DOWN -1.49240767273331 0.150508225036537 Bladder cancer: RPS6KA5 hsa04024__110 0.137451933120142 DOWN -1.48571859451887 0.152372968927874 cAMP signaling pathway: FOS hsa04213__52 0.138043252013207 UP 1.48348890178073 0.152938249134915 Longevity regulating pathway - multiple species: SOD2 hsa05218__14 0.139430619228878 UP 1.47828628539171 0.15438428611141 Melanoma: BAD hsa04722__34 0.140228205572627 DOWN -1.47531336174085 0.155175970713172 Neurotrophin signaling pathway: GSK3B hsa04932__96 0.140428149491127 UP 1.47457013082814 0.15530576391632 Non-alcoholic fatty liver disease (NAFLD): IL6* hsa04270__17 0.142439665619728 UP 1.46713782170098 0.1574377245291 Vascular smooth muscle contraction: ITPR1 hsa05152__90 0.145909888547183 UP 1.45450289618481 0.161083857664651 Tuberculosis: CR1 hsa04115__64 0.145909912583947 UP 1.45450289618481 0.161083857664651 p53 signaling pathway: PMAIP1 hsa05220__4 0.146528970955293 DOWN -1.45227320344666 0.161672305593068 Chronic myeloid leukemia: PTPN11 hsa04920__1 0.150074984438278 UP 1.43963827793049 0.16548761488235 Adipocytokine signaling pathway: C00195 hsa04064__134 0.150707489115214 DOWN -1.43740858519235 0.166087608238995 NF-kappa B signaling pathway: CCL21 hsa04920__3 0.15454526177201 UP 1.42403042876346 0.170117484985124 Adipocytokine signaling pathway: C15493 hsa05132__6 0.15454526177201 DOWN -1.42403042876346 0.170117484985124 Salmonella infection: NFKB1 hsa04110__96 97 0.155840882739049 DOWN -1.41957104328717 0.171443219359879 Cell cycle: TFDP1 E2F4 hsa04910__20 0.156491776207614 DOWN -1.41734135054902 0.172058541541315 Insulin signaling pathway: PKLR hsa04950__21 0.158456827779616 DOWN -1.41065227233458 0.174117180934443 Maturity onset diabetes of the young: PKLR hsa04713__14 0.16401329744474 DOWN -1.39207149951668 0.180117466919151 Circadian entrainment: PRKCA hsa04923__16 0.167645710455609 UP 1.38017980491323 0.183999001136735 Regulation of lipolysis in adipocytes: PLIN1 hsa03320__47 0.171571003468804 DOWN -1.36754487939706 0.188197265334432 PPAR signaling pathway: PLTP hsa04728__74 0.174147309957032 UP 1.35936933935719 0.190911782619173 Dopaminergic synapse: GRIN2A hsa04068__72 0.174618817477739 DOWN -1.35788287753176 0.191317060082024 FoxO signaling pathway: SMAD2 hsa04390__89 0.1767524000466 DOWN -1.35119379931731 0.193541817999744 Hippo signaling pathway: ID2 hsa04913__19 0.18474181572091 DOWN -1.32666717919769 0.202172319009662 Ovarian steroidogenesis: STAR hsa04015__18 0.187214832614425 DOWN -1.31923487007053 0.204640296964808 Rap1 signaling pathway: CDH1 hsa04360__131 0.187214832614425 UP 1.31923487007053 0.204640296964808 Axon guidance: RAC1**** hsa05211__31 0.190214617091055 UP 1.31031609911795 0.207798410182612 Renal cell carcinoma: SOS1 hsa03320__32 0.200992579386621 DOWN -1.27910040078388 0.219445122990971 PPAR signaling pathway: FABP3 hsa04520__44 52 45 0.205479480659346 DOWN -1.26646547526771 0.224213672566151 Adherens junction: ACTB ACTN4 CTNNA1 hsa04727__26 0.207348033514039 DOWN -1.2612628588787 0.225728247377103 