p.value UP.DOWN statistic FDRp.value path.name hsa04530__11 24 23 1.13354067632027e-28 DOWN -11.1098411972706 1.10241772212037e-25 Tight junction: TJP1 YBX3 CDK4 hsa04750__8 1.17340896447086e-28 DOWN -11.1066921493122 1.10241772212037e-25 Inflammatory mediator regulation of TRP channels: ASIC2 hsa05120__20 1.88817466207452e-28 UP 11.0641800018737 1.18262673001267e-25 Epithelial cell signaling in Helicobacter pylori infection: CXCL8 hsa04211__43 59 60 61 3.8013342790921e-28 UP 11.0011990427055 1.78567677760351e-25 Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101 hsa04010__13 8.61920136132812e-28 UP 10.9271964156828 3.23909587158711e-25 MAPK signaling pathway: STMN1 hsa05200__189 1.63478944986381e-27 UP 10.8689390284522 5.11961562715682e-25 Pathways in cancer: BIRC5 hsa05210__21 3.48455313748874e-27 UP 10.7996599733672 9.35353620763049e-25 Colorectal cancer: BIRC5 hsa04115__31 4.74256569852782e-27 DOWN -10.7713185417415 1.11391011844172e-24 p53 signaling pathway: ADGRB1 hsa04340__15 9.22295407191565e-27 DOWN -10.7099121065525 1.92554785568106e-24 Hedgehog signaling pathway: HHIP hsa04114__80 1.31745435524259e-26 UP 10.6768471029892 2.47549673350082e-24 Oocyte meiosis: CDC25C* hsa04914__30 1.75691437628491e-26 UP 10.6500801953428 3.00112919367213e-24 Progesterone-mediated oocyte maturation: CDK1* hsa04810__82 83 1.94450900140615e-26 UP 10.6406330514675 3.04477701136847e-24 Regulation of actin cytoskeleton: ACTB ARPC5 hsa04390__13 3.44914517413852e-26 UP 10.5870992361746 4.98534137092791e-24 Hippo signaling pathway: BIRC5 hsa04152__78 4.08021397053134e-26 UP 10.5713539963825 5.47623003616314e-24 AMPK signaling pathway: CCNA2 hsa04115__43 57 5.16016568502654e-26 UP 10.5493106606736 6.46396754810991e-24 p53 signaling pathway: CDK1 CCNB3 hsa05200__168 6.97387672076391e-26 UP 10.5209692290479 8.18994647394711e-24 Pathways in cancer: E2F1 hsa04919__28 7.70905155131257e-26 DOWN -10.5115220851727 8.46065832039696e-24 Thyroid hormone signaling pathway: RCAN1 hsa04110__59 15 16 17 18 19 20 8.10494144582998e-26 UP 10.5067985132351 8.46065832039696e-24 Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 hsa05166__64 9.41757390680896e-26 UP 10.4926277974223 9.19002028700858e-24 HTLV-I infection: CCNB2 hsa04151__34 1.00666331664197e-25 DOWN -10.4863297015054 9.19002028700858e-24 PI3K-Akt signaling pathway: GYS1 hsa04010__12 1.05823455809882e-25 UP 10.4816061295678 9.19002028700858e-24 MAPK signaling pathway: PLA2G4B hsa03460__7 1.07600024648318e-25 UP 10.4800316055886 9.19002028700858e-24 Fanconi anemia pathway: FANCI hsa04931__104 1.18897450358928e-25 DOWN -10.4705844617134 9.71340474888805e-24 Insulin resistance: C00369* hsa04115__11 12 1.47566494917166e-25 UP 10.4501156499837 1.15532268312231e-23 p53 signaling pathway: CDK2 CCNE1 hsa05166__65 6.29943781729545e-25 UP 10.3115575398137 4.7041861677945e-23 HTLV-I infection: PTTG2 hsa04910__46 6.50925174894395e-25 DOWN -10.3084084918553 4.7041861677945e-23 Insulin signaling pathway: FBP1 hsa04010__14 8.18495854322633e-25 UP 10.2863651561464 5.6961248528601e-23 MAPK signaling pathway: MAPT hsa04914__11 1.23069047737537e-24 UP 10.2470020566663 8.25881216781543e-23 Progesterone-mediated oocyte maturation: CDK1 hsa04931__140 1.335043104882e-24 DOWN -10.2391294367702 8.65015860025266e-23 Insulin resistance: G00369 hsa04976__95 96 1.49601346886217e-24 UP 10.2281077689158 9.37003102664006e-23 Bile secretion: SLC51A SLC51B hsa04961__13 2.39443101643807e-24 DOWN -10.1824465735189 1.4513341548023e-22 Endocrine and other factor-regulated calcium reabsorption: ATP2B1 hsa04110__10 11 12 13 14 9 15 16 17 18 19 20 2.6384715202853e-24 UP 10.1729994296436 1.52681539600986e-22 Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 hsa04024__25 2.68147461779272e-24 DOWN -10.1714249056644 1.52681539600986e-22 cAMP signaling pathway: CFTR hsa05214__35 3.15157619923056e-24 UP 10.1556796658724 1.741709317163e-22 Glioma: E2F1 hsa04960__3 3.58570288068509e-24 DOWN -10.1430834740387 1.92501020365923e-22 Aldosterone-regulated sodium reabsorption: SCNN1A hsa04115__38 4.35026807732788e-24 UP 10.1241891862883 2.2705982548053e-22 p53 signaling pathway: GTSE1 hsa04922__36 4.63940683584794e-24 DOWN -10.1178910903715 2.3560663363671e-22 Glucagon signaling pathway: GYS1 hsa05212__34 5.27599203100677e-24 UP 10.1052948985378 2.60883921743729e-22 Pancreatic cancer: E2F1 hsa05140__62 7.87715428901514e-24 DOWN -10.0659317990577 3.79517254078448e-22 Leishmaniasis: C00584 hsa05130__9 9.54290378793406e-24 DOWN -10.0470375113072 4.48277905438203e-22 Pathogenic Escherichia coli infection: TLR4 hsa05200__192 1.69319075863991e-23 DOWN -9.99035464805585 7.75976935483996e-22 Pathways in cancer: PTGS2 hsa04725__61 1.9844190042063e-23 DOWN -9.9746094082638 8.87791264024674e-22 Cholinergic synapse: FOS hsa04961__12 2.55679281933402e-23 DOWN -9.94941702459652 1.11725900175084e-21 Endocrine and other factor-regulated calcium reabsorption: SLC8A1 hsa04024__114 3.91567279863961e-23 DOWN -9.90690487715798 1.67217027014633e-21 cAMP signaling pathway: HHIP hsa03460__25 40 5.03657028647473e-23 UP 9.8817124934907 2.10304790406356e-21 Fanconi anemia pathway: MLH1 PMS2 hsa05030__73 5.98604399635086e-23 DOWN -9.86439272971945 2.4451688411181e-21 Cocaine addiction: NFKB1 hsa04152__94 8.0610224507662e-23 DOWN -9.83447677411455 3.15555441353952e-21 AMPK signaling pathway: MLYCD hsa04910__42 8.0610224507662e-23 DOWN -9.83447677411455 3.15555441353952e-21 Insulin signaling pathway: PCK1 hsa04722__50 8.99314533914026e-23 UP 9.82345510626012 3.44859593719276e-21 Neurotrophin signaling pathway: RHOA hsa04390__90 9.42457921292058e-23 UP 9.8187315343225 3.54175686821555e-21 Hippo signaling pathway: BBC3 hsa04152__49 1.01896181089672e-22 DOWN -9.81085891442648 3.75417498563713e-21 AMPK signaling pathway: GYS1 hsa04014__69 1.19088500214982e-22 UP 9.79511367463443 4.30321715199908e-21 Ras signaling pathway: PLCE1* hsa05134__73 1.32802036774112e-22 DOWN -9.78409200677999 4.70820805846333e-21 