p.value	UP.DOWN	statistic	FDRp.value	path.name
hsa04520__58	1.67524486076579e-43	UP	9.73337615184504	3.14778509337892e-40	Adherens junction: CDH1*
hsa04211__43 59 60 61	1.02098761546851e-35	UP	12.4753782552597	4.80426741532076e-33	Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101
hsa04750__8	1.02098761546851e-35	DOWN	-12.4753782552597	4.80426741532076e-33	Inflammatory mediator regulation of TRP channels: ASIC2
hsa04530__11 24 23	1.02272856100495e-35	DOWN	-12.4753782552597	4.80426741532076e-33	Tight junction: TJP1 YBX3 CDK4
hsa05120__20	6.83982299047133e-35	UP	12.3230926034541	2.57040547981913e-32	Epithelial cell signaling in Helicobacter pylori infection: CXCL8
hsa04014__45	9.80311087066055e-33	UP	11.9161371610584	3.07000755432853e-30	Ras signaling pathway: RAB5A
hsa04390__18	1.23003920282425e-32	UP	11.897209000947	3.30177666015252e-30	Hippo signaling pathway: MOB1A
hsa04742__31	3.84429820005664e-32	UP	11.8017078294757	9.02929539738302e-30	Taste transduction: C00076*
hsa04024__101	6.33919416968472e-32	UP	11.759549654682	1.32348287164862e-29	cAMP signaling pathway: HCN4
hsa04610__11	1.08672611440944e-31	UP	11.7139499962318	1.99298570359883e-29	Complement and coagulation cascades: F2R
hsa04922__17	1.16672925702965e-31	DOWN	-11.7079273998327	1.99298570359883e-29	Glucagon signaling pathway: PKM
hsa04350__44 45	2.16343372280731e-31	UP	11.6554447740692	3.38757663762912e-29	TGF-beta signaling pathway: TGFBR2 TGFBR1
hsa05200__194	2.70128535086175e-31	DOWN	-11.6365166139578	3.9043962878994e-29	Pathways in cancer: BCL2
hsa04340__49	4.16480884563124e-31	UP	11.5995206646491	5.58976844352936e-29	Hedgehog signaling pathway: CCND1
hsa04920__12	8.40233789308765e-31	DOWN	-11.5392947006582	1.05253286007411e-28	Adipocytokine signaling pathway: C00165
hsa05212__34	9.28619704199287e-31	UP	11.5306909915166	1.09054776511904e-28	Pancreatic cancer: E2F1
hsa04152__77	1.15676878055577e-30	UP	11.5117628314052	1.26929648740437e-28	AMPK signaling pathway: CCND1
hsa04014__27	1.21593064253745e-30	UP	11.5074609768344	1.26929648740437e-28	Ras signaling pathway: ABL1
hsa05200__129 130	1.35686816889277e-30	UP	11.4979968967787	1.27477764467476e-28	Pathways in cancer: CTBP1 HDAC1
hsa05220__12 13	1.35686816889277e-30	UP	11.4979968967787	1.27477764467476e-28	Chronic myeloid leukemia: HDAC1 CTBP1
hsa05162__101	1.62327640337852e-30	DOWN	-11.4825102203239	1.45244588664202e-28	Measles: CDKN1B
hsa04115__21	1.84738175147229e-30	UP	11.4713253984398	1.57783195955292e-28	p53 signaling pathway: DDB2
hsa04024__112	2.66755463800391e-30	DOWN	-11.4394916746161	2.17927615861276e-28	cAMP signaling pathway: GLI1
hsa05218__9	2.83104133637059e-30	UP	11.4343294491311	2.2164694462668e-28	Melanoma: CCND1
hsa04921__59	7.67494825549838e-30	UP	11.3474319868014	5.60145720440245e-28	Oxytocin signaling pathway: CCND1
hsa05200__168	7.75081890976389e-30	UP	11.3465716158872	5.60145720440245e-28	Pathways in cancer: E2F1
hsa05214__35	9.25105871766734e-30	UP	11.3310849394324	6.43805160388775e-28	Glioma: E2F1
hsa05215__13	1.02055823503274e-29	DOWN	-11.3224812302909	6.84867472723758e-28	Prostate cancer: BCL2
hsa04014__70	1.48116327413746e-29	UP	11.289787135553	9.59691652449751e-28	Ras signaling pathway: RIN1*
hsa05032__31	1.66567758914605e-29	UP	11.2794626845831	9.78065059376697e-28	Morphine addiction: GABRR3
hsa05032__33	1.66567758914605e-29	UP	11.2794626845831	9.78065059376697e-28	Morphine addiction: GABRR3*
hsa05032__55	1.66567758914605e-29	UP	11.2794626845831	9.78065059376697e-28	Morphine addiction: GABRR3**
hsa04211__50	2.12651470765639e-29	DOWN	-11.2579534117292	1.21082458657163e-27	Longevity regulating pathway - mammal: PPARGC1A*
hsa05032__30	2.8768359228088e-29	UP	11.2312819133904	1.58987491145816e-27	Morphine addiction: ADORA1
hsa04931__149	3.17105462819198e-29	DOWN	-11.2226782042488	1.70240332753506e-27	Insulin resistance: ACACB*
hsa04152__64	3.96568300266344e-29	DOWN	-11.2028896732232	2.06986621166794e-27	AMPK signaling pathway: ACACB
hsa05020__49	6.19498467913517e-29	UP	11.1633126111721	3.12313540114729e-27	Prion diseases: BAX
hsa04510__47	6.31608010875981e-29	UP	11.1615918693437	3.12313540114729e-27	Focal adhesion: CCND1
hsa04923__43	7.59021747813128e-29	UP	11.1452448219748	3.65692785677145e-27	Regulation of lipolysis in adipocytes: C00219
hsa05166__120	8.3600992129101e-29	UP	11.1366411128332	3.92715660526452e-27	HTLV-I infection: E2F1
hsa04340__50	9.1189670601526e-29	DOWN	-11.1288977746058	4.17915587951872e-27	Hedgehog signaling pathway: BCL2
hsa04151__35	9.94612752272536e-29	UP	11.1211544363784	4.44970800361927e-27	PI3K-Akt signaling pathway: CCND1
hsa04151__103	1.07436261547684e-28	DOWN	-11.1142714690652	4.67730852264962e-27	PI3K-Akt signaling pathway: BCL2*
hsa05217__3	1.0952718200989e-28	DOWN	-11.1125507272369	4.67730852264962e-27	Basal cell carcinoma: GLI1
hsa04115__54	1.13830891821513e-28	UP	11.1091092435802	4.75307212739164e-27	p53 signaling pathway: PERP
hsa04071__65	1.40678957300403e-28	UP	11.0901810834688	5.74642958190124e-27	Sphingolipid signaling pathway: BAX*
hsa04972__21	1.60943886494083e-28	DOWN	-11.0781358906706	6.43433112175282e-27	Pancreatic secretion: KCNQ1
hsa04261__3	2.16703879443265e-28	DOWN	-11.0514643923318	8.22215857973995e-27	Adrenergic signaling in cardiomyocytes: RYR2
hsa04917__71	2.16703879443265e-28	UP	11.0514643923318	8.22215857973995e-27	Prolactin signaling pathway: CCND1*
hsa04510__20 4 5	2.18790808401808e-28	UP	11.0506040214176	8.22215857973995e-27	Focal adhesion: VASP ITGB1 ITGA11
hsa04390__90	2.36220010464581e-28	UP	11.0437210541044	8.70308626790094e-27	Hippo signaling pathway: BBC3
hsa04115__39	2.57478426476569e-28	UP	11.035977715877	9.30388391056681e-27	p53 signaling pathway: BAX
hsa05205__337	3.08789530070853e-28	DOWN	-11.019630668508	1.0947462773644e-26	Proteoglycans in cancer: CTNNB1**
hsa04115__34	3.77361747807007e-28	UP	11.0015628793108	1.31307911875809e-26	p53 signaling pathway: ZMAT3
hsa05131__38	3.99591658327713e-28	UP	10.9964006538258	1.36515041090504e-26	Shigellosis: CXCL8
hsa04152__68	4.4377269809351e-28	DOWN	-10.9869365737701	1.48901589235304e-26	AMPK signaling pathway: PPARGC1A**
hsa04210__60	6.68077091442427e-28	UP	10.9499406244614	2.2023102716146e-26	Apoptosis: BBC3
hsa05200__223	7.0724567748575e-28	UP	10.9447783989765	2.25239767456902e-26	Pathways in cancer: CCND1****
hsa05221__17	7.0724567748575e-28	UP	10.9447783989765	2.25239767456902e-26	Acute myeloid leukemia: CCND1
hsa04211__42	7.20801460170238e-28	DOWN	-10.9430576571482	2.2573099060998e-26	Longevity regulating pathway - mammal: PPARGC1A
hsa04210__74	1.01394389401173e-27	UP	10.9120843042385	3.1232796341771e-26	Apoptosis: BAX*
hsa04066__88	1.14664344215635e-27	DOWN	-10.9008994823545	3.47506939969641e-26	HIF-1 signaling pathway: BCL2
hsa05211__22	1.5222530598288e-27	UP	10.8750883549298	4.51157296514056e-26	Renal cell carcinoma: TGFA
hsa05205__144	1.53667200515698e-27	UP	10.8742279840157	4.51157296514056e-26	Proteoglycans in cancer: NUDT16L1
hsa04014__61	1.96333354013109e-27	UP	10.8518583402476	5.67554418754818e-26	Ras signaling pathway: RAP1A
hsa04022__9	2.15706730455157e-27	UP	10.8432546311061	6.14110525038241e-26	cGMP-PKG signaling pathway: ITPR1
hsa04922__78	2.28228647268942e-27	DOWN	-10.8380924056211	6.40062131669167e-26	Glucagon signaling pathway: ACACA
hsa04910__48	2.36974392551238e-27	DOWN	-10.8346509219645	6.5481600529967e-26	Insulin signaling pathway: PPARGC1A
hsa05016__22 9	2.60319831167276e-27	UP	10.826047212823	7.08899946033784e-26	Huntington's disease: DLG4 HTT
hsa03320__30	2.67758204133365e-27	UP	10.8234661000805	7.1873952223799e-26	PPAR signaling pathway: LPL
hsa04115__49	2.88640217610488e-27	UP	10.8165831327672	7.63880237873391e-26	p53 signaling pathway: MDM2*
hsa04932__7	2.96880623396572e-27	UP	10.8140020200248	7.7477596022522e-26	Non-alcoholic fatty liver disease (NAFLD): SREBF1
hsa04630__28	3.44931962671569e-27	UP	10.8002360853983	8.87845421725861e-26	Jak-STAT signaling pathway: CCND1
hsa04014__67	3.82364711806272e-27	UP	10.7907720053426	9.70896342545927e-26	Ras signaling pathway: RAPGEF5*
hsa05223__28	5.20570333661257e-27	UP	10.7623797651754	1.304202209266e-25	Non-small cell lung cancer: RB1
hsa05211__49	5.98789883547187e-27	UP	10.7494742014631	1.48042919892785e-25	Renal cell carcinoma: TGFA*
hsa04924__52	6.82262919024362e-27	UP	10.7374290086649	1.66489873356724e-25	Renin secretion: KCNJ2
hsa04960__3	8.14274860734813e-27	DOWN	-10.7210819612959	1.96156726066758e-25	Aldosterone-regulated sodium reabsorption: SCNN1A
hsa05223__37	1.03682535397512e-26	UP	10.6987123175279	2.46606941787247e-25	Non-small cell lung cancer: CCND1*
hsa05200__203	1.66307888697419e-26	UP	10.6548334009059	3.90615653578063e-25	Pathways in cancer: TGFA*
hsa04919__43	1.75792508982052e-26	DOWN	-10.649671175421	4.07795215280587e-25	Thyroid hormone signaling pathway: TBC1D4
hsa04727__17 37	1.85813131592481e-26	UP	10.6445089499361	4.25783993002771e-25	GABAergic synapse: GABRA1 GPHN
hsa04725__50	2.0567712820103e-26	DOWN	-10.6350448698804	4.65623281794861e-25	Cholinergic synapse: BCL2
hsa04115__18	2.25554845646409e-26	UP	10.6264411607388	5.04544708297146e-25	p53 signaling pathway: CCNG1
hsa04621__44	2.31881336035338e-26	UP	10.6238600479963	5.12594153424e-25	NOD-like receptor signaling pathway: MAPK14
hsa05205__304	2.36196407823363e-26	DOWN	-10.622139306168	5.16061686395463e-25	Proteoglycans in cancer: MAPK1*****
hsa04540__1	2.81362086410221e-26	DOWN	-10.6057922587991	6.07677425706672e-25	Gap junction: C00681
hsa05161__97	3.11338404291081e-26	DOWN	-10.5963281787434	6.64778251889705e-25	Hepatitis B: BCL2
hsa04152__57	3.63984044791208e-26	UP	10.5817018732027	7.68456202429977e-25	AMPK signaling pathway: ACACA*
hsa04152__58	4.49502703512519e-26	UP	10.5619133421771	9.3846175544447e-25	AMPK signaling pathway: SCD
hsa04920__40	5.59999035509859e-26	DOWN	-10.5412644402374	1.15630570079453e-24	Adipocytokine signaling pathway: PPARGC1A
hsa04931__61	7.64013239845915e-26	DOWN	-10.5120118291561	1.54121164134372e-24	Insulin resistance: ACACB
hsa04913__21	7.71015935531184e-26	DOWN	-10.5111514582419	1.54121164134372e-24	Ovarian steroidogenesis: CYP17A1
hsa04913__22	7.71015935531184e-26	DOWN	-10.5111514582419	1.54121164134372e-24	Ovarian steroidogenesis: CYP17A1*
hsa04115__55	7.92407998492552e-26	UP	10.5085703454995	1.56729960965001e-24	p53 signaling pathway: SHISA5
hsa04913__47	8.60177600437503e-26	UP	10.5008270072721	1.66626155796089e-24	Ovarian steroidogenesis: INSR
hsa04913__51	8.60177600437503e-26	UP	10.5008270072721	1.66626155796089e-24	Ovarian steroidogenesis: INSR*
hsa05218__21	8.92112288835236e-26	UP	10.4973855236154	1.6932111017388e-24	Melanoma: RB1
hsa05220__40	8.92112288835236e-26	UP	10.4973855236154	1.6932111017388e-24	Chronic myeloid leukemia: RB1
hsa04530__20 62	9.68325816917358e-26	UP	10.489642185388	1.81948420998772e-24	Tight junction: ACTB SHROOM1
hsa04360__31	1.07028637136484e-25	DOWN	-10.4801781053323	1.99115652652925e-24	Axon guidance: CDC42*
hsa05200__191	1.51147750209922e-25	UP	10.4474840105944	2.7843786533769e-24	Pathways in cancer: CCND1*
hsa03320__58	1.55316083887443e-25	DOWN	-10.4449028978519	2.83338758858744e-24	PPAR signaling pathway: CYP8B1
hsa04340__52	1.61051570034892e-25	DOWN	-10.4414614141953	2.90976827014964e-24	Hedgehog signaling pathway: BCL2*
hsa04024__114	2.46392945770144e-25	DOWN	-10.40102398123	4.40926042954381e-24	cAMP signaling pathway: HHIP
hsa04014__63	2.53157844490839e-25	UP	10.3984428684875	4.4875810358329e-24	Ras signaling pathway: TIAM1*
hsa04621__42	3.00486209794156e-25	UP	10.3820958211185	5.27676250657215e-24	NOD-like receptor signaling pathway: MAPK8
hsa04210__75	3.22946370107192e-25	UP	10.3752128538053	5.61749233394075e-24	Apoptosis: BAK1*
hsa04350__32	3.25868368493636e-25	UP	10.3743524828911	5.61749233394075e-24	TGF-beta signaling pathway: RPS6KB1
hsa04211__38	3.66325029839696e-25	UP	10.3631676610071	6.25749755517082e-24	Longevity regulating pathway - mammal: BAX
hsa04151__96	4.08069011813629e-25	DOWN	-10.3528432100372	6.90776282160189e-24	PI3K-Akt signaling pathway: BCL2
hsa04922__59	4.58621537133834e-25	DOWN	-10.3416583881532	7.69419525245067e-24	Glucagon signaling pathway: CPT1C
hsa05219__21	6.05601316160819e-25	UP	10.3149868898144	1.00701316200547e-23	Bladder cancer: RB1
hsa04931__135	6.56418466547651e-25	UP	10.307243551587	1.0819388584588e-23	Insulin resistance: SREBF1**
hsa03320__53	7.05121702051298e-25	DOWN	-10.3003605842737	1.15210754622121e-23	PPAR signaling pathway: ADIPOQ
hsa05217__5	1.01683580007738e-24	DOWN	-10.2650853767934	1.6470986796081e-23	Basal cell carcinoma: BMP2
hsa05205__145	1.05351840024443e-24	UP	10.2616438931367	1.69193254193101e-23	Proteoglycans in cancer: PXN
hsa04340__13	1.10173842768995e-24	DOWN	-10.2573420385659	1.7543783946012e-23	Hedgehog signaling pathway: GLI1*
hsa05164__78	1.2591204209477e-24	UP	10.2444364748536	1.98814056383255e-23	Influenza A: GSK3B
hsa05205__120	1.28172155399971e-24	UP	10.2427157330253	2.00696233330454e-23	Proteoglycans in cancer: PLAU
hsa04151__28	1.30472454762033e-24	DOWN	-10.240994991197	2.02609704543686e-23	PI3K-Akt signaling pathway: BCL2L11
hsa04068__49	1.31637894859402e-24	DOWN	-10.2401346202828	2.02743938066243e-23	FoxO signaling pathway: BCL2L11
hsa04360__20	1.5723742690763e-24	UP	10.2229272019997	2.4020254078003e-23	Axon guidance: ROCK1
hsa04510__19 23	1.61480909761325e-24	UP	10.2203460892572	2.44695668904459e-23	Focal adhesion: VCL TLN1
hsa04510__19 26	1.64372729721183e-24	UP	10.2186253474289	2.47085087316883e-23	Focal adhesion: VCL ACTN4
hsa04115__20	1.89431646566618e-24	UP	10.2048594128024	2.82493701506885e-23	p53 signaling pathway: RRM2B
hsa04064__134	2.1443988106227e-24	DOWN	-10.1928142200043	3.1726971379213e-23	NF-kappa B signaling pathway: CCL21
hsa05020__48	2.20210167947653e-24	DOWN	-10.1902331072618	3.23261644979406e-23	Prion diseases: SOD1
hsa04310__35	2.24142209663019e-24	DOWN	-10.1885123654335	3.26483110044041e-23	Wnt signaling pathway: JUN
hsa04211__62	2.89621991525045e-24	DOWN	-10.163561608923	4.18615170827353e-23	Longevity regulating pathway - mammal: EHMT2
hsa04115__36	2.97393077117965e-24	UP	10.1609804961805	4.26566100690578e-23	p53 signaling pathway: EI24
hsa05134__71	3.05370659308308e-24	UP	10.158399383438	4.34690506697206e-23	Legionellosis: CXCL8
hsa05221__13	3.39456748984419e-24	DOWN	-10.1480749324682	4.79578369429867e-23	Acute myeloid leukemia: NFKB1
hsa05161__125	3.45493206107547e-24	UP	10.1463541906398	4.84463980803045e-23	Hepatitis B: CDKN1A
hsa05216__15	3.8064452672922e-24	UP	10.1368901105841	5.29800789425337e-23	Thyroid cancer: CCND1
hsa05217__19	6.39093047947309e-24	DOWN	-10.0861282266489	8.82982233156613e-23	Basal cell carcinoma: HHIP
hsa05200__212	6.56111142773315e-24	UP	10.0835471139065	8.99877983409532e-23	Pathways in cancer: CCND1***
hsa04621__43	8.02387780932118e-24	UP	10.0637585828809	1.0925265509938e-22	NOD-like receptor signaling pathway: MAPK1
hsa05200__121 122	8.38230600313463e-24	UP	10.0594567283101	1.12502521284928e-22	Pathways in cancer: SMAD2 SMAD4
hsa05212__38 39	8.38230600313463e-24	UP	10.0594567283101	1.12502521284928e-22	Pancreatic cancer: SMAD2 SMAD4
hsa04213__54	8.45587192800692e-24	DOWN	-10.0585963573959	1.12684988317199e-22	Longevity regulating pathway - multiple species: SOD2*
hsa04520__34	8.91066893375088e-24	DOWN	-10.053434131911	1.17909485398013e-22	Adherens junction: RHOA
hsa04068__60	1.0702861896753e-23	DOWN	-10.0353663427137	1.40634108419573e-22	FoxO signaling pathway: RAG1
hsa04014__76	1.17795325692099e-23	UP	10.025902262658	1.53706539566287e-22	Ras signaling pathway: RALBP1*
hsa05321__95	1.78783392546705e-23	UP	9.98460445877855	2.31678616962248e-22	Inflammatory bowel disease (IBD): SMAD2
hsa05205__69	1.81911944060704e-23	UP	9.98288371695024	2.34118180061686e-22	Proteoglycans in cancer: MAPK1*
hsa04024__113	2.44199648174848e-23	DOWN	-9.95363110586894	3.12143631918735e-22	cAMP signaling pathway: PTCH1
hsa05217__4	2.48459809701387e-23	DOWN	-9.95191036404063	3.15443231370883e-22	Basal cell carcinoma: PTCH1
hsa04152__27	2.57202127100021e-23	DOWN	-9.948468880384	3.24350870349623e-22	AMPK signaling pathway: ADIPOR1
hsa04630__30	3.24724870974378e-23	UP	9.92523886570179	4.06772021707238e-22	Jak-STAT signaling pathway: CDKN1A
hsa04068__41	3.30373840764059e-23	UP	9.92351812387348	4.11107580659381e-22	FoxO signaling pathway: CDKN2B
hsa04151__2	3.92497232084709e-23	DOWN	-9.90631070559037	4.851988809784e-22	PI3K-Akt signaling pathway: EIF4E
hsa04810__82 83	4.6616556383912e-23	UP	9.88910328730725	5.72500061734449e-22	Regulation of actin cytoskeleton: ACTB ARPC5
hsa05200__146 147	5.44067419780322e-23	DOWN	-9.87361661085244	6.55322231902067e-22	Pathways in cancer: RARB RXRA
hsa05222__14 15	5.44067419780322e-23	DOWN	-9.87361661085244	6.55322231902067e-22	Small cell lung cancer: RXRA RARB
hsa05223__29 34	5.44067419780322e-23	DOWN	-9.87361661085244	6.55322231902067e-22	Non-small cell lung cancer: RARB RXRA
hsa05200__204	5.58266921505192e-23	UP	9.87103549810998	6.68142385674048e-22	Pathways in cancer: TGFB1*
hsa04151__32	5.67926166368825e-23	UP	9.86931475628166	6.75400801650014e-22	PI3K-Akt signaling pathway: BCL2L1
hsa04630__34	5.77750843271513e-23	DOWN	-9.86759401445335	6.82763417929039e-22	Jak-STAT signaling pathway: AOX1
hsa04210__58	6.85737093030059e-23	UP	9.85038659617024	8.05312498627176e-22	Apoptosis: BID*
hsa05168__39 40	7.72989884492126e-23	UP	9.83834140337205	9.02141610534599e-22	Herpes simplex infection: POU2F3 HCFC2
hsa04350__34	7.79626986529703e-23	UP	9.8374810324579	9.04271054129204e-22	TGF-beta signaling pathway: ROCK1
hsa04390__88	9.48853620118062e-23	DOWN	-9.81769250143231	1.09380119766984e-21	Hippo signaling pathway: ID1
hsa04350__27	1.12524473716478e-22	UP	9.8004850831492	1.28922857386135e-21	TGF-beta signaling pathway: ACVR2A*
hsa05100__24	1.246276868295e-22	UP	9.79016063217933	1.41924499122806e-21	Bacterial invasion of epithelial cells: ACTB
hsa04115__22	1.32273983646073e-22	UP	9.78413803578024	1.49724587512633e-21	p53 signaling pathway: STEAP3
hsa05100__33	1.41582476458228e-22	UP	9.77725506846699	1.59301480997013e-21	Bacterial invasion of epithelial cells: DNM1
hsa04740__33	1.42790710941039e-22	UP	9.77639469755283	1.59704610629888e-21	Olfactory transduction: CNGA3*
hsa05205__81	1.48986678689848e-22	UP	9.77209284298205	1.6564850251966e-21	Proteoglycans in cancer: CTTN
hsa04520__17	1.60817332529624e-22	DOWN	-9.76434950475465	1.77750451660684e-21	Adherens junction: SNAI1
hsa05221__29	1.67786902053663e-22	DOWN	-9.76004765018387	1.84369350268323e-21	Acute myeloid leukemia: RPS6KB1
hsa04520__4	1.75055314170602e-22	DOWN	-9.75574579561309	1.91237753096838e-21	Adherens junction: CTNND1
hsa04922__50	1.78049176197947e-22	DOWN	-9.75402505378478	1.93384047442741e-21	Glucagon signaling pathway: PCK1
hsa04213__62	1.79565056231494e-22	DOWN	-9.75316468287063	1.93909621068377e-21	Longevity regulating pathway - multiple species: CAT*
hsa04713__61	1.85757377824249e-22	DOWN	-9.749723199214	1.99450350246723e-21	Circadian entrainment: FOS
hsa04210__99	2.00473515018815e-22	UP	9.7419798609866	2.14028258363837e-21	Apoptosis: BID**
hsa05210__23	2.02178237532575e-22	UP	9.74111949007244	2.14628761764807e-21	Colorectal cancer: CCND1
hsa05220__19 41	2.09141793461689e-22	UP	9.73767800641582	2.20773837030626e-21	Chronic myeloid leukemia: SMAD4 SMAD3
hsa04621__28	2.21903836931345e-22	UP	9.73165541001673	2.3293704446592e-21	NOD-like receptor signaling pathway: CASP8
hsa04115__1	2.35436178287908e-22	UP	9.72563281361764	2.45769210557211e-21	p53 signaling pathway: SIAH1
hsa04340__15	2.58369107424184e-22	DOWN	-9.71616873356192	2.6821853748621e-21	Hedgehog signaling pathway: HHIP
hsa04071__57	2.83510703092407e-22	UP	9.70670465350621	2.92701434676171e-21	Sphingolipid signaling pathway: BAX
hsa04930__3	3.03302060567063e-22	DOWN	-9.69982168619296	3.114232632817e-21	Type II diabetes mellitus: SLC2A4
hsa05211__2	3.16359737001963e-22	UP	9.69551983162218	3.23065187949287e-21	Renal cell carcinoma: TGFB1
hsa04976__95 96	3.21621737932931e-22	UP	9.69379908979387	3.26663375987015e-21	Bile secretion: SLC51A SLC51B
hsa04722__73 77	3.9377064934697e-22	DOWN	-9.67315018785413	3.97793037700515e-21	Neurotrophin signaling pathway: NGFRAP1 YWHAE
hsa03320__59	4.10676504936711e-22	DOWN	-9.66884833328335	4.12653022874909e-21	PPAR signaling pathway: NR1H3
hsa04115__37	5.06597560515768e-22	UP	9.64733906042946	5.06328093728259e-21	p53 signaling pathway: FAS
hsa04015__3	5.2828937215722e-22	UP	9.64303720585868	5.25214672107628e-21	Rap1 signaling pathway: MAPK1
hsa03320__40	5.55535616930481e-22	DOWN	-9.63787498037374	5.49395486427565e-21	PPAR signaling pathway: FABP4
hsa05223__14	5.74467635368439e-22	UP	9.63443349671712	5.65143815108533e-21	Non-small cell lung cancer: CCND1
hsa04211__29	7.63424498391875e-22	DOWN	-9.60518088563582	7.47122204415798e-21	Longevity regulating pathway - mammal: EIF4E
hsa03320__8	8.02642436760167e-22	DOWN	-9.60001866015089	7.81432714338007e-21	PPAR signaling pathway: GK
hsa05214__52	1.05675788650412e-21	UP	9.57162641998374	1.02352993234084e-20	Glioma: E2F1*
hsa04014__54	1.06558939046772e-21	UP	9.57076604906959	1.02679100753275e-20	Ras signaling pathway: RHOA
hsa04310__16	1.09252441039298e-21	UP	9.56818493632712	1.04737416690225e-20	Wnt signaling pathway: CAMK2A
hsa04024__123	1.11085421172456e-21	UP	9.56646419449881	1.0595406415383e-20	cAMP signaling pathway: PAK1
hsa05161__213	1.18726593088875e-21	UP	9.55958122718556	1.12670337582827e-20	Hepatitis B: E2F1
hsa04350__21	1.21724180175995e-21	UP	9.55700011444309	1.14934539975224e-20	TGF-beta signaling pathway: CDKN2B
hsa04630__36	1.31173538589602e-21	UP	9.54925677621569	1.23237539504931e-20	Jak-STAT signaling pathway: GFAP
hsa05205__146	1.4371299129122e-21	UP	9.53979269615998	1.34346622207066e-20	Proteoglycans in cancer: PTK2
hsa04340__33	1.44910096890772e-21	DOWN	-9.53893232524582	1.34795085177109e-20	Hedgehog signaling pathway: HHIP*
hsa04014__66	1.5613774032191e-21	UP	9.53118898701842	1.44523553726537e-20	Ras signaling pathway: RAF1*
hsa05160__12 13 14	1.73890455261673e-21	DOWN	-9.52000416513439	1.60166747763081e-20	Hepatitis C: IKBKG CHUK IKBKB
hsa04740__13	2.05173516212032e-21	UP	9.50279674685128	1.88059042420687e-20	Olfactory transduction: CNGA3
hsa04152__54	2.15600693483147e-21	DOWN	-9.49763452136634	1.96657137405258e-20	AMPK signaling pathway: SLC2A4*
hsa04014__69	2.19191592710559e-21	UP	9.49591377953803	1.98966667972532e-20	Ras signaling pathway: PLCE1*
hsa04380__68	2.58518301123919e-21	UP	9.47870636125491	2.33536484524925e-20	Osteoclast differentiation: TGFBR1
hsa04014__97	3.30943461093986e-21	UP	9.45289523383024	2.9753242267732e-20	Ras signaling pathway: PAK4
hsa04072__57	3.56349972703411e-21	UP	9.44515189560283	3.18848380337957e-20	Phospholipase D signaling pathway: C06124
hsa04630__31	3.99755558242756e-21	UP	9.43310670280465	3.55990850207648e-20	Jak-STAT signaling pathway: BCL2L1
hsa04261__37	4.06368965177099e-21	DOWN	-9.43138596097634	3.60173247909325e-20	Adrenergic signaling in cardiomyocytes: CREB3
hsa04150__31	4.41094414189597e-21	DOWN	-9.42278225183478	3.89115682752231e-20	mTOR signaling pathway: EIF4E
hsa04310__36	5.1535307773486e-21	DOWN	-9.40643520446582	4.52499267786823e-20	Wnt signaling pathway: MYC
hsa04115__56	5.41277482113948e-21	UP	9.40127297898089	4.73051343670748e-20	p53 signaling pathway: SESN3
hsa04921__80	6.11867773581565e-21	UP	9.38836741526855	5.32268308592482e-20	Oxytocin signaling pathway: KCNJ2
hsa03320__10	6.63910548159794e-21	DOWN	-9.37976370612699	5.74879225802882e-20	PPAR signaling pathway: PLIN1
hsa05205__77	8.13942550475971e-21	DOWN	-9.35825443327309	6.9836595267557e-20	Proteoglycans in cancer: MIR21
hsa05160__70	8.13954995401543e-21	UP	9.35825443327309	6.9836595267557e-20	Hepatitis C: CDKN1A
hsa04261__62	8.61672440308604e-21	DOWN	-9.352231836874	7.35946597881758e-20	Adrenergic signaling in cardiomyocytes: BCL2
hsa04360__18	9.734370927597e-21	UP	9.33932627316167	8.23913647430395e-20	Axon guidance: PTK2
hsa04713__60	9.734370927597e-21	DOWN	-9.33932627316167	8.23913647430395e-20	Circadian entrainment: PER1
hsa04919__44	1.21189727753472e-20	DOWN	-9.31609625847946	1.02114573295414e-19	Thyroid hormone signaling pathway: PFKFB2
hsa04022__45	1.26200828332083e-20	DOWN	-9.31179440390868	1.05862212694636e-19	cGMP-PKG signaling pathway: CREB3
hsa05205__103	1.29305270372379e-20	UP	9.30921329116621	1.079842680132e-19	Proteoglycans in cancer: CCND1
hsa04922__51	1.36845697063927e-20	DOWN	-9.30319069476712	1.13775692381911e-19	Glucagon signaling pathway: G6PC
hsa05200__184	1.62174442129258e-20	DOWN	-9.28512290556985	1.34240430291135e-19	Pathways in cancer: GLI1
hsa04510__20 69	1.66152492307191e-20	UP	9.28254179282738	1.36930058353163e-19	Focal adhesion: VASP ACTB
hsa04724__13	1.92124333649538e-20	UP	9.26705511637257	1.57642630099337e-19	Glutamatergic synapse: GRM5
hsa04024__3	1.96832976796598e-20	DOWN	-9.26447400363011	1.60803984087307e-19	cAMP signaling pathway: RYR2
hsa05200__66	2.00031878654965e-20	UP	9.2627532618018	1.62709913416745e-19	Pathways in cancer: CCND1
hsa05200__53	2.06584676540579e-20	UP	9.25931177814517	1.67315778974029e-19	Pathways in cancer: BCL2L1
hsa05211__21	2.15074817755637e-20	UP	9.25500992357439	1.73444456035554e-19	Renal cell carcinoma: TGFB1*