GABAergic synapse: KCNJ6 hsa05032__81 0.207348033514039 DOWN -1.2612628588787 0.225728247377103 Morphine addiction: KCNJ6 hsa05032__91 0.207348033514039 DOWN -1.2612628588787 0.225728247377103 Morphine addiction: KCNJ6** hsa05032__85 0.207348033514039 DOWN -1.2612628588787 0.225728247377103 Morphine addiction: KCNJ6* hsa05142__29 0.207615972844331 UP 1.26051962796599 0.225889063679501 Chagas disease (American trypanosomiasis): NOS2 hsa05205__215 216 0.208152604785129 DOWN -1.25903316614056 0.226341865967162 Proteoglycans in cancer: EIF4B RPS6 hsa04152__44 0.209768533086121 DOWN -1.25457378066426 0.227967075574795 AMPK signaling pathway: SLC2A4 hsa04022__49 0.211393524533421 DOWN -1.25011439518797 0.229600250056819 cGMP-PKG signaling pathway: ATP1B4 hsa04911__24 0.21742966027357 UP 1.23376331510822 0.236019833422321 Insulin secretion: INS hsa04932__14 0.219097184624617 DOWN -1.22930392963192 0.237692615421279 Non-alcoholic fatty liver disease (NAFLD): PKLR hsa04010__107 0.225859084733452 UP 1.21146638772674 0.244887028398243 MAPK signaling pathway: MAP3K2 hsa05016__60 0.232187186057545 DOWN -1.195115307647 0.251458053372984 Huntington's disease: CASP3* hsa05134__35 0.232187186057545 DOWN -1.195115307647 0.251458053372984 Legionellosis: CASP3 hsa03320__40 0.234519226305985 DOWN -1.18916946034527 0.25383734229778 PPAR signaling pathway: FABP4 hsa05200__5 0.241316103733419 DOWN -1.17207514935281 0.260893532172091 Pathways in cancer: CASP3* hsa05210__7 0.241316103733419 DOWN -1.17207514935281 0.260893532172091 Colorectal cancer: CASP3* hsa05205__121 0.251615752469592 UP 1.14680529832047 0.271872339787443 Proteoglycans in cancer: PLAUR hsa04919__101 0.252539048733852 UP 1.14457560558232 0.272713145155694 Thyroid hormone signaling pathway: NOTCH1 hsa05200__53 0.253773779506025 DOWN -1.14160268193146 0.273889104934992 Pathways in cancer: BCL2L1 hsa04310__14 0.259068239369336 DOWN -1.12896775641529 0.279442722029267 Wnt signaling pathway: PRKCA hsa05205__256 0.259382043857987 UP 1.12822452550258 0.279620688702901 Proteoglycans in cancer: ACTB hsa04910__12 0.260325036462881 DOWN -1.12599483276443 0.280476343757886 Insulin signaling pathway: FASN hsa05161__207 0.26063989386683 UP 1.12525160185171 0.280493906400786 Hepatitis B: CDK2 hsa05161__219 0.26063989386683 UP 1.12525160185171 0.280493906400786 Hepatitis B: CDK2* hsa05205__431 0.270531311847755 DOWN -1.10221144355752 0.29097214365308 Proteoglycans in cancer: CDKN1A* hsa04520__4 0.280677042094396 DOWN -1.07917128526333 0.301711763212455 Adherens junction: CTNND1 hsa04920__37 0.282670196061713 DOWN -1.07471189978704 0.303680559405351 Adipocytokine signaling pathway: IRS1 hsa04310__32 0.288707112759413 UP 1.06133374335815 0.309988951357107 Wnt signaling pathway: PPARD hsa04062__59 0.294487880812839 DOWN -1.04869881784199 0.316015264447358 Chemokine signaling pathway: FOXO3 hsa04270__24 0.296546549893421 UP 1.04423943236569 0.318042789526106 Vascular smooth muscle contraction: ACTA2 hsa05030__77 0.298614824420522 UP 1.0397800468894 