Legionellosis: CXCL1 hsa03460__48 1.39147412437935e-22 UP 9.77936843484238 4.84181459205332e-21 Fanconi anemia pathway: RAD51 hsa05134__69 1.84033143821439e-22 DOWN -9.75102700321669 6.28724140437242e-21 Legionellosis: IL1B* hsa05132__20 2.54751791662973e-22 UP 9.71796199965338 8.49822251957484e-21 Salmonella infection: ACTB hsa05020__52 2.62749784416231e-22 DOWN -9.71481295169497 8.49822251957484e-21 Prion diseases: FYN hsa04114__59 2.66841473472547e-22 UP 9.71323842771577 8.49822251957484e-21 Oocyte meiosis: REC8* hsa05217__19 2.66841473472547e-22 DOWN -9.71323842771577 8.49822251957484e-21 Basal cell carcinoma: HHIP hsa05231__17 3.31203466806327e-22 DOWN -9.69119509200689 1.03603501718786e-20 Choline metabolism in cancer: SLC44A3 hsa04924__31 3.36339201960934e-22 DOWN -9.68962056802769 1.03603501718786e-20 Renin secretion: C02135 hsa05014__5 3.63286053179895e-22 UP 9.68174794813167 1.10099111923391e-20 Amyotrophic lateral sclerosis (ALS): TOMM40 hsa04722__53 4.10891829670858e-22 DOWN -9.66915175629803 1.22550118722467e-20 Neurotrophin signaling pathway: JUN hsa04622__45 4.30293179273061e-22 UP 9.66442818436041 1.263313881022e-20 RIG-I-like receptor signaling pathway: MAPK14 hsa05031__98 5.6726339855779e-22 DOWN -9.63608675273472 1.63982757829244e-20 Amphetamine addiction: FOS hsa04722__84 6.31489405240247e-22 DOWN -9.62506508488029 1.7978312006764e-20 Neurotrophin signaling pathway: NFKB1* hsa04110__60 10 11 12 13 14 9 6.51126575826683e-22 DOWN -9.62191603692187 1.82606990444528e-20 Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 hsa05133__46 1.14534032811642e-21 UP 9.56365864969129 3.16484481842757e-20 Pertussis: CFL1 hsa05210__53 1.27400963425419e-21 DOWN -9.55263698183685 3.46936826487482e-20 Colorectal cancer: CCND1* hsa04010__134 1.37457360892557e-21 UP 9.54476436194083 3.68974830167306e-20 MAPK signaling pathway: ATF4* hsa03460__16 49 1.3956093249031e-21 UP 9.54318983796162 3.69345059365199e-20 Fanconi anemia pathway: FANCM C19orf40 hsa03460__16 34 1.69985975735114e-21 UP 9.52272102623196 4.43616178342053e-20 Fanconi anemia pathway: FANCM STRA13 hsa05031__101 1.72581419216693e-21 DOWN -9.52114650225275 4.44219844805708e-20 Amphetamine addiction: FOS* hsa04931__87 1.9480640264133e-21 DOWN -9.50855031041911 4.94650311571702e-20 Insulin resistance: C00031* hsa04921__41 2.30053857975156e-21 DOWN -9.49123054664786 5.68777893599104e-20 Oxytocin signaling pathway: PTGS2 hsa05222__40 2.30053857975156e-21 UP 9.49123054664786 5.68777893599104e-20 Small cell lung cancer: TRAF1 hsa04931__124 2.40716148701696e-21 DOWN -9.48650697471024 5.87409926507125e-20 Insulin resistance: FOXO1* hsa04919__39 2.67533342819357e-21 DOWN -9.47548530685581 6.44480963022527e-20 Thyroid hormone signaling pathway: ESR1 hsa04064__129 3.50829856905376e-21 DOWN -9.44714387523012 8.3444215332304e-20 NF-kappa B signaling pathway: PTGS2 hsa04068__60 3.89747012164521e-21 DOWN -9.43612220737568 9.15418294821418e-20 FoxO signaling pathway: RAG1 hsa05034__84 3.95644506633728e-21 DOWN -9.43454768339648 9.1779756538861e-20 Alcoholism: FOSB hsa04024__110 4.52854107479107e-21 DOWN -9.42037696758363 1.03769861945517e-19 cAMP signaling pathway: FOS hsa05131__38 5.10530889098729e-21 UP 9.40778077574999 1.15576812122471e-19 Shigellosis: CXCL8 hsa05020__48 6.48552175999481e-21 DOWN -9.38258839208271 1.45074945083693e-19 Prion diseases: SOD1 hsa05010__37 6.58310902289117e-21 UP 9.38101386810351 1.45525433576618e-19 Alzheimer's disease: MAPT hsa04261__4 9.00313273680088e-21 DOWN -9.3479488645402 1.96707981540103e-19 Adrenergic signaling in cardiomyocytes: SLC8A1 hsa05152__6 9.41409415081417e-21 DOWN -9.34322529260259 2.03322792061837e-19 Tuberculosis: IL10 hsa04213__60 1.04465444185362e-20 DOWN -9.33220362474815 2.23057465482154e-19 Longevity regulating pathway - multiple species: CAT hsa04722__37 1.0761570979721e-20 UP 9.32905457678974 2.27202155852762e-19 Neurotrophin signaling pathway: NFKB1 hsa05020__49 1.36441492061443e-20 UP 9.30386219312246 2.84859515092725e-19 Prion diseases: BAX hsa04730__7 1.58207565474798e-20 DOWN -9.28811695333041 3.26672544535326e-19 Long-term depression: GNA13 hsa04068__45 2.35642394072367e-20 DOWN -9.24560480589188 4.81273976589106e-19 FoxO signaling pathway: RBL2 hsa04919__88 2.46280845808278e-20 DOWN -9.24088123395426 4.97593235778231e-19 Thyroid hormone signaling pathway: FOXO1 hsa04910__43 2.6900249313238e-20 DOWN -9.23143409007903 5.37718813399726e-19 Insulin signaling pathway: G6PC hsa04015__96 3.71497410057137e-20 UP 9.19679456253652 7.34782772102485e-19 Rap1 signaling pathway: PLCE1 hsa05200__185 4.1764727073798e-20 DOWN -9.18419837070288 8.17457522621526e-19 Pathways in cancer: HHIP hsa04068__52 4.36377425765862e-20 DOWN -9.17947479876526 8.45312559808303e-19 FoxO signaling pathway: CAT hsa04115__2 4.49323056628933e-20 DOWN -9.17632575080686 8.6150818714874e-19 p53 signaling pathway: IGFBP3 hsa04922__50 4.83371614921009e-20 DOWN -9.16845313091083 9.17429560036945e-19 Glucagon signaling pathway: PCK1 hsa04261__66 5.51206662976557e-20 DOWN -9.15428241509798 1.03571731973295e-18 Adrenergic signaling in cardiomyocytes: C01245 hsa05222__35 6.01573585866528e-20 UP 9.14483527122275 1.11916511667644e-18 Small cell lung cancer: NOS2 hsa04610__45 9.57571212960273e-20 DOWN -9.09445050388819 1.76399638152192e-18 Complement and coagulation cascades: C4A hsa04213__61 9.85717647912428e-20 DOWN -9.09130145592978 1.79821695187131e-18 Longevity regulating pathway - multiple species: ATG5 hsa04010__88 92 1.04448608615134e-19 DOWN -9.08500336001296 1.88710514988304e-18 MAPK signaling pathway: ECSIT TRAF6 hsa05162__62 1.09082247413135e-19 UP 9.08027978807535 1.95205278942172e-18 Measles: IL12A hsa04211__56 1.15577793366232e-19 DOWN -9.07398169215853 2.04877994089765e-18 Longevity regulating pathway - mammal: CAT hsa04210__84 1.18967455399904e-19 DOWN -9.07083264420012 2.08915746445251e-18 Apoptosis: FAS** hsa05131__12 1.27877453590559e-19 UP 9.06296002430409 2.22483088237649e-18 