hsa04390__89	2.62982968033249e-20	DOWN	-9.2335006507205	2.11173075613023e-19	Hippo signaling pathway: ID2
hsa05215__14	2.89587162000379e-20	UP	9.22317619975063	2.31546501020729e-19	Prostate cancer: CCND1
hsa04920__2	3.42696430904181e-20	DOWN	-9.20510841055335	2.72850251554642e-19	Adipocytokine signaling pathway: C00638
hsa04360__40 142	4.18587855545125e-20	UP	9.18359913769946	3.31867755514468e-19	Axon guidance: UNC5D PTPN11
hsa05205__121	4.21946678721468e-20	UP	9.1827387667853	3.33125129965395e-19	Proteoglycans in cancer: PLAUR
hsa04014__43	5.57879619071936e-20	UP	9.15262578478985	4.38600754910531e-19	Ras signaling pathway: ELK1
hsa04115__2	6.04117243471839e-20	UP	9.14402207564829	4.72973458534828e-19	p53 signaling pathway: IGFBP3
hsa04110__59 15 16 17 18 19 20	7.19593044139133e-20	UP	9.12509391553686	5.61043705368228e-19	Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
hsa04152__35	7.42817927981662e-20	DOWN	-9.12165243188024	5.76758217635349e-19	AMPK signaling pathway: PFKFB1
hsa05016__48	8.04171498582258e-20	UP	9.11304872273868	6.19277969604943e-19	Huntington's disease: HIP1
hsa05016__46	8.04171498582258e-20	UP	9.11304872273868	6.19277969604943e-19	Huntington's disease: HTT**
hsa04115__19	8.17030223797228e-20	UP	9.11132798091037	6.26612159393874e-19	p53 signaling pathway: RFWD2
hsa03320__22	9.20170777500039e-20	DOWN	-9.09842241719803	7.02845890618932e-19	PPAR signaling pathway: ACADM
hsa03460__7	1.01186178968191e-19	UP	9.08809796622816	7.66648509198512e-19	Fanconi anemia pathway: FANCI
hsa04014__103	1.01186178968191e-19	DOWN	-9.08809796622816	7.66648509198512e-19	Ras signaling pathway: KSR2
hsa04024__77	1.06945907225559e-19	DOWN	-9.08207536982907	8.07033572999302e-19	cAMP signaling pathway: RHOA*
hsa05160__15 16	1.10381430486279e-19	DOWN	-9.07863388617245	8.29626831534874e-19	Hepatitis C: TRAF6 RIPK1
hsa05031__11	1.13925982231674e-19	DOWN	-9.07519240251582	8.49471907195698e-19	Amphetamine addiction: GRIN3A
hsa05031__54	1.13925982231674e-19	DOWN	-9.07519240251582	8.49471907195698e-19	Amphetamine addiction: GRIN3A*
hsa04550__60	1.36600719067778e-19	UP	9.05540387149024	1.01451680287887e-18	Signaling pathways regulating pluripotency of stem cells: MAPK14
hsa04115__15	1.52529649251517e-19	UP	9.04335867869206	1.12393416056314e-18	p53 signaling pathway: TSC2
hsa04921__33	1.52529649251517e-19	UP	9.04335867869206	1.12393416056314e-18	Oxytocin signaling pathway: C00942
hsa04152__56	2.05616543757374e-19	UP	9.01066458395413	1.50919330359416e-18	AMPK signaling pathway: FASN
hsa05215__12	2.07235959009021e-19	DOWN	-9.00980421303998	1.5151609610037e-18	Prostate cancer: KLK3
hsa05169__79	2.17220497649787e-19	DOWN	-9.00464198755504	1.58200509722461e-18	Epstein-Barr virus infection: ATF2
hsa05200__211	2.44309287251289e-19	UP	8.99173642384271	1.77242143144854e-18	Pathways in cancer: CXCL8
hsa04610__57	2.5207997506209e-19	UP	8.98829494018608	1.82176258900641e-18	Complement and coagulation cascades: PLAUR
hsa04115__64	2.74730989388328e-19	UP	8.97883086013037	1.97785260176502e-18	p53 signaling pathway: PMAIP1
hsa05200__195	2.92456430511935e-19	DOWN	-8.97194789281712	2.09742607989285e-18	Pathways in cancer: BIRC8
hsa05152__120	2.94750082776993e-19	UP	8.97108752190297	2.10583804387061e-18	Tuberculosis: TGFB1
hsa04024__76	3.21183577764904e-19	UP	8.96162344184725	2.28599978265248e-18	cAMP signaling pathway: C00416
hsa04920__3	3.23699686796234e-19	DOWN	-8.9607630709331	2.29521400562311e-18	Adipocytokine signaling pathway: C15493
hsa04012__21	3.41866082879382e-19	UP	8.954740474534	2.41491116439984e-18	ErbB signaling pathway: GSK3B
hsa05205__352	3.58235373907339e-19	UP	8.94957824904907	2.52106467255389e-18	Proteoglycans in cancer: ITGA5*
hsa05200__188	3.78315822927237e-19	DOWN	-8.94355565264998	2.65244563910552e-18	Pathways in cancer: KLK3
hsa04550__69	4.12137427848811e-19	DOWN	-8.93409157259426	2.87883355735284e-18	Signaling pathways regulating pluripotency of stem cells: ID1
hsa04340__32	4.31827176439429e-19	DOWN	-8.92892934710933	3.00519727603588e-18	Hedgehog signaling pathway: PTCH1***
hsa04916__6	4.48942955901221e-19	DOWN	-8.92462749253855	3.11278160198669e-18	Melanogenesis: DCT
hsa04152__82	4.59532322062818e-19	DOWN	-8.92204637979608	3.17448982777954e-18	AMPK signaling pathway: HMGCR
hsa04919__27	5.16294718209144e-19	DOWN	-8.90914081608375	3.55354496525634e-18	Thyroid hormone signaling pathway: GATA4
hsa05221__35	5.24368381802381e-19	UP	8.90742007425543	3.59594229710465e-18	Acute myeloid leukemia: EIF4EBP1
hsa05110__50	6.82318200116461e-19	DOWN	-8.87816746317413	4.66209417461393e-18	Vibrio cholerae infection: ACTB
hsa04520__9 57	9.73076678766649e-19	DOWN	-8.83859040112297	6.62467782392222e-18	Adherens junction: LEF1 CTNNB1
hsa04213__13	9.9581040671318e-19	DOWN	-8.8360092883805	6.75497384192803e-18	Longevity regulating pathway - multiple species: RPS6KB1*
hsa04010__117	1.14365281611444e-18	DOWN	-8.82052261192569	7.72994115639939e-18	MAPK signaling pathway: JUND
hsa05166__5	1.2734477835546e-18	UP	8.80847741912751	8.57637414085695e-18	HTLV-I infection: SLC2A1
hsa03320__31	1.36446154062766e-18	DOWN	-8.80073408090011	9.15651155299774e-18	PPAR signaling pathway: CD36
hsa05010__59	1.4731345340227e-18	UP	8.79213037175855	9.85060423284218e-18	Alzheimer's disease: LRP1
hsa04014__64	1.71675906926538e-18	UP	8.77492295347543	1.14389726636512e-17	Ras signaling pathway: PIK3R5*
hsa05110__13	2.04629263596879e-18	DOWN	-8.75513442244985	1.35865154169094e-17	Vibrio cholerae infection: C00238
hsa04010__118	2.1422036732624e-18	DOWN	-8.74997219696491	1.41732419086622e-17	MAPK signaling pathway: JUN
hsa04150__56	2.4570082093576e-18	DOWN	-8.73448552051011	1.61990120188875e-17	mTOR signaling pathway: EIF4B
hsa05162__93	2.67143790991071e-18	UP	8.72502144045439	1.75511602542735e-17	Measles: TP53
hsa05016__55	3.30422521986732e-18	UP	8.70093105485803	2.15577749587872e-17	Huntington's disease: TGM2
hsa05221__41	3.30422521986732e-18	DOWN	-8.70093105485803	2.15577749587872e-17	Acute myeloid leukemia: MAPK1
hsa04340__31	3.9628426797377e-18	DOWN	-8.68028215291829	2.57653335474988e-17	Hedgehog signaling pathway: GLI1***
hsa04022__49	4.71501796619494e-18	DOWN	-8.66049362189271	3.05500646844148e-17	cGMP-PKG signaling pathway: ATP1B4
hsa05200__201	4.93338780255657e-18	UP	8.65533139640777	3.18551054330028e-17	Pathways in cancer: PDGFB
hsa03320__38	5.20079454202334e-18	DOWN	-8.64930880000868	3.33525356466275e-17	PPAR signaling pathway: SORBS1
hsa04210__102	5.20079454202334e-18	DOWN	-8.64930880000868	3.33525356466275e-17	Apoptosis: PIDD1
hsa04151__51	5.24014551870019e-18	UP	8.64844842909453	3.34905898967267e-17	PI3K-Akt signaling pathway: NOS3
hsa04970__39	5.73583590105712e-18	UP	8.63812397812466	3.65343581630045e-17	Salivary secretion: KCNN4
hsa04724__5 71	6.9222170758349e-18	DOWN	-8.61661470527076	4.3942046910452e-17	Glutamatergic synapse: GRIN3A DLG4
hsa04970__32	7.18703847240979e-18	DOWN	-8.61231285069998	4.54695127597912e-17	Salivary secretion: RYR3
hsa04062__42	7.51804982753981e-18	UP	8.60715062521504	4.74040792817023e-17	Chemokine signaling pathway: PAK1
hsa04530__11 13	8.16444697425754e-18	DOWN	-8.59768654515933	5.09667636698668e-17	Tight junction: TJP1 EPB41
hsa05031__10	8.16444697425754e-18	DOWN	-8.59768654515933	5.09667636698668e-17	Amphetamine addiction: CACNA1C
hsa05031__53	8.16444697425754e-18	DOWN	-8.59768654515933	5.09667636698668e-17	Amphetamine addiction: CACNA1C*
hsa04022__71	8.53983780986651e-18	UP	8.59252431967439	5.31336266382092e-17	cGMP-PKG signaling pathway: PPIF
hsa04530__11 62	8.60403800022337e-18	UP	8.59166394876024	5.33563940673918e-17	Tight junction: TJP1 SHROOM1
hsa04310__32	9.91843733278115e-18	DOWN	-8.57531690139128	6.1305078119394e-17	Wnt signaling pathway: PPARD
hsa04064__3	1.02194316433752e-17	DOWN	-8.57187541773465	6.29584001898426e-17	NF-kappa B signaling pathway: BCL2
hsa04350__50	1.04510765093651e-17	DOWN	-8.56929430499219	6.41750743826702e-17	TGF-beta signaling pathway: AMHR2
hsa04210__56	1.143061494433e-17	UP	8.55896985402232	6.99613207830494e-17	Apoptosis: BAX
hsa04921__60	1.15162189348071e-17	UP	8.55810948310816	7.02564135665664e-17	Oxytocin signaling pathway: ELK1
hsa04510__44	1.20432902074167e-17	DOWN	-8.55294725762323	7.32341174748738e-17	Focal adhesion: BCL2
hsa05200__185	1.21334204532519e-17	DOWN	-8.55208688670907	7.35441839730979e-17	Pathways in cancer: HHIP
hsa05166__114 112 113	1.23156825549516e-17	DOWN	-8.55036614488076	7.44088987805597e-17	HTLV-I infection: DLG1 CTNNB1 APC2
hsa03320__61	1.28788351742688e-17	DOWN	-8.54520391939582	7.75619592706763e-17	PPAR signaling pathway: APOA1
hsa05200__196	1.36694049354012e-17	DOWN	-8.53832095208258	8.20601018326483e-17	Pathways in cancer: TRAF1
hsa05200__199	1.41876325998722e-17	UP	8.5340190975118	8.46303544608248e-17	Pathways in cancer: BCL2L1**
hsa05220__3	1.41876325998722e-17	UP	8.5340190975118	8.46303544608248e-17	Chronic myeloid leukemia: BCL2L1
hsa04068__55	1.49458650765634e-17	DOWN	-8.52799650111271	8.88711407558942e-17	FoxO signaling pathway: ATM
hsa04919__28	1.70841169352501e-17	DOWN	-8.5125098246579	1.01265160004211e-16	Thyroid hormone signaling pathway: RCAN1
hsa03320__23	2.14962884816691e-17	DOWN	-8.48583832631907	1.27017377537912e-16	PPAR signaling pathway: ACADL
hsa05133__30	2.23062727213468e-17	UP	8.48153647174829	1.31390239634516e-16	Pertussis: NOS2
hsa04022__50	2.36653072419371e-17	DOWN	-8.47465350443504	1.38959725961249e-16	cGMP-PKG signaling pathway: ATP2B1
hsa03320__65	2.492125929662e-17	DOWN	-8.46863090803595	1.45878648655293e-16	PPAR signaling pathway: ME1
hsa04012__22	2.62429269266565e-17	UP	8.46260831163686	1.53138073587539e-16	ErbB signaling pathway: EIF4EBP1
hsa05166__39	2.74306526957613e-17	UP	8.45744608615193	1.59573363514971e-16	HTLV-I infection: RRAS2
hsa04932__35	2.80442475986838e-17	DOWN	-8.45486497340946	1.62639324808416e-16	Non-alcoholic fatty liver disease (NAFLD): PRKAG2
hsa04742__48	2.99674377099933e-17	UP	8.44712163518206	1.73257893714085e-16	Taste transduction: GABBR1
hsa04933__56	3.01889960922244e-17	DOWN	-8.4462612642679	1.74003446801502e-16	AGE-RAGE signaling pathway in diabetic complications: NFATC1
hsa04115__31	3.06369719586044e-17	DOWN	-8.44454052243959	1.76045474954794e-16	p53 signaling pathway: ADGRB1
hsa04211__57	3.17858043453462e-17	DOWN	-8.44023866786881	1.80986443530017e-16	Longevity regulating pathway - mammal: ATG5
hsa05200__173	3.17858043453462e-17	UP	8.44023866786881	1.80986443530017e-16	Pathways in cancer: CCNA1
hsa05221__16	3.17858043453462e-17	UP	8.44023866786881	1.80986443530017e-16	Acute myeloid leukemia: CCNA1
hsa04014__68	3.37129295122811e-17	UP	8.43335570055556	1.91379439738901e-16	Ras signaling pathway: RALGDS*
hsa05215__24	4.48876340041523e-17	UP	8.39980123490349	2.54047784017476e-16	Prostate cancer: CDKN1A
hsa04916__8	4.93699720948761e-17	DOWN	-8.38861641301946	2.78577109808625e-16	Melanogenesis: TYR*
hsa04110__48	5.27289130846013e-17	UP	8.38087307479206	2.96639603850197e-16	Cell cycle: RB1*
hsa04310__13	5.50924180525672e-17	UP	8.37571084930712	3.0901090603216e-16	Wnt signaling pathway: NFATC1
hsa03320__37	5.54963678065054e-17	DOWN	-8.37485047839297	3.10350223536975e-16	PPAR signaling pathway: HMGCS2
hsa03320__60	5.71415858599638e-17	DOWN	-8.37140899473634	3.18602492079739e-16	PPAR signaling pathway: CYP27A1
hsa04110__43 83 84 85	5.7560350327716e-17	DOWN	-8.37054862382219	3.19987864691652e-16	Cell cycle: SMC1B SMC3 STAG1 RAD21
hsa04670__28 41 49	5.84069805560655e-17	UP	8.36882788199388	3.23736626739962e-16	Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1
hsa05205__215 216	6.80725584026146e-17	DOWN	-8.3507600927966	3.76200991877979e-16	Proteoglycans in cancer: EIF4B RPS6
hsa04213__61	7.00848700192101e-17	DOWN	-8.34731860913998	3.86186131278873e-16	Longevity regulating pathway - multiple species: ATG5
hsa04022__44	7.21558248482882e-17	DOWN	-8.34387712548336	3.96435072777583e-16	cGMP-PKG signaling pathway: BAD
hsa04152__62	7.32138177955348e-17	UP	8.34215638365504	4.01075112646676e-16	AMPK signaling pathway: EIF4EBP1
hsa04650__14	8.40592527286835e-17	UP	8.32580933628608	4.59149232201152e-16	Natural killer cell mediated cytotoxicity: CSF2
hsa04390__13	8.59107583106039e-17	UP	8.32322822354362	4.67902361929347e-16	Hippo signaling pathway: BIRC5
hsa03320__28	8.84421208397972e-17	DOWN	-8.31978673988699	4.80296951034621e-16	PPAR signaling pathway: ACSL1
hsa04115__16	9.10470060478282e-17	UP	8.31634525623037	4.93018225832476e-16	p53 signaling pathway: PPM1D
hsa04924__31	9.4408115451907e-17	DOWN	-8.31204340165959	5.09749565902682e-16	Renin secretion: C02135
hsa03460__25 40	9.5788830007237e-17	UP	8.31032265983128	5.15722669293978e-16	Fanconi anemia pathway: MLH1 PMS2
hsa04921__76	1.0373664765543e-16	UP	8.30085857977556	5.56917602698721e-16	Oxytocin signaling pathway: CDKN1A
hsa04152__15	1.08342341873096e-16	DOWN	-8.29569635429063	5.79986496807826e-16	AMPK signaling pathway: FOXO1
hsa04750__62	1.16465666343795e-16	UP	8.28709264514907	6.21701667784063e-16	Inflammatory mediator regulation of TRP channels: TRPM8*
hsa04022__23	1.28868886621615e-16	UP	8.27504745235089	6.85962147201176e-16	cGMP-PKG signaling pathway: CACNA1C
hsa04022__39	1.44637139724381e-16	DOWN	-8.2612815177244	7.67720863113312e-16	cGMP-PKG signaling pathway: KCNJ8
hsa03320__25	1.54327476475482e-16	DOWN	-8.25353817949699	8.16848812105441e-16	PPAR signaling pathway: EHHADH
hsa05166__64	1.58837151206057e-16	UP	8.25009669584037	8.38356761562308e-16	HTLV-I infection: CCNB2
hsa04972__23	1.70687601802205e-16	DOWN	-8.24149298669881	8.98380962986957e-16	Pancreatic secretion: KCNMA1
hsa05200__226	1.75668159827535e-16	UP	8.23805150304219	9.22012492502619e-16	Pathways in cancer: CDKN1A*
hsa05205__238	1.8875503382991e-16	UP	8.22944779390063	9.87940692385519e-16	Proteoglycans in cancer: ITGAV*
hsa04211__39	1.94254845008366e-16	UP	8.22600631024401	1.01390237158533e-15	Longevity regulating pathway - mammal: TP53*
hsa04360__51	2.10207070819159e-16	UP	8.21654223018829	1.09412489215845e-15	Axon guidance: FYN
hsa04971__37	2.17878507431431e-16	DOWN	-8.21224037561751	1.13092186592171e-15	Gastric acid secretion: KCNQ1
hsa04014__33	2.32388772820706e-16	UP	8.20449703739011	1.20291598933914e-15	Ras signaling pathway: BCL2L1
hsa04730__8	2.46083863903836e-16	UP	8.19761407007686	1.27030653921788e-15	Long-term depression: GNA13*
hsa04012__8	2.56874394798268e-16	DOWN	-8.19245184459193	1.32237530911218e-15	ErbB signaling pathway: STAT5A
hsa04960__27	2.71990226235652e-16	DOWN	-8.18556887727868	1.39636512321527e-15	Aldosterone-regulated sodium reabsorption: KCNJ1
hsa04014__24	2.75904159659325e-16	UP	8.18384813545037	1.41259922615769e-15	Ras signaling pathway: PLD1
hsa04931__124	2.77881892210398e-16	DOWN	-8.18298776453621	1.41885890071559e-15	Insulin resistance: FOXO1*
hsa03320__7	2.81879371831554e-16	DOWN	-8.1812670227079	1.43536948420458e-15	PPAR signaling pathway: AQP7
hsa04623__25	2.98443965956113e-16	UP	8.17438405539466	1.51561138386902e-15	Cytosolic DNA-sensing pathway: NFKB1*
hsa05221__21	3.02732821745541e-16	DOWN	-8.17266331356634	1.53324790312634e-15	Acute myeloid leukemia: PIM1
hsa04150__33	3.04899973429092e-16	DOWN	-8.17180294265219	1.54007271525071e-15	mTOR signaling pathway: RPS6
hsa04722__85	3.34503713669309e-16	UP	8.16061812076816	1.68507366751912e-15	Neurotrophin signaling pathway: BAX
hsa04540__14 16	3.44169829880566e-16	DOWN	-8.15717663711154	1.72452029425489e-15	Gap junction: GJA1 GJA1
hsa04540__14 15	3.44169829880566e-16	DOWN	-8.15717663711154	1.72452029425489e-15	Gap junction: GJA1 GJA1*
hsa05212__10	3.49105605056954e-16	UP	8.15545589528323	1.7445995529309e-15	Pancreatic cancer: BCL2L1
hsa03320__9	3.77525497545826e-16	DOWN	-8.14599181522751	1.88161912437296e-15	PPAR signaling pathway: PCK1
hsa03460__28	3.82932361766615e-16	UP	8.1442710733992	1.89849579883765e-15	Fanconi anemia pathway: RAD51C
hsa04151__98	3.82932361766615e-16	UP	8.1442710733992	1.89849579883765e-15	PI3K-Akt signaling pathway: BCL2L1*
hsa04068__45	3.93976057035492e-16	DOWN	-8.14082958974258	1.94810792413076e-15	FoxO signaling pathway: RBL2
hsa04710__23	4.02464260194857e-16	UP	8.13824847700011	1.98485654831007e-15	Circadian rhythm: BHLHE41
hsa04910__18	4.50871118931262e-16	UP	8.12448254237362	2.21776657715142e-15	Insulin signaling pathway: LIPE
hsa05010__49	4.63843004234648e-16	DOWN	-8.12104105871699	2.26969011707527e-15	Alzheimer's disease: EIF2AK3
hsa05211__27	4.63843004234648e-16	DOWN	-8.12104105871699	2.26969011707527e-15	Renal cell carcinoma: VEGFA*
hsa04742__54	4.83781708097234e-16	DOWN	-8.11587883323206	2.35498919563395e-15	Taste transduction: P2RX2*
hsa04742__40	4.83781708097234e-16	DOWN	-8.11587883323206	2.35498919563395e-15	Taste transduction: P2RX2
hsa05140__43	4.90899944148856e-16	UP	8.11415809140375	2.3834651035031e-15	Leishmaniasis: MAPK14
hsa05220__25	5.38220725571968e-16	UP	8.10297326951972	2.60648645193229e-15	Chronic myeloid leukemia: BCL2L1*
hsa05215__39	5.65534566347629e-16	UP	8.09695067312063	2.73172095158662e-15	Prostate cancer: RB1
hsa04390__96	5.8175104776247e-16	UP	8.09350918946401	2.80284671473252e-15	Hippo signaling pathway: FGF1
hsa04920__5	6.15570782322144e-16	DOWN	-8.08662622215076	2.95647855423922e-15	Adipocytokine signaling pathway: NFKBIA
hsa04066__63	6.19932171564796e-16	UP	8.0857658512366	2.95647855423922e-15	HIF-1 signaling pathway: TIMP1*
hsa04066__57	6.19932171564796e-16	UP	8.0857658512366	2.95647855423922e-15	HIF-1 signaling pathway: TIMP1
hsa05014__49	6.19932171564796e-16	UP	8.0857658512366	2.95647855423922e-15	Amyotrophic lateral sclerosis (ALS): C00001
hsa04110__10 11 12 13 14 9 15 16 17 18 19 20	7.55211224500829e-16	UP	8.06167546564024	3.59251111604318e-15	Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
hsa04068__51	7.6054588546112e-16	DOWN	-8.06081509472608	3.59966176015477e-15	FoxO signaling pathway: BCL6
hsa04068__56	7.6054588546112e-16	DOWN	-8.06081509472608	3.59966176015477e-15	FoxO signaling pathway: BCL6*
hsa04960__4	8.10254695165235e-16	DOWN	-8.05307175649868	3.82529792013939e-15	Aldosterone-regulated sodium reabsorption: ATP1B4
hsa04010__131	8.217341547854e-16	DOWN	-8.05135101467037	3.86977061865105e-15	MAPK signaling pathway: MYC
hsa04911__56	8.45166285132149e-16	UP	8.04790953101375	3.97016862440827e-15	Insulin secretion: CAMK2A*
hsa04919__30	9.59021025931604e-16	DOWN	-8.03242285455894	4.49376685218325e-15	Thyroid hormone signaling pathway: MYH6
hsa05030__80 81	1.01435256584856e-15	DOWN	-8.0255398872457	4.74121510256079e-15	Cocaine addiction: GRIN3A DLG4
hsa04022__51	1.08036521528004e-15	DOWN	-8.01779654901829	5.03723632633049e-15	cGMP-PKG signaling pathway: GTF2I
hsa05211__23	1.40896131629103e-15	UP	7.98510245428037	6.55306513195754e-15	Renal cell carcinoma: PDGFB
hsa03320__64	1.55336375945898e-15	DOWN	-7.97305726148219	7.20684075067512e-15	PPAR signaling pathway: APOA5
hsa05162__23	1.60839133663342e-15	UP	7.96875540691141	7.44376187569998e-15	Measles: IRF3
hsa05169__117	1.7004542025117e-15	UP	7.96187243959816	7.85049986859823e-15	Epstein-Barr virus infection: CDKN1A
hsa03320__45	1.82285843808234e-15	DOWN	-7.9532687304566	8.39497795381547e-15	PPAR signaling pathway: PDPK1
hsa04068__50	1.96753810984454e-15	DOWN	-7.94380465040089	9.0391298493836e-15	FoxO signaling pathway: TNFSF10
hsa04012__24	2.00892128785904e-15	UP	7.94122353765842	9.20673926801742e-15	ErbB signaling pathway: CDKN1A
hsa04115__29	2.24453747424082e-15	DOWN	-7.92745760303193	1.02615229053491e-14	p53 signaling pathway: IGF1
hsa04068__57	2.27583960395666e-15	DOWN	-7.92573686120362	1.03793752811518e-14	FoxO signaling pathway: IL7R
hsa04340__14	2.81973866594505e-15	DOWN	-7.89906536286479	1.28287868118904e-14	Hedgehog signaling pathway: PTCH1
hsa04727__8	3.12703033121479e-15	DOWN	-7.88615979915245	1.41924879042333e-14	GABAergic synapse: ADCY1
hsa05130__28	3.19233300606531e-15	UP	7.88357868640998	1.4453960767221e-14	Pathogenic Escherichia coli infection: ROCK1
hsa04742__34	3.3731099909103e-15	UP	7.87669571909673	1.52357540214434e-14	Taste transduction: GRM1
hsa03320__20	3.41985674516208e-15	DOWN	-7.87497497726842	1.54098580915097e-14	PPAR signaling pathway: SCP2
hsa04360__101 103	3.73964352235663e-15	UP	7.8637901553844	1.68105028193974e-14	Axon guidance: DPYSL2 DPYSL5
hsa04022__43	3.97810113692344e-15	DOWN	-7.85604681715699	1.78397423300218e-14	cGMP-PKG signaling pathway: MAPK1
hsa04923__16	4.00550319642249e-15	DOWN	-7.85518644624284	1.79198583478044e-14	Regulation of lipolysis in adipocytes: PLIN1
hsa04380__20	4.11698197267223e-15	UP	7.85174496258622	1.83748435312378e-14	Osteoclast differentiation: MAP2K1
hsa04010__129	4.47006881516632e-15	DOWN	-7.84142051161635	1.99034580656339e-14	MAPK signaling pathway: FOS
hsa05152__126	4.81982702754187e-15	UP	7.83195643156063	2.14100590656056e-14	Tuberculosis: NOS2
hsa04064__137	4.85292799334158e-15	UP	7.83109606064648	2.14556510576208e-14	NF-kappa B signaling pathway: ICAM1
hsa05200__220	4.85292799334158e-15	UP	7.83109606064648	2.14556510576208e-14	Pathways in cancer: CSF1R*
hsa04115__38	4.8862527224395e-15	UP	7.83023568973232	2.15522743320747e-14	p53 signaling pathway: GTSE1
hsa05168__79	5.09098412769477e-15	DOWN	-7.82507346424738	2.24027146977482e-14	Herpes simplex infection: EIF2S1
hsa04115__17	5.37714521929397e-15	UP	7.81819049693414	2.36066725865733e-14	p53 signaling pathway: TP73
hsa04066__47	6.37734568672163e-15	DOWN	-7.79668122408024	2.79324767956875e-14	HIF-1 signaling pathway: PGK1
hsa05110__46	6.55353621043869e-15	DOWN	-7.79323974042362	2.86374291614286e-14	Vibrio cholerae infection: PLCG1
hsa05205__30	7.01524591779535e-15	DOWN	-7.78463603128206	3.05838679339616e-14	Proteoglycans in cancer: FLNA
hsa04014__62	7.25796089348613e-15	UP	7.78033417671128	3.15687697195844e-14	Ras signaling pathway: RASSF5
hsa05231__39	7.40753749966092e-15	UP	7.77775306396881	3.21449491036094e-14	Choline metabolism in cancer: EIF4EBP1
hsa04916__7	7.50893650755243e-15	DOWN	-7.7760323221405	3.25098887043572e-14	Melanogenesis: TYRP1
hsa05161__92	7.61170133073659e-15	DOWN	-7.77431158031219	3.28790501159863e-14	Hepatitis B: NFKBIA
hsa05130__26	8.37074123561201e-15	DOWN	-7.76226638751401	3.60748228938417e-14	Pathogenic Escherichia coli infection: CTNNB1
hsa04151__26	9.08049407043639e-15	DOWN	-7.75194193654414	3.90440465866132e-14	PI3K-Akt signaling pathway: RBL2
hsa04726__64	9.14223594981069e-15	UP	7.75108156562998	3.92197747709915e-14	Serotonergic synapse: CASP3
hsa04152__78	9.52145800689424e-15	UP	7.74591934014505	4.07535753871396e-14	AMPK signaling pathway: CCNA2
hsa04213__55	1.09007884575759e-14	DOWN	-7.72871192186193	4.65513216176935e-14	Longevity regulating pathway - multiple species: CRYAB
hsa04066__51	1.13516647127413e-14	DOWN	-7.72354969637699	4.83668435266234e-14	HIF-1 signaling pathway: TFRC
hsa04213__52	1.15839347657169e-14	DOWN	-7.72096858363453	4.92448267529004e-14	Longevity regulating pathway - multiple species: SOD2
hsa04330__19	1.26456615858063e-14	UP	7.7097837617505	5.36370160716254e-14	Notch signaling pathway: DTX2
hsa04211__51	1.34362188178953e-14	UP	7.7020404235231	5.6734056536686e-14	Longevity regulating pathway - mammal: NFKB1
hsa04510__23 4 5	1.34362188178953e-14	UP	7.7020404235231	5.6734056536686e-14	Focal adhesion: TLN1 ITGB1 ITGA11
hsa04550__53 64	1.36183948575147e-14	DOWN	-7.70031968169479	5.73743586037447e-14	Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4
hsa05120__52	1.4664659630401e-14	UP	7.69085560163907	6.16440613993812e-14	Epithelial cell signaling in Helicobacter pylori infection: LYN
hsa05130__55	1.50644045374042e-14	UP	7.68741411798245	6.31830717093359e-14	Pathogenic Escherichia coli infection: ACTB
hsa04010__120	1.56842027312964e-14	DOWN	-7.68225189249751	6.56361178888774e-14	MAPK signaling pathway: NFATC1
hsa04510__26 4 5	1.70000116321447e-14	UP	7.67192744152764	7.09844930151109e-14	Focal adhesion: ACTN4 ITGB1 ITGA11
hsa04360__131	1.83012345572848e-14	UP	7.66246336147193	7.62483807830112e-14	Axon guidance: RAC1****
hsa05216__12	1.88902425033186e-14	UP	6.7453079669818	7.85282426188843e-14	Thyroid cancer: CDH1
hsa04917__65	2.06448827948329e-14	DOWN	-7.64697668501712	8.5632968590488e-14	Prolactin signaling pathway: CYP17A1
hsa05218__8	2.20719887807086e-14	UP	7.63837297587557	9.13508081915231e-14	Melanoma: CDK4
hsa04950__13	2.60780808080602e-14	DOWN	-7.61686370302167	1.07693876567791e-13	Maturity onset diabetes of the young: INS
hsa04920__28	2.62523919258598e-14	DOWN	-7.61600333210751	1.08175974624321e-13	Adipocytokine signaling pathway: SLC2A1
hsa04510__6 4 5	2.64278489178769e-14	UP	7.61514296119336	1.08660674215953e-13	Focal adhesion: FLNA ITGB1 ITGA11
hsa04650__35	2.66044591860456e-14	UP	7.6142825902792	1.09147988669388e-13	Natural killer cell mediated cytotoxicity: BID
hsa04213__2	2.82470938135418e-14	DOWN	-7.6065392520518	1.15634617158268e-13	Longevity regulating pathway - multiple species: RPS6KB1
hsa04010__78	2.93971858321654e-14	DOWN	-7.60137702656686	1.20081113431823e-13	MAPK signaling pathway: MAP3K4
hsa04066__53	3.0593301866776e-14	DOWN	-7.59621480108193	1.24695909344191e-13	HIF-1 signaling pathway: EGF*
hsa04115__24	3.12091813919681e-14	UP	7.59363368833946	1.26930848128806e-13	p53 signaling pathway: SERPINB5
hsa04213__60	3.93603482936345e-14	DOWN	-7.56352070634401	1.59736705062072e-13	Longevity regulating pathway - multiple species: CAT
