15 inhibition.up 11 16 activation.up 11 3 4 activation.up 11 10 8 9 inhibition.up 3 4 10 8 9 inhibition 3 4 17 activation 7 18 activation 7 20 activation 17 21 activation 17 3 4 activation 7 12 13 inhibition 7 3 4 activation.up 23 3 4 activation.up 5 11 activation 11_func 7 activation 7_func 23 activation 23_func 5 activation 5_func