p.value	UP.DOWN	statistic	FDRp.value	path.name
hsa05169__11	1.50101591980642e-26	UP	9.08563779835124	2.82040891331626e-23	Epstein-Barr virus infection: HLA-A
hsa04961__20	2.58766479240442e-21	DOWN	-9.4695054172177	4.11195512649443e-19	Endocrine and other factor-regulated calcium reabsorption: CALB1*
hsa04670__15	2.85822764030966e-21	UP	9.4695054172177	4.11195512649443e-19	Leukocyte transendothelial migration: PECAM1
hsa04550__101	2.87464712442029e-21	DOWN	-9.4695054172177	4.11195512649443e-19	Signaling pathways regulating pluripotency of stem cells: ESRRB
hsa04950__20	2.87464712442029e-21	DOWN	-9.4695054172177	4.11195512649443e-19	Maturity onset diabetes of the young: NKX6-1
hsa04960__13	2.87464712442029e-21	DOWN	-9.4695054172177	4.11195512649443e-19	Aldosterone-regulated sodium reabsorption: FXYD4
hsa04962__10	2.87464712442029e-21	DOWN	-9.4695054172177	4.11195512649443e-19	Vasopressin-regulated water reabsorption: AQP2
hsa04976__41	2.87464712442029e-21	UP	9.4695054172177	4.11195512649443e-19	Bile secretion: CYP7A1
hsa04976__36	2.87464712442029e-21	UP	9.4695054172177	4.11195512649443e-19	Bile secretion: SLC10A1
hsa05200__168	2.87464712442029e-21	UP	9.4695054172177	4.11195512649443e-19	Pathways in cancer: E2F1
hsa05212__34	2.87464712442029e-21	UP	9.4695054172177	4.11195512649443e-19	Pancreatic cancer: E2F1
hsa05214__35	2.87464712442029e-21	UP	9.4695054172177	4.11195512649443e-19	Glioma: E2F1
hsa04066__30	3.14059982855692e-21	UP	9.46025559507634	4.11195512649443e-19	HIF-1 signaling pathway: PDK1
hsa04950__13	3.14059982855692e-21	DOWN	-9.46025559507634	4.11195512649443e-19	Maturity onset diabetes of the young: INS
hsa05166__120	3.28256130374755e-21	UP	9.45563068400566	4.11195512649443e-19	HTLV-I infection: E2F1
hsa04917__34	3.74764480978776e-21	DOWN	-9.44175595079362	4.27297604437857e-19	Prolactin signaling pathway: ELF5
hsa04930__26	3.91671434707515e-21	DOWN	-9.43713103972294	4.27297604437857e-19	Type II diabetes mellitus: INS*
hsa04066__37	4.0933245768395e-21	DOWN	-9.43250612865226	4.27297604437857e-19	HIF-1 signaling pathway: PDHA1
hsa04530__20 37	4.47051109571419e-21	DOWN	-9.4232563065109	4.35519710326534e-19	Tight junction: ACTB TJP3
hsa04933__57	4.8820408168809e-21	UP	9.41400648436954	4.35519710326534e-19	AGE-RAGE signaling pathway in diabetic complications: FIGF
hsa03320__41	5.10163911549143e-21	UP	9.40938157329886	4.35519710326534e-19	PPAR signaling pathway: ANGPTL4
hsa04961__17	5.3310023084142e-21	DOWN	-9.40475666222818	4.35519710326534e-19	Endocrine and other factor-regulated calcium reabsorption: CALB1
hsa05169__31	5.3310023084142e-21	UP	9.40475666222818	4.35519710326534e-19	Epstein-Barr virus infection: MYC
hsa05150__48	5.5705594878238e-21	UP	9.4001317511575	4.36128386567539e-19	Staphylococcus aureus infection: C3AR1
hsa04210__64	6.93762282234711e-21	UP	9.37700719580409	5.17726360102875e-19	Apoptosis: TNFRSF10D*
hsa04750__44	7.57305479141257e-21	UP	9.36775737366273	5.17726360102875e-19	Inflammatory mediator regulation of TRP channels: TRPA1
hsa04750__63	7.57305479141257e-21	UP	9.36775737366273	5.17726360102875e-19	Inflammatory mediator regulation of TRP channels: TRPA1*
hsa04960__3	7.91202262886693e-21	DOWN	-9.36313246259205	5.17726360102875e-19	Aldosterone-regulated sodium reabsorption: SCNN1A
hsa04931__13	8.26598765464942e-21	DOWN	-9.35850755152137	5.17726360102875e-19	Insulin resistance: AKT2
hsa05219__12	8.26598765464942e-21	DOWN	-9.35850755152137	5.17726360102875e-19	Bladder cancer: ERBB2
hsa04115__21	9.42456485808703e-21	UP	9.34463281830933	5.71250237688565e-19	p53 signaling pathway: DDB2
hsa04210__60	9.8453640516757e-21	UP	9.34000790723865	5.78107470409332e-19	Apoptosis: BBC3
hsa04390__90	1.02847339622369e-20	UP	9.33538299616797	5.85606518637671e-19	Hippo signaling pathway: BBC3
hsa04933__78	1.45731188404608e-20	UP	9.29838370760253	8.05379126506641e-19	AGE-RAGE signaling pathway in diabetic complications: TGFB1
hsa04014__70	1.58964620552782e-20	UP	9.28913388546117	8.07282491942371e-19	Ras signaling pathway: RIN1*
hsa04115__38	1.58964620552782e-20	UP	9.28913388546117	8.07282491942371e-19	p53 signaling pathway: GTSE1
hsa04151__27	1.58964620552782e-20	UP	9.28913388546117	8.07282491942371e-19	PI3K-Akt signaling pathway: FASLG
hsa04010__118	1.73385068565314e-20	UP	9.27988406331981	8.57343536405854e-19	MAPK signaling pathway: JUN
hsa04916__7	1.8107292630899e-20	DOWN	-9.27525915224913	8.72400073165621e-19	Melanogenesis: TYRP1
hsa04960__27	2.15342098465704e-20	DOWN	-9.25675950796641	9.60282312215313e-19	Aldosterone-regulated sodium reabsorption: KCNJ1
hsa05223__28	2.15342098465704e-20	UP	9.25675950796641	9.60282312215313e-19	Non-small cell lung cancer: RB1
hsa04917__40	2.24866533994006e-20	DOWN	-9.25213459689573	9.60282312215313e-19	Prolactin signaling pathway: TH
hsa04976__37	2.24866533994006e-20	UP	9.25213459689573	9.60282312215313e-19	Bile secretion: ABCB11
hsa05200__219	2.24866533994006e-20	UP	9.25213459689573	9.60282312215313e-19	Pathways in cancer: MYC**
hsa04933__29	2.34807261281105e-20	UP	9.24750968582505	9.80450764327102e-19	AGE-RAGE signaling pathway in diabetic complications: ICAM1
hsa05014__51	2.67310789461469e-20	UP	9.23363495261301	1.06867441148532e-18	Amyotrophic lateral sclerosis (ALS): DERL1
hsa05200__66	2.67310789461469e-20	UP	9.23363495261301	1.06867441148532e-18	Pathways in cancer: CCND1
hsa04014__27	2.79104240755725e-20	UP	9.22901004154233	1.0702793232245e-18	Ras signaling pathway: ABL1
hsa05169__32	2.79104240755725e-20	DOWN	-9.22901004154233	1.0702793232245e-18	Epstein-Barr virus infection: CR2
hsa04921__76	3.04255730544446e-20	UP	9.21976021940097	1.14339303538603e-18	Oxytocin signaling pathway: CDKN1A
hsa04115__49	3.17658990696714e-20	UP	9.21513530833029	1.14784854522909e-18	p53 signaling pathway: MDM2*
hsa04151__2	3.17658990696714e-20	DOWN	-9.21513530833029	1.14784854522909e-18	PI3K-Akt signaling pathway: EIF4E
hsa05218__21	4.48135660222561e-20	UP	9.17813601976485	1.55934612140406e-18	Melanoma: RB1
hsa05220__40	4.48135660222561e-20	UP	9.17813601976485	1.55934612140406e-18	Chronic myeloid leukemia: RB1
hsa04115__24	4.67788142107454e-20	DOWN	-9.17351110869416	1.59813439821801e-18	p53 signaling pathway: SERPINB5
hsa04012__40	4.88292132848494e-20	UP	9.16888619762348	1.63839449575414e-18	ErbB signaling pathway: ELK1*
hsa04950__1	5.0777747132494e-20	UP	9.1642612865528	1.67388398003432e-18	Maturity onset diabetes of the young: HNF1B
hsa05152__88 89	5.32001927496073e-20	UP	9.15963637548212	1.72350279614676e-18	Tuberculosis: ITGAX ITGB2
hsa04115__37	6.3134963362295e-20	UP	9.1411367311994	1.9048008400305e-18	p53 signaling pathway: FAS
hsa04340__49	6.3134963362295e-20	UP	9.1411367311994	1.9048008400305e-18	Hedgehog signaling pathway: CCND1
hsa04650__110 111	6.3134963362295e-20	UP	9.1411367311994	1.9048008400305e-18	Natural killer cell mediated cytotoxicity: ITGAL ITGB2
hsa05200__209	6.3134963362295e-20	UP	9.1411367311994	1.9048008400305e-18	Pathways in cancer: FIGF**
hsa04066__53	6.58925250675798e-20	DOWN	-9.13651182012872	1.9048008400305e-18	HIF-1 signaling pathway: EGF*
hsa04110__59 15 16 17 18 19 20	6.58925250675798e-20	UP	9.13651182012872	1.9048008400305e-18	Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
hsa04621__29	6.58925250675798e-20	UP	9.13651182012872	1.9048008400305e-18	NOD-like receptor signaling pathway: CASP5
hsa03320__44	6.87690749933958e-20	DOWN	-9.13188690905804	1.95783472594834e-18	PPAR signaling pathway: FABP1
hsa04024__9 95	7.17696832740006e-20	UP	9.12726199798736	1.98316521870363e-18	cAMP signaling pathway: ATP1B4 FXYD1
hsa04360__117	7.17696832740006e-20	UP	9.12726199798736	1.98316521870363e-18	Axon guidance: CFL1*
hsa04210__102	7.48996332842327e-20	UP	9.12263708691668	2.03965812958077e-18	Apoptosis: PIDD1
hsa04014__45	7.81644304873299e-20	UP	9.118012175846	2.06860513923511e-18	Ras signaling pathway: RAB5A
hsa05133__27	7.81644304873299e-20	UP	9.118012175846	2.06860513923511e-18	Pertussis: IRF3
hsa04210__63	8.5121754402372e-20	UP	9.10876235370464	2.22144134058413e-18	Apoptosis: FAS*
hsa04360__122	8.88264872689279e-20	DOWN	-9.10413744263396	2.25547256186913e-18	Axon guidance: CFL1**
hsa05150__1 2 3	8.88264872689279e-20	UP	9.10413744263396	2.25547256186913e-18	Staphylococcus aureus infection: CFD C3 CFB
hsa04923__26 27	9.26812433061816e-20	DOWN	-9.09951253156328	2.26188895457684e-18	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5
hsa04115__2	9.26905000012863e-20	UP	9.09951253156328	2.26188895457684e-18	p53 signaling pathway: IGFBP3
hsa04210__56	9.26905000012863e-20	UP	9.09951253156328	2.26188895457684e-18	Apoptosis: BAX
hsa04012__24	1.098789062395e-19	UP	9.08101288728056	2.64695467723103e-18	ErbB signaling pathway: CDKN1A
hsa04012__8	1.14646590206977e-19	DOWN	-9.07638797620988	2.72684737973304e-18	ErbB signaling pathway: STAT5A
hsa05168__27	1.19618616009028e-19	UP	9.0717630651392	2.80954224351206e-18	Herpes simplex infection: IRF3
hsa05150__40	1.30210642777385e-19	UP	9.06251324299784	3.02056540467538e-18	Staphylococcus aureus infection: FCGR1A
hsa04211__29	1.35849036235647e-19	DOWN	-9.05788833192716	3.07542577212988e-18	Longevity regulating pathway - mammal: EIF4E
hsa05120__18	1.35849036235647e-19	UP	9.05788833192716	3.07542577212988e-18	Epithelial cell signaling in Helicobacter pylori infection: CCL5
hsa04066__11	1.41728586865989e-19	UP	9.05326342085648	3.17033350858564e-18	HIF-1 signaling pathway: SLC2A1
hsa03320__53	1.47859477952843e-19	UP	9.0486385097858	3.23055766364409e-18	PPAR signaling pathway: ADIPOQ
hsa04152__27	1.47859477952843e-19	UP	9.0486385097858	3.23055766364409e-18	AMPK signaling pathway: ADIPOR1
hsa05152__20	1.60886433090988e-19	UP	9.03938868764444	3.39736192021185e-18	Tuberculosis: FCGR1A
hsa04012__56	1.60918153751386e-19	UP	9.03938868764444	3.39736192021185e-18	ErbB signaling pathway: JUN
hsa04064__136	1.60918153751386e-19	UP	9.03938868764444	3.39736192021185e-18	NF-kappa B signaling pathway: TNFSF13B*
hsa04380__32	1.67868497174983e-19	UP	9.03476377657376	3.50472117990881e-18	Osteoclast differentiation: AKT3
hsa04920__28	1.82671155310518e-19	UP	9.0255139544324	3.77185825086223e-18	Adipocytokine signaling pathway: SLC2A1
hsa05200__212	1.90548962041381e-19	UP	9.02088904336172	3.89175543125822e-18	Pathways in cancer: CCND1***
hsa04933__22	1.9876230130344e-19	UP	9.01626413229104	4.015853377948e-18	AGE-RAGE signaling pathway in diabetic complications: EDN1
hsa04015__11	2.07325280978221e-19	UP	9.01163922122036	4.02315469881234e-18	Rap1 signaling pathway: RAC1
hsa04621__33 35	2.07325280978221e-19	UP	9.01163922122036	4.02315469881234e-18	NOD-like receptor signaling pathway: NLRC4 PYCARD
hsa04921__59	2.07325280978221e-19	UP	9.01163922122036	4.02315469881234e-18	Oxytocin signaling pathway: CCND1
hsa03320__21	2.16252594241643e-19	DOWN	-9.00701431014968	4.02315469881234e-18	PPAR signaling pathway: ACAA1
hsa04972__23	2.16252594241643e-19	UP	9.00701431014968	4.02315469881234e-18	Pancreatic secretion: KCNMA1
hsa05162__13	2.16252594241643e-19	UP	9.00701431014968	4.02315469881234e-18	Measles: IRF7
hsa05200__223	2.16252594241643e-19	UP	9.00701431014968	4.02315469881234e-18	Pathways in cancer: CCND1****
hsa05221__17	2.16252594241643e-19	UP	9.00701431014968	4.02315469881234e-18	Acute myeloid leukemia: CCND1
hsa04932__35	2.25559543510455e-19	UP	9.002389399079	4.15516061035435e-18	Non-alcoholic fatty liver disease (NAFLD): PRKAG2
hsa04650__116	2.35262065354342e-19	UP	8.99776448800832	4.25055212308471e-18	Natural killer cell mediated cytotoxicity: FCGR3A
hsa05152__24 25	2.35262065354342e-19	UP	8.99776448800832	4.25055212308471e-18	Tuberculosis: ITGB2 ITGAM
hsa04151__35	2.45376756411979e-19	UP	8.99313957693764	4.33221055639094e-18	PI3K-Akt signaling pathway: CCND1
hsa05162__78	2.45376756411979e-19	UP	8.99313957693764	4.33221055639094e-18	Measles: FAS
hsa04115__40	2.55920900350928e-19	UP	8.98851466586696	4.33221055639094e-18	p53 signaling pathway: PIDD1
hsa04210__58	2.55920900350928e-19	UP	8.98851466586696	4.33221055639094e-18	Apoptosis: BID*
hsa04650__39	2.55920900350928e-19	UP	8.98851466586696	4.33221055639094e-18	Natural killer cell mediated cytotoxicity: FAS
hsa04666__23	2.55920900350928e-19	UP	8.98851466586696	4.33221055639094e-18	Fc gamma R-mediated phagocytosis: RPS6KB1
hsa05164__23	2.55920900350928e-19	UP	8.98851466586696	4.33221055639094e-18	Influenza A: IRF3
hsa04210__61	2.6691249591279e-19	UP	8.98388975479628	4.36111808539246e-18	Apoptosis: APAF1
hsa05142__84	2.6691249591279e-19	UP	8.98388975479628	4.36111808539246e-18	Chagas disease (American trypanosomiasis): NFKB1*
hsa05200__224	2.6691249591279e-19	UP	8.98388975479628	4.36111808539246e-18	Pathways in cancer: MYC***
hsa05221__12	2.6691249591279e-19	UP	8.98388975479628	4.36111808539246e-18	Acute myeloid leukemia: MYC
hsa04620__23	2.78370286086617e-19	UP	8.9792648437256	4.50911868583408e-18	Toll-like receptor signaling pathway: CD40
hsa04390__18	2.90313788455306e-19	DOWN	-8.97463993265492	4.66238981630359e-18	Hippo signaling pathway: MOB1A
hsa04066__42	3.02763326761427e-19	UP	8.97001502158424	4.74076909153934e-18	HIF-1 signaling pathway: HK1
hsa04917__71	3.02763326761427e-19	UP	8.97001502158424	4.74076909153934e-18	Prolactin signaling pathway: CCND1*
hsa05166__65	3.02763326761427e-19	UP	8.97001502158424	4.74076909153934e-18	HTLV-I infection: PTTG2
hsa04210__10	3.2926603527338e-19	UP	8.96076519944288	5.07123672359574e-18	Apoptosis: BIRC2
hsa04972__51	3.2926603527338e-19	UP	8.96076519944288	5.07123672359574e-18	Pancreatic secretion: CLCA1
hsa04611__7	3.43364185905438e-19	UP	8.9561402883722	5.20307504287354e-18	Platelet activation: ITPR1
hsa04620__40	3.43364185905438e-19	UP	8.9561402883722	5.20307504287354e-18	Toll-like receptor signaling pathway: CCL5
hsa04970__28	3.73193296463217e-19	DOWN	-8.94689046623084	5.52416485354026e-18	Salivary secretion: AQP5
hsa04210__70	3.73373569132311e-19	UP	8.94689046623084	5.52416485354026e-18	Apoptosis: CFLAR*
hsa04919__44	3.73373569132311e-19	DOWN	-8.94689046623084	5.52416485354026e-18	Thyroid hormone signaling pathway: PFKFB2
hsa04012__29	3.89335574115016e-19	UP	8.94226555516016	5.67101971908617e-18	ErbB signaling pathway: STAT5A*
hsa05169__64	3.89335574115016e-19	UP	8.94226555516016	5.67101971908617e-18	Epstein-Barr virus infection: NFKB2
hsa04921__58	4.05971384500601e-19	UP	8.93764064408948	5.82305520211167e-18	Oxytocin signaling pathway: MEF2C
hsa05166__132 136	4.05971384500601e-19	UP	8.93764064408948	5.82305520211167e-18	HTLV-I infection: CREBBP TP53
hsa04210__72	4.23309072837819e-19	UP	8.9330157330188	5.93580408852434e-18	Apoptosis: BCL2A1
hsa04666__20	4.23309072837819e-19	DOWN	-8.9330157330188	5.93580408852434e-18	Fc gamma R-mediated phagocytosis: PLA2G4B
hsa04910__46	4.23309072837819e-19	DOWN	-8.9330157330188	5.93580408852434e-18	Insulin signaling pathway: FBP1
hsa04064__137	4.41377865419272e-19	UP	8.92839082194812	6.0981544788442e-18	NF-kappa B signaling pathway: ICAM1
hsa05110__17	4.41377865419272e-19	DOWN	-8.92839082194812	6.0981544788442e-18	Vibrio cholerae infection: C00698*
hsa04961__5	4.60208189030997e-19	DOWN	-8.92376591087744	6.17665133706603e-18	Endocrine and other factor-regulated calcium reabsorption: TRPV5
hsa05110__51	4.60208189030997e-19	UP	8.92376591087744	6.17665133706603e-18	Vibrio cholerae infection: PDIA4
hsa05150__13	4.60208189030997e-19	UP	8.92376591087744	6.17665133706603e-18	Staphylococcus aureus infection: C5AR1
hsa05321__75	4.60208189030997e-19	UP	8.92376591087744	6.17665133706603e-18	Inflammatory bowel disease (IBD): IL10
hsa04728__24	4.79831719568479e-19	UP	8.91914099980676	6.39435319907214e-18	Dopaminergic synapse: SLC6A3
hsa04066__89	5.0028143259254e-19	UP	8.91451608873607	6.61992121015058e-18	HIF-1 signaling pathway: CDKN1A
hsa05142__7	5.43746085015763e-19	UP	8.90526626659471	7.09581024560419e-18	Chagas disease (American trypanosomiasis): C1QA
hsa05162__101	5.43798124197447e-19	DOWN	-8.90526626659471	7.09581024560419e-18	Measles: CDKN1B
hsa04152__77	5.6693803593275e-19	UP	8.90064135552403	7.29641485970984e-18	AMPK signaling pathway: CCND1
hsa04925__5	5.6693803593275e-19	UP	8.90064135552403	7.29641485970984e-18	Aldosterone synthesis and secretion: KCNK3
hsa04012__23	6.1617465927056e-19	DOWN	-8.89139153338267	7.66749791238001e-18	ErbB signaling pathway: RPS6KB1
hsa04115__31	6.1617465927056e-19	UP	8.89139153338267	7.66749791238001e-18	p53 signaling pathway: ADGRB1
hsa04115__17	6.1617465927056e-19	UP	8.89139153338267	7.66749791238001e-18	p53 signaling pathway: TP73
hsa04742__47	6.1617465927056e-19	DOWN	-8.89139153338267	7.66749791238001e-18	Taste transduction: GABRA1
hsa05219__21	6.1617465927056e-19	UP	8.89139153338267	7.66749791238001e-18	Bladder cancer: RB1
hsa05145__29	6.69630694126847e-19	UP	8.88214171124131	8.22376519127023e-18	Toxoplasmosis: C06314
hsa05222__44	6.69630694126847e-19	UP	8.88214171124131	8.22376519127023e-18	Small cell lung cancer: RB1
hsa04620__22	6.98051302875515e-19	UP	8.87751680017063	8.51713245521489e-18	Toll-like receptor signaling pathway: CD86
hsa04621__34 35	7.27662764393628e-19	UP	8.87289188909995	8.82115054384275e-18	NOD-like receptor signaling pathway: CASP1 PYCARD
hsa04612__18	7.58514316723881e-19	UP	8.86826697802927	9.13620769951392e-18	Antigen processing and presentation: KIR2DS2
hsa04115__20	7.90657205775579e-19	UP	8.86364206695859	9.46270630351792e-18	p53 signaling pathway: RRM2B
hsa05215__39	8.24144766032018e-19	UP	8.85901715588791	9.80106338844406e-18	Prostate cancer: RB1
hsa04917__65	8.59032504453474e-19	DOWN	-8.85439224481723	1.01517111689816e-17	Prolactin signaling pathway: CYP17A1
hsa04933__59	8.95378187700595e-19	UP	8.84976733374655	1.05150975918089e-17	AGE-RAGE signaling pathway in diabetic complications: SERPINE1
hsa04961__26	9.33241932807254e-19	DOWN	-8.84514242267587	1.08916869052474e-17	Endocrine and other factor-regulated calcium reabsorption: TRPV5*
hsa04530__4 37 11	1.01377639786494e-18	DOWN	-8.83589260053451	1.16864162674124e-17	Tight junction: OCLN TJP3 TJP1
hsa04610__52	1.01377639786494e-18	UP	8.83589260053451	1.16864162674124e-17	Complement and coagulation cascades: CPB2
hsa04920__26	1.05657997082247e-18	UP	8.83126768946383	1.21055717388745e-17	Adipocytokine signaling pathway: NPY
hsa05223__14	1.10116751936741e-18	UP	8.82664277839315	1.25399622357053e-17	Non-small cell lung cancer: CCND1
hsa04012__22	1.14761240292342e-18	UP	8.82201786732247	1.29901428017657e-17	ErbB signaling pathway: EIF4EBP1
hsa05169__30	1.19599095565783e-18	UP	8.81739295625179	1.33765893195302e-17	Epstein-Barr virus infection: FGR
hsa05321__95	1.19599095565783e-18	UP	8.81739295625179	1.33765893195302e-17	Inflammatory bowel disease (IBD): SMAD2
hsa03320__63	1.24638260536414e-18	DOWN	-8.81276804518111	1.36956310846738e-17	PPAR signaling pathway: DBI
hsa04150__31	1.24638260536414e-18	DOWN	-8.81276804518111	1.36956310846738e-17	mTOR signaling pathway: EIF4E
hsa04917__47	1.24638260536414e-18	DOWN	-8.81276804518111	1.36956310846738e-17	Prolactin signaling pathway: INS
hsa04010__66	1.29886999702346e-18	UP	8.80814313411043	1.41073799098676e-17	MAPK signaling pathway: TP53
hsa04550__67	1.29886999702346e-18	UP	8.80814313411043	1.41073799098676e-17	Signaling pathways regulating pluripotency of stem cells: MYC*
hsa04530__8	1.35353912122681e-18	DOWN	-8.80351822303975	1.4450568231734e-17	Tight junction: LLGL2
hsa04970__45	1.35353912122681e-18	UP	8.80351822303975	1.4450568231734e-17	Salivary secretion: KCNMA1
hsa05321__83	1.35353912122681e-18	UP	8.80351822303975	1.4450568231734e-17	Inflammatory bowel disease (IBD): IL2
hsa04110__48	1.41047944764604e-18	UP	8.79889331196907	1.48060943135581e-17	Cell cycle: RB1*
hsa04620__87	1.41047944764604e-18	UP	8.79889331196907	1.48060943135581e-17	Toll-like receptor signaling pathway: CCL4L1
hsa04670__86	1.41047944764604e-18	UP	8.79889331196907	1.48060943135581e-17	Leukocyte transendothelial migration: ACTB
hsa04210__85	1.46978406374889e-18	UP	8.79426840089839	1.53429125321342e-17	Apoptosis: FASLG*
hsa04923__52 53	1.59587747448533e-18	DOWN	-8.78501857875703	1.64761196404282e-17	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5*
hsa05200__220	1.59587747448533e-18	UP	8.78501857875703	1.64761196404282e-17	Pathways in cancer: CSF1R*
hsa03460__7	1.66287185899712e-18	UP	8.78039366768635	1.68893849894897e-17	Fanconi anemia pathway: FANCI
hsa04350__27	1.66287185899712e-18	UP	8.78039366768635	1.68893849894897e-17	TGF-beta signaling pathway: ACVR2A*
hsa04910__42	1.66287185899712e-18	DOWN	-8.78039366768635	1.68893849894897e-17	Insulin signaling pathway: PCK1
hsa03320__22	1.7326420304421e-18	DOWN	-8.77576875661567	1.69564290375037e-17	PPAR signaling pathway: ACADM
hsa04066__63	1.7326420304421e-18	UP	8.77576875661567	1.69564290375037e-17	HIF-1 signaling pathway: TIMP1*
hsa04066__57	1.7326420304421e-18	UP	8.77576875661567	1.69564290375037e-17	HIF-1 signaling pathway: TIMP1
hsa04210__73	1.7326420304421e-18	UP	8.77576875661567	1.69564290375037e-17	Apoptosis: TRAF1
hsa04917__75	1.7326420304421e-18	UP	8.77576875661567	1.69564290375037e-17	Prolactin signaling pathway: CCND1**
hsa05161__126	1.7326420304421e-18	UP	8.77576875661567	1.69564290375037e-17	Hepatitis B: MYC*
hsa05210__21	1.7326420304421e-18	UP	8.77576875661567	1.69564290375037e-17	Colorectal cancer: BIRC5
hsa04071__66	1.88096812766405e-18	UP	8.76651893447431	1.82182428447461e-17	Sphingolipid signaling pathway: C01245
hsa05200__197	1.88096812766405e-18	UP	8.76651893447431	1.82182428447461e-17	Pathways in cancer: CCND1**
hsa04010__15	1.95976486207295e-18	UP	8.76189402340363	1.85979705850256e-17	MAPK signaling pathway: NFKB1
hsa04151__24	1.95976486207295e-18	UP	8.76189402340363	1.85979705850256e-17	PI3K-Akt signaling pathway: MYC
hsa04210__4	1.95976486207295e-18	DOWN	-8.76189402340363	1.85979705850256e-17	Apoptosis: DFFA
hsa04668__36	1.95976486207295e-18	UP	8.76189402340363	1.85979705850256e-17	TNF signaling pathway: CREB3
hsa03320__38	2.04181937088657e-18	UP	8.75726911233295	1.92792894366627e-17	PPAR signaling pathway: SORBS1
hsa04115__23	2.12726451595056e-18	UP	8.75264420126227	1.98862190321946e-17	p53 signaling pathway: PTEN
hsa04742__34	2.12726451595056e-18	DOWN	-8.75264420126227	1.98862190321946e-17	Taste transduction: GRM1
hsa04066__58	2.21623850114989e-18	UP	8.74801929019159	2.04132948218659e-17	HIF-1 signaling pathway: EDN1
hsa04610__44	2.21623850114989e-18	UP	8.74801929019159	2.04132948218659e-17	Complement and coagulation cascades: C3
hsa04933__35	2.21623850114989e-18	UP	8.74801929019159	2.04132948218659e-17	AGE-RAGE signaling pathway in diabetic complications: CCND1
hsa04620__48	2.30888508404056e-18	UP	8.74339437912091	2.09584303039237e-17	Toll-like receptor signaling pathway: CD80
hsa05205__304	2.30888508404056e-18	DOWN	-8.74339437912091	2.09584303039237e-17	Proteoglycans in cancer: MAPK1*****
hsa05205__337	2.30888508404056e-18	DOWN	-8.74339437912091	2.09584303039237e-17	Proteoglycans in cancer: CTNNB1**
hsa03320__66	2.40535379573619e-18	UP	8.73876946805023	2.16251664219536e-17	PPAR signaling pathway: UCP1
hsa04623__25	2.40535379573619e-18	UP	8.73876946805023	2.16251664219536e-17	Cytosolic DNA-sensing pathway: NFKB1*
hsa03320__57	2.50580016936703e-18	DOWN	-8.73414455697955	2.24209453249555e-17	PPAR signaling pathway: APOC3
hsa05164__77	2.61038597743976e-18	DOWN	-8.72951964590887	2.31363926962704e-17	Influenza A: CASP9
hsa05220__15	2.61038597743976e-18	UP	8.72951964590887	2.31363926962704e-17	Chronic myeloid leukemia: MYC
hsa04152__62	2.71927947843957e-18	UP	8.72489473483819	2.37652378604091e-17	AMPK signaling pathway: EIF4EBP1
hsa04380__72	2.71927947843957e-18	UP	8.72489473483819	2.37652378604091e-17	Osteoclast differentiation: MAPK1
hsa04610__17	2.71927947843957e-18	DOWN	-8.72489473483819	2.37652378604091e-17	Complement and coagulation cascades: PLG
hsa04010__117	2.83265567302833e-18	UP	8.72026982376751	2.40839819439829e-17	MAPK signaling pathway: JUND
hsa04115__16	2.83265567302833e-18	UP	8.72026982376751	2.40839819439829e-17	p53 signaling pathway: PPM1D
hsa04530__22 33	2.83265567302833e-18	DOWN	-8.72026982376751	2.40839819439829e-17	Tight junction: MYL12B CGN
hsa05162__58	2.83265567302833e-18	UP	8.72026982376751	2.40839819439829e-17	Measles: STAT3
hsa05211__21	2.83265567302833e-18	UP	8.72026982376751	2.40839819439829e-17	Renal cell carcinoma: TGFB1*
hsa05321__94	2.83265567302833e-18	UP	8.72026982376751	2.40839819439829e-17	Inflammatory bowel disease (IBD): IL22
hsa05231__39	3.07359146381957e-18	UP	8.71102000162615	2.60147673897161e-17	Choline metabolism in cancer: EIF4EBP1
hsa03460__48	3.33473857459189e-18	UP	8.70177017948479	2.78487723629252e-17	Fanconi anemia pathway: RAD51
hsa05161__130	3.33473857459189e-18	UP	8.70177017948479	2.78487723629252e-17	Hepatitis B: FASLG*
hsa05166__83	3.33473857459189e-18	UP	8.70177017948479	2.78487723629252e-17	HTLV-I infection: NFKB2
hsa03320__55	3.4734084450714e-18	UP	8.69714526841411	2.86251511767068e-17	PPAR signaling pathway: SCD
hsa04115__1	3.4734084450714e-18	UP	8.69714526841411	2.86251511767068e-17	p53 signaling pathway: SIAH1
hsa04610__11	3.4734084450714e-18	UP	8.69714526841411	2.86251511767068e-17	Complement and coagulation cascades: F2R
hsa05152__120	3.61776825059384e-18	UP	8.69252035734342	2.96846573924272e-17	Tuberculosis: TGFB1