hsa04970__21	3.96216509696768e-14	UP	7.56266033542985	1.60450608129359e-13	Salivary secretion: ITPR1
hsa04530__5 10	4.2330316806718e-14	DOWN	-7.55405662628829	1.71050893074889e-13	Tight junction: IGSF5 MAGI1
hsa04670__10	4.26109948468444e-14	UP	7.55319625537414	1.7181557793395e-13	Leukocyte transendothelial migration: BCAR1
hsa05220__6	4.67380540924854e-14	UP	7.54115106257596	1.88053112719015e-13	Chronic myeloid leukemia: TP53
hsa04211__23	5.05865037455655e-14	DOWN	-7.53082661160609	2.03102650722046e-13	Longevity regulating pathway - mammal: SOD2
hsa05211__41	5.96321002664744e-14	UP	7.50931733875219	2.38909843071866e-13	Renal cell carcinoma: PDGFB*
hsa05217__10	6.66730130326693e-14	DOWN	-7.49469103321154	2.6655019465614e-13	Basal cell carcinoma: PTCH1*
hsa03320__39	8.43899342488621e-14	UP	7.46371768030193	3.36663877820832e-13	PPAR signaling pathway: MMP1
hsa04151__33	9.12668554575146e-14	UP	7.45339322933206	3.63327163992945e-13	PI3K-Akt signaling pathway: TP53
hsa04022__37 38	9.80528719938619e-14	DOWN	-7.44392914927635	3.89516588745172e-13	cGMP-PKG signaling pathway: ATP2A1 PLN
hsa03460__48	9.99881141653435e-14	UP	7.44134803653388	3.96366385056288e-13	Fanconi anemia pathway: RAD51
hsa04622__5 33	1.03971894305603e-13	UP	7.43618581104894	4.11290925053113e-13	RIG-I-like receptor signaling pathway: MAVS TMEM173
hsa05142__36	1.06021874223816e-13	UP	7.43360469830648	4.18519121148213e-13	Chagas disease (American trypanosomiasis): SMAD2
hsa04115__23	1.08111564471011e-13	UP	7.43102358556401	4.25873437402577e-13	p53 signaling pathway: PTEN
hsa05164__90	1.11684683817052e-13	DOWN	-7.42672173099323	4.3902828638544e-13	Influenza A: MAPK1
hsa05211__3	1.13883997932945e-13	DOWN	-7.42414061825076	4.46739106713994e-13	Renal cell carcinoma: VEGFA
hsa04810__32	1.1995905079025e-13	UP	7.41725765093751	4.69589700906001e-13	Regulation of actin cytoskeleton: PXN
hsa04114__59	1.23916515225675e-13	UP	7.41295579636674	4.8407303972774e-13	Oocyte meiosis: REC8*
hsa05222__19	1.34816250054241e-13	DOWN	-7.40177097448271	5.25559613800661e-13	Small cell lung cancer: CASP9
hsa04933__29	1.38355697205462e-13	UP	7.39832949082609	5.38240900722698e-13	AGE-RAGE signaling pathway in diabetic complications: ICAM1
hsa04115__58	1.39254730727604e-13	UP	7.39746911991193	5.40619088919769e-13	p53 signaling pathway: CASP3
hsa04152__63	1.41986414633776e-13	DOWN	-7.39488800716946	5.50087573395598e-13	AMPK signaling pathway: PPARG
hsa04211__56	1.57469043469988e-13	DOWN	-7.38112207254297	6.08815499341784e-13	Longevity regulating pathway - mammal: CAT
hsa04919__40	1.69063659045246e-13	DOWN	-7.37165799248725	6.52301058205373e-13	Thyroid hormone signaling pathway: RCAN2
hsa04913__35	1.70158392520265e-13	DOWN	-7.3707976215731	6.55179548249136e-13	Ovarian steroidogenesis: HSD17B2
hsa04630__24	1.73484551342473e-13	UP	7.36821650883063	6.66620597080789e-13	Jak-STAT signaling pathway: MCL1
hsa04068__44	1.81496012014489e-13	DOWN	-7.36219391243154	6.95981646071889e-13	FoxO signaling pathway: CDKN1B
hsa04742__4	1.89870667143315e-13	DOWN	-7.35617131603245	7.2661300114519e-13	Taste transduction: TRPM5
hsa05160__66	1.91097627878072e-13	UP	7.35531094511829	7.28341668930827e-13	Hepatitis C: GSK3B
hsa05205__233 234	1.91097627878072e-13	UP	7.35531094511829	7.28341668930827e-13	Proteoglycans in cancer: ITGA2 C00925
hsa04360__58	1.97350237460626e-13	UP	7.35100909054751	7.50649992284447e-13	Axon guidance: PLXNC1
hsa05010__47	2.01197821634273e-13	DOWN	-7.34842797780505	7.63738801718786e-13	Alzheimer's disease: C00533
hsa04810__21 82	2.11821979334611e-13	UP	7.3415450104918	8.02446570906724e-13	Regulation of actin cytoskeleton: CFL1 ACTB
hsa04925__3	2.17338822310743e-13	DOWN	-7.33810352683518	8.21689430828743e-13	Aldosterone synthesis and secretion: ITPR1
hsa04151__25	2.24433693569187e-13	DOWN	-7.3338016722644	8.46809056659643e-13	PI3K-Akt signaling pathway: CDKN1B
hsa04919__84	2.43962468290282e-13	UP	7.32261685038037	9.18648252339561e-13	Thyroid hormone signaling pathway: TP53*
hsa04920__43	2.6686126995779e-13	DOWN	-7.31057165758219	1.00286465250138e-12	Adipocytokine signaling pathway: C00162
hsa04664__25	2.68575390500571e-13	UP	7.30971128666803	1.00729173403308e-12	Fc epsilon RI signaling pathway: MAPK14
hsa05200__183	2.70300324586196e-13	DOWN	-7.30885091575388	1.01174165318219e-12	Pathways in cancer: BMP2
hsa05161__57	2.90007729464928e-13	UP	7.29938683569816	1.08334895360755e-12	Hepatitis B: STAT3*
hsa05205__400	2.93739515889602e-13	UP	7.29766609386985	1.09511220308842e-12	Proteoglycans in cancer: ITGA2*
hsa04923__52 53	3.17141180192245e-13	DOWN	-7.28734164289998	1.18001639124996e-12	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5*
hsa05145__29	3.23252098854487e-13	UP	7.28476053015751	1.19572459144361e-12	Toxoplasmosis: C06314
hsa04068__47	3.23272002370066e-13	DOWN	-7.28476053015751	1.19572459144361e-12	FoxO signaling pathway: GADD45G
hsa04068__54	3.23272002370066e-13	DOWN	-7.28476053015751	1.19572459144361e-12	FoxO signaling pathway: GADD45G*
hsa05200__189	3.27423728773475e-13	UP	7.2830397883292	1.20870174138578e-12	Pathways in cancer: BIRC5
hsa04550__25	3.62577707503191e-13	UP	7.26927385370271	1.33585002431078e-12	Signaling pathways regulating pluripotency of stem cells: MAPK1
hsa04540__16 17	4.17031699264322e-13	DOWN	-7.25034569359128	1.53346881197194e-12	Gap junction: GJA1 GJA1**
hsa04210__114	4.22362979614651e-13	UP	7.24862495176297	1.55003913807799e-12	Apoptosis: HRK
hsa05110__52	5.51120073170321e-13	DOWN	-7.21248937336842	2.01862498535484e-12	Vibrio cholerae infection: ADCY3
hsa04071__66	5.54614059205201e-13	UP	7.21162900245427	2.02747046156921e-12	Sphingolipid signaling pathway: C01245
hsa05219__19	5.79688313251884e-13	DOWN	-7.20560640605518	2.11501813708794e-12	Bladder cancer: TP53
hsa04950__5	6.87259650124607e-13	DOWN	-7.18237639137297	2.5026373693491e-12	Maturity onset diabetes of the young: GCK
hsa05205__318	7.27296963276533e-13	UP	7.17463305314557	2.64330946614431e-12	Proteoglycans in cancer: HSPB2
hsa04550__36	7.36500337623452e-13	DOWN	-7.17291231131726	2.67159099303951e-12	Signaling pathways regulating pluripotency of stem cells: AKT3*
hsa05219__27	7.4114479763455e-13	DOWN	-7.1720519404031	2.68325833286189e-12	Bladder cancer: RPS6KA5
hsa04920__16	9.76597042942329e-13	DOWN	-7.13419562018024	3.52889585324738e-12	Adipocytokine signaling pathway: POMC
hsa04610__58	9.88887511962947e-13	UP	7.13247487835193	3.56644843565907e-12	Complement and coagulation cascades: F2RL2
hsa05213__27	1.15593631034442e-12	UP	7.11096560549804	4.1609278297647e-12	Endometrial cancer: ELK1
hsa04211__52	1.20747709804901e-12	DOWN	-7.10494300909894	4.33814429681472e-12	Longevity regulating pathway - mammal: PPARG
hsa04012__23	1.25344463480803e-12	DOWN	-7.09978078361401	4.4946993679471e-12	ErbB signaling pathway: RPS6KB1
hsa05168__138	1.28503910196198e-12	DOWN	-7.09633929995739	4.5992161382601e-12	Herpes simplex infection: CHUK
hsa04919__31	1.36748385661952e-12	DOWN	-7.08773559081583	4.88498510758191e-12	Thyroid hormone signaling pathway: ATP2A2
hsa05031__98	1.37600831427561e-12	DOWN	-7.08687521990167	4.9061093406525e-12	Amphetamine addiction: FOS
hsa04726__10	1.4641723189313e-12	UP	7.07827151076011	5.21056777892407e-12	Serotonergic synapse: PRKACA
hsa05222__44	1.69900281959268e-12	UP	7.05762260882037	6.02344584531066e-12	Small cell lung cancer: RB1
hsa05231__18	1.69900281959268e-12	DOWN	-7.05762260882037	6.02344584531066e-12	Choline metabolism in cancer: CHKA
hsa04068__53	1.72016213512099e-12	DOWN	-7.05590186699206	6.08697674555997e-12	FoxO signaling pathway: SOD2
hsa04664__47	1.95854532848837e-12	UP	7.03783407779479	6.91749374479257e-12	Fc epsilon RI signaling pathway: MAPK8
hsa04971__52 53	1.97067118527228e-12	DOWN	-7.03697370688063	6.94726295896175e-12	Gastric acid secretion: EZR ACTB
hsa04540__18 19	2.00748706337653e-12	DOWN	-7.03439259413816	7.06379811251781e-12	Gap junction: GJA1 GJA1***
hsa05161__69	2.01991533610453e-12	UP	7.03353222322401	7.09424470381385e-12	Hepatitis B: SMAD4
hsa04932__28	2.04498804109516e-12	UP	7.0318114813957	7.16890397242128e-12	Non-alcoholic fatty liver disease (NAFLD): GSK3A
hsa05222__34	2.22924941892949e-12	UP	7.01976628859752	7.80029731502515e-12	Small cell lung cancer: CCND1
hsa05010__12	2.2848222019232e-12	UP	7.01632480494089	7.97989018106636e-12	Alzheimer's disease: CASP3
hsa04064__54	2.49023744492984e-12	UP	7.00427961214271	8.68118025792797e-12	NF-kappa B signaling pathway: CCL13
hsa05200__80	2.73043006954055e-12	UP	6.99137404843037	9.50088537160497e-12	Pathways in cancer: TP53
hsa05161__188	2.92086945209437e-12	UP	6.98190996837466	1.0144757302191e-11	Hepatitis B: IFNB1
hsa04913__36	3.10526152213334e-12	DOWN	-6.9733062592331	1.07454629835885e-11	Ovarian steroidogenesis: CYP19A1
hsa04913__37	3.10526152213334e-12	DOWN	-6.9733062592331	1.07454629835885e-11	Ovarian steroidogenesis: CYP19A1*
hsa05200__219	3.36211721455307e-12	DOWN	-6.96212143734907	1.16129011877669e-11	Pathways in cancer: MYC**
hsa05200__207	3.42428734176368e-12	UP	6.95954032460661	1.18059374590348e-11	Pathways in cancer: CDK4
hsa04530__20 22	3.53041808906892e-12	UP	6.95523847003583	1.21495523614661e-11	Tight junction: ACTB MYL12B
hsa04724__26	3.66203806199667e-12	DOWN	-6.95007624455089	1.25794689551951e-11	Glutamatergic synapse: PRKACA
hsa04152__38	3.82168302874597e-12	UP	6.9440536481518	1.3103909509149e-11	AMPK signaling pathway: PFKL
hsa04014__38	4.03699822689194e-12	UP	6.9363103099244	1.3816975716448e-11	Ras signaling pathway: MAPK8
hsa05164__20	4.42257213318292e-12	DOWN	-6.92340474621206	1.51091146150013e-11	Influenza A: ATF2
hsa05161__48	4.44952337053901e-12	UP	6.92254437529791	1.51736014759397e-11	Hepatitis B: STAT1
hsa04910__9	4.4766355972063e-12	UP	6.92168400438375	1.52384026941135e-11	Insulin signaling pathway: ELK1
hsa04066__5	4.67100864896862e-12	DOWN	-6.91566140798466	1.58712934021917e-11	HIF-1 signaling pathway: VEGFA
hsa04911__54	4.69944313851131e-12	UP	6.9148010370705	1.593908602394e-11	Insulin secretion: RAB3A
hsa04210__69	4.8441803722539e-12	DOWN	-6.91049918249972	1.64003872422794e-11	Apoptosis: PTPN13
hsa05205__195	5.24125817309914e-12	UP	6.8993143606157	1.77128131425419e-11	Proteoglycans in cancer: CDKN1A
hsa05210__31	5.46810776633134e-12	DOWN	-6.89329176421661	1.84462737754696e-11	Colorectal cancer: BCL2
hsa04068__96	5.80895654052017e-12	DOWN	-6.88468805507505	1.95609844796369e-11	FoxO signaling pathway: CCNG2
hsa04914__42	5.91521173760914e-12	DOWN	-6.88210694233258	1.98831535867041e-11	Progesterone-mediated oocyte maturation: ARAF
hsa04210__24	6.39808812393166e-12	UP	6.87092212044855	2.14678706872635e-11	Apoptosis: CASP10
hsa04115__30	6.67388726241795e-12	UP	6.86489952404946	2.23533585848188e-11	p53 signaling pathway: SERPINE1
hsa04068__52	7.08819800573382e-12	DOWN	-6.85629581490791	2.36987972469286e-11	FoxO signaling pathway: CAT
hsa04919__103	7.48250339395435e-12	UP	6.8485524766805	2.49726889471407e-11	Thyroid hormone signaling pathway: CCND1
hsa04024__31	8.04197707860788e-12	UP	6.83822802571063	2.67449113817773e-11	cAMP signaling pathway: C00165
hsa04024__32	8.04197707860788e-12	UP	6.83822802571063	2.67449113817773e-11	cAMP signaling pathway: C01245
hsa05020__46	8.09040329188445e-12	DOWN	-6.83736765479648	2.68584236492065e-11	Prion diseases: PRKACA
hsa03320__27	8.74655223355847e-12	DOWN	-6.82618283291245	2.89344571247471e-11	PPAR signaling pathway: CPT1C
hsa04910__42	8.74655223355847e-12	DOWN	-6.82618283291245	2.89344571247471e-11	Insulin signaling pathway: PCK1
hsa05012__71	8.85202086608599e-12	DOWN	-6.82446209108414	2.92318931588323e-11	Parkinson's disease: PRKACA*
hsa05210__21	9.51150303259021e-12	UP	6.81413764011427	3.13545863126965e-11	Colorectal cancer: BIRC5
hsa04510__42	1.02190486430788e-11	UP	6.8038131891444	3.36280077063835e-11	Focal adhesion: BIRC2
hsa04727__26	1.08478468722364e-11	UP	6.79520948000284	3.54488769964039e-11	GABAergic synapse: KCNJ6
hsa05032__81	1.08478468722364e-11	UP	6.79520948000284	3.54488769964039e-11	Morphine addiction: KCNJ6
hsa05032__91	1.08478468722364e-11	UP	6.79520948000284	3.54488769964039e-11	Morphine addiction: KCNJ6**
hsa05032__85	1.08478468722364e-11	UP	6.79520948000284	3.54488769964039e-11	Morphine addiction: KCNJ6*
hsa04914__15	1.15833323650493e-11	DOWN	-6.78574539994713	3.77865998505689e-11	Progesterone-mediated oocyte maturation: ANAPC10
hsa04022__48	1.16525674011491e-11	DOWN	-6.78488502903297	3.79465756442965e-11	cGMP-PKG signaling pathway: SLC8A2
hsa04066__50	1.22212357034318e-11	DOWN	-6.77800206171972	3.9660970443434e-11	HIF-1 signaling pathway: TF
hsa04210__64	1.22212357034318e-11	UP	6.77800206171972	3.9660970443434e-11	Apoptosis: TNFRSF10D*
hsa04115__25	1.31255506979472e-11	UP	6.76767761074985	4.25222582093843e-11	p53 signaling pathway: CD82
hsa04360__29	1.33616793089866e-11	UP	6.76509649800739	4.31384801058175e-11	Axon guidance: RASA1
hsa05145__8	1.33616793089866e-11	DOWN	-6.76509649800739	4.31384801058175e-11	Toxoplasmosis: NFKB1
hsa04933__30	1.39289442959766e-11	UP	6.7590739016083	4.48927724393483e-11	AGE-RAGE signaling pathway in diabetic complications: CXCL8
hsa04540__14 31	1.47804394417907e-11	DOWN	-6.75047019246674	4.75555577245288e-11	Gap junction: GJA1 TJP1
hsa04520__64	1.61540700262365e-11	DOWN	-6.7375646287544	5.18863206483732e-11	Adherens junction: CTNND1**
hsa05215__25	1.69370105311579e-11	DOWN	-6.73068166144115	5.43082641434227e-11	Prostate cancer: FOXO1
hsa04621__6	1.88369809192693e-11	DOWN	-6.71519498498635	6.01950461688895e-11	NOD-like receptor signaling pathway: NFKB1
hsa05168__9	1.88369809192693e-11	DOWN	-6.71519498498635	6.01950461688895e-11	Herpes simplex infection: NFKB1
hsa04919__88	2.42607281884192e-11	DOWN	-6.67819903567765	7.72642512983724e-11	Thyroid hormone signaling pathway: FOXO1
hsa05200__202	2.42607281884192e-11	DOWN	-6.67819903567765	7.72642512983724e-11	Pathways in cancer: FIGF*
hsa04014__65	2.52777357758365e-11	UP	6.67217643927856	8.0366946739081e-11	Ras signaling pathway: MLLT4*
hsa04114__80	2.54263881284682e-11	UP	6.6713160683644	8.07030123199184e-11	Oocyte meiosis: CDC25C*
hsa04270__65	2.55751936340817e-11	DOWN	-6.67045569745024	8.10384297444174e-11	Vascular smooth muscle contraction: NPR2
hsa04932__31 133	2.61823552776841e-11	DOWN	-6.66701421379362	8.26841509692181e-11	Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA
hsa04750__53	2.61825810679536e-11	UP	6.66701421379362	8.26841509692181e-11	Inflammatory mediator regulation of TRP channels: TRPM8
hsa05162__62	2.71191080328094e-11	DOWN	-6.66185198830869	8.54979932779343e-11	Measles: IL12A
hsa04014__104	2.89219790517876e-11	UP	6.65238790825297	9.10291434477537e-11	Ras signaling pathway: BRAP*
hsa04670__14	2.94336979697933e-11	UP	6.6498067955105	9.24848135204709e-11	Leukocyte transendothelial migration: SIPA1
hsa04730__30	3.04838605803585e-11	DOWN	-6.64464457002557	9.56246644916421e-11	Long-term depression: C00025*
hsa04152__87	3.67349257286912e-11	DOWN	-6.61711270077258	1.15041542407018e-10	AMPK signaling pathway: CD36
hsa04115__50	3.84840761966935e-11	UP	6.61022973345933	1.20318767343739e-10	p53 signaling pathway: RCHY1
hsa04380__38	4.07854344418541e-11	UP	6.60162602431778	1.2730204537582e-10	Osteoclast differentiation: FOS
hsa04015__100 101 48	4.17432140128078e-11	UP	6.59818454066115	1.30075454610391e-10	Rap1 signaling pathway: PRKCI PARD6A PARD3
hsa04622__9 35	4.74176650215152e-11	UP	6.57925638054972	1.47512901614946e-10	RIG-I-like receptor signaling pathway: IRF3 PIN1
hsa05014__5	4.93765707318998e-11	UP	6.57323378415063	1.53099961064752e-10	Amyotrophic lateral sclerosis (ALS): TOMM40
hsa05205__45 46	4.93765707318998e-11	UP	6.57323378415063	1.53099961064752e-10	Proteoglycans in cancer: PAK1 FLNA
hsa04622__6	5.2011824093685e-11	DOWN	-6.56549044592323	1.61005300612906e-10	RIG-I-like receptor signaling pathway: NFKB1
hsa04933__78	5.63868244493683e-11	UP	6.55344525312505	1.74261255165071e-10	AGE-RAGE signaling pathway in diabetic complications: TGFB1
hsa04066__60	5.7040508966051e-11	UP	6.55172451129674	1.75991980865698e-10	HIF-1 signaling pathway: NOS3
hsa04932__138	5.73701251425389e-11	DOWN	-6.55086414038258	1.76718795316116e-10	Non-alcoholic fatty liver disease (NAFLD): CEBPA
hsa04310__22	5.90461772684636e-11	DOWN	-6.5465622858118	1.81583906853426e-10	Wnt signaling pathway: ROCK2
hsa04919__99	6.32671849975381e-11	DOWN	-6.53623783484193	1.94246798382964e-10	Thyroid hormone signaling pathway: WNT4
hsa04360__89	7.3872011497431e-11	UP	6.51300782015972	2.26436394133235e-10	Axon guidance: CAMK2A
hsa04931__67	9.60733134941457e-11	DOWN	-6.47343075810856	2.94009374683224e-10	Insulin resistance: IKBKB**
hsa04610__17	9.71762767927098e-11	UP	6.47171001628024	2.96901177387808e-10	Complement and coagulation cascades: PLG
hsa03320__36	9.77312344236881e-11	DOWN	-6.47084964536609	2.98111995912516e-10	PPAR signaling pathway: SLC27A4
hsa04960__13	1.02283854215036e-10	DOWN	-6.46396667805284	3.1149329346848e-10	Aldosterone-regulated sodium reabsorption: FXYD4
hsa04152__24	1.08883741299153e-10	DOWN	-6.45450259799713	3.31055905988849e-10	AMPK signaling pathway: SIRT1
hsa04024__59	1.12657295721308e-10	UP	6.44934037251219	3.41424288161836e-10	cAMP signaling pathway: MLLT4
hsa05169__118	1.12657295721308e-10	UP	6.44934037251219	3.41424288161836e-10	Epstein-Barr virus infection: MDM2
hsa04670__45	1.14591714477696e-10	UP	6.44675925976972	3.46727586962304e-10	Leukocyte transendothelial migration: PXN
hsa03320__62	1.16558161224173e-10	DOWN	-6.44417814702726	3.52110586720613e-10	PPAR signaling pathway: UBC
hsa04071__1	1.2618230664385e-10	UP	6.43213295422908	3.8057231811203e-10	Sphingolipid signaling pathway: MAPK1
hsa04913__19	1.46157525984415e-10	DOWN	-6.40976331046102	4.40112165584481e-10	Ovarian steroidogenesis: STAR
hsa04724__66	1.61763880177484e-10	DOWN	-6.39427663400622	4.86326929365587e-10	Glutamatergic synapse: PLA2G4B
hsa05210__53	1.87216610097251e-10	UP	6.37190699023817	5.61948898359e-10	Colorectal cancer: CCND1*
hsa05016__52	1.90394030434327e-10	UP	6.3693258774957	5.6966621526449e-10	Huntington's disease: CASP3
hsa05205__109	1.90394030434327e-10	UP	6.3693258774957	5.6966621526449e-10	Proteoglycans in cancer: SMAD2
hsa04068__68	1.95807183498834e-10	DOWN	-6.36502402292492	5.84931157065675e-10	FoxO signaling pathway: ATG12
hsa04727__13	1.9690771640288e-10	DOWN	-6.36416365201076	5.87285077969861e-10	GABAergic synapse: CACNA1A
hsa04921__34 35	1.99126940954052e-10	UP	6.36244291018245	5.92962792476487e-10	Oxytocin signaling pathway: MYL9 ACTB
hsa04622__11	2.05932235012436e-10	UP	6.35728068469752	6.11290157327593e-10	RIG-I-like receptor signaling pathway: IRF7
hsa05014__2	2.05932235012436e-10	DOWN	-6.35728068469752	6.11290157327593e-10	Amyotrophic lateral sclerosis (ALS): SLC1A2
hsa04914__30	2.18999187117167e-10	UP	6.3478166046418	6.49052795888261e-10	Progesterone-mediated oocyte maturation: CDK1*
hsa05215__8	2.22706910990882e-10	DOWN	-6.34523549189934	6.59002024806089e-10	Prostate cancer: NFKBIA
hsa04610__45	2.30298052349763e-10	DOWN	-6.3400732664144	6.8039314522831e-10	Complement and coagulation cascades: C4A
hsa04728__24	2.42160828812558e-10	DOWN	-6.332329928187	7.14317421253997e-10	Dopaminergic synapse: SLC6A3
hsa05160__71	2.43515190989474e-10	DOWN	-6.33146955727284	7.17186589136711e-10	Hepatitis C: MAPK8
hsa04915__28	2.56042103360248e-10	UP	6.32372621904544	7.52900019114093e-10	Estrogen signaling pathway: KCNJ3
hsa05161__68	2.76789141228784e-10	UP	6.31168102624726	8.12635619326383e-10	Hepatitis B: JUN
hsa05168__10	3.21538785801782e-10	DOWN	-6.28845101156505	9.42545052295709e-10	Herpes simplex infection: FOS
hsa04750__60	3.26922448143395e-10	UP	6.28586989882258	9.56833769566106e-10	Inflammatory mediator regulation of TRP channels: TRPV3
hsa04064__93	3.32403375256876e-10	UP	6.28328878608011	9.71362273884402e-10	NF-kappa B signaling pathway: PLAU
hsa04621__23	3.37969267004389e-10	UP	6.28070767333765	9.86093560095103e-10	NOD-like receptor signaling pathway: CASP1
hsa05164__23	3.55218510538851e-10	UP	6.27296433511024	1.03321297415248e-09	Influenza A: IRF3
hsa05321__152	3.55218510538851e-10	UP	6.27296433511024	1.03321297415248e-09	Inflammatory bowel disease (IBD): FOXP3*
hsa04976__37	3.67152871553362e-10	DOWN	-6.26780210962531	1.06627549559315e-09	Bile secretion: ABCB11
hsa04930__26	3.81660474011547e-10	DOWN	-6.26177951322622	1.10499234309352e-09	Type II diabetes mellitus: INS*
hsa04931__35	3.81660474011547e-10	UP	6.26177951322622	1.10499234309352e-09	Insulin resistance: C00369
hsa05210__40	3.92334014624608e-10	DOWN	-6.25747765865544	1.13414709766098e-09	Colorectal cancer: CASP9
hsa04115__27	3.9887742419247e-10	UP	6.25489654591297	1.15129136721605e-09	p53 signaling pathway: THBS1
hsa04530__7 52	4.07767913364643e-10	DOWN	-6.25145506225635	1.17514710001866e-09	Tight junction: PARD6A MPP5
hsa04024__93	4.19153374805882e-10	UP	6.24715320768557	1.20610902183806e-09	cAMP signaling pathway: ORAI1
hsa04620__66	4.30848939475562e-10	UP	6.24285135311479	1.23786721295807e-09	Toll-like receptor signaling pathway: CASP8
hsa04152__81	4.45304547423311e-10	UP	6.23768912762985	1.27744617497466e-09	AMPK signaling pathway: LIPE
hsa04520__69	4.57711585973827e-10	UP	6.23338727305908	1.3110366921415e-09	Adherens junction: IQGAP1**
hsa04931__87	4.83546102730733e-10	DOWN	-6.22478356391752	1.38292713398942e-09	Insulin resistance: C00031*
hsa04917__56	4.86206496126095e-10	DOWN	-6.22392319300336	1.38842250185552e-09	Prolactin signaling pathway: LHCGR
hsa04950__30	4.88881172835884e-10	DOWN	-6.22306282208921	1.39394191769139e-09	Maturity onset diabetes of the young: PAX6*
hsa04068__66	5.1643014449799e-10	DOWN	-6.21445911294765	1.47026097198746e-09	FoxO signaling pathway: BNIP3
hsa04062__59	5.19266951979367e-10	DOWN	-6.21359874203349	1.47610076061911e-09	Chemokine signaling pathway: FOXO3
hsa04722__37	5.45492060144831e-10	DOWN	-6.20585540380609	1.54830752418752e-09	Neurotrophin signaling pathway: NFKB1
hsa05200__222	5.48484539545254e-10	UP	6.20499503289193	1.5544531671275e-09	Pathways in cancer: CASP9*
hsa04910__46	5.6061546667322e-10	DOWN	-6.20155354923531	1.58644045463702e-09	Insulin signaling pathway: FBP1
hsa04722__34	5.66778715261846e-10	UP	6.199832807407	1.60146948267219e-09	Neurotrophin signaling pathway: GSK3B
hsa05168__106 134	5.98600350691623e-10	DOWN	-6.19122909826544	1.6888439323567e-09	Herpes simplex infection: SRSF8 C1QBP
hsa04213__71	6.08482189369222e-10	DOWN	-6.18864798552297	1.71414997574928e-09	Longevity regulating pathway - multiple species: SIRT1**
hsa04024__12	6.18523132772975e-10	UP	6.1860668727805	1.73982779413236e-09	cAMP signaling pathway: SLC9A1
hsa04014__41	6.28725674632677e-10	UP	6.18348576003804	1.76588272441674e-09	Ras signaling pathway: RAC1*
hsa04110__96 97	6.85974707836252e-10	DOWN	-6.16971982541154	1.92380071048405e-09	Cell cycle: TFDP1 E2F4
hsa04261__73	7.04885812816857e-10	DOWN	-6.16541797084076	1.97389037598044e-09	Adrenergic signaling in cardiomyocytes: KCNE1
hsa05169__104	7.20380002357505e-10	UP	6.16197648718414	2.01427682206808e-09	Epstein-Barr virus infection: IRF3
hsa04950__15	7.7727042938178e-10	DOWN	-6.14993129438596	2.17012055989356e-09	Maturity onset diabetes of the young: IAPP
hsa04360__6	8.47662647023824e-10	UP	6.13616535975947	2.36314260201449e-09	Axon guidance: MAPK1
hsa04210__59	9.04499764287102e-10	UP	6.1258409087896	2.51785934384513e-09	Apoptosis: PMAIP1
hsa04917__31	9.0940052592181e-10	DOWN	-6.12498053787544	2.52775678728858e-09	Prolactin signaling pathway: GALT
hsa04914__29	9.80773187509094e-10	UP	6.11293534507726	2.72211642441593e-09	Progesterone-mediated oocyte maturation: CDK2
hsa05030__73	9.91426175376987e-10	DOWN	-6.11121460324895	2.74762504945923e-09	Cocaine addiction: NFKB1
hsa04360__82	1.04069080575112e-09	DOWN	-6.10347126502154	2.87990872460435e-09	Axon guidance: ILK
hsa04530__11 36 14	1.06334488881996e-09	DOWN	-6.10002978136492	2.93827212660692e-09	Tight junction: TJP1 CTNNB1 CTNNA1
hsa04913__12	1.08647954487139e-09	DOWN	-6.0965882977083	2.99339452318673e-09	Ovarian steroidogenesis: HSD3B1
hsa04923__31	1.08647954487139e-09	DOWN	-6.0965882977083	2.99339452318673e-09	Regulation of lipolysis in adipocytes: PRKACA*
hsa04024__109	1.09823017844341e-09	UP	6.09486755587999	3.02133895358003e-09	cAMP signaling pathway: BDNF
hsa04068__58	1.11608879416543e-09	DOWN	-6.09228644313752	3.06598076642814e-09	FoxO signaling pathway: KLF2
hsa04723__9	1.12815150548417e-09	DOWN	-6.09056570130921	3.08109982384413e-09	Retrograde endocannabinoid signaling: PRKCA
hsa04725__20	1.12815150548417e-09	DOWN	-6.09056570130921	3.08109982384413e-09	Cholinergic synapse: PRKCA
hsa04726__18	1.12815150548417e-09	DOWN	-6.09056570130921	3.08109982384413e-09	Serotonergic synapse: PRKCA
hsa04730__7	1.12815150548417e-09	DOWN	-6.09056570130921	3.08109982384413e-09	Long-term depression: GNA13
hsa05133__24	1.23594885449161e-09	DOWN	-6.07593939576856	3.37060652770644e-09	Pertussis: NFKB1
hsa04022__46	1.31802048462411e-09	DOWN	-6.06561494479869	3.58921810233146e-09	cGMP-PKG signaling pathway: VASP
hsa05200__227	1.36102480046707e-09	DOWN	-6.06045271931375	3.70096324179107e-09	Pathways in cancer: FOXO1
hsa05213__31	1.42049692837593e-09	DOWN	-6.0535697520005	3.85710076361036e-09	Endometrial cancer: MYC