0.320078297253942 Cocaine addiction: BDNF hsa04213__53 0.302083303398973 DOWN -1.03234773776224 0.323611474963894 Longevity regulating pathway - multiple species: SOD1 hsa05133__73 0.303129054062271 DOWN -1.03011804502409 0.324546719420517 Pertussis: FOS hsa04621__21 30 0.304527127608607 UP 1.02714512137323 0.325857900214449 NOD-like receptor signaling pathway: NLRP3 PYCARD hsa05134__59 0.314791018518715 DOWN -1.00559142490447 0.336649017527983 Legionellosis: HSPA1A hsa04742__27 0.318743022344704 UP 0.997415884864596 0.340681535259214 Taste transduction: CALHM1 hsa04925__34 0.324549131847566 DOWN -0.985524190261143 0.346690061820112 Aldosterone synthesis and secretion: STAR hsa04024__59 0.329685603213847 UP 0.975118957483122 0.351976845703874 cAMP signaling pathway: MLLT4 hsa04350__21 0.33561997006165 DOWN -0.963227262879669 0.358108985659194 TGF-beta signaling pathway: CDKN2B hsa04971__56 0.337862979451762 DOWN -0.958767877403375 0.360297694886414 Gastric acid secretion: CAMK2A hsa05221__27 0.342000111576536 UP 0.950592337363501 0.364502671385315 Acute myeloid leukemia: PIM2 hsa04360__20 0.348839546448776 UP 0.937214180934617 0.371581353615221 Axon guidance: ROCK1 hsa04520__9 57 0.353447100624397 UP 0.928295409982027 0.376275978511752 Adherens junction: LEF1 CTNNB1 hsa04622__44 0.373455674366575 UP 0.890390633433522 0.397351762250733 RIG-I-like receptor signaling pathway: MAPK8 hsa04022__50 0.38758462966696 UP 0.864377551488469 0.412151397365149 cGMP-PKG signaling pathway: ATP2B1 hsa04068__50 0.403288154613543 UP 0.836134776805269 0.428607716356814 FoxO signaling pathway: TNFSF10 hsa04360__101 103 0.40370648683442 DOWN -0.835391545892553 0.428809773183649 Axon guidance: DPYSL2 DPYSL5 hsa04310__20 0.422369165649619 DOWN -0.802689385733058 0.448379470200924 Wnt signaling pathway: MAPK8 hsa05200__201 0.424952675429425 DOWN -0.798230000256763 0.45086735015917 Pathways in cancer: PDGFB hsa05200__76 0.42668013220616 DOWN -0.7952570766059 0.452444677435313 Pathways in cancer: RAC1 hsa04330__12 0.432758378908209 UP 0.784851843827879 0.458631130269896 Notch signaling pathway: HES1 hsa05211__40 0.436692146011153 DOWN -0.778162765613437 0.462539200876525 Renal cell carcinoma: PAK4 hsa04152__94 0.437130499156087 DOWN -0.777419534700721 0.462742652346077 AMPK signaling pathway: MLYCD hsa04211__23 0.43756910553448 DOWN -0.776676303788005 0.462946142623473 Longevity regulating pathway - mammal: SOD2 hsa04068__58 0.438447077606783 DOWN -0.775189841962573 0.463613989208298 FoxO signaling pathway: KLF2 hsa05034__62 0.448171373698194 DOWN -0.758838761882826 0.473629927547192 Alcoholism: NPY hsa04022__39 0.451290968842568 DOWN -0.753636145493815 0.476658645562218 cGMP-PKG signaling pathway: KCNJ8 hsa04911__56 0.453079096763162 UP 0.750663221842952 0.478278439785382 Insulin secretion: CAMK2A* hsa04024__118 0.45936894328715 UP 0.740257989064931 0.484645841907105 cAMP signaling pathway: MYL9 hsa04621__30 32 0.515241025732565 DOWN -0.651070279539036 0.543287254405999 NOD-like receptor signaling