hsa05142__67	3.7680482474365e-18	UP	8.68789544627274	3.06500547919185e-17	Chagas disease (American trypanosomiasis): IFNGR1*
hsa05200__189	3.7680482474365e-18	UP	8.68789544627274	3.06500547919185e-17	Pathways in cancer: BIRC5
hsa04610__58	3.92448787622631e-18	UP	8.68327053520206	3.16485524439023e-17	Complement and coagulation cascades: F2RL2
hsa05205__352	3.92448787622631e-18	UP	8.68327053520206	3.16485524439023e-17	Proteoglycans in cancer: ITGA5*
hsa04917__44	4.08733612280819e-18	DOWN	-8.67864562413138	3.25428159947313e-17	Prolactin signaling pathway: PRLR**
hsa04919__25	4.08733612280819e-18	DOWN	-8.67864562413138	3.25428159947313e-17	Thyroid hormone signaling pathway: MTOR
hsa04919__28	4.08733612280819e-18	DOWN	-8.67864562413138	3.25428159947313e-17	Thyroid hormone signaling pathway: RCAN1
hsa05164__70	4.25685189307068e-18	UP	8.6740207130607	3.34670489835975e-17	Influenza A: RNASEL
hsa05168__83	4.25685189307068e-18	UP	8.6740207130607	3.34670489835975e-17	Herpes simplex infection: RNASEL
hsa05218__9	4.25685189307068e-18	UP	8.6740207130607	3.34670489835975e-17	Melanoma: CCND1
hsa05164__24	4.43330440226113e-18	UP	8.66939580199002	3.47090790493694e-17	Influenza A: IRF7
hsa04062__53	4.61697357933986e-18	UP	8.66477089091934	3.58483196511553e-17	Chemokine signaling pathway: NFKB1
hsa05200__75	4.61697357933986e-18	UP	8.66477089091934	3.58483196511553e-17	Pathways in cancer: MAPK8
hsa04152__82	4.80815048694583e-18	DOWN	-8.66014597984866	3.68755704692703e-17	AMPK signaling pathway: HMGCR
hsa04668__138	4.80815048694583e-18	UP	8.66014597984866	3.68755704692703e-17	TNF signaling pathway: NFKB1*
hsa05321__152	4.80815048694583e-18	UP	8.66014597984866	3.68755704692703e-17	Inflammatory bowel disease (IBD): FOXP3*
hsa04115__30	5.00713775756623e-18	UP	8.65552106877798	3.82455766116542e-17	p53 signaling pathway: SERPINE1
hsa04921__65	5.42981450242784e-18	UP	8.64627124663662	4.11396026212174e-17	Oxytocin signaling pathway: TRPM2
hsa05160__70	5.42981450242784e-18	UP	8.64627124663662	4.11396026212174e-17	Hepatitis C: CDKN1A
hsa04919__29	5.65417125572662e-18	DOWN	-8.64164633556594	4.24967511580413e-17	Thyroid hormone signaling pathway: HIF1A
hsa05211__42	5.65417125572662e-18	UP	8.64164633556594	4.24967511580413e-17	Renal cell carcinoma: SLC2A1*
hsa04742__8	5.88714354253758e-18	UP	8.63702142449526	4.40714849260084e-17	Taste transduction: PLCB2
hsa04010__62	6.13069014927361e-18	UP	8.63239651342458	4.57125666289092e-17	MAPK signaling pathway: MEF2C
hsa04066__5	6.92071837280648e-18	UP	8.61852178021254	5.11969678051314e-17	HIF-1 signaling pathway: VEGFA
hsa04540__10	6.92071837280648e-18	UP	8.61852178021254	5.11969678051314e-17	Gap junction: C00533
hsa04064__25	7.20576508385102e-18	UP	8.61389686914186	5.28891898146721e-17	NF-kappa B signaling pathway: NFKB2
hsa04390__13	7.20576508385102e-18	UP	8.61389686914186	5.28891898146721e-17	Hippo signaling pathway: BIRC5
hsa04612__17 28	7.81106811931487e-18	UP	8.6046470470005	5.7108937728376e-17	Antigen processing and presentation: CD4 HLA-DMA
hsa04662__27	8.4665028427583e-18	DOWN	-8.59539722485914	6.1423007110204e-17	B cell receptor signaling pathway: NFATC1
hsa05211__27	8.4665028427583e-18	UP	8.59539722485914	6.1423007110204e-17	Renal cell carcinoma: VEGFA*
hsa04370__15	8.81428554750407e-18	UP	8.59077231378846	6.37001636298467e-17	VEGF signaling pathway: PLA2G4B
hsa04066__61	1.03520799739379e-17	UP	8.57227266950574	7.39602976084764e-17	HIF-1 signaling pathway: HMOX1
hsa04370__28	1.03520799739379e-17	UP	8.57227266950574	7.39602976084764e-17	VEGF signaling pathway: SHC2
hsa05211__4	1.03520799739379e-17	UP	8.57227266950574	7.39602976084764e-17	Renal cell carcinoma: SLC2A1
hsa04510__47	1.07761794058006e-17	UP	8.56764775843506	7.64092117113179e-17	Focal adhesion: CCND1
hsa05221__35	1.07761794058006e-17	UP	8.56764775843506	7.64092117113179e-17	Acute myeloid leukemia: EIF4EBP1
hsa04151__96	1.16764731749356e-17	UP	8.5583979362937	8.24815529913681e-17	PI3K-Akt signaling pathway: BCL2
hsa04064__36	1.21540596761678e-17	UP	8.55377302522302	8.52144706399976e-17	NF-kappa B signaling pathway: PLCG1
hsa04668__128	1.21540596761678e-17	UP	8.55377302522302	8.52144706399976e-17	TNF signaling pathway: CHUK*
hsa05166__5	1.31677995259114e-17	UP	8.54452320308166	9.16381307747689e-17	HTLV-I infection: SLC2A1
hsa05211__2	1.31677995259114e-17	UP	8.54452320308166	9.16381307747689e-17	Renal cell carcinoma: TGFB1
hsa04370__36	1.3705515316947e-17	UP	8.53989829201098	9.43320999287302e-17	VEGF signaling pathway: NOS3
hsa05031__10	1.3705515316947e-17	UP	8.53989829201098	9.43320999287302e-17	Amphetamine addiction: CACNA1C
hsa05031__53	1.3705515316947e-17	UP	8.53989829201098	9.43320999287302e-17	Amphetamine addiction: CACNA1C*
hsa04610__23	1.42648878372263e-17	DOWN	-8.5352733809403	9.78238111173293e-17	Complement and coagulation cascades: BDKRB1
hsa04650__35	1.48467768740101e-17	UP	8.53064846986962	1.01443977259145e-16	Natural killer cell mediated cytotoxicity: BID
hsa04071__48	1.54507189690349e-17	DOWN	-8.52602355879894	1.04440469443967e-16	Sphingolipid signaling pathway: SMPD1
hsa04210__107	1.54520758410978e-17	DOWN	-8.52602355879894	1.04440469443967e-16	Apoptosis: MCL1
hsa05160__54	1.54520758410978e-17	UP	8.52602355879894	1.04440469443967e-16	Hepatitis C: IRF1
hsa04668__102	1.67366531714321e-17	UP	8.51677373665758	1.12717459889322e-16	TNF signaling pathway: AKT3
hsa04115__39	1.74178983944658e-17	UP	8.5121488255869	1.16886539582861e-16	p53 signaling pathway: BAX
hsa04012__57	1.81264901093835e-17	UP	8.50752391451622	1.21208807528582e-16	ErbB signaling pathway: ABL1
hsa04621__23	1.88635102920438e-17	UP	8.50289900344554	1.24804703657572e-16	NOD-like receptor signaling pathway: CASP1
hsa05152__112	1.88635102920438e-17	UP	8.50289900344554	1.24804703657572e-16	Tuberculosis: IFNGR1
hsa05214__52	1.88635102920438e-17	UP	8.50289900344554	1.24804703657572e-16	Glioma: E2F1*
hsa04015__27	1.96300830862837e-17	UP	8.49827409237486	1.28518906338422e-16	Rap1 signaling pathway: RALA
hsa04114__80	1.96300830862837e-17	UP	8.49827409237486	1.28518906338422e-16	Oocyte meiosis: CDC25C*
hsa04668__38	1.96300830862837e-17	UP	8.49827409237486	1.28518906338422e-16	TNF signaling pathway: CEBPB
hsa04930__3	2.04273764216342e-17	UP	8.49364918130418	1.33274445473093e-16	Type II diabetes mellitus: SLC2A4
hsa04210__3	2.12566036920797e-17	UP	8.4890242702335	1.37728132197992e-16	Apoptosis: BCL2L1
hsa04950__31	2.12566036920797e-17	DOWN	-8.4890242702335	1.37728132197992e-16	Maturity onset diabetes of the young: NKX6-1*
hsa04064__142	2.21190254981289e-17	UP	8.48439935916282	1.42334414078713e-16	NF-kappa B signaling pathway: NFKB2*
hsa05210__31	2.21190254981289e-17	UP	8.48439935916282	1.42334414078713e-16	Colorectal cancer: BCL2
hsa04068__41	2.49188106741782e-17	UP	8.47052462595077	1.59803567429286e-16	FoxO signaling pathway: CDKN2B
hsa04210__52	2.69767116210159e-17	DOWN	-8.46127480380941	1.72412384815948e-16	Apoptosis: PARP2
hsa04152__58	2.80676533839492e-17	UP	8.45664989273874	1.78172705096083e-16	AMPK signaling pathway: SCD
hsa05211__3	2.80676533839492e-17	UP	8.45664989273874	1.78172705096083e-16	Renal cell carcinoma: VEGFA
hsa05110__13	2.91995758947836e-17	DOWN	-8.45202498166806	1.82902463922353e-16	Vibrio cholerae infection: C00238
hsa03320__10	2.92020964218765e-17	UP	8.45202498166806	1.82902463922353e-16	PPAR signaling pathway: PLIN1
hsa04662__32 51	2.92020964218765e-17	DOWN	-8.45202498166806	1.82902463922353e-16	B cell receptor signaling pathway: BLNK GRB2
hsa05031__96	2.92020964218765e-17	DOWN	-8.45202498166806	1.82902463922353e-16	Amphetamine addiction: PDYN
hsa04620__76	3.03817501142458e-17	UP	8.44740007059738	1.89658832108531e-16	Toll-like receptor signaling pathway: CCL3L3
hsa04064__52	3.1608389991337e-17	UP	8.4427751595267	1.96013745193803e-16	NF-kappa B signaling pathway: TRAF1
hsa04390__78	3.1608389991337e-17	DOWN	-8.4427751595267	1.96013745193803e-16	Hippo signaling pathway: SOX2
hsa04010__131	3.42100763854411e-17	UP	8.43352533738533	2.10756503371292e-16	MAPK signaling pathway: MYC
hsa04933__43	3.42100763854411e-17	UP	8.43352533738533	2.10756503371292e-16	AGE-RAGE signaling pathway in diabetic complications: CASP3
hsa04010__67	3.55890278666026e-17	UP	8.42890042631465	2.17823398571161e-16	MAPK signaling pathway: ELK1
hsa04922__36	3.55890278666026e-17	UP	8.42890042631465	2.17823398571161e-16	Glucagon signaling pathway: GYS1
hsa03320__20	3.70227809852775e-17	DOWN	-8.42427551524397	2.24405824101085e-16	PPAR signaling pathway: SCP2
hsa04623__17	3.70227809852775e-17	UP	8.42427551524397	2.24405824101085e-16	Cytosolic DNA-sensing pathway: NFKB1
hsa04650__36	3.70227809852775e-17	UP	8.42427551524397	2.24405824101085e-16	Natural killer cell mediated cytotoxicity: CASP3
hsa05215__14	3.85134817561438e-17	UP	8.41965060417329	2.32690778841782e-16	Prostate cancer: CCND1
hsa04670__2	4.00633589475026e-17	UP	8.41502569310261	2.41279011097299e-16	Leukocyte transendothelial migration: MMP2
hsa04933__28	4.33499903910258e-17	UP	8.40577587096125	2.5940965587496e-16	AGE-RAGE signaling pathway in diabetic complications: VCAM1
hsa05216__15	4.33499903910258e-17	UP	8.40577587096125	2.5940965587496e-16	Thyroid cancer: CCND1
hsa05145__33	4.50916447992625e-17	UP	8.40115095989057	2.67278235261244e-16	Toxoplasmosis: STAT3
hsa05169__103	4.50916447992625e-17	UP	8.40115095989057	2.67278235261244e-16	Epstein-Barr virus infection: NFKB1*
hsa05169__125	4.50916447992625e-17	UP	8.40115095989057	2.67278235261244e-16	Epstein-Barr virus infection: STAT3
hsa03320__31	4.6902282823545e-17	UP	8.39652604881989	2.75404341954503e-16	PPAR signaling pathway: CD36
hsa04064__51	4.6902282823545e-17	UP	8.39652604881989	2.75404341954503e-16	NF-kappa B signaling pathway: TNFAIP3
hsa05169__104	4.6902282823545e-17	UP	8.39652604881989	2.75404341954503e-16	Epstein-Barr virus infection: IRF3
hsa05166__64	4.87845965109246e-17	UP	8.39190113774921	2.85564663065505e-16	HTLV-I infection: CCNB2
hsa04062__38	5.07413813485424e-17	UP	8.38727622667853	2.93363247858188e-16	Chemokine signaling pathway: NCF1
hsa04064__96	5.07413813485424e-17	UP	8.38727622667853	2.93363247858188e-16	NF-kappa B signaling pathway: BCL2A1
hsa04370__39	5.07413813485424e-17	UP	8.38727622667853	2.93363247858188e-16	VEGF signaling pathway: RAC1
hsa05166__32	5.07413813485424e-17	UP	8.38727622667853	2.93363247858188e-16	HTLV-I infection: STAT5A
hsa04931__140	5.27755401743137e-17	UP	8.38265131560785	3.04187852722501e-16	Insulin resistance: G00369
hsa04390__75	5.48900872329631e-17	DOWN	-8.37802640453717	3.12540830032538e-16	Hippo signaling pathway: NKD1
hsa04550__66	5.48900872329631e-17	UP	8.37802640453717	3.12540830032538e-16	Signaling pathways regulating pluripotency of stem cells: MYC
hsa04913__21	5.48900872329631e-17	DOWN	-8.37802640453717	3.12540830032538e-16	Ovarian steroidogenesis: CYP17A1
hsa04913__22	5.48900872329631e-17	DOWN	-8.37802640453717	3.12540830032538e-16	Ovarian steroidogenesis: CYP17A1*
hsa04071__69	6.94494510122431e-17	UP	8.35027693811309	3.94246279311193e-16	Sphingolipid signaling pathway: RAC1
hsa03320__64	7.22213967047743e-17	UP	8.34565202704241	4.08747001229731e-16	PPAR signaling pathway: APOA5
hsa04950__7	7.5102394308836e-17	DOWN	-8.34102711597173	4.237759726916e-16	Maturity onset diabetes of the young: FOXA3
hsa04670__28 41 49	8.1208611260482e-17	UP	8.33177729383037	4.55495464353569e-16	Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1
hsa05169__118	8.1208611260482e-17	UP	8.33177729383037	4.55495464353569e-16	Epstein-Barr virus infection: MDM2
hsa05213__31	8.7803882699232e-17	UP	8.32252747168901	4.91022308309098e-16	Endometrial cancer: MYC
hsa04540__18 19	9.49267681551869e-17	UP	8.31327764954765	5.27714193383421e-16	Gap junction: GJA1 GJA1***
hsa05169__117	9.49267681551869e-17	UP	8.31327764954765	5.27714193383421e-16	Epstein-Barr virus infection: CDKN1A
hsa04151__97	9.86989276752961e-17	UP	8.30865273847697	5.47065737763662e-16	PI3K-Akt signaling pathway: MCL1
hsa04310__57	1.02618817984734e-16	UP	8.30402782740629	5.67119879392105e-16	Wnt signaling pathway: SIAH1
hsa05205__431	1.06692137602942e-16	UP	8.29940291633561	5.87901837407413e-16	Proteoglycans in cancer: CDKN1A*
hsa05200__210	1.15322948697521e-16	UP	8.29015309419425	6.33601814627607e-16	Pathways in cancer: MMP1
hsa04370__25	1.19892951600405e-16	UP	8.28552818312357	6.5298219147003e-16	VEGF signaling pathway: PXN
hsa04666__27	1.19892951600405e-16	UP	8.28552818312357	6.5298219147003e-16	Fc gamma R-mediated phagocytosis: ARPC5
hsa04670__39	1.19892951600405e-16	UP	8.28552818312357	6.5298219147003e-16	Leukocyte transendothelial migration: MAPK14
hsa04064__114	1.24641423723207e-16	UP	8.28090327205289	6.71063711105745e-16	NF-kappa B signaling pathway: BCL2A1*
hsa04066__64	1.24641423723207e-16	UP	8.28090327205289	6.71063711105745e-16	HIF-1 signaling pathway: LTBR
hsa04210__119	1.24641423723207e-16	UP	8.28090327205289	6.71063711105745e-16	Apoptosis: BCL2*
hsa04510__20 69	1.24641423723207e-16	UP	8.28090327205289	6.71063711105745e-16	Focal adhesion: VASP ACTB
hsa04510__20 4 5	1.29575229169111e-16	UP	8.27627836098221	6.93652010281366e-16	Focal adhesion: VASP ITGB1 ITGA11
hsa04933__24	1.29575229169111e-16	UP	8.27627836098221	6.93652010281366e-16	AGE-RAGE signaling pathway in diabetic complications: THBD
hsa04920__10	1.34701491864801e-16	DOWN	-8.27165344991153	7.17008790974393e-16	Adipocytokine signaling pathway: PCK1
hsa05216__11	1.34701491864801e-16	UP	8.27165344991153	7.17008790974393e-16	Thyroid cancer: MYC
hsa04911__31	1.4002760523245e-16	UP	8.26702853884085	7.43253870711223e-16	Insulin secretion: CAMK2A
hsa04012__35	1.45561242215512e-16	UP	8.26240362777017	7.6613326084859e-16	ErbB signaling pathway: CBLC
hsa04115__15	1.45561242215512e-16	UP	8.26240362777017	7.6613326084859e-16	p53 signaling pathway: TSC2
hsa04210__57	1.45561242215512e-16	UP	8.26240362777017	7.6613326084859e-16	Apoptosis: BAK1
hsa04064__113	1.57283239141234e-16	UP	8.25315380562881	8.25517336163067e-16	NF-kappa B signaling pathway: CFLAR
hsa04931__87	1.63488438019256e-16	DOWN	-8.24852889455813	8.53318819550506e-16	Insulin resistance: C00031*
hsa05223__37	1.63488438019256e-16	UP	8.24852889455813	8.53318819550506e-16	Non-small cell lung cancer: CCND1*
hsa04151__51	1.69934861121016e-16	UP	8.24390398348745	8.79635272855067e-16	PI3K-Akt signaling pathway: NOS3
hsa04210__105	1.69934861121016e-16	DOWN	-8.24390398348745	8.79635272855067e-16	Apoptosis: ACTB
hsa04650__25	1.69934861121016e-16	UP	8.24390398348745	8.79635272855067e-16	Natural killer cell mediated cytotoxicity: SH2D1B
hsa04724__66	1.83588664778116e-16	DOWN	-8.23465416134609	9.47700827247471e-16	Glutamatergic synapse: PLA2G4B
hsa04380__48	2.22635269034806e-16	UP	8.21152960599268	1.14611416579836e-15	Osteoclast differentiation: NFATC1
hsa04024__92	2.49880791882143e-16	UP	8.19765487278064	1.28285794520915e-15	cAMP signaling pathway: GRIN3A
hsa04066__54	2.80407304564996e-16	UP	8.1837801395686	1.4317536012979e-15	HIF-1 signaling pathway: SERPINE1
hsa05034__62	2.80407304564996e-16	UP	8.1837801395686	1.4317536012979e-15	Alcoholism: NPY
hsa03320__42	2.9137781485386e-16	DOWN	-8.17915522849792	1.47972679489298e-15	PPAR signaling pathway: ACOX1
hsa04066__55	2.9137781485386e-16	UP	8.17915522849792	1.47972679489298e-15	HIF-1 signaling pathway: ANGPT1
hsa04066__46	3.02771142538421e-16	UP	8.17453031742724	1.52931983018735e-15	HIF-1 signaling pathway: ENO1
hsa04933__65	3.02771142538421e-16	UP	8.17453031742724	1.52931983018735e-15	AGE-RAGE signaling pathway in diabetic complications: COL1A1
hsa05110__12	3.26891020229087e-16	DOWN	-8.16528049528588	1.6423214625948e-15	Vibrio cholerae infection: C00080
hsa05120__35	3.26891020229087e-16	DOWN	-8.16528049528588	1.6423214625948e-15	Epithelial cell signaling in Helicobacter pylori infection: C00080
hsa04024__60	3.39651474320806e-16	UP	8.1606555842152	1.68837333399152e-15	cAMP signaling pathway: PDE3A
hsa04151__34	3.39651474320806e-16	UP	8.1606555842152	1.68837333399152e-15	PI3K-Akt signaling pathway: GYS1
hsa05161__214	3.39651474320806e-16	UP	8.1606555842152	1.68837333399152e-15	Hepatitis B: CDKN1B
hsa05162__28 34	3.39651474320806e-16	UP	8.1606555842152	1.68837333399152e-15	Measles: IRF9 STAT1
hsa04151__110	3.52902598712844e-16	UP	8.15603067314452	1.74501048153009e-15	PI3K-Akt signaling pathway: BCL2**
hsa05213__29	3.52902598712844e-16	UP	8.15603067314452	1.74501048153009e-15	Endometrial cancer: CCND1
hsa05152__77	3.80951842462389e-16	UP	8.14678085100316	1.8787624986531e-15	Tuberculosis: IL12A
hsa05222__34	3.95789208075109e-16	UP	8.14215593993248	1.94682702087207e-15	Small cell lung cancer: CCND1
hsa04152__30	4.11195788026936e-16	DOWN	-8.1375310288618	2.01207522318389e-15	AMPK signaling pathway: ACACA
hsa05164__19	4.11195788026936e-16	UP	8.1375310288618	2.01207522318389e-15	Influenza A: NFKB1
hsa04210__83	4.2719307723106e-16	UP	8.13290611779112	2.06880358793083e-15	Apoptosis: TP53*
hsa04660__30	4.2719307723106e-16	UP	8.13290611779112	2.06880358793083e-15	T cell receptor signaling pathway: CD40LG
hsa04921__33	4.2719307723106e-16	UP	8.13290611779112	2.06880358793083e-15	Oxytocin signaling pathway: C00942
hsa05200__218	4.2719307723106e-16	UP	8.13290611779112	2.06880358793083e-15	Pathways in cancer: CSF3R*
hsa04210__24	4.61049784142525e-16	UP	8.12365629564976	2.21563310589208e-15	Apoptosis: CASP10
hsa04370__14	4.61049784142525e-16	UP	8.12365629564976	2.21563310589208e-15	VEGF signaling pathway: PTGS2
hsa04917__57	4.61049784142525e-16	DOWN	-8.12365629564976	2.21563310589208e-15	Prolactin signaling pathway: ESR1
hsa04068__48	5.36889780303823e-16	UP	8.10515665136704	2.57350994181348e-15	FoxO signaling pathway: FASLG
hsa05212__29	5.79293741898374e-16	UP	8.09590682922568	2.76970214001793e-15	Pancreatic cancer: VEGFA
hsa04064__3	6.24994074071026e-16	UP	8.08665700708432	2.97307307640369e-15	NF-kappa B signaling pathway: BCL2
hsa05200__65	6.24994074071026e-16	UP	8.08665700708432	2.97307307640369e-15	Pathways in cancer: STK4
hsa04064__132	6.49158416853987e-16	UP	8.08203209601364	3.07246515181018e-15	NF-kappa B signaling pathway: VCAM1
hsa04917__56	6.49158416853987e-16	DOWN	-8.08203209601364	3.07246515181018e-15	Prolactin signaling pathway: LHCGR
hsa04062__43	7.00281739560042e-16	UP	8.07278227387228	3.28137004646713e-15	Chemokine signaling pathway: STAT1
hsa04210__71	7.00281739560042e-16	UP	8.07278227387228	3.28137004646713e-15	Apoptosis: GADD45G
hsa04666__30 44	7.00281739560042e-16	UP	8.07278227387228	3.28137004646713e-15	Fc gamma R-mediated phagocytosis: C04637 GSN
hsa05130__55	7.00281739560042e-16	UP	8.07278227387228	3.28137004646713e-15	Pathogenic Escherichia coli infection: ACTB
hsa04115__55	7.55367468754895e-16	UP	8.06353245173092	3.52192425258176e-15	p53 signaling pathway: SHISA5
hsa04742__27	7.55367468754895e-16	DOWN	-8.06353245173092	3.52192425258176e-15	Taste transduction: CALHM1
hsa04916__10	7.84489757034046e-16	UP	8.05890754066024	3.64865409274003e-15	Melanogenesis: CAMK2A
hsa04115__36	8.14717639854919e-16	UP	8.05428262958956	3.77988751922813e-15	p53 signaling pathway: EI24
hsa04370__16	8.46092418750152e-16	UP	8.04965771851888	3.9061613140824e-15	VEGF signaling pathway: HSPB1
hsa04668__141	8.46092418750152e-16	UP	8.04965771851888	3.9061613140824e-15	TNF signaling pathway: JUN*
hsa05215__13	8.78656912307166e-16	UP	8.0450328074482	4.04655965251266e-15	Prostate cancer: BCL2
hsa04931__135	9.12455510911276e-16	UP	8.04040789637752	4.19194108802516e-15	Insulin resistance: SREBF1**
hsa05210__22	1.02172462225801e-15	UP	8.02653316316548	4.68248918347024e-15	Colorectal cancer: MYC
hsa04668__120	1.06093700734296e-15	DOWN	-8.0219082520948	4.83859377863451e-15	TNF signaling pathway: DNM1L
hsa05010__47	1.06093700734296e-15	DOWN	-8.0219082520948	4.83859377863451e-15	Alzheimer's disease: C00533
hsa03320__46	1.14386193019906e-15	DOWN	-8.01265842995344	5.15423637132862e-15	PPAR signaling pathway: APOA2
hsa03320__26	1.14386193019906e-15	DOWN	-8.01265842995344	5.15423637132862e-15	PPAR signaling pathway: CPT2
hsa04064__131	1.14386193019906e-15	UP	8.01265842995344	5.15423637132862e-15	NF-kappa B signaling pathway: CCL4L1
hsa04740__10	1.14386193019906e-15	UP	8.01265842995344	5.15423637132862e-15	Olfactory transduction: ANO2
hsa05161__213	1.14386193019906e-15	UP	8.01265842995344	5.15423637132862e-15	Hepatitis B: E2F1
hsa05220__6	1.2331644229524e-15	UP	8.00340860781208	5.54333959504201e-15	Chronic myeloid leukemia: TP53
hsa04540__22	1.28025746820568e-15	DOWN	-7.9987836967414	5.7412978108794e-15	Gap junction: C00547
hsa03320__33	1.4328669710831e-15	UP	7.98490896352935	6.41037390158366e-15	PPAR signaling pathway: CYP7A1
hsa04064__50	1.48757613757122e-15	UP	7.98028405245867	6.62359138032303e-15	NF-kappa B signaling pathway: NFKBIA*
hsa04115__56	1.48757613757122e-15	UP	7.98028405245867	6.62359138032303e-15	p53 signaling pathway: SESN3
hsa04919__27	1.54434163015982e-15	DOWN	-7.97565914138799	6.84391019592051e-15	Thyroid hormone signaling pathway: GATA4
hsa05205__22	1.54434163015982e-15	UP	7.97565914138799	6.84391019592051e-15	Proteoglycans in cancer: PPP1R12A
hsa05212__8	1.60323947912582e-15	UP	7.97103423031731	7.08820466182922e-15	Pancreatic cancer: NFKB1
hsa04360__82	1.66434847783729e-15	DOWN	-7.96640931924663	7.34110514050766e-15	Axon guidance: ILK
hsa04210__74	1.72775028136531e-15	UP	7.96178440817595	7.60291048872464e-15	Apoptosis: BAX*
hsa04961__12	1.86177384762994e-15	DOWN	-7.95253458603459	8.17353518620715e-15	Endocrine and other factor-regulated calcium reabsorption: SLC8A1
hsa04151__101	1.93257416558405e-15	UP	7.94790967496391	8.46458474856044e-15	PI3K-Akt signaling pathway: PKN3
hsa04151__99	2.00602462126849e-15	UP	7.94328476389323	8.68506973125228e-15	PI3K-Akt signaling pathway: MYB
hsa04380__69	2.00602462126849e-15	UP	7.94328476389323	8.68506973125228e-15	Osteoclast differentiation: NFKB2
hsa04723__73	2.00602462126849e-15	UP	7.94328476389323	8.68506973125228e-15	Retrograde endocannabinoid signaling: MAPK14*
hsa04723__68	2.00602462126849e-15	UP	7.94328476389323	8.68506973125228e-15	Retrograde endocannabinoid signaling: MAPK14
hsa05211__49	2.00602462126849e-15	UP	7.94328476389323	8.68506973125228e-15	Renal cell carcinoma: TGFA*
hsa04660__14	2.08222278252334e-15	UP	7.93865985282255	8.97361607422329e-15	T cell receptor signaling pathway: NFKB1
hsa05211__22	2.08222278252334e-15	UP	7.93865985282255	8.97361607422329e-15	Renal cell carcinoma: TGFA
hsa04151__36	2.16126974735776e-15	DOWN	-7.93403494175187	9.25062837194813e-15	PI3K-Akt signaling pathway: PCK1
hsa04622__5 33	2.16126974735776e-15	UP	7.93403494175187	9.25062837194813e-15	RIG-I-like receptor signaling pathway: MAVS TMEM173
hsa04730__20	2.16126974735776e-15	DOWN	-7.93403494175187	9.25062837194813e-15	Long-term depression: C00025
hsa04066__29	2.4165700603629e-15	UP	7.92016020853983	1.03198525986861e-14	HIF-1 signaling pathway: LDHA
hsa04012__65	2.50809830523877e-15	UP	7.91553529746915	1.05903746416711e-14	ErbB signaling pathway: MYC
hsa04064__4	2.50809830523877e-15	UP	7.91553529746915	1.05903746416711e-14	NF-kappa B signaling pathway: BIRC2
hsa04910__9	2.50809830523877e-15	UP	7.91553529746915	1.05903746416711e-14	Insulin signaling pathway: ELK1
hsa05169__60	2.50809830523877e-15	UP	7.91553529746915	1.05903746416711e-14	Epstein-Barr virus infection: NFKB1
hsa05200__200	2.50809830523877e-15	UP	7.91553529746915	1.05903746416711e-14	Pathways in cancer: FIGF
hsa03320__58	2.60303834182724e-15	DOWN	-7.91091038639847	1.09420783988666e-14	PPAR signaling pathway: CYP8B1
hsa04270__28	2.60303834182724e-15	UP	7.91091038639847	1.09420783988666e-14	Vascular smooth muscle contraction: KCNMB2
hsa04950__15	2.70151524109147e-15	DOWN	-7.90628547532779	1.13306855759171e-14	Maturity onset diabetes of the young: IAPP
hsa05200__207	2.80365857922228e-15	UP	7.90166056425711	1.17329052791953e-14	Pathways in cancer: CDK4
hsa05200__190	2.90960259695474e-15	UP	7.89703565318643	1.21492072881732e-14	Pathways in cancer: MYC*
hsa04390__76	3.01948636440995e-15	UP	7.89241074211575	1.25245361561287e-14	Hippo signaling pathway: MYC
hsa04530__20 62	3.01948636440995e-15	DOWN	-7.89241074211575	1.25245361561287e-14	Tight junction: ACTB SHROOM1
hsa05200__205	3.01948636440995e-15	UP	7.89241074211575	1.25245361561287e-14	Pathways in cancer: SLC2A1
hsa04970__21	3.1334539516495e-15	UP	7.88778583104507	1.29686343064965e-14	Salivary secretion: ITPR1
hsa05161__125	3.37424293030526e-15	UP	7.87853600890371	1.39345109143815e-14	Hepatitis B: CDKN1A
hsa04666__29	3.50137908044065e-15	UP	7.87391109783303	1.43648281487947e-14	Fc gamma R-mediated phagocytosis: WAS
hsa04742__31	3.50137908044065e-15	DOWN	-7.87391109783303	1.43648281487947e-14	Taste transduction: C00076*
hsa04919__84	3.50137908044065e-15	UP	7.87391109783303	1.43648281487947e-14	Thyroid hormone signaling pathway: TP53*
hsa04151__33	3.63322895209132e-15	UP	7.86928618676235	1.48732836622649e-14	PI3K-Akt signaling pathway: TP53
hsa04910__43	3.76996438722751e-15	DOWN	-7.86466127569167	1.53328205272738e-14	Insulin signaling pathway: G6PC
hsa05222__19	3.76996438722751e-15	DOWN	-7.86466127569167	1.53328205272738e-14	Small cell lung cancer: CASP9
hsa05231__59	3.76996438722751e-15	DOWN	-7.86466127569167	1.53328205272738e-14	Choline metabolism in cancer: PLA2G4B
hsa04066__52	3.91176338237764e-15	UP	7.86003636462099	1.58409555937233e-14	HIF-1 signaling pathway: FLT1