Shigellosis: ARPC5 hsa04611__92 1.29737028834053e-19 UP 9.06138550032489 2.23647593742373e-18 Platelet activation: RHOA* hsa04024__9 95 1.33536715699606e-19 DOWN -9.05823645236648 2.28104989817781e-18 cAMP signaling pathway: ATP1B4 FXYD1 hsa05020__59 1.61059275169705e-19 DOWN -9.03776764063681 2.72639980219707e-18 Prion diseases: CCL5 hsa05164__36 1.807088575435e-19 DOWN -9.02517144880317 3.03171377968068e-18 Influenza A: IL33 hsa04360__3 1.9140388390106e-19 DOWN -9.01887335288635 3.15480612149203e-18 Axon guidance: GNAI1 hsa04921__57 1.9140388390106e-19 DOWN -9.01887335288635 3.15480612149203e-18 Oxytocin signaling pathway: FOS hsa04666__38 1.96983574086268e-19 UP 9.01572430492794 3.21854031050519e-18 Fc gamma R-mediated phagocytosis: CFL1 hsa04390__88 2.08629527899124e-19 DOWN -9.00942620901112 3.37943864588322e-18 Hippo signaling pathway: ID1 hsa04068__47 2.24147568193039e-19 DOWN -9.0015535891151 3.56926509012475e-18 FoxO signaling pathway: GADD45G hsa04068__54 2.24147568193039e-19 DOWN -9.0015535891151 3.56926509012475e-18 FoxO signaling pathway: GADD45G* hsa04913__19 2.30669345858379e-19 DOWN -8.99840454115669 3.64224958712517e-18 Ovarian steroidogenesis: STAR hsa04020__22 2.40791796947446e-19 UP 8.99368096921907 3.77039822053542e-18 Calcium signaling pathway: C00575 hsa04921__55 3.02766741210029e-19 DOWN -8.96848858555179 4.70164220441028e-18 Oxytocin signaling pathway: PTGS2* hsa04068__13 3.25183178986358e-19 DOWN -8.96061596565577 5.00835404356858e-18 FoxO signaling pathway: PCK1 hsa04360__117 3.49237904888963e-19 UP 8.95274334575974 5.33510588037693e-18 Axon guidance: CFL1* hsa05164__20 3.85893357114091e-19 DOWN -8.94172167790531 5.84752917755949e-18 Influenza A: ATF2 hsa04360__125 3.91431093918941e-19 UP 8.9401471539261 5.88399220378953e-18 Axon guidance: ENAH* hsa04933__52 4.26344916510604e-19 DOWN -8.93070001005087 6.35795315970972e-18 AGE-RAGE signaling pathway in diabetic complications: FOXO1 hsa04622__21 22 23 4.32455733464297e-19 UP 8.92912548607167 6.39830175731822e-18 RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG hsa05200__217 4.91494778276976e-19 UP 8.91495477025882 7.2149897529878e-18 Pathways in cancer: E2F1* hsa04931__149 4.98527175934519e-19 DOWN -8.91338024627962 7.26149274093768e-18 Insulin resistance: ACACB* hsa05205__158 5.05658955537457e-19 DOWN -8.91180572230041 7.30871674965294e-18 Proteoglycans in cancer: PDCD4 hsa04913__35 5.42857785059905e-19 DOWN -8.90393310240439 7.78648685593559e-18 Ovarian steroidogenesis: HSD17B2 hsa04066__56 5.58483014331864e-19 DOWN -8.90078405444598 7.94992109037555e-18 HIF-1 signaling pathway: TEK hsa05166__99 5.82757453633495e-19 DOWN -8.89606048250836 8.23309214569426e-18 HTLV-I infection: JUN hsa03460__27 6.90722415259422e-19 UP 8.8771661947579 9.6855777483019e-18 Fanconi anemia pathway: BRCA1 hsa04115__22 7.20665180059899e-19 DOWN -8.87244262282029 1.00305916543152e-17 p53 signaling pathway: STEAP3 hsa04931__35 7.30928238862916e-19 DOWN -8.87086809884108 1.00986335354663e-17 Insulin resistance: C00369 hsa04360__111 8.30037437251868e-19 UP 8.85669738302824 1.13842360919435e-17 Axon guidance: RHOA*** hsa04024__77 9.03368824274058e-19 UP 8.84725023915301 1.23002175421084e-17 cAMP signaling pathway: RHOA* hsa04960__13 9.83092125421453e-19 DOWN -8.83780309527778 1.32894252062368e-17 Aldosterone-regulated sodium reabsorption: FXYD4 hsa05132__54 1.06975675549626e-18 DOWN -8.82835595140254 1.43576638826963e-17 Salmonella infection: IL1B hsa03460__28 1.69980854424898e-18 UP 8.77639666008878 2.26520585435733e-17 Fanconi anemia pathway: RAD51C hsa04650__25 1.74804079510238e-18 DOWN -8.77324761213037 2.29690115664151e-17 Natural killer cell mediated cytotoxicity: SH2D1B hsa04910__48 1.74804079510238e-18 DOWN -8.77324761213037 2.29690115664151e-17 Insulin signaling pathway: PPARGC1A hsa05166__120 1.84859558559445e-18 UP 8.76694951621355 2.41216048981388e-17 HTLV-I infection: E2F1 hsa04022__65 2.18580213506994e-18 DOWN -8.74805522846309 2.83249807710097e-17 cGMP-PKG signaling pathway: PDE2A hsa04213__52 2.34361372011552e-18 DOWN -8.74018260856706 3.01619875349114e-17 Longevity regulating pathway - multiple species: SOD2 hsa04022__60 2.51266522042912e-18 UP 8.73230998867104 3.21176731237165e-17 cGMP-PKG signaling pathway: TRPC6* hsa04115__40 2.92811378456037e-18 DOWN -8.71499022489978 3.71751743323577e-17 p53 signaling pathway: PIDD1 hsa04370__14 3.05273599978614e-18 DOWN -8.71026665296217 3.84972546550212e-17 VEGF signaling pathway: PTGS2 hsa04066__61 3.18259206660374e-18 DOWN -8.70554308102455 3.98672699543229e-17 HIF-1 signaling pathway: HMOX1 hsa03320__30 3.22707771876181e-18 UP 8.70396855704535 4.01568147917446e-17 PPAR signaling pathway: LPL hsa04920__10 3.27217716999164e-18 DOWN -8.70239403306614 4.04501375158835e-17 Adipocytokine signaling pathway: PCK1 hsa04211__57 3.7588255890437e-18 DOWN -8.68664879327409 4.61623090314583e-17 Longevity regulating pathway - mammal: ATG5 hsa04610__46 3.86431514765575e-18 DOWN -8.68349974531568 4.7149663392501e-17 Complement and coagulation cascades: C2 hsa04922__17 4.37689623185687e-18 DOWN -8.66932902950284 5.30592775461875e-17 Glucagon signaling pathway: PKM hsa04068__50 4.56220746539876e-18 DOWN -8.66460545756522 5.49512040223351e-17 FoxO signaling pathway: TNFSF10 hsa04621__33 35 5.23763440982456e-18 DOWN -8.64886021777317 6.26848092742697e-17 NOD-like receptor signaling pathway: NLRC4 PYCARD hsa04010__79 5.45886672425175e-18 UP 8.64413664583556 6.4919054271323e-17 MAPK signaling pathway: HSPB1 hsa04933__30 6.01158510589841e-18 UP 8.63311497798112 7.10425686414032e-17 AGE-RAGE signaling pathway in diabetic complications: CXCL8 hsa04064__116 6.09492735398843e-18 DOWN -8.63154045400192 7.15773031134016e-17 NF-kappa B signaling pathway: GADD45B hsa05205__129 6.43985421853912e-18 DOWN -8.6252423580851 7.51582986126398e-17 Proteoglycans in cancer: AKT3* hsa05161__227 6.71112764295749e-18 DOWN -8.62051878614748 7.73632444240315e-17 Hepatitis B: MYD88* hsa05211__46 