pathway: PYCARD CASP1 hsa05162__25 70 0.529740799679883 DOWN -0.628773352157562 0.558263018843802 Measles: IFNAR1 GNB2L1 hsa04610__7 0.544938774178452 UP 0.605733193863372 0.573957374821363 Complement and coagulation cascades: C00290 hsa05030__73 0.557850264746277 DOWN -0.586409190132762 0.587227253478014 Cocaine addiction: NFKB1 hsa04913__12 0.58360072148313 UP 0.548504413584256 0.61398978480784 Ovarian steroidogenesis: HSD3B1 hsa04550__25 0.586154795205125 UP 0.544788259020677 0.616331762837397 Signaling pathways regulating pluripotency of stem cells: MAPK1 hsa04722__46 0.586666231440478 UP 0.544045028107961 0.616524523980234 Neurotrophin signaling pathway: ATF4* hsa04152__15 0.58717787437612 DOWN -0.543301797195246 0.616717286725952 AMPK signaling pathway: FOXO1 hsa04810__30 0.5928195316949 UP 0.535126257155372 0.622294916231685 Regulation of actin cytoskeleton: VCL* hsa05162__27 70 0.611975839839868 UP 0.507626713384888 0.642045004499783 Measles: STAT1 GNB2L1 hsa04750__39 0.612497361067498 DOWN -0.506883482472172 0.642233561074681 Inflammatory mediator regulation of TRP channels: C01245* hsa04068__44 0.615630604613872 DOWN -0.502424096995877 0.645158899090611 FoxO signaling pathway: CDKN1B hsa05164__68 0.616153495894038 DOWN -0.501680866083161 0.645346944696153 Influenza A: EIF2S1 hsa04390__17 51 0.618247007444665 DOWN -0.498707942432298 0.647178900829262 Hippo signaling pathway: YWHAQ YAP1 hsa04213__2 0.624020126503151 UP 0.490532402392424 0.652858473106582 Longevity regulating pathway - multiple species: RPS6KB1 hsa04022__37 38 0.627178889867618 UP 0.486073016916129 0.655433333738184 cGMP-PKG signaling pathway: ATP2A1 PLN hsa04152__61 0.627178889867618 UP 0.486073016916129 0.655433333738184 AMPK signaling pathway: RPS6KB1 hsa05032__13 0.627706017607522 DOWN -0.485329786003414 0.655619570363832 Morphine addiction: PRKACA hsa04115__3 0.628760842954441 DOWN -0.483843324177982 0.656356457728553 p53 signaling pathway: GADD45G hsa04010__119 0.63722659495917 DOWN -0.471951629574529 0.664086950598048 MAPK signaling pathway: NFATC3 hsa04071__11 0.63722659495917 UP 0.471951629574529 0.664086950598048 Sphingolipid signaling pathway: PRKCA hsa04976__34 0.63722659495917 UP 0.471951629574529 0.664086950598048 Bile secretion: SLCO1B1 hsa04970__27 0.64200956184232 UP 0.465262551360087 0.668700646730443 Salivary secretion: PRKCA hsa05014__54 0.646807425372959 DOWN -0.458573473145645 0.673324738102931 Amyotrophic lateral sclerosis (ALS): PPP3CA hsa04213__54 0.666684836119077 UP 0.431073929375161 0.693632783536958 Longevity regulating pathway - multiple species: SOD2* hsa05012__70 0.670472442059368 UP 0.42587131298615 0.697187448051772 Parkinson's disease: PRKACA hsa04270__65 0.67372558134628 DOWN -0.421411927509855 0.699795736828987 Vascular smooth muscle contraction: NPR2 hsa04151__32 0.673725645515507 UP 0.421411927509855 0.699795736828987 PI3K-Akt signaling pathway: BCL2L1 hsa04724__3 0.681885285378087 UP 0.410263463819118 0.707879807306865 Glutamatergic synapse: GRIK1 hsa04972__39 