hsa04152__89	3.91176338237764e-15	DOWN	-7.86003636462099	1.58409555937233e-14	AMPK signaling pathway: CFTR
hsa04390__52	4.05881030497773e-15	UP	7.85541145355031	1.64010850818347e-14	Hippo signaling pathway: ITGB2
hsa04270__17	4.36941860735401e-15	UP	7.84616163140895	1.7618320951112e-14	Vascular smooth muscle contraction: ITPR1
hsa05152__68	4.53338262959589e-15	UP	7.84153672033827	1.8240312550344e-14	Tuberculosis: CD74
hsa04114__59	5.25201253383851e-15	UP	7.82303707605555	2.10866058783816e-14	Oocyte meiosis: REC8*
hsa04115__50	5.44852215285743e-15	UP	7.81841216498487	2.18289405654992e-14	p53 signaling pathway: RCHY1
hsa04668__116	5.65226529299219e-15	UP	7.81378725391419	2.25490583556949e-14	TNF signaling pathway: PGAM5
hsa05160__15 16	5.65226529299219e-15	UP	7.81378725391419	2.25490583556949e-14	Hepatitis C: TRAF6 RIPK1
hsa04151__98	5.86350370184207e-15	UP	7.80916234284351	2.32928614286707e-14	PI3K-Akt signaling pathway: BCL2L1*
hsa04611__34	5.86350370184207e-15	UP	7.80916234284351	2.32928614286707e-14	Platelet activation: C02198*
hsa05168__10	6.30956015343377e-15	UP	7.79991252070215	2.50119483719453e-14	Herpes simplex infection: FOS
hsa05164__31 32 33	6.54446789337695e-15	UP	7.79528760963147	2.58360507037488e-14	Influenza A: NLRP3 PYCARD CASP1
hsa05161__29	6.54494951303057e-15	UP	7.79528760963147	2.58360507037488e-14	Hepatitis B: NFKB1
hsa04210__51	7.04195560419894e-15	DOWN	-7.78603778749011	2.76238717751353e-14	Apoptosis: LMNA
hsa04915__21	7.04195560419894e-15	UP	7.78603778749011	2.76238717751353e-14	Estrogen signaling pathway: CREB3
hsa05205__319	7.04195560419894e-15	UP	7.78603778749011	2.76238717751353e-14	Proteoglycans in cancer: KDR
hsa05142__44	7.3042066097529e-15	UP	7.78141287641943	2.85929254577619e-14	Chagas disease (American trypanosomiasis): PLCB1
hsa04933__62	7.57606455374428e-15	UP	7.77678796534875	2.95954787868721e-14	AGE-RAGE signaling pathway in diabetic complications: AGER**
hsa04920__9	7.85787533545795e-15	DOWN	-7.77216305427807	3.05060904035651e-14	Adipocytokine signaling pathway: G6PC
hsa05132__68	7.85787533545795e-15	UP	7.77216305427807	3.05060904035651e-14	Salmonella infection: NOS2
hsa05200__191	7.85787533545795e-15	UP	7.77216305427807	3.05060904035651e-14	Pathways in cancer: CCND1*
hsa04920__43	8.14999708413516e-15	UP	7.76753814320739	3.15749371568865e-14	Adipocytokine signaling pathway: C00162
hsa04620__21	8.76666970879026e-15	UP	7.75828832106603	3.38245839482893e-14	Toll-like receptor signaling pathway: IFNA1
hsa04933__56	8.76666970879026e-15	UP	7.75828832106603	3.38245839482893e-14	AGE-RAGE signaling pathway in diabetic complications: NFATC1
hsa05200__202	9.42920854496481e-15	UP	7.74903849892467	3.6306317327846e-14	Pathways in cancer: FIGF*
hsa04210__106	1.01409640808696e-14	DOWN	-7.7397886767833	3.88874928733756e-14	Apoptosis: TUBA1B
hsa04728__32	1.01409640808696e-14	UP	7.7397886767833	3.88874928733756e-14	Dopaminergic synapse: CREB3
hsa04066__88	1.05164103530252e-14	UP	7.73516376571262	4.01632826287283e-14	HIF-1 signaling pathway: BCL2
hsa04971__39	1.05164103530252e-14	UP	7.73516376571262	4.01632826287283e-14	Gastric acid secretion: EZR
hsa04014__37	1.13088030294143e-14	UP	7.72591394357126	4.27550118556728e-14	Ras signaling pathway: FASLG
hsa04380__51	1.13088030294143e-14	UP	7.72591394357126	4.27550118556728e-14	Osteoclast differentiation: FOS*
hsa04922__50	1.13088030294143e-14	DOWN	-7.72591394357126	4.27550118556728e-14	Glucagon signaling pathway: PCK1
hsa05210__23	1.13088030294143e-14	UP	7.72591394357126	4.27550118556728e-14	Colorectal cancer: CCND1
hsa05321__46	1.13088030294143e-14	UP	7.72591394357126	4.27550118556728e-14	Inflammatory bowel disease (IBD): IFNG*
hsa04115__18	1.17267448617945e-14	UP	7.72128903250058	4.38935330583901e-14	p53 signaling pathway: CCNG1
hsa04152__87	1.17267448617945e-14	UP	7.72128903250058	4.38935330583901e-14	AMPK signaling pathway: CD36
hsa04670__45	1.17267448617945e-14	UP	7.72128903250058	4.38935330583901e-14	Leukocyte transendothelial migration: PXN
hsa05145__13	1.17267448617945e-14	UP	7.72128903250058	4.38935330583901e-14	Toxoplasmosis: GNAI1
hsa05150__69	1.17267448617945e-14	UP	7.72128903250058	4.38935330583901e-14	Staphylococcus aureus infection: FPR2
hsa04722__53	1.21598765373871e-14	UP	7.7166641214299	4.52443723044561e-14	Neurotrophin signaling pathway: JUN
hsa05200__226	1.21598765373871e-14	UP	7.7166641214299	4.52443723044561e-14	Pathways in cancer: CDKN1A*
hsa05215__24	1.21598765373871e-14	UP	7.7166641214299	4.52443723044561e-14	Prostate cancer: CDKN1A
hsa05210__53	1.26087405206625e-14	UP	7.71203921035922	4.68217854512347e-14	Colorectal cancer: CCND1*
hsa04510__23 4 5	1.35559310134464e-14	UP	7.70278938821786	5.02398311129503e-14	Focal adhesion: TLN1 ITGB1 ITGA11
hsa04213__54	1.4055440180898e-14	UP	7.69816447714718	5.18863891943169e-14	Longevity regulating pathway - multiple species: SOD2*
hsa04261__36	1.4055440180898e-14	UP	7.69816447714718	5.18863891943169e-14	Adrenergic signaling in cardiomyocytes: MAPK1
hsa04620__86	1.62410233671922e-14	UP	7.67966483286446	5.9719927410869e-14	Toll-like receptor signaling pathway: IL12A
hsa04922__17	1.62410233671922e-14	UP	7.67966483286446	5.9719927410869e-14	Glucagon signaling pathway: PKM
hsa04064__116	1.74559297210749e-14	UP	7.6704150107231	6.39370213370366e-14	NF-kappa B signaling pathway: GADD45B
hsa04668__153	1.74559297210749e-14	UP	7.6704150107231	6.39370213370366e-14	TNF signaling pathway: MAPK14*
hsa04932__31 133	1.87588024686833e-14	DOWN	-7.66116518858174	6.83145283263249e-14	Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA
hsa04723__42	1.87601365707204e-14	UP	7.66116518858174	6.83145283263249e-14	Retrograde endocannabinoid signaling: KCNJ3
hsa04723__50	1.87601365707204e-14	UP	7.66116518858174	6.83145283263249e-14	Retrograde endocannabinoid signaling: KCNJ3*
hsa04152__78	1.94477240263253e-14	UP	7.65654027751106	7.02736027797409e-14	AMPK signaling pathway: CCNA2
hsa04930__15	1.94477240263253e-14	DOWN	-7.65654027751106	7.02736027797409e-14	Type II diabetes mellitus: C00031*
hsa05014__31 34	1.94477240263253e-14	UP	7.65654027751106	7.02736027797409e-14	Amyotrophic lateral sclerosis (ALS): NEFL PRPH
hsa05205__369	1.94477240263253e-14	DOWN	-7.65654027751106	7.02736027797409e-14	Proteoglycans in cancer: HOXD10
hsa04660__56	2.0898105742419e-14	UP	7.6472904553697	7.53695598656533e-14	T cell receptor signaling pathway: CD3E
hsa04380__16	2.24547633397836e-14	UP	7.63804063322834	8.08285446656197e-14	Osteoclast differentiation: NFKB1
hsa04015__17	2.32753138192289e-14	UP	7.63341572215766	8.34624325693343e-14	Rap1 signaling pathway: ACTB
hsa05200__194	2.32753138192289e-14	UP	7.63341572215766	8.34624325693343e-14	Pathways in cancer: BCL2
hsa04370__37	2.41253411837277e-14	DOWN	-7.62879081108698	8.63457449223319e-14	VEGF signaling pathway: CASP9
hsa04913__64	2.5005885505572e-14	DOWN	-7.6241659000163	8.93271081083075e-14	Ovarian steroidogenesis: PLA2G4B
hsa04211__50	2.59180228679211e-14	UP	7.61954098894562	9.20604252718787e-14	Longevity regulating pathway - mammal: PPARGC1A*
hsa05161__100	2.59180228679211e-14	UP	7.61954098894562	9.20604252718787e-14	Hepatitis B: MMP9*
hsa05164__47	2.59180228679211e-14	UP	7.61954098894562	9.20604252718787e-14	Influenza A: CIITA
hsa04913__45	2.68628665869437e-14	DOWN	-7.61491607787494	9.50571117078479e-14	Ovarian steroidogenesis: ACOT2
hsa05162__93	2.68628665869437e-14	UP	7.61491607787494	9.50571117078479e-14	Measles: TP53
hsa04920__2	2.99053543534703e-14	UP	7.6010413446629	1.05624362462727e-13	Adipocytokine signaling pathway: C00638
hsa05321__138	3.21194155863304e-14	UP	7.59179152252154	1.13231485716163e-13	Inflammatory bowel disease (IBD): IFNG**
hsa04072__36	3.57459699491524e-14	DOWN	-7.5779167893095	1.2507761179601e-13	Phospholipase D signaling pathway: MTOR
hsa04390__95	3.57459699491524e-14	DOWN	-7.5779167893095	1.2507761179601e-13	Hippo signaling pathway: AFP
hsa05134__9	3.57459699491524e-14	UP	7.5779167893095	1.2507761179601e-13	Legionellosis: CASP7
hsa05219__10	3.57459699491524e-14	DOWN	-7.5779167893095	1.2507761179601e-13	Bladder cancer: EGFR
hsa04064__133	3.97744566191918e-14	UP	7.56404205609746	1.38914877300114e-13	NF-kappa B signaling pathway: CXCL2
hsa05152__98	4.2704796637591e-14	UP	7.5547922339561	1.48872565643847e-13	Tuberculosis: IL23A
hsa04115__54	4.42485605258328e-14	UP	7.55016732288542	1.53684002269944e-13	p53 signaling pathway: PERP
hsa05205__415	4.42485605258328e-14	UP	7.55016732288542	1.53684002269944e-13	Proteoglycans in cancer: MAPK1******
hsa04390__59	4.75025255949852e-14	UP	7.54091750074406	1.64681264931692e-13	Hippo signaling pathway: SERPINE1
hsa05164__20	4.92166178351073e-14	UP	7.53629258967338	1.70309438143953e-13	Influenza A: ATF2
hsa04810__26 80	5.09914885089319e-14	UP	7.5316676786027	1.76126850934344e-13	Regulation of actin cytoskeleton: PFN3 ACTB
hsa05152__129	5.28292533937396e-14	DOWN	-7.52704276753202	1.82139756196031e-13	Tuberculosis: IFNB1
hsa04668__47	5.47321005031397e-14	UP	7.52241785646134	1.88354609606959e-13	TNF signaling pathway: CASP7
hsa04012__43	5.67022925031472e-14	UP	7.51779294539066	1.94068502028076e-13	ErbB signaling pathway: PTK2
hsa04261__62	5.67022925031472e-14	UP	7.51779294539066	1.94068502028076e-13	Adrenergic signaling in cardiomyocytes: BCL2
hsa04724__5 71	5.67022925031472e-14	UP	7.51779294539066	1.94068502028076e-13	Glutamatergic synapse: GRIN3A DLG4
hsa04064__2	5.87421692073177e-14	UP	7.51316803431998	2.00684610801e-13	NF-kappa B signaling pathway: BCL2L1
hsa04730__30	6.08541501534747e-14	DOWN	-7.5085431232493	2.07522591902684e-13	Long-term depression: C00025*
hsa04024__107 64	6.53045175967932e-14	UP	7.49929330110793	2.222956314572e-13	cAMP signaling pathway: NFKBIA NFKB1
hsa05142__64	6.76481661764266e-14	UP	7.49466839003725	2.29856969702542e-13	Chagas disease (American trypanosomiasis): CASP8
hsa04024__34	7.00744489304214e-14	UP	7.49004347896657	2.37243044216688e-13	cAMP signaling pathway: ATP2B1
hsa05132__20	7.00744489304214e-14	UP	7.49004347896657	2.37243044216688e-13	Salmonella infection: ACTB
hsa04670__18	7.51864534222609e-14	UP	7.48079365682521	2.53181623620839e-13	Leukocyte transendothelial migration: CDH5
hsa05031__11	7.51864534222609e-14	UP	7.48079365682521	2.53181623620839e-13	Amphetamine addiction: GRIN3A
hsa05031__54	7.51864534222609e-14	UP	7.48079365682521	2.53181623620839e-13	Amphetamine addiction: GRIN3A*
hsa04062__33	8.06645939498229e-14	UP	7.47154383468385	2.70658521485209e-13	Chemokine signaling pathway: WAS
hsa04151__63	8.06645939498229e-14	DOWN	-7.47154383468385	2.70658521485209e-13	PI3K-Akt signaling pathway: CASP9
hsa05140__21	8.35489353781789e-14	UP	7.46691892361317	2.79836808512653e-13	Leishmaniasis: NFKB1
hsa04970__12	8.948008953911e-14	DOWN	-7.45766910147181	2.99121635641525e-13	Salivary secretion: BEST2
hsa05205__195	8.96250563417661e-14	UP	7.45766910147181	2.99121635641525e-13	Proteoglycans in cancer: CDKN1A
hsa04015__30	9.95620175177941e-14	UP	7.44379436825977	3.30524789604126e-13	Rap1 signaling pathway: ITGAL
hsa04622__6	9.95620175177941e-14	UP	7.44379436825977	3.30524789604126e-13	RIG-I-like receptor signaling pathway: NFKB1
hsa04960__4	9.95620175177941e-14	DOWN	-7.44379436825977	3.30524789604126e-13	Aldosterone-regulated sodium reabsorption: ATP1B4
hsa04970__32	1.03109060275671e-13	DOWN	-7.43916945718909	3.41696515446181e-13	Salivary secretion: RYR3
hsa04064__115	1.06780224985516e-13	UP	7.43454454611841	3.52618704301905e-13	NF-kappa B signaling pathway: XIAP
hsa05130__28	1.06780224985516e-13	UP	7.43454454611841	3.52618704301905e-13	Pathogenic Escherichia coli infection: ROCK1
hsa04261__73	1.10579773784435e-13	DOWN	-7.42991963504773	3.64525254282374e-13	Adrenergic signaling in cardiomyocytes: KCNE1
hsa04115__34	1.14512112272301e-13	UP	7.42529472397705	3.761682848945e-13	p53 signaling pathway: ZMAT3
hsa04530__14 20 43	1.14512112272301e-13	DOWN	-7.42529472397705	3.761682848945e-13	Tight junction: CTNNA1 ACTB ACTN4
hsa04211__52	1.18581794239552e-13	UP	7.42066981290637	3.88857227532493e-13	Longevity regulating pathway - mammal: PPARG
hsa04510__6 4 5	1.22793526547319e-13	UP	7.41604490183569	4.00571243719468e-13	Focal adhesion: FLNA ITGB1 ITGA11
hsa04510__26 4 5	1.22793526547319e-13	UP	7.41604490183569	4.00571243719468e-13	Focal adhesion: ACTN4 ITGB1 ITGA11
hsa05133__30	1.22793526547319e-13	UP	7.41604490183569	4.00571243719468e-13	Pertussis: NOS2
hsa04931__104	1.27152174164678e-13	UP	7.41141999076501	4.14070944983414e-13	Insulin resistance: C00369*
hsa04380__68	1.41160740545056e-13	UP	7.39754525755297	4.57312123248553e-13	Osteoclast differentiation: TGFBR1
hsa04922__78	1.41160740545056e-13	DOWN	-7.39754525755297	4.57312123248553e-13	Glucagon signaling pathway: ACACA
hsa05161__227	1.41160740545056e-13	UP	7.39754525755297	4.57312123248553e-13	Hepatitis B: MYD88*
hsa04670__35	1.46159046773318e-13	UP	7.39292034648229	4.71068351435787e-13	Leukocyte transendothelial migration: PTK2
hsa04916__9	1.46159046773318e-13	UP	7.39292034648229	4.71068351435787e-13	Melanogenesis: PRKACA
hsa05160__77	1.46159046773318e-13	UP	7.39292034648229	4.71068351435787e-13	Hepatitis C: NFKB1*
hsa04115__11 12	1.5668298720376e-13	UP	7.38367052434093	5.03260398215153e-13	p53 signaling pathway: CDK2 CCNE1
hsa04668__48	1.5668298720376e-13	UP	7.38367052434093	5.03260398215153e-13	TNF signaling pathway: CASP3
hsa04919__26	1.62220677287341e-13	DOWN	-7.37904561327025	5.20158110278009e-13	Thyroid hormone signaling pathway: THRB
hsa04062__35 36 37	1.67950554693564e-13	UP	7.37442070219957	5.36699136512257e-13	Chemokine signaling pathway: PARD3 PRKCZ TIAM1
hsa04071__1	1.67950554693564e-13	UP	7.37442070219957	5.36699136512257e-13	Sphingolipid signaling pathway: MAPK1
hsa05120__50	1.73879162532647e-13	UP	7.36979579112889	5.54701097451346e-13	Epithelial cell signaling in Helicobacter pylori infection: EGFR
hsa04917__46	1.80013262201811e-13	DOWN	-7.36517088005821	5.73296474029159e-13	Prolactin signaling pathway: GCK
hsa04660__44	1.86359840512379e-13	UP	7.36054596898753	5.92504467551202e-13	T cell receptor signaling pathway: PAK4
hsa05205__109	2.06747852710293e-13	UP	7.34667123577549	6.56214890612569e-13	Proteoglycans in cancer: SMAD2
hsa04010__61	2.14018984364597e-13	UP	7.34204632470481	6.77006181180265e-13	MAPK signaling pathway: ATF4
hsa05200__204	2.14018984364597e-13	UP	7.34204632470481	6.77006181180265e-13	Pathways in cancer: TGFB1*
hsa04062__25	2.21541175697704e-13	UP	7.33742141363413	6.98449444859036e-13	Chemokine signaling pathway: ROCK1
hsa04976__16	2.21541175697704e-13	DOWN	-7.33742141363413	6.98449444859036e-13	Bile secretion: CFTR
hsa04064__53	2.37373028313636e-13	UP	7.32817159149277	7.47108744055814e-13	NF-kappa B signaling pathway: CXCL8
hsa04972__42	2.45700549417912e-13	DOWN	-7.32354668042209	7.70736781896922e-13	Pancreatic secretion: CFTR
hsa05205__17	2.45700549417912e-13	UP	7.32354668042209	7.70736781896922e-13	Proteoglycans in cancer: AKT3
hsa04012__25	2.5431486844849e-13	UP	7.31892176935141	7.91155029494558e-13	ErbB signaling pathway: CDKN1B
hsa04062__44	2.5431486844849e-13	UP	7.31892176935141	7.91155029494558e-13	Chemokine signaling pathway: MAPK1
hsa04261__34	2.5431486844849e-13	UP	7.31892176935141	7.91155029494558e-13	Adrenergic signaling in cardiomyocytes: AKT3
hsa05130__9	2.5431486844849e-13	UP	7.31892176935141	7.91155029494558e-13	Pathogenic Escherichia coli infection: TLR4
hsa05205__34	2.5431486844849e-13	UP	7.31892176935141	7.91155029494558e-13	Proteoglycans in cancer: SLC9A1
hsa04360__21	2.63225672058474e-13	DOWN	-7.31429685828073	8.1482872783834e-13	Axon guidance: PAK4
hsa04370__23	2.63225672058474e-13	UP	7.31429685828073	8.1482872783834e-13	VEGF signaling pathway: PTK2
hsa05131__12	2.63225672058474e-13	UP	7.31429685828073	8.1482872783834e-13	Shigellosis: ARPC5
hsa05110__50	2.72407639961303e-13	DOWN	-7.30967194721005	8.40591684282401e-13	Vibrio cholerae infection: ACTB
hsa05152__82	2.72442967391156e-13	UP	7.30967194721005	8.40591684282401e-13	Tuberculosis: IL6
hsa04924__23	2.81977092453811e-13	UP	7.30504703613937	8.68581896263461e-13	Renin secretion: ITPR1
hsa04110__10 11 12 13 14 9 15 16 17 18 19 20	2.91838726819486e-13	UP	7.30042212506869	8.93102553247255e-13	Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
hsa05110__14	2.91838726819486e-13	DOWN	-7.30042212506869	8.93102553247255e-13	Vibrio cholerae infection: C00238*
hsa05110__15	2.91838726819486e-13	DOWN	-7.30042212506869	8.93102553247255e-13	Vibrio cholerae infection: C01330
hsa05110__16	2.91838726819486e-13	DOWN	-7.30042212506869	8.93102553247255e-13	Vibrio cholerae infection: C00698
hsa04261__66	3.02038902666946e-13	UP	7.29579721399801	9.19823497749095e-13	Adrenergic signaling in cardiomyocytes: C01245
hsa04670__73	3.02038902666946e-13	UP	7.29579721399801	9.19823497749095e-13	Leukocyte transendothelial migration: MYL12B*
hsa05162__20	3.02038902666946e-13	UP	7.29579721399801	9.19823497749095e-13	Measles: NFKB1
hsa05200__80	3.12589016169149e-13	UP	7.29117230292733	9.50412235245682e-13	Pathways in cancer: TP53
hsa04152__52	3.23500839241014e-13	DOWN	-7.28654739185665	9.80416253119137e-13	AMPK signaling pathway: PCK1
hsa05152__69	3.23500839241014e-13	UP	7.28654739185665	9.80416253119137e-13	Tuberculosis: HLA-DMA
hsa04931__40	3.46458653553449e-13	DOWN	-7.27729756971529	1.04661705792111e-12	Insulin resistance: PRKCZ
hsa05030__77	3.46458653553449e-13	UP	7.27729756971529	1.04661705792111e-12	Cocaine addiction: BDNF
hsa04151__103	3.5853017831679e-13	UP	7.27267265864461	1.07961250810456e-12	PI3K-Akt signaling pathway: BCL2*
hsa04722__84	3.5853017831679e-13	UP	7.27267265864461	1.07961250810456e-12	Neurotrophin signaling pathway: NFKB1*
hsa05130__26	3.8392547647344e-13	DOWN	-7.26342283650324	1.15423355246975e-12	Pathogenic Escherichia coli infection: CTNNB1
hsa04662__35	3.97277384699514e-13	UP	7.25879792543256	1.19246678250861e-12	B cell receptor signaling pathway: CD79B
hsa04020__18	4.25309284479238e-13	UP	7.2495481032912	1.26065948807401e-12	Calcium signaling pathway: C00002
hsa04020__17	4.25309284479238e-13	UP	7.2495481032912	1.26065948807401e-12	Calcium signaling pathway: C00004
hsa04020__15	4.25309284479238e-13	UP	7.2495481032912	1.26065948807401e-12	Calcium signaling pathway: C13051
hsa05020__24	4.25336417765826e-13	DOWN	-7.2495481032912	1.26065948807401e-12	Prion diseases: PRNP*
hsa05020__26	4.25336417765826e-13	DOWN	-7.2495481032912	1.26065948807401e-12	Prion diseases: PRNP**
hsa05020__25 8	4.25336417765826e-13	DOWN	-7.2495481032912	1.26065948807401e-12	Prion diseases: PRNP PRNP*
hsa05020__10 34	4.25336417765826e-13	DOWN	-7.2495481032912	1.26065948807401e-12	Prion diseases: PRNP PRNP***
hsa05211__45	4.25363552655093e-13	UP	7.2495481032912	1.26065948807401e-12	Renal cell carcinoma: ETS1
hsa04550__17	4.40128807337553e-13	UP	7.24492319222052	1.30031765564035e-12	Signaling pathways regulating pluripotency of stem cells: AKT3
hsa04910__20	4.40128807337553e-13	DOWN	-7.24492319222052	1.30031765564035e-12	Insulin signaling pathway: PKLR
hsa04390__96	4.55397021092594e-13	DOWN	-7.24029828114984	1.34331397587596e-12	Hippo signaling pathway: FGF1
hsa05205__256	4.87510054685072e-13	UP	7.23104845900848	1.43578588205839e-12	Proteoglycans in cancer: ACTB
hsa05205__233 234	5.21843708168641e-13	UP	7.22179863686712	1.5344981653347e-12	Proteoglycans in cancer: ITGA2 C00925
hsa04014__58 59	5.58548397122832e-13	UP	7.21254881472576	1.63730489577816e-12	Ras signaling pathway: STK4 STK4
hsa05014__5	5.58548397122832e-13	UP	7.21254881472576	1.63730489577816e-12	Amyotrophic lateral sclerosis (ALS): TOMM40
hsa04071__68	5.77839592961732e-13	UP	7.20792390365508	1.68334975996139e-12	Sphingolipid signaling pathway: NFKB1
hsa04390__77	5.77839592961732e-13	UP	7.20792390365508	1.68334975996139e-12	Hippo signaling pathway: CCND1
hsa04912__14	5.77839592961732e-13	UP	7.20792390365508	1.68334975996139e-12	GnRH signaling pathway: ATF4
hsa05168__92 93	5.77839592961732e-13	UP	7.20792390365508	1.68334975996139e-12	Herpes simplex infection: IRF9 STAT1
hsa04360__51	6.18404844207993e-13	UP	7.19867408151372	1.79873483323037e-12	Axon guidance: FYN
hsa04115__19	6.39723027978304e-13	UP	7.19404917044304	1.85786641355677e-12	p53 signaling pathway: RFWD2
hsa04650__15	6.61762201622466e-13	UP	7.18942425937236	1.91594942503638e-12	Natural killer cell mediated cytotoxicity: TNF
hsa04923__16	6.61762201622466e-13	UP	7.18942425937236	1.91594942503638e-12	Regulation of lipolysis in adipocytes: PLIN1
hsa04726__45	6.84546261968083e-13	UP	7.18479934830168	1.97886527113543e-12	Serotonergic synapse: TRPC1
hsa05142__21	7.0809988111095e-13	UP	7.180174437231	2.03754927504973e-12	Chagas disease (American trypanosomiasis): TICAM1
hsa05200__225	7.0809988111095e-13	UP	7.180174437231	2.03754927504973e-12	Pathways in cancer: PPARD
hsa05221__11	7.0809988111095e-13	UP	7.180174437231	2.03754927504973e-12	Acute myeloid leukemia: PPARD
hsa04621__28	7.32448530999327e-13	UP	7.17554952616032	2.10438958677024e-12	NOD-like receptor signaling pathway: CASP8
hsa03320__23	7.83636962921875e-13	UP	7.16629970401896	2.24802115012245e-12	PPAR signaling pathway: ACADL
hsa04931__47	8.10531920162378e-13	DOWN	-7.16167479294828	2.32163030180657e-12	Insulin resistance: AKT2*
hsa05321__92	8.38332313264761e-13	UP	7.1570498818776	2.39760489592768e-12	Inflammatory bowel disease (IBD): IL17F
hsa04210__99	8.67068009647529e-13	UP	7.15242497080692	2.47601943788405e-12	Apoptosis: BID**
hsa05200__203	8.96769840890038e-13	UP	7.14780005973624	2.55695072994292e-12	Pathways in cancer: TGFA*
hsa05152__97	9.27469633147915e-13	UP	7.14317514866556	2.64047794043172e-12	Tuberculosis: IL18
hsa04621__4 7 8	1.02589062137389e-12	DOWN	-7.12930041545352	2.91626093428372e-12	NOD-like receptor signaling pathway: IKBKG CHUK IKBKB
hsa04921__67	1.06092152852804e-12	UP	7.12467550438284	3.01128633248366e-12	Oxytocin signaling pathway: RYR1
hsa05160__71	1.17320828497518e-12	DOWN	-7.1108007711708	3.31497498867423e-12	Hepatitis C: MAPK8
hsa05161__195	1.17320828497518e-12	UP	7.1108007711708	3.31497498867423e-12	Hepatitis B: IL6
hsa05210__16	1.17320828497518e-12	UP	7.1108007711708	3.31497498867423e-12	Colorectal cancer: MAPK8
hsa04750__59	1.21316766116446e-12	UP	7.10617586010012	3.42273578878082e-12	Inflammatory mediator regulation of TRP channels: TRPV2
hsa05150__66	1.25446169460269e-12	UP	7.10155094902944	3.5339333195779e-12	Staphylococcus aureus infection: IL10
hsa05164__90	1.29713405055098e-12	DOWN	-7.09692603795876	3.64867497153488e-12	Influenza A: MAPK1
hsa05140__43	1.34122979179302e-12	UP	7.09230112688808	3.76144892355087e-12	Leishmaniasis: MAPK14
hsa05205__183	1.34122979179302e-12	UP	7.09230112688808	3.76144892355087e-12	Proteoglycans in cancer: VEGFA*
hsa05152__76	1.38679542232656e-12	UP	7.0876762158174	3.88344053435412e-12	Tuberculosis: TNF*
hsa04012__48	1.43387893238709e-12	UP	7.08305130474672	3.99149409474865e-12	ErbB signaling pathway: CAMK2A
hsa04621__43	1.43387893238709e-12	UP	7.08305130474672	3.99149409474865e-12	NOD-like receptor signaling pathway: MAPK1
hsa04810__21 82	1.43387893238709e-12	UP	7.08305130474672	3.99149409474865e-12	Regulation of actin cytoskeleton: CFL1 ACTB
hsa05016__22 9	1.43387893238709e-12	DOWN	-7.08305130474672	3.99149409474865e-12	Huntington's disease: DLG4 HTT
hsa04912__33	1.48252984484284e-12	UP	7.07842639367604	4.12081890304688e-12	GnRH signaling pathway: ELK1
hsa04340__50	1.53279926300224e-12	UP	7.07380148260536	4.24797907843835e-12	Hedgehog signaling pathway: BCL2
hsa05030__69	1.53279926300224e-12	UP	7.07380148260536	4.24797907843835e-12	Cocaine addiction: PRKACA**
hsa04210__31 32 33	1.58473991987519e-12	UP	7.06917657153468	4.37257901533844e-12	Apoptosis: TRAF2 RIPK1 TRADD
hsa05152__126	1.58473991987519e-12	UP	7.06917657153468	4.37257901533844e-12	Tuberculosis: NOS2
hsa05212__12	1.58473991987519e-12	DOWN	-7.06917657153468	4.37257901533844e-12	Pancreatic cancer: CASP9
hsa04932__55	1.63840622893152e-12	UP	7.064551660464	4.51402537267203e-12	Non-alcoholic fatty liver disease (NAFLD): CASP3
hsa04261__15 17	1.69385433640069e-12	DOWN	-7.05992674939332	4.65995944084464e-12	Adrenergic signaling in cardiomyocytes: ACTC1 MYH6
hsa04211__62	1.75114217515846e-12	UP	7.05530183832264	4.80349802499671e-12	Longevity regulating pathway - mammal: EHMT2
hsa04540__16 17	1.75114217515846e-12	UP	7.05530183832264	4.80349802499671e-12	Gap junction: GJA1 GJA1**
hsa04068__46	1.8103295202472e-12	UP	7.05067692725196	4.95861394831559e-12	FoxO signaling pathway: PLK4
hsa04010__86	1.87147804607814e-12	UP	7.04605201618128	5.10378410534228e-12	MAPK signaling pathway: MAP4K2
hsa04062__22 41	1.87147804607814e-12	UP	7.04605201618128	5.10378410534228e-12	Chemokine signaling pathway: CRK PTK2B
hsa05014__33 34	1.87147804607814e-12	UP	7.04605201618128	5.10378410534228e-12	Amyotrophic lateral sclerosis (ALS): NEFH PRPH
hsa04550__22	1.93465138536502e-12	UP	7.0414271051106	5.26842022188531e-12	Signaling pathways regulating pluripotency of stem cells: SMAD2
hsa04670__14	1.9999151898403e-12	UP	7.03680219403992	5.43826431506502e-12	Leukocyte transendothelial migration: SIPA1
hsa04530__11 33	2.06733719280623e-12	DOWN	-7.03217728296924	5.6053774679407e-12	Tight junction: TJP1 CGN
hsa05134__10	2.06733719280623e-12	UP	7.03217728296924	5.6053774679407e-12	Legionellosis: NFKB1