hsa04550__9	1.47460702097061e-09	DOWN	-6.04754715560141	3.99824905108769e-09	Signaling pathways regulating pluripotency of stem cells: HNF1A
hsa04024__43	1.62313778355711e-09	UP	6.03206047914661	4.39463385490462e-09	cAMP signaling pathway: MAPK8
hsa04910__43	1.70277317652439e-09	DOWN	-6.02431714091921	4.60361265998464e-09	Insulin signaling pathway: G6PC
hsa05152__51	1.78621113891828e-09	UP	6.0165738026918	4.82225679601644e-09	Tuberculosis: CASP3
hsa04725__53	1.83424386156407e-09	DOWN	-6.01227194812102	4.94482670857804e-09	Cholinergic synapse: CHRNA7
hsa04390__77	1.9138050107536e-09	UP	6.00538898080778	5.15191921949286e-09	Hippo signaling pathway: CCND1
hsa03320__44	2.13890008716104e-09	DOWN	-5.9873211916105	5.74963270926407e-09	PPAR signaling pathway: FABP1
hsa04621__29	2.24308153932957e-09	UP	5.9795778533831	6.02107173200037e-09	NOD-like receptor signaling pathway: CASP5
hsa04621__33 35	2.44062772497076e-09	UP	5.96581191875661	6.54199642684744e-09	NOD-like receptor signaling pathway: NLRC4 PYCARD
hsa05152__98	2.50576432053734e-09	UP	5.96151006418583	6.70702444200808e-09	Tuberculosis: IL23A
hsa05152__68	2.54565570149445e-09	UP	5.95892895144336	6.80410677540266e-09	Tuberculosis: CD74
hsa04650__119	2.66907673253924e-09	UP	5.95118561321596	7.12385679039946e-09	Natural killer cell mediated cytotoxicity: KLRC4-KLRK1
hsa04932__58	2.82785508453379e-09	DOWN	-5.94172153316025	7.53693575012623e-09	Non-alcoholic fatty liver disease (NAFLD): BAX
hsa05221__27	2.87273093964426e-09	DOWN	-5.93914042041778	7.64569608440732e-09	Acute myeloid leukemia: PIM2
hsa05161__29	2.96457258098715e-09	UP	5.93397819493284	7.87897012683856e-09	Hepatitis B: NFKB1
hsa04668__116	3.09148662986704e-09	UP	5.9270952276196	8.20466578745787e-09	TNF signaling pathway: PGAM5
hsa04152__94	3.25758498623454e-09	DOWN	-5.91849151847804	8.63328940639591e-09	AMPK signaling pathway: MLYCD
hsa05031__8	3.39655924998631e-09	DOWN	-5.91160855116479	8.98892229679476e-09	Amphetamine addiction: DRD1
hsa05213__29	3.65416216686342e-09	UP	5.89956335836661	9.65706147895411e-09	Endometrial cancer: CCND1
hsa04360__123	3.95110092710258e-09	UP	5.88665779465427	1.04125086143419e-08	Axon guidance: ENAH
hsa04919__104	3.95110092710258e-09	DOWN	-5.88665779465427	1.04125086143419e-08	Thyroid hormone signaling pathway: MYC
hsa05210__9 11	4.07634088316092e-09	UP	5.88149556916934	1.07275133325761e-08	Colorectal cancer: SMAD2 SMAD4
hsa05030__37	4.49895742386469e-09	DOWN	-5.86514852180038	1.18231342649535e-08	Cocaine addiction: PRKACA
hsa05010__51	4.76280796048689e-09	DOWN	-5.85568444174466	1.24990449130655e-08	Alzheimer's disease: ATF6
hsa04068__67	5.06781919715602e-09	DOWN	-5.84535999077479	1.32624404894933e-08	FoxO signaling pathway: GABARAP
hsa04724__51	5.06781919715602e-09	UP	5.84535999077479	1.32624404894933e-08	Glutamatergic synapse: ADRBK1
hsa04024__9 95	5.39180308078086e-09	DOWN	-5.83503553980492	1.40906787048501e-08	cAMP signaling pathway: ATP1B4 FXYD1
hsa04066__42	5.44772429365447e-09	DOWN	-5.83331479797661	1.42170471496899e-08	HIF-1 signaling pathway: HK1
hsa04724__3	5.504209607543e-09	DOWN	-5.8315940561483	1.43445351630698e-08	Glutamatergic synapse: GRIK1
hsa05132__55	6.03889048562376e-09	UP	5.81610737969349	1.57161706682646e-08	Salmonella infection: IL18
hsa05161__45	6.10132927341013e-09	DOWN	-5.81438663786518	1.58567049858059e-08	Hepatitis B: PCNA
hsa05160__56	6.29243694322196e-09	DOWN	-5.80922441238025	1.63307859341354e-08	Hepatitis C: MAPK1
hsa04068__88	6.45612994486243e-09	DOWN	-5.80492255780947	1.67325078157193e-08	FoxO signaling pathway: FBXO32
hsa04933__19	6.55632596794702e-09	DOWN	-5.802341445067	1.69687830492733e-08	AGE-RAGE signaling pathway in diabetic complications: TGFBR2
hsa04015__14	7.11678285202179e-09	UP	5.78857551044051	1.83939958444965e-08	Rap1 signaling pathway: MAPK14
hsa04360__19	7.80304169341457e-09	DOWN	-5.7730888339857	2.01399936015467e-08	Axon guidance: CDC42
hsa05220__22	8.29585245293913e-09	DOWN	-5.76276438301583	2.1382588146876e-08	Chronic myeloid leukemia: CDKN1B
hsa04917__75	8.9545539875223e-09	UP	5.74985881930349	2.30487766336362e-08	Prolactin signaling pathway: CCND1**
hsa04921__77	9.04613421530617e-09	UP	5.74813807747518	2.3252648687497e-08	Oxytocin signaling pathway: KCNJ3
hsa04713__56	9.18521401637848e-09	UP	5.74555696473271	2.3577892263354e-08	Circadian entrainment: KCNJ3
hsa04115__11 12	9.23203419638155e-09	UP	5.74469659381856	2.36657465961813e-08	p53 signaling pathway: CDK2 CCNE1
hsa05133__94	9.27908634379427e-09	DOWN	-5.7438362229044	2.3753955367833e-08	Pertussis: IL12A
hsa05219__10	9.6150407161908e-09	DOWN	-5.73781362650531	2.45804918445204e-08	Bladder cancer: EGFR
hsa04919__38	9.663989153928e-09	UP	5.73695325559116	2.46720592666178e-08	Thyroid hormone signaling pathway: TP53
hsa04151__100	9.71317977566757e-09	DOWN	-5.736092884677	2.476399565601e-08	PI3K-Akt signaling pathway: PRKCA
hsa04670__35	9.76261374307943e-09	UP	5.73523251376284	2.48563024705234e-08	Leukocyte transendothelial migration: PTK2
hsa05161__227	1.02186643655794e-08	UP	5.72748917553544	2.59822332109929e-08	Hepatitis B: MYD88*
hsa05215__46	1.0270596878374e-08	DOWN	-5.72662880462128	2.60789885600874e-08	Prostate cancer: MTOR
hsa03320__33	1.04809040853699e-08	DOWN	-5.72318732096466	2.65770833689743e-08	PPAR signaling pathway: CYP7A1
hsa05162__44	1.06413752051034e-08	DOWN	-5.72060620822219	2.69476334371824e-08	Measles: PRKCQ
hsa04310__57	1.10251494935791e-08	UP	5.7145836118231	2.78819056506531e-08	Wnt signaling pathway: SIAH1
hsa05030__69	1.11372476756223e-08	DOWN	-5.71286286999479	2.81275381485139e-08	Cocaine addiction: PRKACA**
hsa04728__70 73	1.14802286131981e-08	DOWN	-5.70770064450986	2.89548316297976e-08	Dopaminergic synapse: KIF5A GRIA1
hsa05169__83	1.15968200493344e-08	UP	5.70597990268154	2.9209684815951e-08	Epstein-Barr virus infection: GSK3B
hsa04916__10	1.20140211538604e-08	UP	5.69995730628245	3.02200076949178e-08	Melanogenesis: CAMK2A
hsa04610__52	1.22589319188423e-08	UP	5.69651582262583	3.07948303148459e-08	Complement and coagulation cascades: CPB2
hsa03320__57	1.29577163767898e-08	DOWN	-5.68705174257012	3.25067410840962e-08	PPAR signaling pathway: APOC3
hsa04020__18	1.35579718076795e-08	DOWN	-5.67930840434271	3.38769003013694e-08	Calcium signaling pathway: C00002
hsa04020__17	1.35579718076795e-08	DOWN	-5.67930840434271	3.38769003013694e-08	Calcium signaling pathway: C00004
hsa04020__15	1.35579718076795e-08	DOWN	-5.67930840434271	3.38769003013694e-08	Calcium signaling pathway: C13051
hsa04970__12	1.47642154931631e-08	UP	5.66468209880206	3.68419135612928e-08	Salivary secretion: BEST2
hsa04931__13	1.59994857673411e-08	DOWN	-5.65091616417557	3.98713975554827e-08	Insulin resistance: AKT2
hsa04971__49	1.60797656062574e-08	DOWN	-5.65005579326141	4.00183835419306e-08	Gastric acid secretion: KCNJ1
hsa04620__29	1.67362426404648e-08	UP	5.64317282594817	4.15970898431658e-08	Toll-like receptor signaling pathway: CXCL8
hsa05034__62	1.77700148101989e-08	DOWN	-5.6328483749783	4.41081345156721e-08	Alcoholism: NPY
hsa04068__13	1.95348256463097e-08	DOWN	-5.61650132760934	4.84247195111027e-08	FoxO signaling pathway: PCK1
hsa05014__53	1.96322788267123e-08	DOWN	-5.61564095669518	4.86021764366173e-08	Amyotrophic lateral sclerosis (ALS): RAB5A
hsa04012__40	1.99274789372759e-08	UP	5.61305984395271	4.92680696357123e-08	ErbB signaling pathway: ELK1*
hsa05160__7	2.04290816579756e-08	UP	5.60875798938193	5.04418455129254e-08	Hepatitis C: IRF3
hsa04932__55	2.06331363849737e-08	UP	5.60703724755362	5.08788231855191e-08	Non-alcoholic fatty liver disease (NAFLD): CASP3
hsa05212__27	2.23383680101267e-08	UP	5.59327131292713	5.50115248899452e-08	Pancreatic cancer: BCL2L1*
hsa04961__5	2.25609085577158e-08	UP	5.59155057109882	5.54868418585707e-08	Endocrine and other factor-regulated calcium reabsorption: TRPV5
hsa04360__3	2.38238811594898e-08	DOWN	-5.5820864910431	5.84400426875734e-08	Axon guidance: GNAI1
hsa05161__78	2.38238811594898e-08	DOWN	-5.5820864910431	5.84400426875734e-08	Hepatitis B: TNF
hsa04664__3 4 5	2.45409917068369e-08	UP	5.57692426555817	6.01206302700737e-08	Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A
hsa04071__89	2.49080206725254e-08	UP	5.5743431528157	6.09403266193689e-08	Sphingolipid signaling pathway: C00533
hsa05200__186	2.51553636793199e-08	DOWN	-5.57262241098739	6.14654464934227e-08	Pathways in cancer: PTCH1*
hsa04062__8 41	2.64282710491175e-08	UP	5.56401870184583	6.44918458458334e-08	Chemokine signaling pathway: PXN PTK2B
hsa05200__48	2.87370277588579e-08	DOWN	-5.54939239630518	7.00348575342334e-08	Pathways in cancer: MTOR
hsa04950__1	3.00369721284683e-08	UP	5.54164905807778	7.30144631629385e-08	Maturity onset diabetes of the young: HNF1B
hsa04623__9	3.00373496673504e-08	UP	5.54164905807778	7.30144631629385e-08	Cytosolic DNA-sensing pathway: IKBKE
hsa04390__76	3.06334279692627e-08	DOWN	-5.53820757442116	7.4367197873701e-08	Hippo signaling pathway: MYC
hsa04520__7 68	3.17042906987713e-08	UP	5.53218497802206	7.68675641586984e-08	Adherens junction: CDH1 CTNNB1
hsa04071__69	3.18602051949144e-08	UP	5.53132460710791	7.71460380943867e-08	Sphingolipid signaling pathway: RAC1
hsa04014__79	3.29726236396317e-08	UP	5.52530201070882	7.97368852237684e-08	Ras signaling pathway: RAC1**
hsa04010__12	3.36251116561933e-08	DOWN	-5.52186052705219	8.10020317974196e-08	MAPK signaling pathway: PLA2G4B
hsa04210__71	3.36251116561933e-08	DOWN	-5.52186052705219	8.10020317974196e-08	Apoptosis: GADD45G
hsa04270__48	3.36251116561933e-08	DOWN	-5.52186052705219	8.10020317974196e-08	Vascular smooth muscle contraction: KCNMB2*
hsa05132__20	3.49678709491872e-08	UP	5.51497755973895	8.41288470083518e-08	Salmonella infection: ACTB
hsa04730__20	3.65406625017672e-08	DOWN	-5.50723422151155	8.78003898220213e-08	Long-term depression: C00025
hsa05034__84	3.95077513719169e-08	DOWN	-5.49346828688505	9.48085119129398e-08	Alcoholism: FOSB
hsa04950__20	3.98946742779427e-08	DOWN	-5.49174754505674	9.56149145003244e-08	Maturity onset diabetes of the young: NKX6-1
hsa05152__20	4.04818699441087e-08	UP	5.48916643231427	9.68986415604845e-08	Tuberculosis: FCGR1A
hsa04360__59	4.2707898873954e-08	DOWN	-5.47970235225856	1.02096872753384e-07	Axon guidance: MAPK1*
hsa05145__11	4.29160426275087e-08	UP	5.4788419813444	1.02464096692616e-07	Toxoplasmosis: MAPK14
hsa04066__59	4.37584965891203e-08	UP	5.47540049768778	1.04342912551976e-07	HIF-1 signaling pathway: NOS2
hsa04922__70	4.61587572838975e-08	DOWN	-5.46593641763207	1.09926875711589e-07	Glucagon signaling pathway: PFKFB1
hsa04210__62	4.72915228893344e-08	DOWN	-5.46163456306129	1.12339786989961e-07	Apoptosis: TP53AIP1
hsa05200__205	4.72915228893344e-08	UP	5.46163456306129	1.12339786989961e-07	Pathways in cancer: SLC2A1
hsa04261__34	4.93987730497295e-08	DOWN	-5.45389122483388	1.17197341616719e-07	Adrenergic signaling in cardiomyocytes: AKT3
hsa05213__11	4.96384545444228e-08	DOWN	-5.45303085391973	1.17617472999963e-07	Endometrial cancer: FOXO3
hsa05152__69	5.15969132478664e-08	UP	5.44614788660648	1.22104030217558e-07	Tuberculosis: HLA-DMA
hsa04728__68	5.26040229676047e-08	DOWN	-5.44270640294986	1.24330766234125e-07	Dopaminergic synapse: CACNA1C
hsa05032__25	5.33718316139958e-08	DOWN	-5.44012529020739	1.25987024626505e-07	Morphine addiction: C00575*
hsa05215__43	5.52044380047566e-08	DOWN	-5.4341026938083	1.30149484329909e-07	Prostate cancer: C05981
hsa04630__35	5.60104376331063e-08	DOWN	-5.43152158106583	1.31884225955648e-07	Jak-STAT signaling pathway: MTOR
hsa05014__54	5.62811462657481e-08	UP	5.43066121015168	1.32355787025458e-07	Amyotrophic lateral sclerosis (ALS): PPP3CA
hsa05150__40	5.82119255411744e-08	UP	5.42463861375258	1.36725260114833e-07	Staphylococcus aureus infection: FCGR1A
hsa05031__97	6.0497158465805e-08	DOWN	-5.41775564643934	1.41915306813043e-07	Amphetamine addiction: ARC
hsa04010__58	6.25678477363573e-08	UP	5.41173305004025	1.4658975797583e-07	MAPK signaling pathway: CDC25B
hsa04728__44	6.82127521949167e-08	DOWN	-5.39624637358544	1.59616141188354e-07	Dopaminergic synapse: FOS
hsa04920__26	7.29412942874522e-08	DOWN	-5.38420118078726	1.70468522345924e-07	Adipocytokine signaling pathway: NPY
hsa04380__69	7.36421976590637e-08	UP	5.38248043895895	1.71892781865069e-07	Osteoclast differentiation: NFKB2
hsa04925__33	7.65116122720264e-08	DOWN	-5.3755974716457	1.78368882703645e-07	Aldosterone synthesis and secretion: CYP11B2
hsa05030__77	8.14068105253127e-08	DOWN	-5.36441264976168	1.89545721161168e-07	Cocaine addiction: BDNF
hsa04923__26 27	8.49709499232766e-08	DOWN	-5.35666931153427	1.97599523398313e-07	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5
hsa04971__39	8.99615826246202e-08	DOWN	-5.3463448605644	2.08946617740002e-07	Gastric acid secretion: EZR
hsa04932__56	9.21232528642254e-08	UP	5.34204300599362	2.13439694367299e-07	Non-alcoholic fatty liver disease (NAFLD): CASP7
hsa05014__51	9.21232528642254e-08	UP	5.34204300599362	2.13439694367299e-07	Amyotrophic lateral sclerosis (ALS): DERL1
hsa05160__8	9.25615809461798e-08	DOWN	-5.34118263507947	2.14191146056492e-07	Hepatitis C: NFKB1
hsa05220__21	9.79815745959024e-08	DOWN	-5.3308581841096	2.26454340302215e-07	Chronic myeloid leukemia: NFKBIA
hsa03320__41	1.00329467468961e-07	UP	5.32655632953882	2.31595908322085e-07	PPAR signaling pathway: ANGPTL4
hsa04010__88 92	1.11849711134162e-07	DOWN	-5.30676779851323	2.57871910700724e-07	MAPK signaling pathway: ECSIT TRAF6
hsa04662__10	1.15059485371541e-07	UP	5.3016055730283	2.6494702575138e-07	B cell receptor signaling pathway: GSK3B
hsa04620__20	1.15603041940592e-07	UP	5.30074520211414	2.65547818834196e-07	Toll-like receptor signaling pathway: IFNB1*
hsa04670__86	1.15603041940592e-07	UP	5.30074520211414	2.65547818834196e-07	Leukocyte transendothelial migration: ACTB
hsa05162__27 28	1.31872426959124e-07	UP	5.27665481651778	3.02549804952618e-07	Measles: STAT1 IRF9
hsa04970__28	1.39503728692179e-07	UP	5.26633036554791	3.19667690503176e-07	Salivary secretion: AQP5
hsa04620__21	1.57532722807834e-07	UP	5.24396072177986	3.60540787035225e-07	Toll-like receptor signaling pathway: IFNA1
hsa04360__122	1.61249123855027e-07	DOWN	-5.23965886720908	3.68597449785397e-07	Axon guidance: CFL1**
hsa04360__96	1.658207887333e-07	DOWN	-5.23449664172414	3.78587195662055e-07	Axon guidance: GSK3B
hsa04917__46	1.73720095371058e-07	DOWN	-5.22589293258258	3.96140848546381e-07	Prolactin signaling pathway: GCK
hsa05166__33	1.74216853351125e-07	UP	5.00993983312947	3.96792081753654e-07	HTLV-I infection: HLA-A
hsa05142__49	1.87121183504404e-07	DOWN	-5.21212699795609	4.25666711628056e-07	Chagas disease (American trypanosomiasis): ADCY1
hsa05162__105	1.94191171950521e-07	UP	5.20524403064284	4.41215492255173e-07	Measles: GSK3B
hsa04068__48	1.95092869328696e-07	DOWN	-5.20438365972869	4.42728866507994e-07	FoxO signaling pathway: FASLG
hsa04922__24	1.98731078214487e-07	UP	5.20094217607207	4.50441129028975e-07	Glucagon signaling pathway: PFKL
hsa04210__119	2.0528247531103e-07	DOWN	-5.19491957967297	4.64729844710152e-07	Apoptosis: BCL2*
hsa04024__21	2.43470750428528e-07	UP	5.16308585584921	5.50519302112158e-07	cAMP signaling pathway: AKT3
hsa05215__30	2.47988481360389e-07	UP	5.15964437219259	5.60060524610783e-07	Prostate cancer: TP53
hsa04210__86	2.74320557465019e-07	DOWN	-5.14071621208116	6.18785507174996e-07	Apoptosis: BCL2L11
hsa04919__21 53	2.79389883228507e-07	DOWN	-5.13727472842453	6.29464736914107e-07	Thyroid hormone signaling pathway: THRA C02465
hsa05161__130	2.80671281748207e-07	DOWN	-5.13641435751038	6.31594417251354e-07	Hepatitis B: FASLG*
hsa04151__36	2.87163881896462e-07	DOWN	-5.1321125029396	6.45431739334273e-07	PI3K-Akt signaling pathway: PCK1
hsa04010__54	2.93801404597276e-07	DOWN	-5.12781064836882	6.59561337202248e-07	MAPK signaling pathway: NR4A1
hsa05222__35	3.07523718538416e-07	UP	5.11920693922726	6.89543039539002e-07	Small cell lung cancer: NOS2
hsa04931__40	3.13184167397376e-07	DOWN	-5.11576545557064	7.01398153205804e-07	Insulin resistance: PRKCZ
hsa04010__134	3.38383551042875e-07	DOWN	-5.10113915002999	7.5693177667805e-07	MAPK signaling pathway: ATF4*
hsa05211__4	3.54109417791188e-07	UP	5.09253544088843	7.91167177205281e-07	Renal cell carcinoma: SLC2A1
hsa04010__119	3.57338153167417e-07	DOWN	-5.09081469906012	7.9648682064244e-07	MAPK signaling pathway: NFATC3
hsa04210__63	3.57338153167417e-07	UP	5.09081469906012	7.9648682064244e-07	Apoptosis: FAS*
hsa04930__9	3.62232578437065e-07	UP	5.08823358631765	8.06439591093893e-07	Type II diabetes mellitus: C00238
hsa05152__97	3.65534791479889e-07	UP	5.08651284448934	8.128282522967e-07	Tuberculosis: IL18
hsa04015__96	3.75610431033516e-07	UP	5.0813506190044	8.34245862780114e-07	Rap1 signaling pathway: PLCE1
hsa05120__19	3.8770425046976e-07	UP	5.07532802260531	8.59075809708347e-07	Epithelial cell signaling in Helicobacter pylori infection: CXCL1
hsa05134__10	3.8770425046976e-07	DOWN	-5.07532802260531	8.59075809708347e-07	Legionellosis: NFKB1
hsa04015__95	3.93001571649445e-07	UP	5.07274690986285	8.69787930658784e-07	Rap1 signaling pathway: THBS1
hsa04024__108	4.13029097708806e-07	UP	5.06328282980713	9.13037264229232e-07	cAMP signaling pathway: AMH
hsa04950__7	4.22454736174718e-07	UP	5.05898097523635	9.32776086101404e-07	Maturity onset diabetes of the young: FOXA3
hsa04666__29	4.34039601966137e-07	UP	5.05381874975142	9.57230530627197e-07	Fc gamma R-mediated phagocytosis: WAS
hsa05142__53	4.51993421140405e-07	DOWN	-5.04607541152401	9.95657254774702e-07	Chagas disease (American trypanosomiasis): AKT3
hsa05216__14	4.54031955033005e-07	UP	5.04521504060986	9.98976631741237e-07	Thyroid cancer: MAPK1*
hsa04727__47	4.64358376496041e-07	DOWN	-5.04091318603908	1.02050220986674e-06	GABAergic synapse: CACNA1A*
hsa04921__48	4.68552060496387e-07	UP	5.03919244421077	1.02851556270176e-06	Oxytocin signaling pathway: PRKAG2
hsa04012__43	4.74911155023009e-07	UP	5.0366113314683	1.04125794666072e-06	ErbB signaling pathway: PTK2
hsa04340__17	5.1025725170669e-07	UP	5.02284539684181	1.11615061228972e-06	Hedgehog signaling pathway: SMO
hsa05205__34	5.1025725170669e-07	UP	5.02284539684181	1.11615061228972e-06	Proteoglycans in cancer: SLC9A1
hsa05219__12	5.19482295587372e-07	DOWN	-5.01940391318518	1.13500841094032e-06	Bladder cancer: ERBB2
hsa04024__25	5.24155275647144e-07	UP	5.01768317135687	1.14388822641229e-06	cAMP signaling pathway: CFTR
hsa04728__54	5.4325480736728e-07	UP	5.01080020404362	1.18419464390153e-06	Dopaminergic synapse: CAMK2A
hsa04924__58	5.60515872115097e-07	UP	5.00477760764453	1.21899227280586e-06	Renin secretion: PPP3CA
hsa05031__59	5.60515872115097e-07	UP	5.00477760764453	1.21899227280586e-06	Amphetamine addiction: PPP3CA
hsa05210__39	5.68074256609401e-07	DOWN	-5.00219649490207	1.23400176666944e-06	Colorectal cancer: BAD
hsa04728__60	5.73167666662536e-07	DOWN	-5.00047575307375	1.24362822824354e-06	Dopaminergic synapse: CACNA1A
hsa04622__44	5.78305088384854e-07	DOWN	-4.99875501124544	1.25188394133081e-06	RIG-I-like receptor signaling pathway: MAPK8
hsa05222__39	5.78305088384854e-07	UP	4.99875501124544	1.25188394133081e-06	Small cell lung cancer: BCL2L1
hsa04012__37 7	6.10074504809798e-07	UP	4.98843056027557	1.31913693272452e-06	ErbB signaling pathway: ERBB3 ERBB3
hsa04970__18	6.15530390311306e-07	DOWN	-4.98670981844726	1.32940414183327e-06	Salivary secretion: VAMP2
hsa04650__116	6.34998778620982e-07	UP	4.98068722204817	1.36987681403998e-06	Natural killer cell mediated cytotoxicity: FCGR3A
hsa04810__29	6.5797522116771e-07	UP	4.97380425473492	1.41781587221804e-06	Regulation of actin cytoskeleton: ACTN4
hsa04072__3	6.66796255743645e-07	UP	4.97122314199246	1.43517773716187e-06	Phospholipase D signaling pathway: MAPK1
hsa04024__107 64	6.81751797063168e-07	UP	4.96692128742168	1.4656883600477e-06	cAMP signaling pathway: NFKBIA NFKB1
hsa05162__27 70	7.44871122657027e-07	UP	4.94971386913856	1.59955753082577e-06	Measles: STAT1 GNB2L1
hsa04726__72	7.68264848854947e-07	UP	4.94369127273947	1.64791056050051e-06	Serotonergic synapse: KCNJ3
hsa04924__30	7.78505958162794e-07	DOWN	-4.941110159997	1.66797342689611e-06	Renin secretion: PDE3A
hsa04971__56	7.92365504652742e-07	UP	4.93766867634038	1.69573437726937e-06	Gastric acid secretion: CAMK2A
hsa04064__116	8.35384837654911e-07	DOWN	-4.92734422537051	1.78576576786528e-06	NF-kappa B signaling pathway: GADD45B
hsa04923__66	8.46486145366098e-07	DOWN	-4.92476311262804	1.80538872547435e-06	Regulation of lipolysis in adipocytes: LIPE
hsa05160__55	8.46486145366098e-07	UP	4.92476311262804	1.80538872547435e-06	Hepatitis C: MAPK14
hsa05164__77	9.28270230190211e-07	DOWN	-4.90669532343077	1.97757342690182e-06	Influenza A: CASP9
hsa04727__35	9.32348692118311e-07	DOWN	-4.90583495251661	1.98401267552696e-06	GABAergic synapse: PRKACA
hsa04919__32	9.61384842426996e-07	DOWN	-4.89981235611752	2.04348655986462e-06	Thyroid hormone signaling pathway: PLN
hsa04666__27	9.69839518116937e-07	UP	4.89809161428921	2.05912819722229e-06	Fc gamma R-mediated phagocytosis: ARPC5
hsa04270__10 3 71	9.7836574759631e-07	DOWN	-4.8963708724609	2.0748862750942e-06	Vascular smooth muscle contraction: ACTA2 MYL9 MYH11
hsa04666__30 44	9.91290525398475e-07	UP	4.89378975971843	2.09992660340895e-06	Fc gamma R-mediated phagocytosis: C04637 GSN
hsa04726__71	1.02656518398477e-06	DOWN	-4.88690679240518	2.17220268097677e-06	Serotonergic synapse: CACNA1A
hsa04210__10	1.03557085522999e-06	DOWN	-4.88518605057687	2.18879374238149e-06	Apoptosis: BIRC2
hsa04920__6	1.04465254178133e-06	DOWN	-4.88346530874856	2.20550800674957e-06	Adipocytokine signaling pathway: PTPN11
hsa04725__25	1.0538108581534e-06	DOWN	-4.88174456692025	2.22234635518546e-06	Cholinergic synapse: CACNA1A
hsa04068__14	1.08175180248872e-06	DOWN	-4.87658234143531	2.27871259739496e-06	FoxO signaling pathway: G6PC
hsa05168__92 93	1.08647740871042e-06	UP	4.87572197052116	2.28610420041084e-06	Herpes simplex infection: IRF9 STAT1
hsa04024__34	1.0912228783963e-06	UP	4.874861599607	2.29352101622668e-06	cAMP signaling pathway: ATP2B1
hsa05160__53	1.11040499570381e-06	DOWN	-4.87142011595038	2.32862833362439e-06	Hepatitis C: EIF2S1
hsa05162__74	1.11040499570381e-06	DOWN	-4.87142011595038	2.32862833362439e-06	Measles: EIF2S1
hsa04810__26 80	1.14475712439571e-06	UP	4.86539751955129	2.39799179123694e-06	Regulation of actin cytoskeleton: PFN3 ACTB
hsa04921__11	1.15979046131831e-06	UP	4.86281640680882	2.42677759111036e-06	Oxytocin signaling pathway: PRKACA
hsa04961__12	1.17501366096293e-06	UP	4.86023529406635	2.45589618348091e-06	Endocrine and other factor-regulated calcium reabsorption: SLC8A1
hsa04724__68	1.23785138763138e-06	DOWN	-4.84991084309648	2.58435861928818e-06	Glutamatergic synapse: MAPK1
hsa04913__40	1.31525067852519e-06	DOWN	-4.8378656502983	2.74290346831169e-06	Ovarian steroidogenesis: HSD17B1
hsa04062__60	1.32095382578054e-06	UP	4.83700527938414	2.75174305836101e-06	Chemokine signaling pathway: GSK3A
hsa04950__31	1.3556754586401e-06	DOWN	-4.83184305389921	2.82094594328323e-06	Maturity onset diabetes of the young: NKX6-1*
hsa05211__42	1.40333864145071e-06	UP	4.82496008658596	2.91689525142243e-06	Renal cell carcinoma: SLC2A1*
hsa04390__17 51	1.6526212841898e-06	UP	4.79226599184804	3.43124352816865e-06	Hippo signaling pathway: YWHAQ YAP1
hsa04630__27	1.67401899625447e-06	UP	4.78968487910557	3.47183409929598e-06	Jak-STAT signaling pathway: PIM1
hsa04919__49	1.87095065393834e-06	DOWN	-4.76731523533752	3.8759826667587e-06	Thyroid hormone signaling pathway: ACTB
hsa04724__36	1.88699815681323e-06	DOWN	-4.76559449350921	3.9049223971939e-06	Glutamatergic synapse: TRPC1
hsa05321__55	1.9113035743154e-06	DOWN	-4.76301338076674	3.95086844459696e-06	Inflammatory bowel disease (IBD): IL4*
hsa04024__44 67	1.92767398116589e-06	UP	4.76129263893843	3.98032902264913e-06	cAMP signaling pathway: CREB3 CREBBP
hsa04650__40	2.07236750515036e-06	UP	4.74666633339778	4.27440015606753e-06	Natural killer cell mediated cytotoxicity: TNFRSF10D
hsa05161__66 67	2.20865321637988e-06	DOWN	-4.73376076968544	4.55050372102827e-06	Hepatitis B: NFKB1 NFKBIA
hsa04920__1	2.27516038222177e-06	DOWN	-4.72773817328635	4.68239469681785e-06	Adipocytokine signaling pathway: C00195
hsa04920__9	2.43447454020075e-06	UP	4.71397223865986	5.00478956349805e-06	Adipocytokine signaling pathway: G6PC
hsa04976__38	2.49693402394839e-06	DOWN	-4.70881001317492	5.12758364043609e-06	Bile secretion: ABCC2
hsa04925__34	2.53942687600864e-06	DOWN	-4.7053685295183	5.20915185591728e-06	Aldosterone synthesis and secretion: STAR
hsa05110__12	2.63758609735507e-06	UP	4.6976251912909	5.39871925591522e-06	Vibrio cholerae infection: C00080
hsa05120__35	2.63758609735507e-06	UP	4.6976251912909	5.39871925591522e-06	Epithelial cell signaling in Helicobacter pylori infection: C00080
hsa04722__35	2.6711075748022e-06	DOWN	-4.69504407854843	5.46138316980777e-06	Neurotrophin signaling pathway: FOXO3
hsa04724__65	2.97921687984601e-06	DOWN	-4.67267443478038	6.08472664916375e-06	Glutamatergic synapse: GRM3
hsa05134__59	3.0807527079668e-06	UP	4.66579146746713	6.28527072559132e-06	Legionellosis: HSPA1A
hsa04540__10	3.33525197086862e-06	UP	4.64944442009817	6.78974913679537e-06	Gap junction: C00533
hsa04611__25	3.33525197086862e-06	UP	4.64944442009817	6.78974913679537e-06	Platelet activation: ORAI1
hsa04740__42	3.34919056184694e-06	UP	4.64858404918401	6.81074574211082e-06	Olfactory transduction: PDE2A