0.682430599499575 UP 0.409520232906403 0.708054719193651 Pancreatic secretion: KCNMA1* hsa04024__31 0.683521725044028 DOWN -0.408033771080971 0.708404479513363 cAMP signaling pathway: C00165 hsa04024__32 0.683521725044028 DOWN -0.408033771080971 0.708404479513363 cAMP signaling pathway: C01245 hsa04950__8 0.686799061986836 DOWN -0.403574385604676 0.711408730690885 Maturity onset diabetes of the young: NEUROD1 hsa05145__9 0.687892821014071 UP 0.402087923779245 0.712149096796385 Toxoplasmosis: MAPK1 hsa05132__13 0.696116697680539 DOWN -0.390939460088508 0.720266120562628 Salmonella infection: FOS hsa04520__64 0.700517494094097 UP 0.384993612786781 0.724420677712057 Adherens junction: CTNND1** hsa05205__415 0.724341049949562 UP 0.353034683540002 0.748645122582634 Proteoglycans in cancer: MAPK1****** hsa05161__45 0.727687222318617 DOWN -0.348575298063708 0.751690099360462 Hepatitis B: PCNA hsa04915__28 0.729920896334715 DOWN -0.345602374412844 0.753583167149961 Estrogen signaling pathway: KCNJ3 hsa05160__53 0.747871390349055 UP 0.321818985205939 0.771268025502675 Hepatitis C: EIF2S1 hsa05162__74 0.747871390349055 UP 0.321818985205939 0.771268025502675 Measles: EIF2S1 hsa04921__67 0.759160984104124 UP 0.306954366951623 0.782481343462232 Oxytocin signaling pathway: RYR1 hsa05012__57 0.767094516505738 UP 0.296549134173602 0.790225107738093 Parkinson's disease: CASP3 hsa04670__76 0.767662143691917 UP 0.295805903260886 0.790376530409376 Leukocyte transendothelial migration: CDC42 hsa04933__19 0.776191348895858 UP 0.284657439570149 0.798720451574654 AGE-RAGE signaling pathway in diabetic complications: TGFBR2 hsa04630__30 0.782463362052957 DOWN -0.276481899530275 0.804733802571159 Jak-STAT signaling pathway: CDKN1A hsa04270__10 3 71 0.786462047523568 DOWN -0.271279283141265 0.80840382237242 Vascular smooth muscle contraction: ACTA2 MYL9 MYH11 hsa04710__11 0.791038873821765 DOWN -0.265333435839539 0.812663774691687 Circadian rhythm: CRY1 hsa05212__31 0.808840864691841 UP 0.242293277545349 0.830498352325666 Pancreatic cancer: RAC1* hsa04919__38 0.827900494748724 UP 0.217766657425728 0.849604057691345 Thyroid hormone signaling pathway: TP53 hsa04933__63 0.828479705163547 DOWN -0.217023426513012 0.849734370088595 AGE-RAGE signaling pathway in diabetic complications: SELE hsa04360__31 0.8302178948276 UP 0.214793733774865 0.85105260468143 Axon guidance: CDC42* hsa04064__55 0.83950207650833 DOWN -0.202902039171412 0.860100546215459 NF-kappa B signaling pathway: CXCL12 hsa05014__13 0.840083094262368 UP 0.202158808258696 0.860226776086642 Amyotrophic lateral sclerosis (ALS): CASP3 hsa04211__52 0.85521924025974 DOWN -0.182834804528085 0.875248884775627 Longevity regulating pathway - mammal: PPARG hsa05211__48 0.856969262727748 UP 0.180605111789938 0.876562463073184 Renal cell carcinoma: JUN hsa04068__42 0.859303718762769 DOWN -0.177632188139075 0.878472082456606 FoxO signaling pathway: CDKN2D hsa04972__51 0.859887525824312 DOWN -0.176888957226359 0.878590897783514 Pancreatic secretion: CLCA1 