hsa04630__34	2.13698727357468e-12	DOWN	-7.02755237189855	5.77755264323285e-12	Jak-STAT signaling pathway: AOX1
hsa04961__13	2.13698727357468e-12	DOWN	-7.02755237189855	5.77755264323285e-12	Endocrine and other factor-regulated calcium reabsorption: ATP2B1
hsa04728__74	2.20893752385135e-12	UP	7.02292746082787	5.96349656223662e-12	Dopaminergic synapse: GRIN2A
hsa04350__32	2.28326231612136e-12	UP	7.01830254975719	6.15530830988813e-12	TGF-beta signaling pathway: RPS6KB1
hsa04064__130	2.36003837409483e-12	UP	7.01367763868651	6.34408026455535e-12	NF-kappa B signaling pathway: TNF*
hsa04530__11 24 23	2.36003837409483e-12	UP	7.01367763868651	6.34408026455535e-12	Tight junction: TJP1 YBX3 CDK4
hsa05222__40	2.43934484527296e-12	UP	7.00905272761583	6.54789852038271e-12	Small cell lung cancer: TRAF1
hsa05034__61	2.52126337569639e-12	UP	7.00442781654515	6.75813678021899e-12	Alcoholism: CRH
hsa04024__25	2.6058781869401e-12	DOWN	-6.99980290547447	6.9650712848655e-12	cAMP signaling pathway: CFTR
hsa04932__56	2.6058781869401e-12	UP	6.99980290547447	6.9650712848655e-12	Non-alcoholic fatty liver disease (NAFLD): CASP7
hsa05200__222	2.69327615542007e-12	UP	6.99517799440379	7.18844587504874e-12	Pathways in cancer: CASP9*
hsa04742__54	2.78057249566093e-12	UP	6.99055308333311	7.37698817203852e-12	Taste transduction: P2RX2*
hsa04742__40	2.78057249566093e-12	UP	6.99055308333311	7.37698817203852e-12	Taste transduction: P2RX2
hsa04621__6	2.78354689407946e-12	UP	6.99055308333311	7.37698817203852e-12	NOD-like receptor signaling pathway: NFKB1
hsa04912__19	2.78354689407946e-12	UP	6.99055308333311	7.37698817203852e-12	GnRH signaling pathway: MAPK7
hsa05168__9	2.78354689407946e-12	UP	6.99055308333311	7.37698817203852e-12	Herpes simplex infection: NFKB1
hsa04932__14	2.87678283652355e-12	DOWN	-6.98592817226243	7.61334499975739e-12	Non-alcoholic fatty liver disease (NAFLD): PKLR
hsa04921__48	2.97307932367502e-12	UP	6.98130326119175	7.85712524498646e-12	Oxytocin signaling pathway: PRKAG2
hsa04914__29	3.07235291861544e-12	UP	6.97667835012107	8.09718469591842e-12	Progesterone-mediated oocyte maturation: CDK2
hsa04530__20 22	3.0725346930228e-12	DOWN	-6.97667835012107	8.09718469591842e-12	Tight junction: ACTB MYL12B
hsa04620__18	3.17525037053992e-12	UP	6.97205343905039	8.35615608717719e-12	Toll-like receptor signaling pathway: CXCL11
hsa04066__26	3.28133096534812e-12	UP	6.96742852797971	8.61120235180046e-12	HIF-1 signaling pathway: C01245
hsa04210__59	3.28133096534812e-12	UP	6.96742852797971	8.61120235180046e-12	Apoptosis: PMAIP1
hsa04360__29	3.62085815972333e-12	UP	6.95355379476767	9.47575554612831e-12	Axon guidance: RASA1
hsa05205__238	3.62085815972333e-12	UP	6.95355379476767	9.47575554612831e-12	Proteoglycans in cancer: ITGAV*
hsa04071__59 60	3.74151165174521e-12	UP	6.94892888369699	9.77788650017976e-12	Sphingolipid signaling pathway: TP53 BCL2
hsa05231__50	3.86610436966879e-12	UP	6.94430397262631	1.00894584869551e-11	Choline metabolism in cancer: WASF2
hsa04390__94	4.12761485342023e-12	UP	6.93505415048495	1.07420890714357e-11	Hippo signaling pathway: GLI2
hsa05205__318	4.12761485342023e-12	UP	6.93505415048495	1.07420890714357e-11	Proteoglycans in cancer: HSPB2
hsa04510__24 69	4.26479624830478e-12	UP	6.93042923941427	1.10837512455943e-11	Focal adhesion: ZYX ACTB
hsa04742__55	4.40567349665051e-12	UP	6.92580432834359	1.13732266092681e-11	Taste transduction: P2RX3
hsa04270__48	4.40644437016881e-12	UP	6.92580432834359	1.13732266092681e-11	Vascular smooth muscle contraction: KCNMB2*
hsa04340__51	4.40644437016881e-12	UP	6.92580432834359	1.13732266092681e-11	Hedgehog signaling pathway: CCND1*
hsa04910__24	4.40644437016881e-12	DOWN	-6.92580432834359	1.13732266092681e-11	Insulin signaling pathway: ACACA
hsa05161__97	4.40644437016881e-12	UP	6.92580432834359	1.13732266092681e-11	Hepatitis B: BCL2
hsa04390__14	4.552701530484e-12	UP	6.92117941727291	1.1718529007917e-11	Hippo signaling pathway: AREG
hsa05205__103	4.552701530484e-12	UP	6.92117941727291	1.1718529007917e-11	Proteoglycans in cancer: CCND1
hsa04912__15	5.02061762171818e-12	UP	6.90730468406087	1.28700416251139e-11	GnRH signaling pathway: CAMK2A
hsa04917__45	5.02061762171818e-12	DOWN	-6.90730468406087	1.28700416251139e-11	Prolactin signaling pathway: SLC2A2
hsa05134__7	5.02061762171818e-12	UP	6.90730468406087	1.28700416251139e-11	Legionellosis: IL18
hsa04922__70	5.53557924290466e-12	DOWN	-6.89342995084883	1.41707811953922e-11	Glucagon signaling pathway: PFKFB1
hsa04012__21	5.71847399658184e-12	UP	6.88880503977815	1.46190648157514e-11	ErbB signaling pathway: GSK3B
hsa05220__21	5.90728758617556e-12	UP	6.88418012870747	1.50812409978585e-11	Chronic myeloid leukemia: NFKBIA
hsa04010__57	6.10220738758783e-12	UP	6.87955521763679	1.55366499746308e-11	MAPK signaling pathway: NLK
hsa04976__59	6.10220738758783e-12	UP	6.87955521763679	1.55366499746308e-11	Bile secretion: ABCB4
hsa05010__49	6.30342657099577e-12	UP	6.87493030656611	1.60272510512869e-11	Alzheimer's disease: EIF2AK3
hsa04623__8	6.51114427557831e-12	UP	6.87030539549543	1.64662719970547e-11	Cytosolic DNA-sensing pathway: TBK1
hsa04950__21	6.51114427557831e-12	DOWN	-6.87030539549543	1.64662719970547e-11	Maturity onset diabetes of the young: PKLR
hsa05200__121 122	6.51114427557831e-12	UP	6.87030539549543	1.64662719970547e-11	Pathways in cancer: SMAD2 SMAD4
hsa05212__38 39	6.51114427557831e-12	UP	6.87030539549543	1.64662719970547e-11	Pancreatic cancer: SMAD2 SMAD4
hsa05168__106 134	6.72556578937047e-12	DOWN	-6.86568048442475	1.69401315257736e-11	Herpes simplex infection: SRSF8 C1QBP
hsa05169__29	6.72556578937047e-12	UP	6.86568048442475	1.69401315257736e-11	Epstein-Barr virus infection: FCER2
hsa05200__217	6.72556578937047e-12	UP	6.86568048442475	1.69401315257736e-11	Pathways in cancer: E2F1*
hsa04350__44 45	6.94690273439166e-12	UP	6.86105557335407	1.74508425640668e-11	TGF-beta signaling pathway: TGFBR2 TGFBR1
hsa04662__24	6.94690273439166e-12	UP	6.86105557335407	1.74508425640668e-11	B cell receptor signaling pathway: FOS
hsa04072__57	7.41120222501349e-12	UP	6.85180575121271	1.85923217367161e-11	Phospholipase D signaling pathway: C06124
hsa04722__37	7.65462142759723e-12	DOWN	-6.84718084014203	1.91773782166069e-11	Neurotrophin signaling pathway: NFKB1
hsa04970__39	7.9054195481314e-12	UP	6.84255592907135	1.97793386563767e-11	Salivary secretion: KCNN4
hsa03320__25	8.43284658534264e-12	DOWN	-6.83330610692999	2.1042919965284e-11	PPAR signaling pathway: EHHADH
hsa04022__9	8.43284658534264e-12	UP	6.83330610692999	2.1042919965284e-11	cGMP-PKG signaling pathway: ITPR1
hsa04666__51	8.70909047578414e-12	UP	6.82868119585931	2.16460066190455e-11	Fc gamma R-mediated phagocytosis: NCF1
hsa04933__61	8.70909047578414e-12	UP	6.82868119585931	2.16460066190455e-11	AGE-RAGE signaling pathway in diabetic complications: MMP2
hsa05213__13	8.70909047578414e-12	DOWN	-6.82868119585931	2.16460066190455e-11	Endometrial cancer: CASP9
hsa04310__31	8.99419487568238e-12	DOWN	-6.82405628478863	2.23250887336951e-11	Wnt signaling pathway: MMP7
hsa04650__40	9.90549300428294e-12	UP	6.81018155157659	2.45546455871341e-11	Natural killer cell mediated cytotoxicity: TNFRSF10D
hsa04022__46	1.0562654500627e-11	UP	6.80093172943523	2.61147734298397e-11	cGMP-PKG signaling pathway: VASP
hsa04720__4 15	1.0562654500627e-11	UP	6.80093172943523	2.61147734298397e-11	Long-term potentiation: CREBBP ATF4
hsa04014__68	1.09070649097686e-11	UP	6.79630681836455	2.69308475235942e-11	Ras signaling pathway: RALGDS*
hsa04933__30	1.12624690481058e-11	UP	6.79168190729387	2.7771888899463e-11	AGE-RAGE signaling pathway in diabetic complications: CXCL8
hsa04921__56	1.16292099956423e-11	UP	6.78705699622318	2.86011591384973e-11	Oxytocin signaling pathway: JUN
hsa05030__78	1.16292099956423e-11	DOWN	-6.78705699622318	2.86011591384973e-11	Cocaine addiction: GRIA2
hsa05205__422	1.20076412833581e-11	UP	6.7824320851525	2.94932783940261e-11	Proteoglycans in cancer: CD63
hsa03320__61	1.23981272034162e-11	DOWN	-6.77780717408182	3.04126384010693e-11	PPAR signaling pathway: APOA1
hsa04210__84	1.28010431283216e-11	UP	6.77318226301114	3.1360052200934e-11	Apoptosis: FAS**
hsa04152__49	1.32167758392848e-11	UP	6.76855735194046	3.23363565130417e-11	AMPK signaling pathway: GYS1
hsa04015__92	1.36449641617524e-11	UP	6.76393244086978	3.32991105721291e-11	Rap1 signaling pathway: C00076*
hsa04064__128	1.36457238640444e-11	UP	6.76393244086978	3.32991105721291e-11	NF-kappa B signaling pathway: IL1B*
hsa05223__8	1.40882978244173e-11	DOWN	-6.7593075297991	3.43345157095721e-11	Non-small cell lung cancer: CASP9
hsa05211__48	1.45449207938435e-11	UP	6.75468261872842	3.54014328648082e-11	Renal cell carcinoma: JUN
hsa04152__53	1.50160286652077e-11	DOWN	-6.75005770765774	3.65007993039136e-11	AMPK signaling pathway: G6PC
hsa04014__66	1.60035090636637e-11	DOWN	-6.74080788551638	3.88508960343979e-11	Ras signaling pathway: RAF1*
hsa04662__29	1.70544972041271e-11	UP	6.73155806337502	4.12956188744264e-11	B cell receptor signaling pathway: RAC1
hsa04915__66	1.70544972041271e-11	UP	6.73155806337502	4.12956188744264e-11	Estrogen signaling pathway: AKT3*
hsa04014__26	1.76050437622666e-11	DOWN	-6.72693315230434	4.25738445679523e-11	Ras signaling pathway: PRKCA
hsa04115__22	1.81729817544863e-11	UP	6.72230824123366	4.38907875535728e-11	p53 signaling pathway: STEAP3
hsa04015__3	1.93631956221263e-11	UP	6.7130584190923	4.65857164839632e-11	Rap1 signaling pathway: MAPK1
hsa04670__55	1.93631956221263e-11	UP	6.7130584190923	4.65857164839632e-11	Leukocyte transendothelial migration: RAC2
hsa04933__12	1.93631956221263e-11	UP	6.7130584190923	4.65857164839632e-11	AGE-RAGE signaling pathway in diabetic complications: EGR1
hsa04211__39	1.99865941820916e-11	UP	6.70843350802162	4.79627209044062e-11	Longevity regulating pathway - mammal: TP53*
hsa04610__45	1.99865941820916e-11	UP	6.70843350802162	4.79627209044062e-11	Complement and coagulation cascades: C4A
hsa05222__32	2.06296305070477e-11	UP	6.70380859695094	4.94426986259472e-11	Small cell lung cancer: BIRC8
hsa05211__41	2.1292909021446e-11	UP	6.69918368588026	5.09025140601743e-11	Renal cell carcinoma: PDGFB*
hsa05220__19 41	2.1292909021446e-11	UP	6.69918368588026	5.09025140601743e-11	Chronic myeloid leukemia: SMAD4 SMAD3
hsa04914__11	2.19770522968896e-11	UP	6.69455877480958	5.2471259550007e-11	Progesterone-mediated oocyte maturation: CDK1
hsa04014__44	2.41611798586878e-11	UP	6.68068404159754	5.76127626325816e-11	Ras signaling pathway: ETS1
hsa03460__28	2.49353897233474e-11	UP	6.67605913052686	5.9233372048255e-11	Fanconi anemia pathway: RAD51C
hsa04062__8 41	2.49353897233474e-11	UP	6.67605913052686	5.9233372048255e-11	Chemokine signaling pathway: PXN PTK2B
hsa04660__41 46	2.49353897233474e-11	UP	6.67605913052686	5.9233372048255e-11	T cell receptor signaling pathway: GRAP2 LCP2
hsa05222__35	2.65573593764065e-11	UP	6.6668093083855	6.3006664480136e-11	Small cell lung cancer: NOS2
hsa04726__10	2.74066276295887e-11	DOWN	-6.66218439731482	6.47761676930782e-11	Serotonergic synapse: PRKACA
hsa04924__52	2.74066276295887e-11	UP	6.66218439731482	6.47761676930782e-11	Renin secretion: KCNJ2
hsa04971__49	2.74066276295887e-11	UP	6.66218439731482	6.47761676930782e-11	Gastric acid secretion: KCNJ1
hsa05222__39	2.82824614416479e-11	UP	6.65755948624414	6.6762242523689e-11	Small cell lung cancer: BCL2L1
hsa04660__40 41	2.91856724775987e-11	UP	6.65293457517346	6.88078777734102e-11	T cell receptor signaling pathway: LAT GRAP2
hsa04020__22	3.0117096584385e-11	DOWN	-6.64830966410278	7.07375306025743e-11	Calcium signaling pathway: C00575
hsa04722__50	3.0117096584385e-11	DOWN	-6.64830966410278	7.07375306025743e-11	Neurotrophin signaling pathway: RHOA
hsa05223__23	3.0117096584385e-11	DOWN	-6.64830966410278	7.07375306025743e-11	Non-small cell lung cancer: CASP9*
hsa04924__30	3.20680525345263e-11	DOWN	-6.63905984196142	7.52258061328026e-11	Renin secretion: PDE3A
hsa04911__56	3.41425268477186e-11	DOWN	-6.62981001982006	7.9694171362563e-11	Insulin secretion: CAMK2A*
hsa05200__49	3.41425268477186e-11	DOWN	-6.62981001982006	7.9694171362563e-11	Pathways in cancer: CASP9
hsa05205__434	3.41425268477186e-11	UP	6.62981001982006	7.9694171362563e-11	Proteoglycans in cancer: CASP3
hsa05223__24	3.41425268477186e-11	UP	6.62981001982006	7.9694171362563e-11	Non-small cell lung cancer: STK4
hsa04066__60	3.63481509649211e-11	UP	6.6205601976787	8.45274451275827e-11	HIF-1 signaling pathway: NOS3
hsa04360__3	3.63481509649211e-11	UP	6.6205601976787	8.45274451275827e-11	Axon guidance: GNAI1
hsa04950__18	3.63481509649211e-11	DOWN	-6.6205601976787	8.45274451275827e-11	Maturity onset diabetes of the young: SLC2A2
hsa04024__109	3.86930156420509e-11	UP	6.61131037553734	8.97582424585354e-11	cAMP signaling pathway: BDNF
hsa05215__30	3.86930156420509e-11	UP	6.61131037553734	8.97582424585354e-11	Prostate cancer: TP53
hsa04620__66	4.11856978251648e-11	UP	6.60206055339598	9.54228436664422e-11	Toll-like receptor signaling pathway: CASP8
hsa04520__9 57	4.24902906762206e-11	DOWN	-6.5974356423253	9.80826243005141e-11	Adherens junction: LEF1 CTNNB1
hsa04520__4	4.24902906762206e-11	DOWN	-6.5974356423253	9.80826243005141e-11	Adherens junction: CTNND1
hsa05162__81	4.24902906762206e-11	UP	6.5974356423253	9.80826243005141e-11	Measles: TNFRSF10D
hsa04621__21 31 41	4.81251160698312e-11	UP	6.57893599804258	1.10681876493529e-10	NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1
hsa04910__14	4.81251160698312e-11	DOWN	-6.57893599804258	1.10681876493529e-10	Insulin signaling pathway: C00369
hsa05131__38	4.81251160698312e-11	UP	6.57893599804258	1.10681876493529e-10	Shigellosis: CXCL8
hsa04917__33	4.96443194755211e-11	DOWN	-6.5743110869719	1.14036279088636e-10	Prolactin signaling pathway: CSN2
hsa04360__4	5.28247933554089e-11	UP	6.56506126483054	1.21193878772666e-10	Axon guidance: GNAI1*
hsa04530__30	5.62043145159407e-11	UP	6.55581144268918	1.28790130457869e-10	Tight junction: AKT3
hsa04725__61	5.79724869674116e-11	UP	6.5511865316185	1.32518616802636e-10	Cholinergic synapse: FOS
hsa05164__41 42	5.79724869674116e-11	UP	6.5511865316185	1.32518616802636e-10	Influenza A: STAT1 IRF9
hsa04010__120	5.97950329336477e-11	UP	6.54656162054781	1.36518671788972e-10	MAPK signaling pathway: NFATC1
hsa04068__40	6.16735842860459e-11	UP	6.54193670947713	1.40466260452703e-10	FoxO signaling pathway: CCND1
hsa05162__44	6.16735842860459e-11	UP	6.54193670947713	1.40466260452703e-10	Measles: PRKCQ
hsa05205__158	6.36098206094418e-11	UP	6.53731179840645	1.44700790466273e-10	Proteoglycans in cancer: PDCD4
hsa04010__68	6.7662313250578e-11	UP	6.52806197626509	1.53362468754929e-10	MAPK signaling pathway: ATF2
hsa04068__13	6.7662313250578e-11	DOWN	-6.52806197626509	1.53362468754929e-10	FoxO signaling pathway: PCK1
hsa04932__7	6.7662313250578e-11	UP	6.52806197626509	1.53362468754929e-10	Non-alcoholic fatty liver disease (NAFLD): SREBF1
hsa05152__6	7.19669542841641e-11	UP	6.51881215412373	1.627267233453e-10	Tuberculosis: IL10
hsa05166__34 35 36	7.19669542841641e-11	UP	6.51881215412373	1.627267233453e-10	HTLV-I infection: MYC TRRAP KAT5
hsa04722__35	7.42185762637151e-11	UP	6.51418724305305	1.6741501176413e-10	Neurotrophin signaling pathway: FOXO3
hsa05164__36	7.42185762637151e-11	UP	6.51418724305305	1.6741501176413e-10	Influenza A: IL33
hsa04014__69	8.39343322369703e-11	DOWN	-6.49568759877033	1.88877377572775e-10	Ras signaling pathway: PLCE1*
hsa04810__31	8.39343322369703e-11	UP	6.49568759877033	1.88877377572775e-10	Regulation of actin cytoskeleton: MSN
hsa04742__37	8.6511313884141e-11	UP	6.49106268769965	1.94443491373566e-10	Taste transduction: P2RY4
hsa05133__59	1.00880519611247e-10	UP	6.46793813234625	2.26468932317245e-10	Pertussis: C3
hsa04360__59	1.13990993998239e-10	UP	6.44943848806353	2.55595558141636e-10	Axon guidance: MAPK1*
hsa04620__19	1.17520495815616e-10	UP	6.44481357699285	2.63195484669299e-10	Toll-like receptor signaling pathway: CXCL10
hsa04066__48	1.21156744883231e-10	UP	6.44018866592217	2.71016099566179e-10	HIF-1 signaling pathway: PFKFB3
hsa04340__40	1.24902889565072e-10	UP	6.43556375485149	2.79063649813044e-10	Hedgehog signaling pathway: SUFU
hsa05161__194	1.45398709421921e-10	UP	6.41243919949809	3.24470516631579e-10	Hepatitis B: TNF*
hsa04014__35	1.49875584843521e-10	UP	6.40781428842741	3.3366851175471e-10	Ras signaling pathway: NFKB1
hsa04810__29	1.49875584843521e-10	UP	6.40781428842741	3.3366851175471e-10	Regulation of actin cytoskeleton: ACTN4
hsa04152__103	1.54487070973999e-10	UP	6.40318937735673	3.42716890625907e-10	AMPK signaling pathway: ULK1
hsa04923__43	1.54487070973999e-10	UP	6.40318937735673	3.42716890625907e-10	Regulation of lipolysis in adipocytes: C00219
hsa05215__8	1.54487070973999e-10	UP	6.40318937735673	3.42716890625907e-10	Prostate cancer: NFKBIA
hsa03320__37	1.64129771390681e-10	DOWN	-6.39393955521537	3.63679057126284e-10	PPAR signaling pathway: HMGCS2
hsa04014__103	1.69169218160242e-10	UP	6.38931464414469	3.74403958684447e-10	Ras signaling pathway: KSR2
hsa04933__26	1.79705772739624e-10	UP	6.38006482200333	3.96788656848124e-10	AGE-RAGE signaling pathway in diabetic complications: IL6
hsa05200__188	1.79705772739624e-10	UP	6.38006482200333	3.96788656848124e-10	Pathways in cancer: KLK3
hsa05014__53	1.85211836199586e-10	DOWN	-6.37543991093265	4.07987151487716e-10	Amyotrophic lateral sclerosis (ALS): RAB5A
hsa05134__6	1.85211836199586e-10	UP	6.37543991093265	4.07987151487716e-10	Legionellosis: IL1B
hsa04912__46	1.90882606859959e-10	UP	6.37081499986197	4.19986438278528e-10	GnRH signaling pathway: JUN
hsa04530__7 52	1.96722886813034e-10	DOWN	-6.36619008879129	4.32330180493206e-10	Tight junction: PARD6A MPP5
hsa04912__26	2.02737614334241e-10	UP	6.36156517772061	4.4502801090425e-10	GnRH signaling pathway: PLD1
hsa04620__39	2.0893186762979e-10	UP	6.35694026664993	4.5808982412646e-10	Toll-like receptor signaling pathway: IL6
hsa05200__196	2.15310868684102e-10	UP	6.35231535557925	4.71525783516815e-10	Pathways in cancer: TRAF1
hsa04668__20	2.28644744701392e-10	UP	6.34306553343789	5.00143743066257e-10	TNF signaling pathway: IKBKG
hsa04066__49	2.35610818599848e-10	UP	6.33844062236721	5.14184353251004e-10	HIF-1 signaling pathway: EPO
hsa04933__27	2.35610818599848e-10	UP	6.33844062236721	5.14184353251004e-10	AGE-RAGE signaling pathway in diabetic complications: TNF
hsa04380__38	2.501704308542e-10	UP	6.32919080022585	5.45325103915362e-10	Osteoclast differentiation: FOS
hsa04725__18	2.57776142841352e-10	UP	6.32456588915517	5.60603440276506e-10	Cholinergic synapse: ITPR1
hsa05145__8	2.57776142841352e-10	UP	6.32456588915517	5.60603440276506e-10	Toxoplasmosis: NFKB1
hsa04923__31	2.65607527621239e-10	UP	6.31994097808449	5.76967103352957e-10	Regulation of lipolysis in adipocytes: PRKACA*
hsa04660__34	2.90521876090283e-10	UP	6.30606624487244	6.28906227158573e-10	T cell receptor signaling pathway: FOS
hsa05160__56	2.90521876090283e-10	DOWN	-6.30606624487244	6.28906227158573e-10	Hepatitis C: MAPK1
hsa05213__11	2.90521876090283e-10	UP	6.30606624487244	6.28906227158573e-10	Endometrial cancer: FOXO3
hsa04550__62 63	3.17713402083132e-10	UP	6.2921915116604	6.86977540292526e-10	Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4
hsa04360__89	3.27317780610368e-10	DOWN	-6.28756660058972	7.06119529009048e-10	Axon guidance: CAMK2A
hsa05014__2	3.27317780610368e-10	UP	6.28756660058972	7.06119529009048e-10	Amyotrophic lateral sclerosis (ALS): SLC1A2
hsa04742__46	3.47384527786737e-10	UP	6.27831677844836	7.48549917100091e-10	Taste transduction: P2RY1
hsa04022__71	3.57863399276067e-10	UP	6.27369186737768	7.6936536297452e-10	cGMP-PKG signaling pathway: PPIF
hsa04917__37	3.57863399276067e-10	DOWN	-6.27369186737768	7.6936536297452e-10	Prolactin signaling pathway: TNFSF11
hsa04024__24	3.79755136196856e-10	UP	6.26444204523632	8.15497029615876e-10	cAMP signaling pathway: PLN
hsa04015__82	3.91185923805759e-10	UP	6.25981713416564	8.38128108131153e-10	Rap1 signaling pathway: ITGA2B
hsa04350__34	3.91185923805759e-10	UP	6.25981713416564	8.38128108131153e-10	TGF-beta signaling pathway: ROCK1
hsa04919__30	4.02952355828669e-10	DOWN	-6.25519222309496	8.62354756949965e-10	Thyroid hormone signaling pathway: MYH6
hsa04660__35	4.15064028788434e-10	UP	6.25056731202428	8.86256034197122e-10	T cell receptor signaling pathway: NFATC1
hsa04726__38	4.15064028788434e-10	DOWN	-6.25056731202428	8.86256034197122e-10	Serotonergic synapse: PLA2G4B
hsa04210__75	4.53570500577722e-10	UP	6.23669257881224	9.67376811107309e-10	Apoptosis: BAK1*
hsa04022__66	4.67164543041062e-10	DOWN	-6.23206766774156	9.9298888730108e-10	cGMP-PKG signaling pathway: PDE3A
hsa04024__12	4.67164543041062e-10	UP	6.23206766774156	9.9298888730108e-10	cAMP signaling pathway: SLC9A1
hsa04722__70	4.67164543041062e-10	DOWN	-6.23206766774156	9.9298888730108e-10	Neurotrophin signaling pathway: ZNF274
hsa05160__8	4.81155954233405e-10	UP	6.22744275667088	1.02157292429895e-09	Hepatitis C: NFKB1
hsa04115__27	5.25629046319822e-10	UP	6.21356802345884	1.11473699552477e-09	p53 signaling pathway: THBS1
hsa05034__84	5.57480420098771e-10	UP	6.20431820131748	1.18095344911566e-09	Alcoholism: FOSB
hsa04933__58	5.74104737797108e-10	UP	6.1996932902468	1.21480045306393e-09	AGE-RAGE signaling pathway in diabetic complications: CCL2
hsa04724__3	5.9121244078386e-10	DOWN	-6.19506837917612	1.24959299913709e-09	Glutamatergic synapse: GRIK1
hsa04210__50	6.26933093801019e-10	DOWN	-6.18581855703476	1.32063596777143e-09	Apoptosis: SPTA1
hsa05012__70	6.26933093801019e-10	UP	6.18581855703476	1.32063596777143e-09	Parkinson's disease: PRKACA
hsa05152__78	6.26933093801019e-10	UP	6.18581855703476	1.32063596777143e-09	Tuberculosis: IL1A
hsa04066__44	6.45574539085665e-10	UP	6.18119364596408	1.3583813649966e-09	HIF-1 signaling pathway: GAPDH
hsa04919__100	7.04802642055143e-10	DOWN	-6.16731891275204	1.47969180382303e-09	Thyroid hormone signaling pathway: CTNNB1*
hsa05219__27	7.04802642055143e-10	UP	6.16731891275204	1.47969180382303e-09	Bladder cancer: RPS6KA5
hsa04024__3	7.92079220857719e-10	UP	6.14881926846932	1.66106791963354e-09	cAMP signaling pathway: RYR2
hsa04930__9	8.15494815316553e-10	DOWN	-6.14419435739864	1.70826617389053e-09	Type II diabetes mellitus: C00238
hsa04150__56	8.39585080804425e-10	UP	6.13956944632796	1.75481687078033e-09	mTOR signaling pathway: EIF4B
hsa04310__13	8.39585080804425e-10	UP	6.13956944632796	1.75481687078033e-09	Wnt signaling pathway: NFATC1
hsa05014__49	8.64368926419553e-10	DOWN	-6.13494453525728	1.80461023638038e-09	Amyotrophic lateral sclerosis (ALS): C00001
hsa05168__91 92	8.89865775572033e-10	UP	6.1303196241866	1.85578001365133e-09	Herpes simplex infection: STAT1 IRF9
hsa04810__32	9.70836579735019e-10	UP	6.11644489097456	2.02239682186486e-09	Regulation of actin cytoskeleton: PXN
hsa04010__12	9.99390444464797e-10	DOWN	-6.11181997990388	2.07497750845232e-09	MAPK signaling pathway: PLA2G4B
hsa04340__52	9.99390444464797e-10	UP	6.11181997990388	2.07497750845232e-09	Hedgehog signaling pathway: BCL2*
hsa05030__37	9.99390444464797e-10	UP	6.11181997990388	2.07497750845232e-09	Cocaine addiction: PRKACA
hsa04115__64	1.02876263047943e-09	UP	6.1071950688332	2.13360373363229e-09	p53 signaling pathway: PMAIP1
hsa04022__45	1.05897594367359e-09	UP	6.10257015776252	2.19384321737892e-09	cGMP-PKG signaling pathway: CREB3
hsa04520__69	1.12202027426195e-09	UP	6.09332033562116	2.31933563843586e-09	Adherens junction: IQGAP1**
hsa04620__46	1.12202027426195e-09	UP	6.09332033562116	2.31933563843586e-09	Toll-like receptor signaling pathway: TNF
hsa05032__30	1.15484771494e-09	DOWN	-6.08869542455048	2.37944868028129e-09	Morphine addiction: ADORA1
hsa04071__24	1.15490005131269e-09	UP	6.08869542455048	2.37944868028129e-09	Sphingolipid signaling pathway: PTEN
hsa04620__29	1.15490005131269e-09	UP	6.08869542455048	2.37944868028129e-09	Toll-like receptor signaling pathway: CXCL8
hsa04071__65	1.18871850833739e-09	UP	6.0840705134798	2.44376594875926e-09	Sphingolipid signaling pathway: BAX*
hsa05133__94	1.18871850833739e-09	UP	6.0840705134798	2.44376594875926e-09	Pertussis: IL12A
hsa04340__15	1.22350169956193e-09	DOWN	-6.07944560240912	2.50704437674686e-09	Hedgehog signaling pathway: HHIP
hsa04620__77	1.22350169956193e-09	UP	6.07944560240912	2.50704437674686e-09	Toll-like receptor signaling pathway: CXCL9
hsa04912__17	1.22350169956193e-09	UP	6.07944560240912	2.50704437674686e-09	GnRH signaling pathway: MAPK14
hsa04630__31	1.25927638059819e-09	DOWN	-6.07482069133844	2.57473375314908e-09	Jak-STAT signaling pathway: BCL2L1
hsa05211__23	1.25927638059819e-09	UP	6.07482069133844	2.57473375314908e-09	Renal cell carcinoma: PDGFB
hsa05205__129	1.29607002670335e-09	UP	6.07019578026776	2.64420801321998e-09	Proteoglycans in cancer: AKT3*
hsa05211__46	1.29607002670335e-09	UP	6.07019578026776	2.64420801321998e-09	Renal cell carcinoma: AKT3
hsa04014__76	1.3728278261485e-09	DOWN	-6.06094595812639	2.79473833730557e-09	Ras signaling pathway: RALBP1*
hsa04540__12	1.3728278261485e-09	DOWN	-6.06094595812639	2.79473833730557e-09	Gap junction: C00025
hsa05110__46	1.41285069904169e-09	DOWN	-6.05632104705571	2.87310223322438e-09	Vibrio cholerae infection: PLCG1
hsa05166__53 146	1.49633714062458e-09	UP	6.04707122491435	3.03630398189373e-09	HTLV-I infection: CREB1 CRTC2