hsa04210__70	3.36318500675751e-06	DOWN	-4.64772367826986	6.83181040832148e-06	Apoptosis: CFLAR*
hsa05164__35	3.4197256055955e-06	UP	4.64428219461324	6.93916243295243e-06	Influenza A: IL18
hsa04660__14	3.52087185195479e-06	DOWN	-4.63825959821414	7.13669709797525e-06	T cell receptor signaling pathway: NFKB1
hsa04630__1	3.53555341297277e-06	UP	4.63739922729999	7.15873368855155e-06	Jak-STAT signaling pathway: MYC
hsa05164__36	3.62488310998502e-06	DOWN	-4.63223700181505	7.33170652708488e-06	Influenza A: IL33
hsa04510__24 69	3.71637445373844e-06	UP	4.62707477633012	7.50867483717692e-06	Focal adhesion: ZYX ACTB
hsa04390__59	3.77859415167917e-06	UP	4.6236332926735	7.61800258691541e-06	Hippo signaling pathway: SERPINE1
hsa05030__76	3.77859415167917e-06	DOWN	-4.6236332926735	7.61800258691541e-06	Cocaine addiction: PDYN
hsa05166__60	3.79430440227245e-06	DOWN	-4.62277292175934	7.63329547309415e-06	HTLV-I infection: POLD3
hsa05223__7	3.79430440227245e-06	DOWN	-4.62277292175934	7.63329547309415e-06	Non-small cell lung cancer: FOXO3
hsa04360__33 134	3.85777381585282e-06	UP	4.61933143810272	7.75268128340904e-06	Axon guidance: NCK1 PAK4
hsa04724__67	3.88988891871822e-06	DOWN	-4.6176106962744	7.80886888704225e-06	Glutamatergic synapse: PLD1
hsa04350__10	3.90604241252955e-06	DOWN	-4.61675032536025	7.82457749802029e-06	TGF-beta signaling pathway: SMAD4
hsa04726__39	3.90604241252955e-06	DOWN	-4.61675032536025	7.82457749802029e-06	Serotonergic synapse: CACNA1C
hsa04621__34 35	4.0043203930154e-06	UP	4.61158809987531	8.01290523799354e-06	NOD-like receptor signaling pathway: CASP1 PYCARD
hsa05220__4	4.20803771102621e-06	UP	4.60126364890544	8.41159878618963e-06	Chronic myeloid leukemia: PTPN11
hsa04810__31	4.31358372548089e-06	UP	4.59610142342051	8.61341532431306e-06	Regulation of actin cytoskeleton: MSN
hsa04024__110	4.49515315967259e-06	UP	4.58749771427895	8.95693826831897e-06	cAMP signaling pathway: FOS
hsa05142__18	4.49515315967259e-06	DOWN	-4.58749771427895	8.95693826831897e-06	Chagas disease (American trypanosomiasis): FOS
hsa05164__53	4.76169182753575e-06	UP	4.57545252148077	9.47798616942763e-06	Influenza A: MAPK14
hsa04915__40	4.86050237188058e-06	UP	4.57115066690999	9.66442746747472e-06	Estrogen signaling pathway: CREB3**
hsa05160__77	5.27573939272946e-06	DOWN	-4.55394324862687	1.04789791954954e-05	Hepatitis C: NFKB1*
hsa04024__118	5.38473766008871e-06	UP	4.54964139405609	1.06729135688889e-05	cAMP signaling pathway: MYL9
hsa05150__1 2 3	5.38473766008871e-06	DOWN	-4.54964139405609	1.06729135688889e-05	Staphylococcus aureus infection: CFD C3 CFB
hsa04010__15	5.56363223752559e-06	DOWN	-4.54275842674285	1.10158745777772e-05	MAPK signaling pathway: NFKB1
hsa05161__10	5.63217334164719e-06	UP	4.54017731400038	1.11398460094264e-05	Hepatitis B: CASP3
hsa05200__216	5.8904715813958e-06	DOWN	-4.53071323394466	1.16384817049871e-05	Pathways in cancer: IL6
hsa04742__67	5.93863704349935e-06	UP	4.52899249211635	1.17090230899636e-05	Taste transduction: PRKACA
hsa04930__15	5.93863704349935e-06	UP	4.52899249211635	1.17090230899636e-05	Type II diabetes mellitus: C00031*
hsa04630__33	5.96286089788722e-06	DOWN	-4.5281321212022	1.1744460825084e-05	Jak-STAT signaling pathway: RAF1
hsa04722__50	6.23564129516505e-06	DOWN	-4.51866804114648	1.22688691032619e-05	Neurotrophin signaling pathway: RHOA
hsa05164__68	6.36354271545488e-06	UP	4.5143661865757	1.25074233915688e-05	Influenza A: EIF2S1
hsa04910__26	6.65381945995498e-06	UP	4.50490210651999	1.3064291290758e-05	Insulin signaling pathway: RPS6
hsa04810__48	6.90069859542318e-06	DOWN	-4.49715876829259	1.35348775164928e-05	Regulation of actin cytoskeleton: IQGAP2
hsa04728__32	7.15632535319337e-06	DOWN	-4.48941543006518	1.40216218338377e-05	Dopaminergic synapse: CREB3
hsa04151__37	7.54160552386458e-06	DOWN	-4.47823060818116	1.47611216451474e-05	PI3K-Akt signaling pathway: G6PC
hsa04621__21 30	7.81987232131229e-06	DOWN	-4.47048726995376	1.52739501993199e-05	NOD-like receptor signaling pathway: NLRP3 PYCARD
hsa04914__34	7.81987232131229e-06	UP	4.47048726995376	1.52739501993199e-05	Progesterone-mediated oocyte maturation: MAPK14
hsa04930__13	7.88302892451999e-06	DOWN	-4.46876652812544	1.53813201964414e-05	Type II diabetes mellitus: C00162
hsa04520__44 47	7.97867895742708e-06	UP	4.46618541538298	1.55518026566447e-05	Adherens junction: ACTB TJP1
hsa05205__22	8.04306095052821e-06	UP	4.46446467355466	1.56610482135156e-05	Proteoglycans in cancer: PPP1R12A
hsa05217__22	8.10793939491554e-06	DOWN	-4.46274393172635	1.57710332536711e-05	Basal cell carcinoma: LEF1
hsa04010__14	8.17331792515538e-06	DOWN	-4.46102318989804	1.5881762545364e-05	MAPK signaling pathway: MAPT
hsa05200__5	8.40613402053947e-06	UP	4.45500059349895	1.63004394474651e-05	Pathways in cancer: CASP3*
hsa05210__7	8.40613402053947e-06	UP	4.45500059349895	1.63004394474651e-05	Colorectal cancer: CASP3*
hsa05223__21	8.43990647582861e-06	DOWN	-4.45414022258479	1.63490559464762e-05	Non-small cell lung cancer: FOXO3*
hsa04611__92	8.57629762085279e-06	DOWN	-4.45069873892817	1.65961516267584e-05	Platelet activation: RHOA*
hsa04024__111	8.6452806438125e-06	UP	4.44897799709986	1.67124303803742e-05	cAMP signaling pathway: JUN
hsa05205__150	8.89087345760021e-06	UP	4.44295540070077	1.7169528496229e-05	Proteoglycans in cancer: PRKCA
hsa04660__30	9.21655243182267e-06	DOWN	-4.43521206247337	1.77801868782287e-05	T cell receptor signaling pathway: CD40LG
hsa04520__10	9.51554776449185e-06	DOWN	-4.42832909516012	1.83381684610053e-05	Adherens junction: NLK
hsa04920__31	9.59173103422707e-06	UP	4.42660835333181	1.84660477595417e-05	Adipocytokine signaling pathway: AGRP
hsa04014__44	9.82379247128347e-06	UP	4.42144612784687	1.88934555307489e-05	Ras signaling pathway: ETS1
hsa04390__52	1.01013097332974e-05	UP	4.41542353144778	1.94073220745048e-05	Hippo signaling pathway: ITGB2
hsa04726__45	1.02631641557021e-05	DOWN	-4.41198204779116	1.96981465256019e-05	Serotonergic synapse: TRPC1
hsa04210__105	1.03451264146039e-05	DOWN	-4.41026130596285	1.98351964622865e-05	Apoptosis: ACTB
hsa04064__50	1.05107822606533e-05	DOWN	-4.40681982230622	2.01322730558282e-05	NF-kappa B signaling pathway: NFKBIA*
hsa04151__24	1.05525903038661e-05	DOWN	-4.40595945139207	2.01917690233853e-05	PI3K-Akt signaling pathway: MYC
hsa05032__38	1.16509073488057e-05	DOWN	-4.38445017853817	2.22706560614506e-05	Morphine addiction: CACNA1A
hsa04670__15	1.2508330542536e-05	UP	4.36896350208337	2.38611515267863e-05	Leukocyte transendothelial migration: PECAM1
hsa04915__30	1.25083737380971e-05	DOWN	-4.36896350208337	2.38611515267863e-05	Estrogen signaling pathway: CREB3*
hsa04921__43	1.29085044775833e-05	UP	4.36208053477012	2.45994725287819e-05	Oxytocin signaling pathway: CACNG3
hsa03320__66	1.35848811902849e-05	DOWN	-4.35089571288609	2.58360240450864e-05	PPAR signaling pathway: UCP1
hsa04917__68	1.35848811902849e-05	UP	4.35089571288609	2.58360240450864e-05	Prolactin signaling pathway: CCND1
hsa05020__62	1.41280382109345e-05	UP	4.34229200374453	2.68418440832618e-05	Prion diseases: NOTCH1
hsa05142__44	1.50403993518755e-05	UP	4.32852606911804	2.85463741234082e-05	Chagas disease (American trypanosomiasis): PLCB1
hsa05164__24	1.56999451099451e-05	UP	4.31906198906233	2.9768109850239e-05	Influenza A: IRF7
hsa04360__117	1.65149663906548e-05	UP	4.3078771671783	3.12818768629438e-05	Axon guidance: CFL1*
hsa04720__32	1.86964610664645e-05	DOWN	-4.28034529792531	3.53782984329172e-05	Long-term potentiation: ITPR1
hsa05142__7	1.91348772010886e-05	UP	4.27518307244038	3.61352295201864e-05	Chagas disease (American trypanosomiasis): C1QA
hsa04390__80	1.91349405921157e-05	DOWN	-4.27518307244038	3.61352295201864e-05	Hippo signaling pathway: BIRC2
hsa04010__79	1.96588797848737e-05	UP	4.26916047604129	3.70873846543952e-05	MAPK signaling pathway: HSPB1
hsa05120__18	2.01188177774446e-05	UP	4.26399825055635	3.79170096327165e-05	Epithelial cell signaling in Helicobacter pylori infection: CCL5
hsa04972__51	2.09082319793219e-05	DOWN	-4.25539454141479	3.9365298486118e-05	Pancreatic secretion: CLCA1
hsa04550__17	2.10696143383675e-05	DOWN	-4.25367379958648	3.9629434776569e-05	Signaling pathways regulating pluripotency of stem cells: AKT3
hsa04024__116	2.11507495478255e-05	UP	4.25281342867233	3.9742258400364e-05	cAMP signaling pathway: ACOX1
hsa05205__422	2.19786073665619e-05	DOWN	-4.24420971953077	4.12565466950748e-05	Proteoglycans in cancer: CD63
hsa04611__7	2.28372944289501e-05	UP	4.23560601038921	4.28256249820331e-05	Platelet activation: ITPR1
hsa04380__48	2.30128162032437e-05	UP	4.2338852685609	4.31117464066749e-05	Osteoclast differentiation: NFATC1
hsa05231__34	2.31896212662491e-05	UP	4.23216452673259	4.33996995610378e-05	Choline metabolism in cancer: PLD1
hsa04911__31	2.44639398525235e-05	UP	4.2201193339344	4.57390477441708e-05	Insulin secretion: CAMK2A
hsa04014__42	2.45574672989468e-05	UP	4.21925896302025	4.57772629511121e-05	Ras signaling pathway: PLA2G4B
hsa05160__22 23	2.45574672989468e-05	UP	4.21925896302025	4.57772629511121e-05	Hepatitis C: STAT1 IRF9
hsa05169__31	2.45574672989468e-05	DOWN	-4.21925896302025	4.57772629511121e-05	Epstein-Barr virus infection: MYC
hsa04360__111	2.50302294088315e-05	UP	4.21495710844947	4.66122904451877e-05	Axon guidance: RHOA***
hsa05220__15	2.54146595881017e-05	DOWN	-4.21151562479285	4.72813320455872e-05	Chronic myeloid leukemia: MYC
hsa04726__38	2.60018512101289e-05	DOWN	-4.20635339930791	4.82781407350121e-05	Serotonergic synapse: PLA2G4B
hsa05132__48	2.60018512101289e-05	DOWN	-4.20635339930791	4.82781407350121e-05	Salmonella infection: KLC3
hsa04550__67	2.67032163018169e-05	DOWN	-4.20033080290882	4.95314347789871e-05	Signaling pathways regulating pluripotency of stem cells: MYC*
hsa04750__59	2.68048679827717e-05	DOWN	-4.19947043199466	4.96709535893767e-05	Inflammatory mediator regulation of TRP channels: TRPV2
hsa04919__11	2.71120354792651e-05	DOWN	-4.1968893192522	5.01906548428957e-05	Thyroid hormone signaling pathway: CTNNB1
hsa04390__14	2.79475964190555e-05	UP	4.19000635193895	5.16865488891784e-05	Hippo signaling pathway: AREG
hsa05205__142	2.84821933768462e-05	UP	4.18570449736817	5.26234428270344e-05	Proteoglycans in cancer: CTNNB1
hsa04210__84	2.85902729610022e-05	UP	4.18484412645402	5.27712405635788e-05	Apoptosis: FAS**
hsa05205__140	2.86987423488928e-05	UP	4.18398375553986	5.29194670005589e-05	Proteoglycans in cancer: MAPK1***
hsa04068__39	2.94690544242634e-05	DOWN	-4.17796115914077	5.42866208462657e-05	FoxO signaling pathway: CCNB3
hsa05169__103	2.98051690867135e-05	DOWN	-4.1753800463983	5.4852020287889e-05	Epstein-Barr virus infection: NFKB1*
hsa04261__14 16	3.02589930333147e-05	UP	4.17193856274168	5.56327278958887e-05	Adrenergic signaling in cardiomyocytes: TNNI3 TPM1
hsa04530__22 33	3.06036625446482e-05	UP	4.16935744999921	5.6211419278e-05	Tight junction: MYL12B CGN
hsa04664__23	3.13042260526835e-05	UP	4.16419522451428	5.7442031985344e-05	Fc epsilon RI signaling pathway: AKT3
hsa05221__5	3.14224581324186e-05	DOWN	-4.16333485360012	5.76027305666484e-05	Acute myeloid leukemia: SPI1
hsa04012__47	3.22620415891496e-05	DOWN	-4.15731225720103	5.9084187276815e-05	ErbB signaling pathway: PRKCA
hsa04722__38	3.25058099704256e-05	DOWN	-4.15559151537272	5.94726552428722e-05	Neurotrophin signaling pathway: ATF4
hsa04910__14	3.2751327531252e-05	DOWN	-4.15387077354441	5.98635646218118e-05	Insulin signaling pathway: C00369
hsa04380__16	3.53053453609224e-05	UP	4.13666335526129	6.44691389049303e-05	Osteoclast differentiation: NFKB1
hsa05215__22	3.64718087632624e-05	DOWN	-3.92931396494973	6.65344938506506e-05	Prostate cancer: C16038
hsa04921__67	3.92003722647659e-05	DOWN	-4.11257296966493	7.13735460130766e-05	Oxytocin signaling pathway: RYR1
hsa04923__38	3.92003722647659e-05	DOWN	-4.11257296966493	7.13735460130766e-05	Regulation of lipolysis in adipocytes: PDE3B
hsa04062__22 41	3.94936602818689e-05	UP	4.11085222783661	7.18379357886077e-05	Chemokine signaling pathway: CRK PTK2B
hsa05134__7	3.97890300707935e-05	UP	4.1091314860083	7.23052103510842e-05	Legionellosis: IL18
hsa04340__40	3.99374999687456e-05	UP	4.10827111509415	7.25048912476067e-05	Hedgehog signaling pathway: SUFU
hsa04530__20 31	4.05366536976494e-05	UP	4.10482963143752	7.35215948821267e-05	Tight junction: ACTB MLLT4
hsa05205__415	4.27015634181218e-05	UP	4.09278443863934	7.73734210825949e-05	Proteoglycans in cancer: MAPK1******
hsa05133__60	4.43146017868555e-05	UP	4.08418072949778	8.02188215390188e-05	Pertussis: C5
hsa04662__35	4.59853219538645e-05	UP	4.07557702035622	8.31630605883651e-05	B cell receptor signaling pathway: CD79B
hsa04725__54	4.71901803220285e-05	UP	4.06955442395713	8.52599507933573e-05	Cholinergic synapse: CHRM1*
hsa04020__7	4.82466812779149e-05	UP	4.0643921984722	8.70850279742575e-05	Calcium signaling pathway: ADCY1
hsa04666__49	4.87833035422304e-05	UP	4.06181108572973	8.79691241418914e-05	Fc gamma R-mediated phagocytosis: ARF6*
hsa04666__23	4.91441899052149e-05	UP	4.06009034390142	8.85349308071896e-05	Fc gamma R-mediated phagocytosis: RPS6KB1
hsa03320__56	4.93255807394906e-05	DOWN	-4.05922997298726	8.87765959861139e-05	PPAR signaling pathway: FADS2
hsa04390__74	5.11747346819465e-05	DOWN	-4.0506262638457	9.20165803515573e-05	Hippo signaling pathway: AXIN1
hsa04068__59	5.19326360067336e-05	DOWN	-4.04718478018908	9.32900794040655e-05	FoxO signaling pathway: S1PR1
hsa04912__17	5.30894610049577e-05	UP	4.04202255470415	9.52770747166338e-05	GnRH signaling pathway: MAPK14
hsa04540__11	5.4270675032859e-05	DOWN	-4.03686032921921	9.72112472704882e-05	Gap junction: C00780
hsa04921__55	5.4270675032859e-05	UP	4.03686032921921	9.72112472704882e-05	Oxytocin signaling pathway: PTGS2*
hsa04720__4 15	5.62948761690835e-05	DOWN	-4.02825662007765	0.000100741021258769	Long-term potentiation: CREBBP ATF4
hsa05205__183	5.73335972551445e-05	UP	4.02395476550687	0.00010250221621543	Proteoglycans in cancer: VEGFA*
hsa04062__35 36 37	5.83904536349909e-05	UP	4.01965291093609	0.000104292454733981	Chemokine signaling pathway: PARD3 PRKCZ TIAM1
hsa05200__192	5.88183403864444e-05	DOWN	-4.01793216910778	0.000104956943576571	Pathways in cancer: PTGS2
hsa05132__6	5.96830379886281e-05	UP	4.01449068545116	0.000106398888406672	Salmonella infection: NFKB1
hsa04932__97	6.0119887568191e-05	DOWN	-4.01276994362285	0.000107076084114342	Non-alcoholic fatty liver disease (NAFLD): TNF*
hsa04723__10	6.05597636801173e-05	DOWN	-4.01104920179454	0.000107655436097389	Retrograde endocannabinoid signaling: CACNA1A
hsa04723__21	6.05597636801173e-05	DOWN	-4.01104920179454	0.000107655436097389	Retrograde endocannabinoid signaling: CACNA1A*
hsa04912__43	6.07808428238044e-05	UP	4.01018883088038	0.000107946317264583	GnRH signaling pathway: PTK2B
hsa05221__6	6.16728243261259e-05	DOWN	-4.00674734722376	0.000109427041462503	Acute myeloid leukemia: CEBPA
hsa05166__136 139	6.25771893410658e-05	DOWN	-4.00330586356713	0.000110926923369682	HTLV-I infection: TP53 TBPL2
hsa04668__48	6.34940989310261e-05	UP	3.99986437991051	0.000112446194054098	TNF signaling pathway: CASP3
hsa04012__3	6.41901114805844e-05	UP	3.99728326716804	0.000113571769747663	ErbB signaling pathway: ELK1
hsa04660__40 41	6.65626743778902e-05	DOWN	-3.98867955802648	0.000117658763081896	T cell receptor signaling pathway: LAT GRAP2
hsa04660__41 46	6.72904724532363e-05	DOWN	-3.98609844528402	0.00011883345652221	T cell receptor signaling pathway: GRAP2 LCP2
hsa04728__74	6.92682585014645e-05	DOWN	-3.97921547797077	0.000122211321806809	Dopaminergic synapse: GRIN2A
hsa04520__1 13	7.33899910091523e-05	DOWN	-3.96544954334428	0.000129361907229078	Adherens junction: SMAD4 SMAD2
hsa04012__48	7.66323781664631e-05	UP	3.95512509237441	0.00013495055161648	ErbB signaling pathway: CAMK2A
hsa05140__16	7.74638861403139e-05	UP	3.95254397963194	0.000136287118031507	Leishmaniasis: STAT1
hsa04210__73	7.77429459965323e-05	DOWN	-3.95168360871778	0.000136650136134223	Apoptosis: TRAF1
hsa05166__132 136	7.858583942894e-05	UP	3.94910249597531	0.000138002609613998	HTLV-I infection: CREBBP TP53
hsa04931__47	7.94373675271717e-05	DOWN	-3.94652138323285	0.000139367706427223	Insulin resistance: AKT2*
hsa04750__51	8.23386172237977e-05	UP	3.93791767409129	0.000144188501177554	Inflammatory mediator regulation of TRP channels: TRPV4
hsa04750__61	8.23386172237977e-05	UP	3.93791767409129	0.000144188501177554	Inflammatory mediator regulation of TRP channels: TRPV4*
hsa04910__17	8.41281285927961e-05	DOWN	-3.93275544860635	0.000147185059241959	Insulin signaling pathway: C00031
hsa05169__93	8.47325480260114e-05	UP	3.93103470677804	0.000148104611851977	Epstein-Barr virus infection: PLCG1
hsa05161__30	8.5341069338671e-05	DOWN	-3.92931396494973	0.000149029618296806	Hepatitis B: MYC
hsa05216__5	8.87624282388245e-05	UP	3.91984988489402	0.000154860355302462	Thyroid cancer: MAPK1
hsa04916__15	9.10066901007494e-05	DOWN	-3.91382728849493	0.000158334787684545	Melanogenesis: MITF*
hsa05161__207	9.10066901007494e-05	DOWN	-3.91382728849493	0.000158334787684545	Hepatitis B: CDK2
hsa05161__219	9.10066901007494e-05	DOWN	-3.91382728849493	0.000158334787684545	Hepatitis B: CDK2*
hsa03460__16 49	9.59975811602495e-05	UP	3.90092172478259	0.000166863510638398	Fanconi anemia pathway: FANCM C19orf40
hsa05162__58	9.80654005591751e-05	DOWN	-3.89575949929765	0.000170300265850915	Measles: STAT3
hsa05216__11	9.84140993008473e-05	DOWN	-3.8948991283835	0.000170748007928248	Thyroid cancer: MYC
hsa04014__55	0.000100887966176049	UP	3.88887653198441	0.000174878679377119	Ras signaling pathway: MLLT4
hsa04662__24	0.000103420450925438	DOWN	-3.88285393558532	0.00017910325095751	B cell receptor signaling pathway: FOS
hsa04151__105 62	0.000106764722076085	DOWN	-3.87511059735791	0.000184724597404202	PI3K-Akt signaling pathway: CCND1 CDK2
hsa04015__17	0.00011138269316858	UP	3.86478614638804	0.00019253733253336	Rap1 signaling pathway: ACTB
hsa04151__27	0.000112963441008899	DOWN	-3.86134466273142	0.000195090354462979	PI3K-Akt signaling pathway: FASLG
hsa04380__72	0.000113761727513683	UP	3.85962392090311	0.000196288600549321	Osteoclast differentiation: MAPK1
hsa04728__61	0.000121615444087726	UP	3.84327687353415	0.000209647173798932	Dopaminergic synapse: KCNJ3
hsa05221__26	0.000129073158939951	UP	3.8286505679935	0.000222299235241217	Acute myeloid leukemia: BAD
hsa05162__81	0.000130433169369404	UP	3.82606945525103	0.000224435828979038	Measles: TNFRSF10D
hsa05168__27	0.000135064709554022	UP	3.81746574610947	0.000232192670861854	Herpes simplex infection: IRF3
hsa04727__49	0.000136960209569246	DOWN	-3.81402426245285	0.000235236045503303	GABAergic synapse: GABRR3
hsa05131__12	0.000137917550686006	UP	3.81230352062454	0.000236663997935165	Shigellosis: ARPC5
hsa04810__30	0.000138398507986411	UP	3.81144314971038	0.000237272624549695	Regulation of actin cytoskeleton: VCL*
hsa04910__24	0.000138881044878489	DOWN	-3.81058277879622	0.000237882847152854	Insulin signaling pathway: ACACA
hsa04750__90	0.000143794360529953	UP	3.80197906965467	0.000246074320069018	Inflammatory mediator regulation of TRP channels: C01245**
hsa05152__24 25	0.00016231081092946	UP	3.77186608765921	0.00027750865672107	Tuberculosis: ITGB2 ITGAM
hsa04917__48	0.000168579043923618	UP	3.7624020076035	0.000287702110383722	Prolactin signaling pathway: CCND2
hsa04930__7	0.000168579043923618	DOWN	-3.7624020076035	0.000287702110383722	Type II diabetes mellitus: C00002
hsa04650__16	0.000169160031969417	DOWN	-3.76154163668934	0.000288431669755476	Natural killer cell mediated cytotoxicity: PRKCA
hsa04360__125	0.000169742903109045	UP	3.76068126577519	0.000289163114181229	Axon guidance: ENAH*
hsa04066__26	0.000179329617302525	UP	3.74691533114869	0.000305217709158918	HIF-1 signaling pathway: C01245
hsa04151__63	0.000192029410691655	DOWN	-3.72970791286558	0.000326536889311873	PI3K-Akt signaling pathway: CASP9
hsa04530__20 37	0.000194005745326138	UP	3.72712680012311	0.000329599272574877	Tight junction: ACTB TJP3
hsa05161__44	0.000196001182085146	DOWN	-3.72454568738064	0.000332688546646783	Hepatitis B: CXCL8
hsa04310__20	0.000213395961406054	DOWN	-3.70303641452674	0.000361235145479258	Wnt signaling pathway: MAPK8
hsa04390__79	0.000213395961406054	DOWN	-3.70303641452674	0.000361235145479258	Hippo signaling pathway: SNAI2
hsa05152__129	0.000213395961406054	UP	3.70303641452674	0.000361235145479258	Tuberculosis: IFNB1
hsa04370__14	0.000220005473407113	DOWN	-3.69529307629934	0.000372088464925261	VEGF signaling pathway: PTGS2
hsa05205__236	0.000222251021750333	UP	3.69271196355687	0.000375548264270572	Proteoglycans in cancer: ITGAV
hsa04919__18	0.000223759988243347	UP	3.69099122172856	0.000377758326962489	Thyroid hormone signaling pathway: STAT1
hsa05169__32	0.000228344794009734	DOWN	-3.68582899624363	0.000385152484689668	Epstein-Barr virus infection: CR2
hsa05032__37	0.000229892554767195	UP	3.68410825441532	0.000387415345657004	Morphine addiction: KCNJ3
hsa04620__86	0.000236182597600835	DOWN	-3.67722528710207	0.000397658692555528	Toll-like receptor signaling pathway: IL12A
hsa04062__44	0.000237780150293403	UP	3.67550454527376	0.000399990064817641	Chemokine signaling pathway: MAPK1
hsa04722__84	0.000240195500475506	DOWN	-3.67292343253129	0.000403691722176633	Neurotrophin signaling pathway: NFKB1*
hsa04151__110	0.000243451786741241	DOWN	-3.66948194887467	0.000408798844760314	PI3K-Akt signaling pathway: BCL2**
hsa04660__35	0.000245921129062609	DOWN	-3.6669008361322	0.000412576608489859	T cell receptor signaling pathway: NFATC1
hsa05166__34 35 36	0.000250930087769321	DOWN	-3.66173861064726	0.000420230243416391	HTLV-I infection: MYC TRRAP KAT5
hsa04933__59	0.000250930459347094	UP	3.66173861064726	0.000420230243416391	AGE-RAGE signaling pathway in diabetic complications: SERPINE1
hsa04912__33	0.000252621393231057	UP	3.66001786881895	0.000422685305326051	GnRH signaling pathway: ELK1
hsa04380__51	0.000262993509189036	UP	3.64969341784908	0.000439648401927223	Osteoclast differentiation: FOS*
hsa04612__17 28	0.00026387563668229	UP	3.64883304693493	0.000440730952289798	Antigen processing and presentation: CD4 HLA-DMA
hsa05134__73	0.000268328035665737	UP	3.64453119236415	0.000447769430742379	Legionellosis: CXCL1
hsa05150__14	0.000269225410463461	UP	3.64367082144999	0.000448472864477763	Staphylococcus aureus infection: FPR1
hsa04064__51	0.000269226924497561	DOWN	-3.64367082144999	0.000448472864477763	NF-kappa B signaling pathway: TNFAIP3
hsa03320__26	0.000277444902300332	DOWN	-3.63592748322259	0.000461752853341297	PPAR signaling pathway: CPT2
hsa04620__23	0.000286851438073376	UP	3.62732377408103	0.000476985709858295	Toll-like receptor signaling pathway: CD40
hsa04668__47	0.000300523430728078	UP	3.61527858128285	0.000499278095789619	TNF signaling pathway: CASP7
hsa04066__61	0.000320056191577254	UP	3.59893153391389	0.000530790453639595	HIF-1 signaling pathway: HMOX1
hsa04621__30 32	0.000320056191577254	DOWN	-3.59893153391389	0.000530790453639595	NOD-like receptor signaling pathway: PYCARD CASP1
hsa05162__25 70	0.000331901395555594	UP	3.58946745385817	0.000549949490519367	Measles: IFNAR1 GNB2L1
hsa04261__52	0.000346428915734156	UP	3.57828263197415	0.000573515359175753	Adrenergic signaling in cardiomyocytes: MAPK14
hsa05164__41 42	0.000347570706167656	UP	3.57742226105999	0.000574899081768508	Influenza A: STAT1 IRF9
hsa04725__61	0.000353332648432652	UP	3.57312040648921	0.000583402501234581	Cholinergic synapse: FOS
hsa04919__100	0.000353332648432652	DOWN	-3.57312040648921	0.000583402501234581	Thyroid hormone signaling pathway: CTNNB1*
hsa04064__55	0.000354495705243659	DOWN	-3.57226003557506	0.000584808981696959	NF-kappa B signaling pathway: CXCL12
hsa04931__77	0.000355651204698489	UP	3.5713996646609	0.00058620053827058	Insulin resistance: PPP2R4**
hsa04064__130	0.000362737904409749	DOWN	-3.56623743917597	0.000597357162476703	NF-kappa B signaling pathway: TNF*
hsa04390__75	0.000363929884398977	DOWN	-3.56537706826181	0.000598795317675725	Hippo signaling pathway: NKD1
hsa05169__30	0.000366324839614157	UP	3.5636563264335	0.000602208550861768	Epstein-Barr virus infection: FGR
hsa05164__70	0.000371159022004511	UP	3.56021484277687	0.000609089783708713	Influenza A: RNASEL
hsa05168__83	0.000371159022004511	UP	3.56021484277687	0.000609089783708713	Herpes simplex infection: RNASEL
hsa04066__89	0.00037852223303797	UP	3.55505261729194	0.000620631130783896	HIF-1 signaling pathway: CDKN1A
hsa04724__44	0.000382254829323125	DOWN	-3.55247150454947	0.000626204729117831	Glutamatergic synapse: PRKACA*
hsa04933__57	0.000387285152472488	DOWN	-3.54903002089285	0.000633892684229795	AGE-RAGE signaling pathway in diabetic complications: FIGF
hsa04917__40	0.000409362073511253	UP	3.5344037153522	0.000669444156769055	Prolactin signaling pathway: TH
hsa04620__22	0.000418789777415982	UP	3.52838111895311	0.000684266079795331	Toll-like receptor signaling pathway: CD86
hsa04540__12	0.000421520419870447	DOWN	-3.5266603771248	0.000688129338780687	Gap junction: C00025
hsa05140__21	0.000422891967487609	DOWN	-3.52580000621064	0.000689769103219807	Leishmaniasis: NFKB1
hsa04012__65	0.00044253643908069	DOWN	-3.51375481341246	0.000721184708614585	ErbB signaling pathway: MYC
hsa04664__46	0.000446855318669329	UP	3.51117370066999	0.000726962029246467	Fc epsilon RI signaling pathway: PLA2G4B