6.71112764295749e-18 DOWN -8.62051878614748 7.73632444240315e-17 Renal cell carcinoma: AKT3 hsa04921__54 6.89821127148437e-18 DOWN -8.61736973818907 7.90349937751166e-17 Oxytocin signaling pathway: RCAN1 hsa04152__89 7.38873968269322e-18 DOWN -8.60949711829305 8.41420719017004e-17 AMPK signaling pathway: CFTR hsa04020__64 9.71941372958768e-18 DOWN -8.57800663870895 1.09357954478415e-16 Calcium signaling pathway: C01330* hsa04020__12 9.71941372958768e-18 DOWN -8.57800663870895 1.09357954478415e-16 Calcium signaling pathway: C01330 hsa04921__34 35 1.06958178833228e-17 UP 8.56698497085451 1.19627629778354e-16 Oxytocin signaling pathway: MYL9 ACTB hsa04151__36 1.14519059249512e-17 DOWN -8.55911235095849 1.27326220313511e-16 PI3K-Akt signaling pathway: PCK1 hsa04062__60 1.1768899091379e-17 UP 8.55596330300008 1.30080949368831e-16 Chemokine signaling pathway: GSK3A hsa04064__133 1.20945483322983e-17 DOWN -8.55281425504167 1.32401376206167e-16 NF-kappa B signaling pathway: CXCL2 hsa04360__4 1.22606915699165e-17 DOWN -8.55123973106246 1.32401376206167e-16 Axon guidance: GNAI1* hsa05110__12 1.22606915699165e-17 UP 8.55123973106246 1.32401376206167e-16 Vibrio cholerae infection: C00080 hsa05120__35 1.22606915699165e-17 UP 8.55123973106246 1.32401376206167e-16 Epithelial cell signaling in Helicobacter pylori infection: C00080 hsa05150__14 1.27725407615322e-17 DOWN -8.54651615912485 1.37140594805251e-16 Staphylococcus aureus infection: FPR1 hsa04010__78 1.31257941015397e-17 DOWN -8.54336711116644 1.39341057157024e-16 MAPK signaling pathway: MAP3K4 hsa04068__14 1.31257941015397e-17 DOWN -8.54336711116644 1.39341057157024e-16 FoxO signaling pathway: G6PC hsa05222__39 1.36734845174338e-17 UP 8.53864353922882 1.44339760720551e-16 Small cell lung cancer: BCL2L1 hsa04350__44 45 1.42437142368436e-17 UP 8.53391996729121 1.49519212575582e-16 TGF-beta signaling pathway: TGFBR2 TGFBR1 hsa04115__3 1.46368392472175e-17 DOWN -8.5307709193328 1.52792338586232e-16 p53 signaling pathway: GADD45G hsa05142__21 1.50406672127043e-17 DOWN -8.52762187137439 1.56140407141831e-16 Chagas disease (American trypanosomiasis): TICAM1 hsa05166__62 63 1.54554854111431e-17 UP 8.52447282341598 1.59565148832626e-16 HTLV-I infection: ANAPC10 CDC20 hsa04750__59 1.86927170432114e-17 DOWN -8.50242948770711 1.90889213718447e-16 Inflammatory mediator regulation of TRP channels: TRPV2 hsa05110__17 1.86927170432114e-17 DOWN -8.50242948770711 1.90889213718447e-16 Vibrio cholerae infection: C00698* hsa05161__213 2.14061018118355e-17 UP 8.48668424791506 2.17416569213183e-16 Hepatitis B: E2F1 hsa05218__21 2.51788260844076e-17 UP 8.46778996016459 2.51654330918095e-16 Melanoma: RB1 hsa05220__40 2.51788260844076e-17 UP 8.46778996016459 2.51654330918095e-16 Chronic myeloid leukemia: RB1 hsa05222__32 2.51788260844076e-17 UP 8.46778996016459 2.51654330918095e-16 Small cell lung cancer: BIRC8 hsa05223__28 2.96060405053605e-17 UP 8.44889567241414 2.9433730216705e-16 Non-small cell lung cancer: RB1 hsa04620__34 3.00078922747237e-17 DOWN -8.44732114843493 2.95208531854481e-16 Toll-like receptor signaling pathway: IL1B hsa04913__40 3.00078922747237e-17 DOWN -8.44732114843493 2.95208531854481e-16 Ovarian steroidogenesis: HSD17B1 hsa04115__17 3.77233864428733e-17 UP 8.42055424078844 3.69178349615411e-16 p53 signaling pathway: TP73 hsa04210__83 4.03441175731367e-17 DOWN -8.41268162089242 3.90755654226412e-16 Apoptosis: TP53* hsa04932__28 4.03441175731367e-17 UP 8.41268162089242 3.90755654226412e-16 Non-alcoholic fatty liver disease (NAFLD): GSK3A hsa04660__44 4.31442778046385e-17 DOWN -8.40480900099639 4.15733835871362e-16 T cell receptor signaling pathway: PAK4 hsa04068__59 4.67584081799686e-17 DOWN -8.39536185712116 4.48260453929393e-16 FoxO signaling pathway: S1PR1 hsa04014__26 5.49057705551482e-17 UP 8.37646756937071 5.23695141487936e-16 Ras signaling pathway: PRKCA hsa04922__51 5.56447600410359e-17 DOWN -8.3748930453915 5.28063152106598e-16 Glucagon signaling pathway: G6PC hsa04014__30 6.19207615492703e-17 UP 8.36229685355786 5.84668899251652e-16 Ras signaling pathway: C01245 hsa04340__33 7.87072452421948e-17 DOWN -8.33395542193217 7.3945456905042e-16 Hedgehog signaling pathway: HHIP* hsa05200__227 8.08293050508346e-17 DOWN -8.33080637397376 7.55613254679195e-16 Pathways in cancer: FOXO1 hsa03320__21 9.23157424826413e-17 DOWN -8.31506113418171 8.58719208539025e-16 PPAR signaling pathway: ACAA1 hsa04068__55 9.73483939728533e-17 DOWN -8.30876303826489 9.01072080172371e-16 FoxO signaling pathway: ATM hsa05205__337 9.86482513553072e-17 UP 8.30718851428568 9.08627766159913e-16 Proteoglycans in cancer: CTNNB1** hsa05164__53 1.09682149240261e-16 DOWN -8.29459232245204 1.00533052889e-15 Influenza A: MAPK14 hsa05152__90 1.12620851329194e-16 DOWN -8.29144327449363 1.02725524100755e-15 Tuberculosis: CR1 hsa05211__43 1.15646831472053e-16 DOWN -8.28829422653522 1.04976036877289e-15 Renal cell carcinoma: RAP1A hsa04115__29 1.41001610693919e-16 DOWN -8.26467636684715 1.27375974275901e-15 p53 signaling pathway: IGF1 hsa04152__30 1.4477205139152e-16 UP 8.26152731888874 1.30156308404146e-15 AMPK signaling pathway: ACACA hsa05134__59 1.56689971310189e-16 UP 8.25208017501351 1.40200217186593e-15 Legionellosis: HSPA1A hsa04066__46 1.58768215115625e-16 DOWN -8.2505056510343 1.41386481612445e-15 HIF-1 signaling pathway: ENO1 hsa04064__128 1.76402289955273e-16 DOWN -8.23790945920066 1.56349010766961e-15 NF-kappa B signaling pathway: IL1B* hsa03320__26 1.81104299996994e-16 DOWN -8.23476041124225 1.59762901264954e-15 PPAR signaling pathway: CPT2 hsa04530__20 22 1.90882056036753e-16 UP 8.22846231532543 1.67601580978065e-15 Tight junction: ACTB MYL12B hsa05205__103 1.95964274140981e-16 DOWN -8.22531326736702 1.71263660981815e-15 Proteoglycans in cancer: CCND1 hsa04923__16 2.01179838006599e-16 DOWN -8.22216421940861 1.75007831302963e-15 Regulation of lipolysis in adipocytes: PLIN1 hsa05133__73 2.06532193244063e-16 DOWN -8.2190151714502 1.78835940601656e-15 