hsa05211__43	1.49633714062458e-09	UP	6.04707122491435	3.03630398189373e-09	Renal cell carcinoma: RAP1A
hsa04014__61	1.53986427611865e-09	UP	6.04244631384367	3.12125671502366e-09	Ras signaling pathway: RAP1A
hsa04921__53	1.58462448634717e-09	UP	6.03782140277299	3.2085230709551e-09	Oxytocin signaling pathway: RGS2
hsa04014__54	1.72664758960783e-09	UP	6.02394666956095	3.49232596434134e-09	Ras signaling pathway: RHOA
hsa04390__5	1.82814201052041e-09	DOWN	-6.01469684741959	3.69363315889016e-09	Hippo signaling pathway: SAV1
hsa05145__23	1.88104609716369e-09	UP	6.01007193634891	3.79643997483414e-09	Toxoplasmosis: CIITA
hsa04115__3	1.99136677533479e-09	UP	6.00082211420755	4.0147834451224e-09	p53 signaling pathway: GADD45G
hsa04530__11 62	2.04886604982967e-09	DOWN	-5.99619720313687	4.12186221373657e-09	Tight junction: TJP1 SHROOM1
hsa05200__193	2.04886604982967e-09	UP	5.99619720313687	4.12186221373657e-09	Pathways in cancer: NOS2
hsa04014__97	2.23123902645349e-09	UP	5.98232246992483	4.47438434440353e-09	Ras signaling pathway: PAK4
hsa05200__5	2.23123902645349e-09	DOWN	-5.98232246992483	4.47438434440353e-09	Pathways in cancer: CASP3*
hsa05210__7	2.23123902645349e-09	DOWN	-5.98232246992483	4.47438434440353e-09	Colorectal cancer: CASP3*
hsa04010__134	2.29547276079422e-09	UP	5.97769755885415	4.5982871189044e-09	MAPK signaling pathway: ATF4*
hsa04024__115	2.42938888878263e-09	UP	5.96844773671279	4.8613649861795e-09	cAMP signaling pathway: F2R
hsa03460__27	2.49917053917104e-09	UP	5.96382282564211	4.99568238627913e-09	Fanconi anemia pathway: BRCA1
hsa05152__23	2.57090293662959e-09	DOWN	-5.95919791457143	5.12815989164224e-09	Tuberculosis: PPP3CA
hsa05166__60	2.57090293662959e-09	DOWN	-5.95919791457143	5.12815989164224e-09	HTLV-I infection: POLD3
hsa04520__17	2.79834116778263e-09	UP	5.94532318135939	5.57000323544869e-09	Adherens junction: SNAI1
hsa04925__34	2.79834116778263e-09	DOWN	-5.94532318135939	5.57000323544869e-09	Aldosterone synthesis and secretion: STAR
hsa04919__39	2.87842021363173e-09	DOWN	-5.94069827028871	5.72333500678731e-09	Thyroid hormone signaling pathway: ESR1
hsa04022__57	2.96072906708793e-09	UP	5.93607335921803	5.88077158251397e-09	cGMP-PKG signaling pathway: C00144
hsa04510__44	3.13227889307695e-09	UP	5.92682353707667	6.21494407612629e-09	Focal adhesion: BCL2
hsa04024__114	3.70704811675611e-09	DOWN	-5.89907407065259	7.33987714582163e-09	cAMP signaling pathway: HHIP
hsa04726__72	3.70704811675611e-09	UP	5.89907407065259	7.33987714582163e-09	Serotonergic synapse: KCNJ3
hsa04915__28	3.81233577998898e-09	UP	5.89444915958191	7.54039887431504e-09	Estrogen signaling pathway: KCNJ3
hsa05164__35	4.03171487369625e-09	UP	5.88519933744055	7.96592244760806e-09	Influenza A: IL18
hsa05145__4 5	4.26336230525238e-09	UP	5.87594951529919	8.41476656677439e-09	Toxoplasmosis: MAP3K7 TAB1
hsa04010__65	4.5079432300625e-09	UP	5.86669969315783	8.87885254642289e-09	MAPK signaling pathway: ELK4
hsa04911__4	4.5079432300625e-09	UP	5.86669969315783	8.87885254642289e-09	Insulin secretion: CACNA1C
hsa04728__68	4.63530109867808e-09	UP	5.86207478208715	9.11059703390807e-09	Dopaminergic synapse: CACNA1C
hsa05205__140	4.63530109867808e-09	UP	5.86207478208715	9.11059703390807e-09	Proteoglycans in cancer: MAPK1***
hsa04068__52	4.76615766610139e-09	DOWN	-5.85744987101647	9.34823617390868e-09	FoxO signaling pathway: CAT
hsa04360__40 142	4.76615766610139e-09	UP	5.85744987101647	9.34823617390868e-09	Axon guidance: UNC5D PTPN11
hsa04071__57	5.1806640217689e-09	UP	5.84357513780443	1.01506441052177e-08	Sphingolipid signaling pathway: BAX
hsa04726__41	5.3253599905966e-09	DOWN	-5.83895022673375	1.04037849083502e-08	Serotonergic synapse: HTR3C
hsa04742__57	5.3253599905966e-09	DOWN	-5.83895022673375	1.04037849083502e-08	Taste transduction: HTR3C
hsa05205__400	5.32647210315748e-09	UP	5.83895022673375	1.04037849083502e-08	Proteoglycans in cancer: ITGA2*
hsa04152__56	5.47626971497332e-09	UP	5.83432531566307	1.06852656224661e-08	AMPK signaling pathway: FASN
hsa04530__5 15	6.11751397974664e-09	DOWN	-5.81582567138034	1.18993879585341e-08	Tight junction: IGSF5 MPDZ
hsa04621__42	6.11751397974664e-09	UP	5.81582567138034	1.18993879585341e-08	NOD-like receptor signaling pathway: MAPK8
hsa04662__36	6.11751397974664e-09	UP	5.81582567138034	1.18993879585341e-08	B cell receptor signaling pathway: CD79A
hsa04921__60	6.28890261432956e-09	UP	5.81120076030966	1.22201116983715e-08	Oxytocin signaling pathway: ELK1
hsa04971__52 53	6.4649581059408e-09	DOWN	-5.80657584923898	1.25362809918088e-08	Gastric acid secretion: EZR ACTB
hsa05223__7	6.4649581059408e-09	UP	5.80657584923898	1.25362809918088e-08	Non-small cell lung cancer: FOXO3
hsa04022__59	7.41966241914446e-09	UP	5.78345129388558	1.43579255258212e-08	cGMP-PKG signaling pathway: NPPB
hsa04360__40 139	7.41966241914446e-09	DOWN	-5.78345129388558	1.43579255258212e-08	Axon guidance: UNC5D DCC
hsa03320__62	8.28053246880217e-09	UP	5.76495164960286	1.6007325626419e-08	PPAR signaling pathway: UBC
hsa04530__6 11 45	1.00273965844478e-08	DOWN	-5.7325772721081	1.93643146784968e-08	Tight junction: CLDN24 TJP1 TJP2
hsa04530__1 5	1.03044584580562e-08	DOWN	-5.72795236103742	1.98585409668591e-08	Tight junction: IGSF5 IGSF5
hsa05215__35	1.03044584580562e-08	DOWN	-5.72795236103742	1.98585409668591e-08	Prostate cancer: CASP9
hsa04150__33	1.11810304493966e-08	UP	5.71407762782538	2.15257748098528e-08	mTOR signaling pathway: RPS6
hsa04010__107	1.1489010381649e-08	UP	5.7094527167547	2.20734667761947e-08	MAPK signaling pathway: MAP3K2
hsa04713__56	1.1489010381649e-08	DOWN	-5.7094527167547	2.20734667761947e-08	Circadian entrainment: KCNJ3
hsa04920__16	1.21298956859017e-08	UP	5.70020289461334	2.32809744574149e-08	Adipocytokine signaling pathway: POMC
hsa05200__129 130	1.3517532026974e-08	DOWN	-5.68170325033062	2.58913788773539e-08	Pathways in cancer: CTBP1 HDAC1
hsa05220__12 13	1.3517532026974e-08	DOWN	-5.68170325033062	2.58913788773539e-08	Chronic myeloid leukemia: HDAC1 CTBP1
hsa04360__18	1.42680068658768e-08	UP	5.67245342818926	2.73010029541573e-08	Axon guidance: PTK2
hsa04022__50	1.46582692592692e-08	UP	5.66782851711858	2.79339634261328e-08	cGMP-PKG signaling pathway: ATP2B1
hsa04261__14 16	1.46582692592692e-08	DOWN	-5.66782851711858	2.79339634261328e-08	Adrenergic signaling in cardiomyocytes: TNNI3 TPM1
hsa04722__38	1.46582692592692e-08	UP	5.66782851711858	2.79339634261328e-08	Neurotrophin signaling pathway: ATF4
hsa05216__14	1.46582692592692e-08	UP	5.66782851711858	2.79339634261328e-08	Thyroid cancer: MAPK1*
hsa04211__38	1.50588926367564e-08	UP	5.6632036060479	2.86683477856791e-08	Longevity regulating pathway - mammal: BAX
hsa04014__62	1.58922940454612e-08	UP	5.65395378390654	3.02243122585239e-08	Ras signaling pathway: RASSF5
hsa04950__30	1.6325624591644e-08	DOWN	-5.64932887283586	3.10170360037402e-08	Maturity onset diabetes of the young: PAX6*
hsa04920__5	1.67704214701068e-08	UP	5.64470396176518	3.18299211538694e-08	Adipocytokine signaling pathway: NFKBIA
hsa04020__7	1.72269783249975e-08	UP	5.6400790506945	3.25648815620426e-08	Calcium signaling pathway: ADCY1
hsa04723__9	1.72269783249975e-08	DOWN	-5.6400790506945	3.25648815620426e-08	Retrograde endocannabinoid signaling: PRKCA
hsa04725__20	1.72269783249975e-08	DOWN	-5.6400790506945	3.25648815620426e-08	Cholinergic synapse: PRKCA
hsa04726__18	1.72269783249975e-08	DOWN	-5.6400790506945	3.25648815620426e-08	Serotonergic synapse: PRKCA
hsa04950__8	1.76955960543852e-08	DOWN	-5.63545413962382	3.34171105388841e-08	Maturity onset diabetes of the young: NEUROD1
hsa04020__64	2.02306590466737e-08	DOWN	-5.61232958427042	3.81277917238716e-08	Calcium signaling pathway: C01330*
hsa04020__12	2.02306590466737e-08	DOWN	-5.61232958427042	3.81277917238716e-08	Calcium signaling pathway: C01330
hsa04071__89	2.077838929112e-08	UP	5.60770467319974	3.91208351483111e-08	Sphingolipid signaling pathway: C00533
hsa05166__33	2.15148507926062e-08	UP	5.01571605615267	4.04668715108179e-08	HTLV-I infection: HLA-A
hsa04917__38	2.19173709455685e-08	DOWN	-5.59845485105838	4.11005389288655e-08	Prolactin signaling pathway: IRF1
hsa05162__27 70	2.19173709455685e-08	UP	5.59845485105838	4.11005389288655e-08	Measles: STAT1 GNB2L1
hsa05200__211	2.19173709455685e-08	UP	5.59845485105838	4.11005389288655e-08	Pathways in cancer: CXCL8
hsa04022__60	2.25093622372265e-08	UP	5.5938299399877	4.21685858860904e-08	cGMP-PKG signaling pathway: TRPC6*
hsa04066__59	2.31168622217626e-08	UP	5.58920502891701	4.3263529994713e-08	HIF-1 signaling pathway: NOS2
hsa04910__12	2.37402638536281e-08	DOWN	-5.58458011784633	4.43419043548382e-08	Insulin signaling pathway: FASN
hsa04921__54	2.37402638536281e-08	UP	5.58458011784633	4.43419043548382e-08	Oxytocin signaling pathway: RCAN1
hsa04390__58	2.71102346308505e-08	UP	5.56145556249293	5.05860286706733e-08	Hippo signaling pathway: SMAD7
hsa04066__45	2.78378516313219e-08	UP	5.55683065142225	5.18921857294185e-08	HIF-1 signaling pathway: ALDOA
hsa03320__39	2.85844026200825e-08	UP	5.55220574035157	5.31257097162561e-08	PPAR signaling pathway: MMP1
hsa04024__2	2.85844026200825e-08	UP	5.55220574035157	5.31257097162561e-08	cAMP signaling pathway: CACNA1C
hsa04530__13 45 20	2.85844026200825e-08	DOWN	-5.55220574035157	5.31257097162561e-08	Tight junction: EPB41 TJP2 ACTB
hsa04024__44 67	3.17696475137596e-08	UP	5.53370609606885	5.88129730821224e-08	cAMP signaling pathway: CREB3 CREBBP
hsa04621__44	3.17696475137596e-08	UP	5.53370609606885	5.88129730821224e-08	NOD-like receptor signaling pathway: MAPK14
hsa04915__3 11	3.17696475137596e-08	UP	5.53370609606885	5.88129730821224e-08	Estrogen signaling pathway: ESR1 C00951
hsa04915__12 13	3.17696475137596e-08	UP	5.53370609606885	5.88129730821224e-08	Estrogen signaling pathway: ESR1 C00951*
hsa05216__5	3.34888191347436e-08	UP	5.52445627392749	6.19345385375818e-08	Thyroid cancer: MAPK1
hsa04919__43	3.43819103794298e-08	DOWN	-5.51983136285681	6.35237065909033e-08	Thyroid hormone signaling pathway: TBC1D4
hsa04915__12 14	3.52980847817977e-08	UP	5.51520645178613	6.50884213002923e-08	Estrogen signaling pathway: ESR1 FOS
hsa05142__18	3.52980847817977e-08	UP	5.51520645178613	6.50884213002923e-08	Chagas disease (American trypanosomiasis): FOS
hsa04151__73	3.62379188544022e-08	UP	5.51058154071545	6.6755930909237e-08	PI3K-Akt signaling pathway: MAPK1
hsa05168__122	3.81909416944866e-08	UP	5.50133171857409	7.02847986718318e-08	Herpes simplex infection: CASP3
hsa05321__123	3.92053540864649e-08	DOWN	-5.49670680750341	7.20810766423361e-08	Inflammatory bowel disease (IBD): IL5*
hsa04921__77	4.02458740578181e-08	UP	5.49208189643273	7.39217960455916e-08	Oxytocin signaling pathway: KCNJ3
hsa04740__39	4.13131507012083e-08	UP	5.48745698536205	7.5808017741768e-08	Olfactory transduction: PRKG1*
hsa04261__4	4.24078486411865e-08	DOWN	-5.48283207429137	7.75894329082663e-08	Adrenergic signaling in cardiomyocytes: SLC8A1
hsa04360__19	4.24078486411865e-08	UP	5.48283207429137	7.75894329082663e-08	Axon guidance: CDC42
hsa04962__22	4.24078486411865e-08	DOWN	-5.48283207429137	7.75894329082663e-08	Vasopressin-regulated water reabsorption: ARHGDIA
hsa04932__58	4.35306483902236e-08	UP	5.47820716322069	7.95662337794068e-08	Non-alcoholic fatty liver disease (NAFLD): BAX
hsa05200__195	4.7074709630742e-08	UP	5.46433243000865	8.59605241945231e-08	Pathways in cancer: BIRC8
hsa04014__30	4.83170523999188e-08	DOWN	-5.45970751893797	8.80579451595028e-08	Ras signaling pathway: C01245
hsa04211__23	4.83170523999188e-08	UP	5.45970751893797	8.80579451595028e-08	Longevity regulating pathway - mammal: SOD2
hsa04724__26	4.95911508734338e-08	DOWN	-5.45508260786729	9.02924152046338e-08	Glutamatergic synapse: PRKACA
hsa04670__10	5.08977888144911e-08	UP	5.45045769679661	9.25817475144518e-08	Leukocyte transendothelial migration: BCAR1
hsa04612__39	5.64660707042219e-08	UP	5.43195805251389	1.02610973745873e-07	Antigen processing and presentation: PSME3
hsa04152__38	5.94414320025863e-08	UP	5.42270823037253	1.07856113617665e-07	AMPK signaling pathway: PFKL
hsa04750__90	5.94672345438536e-08	UP	5.42270823037253	1.07856113617665e-07	Inflammatory mediator regulation of TRP channels: C01245**
hsa05160__7	6.42606811712369e-08	UP	5.40883349716049	1.16437627696002e-07	Hepatitis C: IRF3
hsa04066__43	7.1237572851024e-08	UP	5.39033385287777	1.28955105382538e-07	HIF-1 signaling pathway: PFKL
hsa04810__30	7.49957889883638e-08	UP	5.38108403073641	1.35367038913675e-07	Regulation of actin cytoskeleton: VCL*
hsa05166__26	7.49957889883638e-08	UP	5.38108403073641	1.35367038913675e-07	HTLV-I infection: NFATC1
hsa05211__31	7.49957889883638e-08	UP	5.38108403073641	1.35367038913675e-07	Renal cell carcinoma: SOS1
hsa04330__11	7.69462092858831e-08	UP	5.37645911966573	1.38621215003044e-07	Notch signaling pathway: PTCRA
hsa04931__77	7.69462092858831e-08	UP	5.37645911966573	1.38621215003044e-07	Insulin resistance: PPP2R4**
hsa04931__67	7.89457145712385e-08	UP	5.37183420859505	1.4208716252812e-07	Insulin resistance: IKBKB**
hsa04919__38	8.09954962903003e-08	UP	5.36720929752437	1.45636878018636e-07	Thyroid hormone signaling pathway: TP53
hsa04062__42	8.30967736693559e-08	UP	5.36258438645369	1.49272311400306e-07	Chemokine signaling pathway: PAK1
hsa04360__31	8.74588349417635e-08	UP	5.35333456431233	1.56509667481499e-07	Axon guidance: CDC42*
hsa04620__34	8.74588349417635e-08	UP	5.35333456431233	1.56509667481499e-07	Toll-like receptor signaling pathway: IL1B
hsa04922__51	8.74588349417635e-08	DOWN	-5.35333456431233	1.56509667481499e-07	Glucagon signaling pathway: G6PC
hsa04971__55	8.74588349417635e-08	UP	5.35333456431233	1.56509667481499e-07	Gastric acid secretion: MYLK4
hsa04932__138	9.44202921166534e-08	UP	5.33945983110028	1.68806592661457e-07	Non-alcoholic fatty liver disease (NAFLD): CEBPA
hsa04151__25	9.68577825763711e-08	UP	5.3348349200296	1.72835492365623e-07	PI3K-Akt signaling pathway: CDKN1B
hsa04660__43	9.68577825763711e-08	UP	5.3348349200296	1.72835492365623e-07	T cell receptor signaling pathway: RHOA
hsa04971__56	1.0454131799239e-07	UP	5.32096018681756	1.86192546452796e-07	Gastric acid secretion: CAMK2A
hsa04972__39	1.0454131799239e-07	UP	5.32096018681756	1.86192546452796e-07	Pancreatic secretion: KCNMA1*
hsa05161__188	1.07231180995802e-07	DOWN	-5.31633527574688	1.90802451790826e-07	Hepatitis B: IFNB1
hsa04390__80	1.09987971392753e-07	UP	5.3117103646762	1.95522609505187e-07	Hippo signaling pathway: BIRC2
hsa04022__44	1.12813293992785e-07	UP	5.30708545360552	2.00166363939985e-07	cGMP-PKG signaling pathway: BAD
hsa05166__74	1.12813293992785e-07	UP	5.30708545360552	2.00166363939985e-07	HTLV-I infection: NFKB1
hsa04015__63	1.18676140483405e-07	UP	5.29783563146416	2.10370252800301e-07	Rap1 signaling pathway: GNAI1
hsa04010__58	1.24833312187715e-07	UP	5.2885858093228	2.21076148539789e-07	MAPK signaling pathway: CDC25B
hsa05161__66 67	1.2802668911034e-07	DOWN	-5.28396089825212	2.26304937759481e-07	Hepatitis B: NFKB1 NFKBIA
hsa05200__213	1.2802668911034e-07	UP	5.28396089825212	2.26304937759481e-07	Pathways in cancer: CSF2RA
hsa04014__24	1.31299031527959e-07	UP	5.27933598718144	2.31871128046086e-07	Ras signaling pathway: PLD1
hsa04540__1	1.48907513069306e-07	DOWN	-5.25621143182804	2.62482872293686e-07	Gap junction: C00681
hsa04932__96	1.48912582152778e-07	UP	5.25621143182804	2.62482872293686e-07	Non-alcoholic fatty liver disease (NAFLD): IL6*
hsa04970__27	1.52699754067691e-07	UP	5.25158652075736	2.68906127360066e-07	Salivary secretion: PRKCA
hsa03320__60	1.60555503265942e-07	UP	5.242336698616	2.82211216685411e-07	PPAR signaling pathway: CYP27A1
hsa04350__10	1.60555503265942e-07	DOWN	-5.242336698616	2.82211216685411e-07	TGF-beta signaling pathway: SMAD4
hsa03460__16 49	1.64628534601239e-07	UP	5.23771178754532	2.89100015435261e-07	Fanconi anemia pathway: FANCM C19orf40
hsa05133__24	1.73076426926103e-07	UP	5.22846196540396	3.03651359658401e-07	Pertussis: NFKB1
hsa04722__85	1.8194272707827e-07	UP	5.2192121432626	3.18611728033615e-07	Neurotrophin signaling pathway: BAX
hsa05161__26	1.8194272707827e-07	UP	5.2192121432626	3.18611728033615e-07	Hepatitis B: MMP9
hsa04933__25	1.91247361865549e-07	UP	5.20996232112124	3.34593848180044e-07	AGE-RAGE signaling pathway in diabetic complications: IL1A
hsa05321__74	1.96070529169229e-07	DOWN	-5.20533741005056	3.4271304586882e-07	Inflammatory bowel disease (IBD): IL5
hsa04022__19	2.06072026282967e-07	DOWN	-5.1960875879092	3.59859978982988e-07	cGMP-PKG signaling pathway: CNGB1
hsa04064__95	2.11255923409172e-07	UP	5.19146267683852	3.68228089133427e-07	NF-kappa B signaling pathway: BCL2L1**
hsa04919__101	2.11255923409172e-07	UP	5.19146267683852	3.68228089133427e-07	Thyroid hormone signaling pathway: NOTCH1
hsa04350__21	2.16565735410066e-07	UP	5.18683776576784	3.77133472507428e-07	TGF-beta signaling pathway: CDKN2B
hsa04540__11	2.22004404376611e-07	DOWN	-5.18221285469716	3.86246551688567e-07	Gap junction: C00780
hsa05220__50	2.3328041206438e-07	UP	5.1729630325558	4.05489263893588e-07	Chronic myeloid leukemia: MAPK1
hsa04919__21 53	2.45108824989928e-07	DOWN	-5.16371321041444	4.25655713637778e-07	Thyroid hormone signaling pathway: THRA C02465
hsa04810__8 79	2.70528038436872e-07	DOWN	-5.14521356613172	4.68931904264652e-07	Regulation of actin cytoskeleton: ARPC5 ACTB
hsa04810__8 82	2.70528038436872e-07	DOWN	-5.14521356613172	4.68931904264652e-07	Regulation of actin cytoskeleton: ARPC5 ACTB*
hsa04950__11	3.29220598190278e-07	DOWN	-5.10821427756627	5.70143321658556e-07	Maturity onset diabetes of the young: HNF4G
hsa04664__47	3.54255474193854e-07	UP	5.09433954435423	6.12933734816069e-07	Fc epsilon RI signaling pathway: MAPK8
hsa05223__21	3.71955777404189e-07	UP	5.08508972221287	6.42966794611288e-07	Non-small cell lung cancer: FOXO3*
hsa04010__63	3.81123025220133e-07	UP	5.08046481114219	6.5760345673887e-07	MAPK signaling pathway: MAX
hsa04022__43	3.81123025220133e-07	UP	5.08046481114219	6.5760345673887e-07	cGMP-PKG signaling pathway: MAPK1
hsa04022__51	4.00116041763203e-07	UP	5.07121498900083	6.89741323369778e-07	cGMP-PKG signaling pathway: GTF2I
hsa05162__27 28	4.30328079972955e-07	UP	5.05734025578879	7.40463793286798e-07	Measles: STAT1 IRF9
hsa05200__227	4.30328079972955e-07	DOWN	-5.05734025578879	7.40463793286798e-07	Pathways in cancer: FOXO1
hsa05120__52	4.40879200155691e-07	DOWN	-5.05271534471811	7.57924992765364e-07	Epithelial cell signaling in Helicobacter pylori infection: LYN
hsa04151__109	5.09624579665857e-07	UP	5.02496587829403	8.73708563131519e-07	PI3K-Akt signaling pathway: RXRA
hsa04152__63	5.09624579665857e-07	UP	5.02496587829403	8.73708563131519e-07	AMPK signaling pathway: PPARG
hsa04213__52	5.09624579665857e-07	UP	5.02496587829403	8.73708563131519e-07	Longevity regulating pathway - multiple species: SOD2
hsa04740__21	5.22044308035777e-07	DOWN	-5.02034096722335	8.94185282405857e-07	Olfactory transduction: PDE1A
hsa04530__5 10	5.34755642845715e-07	DOWN	-5.01571605615267	9.1345986627918e-07	Tight junction: IGSF5 MAGI1
hsa04724__67	5.34755642845715e-07	DOWN	-5.01571605615267	9.1345986627918e-07	Glutamatergic synapse: PLD1
hsa05200__198	5.34755642845715e-07	UP	5.01571605615267	9.1345986627918e-07	Pathways in cancer: BCL2L1*
hsa05215__12	5.47765152535365e-07	UP	5.01109114508199	9.34832626352361e-07	Prostate cancer: KLK3
hsa05161__57	5.8865055018003e-07	DOWN	-4.99721641186995	1.00369726296577e-06	Hepatitis B: STAT3*
hsa04151__105 62	6.17525264210064e-07	DOWN	-4.98796658972859	1.05197640204054e-06	PI3K-Akt signaling pathway: CCND1 CDK2
hsa04919__46	6.32469870425683e-07	DOWN	-4.98334167865791	1.07451255563278e-06	Thyroid hormone signaling pathway: ATP1B4
hsa05205__150	6.32469870425683e-07	DOWN	-4.98334167865791	1.07451255563278e-06	Proteoglycans in cancer: PRKCA
hsa05219__19	6.32469870425683e-07	DOWN	-4.98334167865791	1.07451255563278e-06	Bladder cancer: TP53
hsa03320__59	6.47762748315434e-07	UP	4.97871676758723	1.09850740440857e-06	PPAR signaling pathway: NR1H3
hsa04622__45	6.47762748315434e-07	UP	4.97871676758723	1.09850740440857e-06	RIG-I-like receptor signaling pathway: MAPK14
hsa05160__22 23	6.63411679331799e-07	UP	4.97409185651655	1.1240311501032e-06	Hepatitis C: STAT1 IRF9
hsa04024__93	6.79424610688311e-07	UP	4.96946694544587	1.15012508421922e-06	cAMP signaling pathway: ORAI1
hsa04211__56	7.12575112193791e-07	DOWN	-4.96021712330451	1.20515628785971e-06	Longevity regulating pathway - mammal: CAT
hsa05321__122	7.2972943596593e-07	DOWN	-4.95559221223383	1.23305900196042e-06	Inflammatory bowel disease (IBD): IL4**
hsa04022__49	7.47281274327608e-07	UP	4.95096730116315	1.26158267247221e-06	cGMP-PKG signaling pathway: ATP1B4
hsa05132__55	7.65239454699847e-07	UP	4.94634239009247	1.29074051650001e-06	Salmonella infection: IL18
hsa04630__1	7.83612991282832e-07	UP	4.94171747902179	1.32054601849367e-06	Jak-STAT signaling pathway: MYC
hsa04728__54	8.21643146269358e-07	UP	4.93246765688043	1.38339379197144e-06	Dopaminergic synapse: CAMK2A
hsa04510__19 23	8.41318760952684e-07	DOWN	-4.92784274580975	1.41398743455286e-06	Focal adhesion: VCL TLN1
hsa04520__64	8.41318760952684e-07	UP	4.92784274580975	1.41398743455286e-06	Adherens junction: CTNND1**
hsa05134__72	8.61447732234786e-07	UP	4.92321783473907	1.44652394000819e-06	Legionellosis: IL12A
hsa04710__7	9.2465589689582e-07	UP	4.90934310152703	1.54989155242395e-06	Circadian rhythm: PER1
hsa05217__19	9.2465589689582e-07	DOWN	-4.90934310152703	1.54989155242395e-06	Basal cell carcinoma: HHIP
hsa04720__32	9.467004739451e-07	UP	4.90471819045635	1.58542797731091e-06	Long-term potentiation: ITPR1
hsa03460__25 40	9.69250580314384e-07	UP	4.90009327938567	1.62174696385639e-06	Fanconi anemia pathway: MLH1 PMS2
hsa04066__47	9.92317315475343e-07	UP	4.89546836831499	1.65739043180282e-06	HIF-1 signaling pathway: PGK1
hsa05030__76	9.92317315475343e-07	UP	4.89546836831499	1.65739043180282e-06	Cocaine addiction: PDYN
hsa04510__19 26	1.01591201083736e-06	DOWN	-4.8908434572443	1.69529189019841e-06	Focal adhesion: VCL ACTN4
hsa04530__4 45	1.0400462343233e-06	DOWN	-4.88621854617362	1.73402562049112e-06	Tight junction: OCLN TJP2
hsa05164__34	1.06473179502955e-06	UP	4.88159363510294	1.77360908055011e-06	Influenza A: IL1B
hsa04931__124	1.11580539891763e-06	DOWN	-4.87234381296158	1.85704016347762e-06	Insulin resistance: FOXO1*
hsa04910__26	1.14221830930853e-06	DOWN	-4.8677189018909	1.89931699397409e-06	Insulin signaling pathway: RPS6
hsa03320__29	1.2540130059477e-06	UP	4.84921925760818	2.08152865563227e-06	PPAR signaling pathway: OLR1
hsa05164__99	1.2540130059477e-06	DOWN	-4.84921925760818	2.08152865563227e-06	Influenza A: FDPS
hsa04724__33 70 69	1.28356493973989e-06	DOWN	-4.8445943465375	2.12870125487313e-06	Glutamatergic synapse: ITPR1 HOMER3 HOMER3
hsa04742__18	1.3137861579155e-06	DOWN	-4.83996943546682	2.17689963908574e-06	Taste transduction: PDE1A
hsa04210__69	1.37629473270749e-06	UP	4.83071961332546	2.27645933341317e-06	Apoptosis: PTPN13
hsa05016__52	1.37629473270749e-06	UP	4.83071961332546	2.27645933341317e-06	Huntington's disease: CASP3
hsa04261__52	1.40861198380343e-06	DOWN	-4.82609470225478	2.32581890823079e-06	Adrenergic signaling in cardiomyocytes: MAPK14
hsa05218__8	1.40861198380343e-06	UP	4.82609470225478	2.32581890823079e-06	Melanoma: CDK4
hsa05205__324	1.4754494666108e-06	UP	4.81684488011342	2.43403823332897e-06	Proteoglycans in cancer: KDR*
hsa04360__6	1.5100014716142e-06	UP	4.81221996904274	2.48885330277464e-06	Axon guidance: MAPK1
hsa04724__52	1.5453307111071e-06	UP	4.80759505797206	2.54485224028943e-06	Glutamatergic synapse: CACNA1A
hsa04550__34	1.58145389601531e-06	UP	4.80297014690138	2.59978291392194e-06	Signaling pathways regulating pluripotency of stem cells: MAPK1*
hsa05200__201	1.58145389601531e-06	UP	4.80297014690138	2.59978291392194e-06	Pathways in cancer: PDGFB
hsa04916__4	1.65615065831179e-06	UP	4.79372032476002	2.72019850259427e-06	Melanogenesis: TYR
hsa04020__16	1.69475938987171e-06	DOWN	-4.78909541368934	2.77875470643015e-06	Calcium signaling pathway: C06124
hsa04530__4 53	1.69475938987171e-06	DOWN	-4.78909541368934	2.77875470643015e-06	Tight junction: OCLN OCLN
hsa04071__11	1.77458813832542e-06	UP	4.77984559154798	2.90710646199953e-06	Sphingolipid signaling pathway: PRKCA
hsa04015__96	1.90114239982851e-06	DOWN	-4.76597085833594	3.11171303944056e-06	Rap1 signaling pathway: PLCE1
hsa04750__51	1.94516690662348e-06	DOWN	-4.76134594726526	3.1755615887443e-06	Inflammatory mediator regulation of TRP channels: TRPV4
hsa04750__61	1.94516690662348e-06	DOWN	-4.76134594726526	3.1755615887443e-06	Inflammatory mediator regulation of TRP channels: TRPV4*
hsa05032__4	1.94522160119462e-06	UP	4.76134594726526	3.1755615887443e-06	Morphine addiction: ADCY1
hsa04014__41	1.99028174445397e-06	UP	4.75672103619458	3.24348603454381e-06	Ras signaling pathway: RAC1*
hsa04022__63	1.99028174445397e-06	UP	4.75672103619458	3.24348603454381e-06	cGMP-PKG signaling pathway: C00575
hsa05221__29	2.08342865550805e-06	DOWN	-4.74747121405322	3.39234180563227e-06	Acute myeloid leukemia: RPS6KB1
hsa04914__30	2.18063349186433e-06	UP	4.73822139191186	3.54467007479414e-06	Progesterone-mediated oocyte maturation: CDK1*
hsa05231__21	2.18075497949017e-06	UP	4.73822139191186	3.54467007479414e-06	Choline metabolism in cancer: PCYT1A