hsa05168__122	0.000446855318669329	UP	3.51117370066999	0.000726962029246467	Herpes simplex infection: CASP3
hsa04066__46	0.000461537367945185	DOWN	-3.50256999152843	0.000750197849800175	HIF-1 signaling pathway: ENO1
hsa04310__31	0.000466028994589738	UP	3.49998887878597	0.000756843976520413	Wnt signaling pathway: MMP7
hsa04950__18	0.000470561376767384	DOWN	-3.4974077660435	0.00076354475556642	Maturity onset diabetes of the young: SLC2A2
hsa04723__40	0.000479749767580512	DOWN	-3.49224554055856	0.000776442560967944	Retrograde endocannabinoid signaling: GRIA1
hsa04724__4	0.000479749767580512	DOWN	-3.49224554055856	0.000776442560967944	Glutamatergic synapse: GRIA1
hsa05031__12	0.000479749767580512	DOWN	-3.49224554055856	0.000776442560967944	Amphetamine addiction: GRIA1
hsa04022__58	0.000481297339784364	DOWN	-3.49138516964441	0.000778276851510173	cGMP-PKG signaling pathway: MYH7
hsa05152__15	0.000498630716442021	DOWN	-3.48192108958869	0.000805612309711572	Tuberculosis: CTSD
hsa04933__24	0.00050023500552341	DOWN	-3.48106071867454	0.000807509944483237	AGE-RAGE signaling pathway in diabetic complications: THBD
hsa05031__55	0.000505076794489022	DOWN	-3.47847960593207	0.000814626005875427	Amphetamine addiction: GRIA1*
hsa04920__10	0.000508328887995589	UP	3.47675886410376	0.000819168079368536	Adipocytokine signaling pathway: PCK1
hsa05205__91	0.000516544721136172	UP	3.47245700953298	0.000831694542429193	Proteoglycans in cancer: RAC1*
hsa04370__15	0.000526567067050686	DOWN	-3.46729478404804	0.000847105752558424	VEGF signaling pathway: PLA2G4B
hsa04380__32	0.000528254973221549	UP	3.46643441313389	0.000849094178514363	Osteoclast differentiation: AKT3
hsa04913__64	0.000535057145365686	DOWN	-3.46299292947726	0.000859292629181303	Ovarian steroidogenesis: PLA2G4B
hsa04151__109	0.00054715769483045	UP	3.45697033307817	0.000877975498365854	PI3K-Akt signaling pathway: RXRA
hsa04151__34	0.00057030916577954	DOWN	-3.44578551119415	0.000914343790528802	PI3K-Akt signaling pathway: GYS1
hsa04933__43	0.000572127312984449	UP	3.44492514027999	0.000916476744328883	AGE-RAGE signaling pathway in diabetic complications: CASP3
hsa04360__4	0.000607714265518985	DOWN	-3.42857809291103	0.000972653411337455	Axon guidance: GNAI1*
hsa04750__7	0.000641287830566002	UP	3.41395178737038	0.00102464271567476	Inflammatory mediator regulation of TRP channels: TRPV1
hsa04750__58	0.000641287830566002	UP	3.41395178737038	0.00102464271567476	Inflammatory mediator regulation of TRP channels: TRPV1**
hsa04662__29	0.000657681401923462	UP	3.40706882005713	0.0010499433765626	B cell receptor signaling pathway: RAC1
hsa04064__135	0.000659757405247866	DOWN	-3.40620844914298	0.00105236346728416	NF-kappa B signaling pathway: CCL19
hsa04068__42	0.000663927704508603	DOWN	-3.40448770731467	0.00105811718131609	FoxO signaling pathway: CDKN2D
hsa04742__27	0.000668122502990675	UP	3.40276696548636	0.001063900155186	Taste transduction: CALHM1
hsa04650__110 111	0.000713680467078351	UP	3.38469917628908	0.00113548314787487	Natural killer cell mediated cytotoxicity: ITGAL ITGB2
hsa04390__78	0.000715920274816713	DOWN	-3.38383880537493	0.00113808307646413	Hippo signaling pathway: SOX2
hsa04520__44 49	0.000740992951291839	UP	3.37437472531921	0.00117694484824798	Adherens junction: ACTB VCL
hsa04022__60	0.000747971144018529	DOWN	-3.37179361257675	0.00118702515169832	cGMP-PKG signaling pathway: TRPC6*
hsa04064__113	0.000793602853501763	DOWN	-3.35544656520778	0.00125837954576355	NF-kappa B signaling pathway: CFLAR
hsa04921__23	0.000892715177028094	UP	3.32275247046986	0.00141434385972663	Oxytocin signaling pathway: C00219
hsa05164__19	0.000909375034963929	DOWN	-3.31759024498493	0.00143952459199429	Influenza A: NFKB1
hsa04066__11	0.000914992041295838	UP	3.31586950315662	0.0014471970080765	HIF-1 signaling pathway: SLC2A1
hsa04976__41	0.000917812585294939	DOWN	-3.31500913224246	0.00145043721427182	Bile secretion: CYP7A1
hsa04020__8	0.000926322631044464	UP	3.31242801949999	0.00146265565019542	Calcium signaling pathway: PDE1A
hsa04728__36	0.000940668679777305	UP	3.30812616492921	0.00148406083064782	Dopaminergic synapse: TH
hsa04742__18	0.000972957437183558	UP	3.2986620848735	0.00153242835244586	Taste transduction: PDE1A
hsa05321__138	0.000972957437183558	DOWN	-3.2986620848735	0.00153242835244586	Inflammatory bowel disease (IBD): IFNG**
hsa05133__59	0.000997081536042849	UP	3.29177911756025	0.00156910905043929	Pertussis: C3
hsa04612__39	0.00102801530172152	DOWN	-3.28317540841869	0.0016164357756776	Antigen processing and presentation: PSME3
hsa04650__15	0.00109256420328462	DOWN	-3.26596799013558	0.00171649509863863	Natural killer cell mediated cytotoxicity: TNF
hsa05152__88 89	0.00109922093342429	UP	3.26424724830726	0.00172551055464014	Tuberculosis: ITGAX ITGB2
hsa04024__62	0.00110256367395856	DOWN	-3.26338687739311	0.00172931314137574	cAMP signaling pathway: BAD
hsa04270__24	0.00112281697799295	DOWN	-3.25822465190817	0.00175961059353524	Vascular smooth muscle contraction: ACTA2
hsa04650__36	0.00112622578202494	UP	3.25736428099402	0.00176348187035404	Natural killer cell mediated cytotoxicity: CASP3
hsa04550__22	0.00113650968408056	UP	3.25478316825155	0.00177810299449406	Signaling pathways regulating pluripotency of stem cells: SMAD2
hsa04360__35	0.00118208420332403	DOWN	-3.24359834636752	0.00184786706992167	Axon guidance: ROCK1*
hsa04010__63	0.0012036830528356	UP	3.23843612088259	0.00187850536235721	MAPK signaling pathway: MAX
hsa04740__16	0.0012036830528356	DOWN	-3.23843612088259	0.00187850536235721	Olfactory transduction: PRKG1
hsa05142__64	0.00123304879794988	UP	3.23155315356934	0.00192273750319322	Chagas disease (American trypanosomiasis): CASP8
hsa04020__64	0.00125173690247432	UP	3.22725129899856	0.00194864427485438	Calcium signaling pathway: C01330*
hsa04020__12	0.00125173690247432	UP	3.22725129899856	0.00194864427485438	Calcium signaling pathway: C01330
hsa05012__70	0.00126687530964686	DOWN	-3.22380981534194	0.00197057839969077	Parkinson's disease: PRKACA
hsa04066__44	0.00127450773289998	DOWN	-3.22208907351363	0.00198081061217458	HIF-1 signaling pathway: GAPDH
hsa05100__55	0.00130938177916846	UP	3.21434573528623	0.00203332922566739	Bacterial invasion of epithelial cells: ACTB*
hsa04914__39	0.00132913469937967	UP	3.21004388071545	0.00206229900919439	Progesterone-mediated oocyte maturation: PIK3R5
hsa04152__44	0.00133711257065465	DOWN	-3.20832313888714	0.00207296577579215	AMPK signaling pathway: SLC2A4
hsa05211__45	0.00136538432390881	UP	3.20230054248804	0.00211505123217202	Renal cell carcinoma: ETS1
hsa04024__2	0.00139005501956681	UP	3.19713831700311	0.00215149372468371	cAMP signaling pathway: CACNA1C
hsa04066__45	0.00139836950396289	DOWN	-3.1954175751748	0.00216258131518212	HIF-1 signaling pathway: ALDOA
hsa05231__50	0.00145354115432261	DOWN	-3.18423275329077	0.00224605578040476	Choline metabolism in cancer: WASF2
hsa04623__17	0.00155149905122204	DOWN	-3.16530459317934	0.00239545334202647	Cytosolic DNA-sensing pathway: NFKB1
hsa05152__81	0.00165550428513733	UP	3.14637643306791	0.00255393477157064	Tuberculosis: IFNA1
hsa05200__214	0.00168001946454558	DOWN	-3.14207457849714	0.00258962803435697	Pathways in cancer: CSF3R
hsa04068__72	0.00171993926675646	DOWN	-3.13519161118389	0.00264898842806179	FoxO signaling pathway: SMAD2
hsa04072__36	0.00186662757971606	UP	3.11110122558752	0.00287020721954703	Phospholipase D signaling pathway: MTOR
hsa04912__46	0.00186662757971606	UP	3.11110122558752	0.00287020721954703	GnRH signaling pathway: JUN
hsa04976__34	0.00193294280501385	DOWN	-3.10077677461765	0.00296974614114557	Bile secretion: SLCO1B1
hsa05200__210	0.00196120771099827	UP	3.09647492004688	0.00301071020340338	Pathways in cancer: MMP1
hsa04662__27	0.00199562581254473	DOWN	-3.09131269456194	0.00305854885952002	B cell receptor signaling pathway: NFATC1
hsa04933__63	0.00199562581254473	DOWN	-3.09131269456194	0.00305854885952002	AGE-RAGE signaling pathway in diabetic complications: SELE
hsa04917__37	0.00212662246066927	UP	3.07238453445051	0.00325666145362474	Prolactin signaling pathway: TNFSF11
hsa04722__53	0.0021327601120377	DOWN	-3.07152416353636	0.00326340085547137	Neurotrophin signaling pathway: JUN
hsa04972__39	0.00213891400224251	DOWN	-3.0706637926222	0.00327015411734229	Pancreatic secretion: KCNMA1*
hsa04015__30	0.00234464598563142	UP	3.04313192336921	0.00358178033089548	Rap1 signaling pathway: ITGAL
hsa04666__42	0.00235135776699274	DOWN	-3.04227155245506	0.00358911555172977	Fc gamma R-mediated phagocytosis: MYO10
hsa05210__22	0.00237159880646703	DOWN	-3.03969043971259	0.00361707317966847	Colorectal cancer: MYC
hsa04933__23	0.00250354035285535	DOWN	-3.02334339234363	0.00381520869668711	AGE-RAGE signaling pathway in diabetic complications: F3
hsa05010__37	0.00251781262653125	DOWN	-3.02162265051532	0.00383384921009093	Alzheimer's disease: MAPT
hsa04010__68	0.00258296343223097	DOWN	-3.01387931228791	0.00392668955433818	MAPK signaling pathway: ATF2
hsa04668__141	0.00258296343223097	UP	3.01387931228791	0.00392668955433818	TNF signaling pathway: JUN*
hsa04152__61	0.00259029677108692	UP	3.01301894137376	0.00393465451323551	AMPK signaling pathway: RPS6KB1
hsa03320__21	0.00260502058950228	DOWN	-3.01129819954545	0.00395382365724943	PPAR signaling pathway: ACAA1
hsa05130__9	0.00263469802241067	UP	3.00785671588882	0.00399563969661796	Pathogenic Escherichia coli infection: TLR4
hsa04670__18	0.002657151764091	UP	3.00527560314636	0.00402644206832821	Leukocyte transendothelial migration: CDH5
hsa05014__33 34	0.00288347521963248	UP	2.98032484663584	0.00436587424471348	Amyotrophic lateral sclerosis (ALS): NEFH PRPH
hsa04110__60 10 11 12 13 14 9	0.00315352183515737	UP	2.95279297738285	0.00477090783273808	Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6
hsa04014__58 59	0.00341795731888658	UP	2.92784222087233	0.00516680756410931	Ras signaling pathway: STK4 STK4
hsa04390__95	0.00347512691002595	UP	2.9226799953874	0.00524478993087451	Hippo signaling pathway: AFP
hsa04919__42	0.00347512691002595	UP	2.9226799953874	0.00524478993087451	Thyroid hormone signaling pathway: SLC2A1
hsa05211__48	0.00350403684012504	DOWN	-2.92009888264493	0.00528417754622388	Renal cell carcinoma: JUN
hsa04933__27	0.00352343153026821	DOWN	-2.91837814081662	0.00530916427054849	AGE-RAGE signaling pathway in diabetic complications: TNF
hsa04151__101	0.00363185905425372	UP	2.9089140607609	0.00546815958569129	PI3K-Akt signaling pathway: PKN3
hsa04213__53	0.00374331260143287	DOWN	-2.89944998070519	0.0056269475024739	Longevity regulating pathway - multiple species: SOD1
hsa04740__39	0.00374331260143287	DOWN	-2.89944998070519	0.0056269475024739	Olfactory transduction: PRKG1*
hsa05152__13	0.00382631267365915	DOWN	-2.89256701339194	0.00574711551862953	Tuberculosis: LAMP1
hsa05231__48	0.00393241293968702	UP	2.88396330425038	0.00590176031443443	Choline metabolism in cancer: WAS
hsa05020__52	0.00415266763608933	UP	2.86675588596727	0.00622734436409565	Prion diseases: FYN
hsa04014__30	0.00429013445766937	UP	2.8564314349974	0.00642835936679486	Ras signaling pathway: C01245
hsa04010__67	0.00436040385579451	UP	2.85126920951246	0.0065284452948509	MAPK signaling pathway: ELK1
hsa04921__56	0.00454066472919203	DOWN	-2.83836364580012	0.00679292119916546	Oxytocin signaling pathway: JUN
hsa04925__5	0.004639539616207	DOWN	-2.83148067848688	0.00693531816933409	Aldosterone synthesis and secretion: KCNK3
hsa04270__28	0.00471497073934129	UP	2.82631845300194	0.00704247219334045	Vascular smooth muscle contraction: KCNMB2
hsa04550__66	0.00485615025659518	DOWN	-2.81685437294623	0.00724758247191608	Signaling pathways regulating pluripotency of stem cells: MYC
hsa04066__62	0.00490842912653493	DOWN	-2.8134128892896	0.00731979232441201	HIF-1 signaling pathway: NPPA
hsa04330__11	0.00500114346715891	UP	2.80739029289051	0.00745214002759047	Notch signaling pathway: PTCRA
hsa04530__11 20 16	0.00504136070157107	UP	2.80480918014805	0.00750611470542951	Tight junction: TJP1 ACTB CTTN
hsa05166__26	0.00512267351645147	UP	2.79964695466311	0.00762114294331934	HTLV-I infection: NFATC1
hsa04151__99	0.0053595368317812	UP	2.78502064912246	0.00796722286939626	PI3K-Akt signaling pathway: MYB
hsa05142__21	0.00540234835128565	UP	2.78243953637999	0.00802451585143537	Chagas disease (American trypanosomiasis): TICAM1
hsa05200__75	0.00543106064622417	DOWN	-2.78071879455168	0.00806079222295041	Pathways in cancer: MAPK8
hsa04066__54	0.00544546839280474	UP	2.77985842363753	0.00807579724552494	HIF-1 signaling pathway: SERPINE1
hsa04919__102	0.00578651395130572	DOWN	-2.76006989261194	0.00857481050039703	Thyroid hormone signaling pathway: BMP4
hsa05205__256	0.0058017696611777	UP	2.75920952169779	0.00859064239034901	Proteoglycans in cancer: ACTB
hsa04950__16	0.00584775461146975	DOWN	-2.75662840895532	0.00865191410626116	Maturity onset diabetes of the young: PAX4
hsa04611__34	0.00586315578489245	UP	2.75576803804116	0.00866787546798813	Platelet activation: C02198*
hsa03320__43	0.00605084266629045	DOWN	-2.74544358707129	0.0089383123977671	PPAR signaling pathway: ILK
hsa04360__11	0.00614670101038757	UP	2.74028136158636	0.00907278177416987	Axon guidance: NFATC2
hsa05010__50	0.00616280969845085	DOWN	-2.7394209906722	0.00908941869967751	Alzheimer's disease: ERN1
hsa05014__31 34	0.00619514116923906	UP	2.73770024884389	0.00912993745647073	Amyotrophic lateral sclerosis (ALS): NEFL PRPH
hsa04917__34	0.0062276252847913	UP	2.73597950701558	0.00917061748442229	Prolactin signaling pathway: ELF5
hsa05169__60	0.0062602626691429	DOWN	-2.73425876518727	0.00921145932288137	Epstein-Barr virus infection: NFKB1
hsa04015__18	0.00632599975056243	UP	2.73081728153064	0.00930090260665634	Rap1 signaling pathway: CDH1
hsa04370__36	0.00634253079462076	UP	2.72995691061649	0.00931791662477906	VEGF signaling pathway: NOS3
hsa04932__96	0.00635910070589	DOWN	-2.72909653970233	0.00933496111434946	Non-alcoholic fatty liver disease (NAFLD): IL6*
hsa04064__131	0.00637570956345888	DOWN	-2.72823616878818	0.00935203612001501	NF-kappa B signaling pathway: CCL4L1
hsa04014__37	0.00656100020040646	DOWN	-2.71877208873246	0.00961631776643037	Ras signaling pathway: FASLG
hsa04064__115	0.00669878378299599	DOWN	-2.71188912141921	0.0098029709721569	NF-kappa B signaling pathway: XIAP
hsa04725__64	0.00669878378299599	UP	2.71188912141921	0.0098029709721569	Cholinergic synapse: KCNJ3
hsa05164__31 32 33	0.00723891776638483	UP	2.68607799399454	0.0105851567961378	Influenza A: NLRP3 PYCARD CASP1
hsa04152__30	0.0072950440180866	UP	2.68349688125207	0.010650650901309	AMPK signaling pathway: ACACA
hsa04350__41	0.0072950440180866	DOWN	-2.68349688125207	0.010650650901309	TGF-beta signaling pathway: SMAD4***
hsa04071__59 60	0.00756208023464467	DOWN	-2.67145168845389	0.0110319477957277	Sphingolipid signaling pathway: TP53 BCL2
hsa04932__14	0.00765955366170231	DOWN	-2.66714983388311	0.0111654781461122	Non-alcoholic fatty liver disease (NAFLD): PKLR
hsa04710__7	0.00789809961116328	DOWN	-2.65682538291324	0.0115042861778107	Circadian rhythm: PER1
hsa05150__69	0.00841655641807754	UP	2.63531611005934	0.0122499686363809	Staphylococcus aureus infection: FPR2
hsa04742__23 45	0.00845927418692717	UP	2.63359536823103	0.0123026131557555	Taste transduction: PKD1L3 PKD2L1
hsa04014__26	0.00852382844779844	DOWN	-2.63101425548856	0.0123869092447125	Ras signaling pathway: PRKCA
hsa04950__8	0.00856707842830525	DOWN	-2.62929351366025	0.0124401393870059	Maturity onset diabetes of the young: NEUROD1
hsa04071__48	0.00865413630031676	DOWN	-2.62585203000363	0.0125568510488766	Sphingolipid signaling pathway: SMPD1
hsa04064__4	0.00878628488910117	DOWN	-2.62068980451869	0.0127387571810348	NF-kappa B signaling pathway: BIRC2
hsa04933__12	0.00883072284346229	DOWN	-2.61896906269038	0.0127933139729111	AGE-RAGE signaling pathway in diabetic complications: EGR1
hsa04919__87	0.00887536147939295	UP	2.61724832086207	0.012848077210924	Thyroid hormone signaling pathway: BAD
hsa05205__451	0.00921662642688466	UP	2.60434275714973	0.0133318252933921	Proteoglycans in cancer: KDR**
hsa04022__3	0.00928626826110816	UP	2.60176164440727	0.0134222292789402	cGMP-PKG signaling pathway: MYL9
hsa04210__83	0.0096415689896019	UP	2.58885608069493	0.013925063898126	Apoptosis: TP53*
hsa04530__8	0.00966568103483803	UP	2.58799570978077	0.0139384609857718	Tight junction: LLGL2
hsa04933__21	0.00966568103483803	UP	2.58799570978077	0.0139384609857718	AGE-RAGE signaling pathway in diabetic complications: SMAD4
hsa04742__37	0.00976262847582404	UP	2.58455422612415	0.0140674684862526	Taste transduction: P2RY4
hsa04520__18	0.0098114854080199	UP	2.58283348429584	0.0141270353116241	Adherens junction: SNAI2
hsa04370__37	0.00995924650087758	DOWN	-2.5776712588109	0.014328808709915	VEGF signaling pathway: CASP9
hsa04810__8 79	0.0103630122310723	UP	2.56390532418441	0.0148869265918845	Regulation of actin cytoskeleton: ARPC5 ACTB
hsa04810__8 82	0.0103630122310723	UP	2.56390532418441	0.0148869265918845	Regulation of actin cytoskeleton: ARPC5 ACTB*
hsa04530__13 45 20	0.0105703063369456	DOWN	-2.55702235687116	0.0151615309978021	Tight junction: EPB41 TJP2 ACTB
hsa05213__13	0.0105703063369456	DOWN	-2.55702235687116	0.0151615309978021	Endometrial cancer: CASP9
hsa04064__52	0.0108079137095696	DOWN	-2.54927901864376	0.0154905185814503	NF-kappa B signaling pathway: TRAF1
hsa04931__137	0.0110230938003026	DOWN	-2.54239605133051	0.0157868850996711	Insulin resistance: MLXIP*
hsa05020__24	0.0113528230086981	UP	2.53207160036064	0.0162096918186502	Prion diseases: PRNP*
hsa05020__26	0.0113528230086981	UP	2.53207160036064	0.0162096918186502	Prion diseases: PRNP**
hsa05020__25 8	0.0113528230086981	UP	2.53207160036064	0.0162096918186502	Prion diseases: PRNP PRNP*
hsa05020__10 34	0.0113528230086981	UP	2.53207160036064	0.0162096918186502	Prion diseases: PRNP PRNP***
hsa04261__20	0.0116345925169764	DOWN	-2.52346789121908	0.0165993920572503	Adrenergic signaling in cardiomyocytes: ATP1B4
hsa05152__112	0.0120099143998015	DOWN	-2.51228306933506	0.0171218734121601	Tuberculosis: IFNGR1
hsa04068__46	0.0120392250347523	UP	2.5114226984209	0.0171506473391203	FoxO signaling pathway: PLK4
hsa05132__41	0.012098036592058	UP	2.50970195659259	0.0172213717852098	Salmonella infection: ACTB*
hsa04261__72	0.0123358369493878	DOWN	-2.50281898927934	0.0175333113675489	Adrenergic signaling in cardiomyocytes: ATP2B1
hsa05200__76	0.0123358369493878	UP	2.50281898927934	0.0175333113675489	Pathways in cancer: RAC1
hsa04915__58	0.0123658512494663	UP	2.50195861836519	0.0175626866951982	Estrogen signaling pathway: CREB3***
hsa04724__52	0.0124260739694628	DOWN	-2.50023787653688	0.0176348889642149	Glutamatergic synapse: CACNA1A
hsa04670__55	0.0125472991707427	UP	2.49679639288025	0.0177934906730759	Leukocyte transendothelial migration: RAC2
hsa04210__4	0.0126083035330362	DOWN	-2.49507565105194	0.0178665176007354	Apoptosis: DFFA
hsa04961__20	0.0132647374829888	DOWN	-2.47700786185467	0.0187825484028154	Endocrine and other factor-regulated calcium reabsorption: CALB1*
hsa05212__31	0.0132968816009901	UP	2.47614749094051	0.0188138859399552	Pancreatic cancer: RAC1*
hsa04976__36	0.0134255871425408	DOWN	-2.47270600728389	0.0189816992030355	Bile secretion: SLC10A1
hsa04152__89	0.0134903542348673	UP	2.47098526545558	0.0190589290280569	AMPK signaling pathway: CFTR
hsa04210__107	0.0136534739931111	DOWN	-2.4666834108848	0.0192748892810336	Apoptosis: MCL1
hsa04913__45	0.0137521851865794	DOWN	-2.46410229814233	0.0193851132525001	Ovarian steroidogenesis: ACOT2
hsa05134__72	0.0137521851865794	DOWN	-2.46410229814233	0.0193851132525001	Legionellosis: IL12A
hsa04931__140	0.0138515228182651	DOWN	-2.46152118539986	0.0195105032800002	Insulin resistance: G00369
hsa05205__431	0.0140857782476127	UP	2.45549858900077	0.0198256009942054	Proteoglycans in cancer: CDKN1A*
hsa04210__61	0.0143235230738572	DOWN	-2.44947599260168	0.0201451346225881	Apoptosis: APAF1
hsa04020__16	0.0143577739848214	DOWN	-2.44861562168753	0.020178202930052	Calcium signaling pathway: C06124
hsa04360__81	0.0144609605472659	UP	2.44603450894506	0.0203080305443293	Axon guidance: FYN*
hsa05210__16	0.0150581281086229	DOWN	-2.43140820340441	0.0211308608783439	Colorectal cancer: MAPK8
hsa04933__62	0.0151657361424192	DOWN	-2.42882709066194	0.0212659837400043	AGE-RAGE signaling pathway in diabetic complications: AGER**
hsa05211__40	0.0154926339783475	UP	2.42108375243454	0.0217081724424422	Renal cell carcinoma: PAK4
hsa05142__67	0.0157883992719201	DOWN	-2.41420078512129	0.0221061119463024	Chagas disease (American trypanosomiasis): IFNGR1*
hsa04010__57	0.0161270612176373	DOWN	-2.40645744689389	0.0225634758212512	MAPK signaling pathway: NLK
hsa04010__61	0.016279616042599	UP	2.40301596323727	0.0227599691547942	MAPK signaling pathway: ATF4
hsa04670__54	0.0163948629077048	UP	2.4004348504948	0.0229040501141838	Leukocyte transendothelial migration: RAC1*
hsa04666__50 52	0.0166665635716046	UP	2.39441225409571	0.0232663246293053	Fc gamma R-mediated phagocytosis: DNM2 AMPH
hsa05205__188	0.0169025885598905	DOWN	-2.38925002861077	0.0235782954001739	Proteoglycans in cancer: TNF
hsa04740__37	0.0171816545486845	UP	2.38322743221168	0.0239497988849986	Olfactory transduction: CNGB1*
hsa04713__14	0.0172218492820401	DOWN	-2.38236706129753	0.023988031727912	Circadian entrainment: PRKCA
hsa05164__47	0.0172621264728987	UP	2.38150669038337	0.024026322698205	Influenza A: CIITA
hsa05134__9	0.0176283548136067	DOWN	-2.37376335215597	0.0245178968873183	Legionellosis: CASP7
hsa04020__42	0.0177519353103835	DOWN	-2.3711822394135	0.0246532789713308	Calcium signaling pathway: MYLK4
hsa05169__45	0.0177519353103835	DOWN	-2.3711822394135	0.0246532789713308	Epstein-Barr virus infection: RB1
hsa05212__14	0.0178347434776137	UP	2.36946149758519	0.0247499874404994	Pancreatic cancer: MAPK1
hsa05152__9	0.0179178899005111	DOWN	-2.36774075575688	0.0248470222310408	Tuberculosis: TCIRG1
hsa04062__38	0.0180432462466946	UP	2.36515964301441	0.0250024039067398	Chemokine signaling pathway: NCF1
hsa04970__27	0.0188551517687714	UP	2.34881259564545	0.0261082020438625	Salivary secretion: PRKCA
hsa04742__8	0.0194288915475988	UP	2.33762777376142	0.0268828330029	Taste transduction: PLCB2
hsa04622__45	0.0194736732626286	DOWN	-2.33676740284727	0.0269249684035902	RIG-I-like receptor signaling pathway: MAPK14
hsa04370__16	0.0201559753000682	UP	2.32386183913493	0.027847851168256	VEGF signaling pathway: HSPB1
hsa05100__15	0.0206694921394449	UP	2.31439775907922	0.0285363524834805	Bacterial invasion of epithelial cells: CTNNA1
hsa04662__6	0.0208590458266034	DOWN	-2.31095627542259	0.0287769068342054	B cell receptor signaling pathway: NFKB1
hsa04740__21	0.0210501039455776	UP	2.30751479176597	0.0290191821817611	Olfactory transduction: PDE1A
hsa05205__284	0.0210981060601629	DOWN	-2.30665442085181	0.0290640332016467	Proteoglycans in cancer: PRKCA*
hsa04924__23	0.0212426850632963	DOWN	-2.30407330810934	0.029241762076142	Renin secretion: ITPR1
hsa04115__52 53	0.0213881262881278	DOWN	-2.30149219536688	0.029398894875927	p53 signaling pathway: CDK4 CCND1
hsa04530__1 5	0.0213881262881278	DOWN	-2.30149219536688	0.029398894875927	Tight junction: IGSF5 IGSF5
hsa04261__15 16	0.0219785969487365	UP	2.29116774439701	0.0301884383528332	Adrenergic signaling in cardiomyocytes: ACTC1 TPM1
hsa04810__23	0.0231500637890735	DOWN	-2.27137921337142	0.031774265785003	Regulation of actin cytoskeleton: GSN
hsa04360__145	0.0232022044174598	UP	2.27051884245727	0.0318225854747496	Axon guidance: ABLIM3
hsa04621__21 31 41	0.0233067916437366	UP	2.26879810062896	0.0319427144409781	NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1
hsa04726__41	0.0242666233825847	DOWN	-2.25331142417415	0.0332097489700485	Serotonergic synapse: HTR3C
hsa04742__57	0.0242666233825847	DOWN	-2.25331142417415	0.0332097489700485	Taste transduction: HTR3C
hsa04924__49	0.0247592811813704	UP	2.24556808594675	0.0338593081075654	Renin secretion: PDE1A
hsa04012__35	0.0248145503929445	UP	2.24470771503259	0.0339102110460674	ErbB signaling pathway: CBLC
hsa05215__34	0.0253168002144803	UP	2.23696437680519	0.0345714154091632	Prostate cancer: BAD
hsa05212__12	0.0257134985608968	DOWN	-2.2309417804061	0.0350876280289943	Pancreatic cancer: CASP9
hsa04066__30	0.0269360149306113	DOWN	-2.21287399120883	0.0367291524344112	HIF-1 signaling pathway: PDK1
hsa04151__5	0.0272343794156372	DOWN	-2.20857213663805	0.0370821731318713	PI3K-Akt signaling pathway: EIF4B
hsa04930__8	0.0272343794156372	DOWN	-2.20857213663805	0.0370821731318713	Type II diabetes mellitus: C00022
hsa04010__64	0.0274751203111315	UP	2.20513065298142	0.0373558256618061	MAPK signaling pathway: DDIT3
hsa04261__39	0.0274751203111315	UP	2.20513065298142	0.0373558256618061	Adrenergic signaling in cardiomyocytes: SCN1B
hsa04620__87	0.0280850185692849	UP	2.19652694383986	0.0381574474994117	Toll-like receptor signaling pathway: CCL4L1
hsa05145__13	0.028208388633729	DOWN	-2.19480620201155	0.0382973715627	Toxoplasmosis: GNAI1
hsa04012__31	0.029532220762204	UP	2.17673841281428	0.0400657348824414	ErbB signaling pathway: BAD
hsa04933__26	0.030050412945506	DOWN	-2.16985544550103	0.0407393404939436	AGE-RAGE signaling pathway in diabetic complications: IL6