Pertussis: FOS hsa04211__50 2.12024873085154e-16 DOWN -8.21586612349179 1.82749879140827e-15 Longevity regulating pathway - mammal: PPARGC1A* hsa04380__51 2.64915441063288e-16 DOWN -8.18909921584531 2.27295029113204e-15 Osteoclast differentiation: FOS* hsa05211__31 2.82810846454192e-16 DOWN -8.18122659594928 2.4154617294883e-15 Renal cell carcinoma: SOS1 hsa04068__57 3.18074596259247e-16 DOWN -8.16705588013644 2.70435369398699e-15 FoxO signaling pathway: IL7R hsa04068__58 3.39502865715792e-16 DOWN -8.15918326024041 2.87354002108096e-15 FoxO signaling pathway: KLF2 hsa04914__42 3.53036313004975e-16 DOWN -8.1544596883028 2.96140728632298e-15 Progesterone-mediated oocyte maturation: ARAF hsa04933__12 3.53036313004975e-16 DOWN -8.1544596883028 2.96140728632298e-15 AGE-RAGE signaling pathway in diabetic complications: EGR1 hsa04213__71 3.96907994425432e-16 DOWN -8.14028897248995 3.31462276233505e-15 Longevity regulating pathway - multiple species: SIRT1** hsa05133__24 4.07364064914515e-16 DOWN -8.13713992453154 3.38688972555032e-15 Pertussis: NFKB1 hsa05150__35 4.18062035917342e-16 DOWN -8.13399087657313 3.41562577387165e-15 Staphylococcus aureus infection: FCAR hsa04015__92 4.18089395106086e-16 UP 8.13399087657313 3.41562577387165e-15 Rap1 signaling pathway: C00076* hsa04390__89 4.18091499728835e-16 DOWN -8.13399087657313 3.41562577387165e-15 Hippo signaling pathway: ID2 hsa04922__78 4.18091499728835e-16 DOWN -8.13399087657313 3.41562577387165e-15 Glucagon signaling pathway: ACACA hsa04068__40 5.41906040544731e-16 DOWN -8.10250039698903 4.38897176803254e-15 FoxO signaling pathway: CCND1 hsa05200__214 5.41906040544731e-16 DOWN -8.10250039698903 4.38897176803254e-15 Pathways in cancer: CSF3R hsa05164__34 5.93269603261755e-16 DOWN -8.0914787291346 4.78435014819243e-15 Influenza A: IL1B hsa04350__32 6.1672432190483e-16 UP 8.08675515719698 4.95224359341528e-15 TGF-beta signaling pathway: RPS6KB1 hsa04919__104 6.32865985254796e-16 DOWN -8.08360610923857 5.0602348352926e-15 Thyroid hormone signaling pathway: MYC hsa04660__35 6.49423778439858e-16 DOWN -8.08045706128016 5.14880708729322e-15 T cell receptor signaling pathway: NFATC1 hsa05132__13 6.49423778439858e-16 DOWN -8.08045706128016 5.14880708729322e-15 Salmonella infection: FOS hsa04211__23 7.5811940135776e-16 DOWN -8.0615627735297 5.98532081996315e-15 Longevity regulating pathway - mammal: SOD2 hsa04660__43 7.77900984460872e-16 DOWN -8.05841372557129 6.11579895314635e-15 T cell receptor signaling pathway: RHOA hsa05010__59 8.0852654243677e-16 UP 8.05369015363368 6.33008905516121e-15 Alzheimer's disease: LRP1 hsa04913__12 8.2960721631582e-16 DOWN -8.05054110567526 6.46818240438766e-15 Ovarian steroidogenesis: HSD3B1 hsa04915__3 11 8.51225001911015e-16 DOWN -8.04739205771686 6.55513024012622e-15 Estrogen signaling pathway: ESR1 C00951 hsa04915__12 14 8.51225001911015e-16 DOWN -8.04739205771686 6.55513024012622e-15 Estrogen signaling pathway: ESR1 FOS hsa04915__12 13 8.51225001911015e-16 DOWN -8.04739205771686 6.55513024012622e-15 Estrogen signaling pathway: ESR1 C00951* hsa04210__85 8.62241067594636e-16 DOWN -8.04581753373765 6.61286108575641e-15 Apoptosis: FASLG* hsa05133__96 9.0772735100725e-16 DOWN -8.03951943782083 6.93341338431961e-15 Pertussis: IL1B hsa04066__54 1.00590718553598e-15 DOWN -8.02692324598719 7.65222510778178e-15 HIF-1 signaling pathway: SERPINE1 hsa04012__8 1.10034625047321e-15 DOWN -8.01590157813276 8.30341608288822e-15 ErbB signaling pathway: STAT5A hsa04390__5 1.10034625047321e-15 DOWN -8.01590157813276 8.30341608288822e-15 Hippo signaling pathway: SAV1 hsa05200__212 1.11453182400001e-15 DOWN -8.01432705415355 8.37682118918404e-15 Pathways in cancer: CCND1*** hsa04722__85 1.1434455836575e-15 DOWN -8.01117800619514 8.55989741710139e-15 Neurotrophin signaling pathway: BAX hsa04668__40 1.18820693671731e-15 DOWN -8.00645443425752 8.85968584957075e-15 TNF signaling pathway: JUN hsa04211__42 1.59378072756231e-15 DOWN -7.97024038273581 1.17902125475967e-14 Longevity regulating pathway - mammal: PPARGC1A hsa04211__38 1.59378072756231e-15 UP 7.97024038273581 1.17902125475967e-14 Longevity regulating pathway - mammal: BAX hsa04728__36 1.95340094091732e-15 DOWN -7.94504799906853 1.43385535009463e-14 Dopaminergic synapse: TH hsa04022__19 1.95352298895277e-15 DOWN -7.94504799906853 1.43385535009463e-14 cGMP-PKG signaling pathway: CNGB1 hsa04152__64 2.21780986425116e-15 DOWN -7.92930275927648 1.6215037879097e-14 AMPK signaling pathway: ACACB hsa04970__12 2.24558395667541e-15 UP 7.92772823529727 1.6354466103074e-14 Salivary secretion: BEST2 hsa05166__39 2.27474508632488e-15 UP 7.92615371131807 1.65028803753068e-14 HTLV-I infection: RRAS2 hsa04068__67 2.51723635914712e-15 DOWN -7.91355751948443 1.81918735339902e-14 FoxO signaling pathway: GABARAP hsa04152__15 2.61458769679663e-15 DOWN -7.90883394754681 1.88230279014592e-14 AMPK signaling pathway: FOXO1 hsa04925__3 2.7156442841019e-15 DOWN -7.9041103756092 1.94759374420896e-14 Aldosterone synthesis and secretion: ITPR1 hsa04064__55 2.75017702680713e-15 DOWN -7.90253585162999 1.95741766415553e-14 NF-kappa B signaling pathway: CXCL12 hsa04068__88 2.75017702680713e-15 DOWN -7.90253585162999 1.95741766415553e-14 FoxO signaling pathway: FBXO32 hsa04068__44 2.78514209207939e-15 DOWN -7.90096132765079 1.97482339283667e-14 FoxO signaling pathway: CDKN1B hsa05231__59 4.06401477330236e-15 UP 7.85372560827464 2.87078336805832e-14 Choline metabolism in cancer: PLA2G4B hsa04151__26 4.32726788459769e-15 DOWN -7.84585298837861 3.04529451504085e-14 PI3K-Akt signaling pathway: RBL2 hsa04152__61 4.66540105555334e-15 UP 7.83640584450338 3.2710032027555e-14 AMPK signaling pathway: RPS6KB1 hsa05150__13 5.3541970460113e-15 DOWN -7.81908608073213 3.73997630091273e-14 Staphylococcus aureus infection: C5AR1 hsa04540__14 31 5.4215671105524e-15 DOWN -7.81751155675292 3.77300911138073e-14 Gap junction: GJA1 TJP1 hsa04068__53 5.48977146358572e-15 DOWN -7.81593703277372 3.8063765978146e-14 