hsa04919__99	2.44354716385546e-06	DOWN	-4.71509683655846	3.96496124428705e-06	Thyroid hormone signaling pathway: WNT4
hsa04921__34 35	2.44354716385546e-06	UP	4.71509683655846	3.96496124428705e-06	Oxytocin signaling pathway: MYL9 ACTB
hsa05014__32 34	2.67541168189583e-06	UP	4.69659719227574	4.33744482336692e-06	Amyotrophic lateral sclerosis (ALS): NEFM PRPH
hsa05200__185	2.73659613563272e-06	DOWN	-4.69197228120506	4.43281391280507e-06	Pathways in cancer: HHIP
hsa04024__113	2.79912212838525e-06	DOWN	-4.68734737013438	4.53018990459593e-06	cAMP signaling pathway: PTCH1
hsa04722__73 77	3.20406053650995e-06	DOWN	-4.6595979037103	5.18109272642185e-06	Neurotrophin signaling pathway: NGFRAP1 YWHAE
hsa04620__12	3.42704128375127e-06	UP	4.64572317049825	5.5368964507039e-06	Toll-like receptor signaling pathway: NFKB1
hsa04010__79	3.50462038888119e-06	UP	4.64109825942757	5.65251648987791e-06	MAPK signaling pathway: HSPB1
hsa05161__45	3.50462038888119e-06	UP	4.64109825942757	5.65251648987791e-06	Hepatitis B: PCNA
hsa05166__136 139	3.66486042733424e-06	UP	4.63184843728621	5.90589429070415e-06	HTLV-I infection: TP53 TBPL2
hsa04728__36	3.83200953145644e-06	DOWN	-4.62259861514485	6.16484346074717e-06	Dopaminergic synapse: TH
hsa04024__111	3.83211131567466e-06	UP	4.62259861514485	6.16484346074717e-06	cAMP signaling pathway: JUN
hsa04360__58	3.91845657456772e-06	UP	4.61797370407417	6.2983574881204e-06	Axon guidance: PLXNC1
hsa05133__96	4.00666485862418e-06	UP	4.61334879300349	6.43463527295285e-06	Pertussis: IL1B
hsa05205__120	4.18882432510154e-06	DOWN	-4.60409897086213	6.72143544565824e-06	Proteoglycans in cancer: PLAU
hsa04916__8	4.47701738639754e-06	DOWN	-4.59022423765009	7.17774374491551e-06	Melanogenesis: TYR*
hsa05205__220	4.57723396255017e-06	UP	4.58559932657941	7.3321590926102e-06	Proteoglycans in cancer: FAS
hsa04068__72	4.67959752993494e-06	UP	4.58097441550873	7.48337341170021e-06	FoxO signaling pathway: SMAD2
hsa05220__22	4.67959752993494e-06	UP	4.58097441550873	7.48337341170021e-06	Chronic myeloid leukemia: CDKN1B
hsa04062__59	4.89094151893304e-06	UP	4.57172459336737	7.80805362283363e-06	Chemokine signaling pathway: FOXO3
hsa05212__27	4.89094151893304e-06	UP	4.57172459336737	7.80805362283363e-06	Pancreatic cancer: BCL2L1*
hsa04914__34	5.34137607227212e-06	DOWN	-4.55322494908465	8.51267653926998e-06	Progesterone-mediated oocyte maturation: MAPK14
hsa05132__13	5.34137607227212e-06	UP	4.55322494908465	8.51267653926998e-06	Salmonella infection: FOS
hsa04068__57	5.46004206269515e-06	UP	4.54860003801397	8.69442291169846e-06	FoxO signaling pathway: IL7R
hsa04550__69	5.83137375031589e-06	UP	4.53472530480193	9.27785882882605e-06	Signaling pathways regulating pluripotency of stem cells: ID1
hsa05020__48	6.22680649059182e-06	DOWN	-4.52085057158989	9.89025308184448e-06	Prion diseases: SOD1
hsa05205__146	6.22680649059182e-06	UP	4.52085057158989	9.89025308184448e-06	Proteoglycans in cancer: PTK2
hsa04921__11	6.50454675855904e-06	UP	4.51160074944853	1.03139606407869e-05	Oxytocin signaling pathway: PRKACA
hsa05200__214	6.50454675855904e-06	UP	4.51160074944853	1.03139606407869e-05	Pathways in cancer: CSF3R
hsa05010__59	6.79411651022988e-06	UP	4.50235092730717	1.07640345048246e-05	Alzheimer's disease: LRP1
hsa04917__48	6.94348611863328e-06	DOWN	-4.49772601623649	1.09914156840033e-05	Prolactin signaling pathway: CCND2
hsa04015__67	7.09599375640599e-06	UP	4.49310110516581	1.12139379884667e-05	Rap1 signaling pathway: AKT3
hsa04922__37	7.09599375640599e-06	DOWN	-4.49310110516581	1.12139379884667e-05	Glucagon signaling pathway: PYGB
hsa05133__73	7.41067467394806e-06	UP	4.48385128302445	1.17013930355869e-05	Pertussis: FOS
hsa04066__50	7.57297668941783e-06	UP	4.47922637195377	1.19476265318355e-05	HIF-1 signaling pathway: TF
hsa04724__51	7.73867424702009e-06	UP	4.47460146088309	1.21783659213993e-05	Glutamatergic synapse: ADRBK1
hsa04932__97	7.73867424702009e-06	UP	4.47460146088309	1.21783659213993e-05	Non-alcoholic fatty liver disease (NAFLD): TNF*
hsa04971__37	7.73867424702009e-06	UP	4.47460146088309	1.21783659213993e-05	Gastric acid secretion: KCNQ1
hsa04014__43	8.25682069368047e-06	UP	4.46072672767105	1.29720452202555e-05	Ras signaling pathway: ELK1
hsa04211__43 59 60 61	8.25682069368047e-06	DOWN	-4.46072672767105	1.29720452202555e-05	Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101
hsa04810__23	8.62049941411215e-06	UP	4.45147690552969	1.35320955715261e-05	Regulation of actin cytoskeleton: GSN
hsa05010__50	9.39430184339426e-06	UP	4.43297726124697	1.47221794526587e-05	Alzheimer's disease: ERN1
hsa05205__270	9.39430184339426e-06	UP	4.43297726124697	1.47221794526587e-05	Proteoglycans in cancer: MAPK1****
hsa04360__11	9.597878101153e-06	DOWN	-4.42835235017629	1.49911994614019e-05	Axon guidance: NFATC2
hsa04662__6	9.597878101153e-06	UP	4.42835235017629	1.49911994614019e-05	B cell receptor signaling pathway: NFKB1
hsa04668__40	9.597878101153e-06	UP	4.42835235017629	1.49911994614019e-05	TNF signaling pathway: JUN
hsa04917__68	9.597878101153e-06	DOWN	-4.42835235017629	1.49911994614019e-05	Prolactin signaling pathway: CCND1
hsa04115__25	9.80566450969981e-06	UP	4.42372743910561	1.5290326650395e-05	p53 signaling pathway: CD82
hsa05200__52	9.80566450969981e-06	UP	4.42372743910561	1.5290326650395e-05	Pathways in cancer: CDKN1B
hsa04611__43	1.02341994329164e-05	UP	4.41447761696425	1.59453239920811e-05	Platelet activation: MYL12B
hsa04010__88 92	1.04551175992336e-05	UP	4.40985270589356	1.62222675218497e-05	MAPK signaling pathway: ECSIT TRAF6
hsa04727__17 37	1.04551175992336e-05	DOWN	-4.40985270589356	1.62222675218497e-05	GABAergic synapse: GABRA1 GPHN
hsa04915__30	1.04551175992336e-05	DOWN	-4.40985270589356	1.62222675218497e-05	Estrogen signaling pathway: CREB3*
hsa05160__12 13 14	1.04551175992336e-05	DOWN	-4.40985270589356	1.62222675218497e-05	Hepatitis C: IKBKG CHUK IKBKB
hsa05166__89 90	1.04551175992336e-05	UP	4.40985270589356	1.62222675218497e-05	HTLV-I infection: CHUK IKBKG
hsa05205__142	1.16297509542433e-05	DOWN	-4.38672815054016	1.80299521807121e-05	Proteoglycans in cancer: CTNNB1
hsa03320__36	1.18793306211602e-05	DOWN	-4.38210323946948	1.8401700113075e-05	PPAR signaling pathway: SLC27A4
hsa04380__20	1.26591095733929e-05	UP	4.36822850625744	1.95773390028027e-05	Osteoclast differentiation: MAP2K1
hsa04726__39	1.26591095733929e-05	DOWN	-4.36822850625744	1.95773390028027e-05	Serotonergic synapse: CACNA1C
hsa04068__43	1.29297183797515e-05	UP	4.36360359518676	1.99629752140945e-05	FoxO signaling pathway: CDKN1A
hsa04610__46	1.29297183797515e-05	UP	4.36360359518676	1.99629752140945e-05	Complement and coagulation cascades: C2
hsa05020__52	1.32058409346785e-05	UP	4.35897868411608	2.0355845050255e-05	Prion diseases: FYN
hsa05132__8	1.32058409346785e-05	DOWN	-4.35897868411608	2.0355845050255e-05	Salmonella infection: TJP1
hsa05132__54	1.34875835562463e-05	UP	4.3543537730454	2.07560765783675e-05	Salmonella infection: IL1B
hsa05200__48	1.34875835562463e-05	DOWN	-4.3543537730454	2.07560765783675e-05	Pathways in cancer: MTOR
hsa04014__38	1.37750544836067e-05	UP	4.34972886197472	2.11811189645638e-05	Ras signaling pathway: MAPK8
hsa04915__58	1.46729489848763e-05	DOWN	-4.33585412876268	2.25065070551695e-05	Estrogen signaling pathway: CREB3***
hsa04925__33	1.46729489848763e-05	DOWN	-4.33585412876268	2.25065070551695e-05	Aldosterone synthesis and secretion: CYP11B2
hsa04972__18	1.46729489848763e-05	UP	4.33585412876268	2.25065070551695e-05	Pancreatic secretion: PRKCA
hsa04014__104	1.49844550809281e-05	UP	4.331229217692	2.29655718573115e-05	Ras signaling pathway: BRAP*
hsa04621__30 32	1.59572540914096e-05	UP	4.31735448447996	2.4416677880911e-05	NOD-like receptor signaling pathway: PYCARD CASP1
hsa04910__17	1.59572540914096e-05	UP	4.31735448447996	2.4416677880911e-05	Insulin signaling pathway: C00031
hsa04924__49	1.69900724248571e-05	DOWN	-4.30347975126792	2.59336686322555e-05	Renin secretion: PDE1A
hsa05016__60	1.69900724248571e-05	DOWN	-4.30347975126792	2.59336686322555e-05	Huntington's disease: CASP3*
hsa05134__35	1.69900724248571e-05	DOWN	-4.30347975126792	2.59336686322555e-05	Legionellosis: CASP3
hsa04725__64	1.80864020575073e-05	UP	4.28960501805588	2.75846992419287e-05	Cholinergic synapse: KCNJ3
hsa04064__94	1.84665895614079e-05	UP	4.2849801069852	2.81188993402638e-05	NF-kappa B signaling pathway: BCL2L1*
hsa04666__41	1.84665895614079e-05	UP	4.2849801069852	2.81188993402638e-05	Fc gamma R-mediated phagocytosis: MARCKS
hsa05134__73	1.88543824807332e-05	UP	4.28035519591452	2.86397612621646e-05	Legionellosis: CXCL1
hsa05161__30	1.88543824807332e-05	UP	4.28035519591452	2.86397612621646e-05	Hepatitis B: MYC
hsa05200__215	1.88543824807332e-05	UP	4.28035519591452	2.86397612621646e-05	Pathways in cancer: CSF1R
hsa04068__51	1.92499244964648e-05	UP	4.27573028484384	2.91933883203046e-05	FoxO signaling pathway: BCL6
hsa04068__56	1.92499244964648e-05	UP	4.27573028484384	2.91933883203046e-05	FoxO signaling pathway: BCL6*
hsa04914__39	2.00648432637674e-05	DOWN	-4.26648046270248	3.03802099054142e-05	Progesterone-mediated oocyte maturation: PIK3R5
hsa05133__60	2.00648432637674e-05	DOWN	-4.26648046270248	3.03802099054142e-05	Pertussis: C5
hsa04660__26	2.0484520224128e-05	UP	4.2618555516318	3.09408468658653e-05	T cell receptor signaling pathway: GRB2
hsa04664__25	2.0484520224128e-05	UP	4.2618555516318	3.09408468658653e-05	Fc epsilon RI signaling pathway: MAPK14
hsa05217__3	2.0484520224128e-05	UP	4.2618555516318	3.09408468658653e-05	Basal cell carcinoma: GLI1
hsa04931__35	2.09125467826353e-05	DOWN	-4.25723064056112	3.15113676059115e-05	Insulin resistance: C00369
hsa05200__173	2.09125467826353e-05	DOWN	-4.25723064056112	3.15113676059115e-05	Pathways in cancer: CCNA1
hsa05221__16	2.09125467826353e-05	DOWN	-4.25723064056112	3.15113676059115e-05	Acute myeloid leukemia: CCNA1
hsa04010__87	2.13490797195953e-05	UP	4.25260572949044	3.21433660201278e-05	MAPK signaling pathway: STK3
hsa04920__6	2.22483056356456e-05	UP	4.24335590734908	3.34704293750024e-05	Adipocytokine signaling pathway: PTPN11
hsa04115__43 57	2.27113260942807e-05	UP	4.2387309962784	3.41396653849227e-05	p53 signaling pathway: CDK1 CCNB3
hsa04919__89	2.31835079808758e-05	DOWN	-4.23410608520772	3.48215919233138e-05	Thyroid hormone signaling pathway: CASP9
hsa03460__16 34	2.36650222659382e-05	UP	4.22948117413704	3.5431535328843e-05	Fanconi anemia pathway: FANCM STRA13
hsa04110__43 83 84 85	2.36650222659382e-05	UP	4.22948117413704	3.5431535328843e-05	Cell cycle: SMC1B SMC3 STAG1 RAD21
hsa04622__11	2.36650222659382e-05	UP	4.22948117413704	3.5431535328843e-05	RIG-I-like receptor signaling pathway: IRF7
hsa05321__19	2.36650222659382e-05	UP	4.22948117413704	3.5431535328843e-05	Inflammatory bowel disease (IBD): TNF
hsa04210__114	2.56879279619701e-05	UP	4.21098152985432	3.8429631083234e-05	Apoptosis: HRK
hsa05212__31	2.62187746326554e-05	UP	4.20635661878364	3.91925835598722e-05	Pancreatic cancer: RAC1*
hsa04923__38	2.73119280081904e-05	DOWN	-4.19710679664228	4.07618051845829e-05	Regulation of lipolysis in adipocytes: PDE3B
hsa05012__71	2.73119280081904e-05	UP	4.19710679664228	4.07618051845829e-05	Parkinson's disease: PRKACA*
hsa04020__8	2.90332506772317e-05	DOWN	-4.18323206343024	4.32964111289828e-05	Calcium signaling pathway: PDE1A
hsa04310__16	2.96295913794286e-05	UP	4.17860715235956	4.41506758143905e-05	Wnt signaling pathway: CAMK2A
hsa05032__13	3.02375623340787e-05	UP	4.17398224128888	4.49852570275011e-05	Morphine addiction: PRKACA
hsa05205__69	3.02375623340787e-05	UP	4.17398224128888	4.49852570275011e-05	Proteoglycans in cancer: MAPK1*
hsa05134__70	3.21334106483782e-05	UP	4.16010750807683	4.77301807180258e-05	Legionellosis: IL6
hsa05162__23	3.21334106483782e-05	UP	4.16010750807683	4.77301807180258e-05	Measles: IRF3
hsa05321__55	3.34594745253781e-05	UP	4.15085768593547	4.96606260925635e-05	Inflammatory bowel disease (IBD): IL4*
hsa05032__31	3.5546427446828e-05	DOWN	-4.13698295272343	5.25919190335354e-05	Morphine addiction: GABRR3
hsa05032__33	3.5546427446828e-05	DOWN	-4.13698295272343	5.25919190335354e-05	Morphine addiction: GABRR3*
hsa05032__55	3.5546427446828e-05	DOWN	-4.13698295272343	5.25919190335354e-05	Morphine addiction: GABRR3**
hsa05205__145	3.5546427446828e-05	UP	4.13698295272343	5.25919190335354e-05	Proteoglycans in cancer: PXN
hsa04360__35	3.62691310498796e-05	UP	4.13235804165275	5.35768060084307e-05	Axon guidance: ROCK1*
hsa04666__50 52	3.62691310498796e-05	UP	4.13235804165275	5.35768060084307e-05	Fc gamma R-mediated phagocytosis: DNM2 AMPH
hsa04923__66	3.70057717402826e-05	UP	4.12773313058207	5.45791562794277e-05	Regulation of lipolysis in adipocytes: LIPE
hsa05215__9	3.70057717402826e-05	UP	4.12773313058207	5.45791562794277e-05	Prostate cancer: CDKN1B
hsa04650__16	4.17327481027429e-05	UP	4.09998366415799	6.14544151136786e-05	Natural killer cell mediated cytotoxicity: PRKCA
hsa04912__43	4.17327481027429e-05	UP	4.09998366415799	6.14544151136786e-05	GnRH signaling pathway: PTK2B
hsa04211__51	4.25742672326453e-05	UP	4.09535875308731	6.25465583503835e-05	Longevity regulating pathway - mammal: NFKB1
hsa04270__24	4.25742672326453e-05	UP	4.09535875308731	6.25465583503835e-05	Vascular smooth muscle contraction: ACTA2
hsa05132__41	4.25742672326453e-05	UP	4.09535875308731	6.25465583503835e-05	Salmonella infection: ACTB*
hsa04014__63	4.43058390418538e-05	UP	4.08610893094595	6.49381213413754e-05	Ras signaling pathway: TIAM1*
hsa04910__48	4.43058390418538e-05	DOWN	-4.08610893094595	6.49381213413754e-05	Insulin signaling pathway: PPARGC1A
hsa05032__37	4.43058390418538e-05	UP	4.08610893094595	6.49381213413754e-05	Morphine addiction: KCNJ3
hsa04152__57	4.79713681145375e-05	UP	4.06760928666323	7.02558072386718e-05	AMPK signaling pathway: ACACA*
hsa05016__55	4.89316906007273e-05	UP	4.06298437559255	7.15506977733591e-05	Huntington's disease: TGM2
hsa05205__188	4.89316906007273e-05	UP	4.06298437559255	7.15506977733591e-05	Proteoglycans in cancer: TNF
hsa05215__43	5.19210511719341e-05	UP	4.04910964238051	7.5748196265147e-05	Prostate cancer: C05981
hsa04213__60	5.19231914792492e-05	DOWN	-4.04910964238051	7.5748196265147e-05	Longevity regulating pathway - multiple species: CAT
hsa04933__21	5.19231914792492e-05	UP	4.04910964238051	7.5748196265147e-05	AGE-RAGE signaling pathway in diabetic complications: SMAD4
hsa04152__44	6.07707398759364e-05	UP	4.01211035381507	8.85180001758795e-05	AMPK signaling pathway: SLC2A4
hsa04728__61	6.07707398759364e-05	UP	4.01211035381507	8.85180001758795e-05	Dopaminergic synapse: KCNJ3
hsa05205__451	6.3195946053141e-05	UP	4.00286053167371	9.19792274468256e-05	Proteoglycans in cancer: KDR**
hsa04310__35	6.44426339924447e-05	DOWN	-3.99823562060303	9.37211372072783e-05	Wnt signaling pathway: JUN
hsa04310__32	6.57125758812376e-05	DOWN	-3.99361070953235	9.5494145460824e-05	Wnt signaling pathway: PPARD
hsa04976__95 96	6.7006177795592e-05	UP	3.98898579846167	9.72987697665513e-05	Bile secretion: SLC51A SLC51B
hsa04213__55	6.83238523555178e-05	DOWN	-3.98436088739099	9.89826665967756e-05	Longevity regulating pathway - multiple species: CRYAB
hsa05142__49	6.83238523555178e-05	DOWN	-3.98436088739099	9.89826665967756e-05	Chagas disease (American trypanosomiasis): ADCY1
hsa05164__78	6.83238523555178e-05	DOWN	-3.98436088739099	9.89826665967756e-05	Influenza A: GSK3B
hsa04012__31	7.67593807526539e-05	UP	3.95661142096691	0.000111032237439751	ErbB signaling pathway: BAD
hsa04520__10	7.67593807526539e-05	DOWN	-3.95661142096691	0.000111032237439751	Adherens junction: NLK
hsa05100__15	8.2920242851322e-05	DOWN	-3.93811177668419	0.000119851643321257	Bacterial invasion of epithelial cells: CTNNA1
hsa04540__14 16	8.45319186500874e-05	UP	3.93348686561351	0.000121993452491178	Gap junction: GJA1 GJA1
hsa04540__14 15	8.45319186500874e-05	UP	3.93348686561351	0.000121993452491178	Gap junction: GJA1 GJA1*
hsa04976__34	8.95464033749228e-05	DOWN	-3.91961213240146	0.000129031972347761	Bile secretion: SLCO1B1
hsa05034__99	8.95464033749228e-05	UP	3.91961213240146	0.000129031972347761	Alcoholism: PDYN
hsa04950__16	9.12794334526398e-05	DOWN	-3.91498722133078	0.000131428394986598	Maturity onset diabetes of the young: PAX4
hsa04921__28	0.000100430188889469	DOWN	-3.89186266597738	0.000144382804072924	Oxytocin signaling pathway: EEF2
hsa05200__76	0.000100430188889469	UP	3.89186266597738	0.000144382804072924	Pathways in cancer: RAC1
hsa04022__23	0.000106329319595489	DOWN	-3.87798793276534	0.000152513581312919	cGMP-PKG signaling pathway: CACNA1C
hsa04151__37	0.000106329319595489	DOWN	-3.87798793276534	0.000152513581312919	PI3K-Akt signaling pathway: G6PC
hsa04916__15	0.000106329319595489	UP	3.87798793276534	0.000152513581312919	Melanogenesis: MITF*
hsa04750__60	0.000119119784819511	UP	3.85023846634126	0.000170729272063967	Inflammatory mediator regulation of TRP channels: TRPV3
hsa04664__3 4 5	0.000130875092932717	UP	3.82711391098786	0.000187434679588854	Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A
hsa04919__45	0.000138446805293445	DOWN	-3.81323917777582	0.000198127606356728	Thyroid hormone signaling pathway: SLC9A1
hsa04666__49	0.000143720069654931	UP	3.80398935563446	0.000205517512086465	Fc gamma R-mediated phagocytosis: ARF6*
hsa04022__37 38	0.000146427088444713	UP	3.79936444456378	0.000209229276948757	cGMP-PKG signaling pathway: ATP2A1 PLN
hsa04310__22	0.000149182065042917	UP	3.7947395334931	0.0002130038755438	Wnt signaling pathway: ROCK2
hsa05145__9	0.000157742697724543	UP	3.78086480028106	0.000225055830694317	Toxoplasmosis: MAPK1
hsa04152__15	0.000160697521569477	UP	3.77623988921038	0.000229097604726137	AMPK signaling pathway: FOXO1
hsa05140__62	0.000163704371765035	DOWN	-3.7716149781397	0.000233207365084534	Leishmaniasis: C00584
hsa05100__24	0.000173045649942539	UP	3.75774024492766	0.000246327860789417	Bacterial invasion of epithelial cells: ACTB
hsa04911__25	0.000176269239078089	UP	3.75311533385698	0.000250726646652331	Insulin secretion: PRKCA
hsa05168__123	0.000179549235973953	UP	3.7484904227863	0.000255198951887336	Herpes simplex infection: CYCS
hsa05211__40	0.000207932655864971	UP	3.71149113422086	0.000295317808291973	Renal cell carcinoma: PAK4
hsa04068__14	0.00021565991558319	DOWN	-3.7022413120795	0.000305830174627029	FoxO signaling pathway: G6PC
hsa05010__12	0.00021565991558319	UP	3.7022413120795	0.000305830174627029	Alzheimer's disease: CASP3
hsa03320__47	0.000227757933800447	DOWN	-3.68836657886745	0.000322742954457798	PPAR signaling pathway: PLTP
hsa05215__46	0.000249347115707774	DOWN	-3.66524202351405	0.000353069502950194	Prostate cancer: MTOR
hsa04360__101 103	0.000272844572533314	DOWN	-3.64211746816065	0.000386050415504592	Axon guidance: DPYSL2 DPYSL5
hsa05205__30	0.000277786502412777	DOWN	-3.63749255708997	0.000392747056458697	Proteoglycans in cancer: FLNA
hsa04151__100	0.000320450813300946	DOWN	-3.60049326852453	0.00045238698586963	PI3K-Akt signaling pathway: PRKCA
hsa05162__25 70	0.000320450813300946	UP	3.60049326852453	0.00045238698586963	Measles: IFNAR1 GNB2L1
hsa04010__78	0.000344013679490442	DOWN	-3.58199362424181	0.000484558998322745	MAPK signaling pathway: MAP3K4
hsa04340__46	0.000344013679490442	DOWN	-3.58199362424181	0.000484558998322745	Hedgehog signaling pathway: PRKACA
hsa05014__13	0.000344013679490442	DOWN	-3.58199362424181	0.000484558998322745	Amyotrophic lateral sclerosis (ALS): CASP3
hsa04115__52 53	0.000350152595179059	UP	3.57736871317113	0.000492836499132174	p53 signaling pathway: CDK4 CCND1
hsa04114__56	0.000362739036262755	DOWN	-3.56811889102977	0.000509407062135812	Oocyte meiosis: REC8
hsa04910__57	0.000362739036262755	DOWN	-3.56811889102977	0.000509407062135812	Insulin signaling pathway: GCK
hsa04919__11	0.000362739036262755	DOWN	-3.56811889102977	0.000509407062135812	Thyroid hormone signaling pathway: CTNNB1
hsa04012__47	0.000375747536006204	UP	3.55886906888841	0.000526494869616448	ErbB signaling pathway: PRKCA
hsa04068__55	0.000375747536006204	UP	3.55886906888841	0.000526494869616448	FoxO signaling pathway: ATM
hsa04550__53 64	0.000375747536006204	UP	3.55886906888841	0.000526494869616448	Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4
hsa04261__8 38	0.000389191096958192	UP	3.54961924674705	0.000544519784947463	Adrenergic signaling in cardiomyocytes: ATP2A2 PLN
hsa05012__57	0.000389191096958192	DOWN	-3.54961924674705	0.000544519784947463	Parkinson's disease: CASP3
hsa04390__74	0.000403083080841562	UP	3.54036942460569	0.000563117553086464	Hippo signaling pathway: AXIN1
hsa05169__45	0.000403083080841562	DOWN	-3.54036942460569	0.000563117553086464	Epstein-Barr virus infection: RB1
hsa04550__36	0.000410201507223575	UP	3.53574451353501	0.000572636427988928	Signaling pathways regulating pluripotency of stem cells: AKT3*
hsa05152__94	0.000417437217063009	DOWN	-3.53111960246433	0.000582304774210389	Tuberculosis: CAMP
hsa04151__102	0.000432267611378813	UP	3.52186978032297	0.000601652475393177	PI3K-Akt signaling pathway: C8orf44-SGK3
hsa04540__14 31	0.000432267611378813	UP	3.52186978032297	0.000601652475393177	Gap junction: GJA1 TJP1
hsa04913__40	0.000432267611378813	UP	3.52186978032297	0.000601652475393177	Ovarian steroidogenesis: HSD17B1
hsa05210__40	0.000447588754717919	DOWN	-3.51261995818161	0.000622516114074737	Colorectal cancer: CASP9
hsa04630__24	0.000479763232096266	DOWN	-3.49412031389889	0.000666278723657712	Jak-STAT signaling pathway: MCL1
hsa05134__68	0.000479763232096266	UP	3.49412031389889	0.000666278723657712	Legionellosis: TNF
hsa04913__12	0.000505295972696926	DOWN	-3.48024558068685	0.000701219448077936	Ovarian steroidogenesis: HSD3B1
hsa05200__216	0.000514084625405713	UP	3.47562066961617	0.000712889307112424	Pathways in cancer: IL6
hsa04261__39	0.000550683665218773	DOWN	-3.45712102533345	0.000763078618691795	Adrenergic signaling in cardiomyocytes: SCN1B
hsa05231__18	0.000569880079037934	DOWN	-3.44787120319208	0.000789097029117375	Choline metabolism in cancer: CHKA
hsa05161__92	0.000589698147292445	UP	3.43862138105072	0.000815937274493743	Hepatitis B: NFKBIA
hsa04919__40	0.000610156251125733	DOWN	-3.42937155890936	0.000843622955014903	Thyroid hormone signaling pathway: RCAN2
hsa04520__7 68	0.00063127325402566	DOWN	-3.420121736768	0.000872178267878099	Adherens junction: CDH1 CTNNB1
hsa05200__53	0.000642084871970749	DOWN	-3.41549682569732	0.000886463978275561	Pathways in cancer: BCL2L1
hsa05016__48	0.000664226673857241	UP	3.40624700355596	0.000916359706444755	Huntington's disease: HIP1
hsa04920__37	0.000675561886690551	DOWN	-3.40162209248528	0.000930631074114036	Adipocytokine signaling pathway: IRS1
hsa05016__46	0.000675561886690551	UP	3.40162209248528	0.000930631074114036	Huntington's disease: HTT**
hsa05231__38	0.000698773751740557	DOWN	-3.39237227034392	0.000961901743238467	Choline metabolism in cancer: RPS6KB1
hsa04710__23	0.000772931999036572	UP	3.36462280391984	0.00106242810986812	Circadian rhythm: BHLHE41
hsa04750__8	0.000772931999036572	DOWN	-3.36462280391984	0.00106242810986812	Inflammatory mediator regulation of TRP channels: ASIC2
hsa04068__45	0.000785980031060883	DOWN	-3.35999789284916	0.00107878486366939	FoxO signaling pathway: RBL2
hsa04210__86	0.000785980031060883	UP	3.35999789284916	0.00107878486366939	Apoptosis: BCL2L11
hsa04024__62	0.000812691614793128	DOWN	-3.3507480707078	0.0011146332439389	cAMP signaling pathway: BAD
hsa05321__81	0.000826361018879499	DOWN	-3.34612315963712	0.00113255459844973	Inflammatory bowel disease (IBD): IL13
hsa03320__43	0.000840243460606801	UP	3.34149824856644	0.00114990346866728	PPAR signaling pathway: ILK
hsa04360__81	0.000840243460606801	DOWN	-3.34149824856644	0.00114990346866728	Axon guidance: FYN*
hsa04742__49	0.000868659569147362	UP	3.33224842642508	0.00118792673248027	Taste transduction: HTR1A
hsa04024__21	0.000883199386593031	UP	3.3276235153544	0.00120693210720604	cAMP signaling pathway: AKT3
hsa04932__95	0.000897964543723482	UP	3.32299860428372	0.00122621757097124	Non-alcoholic fatty liver disease (NAFLD): IL1A
hsa04360__125	0.000912958212163395	UP	3.31837369321304	0.00124488278712266	Axon guidance: ENAH*
hsa05216__12	0.000912958212163395	DOWN	-3.31837369321304	0.00124488278712266	Thyroid cancer: CDH1
hsa04912__20	0.000943643966040198	UP	3.30912387107168	0.00128486015376053	GnRH signaling pathway: PLA2G4B
hsa05145__35	0.000943643966040198	UP	3.30912387107168	0.00128486015376053	Toxoplasmosis: CASP3
hsa04151__32	0.000975282813107766	DOWN	-3.29987404893032	0.00132697784636459	PI3K-Akt signaling pathway: BCL2L1
hsa05164__68	0.00100790156531001	UP	3.29062422678896	0.00137036688944827	Influenza A: EIF2S1
hsa04510__42	0.00105872729469104	UP	3.27674949357692	0.00143842992532499	Focal adhesion: BIRC2
hsa04710__11	0.00109391747682209	UP	3.26749967143556	0.00148516686340224	Circadian rhythm: CRY1
hsa04360__123	0.0011487352488693	UP	3.25362493822352	0.00155846464449488	Axon guidance: ENAH
hsa05030__80 81	0.00116756482811672	UP	3.24900002715284	0.00158286746899806	Cocaine addiction: GRIN3A DLG4
hsa04064__134	0.00124577103616249	DOWN	-3.23050038287012	0.00168524389989152	NF-kappa B signaling pathway: CCL21
hsa04630__28	0.00124577103616249	UP	3.23050038287012	0.00168524389989152	Jak-STAT signaling pathway: CCND1