hsa05161__194	0.0311102764472427	UP	2.15608951087454	0.0421457890730851	Hepatitis B: TNF*
hsa05200__198	0.0315159151425666	DOWN	-2.15092728538961	0.0426645565942959	Pathways in cancer: BCL2L1*
hsa05140__26	0.0316521323646948	UP	2.14920654356129	0.0428181113846376	Leishmaniasis: C00533
hsa05145__10	0.0325499092773114	DOWN	-2.13802172167727	0.0440009205266678	Toxoplasmosis: MAPK8
hsa04723__42	0.0326899467184023	UP	2.13630097984896	0.044126731238418	Retrograde endocannabinoid signaling: KCNJ3
hsa04723__50	0.0326899467184023	UP	2.13630097984896	0.044126731238418	Retrograde endocannabinoid signaling: KCNJ3*
hsa04261__36	0.0329715699532539	DOWN	-2.13285949619233	0.0444749317603475	Adrenergic signaling in cardiomyocytes: MAPK1
hsa04930__10	0.0337567655363579	DOWN	-2.12339541613662	0.0455014077782041	Type II diabetes mellitus: C00031
hsa04921__58	0.0352253951460205	DOWN	-2.1061879978535	0.0474469659350341	Oxytocin signaling pathway: MEF2C
hsa04961__13	0.0357521399075534	DOWN	-2.10016540145441	0.0481219705489204	Endocrine and other factor-regulated calcium reabsorption: ATP2B1
hsa05032__13	0.0376885536896103	UP	2.07865612860051	0.0506920489497335	Morphine addiction: PRKACA
hsa04973__36	0.0378472505697376	UP	2.0769353867722	0.0508690871391538	Carbohydrate digestion and absorption: SLC2A2
hsa04921__46	0.0384071733553994	DOWN	-2.07091279037311	0.0515847596388816	Oxytocin signaling pathway: C00942*
hsa05231__21	0.0384877342884838	DOWN	-2.07005241945896	0.0516560376629007	Choline metabolism in cancer: PCYT1A
hsa04540__21	0.0394657071197376	DOWN	-2.05972796848909	0.0529308091919965	Gap junction: C03758
hsa03320__32	0.0397963694609809	UP	2.05628648483246	0.0533362184145386	PPAR signaling pathway: FABP3
hsa04064__36	0.0401293658828101	DOWN	-2.05284500117584	0.0537441756905204	NF-kappa B signaling pathway: PLCG1
hsa05168__91 92	0.0402129833032426	UP	2.05198463026168	0.0538178031529864	Herpes simplex infection: STAT1 IRF9
hsa05321__75	0.0403806615127128	UP	2.05026388843337	0.0540037458949376	Inflammatory bowel disease (IBD): IL10
hsa04066__29	0.0416572437798256	DOWN	-2.03735832472103	0.0556713805563957	HIF-1 signaling pathway: LDHA
hsa04933__58	0.0419166188641439	DOWN	-2.03477721197857	0.05597819960606	AGE-RAGE signaling pathway in diabetic complications: CCL2
hsa05162__13	0.0424394710608548	UP	2.02961498649363	0.0566361975307856	Measles: IRF7
hsa04152__60	0.0432340862230561	UP	2.02187164826623	0.0576556763755305	AMPK signaling pathway: EEF2
hsa04810__35 81 80	0.0443130986929186	DOWN	-2.01154719729636	0.0590527038609887	Regulation of actin cytoskeleton: MYL12B MYH9 ACTB
hsa04724__33 70 69	0.0447693483385046	DOWN	-2.00724534272558	0.0596184305655919	Glutamatergic synapse: ITPR1 HOMER3 HOMER3
hsa04022__19	0.0450449952951503	UP	2.00466422998311	0.0599430213594812	cGMP-PKG signaling pathway: CNGB1
hsa04261__66	0.0451371950414881	UP	2.00380385906896	0.0600232055788791	Adrenergic signaling in cardiomyocytes: C01245
hsa04530__30	0.0465393935537802	DOWN	-1.99089829535662	0.0618440738950162	Tight junction: AKT3
hsa04071__24	0.0473981810176161	DOWN	-1.98315495712922	0.0628963150650429	Sphingolipid signaling pathway: PTEN
hsa04620__76	0.0473981810176161	UP	1.98315495712922	0.0628963150650429	Toll-like receptor signaling pathway: CCL3L3
hsa04068__43	0.0474944192222345	UP	1.98229458621506	0.0629795439086652	FoxO signaling pathway: CDKN1A
hsa05132__8	0.0485639252693176	DOWN	-1.97283050615935	0.0643523382094836	Salmonella infection: TJP1
hsa05200__49	0.0492549946172536	UP	1.96680790976025	0.0652220823719658	Pathways in cancer: CASP9
hsa04950__22	0.0495536832095666	UP	1.96422679701779	0.0655713878526588	Maturity onset diabetes of the young: NR5A2
hsa04610__46	0.0502565357869846	UP	1.9582042006187	0.0664546310652668	Complement and coagulation cascades: C2
hsa04066__48	0.0505603060040057	UP	1.95562308787623	0.066809293235954	HIF-1 signaling pathway: PFKFB3
hsa04340__20 22	0.0512750898106246	DOWN	-1.94960049147714	0.0676586332543284	Hedgehog signaling pathway: GLI1 SUFU*
hsa05218__14	0.0512750898106246	UP	1.94960049147714	0.0676586332543284	Melanoma: BAD
hsa05321__19	0.0514808608236032	DOWN	-1.94787974964883	0.0678824824474037	Inflammatory bowel disease (IBD): TNF
hsa04261__15 17	0.0518944766758666	UP	1.9444382659922	0.0683798889719168	Adrenergic signaling in cardiomyocytes: ACTC1 MYH6
hsa04723__7	0.0526249935396642	DOWN	-1.93841566959311	0.0692938772677148	Retrograde endocannabinoid signaling: ITPR1
hsa05321__94	0.0527300514848002	UP	1.93755529867896	0.0693835901540193	Inflammatory bowel disease (IBD): IL22
hsa05166__62 63	0.053897301936846	DOWN	-1.92809121862324	0.0708698602794497	HTLV-I infection: ANAPC10 CDC20
hsa04015__27	0.0543270696816326	UP	1.92464973496662	0.0713850097425088	Rap1 signaling pathway: RALA
hsa04912__14	0.0550860424380985	DOWN	-1.91862713856753	0.0723317077157142	GnRH signaling pathway: ATF4
hsa04530__5 15	0.0551951852945947	DOWN	-1.91776676765337	0.072424408637251	Tight junction: IGSF5 MPDZ
hsa04925__18	0.0554140118026651	DOWN	-1.91604602582506	0.0726608012402007	Aldosterone synthesis and secretion: PDE2A
hsa04068__40	0.0561856056738505	UP	1.91002342942597	0.0735698627603937	FoxO signaling pathway: CCND1
hsa05032__4	0.0561856056738505	DOWN	-1.91002342942597	0.0735698627603937	Morphine addiction: ADCY1
hsa04530__14 20 43	0.056966124618909	UP	1.90400083302688	0.0744880641328671	Tight junction: CTNNA1 ACTB ACTN4
hsa04670__76	0.056966124618909	UP	1.90400083302688	0.0744880641328671	Leukocyte transendothelial migration: CDC42
hsa05161__32	0.0574161713209852	DOWN	-1.90055934937026	0.0750243295633736	Hepatitis B: STAT3
hsa04620__39	0.0579828834494314	DOWN	-1.89625749479948	0.0757121876313284	Toll-like receptor signaling pathway: IL6
hsa04728__64	0.0580967818912951	UP	1.89539712388532	0.0758082313706552	Dopaminergic synapse: SCN1A
hsa05142__84	0.0582108661817156	DOWN	-1.89453675297116	0.0759043841467339	Chagas disease (American trypanosomiasis): NFKB1*
hsa04022__65	0.0591302573095376	DOWN	-1.88765378565792	0.077049759698073	cGMP-PKG signaling pathway: PDE2A
hsa04064__128	0.059710973776724	DOWN	-1.88335193108714	0.0777525431229829	NF-kappa B signaling pathway: IL1B*
hsa05200__213	0.0600616689054307	DOWN	-1.88077081834467	0.078155038693424	Pathways in cancer: CSF2RA
hsa05200__215	0.0616011401002255	DOWN	-1.86958599646064	0.0801027974036842	Pathways in cancer: CSF1R
hsa04310__33	0.0628074542527282	DOWN	-1.86098228731909	0.0816149422827637	Wnt signaling pathway: CCND1
hsa04022__66	0.0629291526150332	DOWN	-1.86012191640493	0.0817165706728731	cGMP-PKG signaling pathway: PDE3A
hsa04668__153	0.0634178970437236	UP	1.85668043274831	0.0822943567300806	TNF signaling pathway: MAPK14*
hsa05200__224	0.0691354550247372	DOWN	-1.81796374161129	0.0895900137872284	Pathways in cancer: MYC***
hsa05221__12	0.0691354550247372	DOWN	-1.81796374161129	0.0895900137872284	Acute myeloid leukemia: MYC
hsa05166__89 90	0.069399090921565	DOWN	-1.81624299978298	0.0898696704628674	HTLV-I infection: CHUK IKBKG
hsa04950__21	0.0712677436931871	DOWN	-1.8041978069848	0.0922259575754122	Maturity onset diabetes of the young: PKLR
hsa04064__132	0.0718091560663942	DOWN	-1.80075632332818	0.0928626319674843	NF-kappa B signaling pathway: VCAM1
hsa04520__73	0.0720811231852978	UP	1.79903558149987	0.0931502272800375	Adherens junction: PARD3
hsa04064__129	0.0741478725425912	DOWN	-1.78613001778753	0.0956894591397864	NF-kappa B signaling pathway: PTGS2
hsa05132__54	0.0741478725425912	UP	1.78613001778753	0.0956894591397864	Salmonella infection: IL1B
hsa04340__46	0.0747071115698294	UP	1.7826885341309	0.096344998380034	Hedgehog signaling pathway: PRKACA
hsa04970__45	0.075128727556379	UP	1.78010742138844	0.0968222764598328	Salivary secretion: KCNMA1
hsa04911__25	0.0765484756251231	DOWN	-1.77150371224688	0.0985843630566184	Insulin secretion: PRKCA
hsa04064__95	0.0771224375222957	UP	1.76806222859026	0.0992555206194477	NF-kappa B signaling pathway: BCL2L1**
hsa04062__43	0.0776999016267455	UP	1.76462074493363	0.0999302636253626	Chemokine signaling pathway: STAT1
hsa04360__114	0.0788653944171498	DOWN	-1.75773777762039	0.101359833180454	Axon guidance: RAF1
hsa05200__200	0.0796010222263075	UP	1.75343592304961	0.102235352538094	Pathways in cancer: FIGF
hsa04666__20	0.0797488150968378	DOWN	-1.75257555213545	0.10235520735448	Fc gamma R-mediated phagocytosis: PLA2G4B
hsa04310__14	0.0798968309323717	UP	1.75171518122129	0.102475184520086	Wnt signaling pathway: PRKCA
hsa04620__19	0.0806402625178655	UP	1.74741332665052	0.103358153663758	Toll-like receptor signaling pathway: CXCL10
hsa04115__43 57	0.0812390442763372	UP	1.74397184299389	0.104054644986529	p53 signaling pathway: CDK1 CCNB3
hsa04728__71 72	0.0815397856397596	UP	1.74225110116558	0.104368703826368	Dopaminergic synapse: CLOCK ARNTL
hsa04919__26	0.0822955925091944	DOWN	-1.7379492465948	0.105264410023673	Thyroid hormone signaling pathway: THRB
hsa04012__29	0.0836703535231463	UP	1.7302059083674	0.106950064129246	ErbB signaling pathway: STAT5A*
hsa05034__61	0.0839783676098365	UP	1.72848516653909	0.10727080403731	Alcoholism: CRH
hsa04620__46	0.0844421091579666	DOWN	-1.72590405379662	0.107789893415638	Toll-like receptor signaling pathway: TNF
hsa04722__70	0.085063652193095	DOWN	-1.72246257014	0.108509573978836	Neurotrophin signaling pathway: ZNF274
hsa04922__36	0.0864756538211716	DOWN	-1.71471923191259	0.110235925054261	Glucagon signaling pathway: GYS1
hsa04066__55	0.0872682415284762	UP	1.71041737734181	0.111170864970852	HIF-1 signaling pathway: ANGPT1
hsa04010__66	0.0901702138378762	UP	1.69493070088701	0.114789858944017	MAPK signaling pathway: TP53
hsa05145__4 5	0.0904973940677203	DOWN	-1.6932099590587	0.115128370652164	Toxoplasmosis: MAP3K7 TAB1
hsa04066__56	0.0908255287093439	DOWN	-1.69148921723039	0.115389566223703	HIF-1 signaling pathway: TEK
hsa05205__189	0.0908255287093439	DOWN	-1.69148921723039	0.115389566223703	Proteoglycans in cancer: IL12B
hsa04330__12	0.0911546195724215	UP	1.68976847540207	0.115729412281473	Notch signaling pathway: HES1
hsa05161__126	0.0913195241524207	UP	1.68890810448792	0.115860490129911	Hepatitis B: MYC*
hsa04750__39	0.0928144805194481	UP	1.68116476626052	0.11767773879625	Inflammatory mediator regulation of TRP channels: C01245*
hsa04916__4	0.0934851817395432	UP	1.67772328260389	0.118448183741471	Melanogenesis: TYR
hsa04742__49	0.0943290200488658	UP	1.67342142803311	0.119436811773463	Taste transduction: HTR1A
hsa04370__23	0.0950084777229384	DOWN	-1.66997994437649	0.120216114236634	VEGF signaling pathway: PTK2
hsa04911__24	0.0955206395478297	DOWN	-1.66739883163402	0.120782827530533	Insulin secretion: INS
hsa04390__60	0.0974175064860034	DOWN	-1.65793475157831	0.123098516938265	Hippo signaling pathway: CTGF*
hsa03320__63	0.0977656046916771	UP	1.65621400975	0.123455356999772	PPAR signaling pathway: DBI
hsa04912__19	0.0986401994187421	UP	1.65191215517922	0.124476114645948	GnRH signaling pathway: MAPK7
hsa04933__52	0.098991781711008	DOWN	-1.65019141335091	0.124806814103415	AGE-RAGE signaling pathway in diabetic complications: FOXO1
hsa04261__8 38	0.0991679475552947	DOWN	-1.64933104243675	0.124806814103415	Adrenergic signaling in cardiomyocytes: ATP2A2 PLN
hsa05200__225	0.0991679475552947	UP	1.64933104243675	0.124806814103415	Pathways in cancer: PPARD
hsa05221__11	0.0991679475552947	UP	1.64933104243675	0.124806814103415	Acute myeloid leukemia: PPARD
hsa05231__38	0.101301509429138	DOWN	-1.63900659146688	0.127406650747892	Choline metabolism in cancer: RPS6KB1
hsa04066__64	0.102925547894267	DOWN	-1.63126325323948	0.129276139367197	HIF-1 signaling pathway: LTBR
hsa04340__51	0.102925547894267	DOWN	-1.63126325323948	0.129276139367197	Hedgehog signaling pathway: CCND1*
hsa04933__22	0.104570224801289	UP	1.62351991501207	0.131254143220857	AGE-RAGE signaling pathway in diabetic complications: EDN1
hsa04666__40	0.104754247716951	DOWN	-1.62265954409792	0.131397350774466	Fc gamma R-mediated phagocytosis: PLA2G6
hsa04726__16	0.106422046689832	DOWN	-1.61491620587052	0.133311350486797	Serotonergic synapse: ITPR1
hsa04726__46	0.106422046689832	DOWN	-1.61491620587052	0.133311350486797	Serotonergic synapse: ITPR1*
hsa04210__57	0.109629707978743	UP	1.60028990032987	0.137237988868792	Apoptosis: BAK1
hsa05166__83	0.110587542149773	UP	1.59598804575909	0.138344867975648	HTLV-I infection: NFKB2
hsa05215__9	0.111551973362927	DOWN	-1.59168619118831	0.139458521589447	Prostate cancer: CDKN1B
hsa04510__43	0.111745653668653	DOWN	-1.59082582027415	0.139515005477341	Focal adhesion: BAD
hsa04650__39	0.111745653668653	UP	1.59082582027415	0.139515005477341	Natural killer cell mediated cytotoxicity: FAS
hsa04015__67	0.112718037582984	UP	1.58652396570337	0.140542264511232	Rap1 signaling pathway: AKT3
hsa05220__50	0.112718037582984	DOWN	-1.58652396570337	0.140542264511232	Chronic myeloid leukemia: MAPK1
hsa04742__47	0.113304661728921	UP	1.58394285296091	0.141086454200559	Taste transduction: GABRA1
hsa05162__78	0.113304661728921	UP	1.58394285296091	0.141086454200559	Measles: FAS
hsa05134__69	0.113500736723828	UP	1.58308248204675	0.141237009472896	Legionellosis: IL1B*
hsa04530__6 11 45	0.113893688444815	UP	1.58136174021844	0.141632190991268	Tight junction: CLDN24 TJP1 TJP2
hsa04723__67	0.115078973177222	UP	1.5761995147335	0.143011501719577	Retrograde endocannabinoid signaling: PRKACA
hsa05152__77	0.11607410364541	DOWN	-1.57189766016272	0.144057622688062	Tuberculosis: IL12A
hsa05231__17	0.11607410364541	DOWN	-1.57189766016272	0.144057622688062	Choline metabolism in cancer: SLC44A3
hsa05162__20	0.118084641958102	UP	1.56329395102116	0.146456133491269	Measles: NFKB1
hsa05169__11	0.118168075001952	UP	1.48155871417636	0.146462937288039	Epstein-Barr virus infection: HLA-A
hsa04012__57	0.119712658456219	DOWN	-1.55641098370792	0.14827955520055	ErbB signaling pathway: ABL1
hsa04662__32 51	0.121151548637109	UP	1.55038838730883	0.14986422639179	B cell receptor signaling pathway: BLNK GRB2
hsa04740__10	0.121151548637109	UP	1.55038838730883	0.14986422639179	Olfactory transduction: ANO2
hsa05161__214	0.121979825665177	UP	1.5469469036522	0.150789534490045	Hepatitis B: CDKN1B
hsa04666__38	0.122395620860102	UP	1.54522616182389	0.151204057591145	Fc gamma R-mediated phagocytosis: CFL1
hsa04024__91	0.122603933376295	UP	1.54436579090974	0.151361886211602	cAMP signaling pathway: GRIA1
hsa05321__83	0.123021389314036	DOWN	-1.54264504908142	0.151777538096569	Inflammatory bowel disease (IBD): IL2
hsa05168__29	0.12428041972255	UP	1.53748282359649	0.153230255025375	Herpes simplex infection: IKBKG
hsa04012__25	0.125761968094475	DOWN	-1.5314602271974	0.154853694658924	ErbB signaling pathway: CDKN1B
hsa04210__50	0.125761968094475	DOWN	-1.5314602271974	0.154853694658924	Apoptosis: SPTA1
hsa04010__86	0.125974736509441	DOWN	-1.53059985628324	0.155014099476908	MAPK signaling pathway: MAP4K2
hsa04024__92	0.126828615251406	DOWN	-1.52715837262662	0.15596267543023	cAMP signaling pathway: GRIN3A
hsa04530__4 45	0.128117871816583	DOWN	-1.52199614714168	0.157445049799451	Tight junction: OCLN TJP2
hsa04530__4 53	0.128549880995169	DOWN	-1.52027540531337	0.157872696986877	Tight junction: OCLN OCLN
hsa05223__24	0.128766309715337	UP	1.51941503439922	0.158035203105891	Non-small cell lung cancer: STK4
hsa04630__7	0.128983021469008	DOWN	-1.51855466348506	0.158197844216884	Jak-STAT signaling pathway: BCL2
hsa04919__29	0.129200016465688	DOWN	-1.51769429257091	0.158360620312477	Thyroid hormone signaling pathway: HIF1A
hsa04950__11	0.130946198279972	DOWN	-1.51081132525766	0.16039628850591	Maturity onset diabetes of the young: HNF4G
hsa04919__39	0.132267803908424	UP	1.50564909977272	0.16190957885598	Thyroid hormone signaling pathway: ESR1
hsa03320__46	0.132932469886041	UP	1.50306798703026	0.162617259710853	PPAR signaling pathway: APOA2
hsa04933__35	0.133377015135783	UP	1.50134724520194	0.16294890210672	AGE-RAGE signaling pathway in diabetic complications: CCND1
hsa05200__197	0.133377015135783	UP	1.50134724520194	0.16294890210672	Pathways in cancer: CCND1**
hsa05223__8	0.134045989038305	DOWN	-1.49876613245948	0.163659787786209	Non-small cell lung cancer: CASP9
hsa04918__14	0.134269556104674	DOWN	-1.49790576154532	0.163826296052391	Thyroid hormone synthesis: DUOX2
hsa04921__28	0.134941987481934	DOWN	-1.49532464880285	0.164539905566874	Oxytocin signaling pathway: EEF2
hsa04933__65	0.138343248588403	DOWN	-1.48241908509052	0.16857779772867	AGE-RAGE signaling pathway in diabetic complications: COL1A1
hsa05200__190	0.138572326956605	DOWN	-1.48155871417636	0.168747506384615	Pathways in cancer: MYC*
hsa04611__43	0.138801697429992	UP	1.4806983432622	0.168917350693624	Platelet activation: MYL12B
hsa04071__11	0.140647201262923	DOWN	-1.47381537594896	0.171052486196138	Sphingolipid signaling pathway: PRKCA
hsa04360__21	0.142745883075714	DOWN	-1.46607203772155	0.173492570698102	Axon guidance: PAK4
hsa04014__35	0.143215504630134	DOWN	-1.46435129589324	0.17395082947642	Ras signaling pathway: NFKB1
hsa04971__55	0.146058163618138	DOWN	-1.45402684492337	0.177288946665685	Gastric acid secretion: MYLK4
hsa05214__23	0.146775531165186	DOWN	-1.45144573218091	0.177929821328635	Glioma: MAPK1
hsa05214__56	0.146775531165186	DOWN	-1.45144573218091	0.177929821328635	Glioma: MAPK1*
hsa05200__65	0.149671971580257	UP	1.44112128121104	0.181324071308384	Pathways in cancer: STK4
hsa05132__86	0.152365163268322	UP	1.43165720115532	0.184467874859006	Salmonella infection: MYH9
hsa04972__42	0.155345087301305	DOWN	-1.42133275018545	0.187954551860368	Pancreatic secretion: CFTR
hsa04670__73	0.156096936434085	UP	1.41875163744298	0.188742692123324	Leukocyte transendothelial migration: MYL12B*
hsa03320__47	0.159131958024767	DOWN	-1.40842718647311	0.19228871326594	PPAR signaling pathway: PLTP
hsa05162__28 34	0.159386878108594	DOWN	-1.40756681555896	0.192472971700545	Measles: IRF9 STAT1
hsa05152__78	0.161695077377722	UP	1.39982347733155	0.195134907124431	Tuberculosis: IL1A
hsa04919__46	0.161953093837922	DOWN	-1.3989631064174	0.195320836534952	Thyroid hormone signaling pathway: ATP1B4
hsa04210__85	0.162470058881767	DOWN	-1.39724236458909	0.195818627734984	Apoptosis: FASLG*
hsa05205__220	0.16324783949092	DOWN	-1.39466125184662	0.196629929745794	Proteoglycans in cancer: FAS
hsa04370__28	0.163507722566454	DOWN	-1.39380088093246	0.196816790968845	VEGF signaling pathway: SHC2
hsa05200__217	0.164028424114704	DOWN	-1.39208013910415	0.197317163195601	Pathways in cancer: E2F1*
hsa04115__40	0.16455037406533	UP	1.39035939727584	0.197818395949299	p53 signaling pathway: PIDD1
hsa05231__60	0.166914636444722	DOWN	-1.38261605904844	0.200532354142987	Choline metabolism in cancer: PRKCA
hsa05205__434	0.168239099774858	DOWN	-1.37831420447766	0.201994420752049	Proteoglycans in cancer: CASP3
hsa05161__100	0.169571437105188	UP	1.37401234990688	0.203464067893134	Hepatitis B: MMP9*
hsa04115__3	0.172801303978573	UP	1.36368789893701	0.207207179435698	p53 signaling pathway: GADD45G
hsa05166__99	0.17995679624718	DOWN	-1.34131825516896	0.215649757747736	HTLV-I infection: JUN
hsa05150__66	0.182766764326482	UP	1.3327145460274	0.218877469833945	Staphylococcus aureus infection: IL10
hsa04210__106	0.183616064333105	UP	1.33013343328493	0.219614630733229	Apoptosis: TUBA1B
hsa04921__41	0.183616064333105	UP	1.33013343328493	0.219614630733229	Oxytocin signaling pathway: PTGS2
hsa05030__78	0.184753007160724	DOWN	-1.32669194962831	0.220833906141858	Cocaine addiction: GRIA2
hsa05200__193	0.185038055157255	UP	1.32583157871415	0.221034015028914	Pathways in cancer: NOS2
hsa05132__68	0.185323428389892	UP	1.3249712078	0.221234257906357	Salmonella infection: NOS2
hsa04115__9	0.187618141840263	DOWN	-1.31808824048675	0.223831421281177	p53 signaling pathway: RPRM
hsa05169__64	0.19109943620394	UP	1.30776378951688	0.227840000397972	Epstein-Barr virus infection: NFKB2
hsa05152__23	0.193741437709395	UP	1.30002045128948	0.230843475875683	Tuberculosis: PPP3CA
hsa05166__65	0.195814795945414	DOWN	-1.29399785489039	0.233166033955281	HTLV-I infection: PTTG2
hsa04742__46	0.196409951592379	DOWN	-1.29227711306207	0.233578918372835	Taste transduction: P2RY1
hsa05161__31	0.196410160207068	UP	1.29227711306207	0.233578918372835	Hepatitis B: ELK1
hsa04660__43	0.200614873606528	DOWN	-1.28023192026389	0.238428429795488	T cell receptor signaling pathway: RHOA
hsa04020__22	0.201828146033732	UP	1.27679043660727	0.239718765105804	Calcium signaling pathway: C00575
hsa04024__60	0.206116966868414	UP	1.26474524380909	0.244658105335281	cAMP signaling pathway: PDE3A
hsa04024__24	0.207044537780601	UP	1.26216413106662	0.245603968743528	cAMP signaling pathway: PLN
hsa05120__50	0.211413267481032	UP	1.25011893826844	0.250628094382877	Epithelial cell signaling in Helicobacter pylori infection: EGFR
hsa04710__11	0.21267363015768	DOWN	-1.24667745461182	0.251963273055663	Circadian rhythm: CRY1
hsa04915__66	0.218734471175536	DOWN	-1.23033040724285	0.2589805112406	Estrogen signaling pathway: AKT3*
hsa05223__23	0.220673953111067	DOWN	-1.22516818175792	0.261112316055224	Non-small cell lung cancer: CASP9*
hsa04071__68	0.225247292283209	UP	1.21312298895974	0.266355986280774	Sphingolipid signaling pathway: NFKB1
hsa05145__9	0.226896919634059	UP	1.20882113438896	0.26813793207069	Toxoplasmosis: MAPK1
hsa04550__62 63	0.230891130056176	UP	1.19849668341909	0.27268663317131	Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4
hsa04670__39	0.232233571527934	UP	1.19505519976246	0.274099799560922	Leukocyte transendothelial migration: MAPK14
hsa04911__4	0.234935052759678	DOWN	-1.18817223244922	0.277114227329212	Insulin secretion: CACNA1C
hsa04912__26	0.235953822530375	UP	1.18559111970675	0.278141300209896	GnRH signaling pathway: PLD1
hsa04151__4	0.240404593830787	DOWN	-1.17440629782272	0.283210176682162	PI3K-Akt signaling pathway: RPS6
hsa05212__29	0.241785887054622	UP	1.1709648141661	0.284658948480974	Pancreatic cancer: VEGFA
hsa04912__15	0.242478624132677	UP	1.16924407233779	0.285295763772887	GnRH signaling pathway: CAMK2A
hsa04919__91	0.243172755863878	UP	1.16752333050948	0.285933421945073	Thyroid hormone signaling pathway: PFKP
hsa05161__195	0.244216570070514	UP	1.16494221776701	0.286981197725138	Hepatitis B: IL6
hsa04620__40	0.246664360272392	DOWN	-1.15891962136792	0.289676458094891	Toll-like receptor signaling pathway: CCL5
hsa04612__18	0.247366875400472	DOWN	-1.15719887953961	0.290320024283252	Antigen processing and presentation: KIR2DS2
hsa04390__12	0.251967373569816	DOWN	-1.14601405765558	0.295534765878705	Hippo signaling pathway: CTGF
hsa04962__22	0.252323713011921	UP	1.14515368674143	0.295768095289706	Vasopressin-regulated water reabsorption: ARHGDIA
hsa04540__22	0.254827646278395	DOWN	-1.13913109034233	0.298516924786225	Gap junction: C00547
hsa05110__17	0.266495596766736	UP	1.11159922108935	0.311990795217879	Vibrio cholerae infection: C00698*
hsa05152__6	0.273594631354474	UP	1.09525217372039	0.320102311528678	Tuberculosis: IL10
hsa04931__144	0.274349348799247	DOWN	-1.09353143189208	0.32078557958543	Insulin resistance: C00533*
hsa04668__38	0.27472724033855	UP	1.09267106097792	0.321027664549835	TNF signaling pathway: CEBPB
hsa04010__13	0.280438276724269	UP	1.07976549726558	0.327497527635116	MAPK signaling pathway: STMN1
hsa04010__62	0.282359749373976	DOWN	-1.0754636426948	0.329536626753852	MAPK signaling pathway: MEF2C
hsa04920__37	0.28661834829453	DOWN	-1.06599956263909	0.334299116353458	Adipocytokine signaling pathway: IRS1
hsa04932__95	0.28700763320548	DOWN	-1.06513919172493	0.334545498010606	Non-alcoholic fatty liver disease (NAFLD): IL1A
hsa04340__26	0.288568340886767	DOWN	-1.06169770806831	0.336156176395682	Hedgehog signaling pathway: PTCH1**
hsa05010__61	0.291706890455435	DOWN	-1.05481474075506	0.339601764043223	Alzheimer's disease: GAPDH
hsa04010__65	0.294075803707452	DOWN	-1.04965251527013	0.341935912850435	MAPK signaling pathway: ELK4
hsa05321__74	0.294075803707452	UP	1.04965251527013	0.341935912850435	Inflammatory bowel disease (IBD): IL5
hsa05321__81	0.294471873231334	UP	1.04879214435597	0.342184693754902	Inflammatory bowel disease (IBD): IL13
hsa04064__142	0.296059725692244	DOWN	-1.04535066069935	0.343817196894763	NF-kappa B signaling pathway: NFKB2*
hsa05142__29	0.301662267381597	UP	1.03330546790117	0.350107103403348	Chagas disease (American trypanosomiasis): NOS2
hsa04910__20	0.302468354673239	UP	1.03158472607285	0.350825949648775	Insulin signaling pathway: PKLR
hsa04015__11	0.30570702077825	UP	1.02470175875961	0.354363659495578	Rap1 signaling pathway: RAC1
hsa05200__218	0.307334945850856	DOWN	-1.02126027510298	0.356031050094796	Pathways in cancer: CSF3R*
hsa04976__16	0.308559649419382	DOWN	-1.01867916236052	0.357229563314244	Bile secretion: CFTR
hsa05145__23	0.312665273482004	DOWN	-1.01007545321896	0.361759882310767	Toxoplasmosis: CIITA
hsa04270__46	0.314317552245918	UP	1.00663396956234	0.36344780348928	Vascular smooth muscle contraction: ITPR1*
hsa05140__62	0.316806716975465	UP	1.0014717440774	0.366100751043604	Leishmaniasis: C00584
hsa04152__52	0.31805613544095	UP	0.998890631334933	0.367318671477287	AMPK signaling pathway: PCK1
hsa05205__270	0.318890872239911	UP	0.997169889506621	0.368056479692134	Proteoglycans in cancer: MAPK1****