FoxO signaling pathway: SOD2 hsa04213__62 5.62872379819552e-15 DOWN -7.81278798481531 3.88837206500345e-14 Longevity regulating pathway - multiple species: CAT* hsa05030__37 5.91709521221735e-15 DOWN -7.80648988889849 4.07260875595473e-14 Cocaine addiction: PRKACA hsa04915__58 6.37712119253186e-15 DOWN -7.79704274502326 4.37321559152094e-14 Estrogen signaling pathway: CREB3*** hsa05169__45 6.62015884600685e-15 DOWN -7.79231917308564 4.52337398968977e-14 Epstein-Barr virus infection: RB1 hsa05215__46 7.31372098888117e-15 DOWN -7.779722981252 4.97916005003903e-14 Prostate cancer: MTOR hsa05162__25 70 7.78301129187036e-15 DOWN -7.77185036135598 5.27952282217488e-14 Measles: IFNAR1 GNB2L1 hsa05161__195 7.97891698407063e-15 DOWN -7.76870131339757 5.39294424930529e-14 Hepatitis B: IL6 hsa04066__49 8.49016449569166e-15 DOWN -7.76082869350154 5.71792798831707e-14 HIF-1 signaling pathway: EPO hsa04350__21 8.59621670522312e-15 UP 7.75925416952234 5.76867542468366e-14 TGF-beta signaling pathway: CDKN2B hsa04068__43 8.81224727769798e-15 DOWN -7.75610512156393 5.89260236113683e-14 FoxO signaling pathway: CDKN1A hsa04540__14 16 1.02252404204392e-14 DOWN -7.73721083381347 6.78912606007251e-14 Gap junction: GJA1 GJA1 hsa04540__14 15 1.02252404204392e-14 DOWN -7.73721083381347 6.78912606007251e-14 Gap junction: GJA1 GJA1* hsa04750__51 1.10129526137504e-14 DOWN -7.72776368993824 7.26082033727616e-14 Inflammatory mediator regulation of TRP channels: TRPV4 hsa04750__61 1.10129526137504e-14 DOWN -7.72776368993824 7.26082033727616e-14 Inflammatory mediator regulation of TRP channels: TRPV4* hsa05160__22 23 1.12887695596001e-14 DOWN -7.72461464197983 7.41664265821278e-14 Hepatitis C: STAT1 IRF9 hsa05031__11 1.15712233191809e-14 UP 7.72146559402142 7.54941965859058e-14 Amphetamine addiction: GRIN3A hsa05031__54 1.15712233191809e-14 UP 7.72146559402142 7.54941965859058e-14 Amphetamine addiction: GRIN3A* hsa04724__5 71 1.17150465554484e-14 UP 7.71989107004221 7.59054223368538e-14 Glutamatergic synapse: GRIN3A DLG4 hsa04810__21 82 1.17150465554484e-14 UP 7.71989107004221 7.59054223368538e-14 Regulation of actin cytoskeleton: CFL1 ACTB hsa05162__23 1.23081389573342e-14 UP 7.71359297412539 7.94742030956391e-14 Measles: IRF3 hsa04068__46 1.29307525174037e-14 DOWN -7.70729487820857 8.32085067815119e-14 FoxO signaling pathway: PLK4 hsa05020__24 1.32533983115566e-14 DOWN -7.70414583025016 8.41322142818068e-14 Prion diseases: PRNP* hsa05020__26 1.32533983115566e-14 DOWN -7.70414583025016 8.41322142818068e-14 Prion diseases: PRNP** hsa05020__25 8 1.32533983115566e-14 DOWN -7.70414583025016 8.41322142818068e-14 Prion diseases: PRNP PRNP* hsa05020__10 34 1.32533983115566e-14 DOWN -7.70414583025016 8.41322142818068e-14 Prion diseases: PRNP PRNP*** hsa03320__64 1.37527392121298e-14 DOWN -7.69942225831255 8.70080706383563e-14 PPAR signaling pathway: APOA5 hsa04932__95 1.51760494958413e-14 DOWN -7.68682606647891 9.56905939687442e-14 Non-alcoholic fatty liver disease (NAFLD): IL1A hsa03320__22 1.53638534075015e-14 DOWN -7.6852515424997 9.65507710792486e-14 PPAR signaling pathway: ACADM hsa04068__66 1.57463469169341e-14 DOWN -7.68210249454129 9.86246195230639e-14 FoxO signaling pathway: BNIP3 hsa04970__18 1.82460447871303e-14 DOWN -7.66320820679083 1.13524232301384e-13 Salivary secretion: VAMP2 hsa05205__140 1.82460447871303e-14 DOWN -7.66320820679083 1.13524232301384e-13 Proteoglycans in cancer: MAPK1*** hsa04510__19 26 1.96383934862526e-14 UP 7.6537610629156 1.21783964886695e-13 Focal adhesion: VCL ACTN4 hsa04068__48 2.38828050777661e-14 DOWN -7.62856867924832 1.47617732701061e-13 FoxO signaling pathway: FASLG hsa04750__62 2.76463611718879e-14 DOWN -7.60967439149786 1.70319713580254e-13 Inflammatory mediator regulation of TRP channels: TRPM8* hsa04921__80 2.90264144082841e-14 UP 7.60337629558104 1.78237361677013e-13 Oxytocin signaling pathway: KCNJ2 hsa04976__37 3.16058777445712e-14 DOWN -7.5923546277266 1.9344444391547e-13 Bile secretion: ABCB11 hsa05160__15 16 3.19923161886586e-14 DOWN -7.5907801037474 1.95173902982109e-13 Hepatitis C: TRAF6 RIPK1 hsa05205__415 3.23834005183272e-14 DOWN -7.58920557976819 1.96920419333129e-13 Proteoglycans in cancer: MAPK1****** hsa05134__6 3.2779185606685e-14 DOWN -7.58763105578899 1.98684160499875e-13 Legionellosis: IL1B hsa04022__23 3.35850807397157e-14 UP 7.58448200783058 2.02914362411337e-13 cGMP-PKG signaling pathway: CACNA1C hsa05200__146 147 3.48298250531157e-14 DOWN -7.57975843589296 2.08424335270078e-13 Pathways in cancer: RARB RXRA hsa05222__14 15 3.48298250531157e-14 DOWN -7.57975843589296 2.08424335270078e-13 Small cell lung cancer: RXRA RARB hsa05223__29 34 3.48298250531157e-14 DOWN -7.57975843589296 2.08424335270078e-13 Non-small cell lung cancer: RARB RXRA hsa05215__25 3.56860472330325e-14 DOWN -7.57660938793455 2.12870103971009e-13 Prostate cancer: FOXO1 hsa05205__431 3.65621602846791e-14 DOWN -7.57346033997614 2.1740601004719e-13 Proteoglycans in cancer: CDKN1A* hsa05205__188 3.93193766731457e-14 DOWN -7.56401319610091 2.33063434602021e-13 Proteoglycans in cancer: TNF hsa04713__61 4.2795258351364e-14 DOWN -7.55299152824648 2.52868837868594e-13 Circadian entrainment: FOS hsa04360__108 4.71386004653973e-14 UP 7.54039533641284 2.75929689328603e-13 Axon guidance: CFL1 hsa04550__36 4.71386004653973e-14 DOWN -7.54039533641284 2.75929689328603e-13 Signaling pathways regulating pluripotency of stem cells: AKT3* hsa04610__58 4.71386004653973e-14 UP 7.54039533641284 2.75929689328603e-13 Complement and coagulation cascades: F2RL2 hsa03320__58 5.12923487620771e-14 DOWN -7.5293736685584 2.97465246930953e-13 PPAR signaling pathway: CYP8B1 hsa03320__23 5.12925705192277e-14 DOWN -7.5293736685584 2.97465246930953e-13 PPAR signaling pathway: ACADL hsa04933__19 5.12925705192277e-14 DOWN -7.5293736685584 2.97465246930953e-13 AGE-RAGE signaling pathway in diabetic complications: TGFBR2 hsa05205__109 5.78577101285514e-14 UP 7.51362842876635 3.34506576404764e-13 