hsa05142__53	0.00124577103616249	UP	3.23050038287012	0.00168524389989152	Chagas disease (American trypanosomiasis): AKT3
hsa04550__9	0.00128666254645989	DOWN	-3.22125056072876	0.00173930857899146	Signaling pathways regulating pluripotency of stem cells: HNF1A
hsa04012__3	0.00130756965273339	UP	3.21662564965807	0.00176630005570528	ErbB signaling pathway: ELK1
hsa04920__12	0.00137216850774804	DOWN	-3.20275091644603	0.00184959740115324	Adipocytokine signaling pathway: C00165
hsa04921__55	0.0013721866829205	UP	3.20275091644603	0.00184959740115324	Oxytocin signaling pathway: PTGS2*
hsa04933__23	0.0013721866829205	DOWN	-3.20275091644603	0.00184959740115324	AGE-RAGE signaling pathway in diabetic complications: F3
hsa04919__88	0.00139437185897162	DOWN	-3.19812600537535	0.00187815392330299	Thyroid hormone signaling pathway: FOXO1
hsa04340__14	0.00141688737443051	DOWN	-3.19350109430467	0.00190711416658662	Hedgehog signaling pathway: PTCH1
hsa04068__39	0.00143973765931533	UP	3.18887618323399	0.00193233361560964	FoxO signaling pathway: CCNB3
hsa04933__52	0.00143973765931533	UP	3.18887618323399	0.00193233361560964	AGE-RAGE signaling pathway in diabetic complications: FOXO1
hsa05215__25	0.00143973765931533	DOWN	-3.18887618323399	0.00193233361560964	Prostate cancer: FOXO1
hsa05217__5	0.00143973765931533	UP	3.18887618323399	0.00193233361560964	Basal cell carcinoma: BMP2
hsa04914__42	0.00148646051510813	DOWN	-3.17962636109263	0.00199361834967036	Progesterone-mediated oocyte maturation: ARAF
hsa04740__16	0.00151034220515145	UP	3.17500145002195	0.00202276051566612	Olfactory transduction: PRKG1
hsa04914__15	0.00151034220515145	UP	3.17500145002195	0.00202276051566612	Progesterone-mediated oocyte maturation: ANAPC10
hsa05150__14	0.00153457690384818	UP	3.17037653895127	0.00205375356291363	Staphylococcus aureus infection: FPR1
hsa04921__41	0.00158412414899041	DOWN	-3.16112671680991	0.0021185546448064	Oxytocin signaling pathway: PTGS2
hsa04742__67	0.00160944624141253	DOWN	-3.15650180573923	0.00215088868251361	Taste transduction: PRKACA
hsa05161__32	0.00163514043541833	DOWN	-3.15187689466855	0.00218367368738525	Hepatitis B: STAT3
hsa04913__35	0.00179739864207671	UP	3.12412742824447	0.00239865912532822	Ovarian steroidogenesis: HSD17B2
hsa05217__22	0.00182583819467832	UP	3.11950251717379	0.00243488287281801	Basal cell carcinoma: LEF1
hsa04068__60	0.00203678332162105	DOWN	-3.08712813967903	0.00271426656831628	FoxO signaling pathway: RAG1
hsa04662__16	0.00213385346584864	UP	3.07325340646699	0.00284160925749794	B cell receptor signaling pathway: VAV3
hsa04730__8	0.00223514893228555	UP	3.05937867325495	0.00297439436527234	Long-term depression: GNA13*
hsa04064__54	0.00234083329632167	UP	3.04550394004291	0.00311282785830744	NF-kappa B signaling pathway: CCL13
hsa05020__49	0.00237706577018437	UP	3.04087902897223	0.00315877410337796	Prion diseases: BAX
hsa04520__44 52 45	0.00241381101629923	DOWN	-3.03625411790155	0.00320307266922758	Adherens junction: ACTB ACTN4 CTNNA1
hsa04725__54	0.00241381101629923	DOWN	-3.03625411790155	0.00320307266922758	Cholinergic synapse: CHRM1*
hsa04670__54	0.00245107549447772	UP	3.03162920683087	0.00325022643198563	Leukocyte transendothelial migration: RAC1*
hsa04360__96	0.00248886573344311	UP	3.02700429576019	0.00329801037597997	Axon guidance: GSK3B
hsa04024__123	0.00252718833138152	UP	3.02237938468951	0.00334407526384921	cAMP signaling pathway: PAK1
hsa05169__93	0.00252718833138152	UP	3.02237938468951	0.00334407526384921	Epstein-Barr virus infection: PLCG1
hsa04921__46	0.00256604995649489	UP	3.01775447361883	0.00339310898540035	Oxytocin signaling pathway: C00942*
hsa04340__32	0.00260545734755558	UP	3.01312956254815	0.00344037551374345	Hedgehog signaling pathway: PTCH1***
hsa04666__38	0.00260545734755558	DOWN	-3.01312956254815	0.00344037551374345	Fc gamma R-mediated phagocytosis: CFL1
hsa04014__55	0.00268593673880084	UP	3.00387974040679	0.00354166675944335	Ras signaling pathway: MLLT4
hsa04340__31	0.00268593673880084	UP	3.00387974040679	0.00354166675944335	Hedgehog signaling pathway: GLI1***
hsa04713__61	0.00272702257439839	DOWN	-2.99925482933611	0.00358828810734914	Circadian entrainment: FOS
hsa04724__68	0.00272702257439839	DOWN	-2.99925482933611	0.00358828810734914	Glutamatergic synapse: MAPK1
hsa04750__40	0.00272702257439839	DOWN	-2.99925482933611	0.00358828810734914	Inflammatory mediator regulation of TRP channels: C00219
hsa04630__27	0.00276868184789028	DOWN	-2.99462991826543	0.00364055506800969	Jak-STAT signaling pathway: PIM1
hsa04921__43	0.00281092165928026	UP	2.99000500719475	0.00369351174670462	Oxytocin signaling pathway: CACNG3
hsa04931__137	0.00285374918250536	UP	2.98538009612407	0.0037471661173498	Insulin resistance: MLXIP*
hsa05132__6	0.00289717166600196	DOWN	-2.98075518505339	0.00380152622934195	Salmonella infection: NFKB1
hsa04064__129	0.003031082491899	UP	2.96688045184134	0.00397446196948933	NF-kappa B signaling pathway: PTGS2
hsa03320__7	0.0030769588107195	DOWN	-2.96225554077066	0.00403180307206551	PPAR signaling pathway: AQP7
hsa04810__82 83	0.00321841271436498	UP	2.94838080755862	0.00420542245500125	Regulation of actin cytoskeleton: ACTB ARPC5
hsa04919__42	0.00321841271436498	UP	2.94838080755862	0.00420542245500125	Thyroid hormone signaling pathway: SLC2A1
hsa04919__91	0.00321841271436498	UP	2.94838080755862	0.00420542245500125	Thyroid hormone signaling pathway: PFKP
hsa05164__53	0.00321841271436498	UP	2.94838080755862	0.00420542245500125	Influenza A: MAPK14
hsa04726__64	0.00331598083143908	UP	2.93913098541726	0.00432689443213475	Serotonergic synapse: CASP3
hsa04740__42	0.00331598083143908	UP	2.93913098541726	0.00432689443213475	Olfactory transduction: PDE2A
hsa05160__37	0.00336565466913766	UP	2.93450607434658	0.00437969444876666	Hepatitis C: STAT3
hsa04360__145	0.0033657683789351	DOWN	-2.93450607434658	0.00437969444876666	Axon guidance: ABLIM3
hsa05200__96	0.0033657683789351	UP	2.93450607434658	0.00437969444876666	Pathways in cancer: C00416
hsa05213__27	0.0033657683789351	UP	2.93450607434658	0.00437969444876666	Endometrial cancer: ELK1
hsa04520__58	0.00357179858254388	DOWN	-2.91600643006386	0.00464457407377159	Adherens junction: CDH1*
hsa04064__55	0.00396013862822525	UP	2.8836320525691	0.00513888154864312	NF-kappa B signaling pathway: CXCL12
hsa04750__7	0.00396013862822525	DOWN	-2.8836320525691	0.00513888154864312	Inflammatory mediator regulation of TRP channels: TRPV1
hsa04750__58	0.00396013862822525	DOWN	-2.8836320525691	0.00513888154864312	Inflammatory mediator regulation of TRP channels: TRPV1**
hsa05152__51	0.0040186421237328	UP	2.87900714149842	0.00520760589689236	Tuberculosis: CASP3
hsa05221__41	0.0040186421237328	DOWN	-2.87900714149842	0.00520760589689236	Acute myeloid leukemia: MAPK1
hsa05152__13	0.00413800899414441	DOWN	-2.86975731935706	0.00535859331495338	Tuberculosis: LAMP1
hsa04930__8	0.00426058421153923	DOWN	-2.8605074972157	0.00551352460983624	Type II diabetes mellitus: C00022
hsa04919__31	0.00432309847674565	DOWN	-2.85588258614502	0.00558672767386869	Thyroid hormone signaling pathway: ATP2A2
hsa05169__79	0.00432309847674565	UP	2.85588258614502	0.00558672767386869	Epstein-Barr virus infection: ATF2
hsa04742__23 45	0.00438541268297064	UP	2.85125767507434	0.00566080140811254	Taste transduction: PKD1L3 PKD2L1
hsa04350__12	0.00438644324119843	DOWN	-2.85125767507434	0.00566080140811254	TGF-beta signaling pathway: ACVR2A
hsa04742__48	0.00451566300071241	UP	2.84200785293298	0.0058195684350745	Taste transduction: GABBR1
hsa04930__13	0.00451566300071241	UP	2.84200785293298	0.0058195684350745	Type II diabetes mellitus: C00162
hsa04152__61	0.00464832187881905	DOWN	-2.83275803079162	0.00598642687477793	AMPK signaling pathway: RPS6KB1
hsa04722__34	0.00471596589072659	UP	2.82813311972094	0.00606522923249505	Neurotrophin signaling pathway: GSK3B
hsa04727__49	0.00471596589072659	UP	2.82813311972094	0.00606522923249505	GABAergic synapse: GABRR3
hsa04973__5	0.00478449975423482	UP	2.82350820865026	0.00614495901449572	Carbohydrate digestion and absorption: SLC2A5
hsa05205__45 46	0.00478449975423482	UP	2.82350820865026	0.00614495901449572	Proteoglycans in cancer: PAK1 FLNA
hsa04925__3	0.00529002328903201	UP	2.7911338311555	0.00678495137207586	Aldosterone synthesis and secretion: ITPR1
hsa05166__114 112 113	0.00529002328903201	UP	2.7911338311555	0.00678495137207586	HTLV-I infection: DLG1 CTNNB1 APC2
hsa05132__48	0.00536605200550193	DOWN	-2.78650892008482	0.00687777061278181	Salmonella infection: KLC3
hsa05134__69	0.00544306604645791	UP	2.78188400901414	0.00696697622703979	Legionellosis: IL1B*
hsa05220__25	0.00544306604645791	DOWN	-2.78188400901414	0.00696697622703979	Chronic myeloid leukemia: BCL2L1*
hsa04664__46	0.00552107651296243	UP	2.77725909794346	0.00705241520588471	Fc epsilon RI signaling pathway: PLA2G4B
hsa04914__23	0.00552107651296243	UP	2.77725909794346	0.00705241520588471	Progesterone-mediated oocyte maturation: PRKACA
hsa05161__31	0.00552107651296243	DOWN	-2.77725909794346	0.00705241520588471	Hepatitis B: ELK1
hsa04920__40	0.00560009460680417	DOWN	-2.77263418687278	0.00714849033028875	Adipocytokine signaling pathway: PPARGC1A
hsa04622__9 35	0.00576119899075601	DOWN	-2.76338436473142	0.00734914657408727	RIG-I-like receptor signaling pathway: IRF3 PIN1
hsa04664__23	0.00584330819327637	UP	2.75875945366074	0.0074488304580504	Fc epsilon RI signaling pathway: AKT3
hsa05222__36	0.00644823261602445	UP	2.72638507616597	0.00821439260034572	Small cell lung cancer: PTGS2
hsa04110__46	0.00653910331284952	UP	2.72176016509529	0.0083245088921709	Cell cycle: RB1
hsa04910__32	0.00672430761388693	UP	2.71251034295393	0.00855448477081486	Insulin signaling pathway: EIF4E
hsa04022__65	0.00701096141782911	UP	2.69863560974189	0.00890709702778965	cGMP-PKG signaling pathway: PDE2A
hsa05200__187	0.00701096141782911	DOWN	-2.69863560974189	0.00890709702778965	Pathways in cancer: WNT16*
hsa04921__80	0.00720811258835407	UP	2.68938578760053	0.00915138077940358	Oxytocin signaling pathway: KCNJ2
hsa04068__59	0.00730854210151498	UP	2.68476087652985	0.00926636343370219	FoxO signaling pathway: S1PR1
hsa05161__69	0.00730854210151498	DOWN	-2.68476087652985	0.00926636343370219	Hepatitis B: SMAD4
hsa05020__59	0.00751317566262212	DOWN	-2.67551105438849	0.00951939114637017	Prion diseases: CCL5
hsa04024__59	0.00772293215716811	UP	2.66626123224713	0.00977856436881327	cAMP signaling pathway: MLLT4
hsa05200__199	0.00793792144112617	DOWN	-2.65701141010577	0.010037250597494	Pathways in cancer: BCL2L1**
hsa05220__3	0.00793792144112617	DOWN	-2.65701141010577	0.010037250597494	Chronic myeloid leukemia: BCL2L1
hsa05212__10	0.00815825520449291	DOWN	-2.64776158796441	0.010308918311528	Pancreatic cancer: BCL2L1
hsa04330__12	0.00827046167467126	UP	2.64313667689373	0.0104366672173991	Notch signaling pathway: HES1
hsa05217__10	0.00827046167467126	UP	2.64313667689373	0.0104366672173991	Basal cell carcinoma: PTCH1*
hsa04152__35	0.00861541219922722	DOWN	-2.62926194368169	0.0108646708203678	AMPK signaling pathway: PFKFB1
hsa04918__10	0.00885246812940379	DOWN	-2.62001212154033	0.0111561285145203	Thyroid hormone synthesis: TG
hsa04622__21 22 23	0.00897316728641038	UP	2.61538721046965	0.0113006577286629	RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG
hsa04520__43	0.00921898337443198	DOWN	-2.60613738832829	0.011594691941471	Adherens junction: ACTB
hsa05205__121	0.00921898337443198	UP	2.60613738832829	0.011594691941471	Proteoglycans in cancer: PLAUR
hsa04668__111	0.00972871642580992	UP	2.58763774404557	0.0122275974341785	TNF signaling pathway: BAG4
hsa04115__58	0.0102634204640325	UP	2.56913809976285	0.012891020756629	p53 signaling pathway: CASP3
hsa04010__54	0.0105404576630457	DOWN	-2.55988827762149	0.013221308377078	MAPK signaling pathway: NR4A1
hsa04152__81	0.0105404576630457	UP	2.55988827762149	0.013221308377078	AMPK signaling pathway: LIPE
hsa04261__15 16	0.0106814549376203	DOWN	-2.55526336655081	0.0133892287043286	Adrenergic signaling in cardiomyocytes: ACTC1 TPM1
hsa04726__16	0.0109684902174258	UP	2.54601354440945	0.013730708273513	Serotonergic synapse: ITPR1
hsa04726__46	0.0109684902174258	UP	2.54601354440945	0.013730708273513	Serotonergic synapse: ITPR1*
hsa03320__28	0.0112623591173471	DOWN	-2.53676372226809	0.0140891962593177	PPAR signaling pathway: ACSL1
hsa04310__36	0.0114118988926103	UP	2.53213881119741	0.0142667718025381	Wnt signaling pathway: MYC
hsa05168__39 40	0.0120278322271048	DOWN	-2.51363916691469	0.0150267930550066	Herpes simplex infection: POU2F3 HCFC2
hsa05032__25	0.0121863472737604	UP	2.50901425584401	0.0152147153005952	Morphine addiction: C00575*
hsa04360__111	0.0123467107191097	DOWN	-2.50438934477333	0.0153944720910466	Axon guidance: RHOA***
hsa05221__21	0.0123467107191097	DOWN	-2.50438934477333	0.0153944720910466	Acute myeloid leukemia: PIM1
hsa04622__44	0.0128390729340049	UP	2.49051461156128	0.0159977573229411	RIG-I-like receptor signaling pathway: MAPK8
hsa04270__10 3 71	0.0130070121129829	UP	2.4858897004906	0.0161855468611224	Vascular smooth muscle contraction: ACTA2 MYL9 MYH11
hsa05140__16	0.0130070121129829	UP	2.4858897004906	0.0161855468611224	Leishmaniasis: STAT1
hsa05100__33	0.0131768914134079	UP	2.48126478941992	0.0163860879985397	Bacterial invasion of epithelial cells: DNM1
hsa04810__48	0.0133487295729631	DOWN	-2.47663987834924	0.0165887981928556	Regulation of actin cytoskeleton: IQGAP2
hsa04014__33	0.0136983580794008	DOWN	-2.46739005620788	0.0170120388838031	Ras signaling pathway: BCL2L1
hsa05166__99	0.0140560501747277	UP	2.45814023406652	0.0174447280570102	HTLV-I infection: JUN
hsa04340__20 22	0.0146080464588546	UP	2.44426550085448	0.0181058834407571	Hedgehog signaling pathway: GLI1 SUFU*
hsa04910__18	0.0146080464588546	UP	2.44426550085448	0.0181058834407571	Insulin signaling pathway: LIPE
hsa03320__65	0.0153737254977171	DOWN	-2.42576585657176	0.0190297959224048	PPAR signaling pathway: ME1
hsa04920__31	0.0153737254977171	DOWN	-2.42576585657176	0.0190297959224048	Adipocytokine signaling pathway: AGRP
hsa04213__53	0.0155705797587617	UP	2.42114094550108	0.0192607764099495	Longevity regulating pathway - multiple species: SOD1
hsa04010__13	0.0163803489708664	DOWN	-2.40264130121836	0.0202358157240355	MAPK signaling pathway: STMN1
hsa04360__20	0.0163803489708664	DOWN	-2.40264130121836	0.0202358157240355	Axon guidance: ROCK1
hsa04022__39	0.0170117302322395	UP	2.38876656800632	0.0210019980988029	cGMP-PKG signaling pathway: KCNJ8
hsa05152__9	0.0178867370107836	DOWN	-2.3702669237236	0.0220677471065412	Tuberculosis: TCIRG1
hsa04068__47	0.0197557231813309	DOWN	-2.33326763515816	0.0243256906013898	FoxO signaling pathway: GADD45G
hsa04068__54	0.0197557231813309	DOWN	-2.33326763515816	0.0243256906013898	FoxO signaling pathway: GADD45G*
hsa05031__55	0.0197557231813309	DOWN	-2.33326763515816	0.0243256906013898	Amphetamine addiction: GRIA1*
hsa04520__73	0.0200009384671949	DOWN	-2.32864272408748	0.0245793089469322	Adherens junction: PARD3
hsa04723__7	0.0200009384671949	UP	2.32864272408748	0.0245793089469322	Retrograde endocannabinoid signaling: ITPR1
hsa05205__91	0.0200009384671949	UP	2.32864272408748	0.0245793089469322	Proteoglycans in cancer: RAC1*
hsa04152__64	0.0202488062806855	DOWN	-2.3240178130168	0.0248676516349072	AMPK signaling pathway: ACACB
hsa04728__70 73	0.0204993499554329	UP	2.31939290194612	0.0251589017415144	Dopaminergic synapse: KIF5A GRIA1
hsa04723__46	0.0210085589072305	DOWN	-2.31014307980476	0.0256665033723577	Retrograde endocannabinoid signaling: ADCY1
hsa04723__40	0.0210085589072305	DOWN	-2.31014307980476	0.0256665033723577	Retrograde endocannabinoid signaling: GRIA1
hsa04724__4	0.0210085589072305	DOWN	-2.31014307980476	0.0256665033723577	Glutamatergic synapse: GRIA1
hsa05031__12	0.0210085589072305	DOWN	-2.31014307980476	0.0256665033723577	Amphetamine addiction: GRIA1
hsa05145__11	0.0210085589072305	DOWN	-2.31014307980476	0.0256665033723577	Toxoplasmosis: MAPK14
hsa05214__23	0.0210085589072305	UP	2.31014307980476	0.0256665033723577	Glioma: MAPK1
hsa05214__56	0.0210085589072305	UP	2.31014307980476	0.0256665033723577	Glioma: MAPK1*
hsa04530__11 36 14	0.0212672715354235	DOWN	-2.30551816873408	0.0259656940968556	Tight junction: TJP1 CTNNB1 CTNNA1
hsa04630__35	0.0223300685365474	DOWN	-2.28701852445136	0.0272455836234887	Jak-STAT signaling pathway: MTOR
hsa04550__60	0.0226028755179982	DOWN	-2.28239361338068	0.0275605471111737	Signaling pathways regulating pluripotency of stem cells: MAPK14
hsa04024__76	0.0231571902188103	UP	2.27314379123932	0.0282181325688356	cAMP signaling pathway: C00416
hsa04350__41	0.0234387474710276	DOWN	-2.26851888016864	0.0285427132197413	TGF-beta signaling pathway: SMAD4***
hsa04024__31	0.0243013188815248	DOWN	-2.25464414695659	0.02955480788245	cAMP signaling pathway: C00165
hsa04024__32	0.0243013188815248	DOWN	-2.25464414695659	0.02955480788245	cAMP signaling pathway: C01245
hsa04710__5	0.0248915356126263	UP	2.24539432481523	0.0302530371385025	Circadian rhythm: RORA
hsa04211__42	0.0251912712478056	DOWN	-2.24076941374455	0.0305975427761	Longevity regulating pathway - mammal: PPARGC1A
hsa04666__42	0.0254941260578816	UP	2.23614450267387	0.0309453894462271	Fc gamma R-mediated phagocytosis: MYO10
hsa04310__14	0.0258001259569625	UP	2.23151959160319	0.0312361061038225	Wnt signaling pathway: PRKCA
hsa04921__23	0.0258001259569625	UP	2.23151959160319	0.0312361061038225	Oxytocin signaling pathway: C00219
hsa04922__59	0.0258001259569625	DOWN	-2.23151959160319	0.0312361061038225	Glucagon signaling pathway: CPT1C
hsa05016__12	0.0258001259569625	DOWN	-2.23151959160319	0.0312361061038225	Huntington's disease: REST
hsa04024__43	0.0264216653476327	UP	2.22226976946183	0.0319680033407611	cAMP signaling pathway: MAPK8
hsa04728__44	0.0267372573356107	UP	2.21764485839115	0.0323082357129341	Dopaminergic synapse: FOS
hsa05210__39	0.0267372573356107	UP	2.21764485839115	0.0323082357129341	Colorectal cancer: BAD
hsa04024__91	0.0270560994047446	UP	2.21301994732047	0.0326725005022591	cAMP signaling pathway: GRIA1
hsa05205__189	0.0280323925640667	UP	2.19914521410843	0.0338297145972263	Proteoglycans in cancer: IL12B
hsa04213__2	0.028364502082671	UP	2.19452030303775	0.0342085362088182	Longevity regulating pathway - multiple species: RPS6KB1
hsa04932__28	0.0286999959033859	UP	2.18989539196707	0.0345909508033753	Non-alcoholic fatty liver disease (NAFLD): GSK3A
hsa05020__62	0.0297270562085692	DOWN	-2.17602065875503	0.0358058580871164	Prion diseases: NOTCH1
hsa04930__7	0.0304291874171723	DOWN	-2.16677083661367	0.0366280865835149	Type II diabetes mellitus: C00002
hsa04014__100	0.0307855635915895	UP	2.16214592554299	0.0370096442665366	Ras signaling pathway: REL
hsa04068__68	0.0307855635915895	UP	2.16214592554299	0.0370096442665366	FoxO signaling pathway: ATG12
hsa04725__53	0.031876270928803	UP	2.14827119233095	0.0382963638588368	Cholinergic synapse: CHRNA7
hsa05205__284	0.032247127202005	UP	2.14364628126027	0.0387171578355064	Proteoglycans in cancer: PRKCA*
hsa05200__184	0.0329999414145124	UP	2.13439645911891	0.0395704466610522	Pathways in cancer: GLI1
hsa05205__113	0.0329999414145124	UP	2.13439645911891	0.0395704466610522	Proteoglycans in cancer: TP53
hsa04621__21 30	0.0333819567668169	UP	2.12977154804823	0.0400029953857455	NOD-like receptor signaling pathway: NLRP3 PYCARD
hsa05200__186	0.0341573484264473	DOWN	-2.12052172590687	0.0409060915827243	Pathways in cancer: PTCH1*
hsa04933__19	0.0361634624407111	UP	2.09739717055347	0.0432809846663033	AGE-RAGE signaling pathway in diabetic complications: TGFBR2
hsa05031__97	0.0374146903018455	UP	2.08352243734143	0.04474997013187	Amphetamine addiction: ARC
hsa04068__49	0.0378398719849879	DOWN	-2.07889752627075	0.0452009659629957	FoxO signaling pathway: BCL2L11
hsa04810__35 81 80	0.0378398719849879	UP	2.07889752627075	0.0452009659629957	Regulation of actin cytoskeleton: MYL12B MYH9 ACTB
hsa04072__27	0.0400279353925289	DOWN	-2.05577297091735	0.0477843015264052	Phospholipase D signaling pathway: C01245
hsa04330__19	0.0418548102886777	DOWN	-2.03727332663463	0.0498701258924701	Notch signaling pathway: DTX2
hsa04390__17 51	0.0418548102886777	UP	2.03727332663463	0.0498701258924701	Hippo signaling pathway: YWHAQ YAP1
hsa05014__54	0.0418548102886777	UP	2.03727332663463	0.0498701258924701	Amyotrophic lateral sclerosis (ALS): PPP3CA
hsa04550__25	0.0427944037794588	UP	2.02802350449327	0.0509250694753661	Signaling pathways regulating pluripotency of stem cells: MAPK1
hsa05161__10	0.0427944037794588	UP	2.02802350449327	0.0509250694753661	Hepatitis B: CASP3
hsa04024__112	0.0437517687215205	UP	2.0187736823519	0.051998465166184	cAMP signaling pathway: GLI1
hsa04950__5	0.0437517687215205	DOWN	-2.0187736823519	0.051998465166184	Maturity onset diabetes of the young: GCK
hsa04390__79	0.0462245933752645	UP	1.9956491269985	0.0549026617902161	Hippo signaling pathway: SNAI2
hsa04931__149	0.0472461588931151	DOWN	-1.98639930485714	0.0560805638409118	Insulin resistance: ACACB*
hsa04630__7	0.0477640208966186	UP	1.98177439378646	0.0566594667075419	Jak-STAT signaling pathway: BCL2
hsa04014__67	0.0482866456006573	UP	1.97714948271578	0.0572071923604257	Ras signaling pathway: RAPGEF5*
hsa04024__110	0.0482866456006573	UP	1.97714948271578	0.0572071923604257	cAMP signaling pathway: FOS
hsa05010__61	0.052643021957551	DOWN	-1.94015019415034	0.0623290726264892	Alzheimer's disease: GAPDH
hsa04918__14	0.0532099851900879	UP	1.93552528307966	0.0629606814686242	Thyroid hormone synthesis: DUOX2
hsa04666__40	0.0537820403255957	UP	1.93090037200898	0.0635975165335395	Fc gamma R-mediated phagocytosis: PLA2G6
hsa04152__54	0.0555290913883476	DOWN	-1.91702563879694	0.0655808690878096	AMPK signaling pathway: SLC2A4*
hsa04620__20	0.0555290913883476	UP	1.91702563879694	0.0655808690878096	Toll-like receptor signaling pathway: IFNB1*
hsa04922__24	0.0567145529538453	UP	1.90777581665558	0.0669030933580848	Glucagon signaling pathway: PFKL
hsa04210__62	0.0567198657367904	DOWN	-1.90777581665558	0.0669030933580848	Apoptosis: TP53AIP1
hsa04024__118	0.0579318136126434	UP	1.89852599451422	0.0682897602121436	cAMP signaling pathway: MYL9
hsa04340__26	0.0585458122554527	DOWN	-1.89390108344354	0.0689270559072654	Hedgehog signaling pathway: PTCH1**
hsa04630__30	0.0585458122554527	UP	1.89390108344354	0.0689270559072654	Jak-STAT signaling pathway: CDKN1A
hsa04064__93	0.059165205977116	DOWN	-1.88927617237286	0.0696126625115848	NF-kappa B signaling pathway: PLAU
hsa04610__57	0.0610560983439471	DOWN	-1.87540143916082	0.0717924961128139	Complement and coagulation cascades: PLAUR
hsa03320__40	0.0623442944294016	UP	1.86615161701946	0.0732155807705285	PPAR signaling pathway: FABP4
hsa04068__96	0.0623442944294016	DOWN	-1.86615161701946	0.0732155807705285	FoxO signaling pathway: CCNG2
hsa05133__46	0.0636548916333111	UP	1.8569017948781	0.0747080208488392	Pertussis: CFL1
hsa04727__35	0.0643186767041315	UP	1.85227688380742	0.0754399460218871	GABAergic synapse: PRKACA
hsa04931__144	0.0677238488304598	DOWN	-1.82915232845402	0.079384349315305	Insulin resistance: C00533*
hsa05161__78	0.0684223752466065	UP	1.82452741738334	0.0801531440700584	Hepatitis B: TNF
hsa05152__81	0.0691268134168789	DOWN	-1.81990250631266	0.0809279018132807	Tuberculosis: IFNA1
hsa04066__56	0.0705535644068526	DOWN	-1.8106526841713	0.08249542471716	HIF-1 signaling pathway: TEK
hsa04919__18	0.0705535644068526	UP	1.8106526841713	0.08249542471716	Thyroid hormone signaling pathway: STAT1
hsa04310__34	0.0712759470147028	UP	1.80602777310062	0.0832882490302404	Wnt signaling pathway: FOSL1
hsa04919__49	0.0727389011900564	UP	1.79677795095926	0.084944931843453	Thyroid hormone signaling pathway: ACTB
hsa04015__14	0.0742263406635041	UP	1.7875281288179	0.086628132985543	Rap1 signaling pathway: MAPK14
hsa04724__65	0.075737149267229	UP	1.77827830667653	0.0882833298148651	Glutamatergic synapse: GRM3
hsa04022__48	0.0757385458550093	UP	1.77827830667653	0.0882833298148651	cGMP-PKG signaling pathway: SLC8A2
hsa04723__67	0.0780539037406515	DOWN	-1.76440357346449	0.0909257812329102	Retrograde endocannabinoid signaling: PRKACA
hsa04024__108	0.0796292525006125	DOWN	-1.75515375132313	0.0927034482333649	cAMP signaling pathway: AMH
hsa04919__87	0.0820406446653603	UP	1.74127901811109	0.0954516231122055	Thyroid hormone signaling pathway: BAD
hsa04152__60	0.0836808962688909	DOWN	-1.73202919596973	0.0972997550057216	AMPK signaling pathway: EEF2
hsa04925__18	0.0853476020713818	UP	1.72277937382837	0.0991763415535723	Aldosterone synthesis and secretion: PDE2A
hsa04390__89	0.0861909633506348	UP	1.71815446275769	0.0999708766270635	Hippo signaling pathway: ID2
hsa04650__119	0.0861909633506348	UP	1.71815446275769	0.0999708766270635	Natural killer cell mediated cytotoxicity: KLRC4-KLRK1
hsa05205__236	0.0861909633506348	UP	1.71815446275769	0.0999708766270635	Proteoglycans in cancer: ITGAV
hsa04713__60	0.0896319525185024	DOWN	-1.69965481847497	0.10389786476389	Circadian entrainment: PER1
hsa04068__67	0.0905092617617222	DOWN	-1.69502990740429	0.104720999292042	FoxO signaling pathway: GABARAP
hsa05200__192	0.0905092617617222	DOWN	-1.69502990740429	0.104720999292042	Pathways in cancer: PTGS2
hsa05212__14	0.0905092617617222	UP	1.69502990740429	0.104720999292042	Pancreatic cancer: MAPK1