hsa04915__21	0.322664919745996	DOWN	-0.989426551279218	0.372183784040962	Estrogen signaling pathway: CREB3
hsa04151__102	0.329445970298356	DOWN	-0.975660616652725	0.379772379258044	PI3K-Akt signaling pathway: C8orf44-SGK3
hsa05120__53	0.330300046916262	DOWN	-0.973939874824413	0.380523475264045	Epithelial cell signaling in Helicobacter pylori infection: GIT1
hsa04152__103	0.331583846636973	DOWN	-0.971358762081946	0.381768411661074	AMPK signaling pathway: ULK1
hsa04610__44	0.334591905831326	UP	0.965336165682855	0.384995830408488	Complement and coagulation cascades: C3
hsa04668__40	0.33545457170057	UP	0.963615423854543	0.385752227800105	TNF signaling pathway: JUN
hsa05150__48	0.33631866853145	UP	0.961894682026231	0.386509344446847	Staphylococcus aureus infection: C3AR1
hsa04919__89	0.338919542858354	UP	0.956732456541296	0.389260281803696	Thyroid hormone signaling pathway: CASP9
hsa04650__25	0.341970163722275	DOWN	-0.950709860142205	0.392524091407547	Natural killer cell mediated cytotoxicity: SH2D1B
hsa04210__72	0.342844986127552	DOWN	-0.948989118313894	0.393287990801997	Apoptosis: BCL2A1
hsa05205__113	0.346358563787579	DOWN	-0.942106151000647	0.397076108210409	Proteoglycans in cancer: TP53
hsa04310__34	0.347240528824014	DOWN	-0.940385409172335	0.397844483939221	Wnt signaling pathway: FOSL1
hsa05169__29	0.348123921522478	DOWN	-0.938664667344024	0.398613557916354	Epstein-Barr virus infection: FCER2
hsa05133__73	0.367461507572676	DOWN	-0.901668718035322	0.420499496180912	Pertussis: FOS
hsa04666__51	0.367919038459314	DOWN	-0.900808347121167	0.420766812699362	Fc gamma R-mediated phagocytosis: NCF1
hsa05134__70	0.375751258067517	DOWN	-0.886182041580517	0.429462660528506	Legionellosis: IL6
hsa04360__108	0.377144026289124	DOWN	-0.88360092883805	0.430792477445145	Axon guidance: CFL1
hsa04623__8	0.378074304409586	UP	0.881880187009738	0.431592720525888	Cytosolic DNA-sensing pathway: TBK1
hsa04660__56	0.380406176148927	DOWN	-0.877578332438959	0.433991016990791	T cell receptor signaling pathway: CD3E
hsa04921__57	0.386038616606034	DOWN	-0.867253881469089	0.440149612016224	Oxytocin signaling pathway: FOS
hsa04912__20	0.388873833746531	DOWN	-0.862091655984154	0.443113361800929	GnRH signaling pathway: PLA2G4B
hsa05150__13	0.396017130118307	UP	0.849186092271816	0.45097950757109	Staphylococcus aureus infection: C5AR1
hsa05212__8	0.397935310265402	DOWN	-0.845744608615193	0.452889429429854	Pancreatic cancer: NFKB1
hsa05152__90	0.400340868915998	UP	0.841442754044414	0.45535138782879	Tuberculosis: CR1
hsa04668__128	0.403239100833714	DOWN	-0.836280528559479	0.458370399556291	TNF signaling pathway: CHUK*
hsa05164__65 66	0.403723354469306	UP	0.835420157645323	0.458643399666159	Influenza A: DNAJC3 HSPA1A
hsa04550__34	0.406636180730911	UP	0.830257932160388	0.461673343560956	Signaling pathways regulating pluripotency of stem cells: MAPK1*
hsa04270__17	0.409561511571551	DOWN	-0.825095706675453	0.464713816571827	Vascular smooth muscle contraction: ITPR1
hsa05145__35	0.410050280718025	DOWN	-0.824235335761297	0.464987614646451	Toxoplasmosis: CASP3
hsa04064__96	0.413972899877349	DOWN	-0.81735236844805	0.46915264105521	NF-kappa B signaling pathway: BCL2A1
hsa04668__20	0.415449587786544	DOWN	-0.814771255705582	0.470258900874046	TNF signaling pathway: IKBKG
hsa05133__96	0.415449587786544	UP	0.814771255705582	0.470258900874046	Pertussis: IL1B
hsa05166__32	0.421387376984711	UP	0.804446804735712	0.476692884620272	HTLV-I infection: STAT5A
hsa04022__63	0.424873958701225	DOWN	-0.798424208336621	0.480059030907758	cGMP-PKG signaling pathway: C00575
hsa05166__74	0.424873958701225	UP	0.798424208336621	0.480059030907758	HTLV-I infection: NFKB1
hsa04110__46	0.428377337194794	DOWN	-0.792401611937531	0.483726572469362	Cell cycle: RB1
hsa04072__27	0.428879188293472	DOWN	-0.791541241023375	0.484002399281342	Phospholipase D signaling pathway: C01245
hsa05110__14	0.435434296017256	DOWN	-0.780356419139349	0.490516212359967	Vibrio cholerae infection: C00238*
hsa05110__15	0.435434296017256	DOWN	-0.780356419139349	0.490516212359967	Vibrio cholerae infection: C01330
hsa05110__16	0.435434296017256	DOWN	-0.780356419139349	0.490516212359967	Vibrio cholerae infection: C00698
hsa04620__18	0.438987778492716	UP	0.774333822740258	0.494222909399529	Toll-like receptor signaling pathway: CXCL11
hsa04151__97	0.444092966830099	DOWN	-0.765730113598699	0.49967106866692	PI3K-Akt signaling pathway: MCL1
hsa04350__12	0.445118056581526	UP	0.764009371770388	0.500225375787492	TGF-beta signaling pathway: ACVR2A
hsa04520__44 52 45	0.445118056581526	UP	0.764009371770388	0.500225375787492	Adherens junction: ACTB ACTN4 CTNNA1
hsa05200__209	0.446144494106499	DOWN	-0.762288629942076	0.501079201689247	Pathways in cancer: FIGF**
hsa05214__27	0.447686674685992	DOWN	-0.759707517199609	0.502210902528346	Glioma: MTOR
hsa05214__48	0.447686674685992	DOWN	-0.759707517199609	0.502210902528346	Glioma: MTOR*
hsa04916__9	0.449231880562564	UP	0.757126404457141	0.503643617886073	Melanogenesis: PRKACA
hsa05016__12	0.458566398371258	UP	0.741639728002336	0.513802183983061	Huntington's disease: REST
hsa04151__73	0.466954248828644	UP	0.727873793375842	0.522888577800371	PI3K-Akt signaling pathway: MAPK1
hsa04530__11 43	0.470121496866514	DOWN	-0.722711567890907	0.526121675171042	Tight junction: TJP1 ACTN4
hsa04668__102	0.474894539978771	UP	0.714968229663505	0.531146928940542	TNF signaling pathway: AKT3
hsa05168__123	0.475426515357174	DOWN	-0.714107858749349	0.531425593311201	Herpes simplex infection: CYCS
hsa04062__33	0.476491446163812	UP	0.712387116921037	0.532299302819146	Chemokine signaling pathway: WAS
hsa04914__23	0.477557682410027	UP	0.710666375092726	0.533173431520167	Progesterone-mediated oocyte maturation: PRKACA
hsa04722__46	0.48022897405808	UP	0.706364520521946	0.535837436018487	Neurotrophin signaling pathway: ATF4*
hsa04022__57	0.48559590603274	DOWN	-0.697760811380388	0.541504277409803	cGMP-PKG signaling pathway: C00144
hsa04972__18	0.487212292717375	DOWN	-0.69517969863792	0.542984518396173	Pancreatic secretion: PRKCA
hsa04015__82	0.492621169510748	UP	0.686575989496362	0.548687123598515	Rap1 signaling pathway: ITGA2B
hsa05200__96	0.493706794678862	DOWN	-0.68485524766805	0.549570537441695	Pathways in cancer: C00416
hsa05164__34	0.497516546090635	UP	0.678832651268959	0.553483475491002	Influenza A: IL1B
hsa05150__35	0.499153660840949	DOWN	-0.676251538526492	0.554976170840321	Staphylococcus aureus infection: FCAR
hsa04261__4	0.50903908184178	UP	0.660764862071687	0.565632427427975	Adrenergic signaling in cardiomyocytes: SLC8A1
hsa05160__85	0.511249595436461	UP	0.657323378415063	0.567752949069214	Hepatitis C: BAD
hsa04064__114	0.512356729264165	DOWN	-0.655602636586752	0.56864636402089	NF-kappa B signaling pathway: BCL2A1*
hsa04921__54	0.51568561643246	UP	0.650440411101817	0.572003112914163	Oxytocin signaling pathway: RCAN1
hsa04660__34	0.516797734429224	DOWN	-0.648719669273505	0.57289849144101	T cell receptor signaling pathway: FOS
hsa04360__40 139	0.517354259035584	UP	0.647859298359349	0.57317727165558	Axon guidance: UNC5D DCC
hsa05205__17	0.519025692416178	DOWN	-0.645278185616882	0.574630555439312	Proteoglycans in cancer: AKT3
hsa04064__94	0.519583455929426	UP	0.644417814702726	0.574630555439312	NF-kappa B signaling pathway: BCL2L1*
hsa04931__46	0.519583455929426	UP	0.644417814702726	0.574630555439312	Insulin resistance: PIK3R5*
hsa05014__32 34	0.526862423261056	UP	0.6332329928187	0.58233793723972	Amyotrophic lateral sclerosis (ALS): NEFM PRPH
hsa04725__43	0.530239417609529	DOWN	-0.628070767333765	0.585725964543389	Cholinergic synapse: CREB3
hsa04210__52	0.531932027925401	DOWN	-0.625489654591297	0.587250458561591	Apoptosis: PARP2
hsa05014__13	0.537593761606154	UP	0.616885945449739	0.593152482711663	Amyotrophic lateral sclerosis (ALS): CASP3
hsa04152__53	0.538161595233249	UP	0.616025574535583	0.593430538405678	AMPK signaling pathway: G6PC
hsa05223__9	0.544998988105358	UP	0.605701123565713	0.600617653167137	Non-small cell lung cancer: BAD
hsa04668__111	0.547860578373977	DOWN	-0.601399268994934	0.603417366216121	TNF signaling pathway: BAG4
hsa05034__99	0.551304261706751	DOWN	-0.596237043509999	0.606854544667244	Alcoholism: PDYN
hsa04015__63	0.55245451641093	DOWN	-0.594516301681687	0.60740903237925	Rap1 signaling pathway: GNAI1
hsa04530__5 11 31	0.55245451641093	DOWN	-0.594516301681687	0.60740903237925	Tight junction: IGSF5 TJP1 MLLT4
hsa04620__48	0.555335295393827	DOWN	-0.590214447110908	0.610219309967837	Toll-like receptor signaling pathway: CD80
hsa04064__133	0.558223392660202	DOWN	-0.585912592540129	0.613034339455593	NF-kappa B signaling pathway: CXCL2
hsa05223__22	0.560539116135536	UP	0.582471108883505	0.615217873375393	Non-small cell lung cancer: BAD*
hsa04723__73	0.565184474560372	UP	0.575588141570258	0.6192312697953	Retrograde endocannabinoid signaling: MAPK14*
hsa04723__68	0.565184474560372	UP	0.575588141570258	0.6192312697953	Retrograde endocannabinoid signaling: MAPK14
hsa05160__54	0.565184474560372	DOWN	-0.575588141570258	0.6192312697953	Hepatitis C: IRF1
hsa05321__123	0.566931242461108	DOWN	-0.573007028827791	0.620783102904675	Inflammatory bowel disease (IBD): IL5*
hsa04910__39	0.579819301502379	DOWN	-0.554078868716362	0.634525607177036	Insulin signaling pathway: BAD
hsa04933__61	0.58099772390369	UP	0.552358126888051	0.635445124106539	AGE-RAGE signaling pathway in diabetic complications: MMP2
hsa04668__138	0.58335792540179	DOWN	-0.548916643231427	0.637655347196023	TNF signaling pathway: NFKB1*
hsa04910__12	0.585722586236198	UP	0.545475159574804	0.639867871824312	Insulin signaling pathway: FASN
hsa04064__53	0.587498996495786	DOWN	-0.542894046832336	0.641435569096794	NF-kappa B signaling pathway: CXCL8
hsa05020__59	0.589277895755358	UP	0.540312934089869	0.64300416151238	Prion diseases: CCL5
hsa04350__11	0.592843127708084	UP	0.535150708604934	0.64651899997881	TGF-beta signaling pathway: SMAD4*
hsa05152__82	0.594033731684349	DOWN	-0.533429966776622	0.647441636795181	Tuberculosis: IL6
hsa04723__46	0.598807046942389	DOWN	-0.526546999463375	0.652265763017246	Retrograde endocannabinoid signaling: ADCY1
hsa04921__53	0.60179917299166	UP	0.522245144892596	0.655145217874466	Oxytocin signaling pathway: RGS2
hsa04066__43	0.60419771717659	DOWN	-0.518803661235973	0.657375512782173	HIF-1 signaling pathway: PFKL
hsa04750__40	0.618071813462572	DOWN	-0.499015130210388	0.672081561051026	Inflammatory mediator regulation of TRP channels: C00219
hsa05134__68	0.618678185144068	DOWN	-0.498154759296233	0.672351827579933	Legionellosis: TNF
hsa04062__25	0.619891707331366	DOWN	-0.496434017467921	0.673281224321177	Chemokine signaling pathway: ROCK1
hsa04917__44	0.631471461579627	DOWN	-0.48008697009896	0.685462089143916	Prolactin signaling pathway: PRLR**
hsa04622__21 22 23	0.634534012967468	DOWN	-0.475785115528181	0.688388805061127	RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG
hsa04662__16	0.636374555749634	DOWN	-0.473204002785713	0.689987184220174	B cell receptor signaling pathway: VAV3
hsa04664__30	0.639447116455249	DOWN	-0.468902148214934	0.69291876114153	Fc epsilon RI signaling pathway: PRKCA
hsa05215__35	0.640062373821771	UP	0.468041777300778	0.693185706288822	Prostate cancer: CASP9
hsa04114__56	0.641909629974718	DOWN	-0.465460664558311	0.69478582645305	Oocyte meiosis: REC8
hsa05205__158	0.647464671211887	UP	0.457717326330908	0.700395001270659	Proteoglycans in cancer: PDCD4
hsa05166__53 146	0.651798895441766	DOWN	-0.451694729931817	0.704677862218112	HTLV-I infection: CREB1 CRTC2
hsa04722__33	0.65303941722322	UP	0.449973988103505	0.705613033330897	Neurotrophin signaling pathway: BAD
hsa04610__23	0.656766730666972	UP	0.44481176261857	0.709232578691518	Complement and coagulation cascades: BDKRB1
hsa04062__40	0.657388783976243	UP	0.443951391704414	0.709496568116807	Chemokine signaling pathway: PRKACA
hsa04390__94	0.662373726278438	DOWN	-0.437068424391168	0.714466263878981	Hippo signaling pathway: GLI2
hsa04933__25	0.677417805863982	DOWN	-0.416419522451428	0.73027427264396	AGE-RAGE signaling pathway in diabetic complications: IL1A
hsa04064__97	0.679937913663057	UP	0.412978038794804	0.732570722346838	NF-kappa B signaling pathway: PLCG2
hsa04012__56	0.682461601990094	UP	0.409536555138181	0.734868395495351	ErbB signaling pathway: JUN
hsa05016__60	0.683724781092145	DOWN	-0.407815813309869	0.735385726200424	Huntington's disease: CASP3*
hsa05134__35	0.683724781092145	DOWN	-0.407815813309869	0.735385726200424	Legionellosis: CASP3
hsa05212__54	0.690053901091352	DOWN	-0.399212104168311	0.741768466905407	Pancreatic cancer: C00416
hsa04390__58	0.693226642941958	UP	0.394910249597532	0.744752922863316	Hippo signaling pathway: SMAD7
hsa04066__37	0.694497251296401	DOWN	-0.39318950776922	0.74569162010625	HIF-1 signaling pathway: PDHA1
hsa04064__25	0.70022557312721	UP	0.385446169541817	0.75141282233354	NF-kappa B signaling pathway: NFKB2
hsa04261__23	0.700863114449759	UP	0.384585798627661	0.751667689526882	Adrenergic signaling in cardiomyocytes: SLC9A1
hsa03320__29	0.701500866524932	UP	0.383725427713506	0.751922491842754	PPAR signaling pathway: OLR1
hsa04917__38	0.707889889884986	DOWN	-0.375121718571947	0.758338143155011	Prolactin signaling pathway: IRF1
hsa04742__55	0.709809030876575	UP	0.37254060582948	0.759960780066715	Taste transduction: P2RX3
hsa04621__4 7 8	0.712374505145291	UP	0.369099122172856	0.762273174924831	NOD-like receptor signaling pathway: IKBKG CHUK IKBKB
hsa04064__136	0.716226400474332	DOWN	-0.363936896687921	0.765522984352258	NF-kappa B signaling pathway: TNFSF13B*
hsa05222__36	0.716226400474332	UP	0.363936896687921	0.765522984352258	Small cell lung cancer: PTGS2
hsa05031__96	0.716869088827565	UP	0.363076525773765	0.765774313761794	Amphetamine addiction: PDYN
hsa05110__51	0.717511973068867	UP	0.36221615485961	0.7660255667025	Vibrio cholerae infection: PDIA4
hsa04961__26	0.718155066790679	UP	0.361355783945454	0.766276757807886	Endocrine and other factor-regulated calcium reabsorption: TRPV5*
hsa04710__5	0.720085530668794	DOWN	-0.358774671202986	0.76790051766553	Circadian rhythm: RORA
hsa05134__6	0.720729416151936	UP	0.35791430028883	0.768151204168739	Legionellosis: IL1B
hsa05212__19	0.722662259354682	DOWN	-0.355333187546363	0.76977459485683	Pancreatic cancer: MAPK8
hsa04750__44	0.725241668287621	DOWN	-0.351891703889739	0.771647278999116	Inflammatory mediator regulation of TRP channels: TRPA1
hsa04750__63	0.725241668287621	DOWN	-0.351891703889739	0.771647278999116	Inflammatory mediator regulation of TRP channels: TRPA1*
hsa04530__4 37 11	0.726533248625904	UP	0.350170962061428	0.772584026127942	Tight junction: OCLN TJP3 TJP1
hsa04520__43	0.727179077944161	UP	0.349310591147272	0.772833420507397	Adherens junction: ACTB
hsa04662__36	0.727825137335589	UP	0.348450220233116	0.773082777305581	B cell receptor signaling pathway: CD79A
hsa05211__31	0.731058237480162	UP	0.344148365662337	0.77607820803685	Renal cell carcinoma: SOS1
hsa04914__11	0.741436045708298	UP	0.330382431035843	0.7866506662258	Progesterone-mediated oocyte maturation: CDK1
hsa04922__37	0.742086245584587	DOWN	-0.329522060121687	0.786896193822483	Glucagon signaling pathway: PYGB
hsa04917__57	0.745339998236656	DOWN	-0.325220205550908	0.789455387083809	Prolactin signaling pathway: ESR1
hsa05200__52	0.745339998236656	UP	0.325220205550908	0.789455387083809	Pathways in cancer: CDKN1B
hsa05321__46	0.745991296409657	UP	0.324359834636752	0.789700082227462	Inflammatory bowel disease (IBD): IFNG*
hsa04910__57	0.747946278452288	UP	0.321778721894285	0.79132379347514	Insulin signaling pathway: GCK
hsa04066__58	0.749902882700738	UP	0.319197609151817	0.79294739256876	HIF-1 signaling pathway: EDN1
hsa04918__10	0.759054807084166	UP	0.307152416353636	0.802173218510207	Thyroid hormone synthesis: TG
hsa04370__25	0.760365018211593	DOWN	-0.305431674525324	0.802654982707631	VEGF signaling pathway: PXN
hsa04725__18	0.760365018211593	DOWN	-0.305431674525324	0.802654982707631	Cholinergic synapse: ITPR1
hsa05132__13	0.761675917155888	DOWN	-0.303710932697012	0.80358733763948	Salmonella infection: FOS
hsa04550__47	0.765612705635949	UP	0.298548707212077	0.807287471318713	Signaling pathways regulating pluripotency of stem cells: CTNNB1*
hsa04976__59	0.766926320564337	DOWN	-0.296827965383765	0.808219044498255	Bile secretion: ABCB4
hsa05205__369	0.774163086166186	DOWN	-0.287363885328051	0.815388138400372	Proteoglycans in cancer: HOXD10
hsa03460__27	0.778778584090148	DOWN	-0.28134128892896	0.81978989328033	Fanconi anemia pathway: BRCA1
hsa04666__41	0.779438582508149	DOWN	-0.280480918014805	0.820025250018372	Fc gamma R-mediated phagocytosis: MARCKS
hsa04961__17	0.784062999419553	DOWN	-0.274458321615714	0.824428861728786	Endocrine and other factor-regulated calcium reabsorption: CALB1
hsa04024__115	0.784724257558355	UP	0.273597950701558	0.824662684536996	cAMP signaling pathway: F2R
hsa03460__16 34	0.7906825207433	UP	0.265854612474155	0.829995785741151	Fanconi anemia pathway: FANCM STRA13
hsa04210__31 32 33	0.7906825207433	DOWN	-0.265854612474155	0.829995785741151	Apoptosis: TRAF2 RIPK1 TRADD
hsa04370__38	0.792671348980541	UP	0.263273499731688	0.831618908282768	VEGF signaling pathway: BAD
hsa04917__47	0.801970194015728	DOWN	-0.251228306933506	0.840905130890376	Prolactin signaling pathway: INS
hsa04620__77	0.807296532270779	UP	0.244345339620259	0.845546367969227	Toll-like receptor signaling pathway: CXCL9
hsa05152__76	0.807296532270779	DOWN	-0.244345339620259	0.845546367969227	Tuberculosis: TNF*
hsa05321__122	0.808629524498903	UP	0.242624597791947	0.846470683305537	Inflammatory bowel disease (IBD): IL4**
hsa04210__3	0.817975819595181	UP	0.230579404993766	0.855524396800781	Apoptosis: BCL2L1
hsa04152__49	0.818644420142525	DOWN	-0.22971903407961	0.855524396800781	AMPK signaling pathway: GYS1
hsa04660__44	0.818644420142525	UP	0.22971903407961	0.855524396800781	T cell receptor signaling pathway: PAK4
hsa05205__324	0.826007628890952	UP	0.220254954023896	0.862739485650972	Proteoglycans in cancer: KDR*
hsa04062__53	0.83271477840347	UP	0.211651244882337	0.869261704788956	Chemokine signaling pathway: NFKB1
hsa05231__59	0.849534984195791	DOWN	-0.190141972028441	0.886327726431922	Choline metabolism in cancer: PLA2G4B
hsa03320__55	0.850209272956256	DOWN	-0.189281601114285	0.886538969969371	PPAR signaling pathway: SCD
hsa04530__11 33	0.8529075188706	DOWN	-0.185840117457662	0.888859250115284	Tight junction: TJP1 CGN
hsa05321__92	0.857633574820229	DOWN	-0.179817521058571	0.893289072664751	Inflammatory bowel disease (IBD): IL17F
hsa04660__26	0.861012466510809	DOWN	-0.175515666487792	0.896311592561668	T cell receptor signaling pathway: GRB2
hsa05152__94	0.863717415830219	UP	0.172074182831168	0.898629581586369	Tuberculosis: CAMP
hsa05133__27	0.865747178412908	UP	0.169493070088701	0.900242915460904	Pertussis: IRF3
hsa05205__319	0.86777782013038	DOWN	-0.166911957346233	0.901356847305882	Proteoglycans in cancer: KDR
hsa04670__2	0.867777826916626	UP	0.166911957346233	0.901356847305882	Leukocyte transendothelial migration: MMP2
hsa05145__67	0.87048671362747	DOWN	-0.16347047368961	0.90367101376023	Toxoplasmosis: BAD
hsa04620__12	0.873197120720972	UP	0.160028990032987	0.905984202007016	Toll-like receptor signaling pathway: NFKB1
hsa04390__5	0.877943897483439	DOWN	-0.154006393633896	0.910406502964339	Hippo signaling pathway: SAV1
hsa04962__10	0.879300933547422	DOWN	-0.152285651805584	0.911310785513296	Vasopressin-regulated water reabsorption: AQP2
hsa05200__187	0.884053326820837	DOWN	-0.146263055406493	0.915731092114858	Pathways in cancer: WNT16*
hsa04973__5	0.887450459910902	UP	0.141961200835714	0.918743478882967	Carbohydrate digestion and absorption: SLC2A5
hsa04919__101	0.888130136775985	UP	0.141100829921558	0.918829695142939	Thyroid hormone signaling pathway: NOTCH1
hsa04915__12 14	0.888809895906605	DOWN	-0.140240459007402	0.918829695142939	Estrogen signaling pathway: ESR1 FOS
hsa04915__3 11	0.889489736809476	DOWN	-0.139380088093246	0.918829695142939	Estrogen signaling pathway: ESR1 C00951
hsa04915__12 13	0.889489736809476	DOWN	-0.139380088093246	0.918829695142939	Estrogen signaling pathway: ESR1 C00951*
hsa05133__46	0.890849654466272	DOWN	-0.137659346264935	0.919728846561608	Pertussis: CFL1
hsa04620__34	0.892890150629964	UP	0.135078233522467	0.921329265806536	Toll-like receptor signaling pathway: IL1B
hsa04910__32	0.893570471797278	DOWN	-0.134217862608311	0.921525201156468	Insulin signaling pathway: EIF4E
hsa04064__2	0.898334885052253	UP	0.12819526620922	0.925422833888806	NF-kappa B signaling pathway: BCL2L1
hsa04931__104	0.898334885052253	DOWN	-0.12819526620922	0.925422833888806	Insulin resistance: C00369*
hsa04919__45	0.901740292710697	DOWN	-0.123893411638441	0.928421923289534	Thyroid hormone signaling pathway: SLC9A1
hsa04066__52	0.902421593328256	DOWN	-0.123033040724285	0.928614553046984	HIF-1 signaling pathway: FLT1
hsa04668__36	0.903784409676683	UP	0.121312298895974	0.929507884938416	TNF signaling pathway: CREB3
hsa05211__43	0.906510888909499	UP	0.11787081523935	0.931801947626339	Renal cell carcinoma: RAP1A
hsa04919__25	0.907192682178111	DOWN	-0.117010444325195	0.93199291952579	Thyroid hormone signaling pathway: MTOR
hsa04066__49	0.915379393216468	DOWN	-0.106685993355324	0.939889551832647	HIF-1 signaling pathway: EPO
hsa05213__12	0.918110336414114	DOWN	-0.103244509698701	0.942178766860798	Endometrial cancer: BAD
hsa04014__100	0.922208553335339	UP	0.098082284213766	0.945867833906715	Ras signaling pathway: REL
hsa04921__65	0.925625317223828	UP	0.0937804296429868	0.948854321365833	Oxytocin signaling pathway: TRPM2
hsa04370__39	0.926992410555304	UP	0.0920596878146751	0.949737589658351	VEGF signaling pathway: RAC1
hsa04917__33	0.929043453486962	DOWN	-0.0894785750722076	0.950284512303757	Prolactin signaling pathway: CSN2
hsa05205__129	0.929043453486962	UP	0.0894785750722076	0.950284512303757	Proteoglycans in cancer: AKT3*
hsa05211__46	0.929043453486962	UP	0.0894785750722076	0.950284512303757	Renal cell carcinoma: AKT3
hsa05161__26	0.929727239905661	DOWN	-0.0886182041580517	0.950466530893763	Hepatitis B: MMP9
hsa04668__120	0.936567874787297	UP	0.0800144950164933	0.956939117305781	TNF signaling pathway: DNM1L
hsa04210__51	0.939989980755721	UP	0.0757126404457141	0.959913681434783	Apoptosis: LMNA
hsa04022__59	0.944782777180106	UP	0.0696900440466232	0.964283996915491	cGMP-PKG signaling pathway: NPPB
hsa05012__57	0.948207437536103	DOWN	-0.065388189475844	0.967253949582159	Parkinson's disease: CASP3
hsa04917__45	0.950947857976712	UP	0.0619467058192206	0.969523073867739	Prolactin signaling pathway: SLC2A2
hsa04010__87	0.95368885864737	UP	0.0585052221625973	0.971790328307162	MAPK signaling pathway: STK3
hsa04550__101	0.96740143262582	UP	0.0412978038794804	0.985228884500768	Signaling pathways regulating pluripotency of stem cells: ESRRB
hsa05164__99	0.968087348244532	DOWN	-0.0404374329653246	0.985393351761363	Influenza A: FDPS
hsa03320__42	0.970831241753052	UP	0.0369959493087012	0.987651274095281	PPAR signaling pathway: ACOX1
hsa05222__32	0.974947719335936	DOWN	-0.0318337238237662	0.991302361813974	Small cell lung cancer: BIRC8
hsa05160__58	0.979064864302448	DOWN	-0.0266714983388311	0.994950178487993	Hepatitis C: EIF3E
hsa04610__7	0.97975111231806	DOWN	-0.0258111274246753	0.99510937299764	Complement and coagulation cascades: C00290
hsa04015__92	0.981123640089623	DOWN	-0.0240903855963636	0.995965056579363	Rap1 signaling pathway: C00076*
hsa05222__40	0.983868897343095	DOWN	-0.0206489019397402	0.998212558373475	Small cell lung cancer: TRAF1
hsa04933__28	0.984555239596748	UP	0.0197885310255844	0.998369830114565	AGE-RAGE signaling pathway in diabetic complications: VCAM1
hsa05145__33	0.986614332914369	UP	0.0172074182831168	0.999379154472291	Toxoplasmosis: STAT3
hsa05169__125	0.986614332914369	UP	0.0172074182831168	0.999379154472291	Epstein-Barr virus infection: STAT3
hsa05160__37	0.987300680352211	DOWN	-0.016347047368961	0.999535548697093	Hepatitis C: STAT3
hsa04010__107	0.989359927007594	UP	0.0137659346264935	1	MAPK signaling pathway: MAP3K2
hsa05031__101	0.992792093017013	DOWN	-0.00946408005571426	1	Amphetamine addiction: FOS*
hsa04152__33	1	0	0	1	AMPK signaling pathway: CPT1C
hsa04152__41	1	0	0	1	AMPK signaling pathway: FBP1
hsa04211__2	1	0	0	1	Longevity regulating pathway - mammal: RPS6KB1
hsa04911__41	1	0	0	1	Insulin secretion: ABCC8
hsa04911__35	1	0	0	1	Insulin secretion: TRPM4
hsa04922__67	1	0	0	1	Glucagon signaling pathway: FBP1
hsa04922__60	1	0	0	1	Glucagon signaling pathway: CPT1C*
hsa04924__34	1	0	0	1	Renin secretion: REN
hsa04924__47	1	0	0	1	Renin secretion: KCNMA1
hsa04931__151	1	0	0	1	Insulin resistance: CPT1A
hsa04931__29	1	0	0	1	Insulin resistance: CPT1B
hsa04960__15	1	0	0	1	Aldosterone-regulated sodium reabsorption: C00762
hsa05030__13	1	0	0	1	Cocaine addiction: SLC6A3
hsa05031__15	1	0	0	1	Amphetamine addiction: MAOA
hsa05031__77	1	0	0	1	Amphetamine addiction: MAOA*
hsa05034__7	1	0	0	1	Alcoholism: GRIN3A
hsa05034__75	1	0	0	1	Alcoholism: SLC29A1
hsa05140__37	1	0	0	1	Leishmaniasis: ELK1
hsa05140__55	1	0	0	1	Leishmaniasis: JUN
hsa05140__41 57	1	0	0	1	Leishmaniasis: NOS2 CYBA
hsa05211__12	1	0	0	1	Renal cell carcinoma: EGLN2