hsa04727__47 0.862223516909661 UP 0.173916033575496 0.880498906670246 GABAergic synapse: CACNA1A* hsa04950__18 0.86514519869175 UP 0.170199879011917 0.883002622673437 Maturity onset diabetes of the young: SLC2A2 hsa04024__116 0.872750105520688 DOWN -0.160537877146612 0.890280916543633 cAMP signaling pathway: ACOX1 hsa04730__7 0.874506781823752 DOWN -0.158308184408464 0.891588845928828 Long-term depression: GNA13 hsa04915__21 0.875678243619562 DOWN -0.156821722583033 0.892299034577634 Estrogen signaling pathway: CREB3 hsa04933__21 0.902691933517202 UP 0.122633100598106 0.91932690681779 AGE-RAGE signaling pathway in diabetic complications: SMAD4 hsa04921__57 0.905635579679295 DOWN -0.118916946034527 0.921825164798156 Oxytocin signaling pathway: FOS hsa05031__96 0.906224465841454 UP 0.118173715121811 0.921925160431019 Amphetamine addiction: PDYN hsa04370__38 0.907991432414627 DOWN -0.115944022383664 0.923222890425911 VEGF signaling pathway: BAD hsa04261__3 0.928637408423911 DOWN -0.0899309404386111 0.943704537819648 Adrenergic signaling in cardiomyocytes: RYR2 hsa04022__44 0.932181938401271 UP 0.0854715549623163 0.946794520138372 cGMP-PKG signaling pathway: BAD hsa04932__28 0.936318918868262 UP 0.0802689385733058 0.950482576203924 Non-alcoholic fatty liver disease (NAFLD): GSK3A hsa05034__84 0.939274964463674 UP 0.0765527840097268 0.952968497962874 Alcoholism: FOSB hsa03320__66 0.941048996168033 UP 0.0743230912715794 0.954253137506602 PPAR signaling pathway: UCP1 hsa04022__45 0.944597928429753 DOWN -0.0698637057952847 0.957335225199302 cGMP-PKG signaling pathway: CREB3 hsa05231__17 0.946964498693422 UP 0.0668907821444215 0.959216330482447 Choline metabolism in cancer: SLC44A3 hsa05205__129 0.972430408469829 UP 0.0349318528976423 0.983950854881426 Proteoglycans in cancer: AKT3* hsa05211__46 0.972430408469829 UP 0.0349318528976423 0.983950854881426 Renal cell carcinoma: AKT3 hsa04921__33 0.999703493771641 DOWN -0.000743230912715794 1 Oxytocin signaling pathway: C00942 hsa04152__33 1 0 0 1 AMPK signaling pathway: CPT1C hsa04152__41 1 0 0 1 AMPK signaling pathway: FBP1 hsa04211__2 1 0 0 1 Longevity regulating pathway - mammal: RPS6KB1 hsa04911__41 1 0 0 1 Insulin secretion: ABCC8 hsa04911__35 1 0 0 1 Insulin secretion: TRPM4 hsa04922__67 1 0 0 1 Glucagon signaling pathway: FBP1 hsa04922__60 1 0 0 1 Glucagon signaling pathway: CPT1C* hsa04924__34 1 0 0 1 Renin secretion: REN hsa04924__47 1 0 0 1 Renin secretion: KCNMA1 hsa04931__151 1 0 0 1 Insulin resistance: CPT1A hsa04931__29 1 0 0 1 Insulin resistance: CPT1B hsa04960__15 1 0 0 1 Aldosterone-regulated sodium reabsorption: C00762 hsa05030__13 1 0 0 1 Cocaine addiction: SLC6A3 hsa05031__15 1 0 0 1 Amphetamine addiction: MAOA hsa05031__77 1 0 0 1 Amphetamine addiction: MAOA* hsa05034__7 1 0 0 1 Alcoholism: GRIN3A hsa05034__75 1 0 0 1 Alcoholism: SLC29A1 hsa05140__37 1 0 0 1 Leishmaniasis: ELK1 hsa05140__55 1 0 0 1 Leishmaniasis: JUN hsa05140__41 57 1 0 0 1 Leishmaniasis: NOS2 CYBA hsa05211__12 1 0 0 1 Renal cell carcinoma: EGLN2