hsa04340__33	0.0922846006923005	DOWN	-1.68578008526293	0.106709393662051	Hedgehog signaling pathway: HHIP*
hsa04730__7	0.0968454549730382	UP	1.66265552990953	0.111914274227761	Long-term depression: GNA13
hsa04727__8	0.0996673728954507	UP	1.64878079669749	0.115104482895238	GABAergic synapse: ADCY1
hsa05215__22	0.103407996668879	UP	1.63028115241477	0.119351121462423	Prostate cancer: C16038
hsa04919__103	0.104515934367153	DOWN	-1.62565624134409	0.120555826074819	Thyroid hormone signaling pathway: CCND1
hsa03320__32	0.105507763882515	DOWN	-1.62103133027341	0.121550636624921	PPAR signaling pathway: FABP3
hsa05132__86	0.105507763882515	UP	1.62103133027341	0.121550636624921	Salmonella infection: MYH9
hsa04921__57	0.106507046511468	UP	1.61640641920273	0.122551586279883	Oxytocin signaling pathway: FOS
hsa05212__54	0.106507046511468	UP	1.61640641920273	0.122551586279883	Pancreatic cancer: C00416
hsa04724__36	0.109549957478042	DOWN	-1.60253168599069	0.125898697309627	Glutamatergic synapse: TRPC1
hsa05100__55	0.109549957478042	UP	1.60253168599069	0.125898697309627	Bacterial invasion of epithelial cells: ACTB*
hsa03320__9	0.110579396632673	DOWN	-1.59790677492001	0.127004086963809	PPAR signaling pathway: PCK1
hsa04068__50	0.111616460600234	UP	1.59328186384933	0.128116878111081	FoxO signaling pathway: TNFSF10
hsa04630__33	0.113713599411639	DOWN	-1.58403204170797	0.130444354880629	Jak-STAT signaling pathway: RAF1
hsa04550__47	0.115841646002621	DOWN	-1.57478221956661	0.132804425161027	Signaling pathways regulating pluripotency of stem cells: CTNNB1*
hsa04010__119	0.116917344385871	DOWN	-1.57015730849593	0.133955908598202	MAPK signaling pathway: NFATC3
hsa04370__38	0.118000871146028	DOWN	-1.56553239742525	0.135114952396945	VEGF signaling pathway: BAD
hsa04950__22	0.123537104179032	DOWN	-1.54240784207184	0.141367977315714	Maturity onset diabetes of the young: NR5A2
hsa04261__20	0.124668303974192	DOWN	-1.53778293100116	0.142488894870747	Adrenergic signaling in cardiomyocytes: ATP1B4
hsa05168__138	0.124668303974192	DOWN	-1.53778293100116	0.142488894870747	Herpes simplex infection: CHUK
hsa04024__101	0.125807565464337	DOWN	-1.53315801993048	0.143703596053185	cAMP signaling pathway: HCN4
hsa05134__71	0.128110405060522	UP	1.52390819778912	0.146245110029599	Legionellosis: CXCL8
hsa04728__60	0.132814264903712	UP	1.5054085535064	0.151522770949651	Dopaminergic synapse: CACNA1A
hsa04913__19	0.13401087320054	DOWN	-1.50078364243572	0.152795164286295	Ovarian steroidogenesis: STAR
hsa04713__14	0.136429086625386	DOWN	-1.49153382029436	0.155458007137113	Circadian entrainment: PRKCA
hsa04973__36	0.145158622294603	UP	1.4591594427996	0.165304879570642	Carbohydrate digestion and absorption: SLC2A2
hsa05142__29	0.146439866232516	UP	1.45453453172892	0.166562051241463	Chagas disease (American trypanosomiasis): NOS2
hsa05162__62	0.146439866232516	DOWN	-1.45453453172892	0.166562051241463	Measles: IL12A
hsa04724__13	0.147729261319262	DOWN	-1.44990962065824	0.167926970368356	Glutamatergic synapse: GRM5
hsa04360__114	0.149028287394907	DOWN	-1.44528470958756	0.169301180178374	Axon guidance: RAF1
hsa03320__8	0.150335525272946	DOWN	-1.44065979851688	0.170683052560644	PPAR signaling pathway: GK
hsa04360__33 134	0.151651488168798	DOWN	-1.4360348874462	0.172073155959645	Axon guidance: NCK1 PAK4
hsa04270__46	0.15973215267956	DOWN	-1.40828542102212	0.181132597999332	Vascular smooth muscle contraction: ITPR1*
hsa04917__31	0.171007503315192	DOWN	-1.37128613245668	0.193801627701595	Prolactin signaling pathway: GALT
hsa05032__38	0.173917326343455	UP	1.36203631031532	0.196980504038186	Morphine addiction: CACNA1A
hsa04722__33	0.176863977659403	UP	1.35278648817396	0.200197237362661	Neurotrophin signaling pathway: BAD
hsa04740__33	0.179847668090388	UP	1.3435366660326	0.203329583839855	Olfactory transduction: CNGA3*
hsa05169__83	0.179847668090388	DOWN	-1.3435366660326	0.203329583839855	Epstein-Barr virus infection: GSK3B
hsa05120__53	0.184393104064561	UP	1.32966193282056	0.208343140431336	Epithelial cell signaling in Helicobacter pylori infection: GIT1
hsa05020__46	0.185926990869134	DOWN	-1.32503702174988	0.209950009521096	Prion diseases: PRKACA
hsa04010__64	0.187470289944484	UP	1.3204121106792	0.211565570453865	MAPK signaling pathway: DDIT3
hsa04151__28	0.190585222823766	UP	1.31116228853784	0.214951760915881	PI3K-Akt signaling pathway: BCL2L11
hsa04015__95	0.192156904945555	UP	1.30653737746715	0.216594375760467	Rap1 signaling pathway: THBS1
hsa04211__57	0.193738095967597	DOWN	-1.30191246639647	0.218114968438056	Longevity regulating pathway - mammal: ATG5
hsa04728__64	0.193738095967597	UP	1.30191246639647	0.218114968438056	Dopaminergic synapse: SCN1A
hsa04725__50	0.195328819394529	UP	1.29728755532579	0.219642640121077	Cholinergic synapse: BCL2
hsa05160__55	0.195328819394529	UP	1.29728755532579	0.219642640121077	Hepatitis C: MAPK14
hsa05168__79	0.196929098463668	DOWN	-1.29266264425511	0.221309674649062	Herpes simplex infection: EIF2S1
hsa04350__50	0.203426226378921	DOWN	-1.27416299997239	0.228474524426773	TGF-beta signaling pathway: AMHR2
hsa05134__59	0.205074622645794	UP	1.26953808890171	0.230188301046265	Legionellosis: HSPA1A
hsa04360__131	0.211765311834783	DOWN	-1.25103844461899	0.237556430410482	Axon guidance: RAC1****
hsa05031__8	0.213461818313623	UP	1.24641353354831	0.239316680555666	Amphetamine addiction: DRD1
hsa05120__19	0.223851008522171	UP	1.21866406712423	0.250814576632773	Epithelial cell signaling in Helicobacter pylori infection: CXCL1
hsa04068__66	0.225617014834091	DOWN	-1.21403915605355	0.252492180389075	FoxO signaling pathway: BNIP3
hsa04360__108	0.225617014834091	DOWN	-1.21403915605355	0.252492180389075	Axon guidance: CFL1
hsa05212__19	0.227392945837798	DOWN	-1.20941424498287	0.254328181684061	Pancreatic cancer: MAPK8
hsa04520__34	0.230974651894333	UP	1.20016442284151	0.258180470499377	Adherens junction: RHOA
hsa05200__183	0.232780461110803	UP	1.19553951177083	0.260044284439476	Pathways in cancer: BMP2
hsa03320__30	0.236422074828714	UP	1.18628968962947	0.263798740263155	PPAR signaling pathway: LPL
hsa04152__68	0.236422074828714	DOWN	-1.18628968962947	0.263798740263155	AMPK signaling pathway: PPARGC1A**
hsa05205__215 216	0.238257911481109	UP	1.18166477855879	0.265689386156086	Proteoglycans in cancer: EIF4B RPS6
hsa03320__27	0.241959722184195	UP	1.17241495641743	0.269497521033848	PPAR signaling pathway: CPT1C
hsa05160__58	0.241959722184195	UP	1.17241495641743	0.269497521033848	Hepatitis C: EIF3E
hsa04022__3	0.243825726320966	UP	1.16779004534675	0.27141501170444	cGMP-PKG signaling pathway: MYL9
hsa04540__21	0.249484307011352	DOWN	-1.15391531213471	0.277549445159462	Gap junction: C03758
hsa04911__24	0.251390736020028	DOWN	-1.14929040106403	0.279504847918126	Insulin secretion: INS
hsa04630__36	0.253307304859759	DOWN	-1.14466548999335	0.281302852146269	Jak-STAT signaling pathway: GFAP
hsa04930__10	0.253307304859759	UP	1.14466548999335	0.281302852146269	Type II diabetes mellitus: C00031
hsa04310__33	0.263042678739173	UP	1.12154093463995	0.29194163812812	Wnt signaling pathway: CCND1
hsa04664__30	0.265020340679806	DOWN	-1.11691602356927	0.293962939868569	Fc epsilon RI signaling pathway: PRKCA
hsa05161__48	0.267008223657368	DOWN	-1.11229111249859	0.295993187169437	Hepatitis B: STAT1
hsa04152__24	0.269006337757012	UP	1.10766620142791	0.298032375380558	AMPK signaling pathway: SIRT1
hsa04670__76	0.271014692676993	UP	1.10304129035723	0.299903773580724	Leukocyte transendothelial migration: CDC42
hsa05218__14	0.271014692676993	DOWN	-1.10304129035723	0.299903773580724	Melanoma: BAD
hsa05215__34	0.273033297726054	UP	1.09841637928655	0.301959721263835	Prostate cancer: BAD
hsa04530__5 11 31	0.277101293483328	DOWN	-1.08916655714519	0.306278429679514	Tight junction: IGSF5 TJP1 MLLT4
hsa04340__13	0.283280373123253	DOWN	-1.07529182393315	0.312924057083241	Hedgehog signaling pathway: GLI1*
hsa05031__98	0.287451235633856	UP	1.06604200179178	0.317344813017636	Amphetamine addiction: FOS
hsa04340__17	0.289552129243821	DOWN	-1.0614170907211	0.319288996977195	Hedgehog signaling pathway: SMO
hsa05221__26	0.289552129243821	UP	1.0614170907211	0.319288996977195	Acute myeloid leukemia: BAD
hsa04261__3	0.29378486961615	UP	1.05216726857974	0.323008642486101	Adrenergic signaling in cardiomyocytes: RYR2
hsa04723__10	0.29378486961615	DOWN	-1.05216726857974	0.323008642486101	Retrograde endocannabinoid signaling: CACNA1A
hsa04723__21	0.29378486961615	DOWN	-1.05216726857974	0.323008642486101	Retrograde endocannabinoid signaling: CACNA1A*
hsa05162__105	0.29378486961615	DOWN	-1.05216726857974	0.323008642486101	Measles: GSK3B
hsa05221__6	0.29378486961615	DOWN	-1.05216726857974	0.323008642486101	Acute myeloid leukemia: CEBPA
hsa03320__56	0.302374296022278	UP	1.03366762429702	0.332258071477111	PPAR signaling pathway: FADS2
hsa04520__44 49	0.304547497443933	UP	1.02904271322634	0.33445046621692	Adherens junction: ACTB VCL
hsa04022__58	0.313343764520954	UP	1.01054306894362	0.343708659389884	cGMP-PKG signaling pathway: MYH7
hsa04068__53	0.313343764520954	UP	1.01054306894362	0.343708659389884	FoxO signaling pathway: SOD2
hsa05140__26	0.326848671365883	UP	0.982793602519541	0.358313100056297	Leishmaniasis: C00533
hsa04110__60 10 11 12 13 14 9	0.329135712171308	DOWN	-0.978168691448861	0.360609914384774	Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6
hsa05217__4	0.331433098269217	DOWN	-0.973543780378181	0.362915379748169	Basal cell carcinoma: PTCH1
hsa04520__44 47	0.333740827093618	UP	0.968918869307501	0.36522947822301	Adherens junction: ACTB TJP1
hsa05160__66	0.336058895623521	UP	0.964293958236821	0.367552191429916	Hepatitis C: GSK3B
hsa04972__21	0.340726037429802	DOWN	-0.95504413609546	0.37222338623872	Pancreatic secretion: KCNQ1
hsa05231__17	0.340726037429802	UP	0.95504413609546	0.37222338623872	Choline metabolism in cancer: SLC44A3
hsa04024__77	0.347804196040468	DOWN	-0.94116940288342	0.379514566991893	cAMP signaling pathway: RHOA*
hsa04915__40	0.347804196040468	DOWN	-0.94116940288342	0.379514566991893	Estrogen signaling pathway: CREB3**
hsa05010__37	0.357386073125269	DOWN	-0.922669758600699	0.389743721069287	Alzheimer's disease: MAPT
hsa04010__129	0.359807271173789	UP	0.918044847530019	0.392156532793242	MAPK signaling pathway: FOS
hsa04740__37	0.362238745160536	UP	0.913419936459338	0.394577740380664	Olfactory transduction: CNGB1*
hsa04530__11 20 16	0.367132486007529	DOWN	-0.904170114317978	0.399676675091627	Tight junction: TJP1 ACTB CTTN
hsa04068__88	0.387116529095105	UP	0.867170825752536	0.421188163387205	FoxO signaling pathway: FBXO32
hsa04010__14	0.392214340145176	DOWN	-0.857921003611176	0.426487699729621	MAPK signaling pathway: MAPT
hsa05161__207	0.397352656211278	UP	0.848671181469816	0.431575515041036	Hepatitis B: CDK2
hsa05161__219	0.397352656211278	UP	0.848671181469816	0.431575515041036	Hepatitis B: CDK2*
hsa04650__14	0.399936966037645	DOWN	-0.844046270399135	0.434131461111921	Natural killer cell mediated cytotoxicity: CSF2
hsa04727__13	0.407750310438066	UP	0.830171537187095	0.442357294060696	GABAergic synapse: CACNA1A
hsa04920__1	0.410374840590282	UP	0.825546626116415	0.444947677708679	Adipocytokine signaling pathway: C00195
hsa04727__26	0.420972891203552	DOWN	-0.807046981833694	0.455387485648517	GABAergic synapse: KCNJ6
hsa05032__81	0.420972891203552	DOWN	-0.807046981833694	0.455387485648517	Morphine addiction: KCNJ6
hsa05032__91	0.420972891203552	DOWN	-0.807046981833694	0.455387485648517	Morphine addiction: KCNJ6**
hsa05032__85	0.420972891203552	DOWN	-0.807046981833694	0.455387485648517	Morphine addiction: KCNJ6*
hsa04066__62	0.423647290740448	DOWN	-0.802422070763014	0.458016835041025	HIF-1 signaling pathway: NPPA
hsa04350__11	0.431729893917007	UP	0.788547337550973	0.466486757142068	TGF-beta signaling pathway: SMAD4*
hsa04014__42	0.442644496820407	UP	0.770047693268252	0.478005177888244	Ras signaling pathway: PLA2G4B
hsa05221__13	0.450932988433969	DOWN	-0.756172960056212	0.486676097224254	Acute myeloid leukemia: NFKB1
hsa04213__61	0.453715219555044	DOWN	-0.751548048985532	0.489116980805466	Longevity regulating pathway - multiple species: ATG5
hsa04530__20 31	0.453715219555044	UP	0.751548048985532	0.489116980805466	Tight junction: ACTB MLLT4
hsa04611__25	0.462119752096503	UP	0.737673315773491	0.49789163657645	Platelet activation: ORAI1
hsa05161__44	0.464940452984836	UP	0.733048404702811	0.500356879243131	Hepatitis B: CXCL8
hsa05164__65 66	0.464940452984836	UP	0.733048404702811	0.500356879243131	Influenza A: DNAJC3 HSPA1A
hsa04014__65	0.470610473100821	UP	0.72379858256145	0.505879335787438	Ras signaling pathway: MLLT4*
hsa05205__144	0.470610473100821	DOWN	-0.72379858256145	0.505879335787438	Proteoglycans in cancer: NUDT16L1
hsa04623__9	0.476318459040217	DOWN	-0.71454876042009	0.51172234679049	Cytosolic DNA-sensing pathway: IKBKE
hsa04072__3	0.484951102352292	DOWN	-0.700674027208049	0.520401554151889	Phospholipase D signaling pathway: MAPK1
hsa04261__23	0.484951102352292	DOWN	-0.700674027208049	0.520401554151889	Adrenergic signaling in cardiomyocytes: SLC9A1
hsa04261__72	0.487847370737521	UP	0.696049116137369	0.522018912081892	Adrenergic signaling in cardiomyocytes: ATP2B1
hsa04913__36	0.487847370737521	UP	0.696049116137369	0.522018912081892	Ovarian steroidogenesis: CYP19A1
hsa04913__37	0.487847370737521	UP	0.696049116137369	0.522018912081892	Ovarian steroidogenesis: CYP19A1*
hsa05160__53	0.487847370737521	UP	0.696049116137369	0.522018912081892	Hepatitis C: EIF2S1
hsa05162__74	0.487847370737521	UP	0.696049116137369	0.522018912081892	Measles: EIF2S1
hsa04066__51	0.493667797564418	UP	0.686799293996009	0.527946381117553	HIF-1 signaling pathway: TFRC
hsa04068__42	0.499525192376265	UP	0.677549471854648	0.533603090662309	FoxO signaling pathway: CDKN2D
hsa05142__36	0.499525192376265	UP	0.677549471854648	0.533603090662309	Chagas disease (American trypanosomiasis): SMAD2
hsa05110__52	0.511349799916361	DOWN	-0.659049827571928	0.545924019342524	Vibrio cholerae infection: ADCY3
hsa04976__38	0.51731644967781	UP	0.649800005430567	0.551980470723797	Bile secretion: ABCC2
hsa04725__43	0.52031323399264	UP	0.645175094359887	0.554548251090284	Cholinergic synapse: CREB3
hsa05205__81	0.52031323399264	UP	0.645175094359887	0.554548251090284	Proteoglycans in cancer: CTTN
hsa04390__60	0.523318941536973	UP	0.640550183289207	0.557435539199531	Hippo signaling pathway: CTGF*
hsa05213__12	0.52633353439851	UP	0.635925272218527	0.560329014807253	Endometrial cancer: BAD
hsa04024__116	0.53238922196131	DOWN	-0.626675450077166	0.566454896979219	cAMP signaling pathway: ACOX1
hsa05010__51	0.54460549818672	DOWN	-0.608175805794446	0.579124918558487	Alzheimer's disease: ATF6
hsa05152__90	0.553857738031221	DOWN	-0.594301072582405	0.588298235253064	Tuberculosis: CR1
hsa04520__1 13	0.553858210836972	UP	0.594301072582405	0.588298235253064	Adherens junction: SMAD4 SMAD2
hsa04724__44	0.563187234088604	DOWN	-0.580426339370364	0.597869385792365	Glutamatergic synapse: PRKACA*
hsa04919__104	0.566313663380416	DOWN	-0.575801428299684	0.600848883959233	Thyroid hormone signaling pathway: MYC
hsa04115__29	0.569448396003566	DOWN	-0.571176517229004	0.60383382397895	p53 signaling pathway: IGF1
hsa05152__15	0.578901959737592	DOWN	-0.557301784016963	0.613512003579772	Tuberculosis: CTSD
hsa04911__54	0.588428598840143	UP	0.543427050804923	0.623256672615912	Insulin secretion: RAB3A
hsa04920__3	0.591620163497592	DOWN	-0.538802139734243	0.626284105471536	Adipocytokine signaling pathway: C15493
hsa05161__68	0.594819656938096	DOWN	-0.534177228663562	0.629316517672682	Hepatitis B: JUN
hsa04390__88	0.601242234077227	DOWN	-0.524927406522202	0.63539603927509	Hippo signaling pathway: ID1
hsa04725__25	0.601242234077227	DOWN	-0.524927406522202	0.63539603927509	Cholinergic synapse: CACNA1A
hsa05231__48	0.617433951211061	DOWN	-0.501802851168801	0.652140750042486	Choline metabolism in cancer: WAS
hsa04270__65	0.623963259410717	UP	0.492553029027441	0.657928025691727	Vascular smooth muscle contraction: NPR2
hsa04924__58	0.623963673114772	DOWN	-0.492553029027441	0.657928025691727	Renin secretion: PPP3CA
hsa05031__59	0.623963673114772	DOWN	-0.492553029027441	0.657928025691727	Amphetamine addiction: PPP3CA
hsa05223__22	0.627239689563532	DOWN	-0.48792811795676	0.661011428317373	Non-small cell lung cancer: BAD*
hsa04728__71 72	0.633813766505075	DOWN	-0.4786782958154	0.66756506012502	Dopaminergic synapse: CLOCK ARNTL
hsa04727__47	0.637111718912925	UP	0.47405338474472	0.670662700189012	GABAergic synapse: CACNA1A*
hsa04750__62	0.653707261825209	UP	0.450928829391319	0.687746889680609	Inflammatory mediator regulation of TRP channels: TRPM8*
hsa04610__7	0.660395958673108	DOWN	-0.441679007249959	0.694006714959044	Complement and coagulation cascades: C00290
hsa05166__39	0.660395958673108	UP	0.441679007249959	0.694006714959044	HTLV-I infection: RRAS2
hsa05210__9 11	0.663749969621519	UP	0.437054096179278	0.697141527623719	Colorectal cancer: SMAD2 SMAD4
hsa04510__43	0.677232931824288	UP	0.418554451896558	0.710905407205496	Focal adhesion: BAD
hsa05030__73	0.680620106751828	UP	0.413929540825877	0.714062077379501	Cocaine addiction: NFKB1
hsa04015__18	0.704507639868868	UP	0.381555163331116	0.738298859628334	Rap1 signaling pathway: CDH1
hsa04931__61	0.704507639868868	DOWN	-0.381555163331116	0.738298859628334	Insulin resistance: ACACB
hsa04742__4	0.71483674380956	DOWN	-0.367680430119075	0.748705820299979	Taste transduction: TRPM5
hsa04213__62	0.718291529275338	DOWN	-0.363055519048395	0.751905171870953	Longevity regulating pathway - multiple species: CAT*
hsa05205__77	0.721752083521748	UP	0.358430607977715	0.755106996067574	Proteoglycans in cancer: MIR21
hsa04520__18	0.725218342038219	UP	0.353805696907035	0.758311221307631	Adherens junction: SNAI2
hsa04152__94	0.728690239963621	UP	0.349180785836355	0.761517775801804	AMPK signaling pathway: MLYCD
hsa04924__31	0.735650692865469	DOWN	-0.339930963694994	0.768364453526524	Renin secretion: C02135
hsa04151__26	0.742632916464367	DOWN	-0.330681141553634	0.774795807904801	PI3K-Akt signaling pathway: RBL2
hsa05231__34	0.742632916464367	UP	0.330681141553634	0.774795807904801	Choline metabolism in cancer: PLD1
hsa04213__71	0.746132026501175	DOWN	-0.326056230482954	0.77758296050788	Longevity regulating pathway - multiple species: SIRT1**
hsa04722__46	0.746132026501175	DOWN	-0.326056230482954	0.77758296050788	Neurotrophin signaling pathway: ATF4*
hsa05200__146 147	0.753145623772165	UP	0.316806408341593	0.783588387080785	Pathways in cancer: RARB RXRA
hsa05222__14 15	0.753145623772165	UP	0.316806408341593	0.783588387080785	Small cell lung cancer: RXRA RARB
hsa05223__29 34	0.753145623772165	UP	0.316806408341593	0.783588387080785	Non-small cell lung cancer: RARB RXRA
hsa05160__85	0.756660545944201	UP	0.312181497270913	0.786374538622319	Hepatitis C: BAD
hsa05168__29	0.756660545944201	UP	0.312181497270913	0.786374538622319	Herpes simplex infection: IKBKG
hsa04064__135	0.763704873903896	DOWN	-0.302931675129553	0.793256748515987	NF-kappa B signaling pathway: CCL19
hsa04014__64	0.76723442789735	DOWN	-0.298306764058873	0.796482591170785	Ras signaling pathway: PIK3R5*
hsa04015__100 101 48	0.777851823706713	UP	0.284432030846832	0.806613452949732	Rap1 signaling pathway: PRKCI PARD6A PARD3
hsa05220__4	0.777851823706713	UP	0.284432030846832	0.806613452949732	Chronic myeloid leukemia: PTPN11
hsa04068__44	0.784953337956633	UP	0.275182208705472	0.81352858357447	FoxO signaling pathway: CDKN1B
hsa04919__32	0.788510860324622	DOWN	-0.270557297634791	0.81676510835169	Thyroid hormone signaling pathway: PLN
hsa04919__102	0.792072798916206	UP	0.265932386564111	0.820002638657604	Thyroid hormone signaling pathway: BMP4
hsa04110__96 97	0.795639082930789	UP	0.261307475493431	0.823241099574313	Cell cycle: TFDP1 E2F4
hsa04530__11 13	0.799209641295395	DOWN	-0.256682564422751	0.82648041606717	Tight junction: TJP1 EPB41
hsa05150__35	0.802783941932334	UP	0.252057653352071	0.82972003679365	Staphylococcus aureus infection: FCAR
hsa03320__45	0.813533187499108	UP	0.23818292014003	0.840367707152734	PPAR signaling pathway: PDPK1
hsa04012__37 7	0.817124042283817	UP	0.23355800906935	0.84361322826994	ErbB signaling pathway: ERBB3 ERBB3
hsa04151__4	0.824317206287355	DOWN	-0.224308186927989	0.850105395507103	PI3K-Akt signaling pathway: RPS6
hsa05145__10	0.824317206287355	UP	0.224308186927989	0.850105395507103	Toxoplasmosis: MAPK8
hsa04068__58	0.831525155955122	DOWN	-0.215058364786629	0.856598557039296	FoxO signaling pathway: KLF2
hsa04970__18	0.831525155955122	UP	0.215058364786629	0.856598557039296	Salivary secretion: VAMP2
hsa04662__10	0.860493007279664	UP	0.178059076221187	0.885954170234788	B cell receptor signaling pathway: GSK3B
hsa04151__5	0.871406741367339	UP	0.164184343009147	0.896699489063105	PI3K-Akt signaling pathway: EIF4B
hsa05214__27	0.875050206963148	UP	0.159559431938467	0.899463533306212	Glioma: MTOR
hsa05214__48	0.875050206963148	UP	0.159559431938467	0.899463533306212	Glioma: MTOR*
hsa05223__9	0.882345014081697	DOWN	-0.150309609797106	0.906465982208588	Non-small cell lung cancer: BAD
hsa04064__97	0.885996203206398	UP	0.145684698726426	0.909222755775435	NF-kappa B signaling pathway: PLCG2
hsa05120__20	0.885996203206398	UP	0.145684698726426	0.909222755775435	Epithelial cell signaling in Helicobacter pylori infection: CXCL8
hsa04261__37	0.889649814174268	UP	0.141059787655746	0.912473799581578	Adrenergic signaling in cardiomyocytes: CREB3
hsa04062__40	0.893305770390845	DOWN	-0.136434876585066	0.915224396163794	Chemokine signaling pathway: PRKACA
hsa04390__12	0.893305770390845	UP	0.136434876585066	0.915224396163794	Hippo signaling pathway: CTGF
hsa04014__79	0.896963995112139	UP	0.131809965514386	0.918471578646163	Ras signaling pathway: RAC1**
hsa04062__60	0.907951510723122	DOWN	-0.117935232302345	0.929216170287988	Chemokine signaling pathway: GSK3A
hsa04115__9	0.911618039202311	DOWN	-0.113310321231665	0.932460694426316	p53 signaling pathway: RPRM
hsa04530__11 43	0.922628610637011	DOWN	-0.0994355880196242	0.942696660895565	Tight junction: TJP1 ACTN4
hsa05166__62 63	0.922628610637011	UP	0.0994355880196242	0.942696660895565	HTLV-I infection: ANAPC10 CDC20
hsa04726__71	0.926302204270701	UP	0.094810676948944	0.945935783600351	Serotonergic synapse: CACNA1A
hsa04931__46	0.937332104485042	DOWN	-0.0809359437369034	0.95616016521574	Insulin resistance: PIK3R5*
hsa05221__5	0.937332104485042	DOWN	-0.0809359437369034	0.95616016521574	Acute myeloid leukemia: SPI1
hsa04611__92	0.941011517443394	DOWN	-0.0763110326662232	0.959392643123244	Platelet activation: RHOA*
hsa05221__27	0.944692189845663	DOWN	-0.071686121595543	0.962622898438178	Acute myeloid leukemia: PIM2
hsa04740__13	0.948374043368126	UP	0.0670612105248628	0.965327642193234	Olfactory transduction: CNGA3
hsa04750__39	0.948374043368126	UP	0.0670612105248628	0.965327642193234	Inflammatory mediator regulation of TRP channels: C01245*
hsa04933__63	0.952056999611396	DOWN	-0.0624362994541826	0.968551760839097	AGE-RAGE signaling pathway in diabetic complications: SELE
hsa04750__53	0.955740980105421	UP	0.0578113883835024	0.971773431611518	Inflammatory mediator regulation of TRP channels: TRPM8
hsa04310__20	0.959425906314505	UP	0.0531864773128222	0.974992578672231	Wnt signaling pathway: MAPK8
hsa04910__39	0.966798281436982	UP	0.0439366551714618	0.981953497740589	Insulin signaling pathway: BAD
hsa04913__47	0.974173464779024	DOWN	-0.0346868330301015	0.988375777710468	Ovarian steroidogenesis: INSR
hsa04913__51	0.974173464779024	DOWN	-0.0346868330301015	0.988375777710468	Ovarian steroidogenesis: INSR*
hsa05145__67	0.98524026133899	DOWN	-0.0208120998180609	0.999064463602786	Toxoplasmosis: BAD
hsa04020__42	0.988929919766237	DOWN	-0.0161871887473807	1	Calcium signaling pathway: MYLK4
hsa04916__6	0.992619814963853	UP	0.0115622776767005	1	Melanogenesis: DCT
hsa05031__101	0.992619814963853	UP	0.0115622776767005	1	Amphetamine addiction: FOS*
hsa04213__13	0.996309868016822	UP	0.00693736660602029	1	Longevity regulating pathway - multiple species: RPS6KB1*
hsa05231__60	0.996309868016822	UP	0.00693736660602029	1	Choline metabolism in cancer: PRKCA
hsa04152__33	1	0	0	1	AMPK signaling pathway: CPT1C
hsa04152__41	1	0	0	1	AMPK signaling pathway: FBP1
hsa04211__2	1	0	0	1	Longevity regulating pathway - mammal: RPS6KB1
hsa04911__41	1	0	0	1	Insulin secretion: ABCC8
hsa04911__35	1	0	0	1	Insulin secretion: TRPM4
hsa04922__67	1	0	0	1	Glucagon signaling pathway: FBP1
hsa04922__60	1	0	0	1	Glucagon signaling pathway: CPT1C*
hsa04924__34	1	0	0	1	Renin secretion: REN
hsa04924__47	1	0	0	1	Renin secretion: KCNMA1
hsa04931__151	1	0	0	1	Insulin resistance: CPT1A
hsa04931__29	1	0	0	1	Insulin resistance: CPT1B
hsa04960__15	1	0	0	1	Aldosterone-regulated sodium reabsorption: C00762
hsa05030__13	1	0	0	1	Cocaine addiction: SLC6A3
hsa05031__15	1	0	0	1	Amphetamine addiction: MAOA
hsa05031__77	1	0	0	1	Amphetamine addiction: MAOA*
hsa05034__7	1	0	0	1	Alcoholism: GRIN3A
hsa05034__75	1	0	0	1	Alcoholism: SLC29A1
hsa05140__37	1	0	0	1	Leishmaniasis: ELK1
hsa05140__55	1	0	0	1	Leishmaniasis: JUN
hsa05140__41 57	1	0	0	1	Leishmaniasis: NOS2 CYBA
hsa05211__12	1	0	0	1	Renal cell carcinoma: EGLN2