Proteoglycans in cancer: SMAD2 hsa05150__66 5.85579807238516e-14 DOWN -7.51205390478715 3.37516704846985e-13 Staphylococcus aureus infection: IL10 hsa04024__76 6.07091691735467e-14 DOWN -7.50733033284953 3.48845654058392e-13 cAMP signaling pathway: C00416 hsa04210__86 6.68327817130241e-14 DOWN -7.49473414101589 3.82862185484062e-13 Apoptosis: BCL2L11 hsa04510__19 23 6.76397006446854e-14 UP 7.49315961703669 3.86306983317215e-13 Focal adhesion: VCL TLN1 hsa04540__1 7.01156590192183e-14 DOWN -7.48843604509907 3.99234313021549e-13 Gap junction: C00681 hsa05215__39 8.69785002889058e-14 UP 7.46009461347338 4.93754084721613e-13 Prostate cancer: RB1 hsa05220__50 9.34391861543621e-14 UP 7.45064746959815 5.28832020433875e-13 Chronic myeloid leukemia: MAPK1 hsa05140__21 9.45608851635809e-14 DOWN -7.44907294561895 5.33573282950055e-13 Leishmaniasis: NFKB1 hsa04151__37 9.80059899146027e-14 DOWN -7.44434937368133 5.51357051046523e-13 PI3K-Akt signaling pathway: G6PC hsa04115__30 1.02791983634922e-13 DOWN -7.43805127776451 5.76555633582143e-13 p53 signaling pathway: SERPINE1 hsa04914__34 1.04023929728321e-13 DOWN -7.43647675378531 5.78286875619868e-13 Progesterone-mediated oocyte maturation: MAPK14 hsa04931__61 1.04023929728321e-13 DOWN -7.43647675378531 5.78286875619868e-13 Insulin resistance: ACACB hsa05231__50 1.04023929728321e-13 UP 7.43647675378531 5.78286875619868e-13 Choline metabolism in cancer: WASF2 hsa04919__27 1.06531513577409e-13 DOWN -7.4333277058269 5.9047998233614e-13 Thyroid hormone signaling pathway: GATA4 hsa04915__40 1.11726211262601e-13 DOWN -7.42702960991008 6.17451620477725e-13 Estrogen signaling pathway: CREB3** hsa04610__52 1.19988262134569e-13 UP 7.41758246603485 6.61166992817755e-13 Complement and coagulation cascades: CPB2 hsa04622__9 35 1.30388179228409e-13 UP 7.40656079818041 7.16372481784152e-13 RIG-I-like receptor signaling pathway: IRF3 PIN1 hsa04370__16 1.45069317471976e-13 UP 7.39239008236757 7.92398975377452e-13 VEGF signaling pathway: HSPB1 hsa05134__68 1.45069317471976e-13 DOWN -7.39239008236757 7.92398975377452e-13 Legionellosis: TNF hsa04622__44 1.55746926071425e-13 UP 7.38294293849234 8.48256446632485e-13 RIG-I-like receptor signaling pathway: MAPK8 hsa05211__41 1.69182670934745e-13 UP 7.3719212706379 9.18769475972214e-13 Renal cell carcinoma: PDGFB* hsa04210__102 1.75283609107238e-13 DOWN -7.36719769870029 9.49158217615276e-13 Apoptosis: PIDD1 hsa04360__59 1.85935585263313e-13 UP 7.35932507880426 1.00394530089013e-12 Axon guidance: MAPK1* hsa04921__53 2.01923907301169e-13 DOWN -7.34830341094983 1.087149059653e-12 Oxytocin signaling pathway: RGS2 hsa05030__69 2.06734992345838e-13 DOWN -7.34515436299142 1.1098715731938e-12 Cocaine addiction: PRKACA** hsa05168__91 92 2.19260850088639e-13 DOWN -7.33728174309539 1.17376392397879e-12 Herpes simplex infection: STAT1 IRF9 hsa04921__33 2.32531466001707e-13 DOWN -7.32940912319937 1.24126881993525e-12 Oxytocin signaling pathway: C00942 hsa04010__58 2.38057886747722e-13 UP 7.32626007524096 1.2671693178441e-12 MAPK signaling pathway: CDC25B hsa04916__10 2.70839206560635e-13 DOWN -7.3089403114697 1.43759002578371e-12 Melanogenesis: CAMK2A hsa04810__8 79 2.74030386677141e-13 UP 7.3073657874905 1.44635701282682e-12 Regulation of actin cytoskeleton: ARPC5 ACTB hsa04810__8 82 2.74030386677141e-13 UP 7.3073657874905 1.44635701282682e-12 Regulation of actin cytoskeleton: ARPC5 ACTB* hsa04360__21 3.54363626897221e-13 UP 7.27272625994799 1.86512396341703e-12 Axon guidance: PAK4 hsa05134__70 3.58518842548867e-13 DOWN -7.27115173596878 1.88172319874112e-12 Legionellosis: IL6 hsa04622__5 33 3.75623533026643e-13 UP 7.26485364005196 1.96600729403081e-12 RIG-I-like receptor signaling pathway: MAVS TMEM173 hsa04668__111 3.88975535149051e-13 DOWN -7.26013006811435 2.03023619595852e-12 TNF signaling pathway: BAG4 hsa04550__66 3.93528933296789e-13 DOWN -7.25855554413514 2.04265432504051e-12 Signaling pathways regulating pluripotency of stem cells: MYC hsa04660__34 3.93528933296789e-13 DOWN -7.25855554413514 2.04265432504051e-12 T cell receptor signaling pathway: FOS hsa03320__7 4.42040722092317e-13 DOWN -7.24281030434309 2.28185306816336e-12 PPAR signaling pathway: AQP7 hsa05164__41 42 4.42040722092317e-13 DOWN -7.24281030434309 2.28185306816336e-12 Influenza A: STAT1 IRF9 hsa04925__33 4.8503667672078e-13 DOWN -7.23021411250945 2.49694223440643e-12 Aldosterone synthesis and secretion: CYP11B2 hsa04066__29 5.19953329312589e-13 DOWN -7.22076696863422 2.66937788464031e-12 HIF-1 signaling pathway: LDHA hsa04012__21 5.38325523182315e-13 UP 7.21604339669661 2.74867841864013e-12 ErbB signaling pathway: GSK3B hsa04210__114 5.38325523182315e-13 DOWN -7.21604339669661 2.74867841864013e-12 Apoptosis: HRK hsa04022__48 5.44590077641091e-13 DOWN -7.2144688727174 2.76563447537192e-12 cGMP-PKG signaling pathway: SLC8A2 hsa05221__21 5.44590077641091e-13 DOWN -7.2144688727174 2.76563447537192e-12 Acute myeloid leukemia: PIM1 hsa05134__71 5.57334665477987e-13 DOWN -7.21131982475899 2.8227273219222e-12 Legionellosis: CXCL8 hsa04213__13 5.77002399829771e-13 DOWN -7.20659625282137 2.91448255182833e-12 Longevity regulating pathway - multiple species: RPS6KB1* hsa04650__40 5.83708509198461e-13 DOWN -7.20502172884217 2.94045117636436e-12 Natural killer cell mediated cytotoxicity: TNFRSF10D hsa04922__59 6.18403842479267e-13 DOWN -7.19714910894615 3.10690058828488e-12 Glucagon signaling pathway: CPT1C hsa04014__104 6.40184532276207e-13 UP 7.19242553700853 3.20775129639198e-12 Ras signaling pathway: BRAP* hsa04068__49 6.62717826205993e-13 DOWN -7.18770196507091 3.31182658361984e-12 FoxO signaling pathway: BCL2L11 hsa04350__34 7.35092435153774e-13 UP 7.17353124925807 3.66376309192027e-12 TGF-beta signaling pathway: ROCK1 hsa04650__116 7.87595483306978e-13 DOWN -7.16408410538284 3.91505797125347e-12 Natural killer cell mediated cytotoxicity: FCGR3A hsa04024__111 7.96696773642584e-13 DOWN -7.16250958140363 3.93945588861688e-12 cAMP signaling pathway: JUN hsa04976__16 7.96696773642584e-13 DOWN -7.16250958140363 3.93945588861688e-12 Bile secretion: CFTR hsa04914__39 8.73320612094813e-13 DOWN -7.14991338956999 4.30700637828387e-12 Progesterone-mediated oocyte maturation: PIK3R5 hsa04066__50 8.93579703830176e-13 DOWN -7.14676434161158 4.3839066932034e-12 HIF-1 signaling pathway: TF hsa04961__26 8.93579703830176e-13 DOWN -7.14676434161158 4.3839066932034e-12 Endocrine and other factor-regulated calcium reabsorption: TRPV5* hsa04960__4 9.57164685841498e-13 DOWN -7.13731719773635 4.68362615806295e-12 Aldosterone-regulated sodium reabsorption: ATP1B4 hsa05166__60 1.0020000908009e-12 UP 7.13101910181953 4.89028096263609e-12 HTLV-I infection: POLD3 hsa04742__67 1.07314318555599e-12 UP 7.1215719579443 5.22392757942927e-12 Taste transduction: PRKACA hsa05200__215 1.0854728260272e-12 DOWN -7.1199974339651 5.27029312688657e-12 Pathways in cancer: CSF1R hsa04660__40 41 1.09794145144767e-12 DOWN -7.11842290998589 5.31709275069632e-12 T cell receptor signaling pathway: LAT GRAP2 hsa04620__76 1.12330181549102e-12 DOWN -7.11527386202748 5.41201054181444e-12 Toll-like receptor signaling pathway: CCL3L3 hsa04666__42 1.12330181549102e-12 DOWN -7.11527386202748 5.41201054181444e-12 Fc gamma R-mediated phagocytosis: MYO10 hsa04068__51 1.14923676148594e-12 DOWN -7.11212481406907 5.50871396640837e-12 FoxO signaling pathway: BCL6 hsa04068__56 1.14923676148594e-12 DOWN -7.11212481406907 5.50871396640837e-12 FoxO signaling pathway: BCL6* hsa04916__9 1.18924449905926e-12 DOWN -7.10740124213146 5.68598069651996e-12 Melanogenesis: PRKACA hsa05161__194 1.21667231128405e-12 DOWN -7.10425219417305 5.80235348452467e-12 Hepatitis B: TNF* hsa04972__42 1.24472057348816e-12 DOWN -7.10110314621464 5.92108850021329e-12 Pancreatic secretion: CFTR hsa04151__109 1.28798647194758e-12 UP 7.09637957427702 6.09603672742946e-12 PI3K-Akt signaling pathway: RXRA hsa04210__51 1.28798647194758e-12 UP 7.09637957427702 6.09603672742946e-12 Apoptosis: LMNA hsa04010__119 1.30273374960075e-12 DOWN -7.09480505029782 6.11959178874952e-12 MAPK signaling pathway: NFATC3 hsa04014__64 1.30273374960075e-12 UP 7.09480505029782 6.11959178874952e-12 Ras signaling pathway: PIK3R5* hsa05211__48 1.30273374960075e-12 DOWN -7.09480505029782 6.11959178874952e-12 Renal cell carcinoma: JUN hsa04010__61 1.34797677122055e-12 UP 7.0900814783602 6.31633005766436e-12 MAPK signaling pathway: ATF4 hsa04360__6 1.36339765099079e-12 UP 7.088506954381 6.37269698062613e-12 Axon guidance: MAPK1 hsa05219__19 1.5448780953067e-12 DOWN -7.07118719060974 7.20304203742257e-12 Bladder cancer: TP53 hsa03320__44 1.61657549613568e-12 DOWN -7.06488909469292 7.51867662682905e-12 PPAR signaling pathway: FABP1 hsa04068__96 1.87291027748304e-12 DOWN -7.04442028296326 8.66797638273552e-12 FoxO signaling pathway: CCNG2 hsa05164__78 1.87291027748304e-12 UP 7.04442028296326 8.66797638273552e-12 Influenza A: GSK3B hsa04728__44 1.95951463209038e-12 DOWN -7.03812218704644 9.0465061270217e-12 Dopaminergic synapse: FOS hsa05162__81 2.07330954179625e-12 DOWN -7.03024956715041 9.54840350253712e-12 Measles: TNFRSF10D hsa04152__24 2.48277053678024e-12 DOWN -7.00505718348313 1.14061756445234e-11 AMPK signaling pathway: SIRT1 hsa05205__434 2.53922748494657e-12 DOWN -7.00190813552472 1.16370937663771e-11 Proteoglycans in cancer: CASP3 hsa03320__47 2.65594441049618e-12 DOWN -6.9956100396079 1.20835824390371e-11 PPAR signaling pathway: PLTP hsa05150__69 2.65594441049618e-12 DOWN -6.9956100396079 1.20835824390371e-11 Staphylococcus aureus infection: FPR2 hsa05223__14 2.65594441049618e-12 DOWN -6.9956100396079 1.20835824390371e-11 Non-small cell lung cancer: CCND1 hsa05212__19 2.71625991300447e-12 DOWN -6.99246099164949 1.2328145837042e-11 Pancreatic cancer: MAPK8 hsa04010__54 2.74691936187008e-12 DOWN -6.99088646767029 1.2407359329216e-11 MAPK signaling pathway: NR4A1 hsa05164__99 2.74691936187008e-12 UP 6.99088646767029 1.2407359329216e-11 Influenza A: FDPS hsa04071__48 2.77781436023594e-12 DOWN -6.98931194369108 1.25168181843725e-11 Sphingolipid signaling pathway: SMPD1 hsa04612__17 28 2.90538030020595e-12 DOWN -6.98301384777426 1.30603100097775e-11 Antigen processing and presentation: CD4 HLA-DMA hsa04068__68 3.39830407303797e-12 DOWN -6.96097051206539 1.51672526205186e-11 FoxO signaling pathway: ATG12 hsa04261__73 3.39830407303797e-12 DOWN -6.96097051206539 1.51672526205186e-11 Adrenergic signaling in cardiomyocytes: KCNE1 hsa04910__9 3.39830407303797e-12 UP 6.96097051206539 1.51672526205186e-11 Insulin signaling pathway: ELK1 hsa04340__26 3.55360939684895e-12 UP 6.95467241614857 1.58228247788606e-11 Hedgehog signaling pathway: PTCH1** hsa05169__30 3.59351044113173e-12 DOWN -6.95309789216937 1.59626622195899e-11 Epstein-Barr virus infection: FGR hsa03320__42 4.64257954278105e-12 DOWN -6.91688384064765 2.05740730209566e-11 PPAR signaling pathway: ACOX1 hsa05034__62 4.90758798260926e-12 DOWN -6.90901122075163 2.16973125160537e-11 Alcoholism: NPY hsa05321__55 4.96234177971193e-12 DOWN -6.90743669677242 2.18878878030017e-11 Inflammatory bowel disease (IBD): IL4* hsa05166__26 5.36274492193578e-12 DOWN -6.89641502891799 2.35985894808368e-11 HTLV-I infection: NFATC1 hsa03320__25 5.42247135978951e-12 DOWN -6.89484050493878 2.37501717600105e-11 PPAR signaling pathway: EHHADH hsa04330__19 5.42247135978951e-12 DOWN -6.89484050493878 2.37501717600105e-11 Notch signaling pathway: DTX2 hsa05168__29 5.4828496506441e-12 UP 6.89326598095958 2.39587778920006e-11 Herpes simplex infection: IKBKG hsa04210__69 5.6679656353155e-12 DOWN -6.88854240902196 2.47102260528024e-11 Apoptosis: PTPN13 hsa04360__58 5.73102169870571e-12 UP 6.88696788504276 2.49272911385834e-11 Axon guidance: PLXNC1 hsa04115__25 5.99019369781925e-12 DOWN -6.88066978912594 2.59943971321071e-11 p53 signaling pathway: CD82 hsa04660__41 46 6.40062515580988e-12 DOWN -6.87122264525071 2.77114623681262e-11 T cell receptor signaling pathway: GRAP2 LCP2 hsa04925__18 6.61605180942617e-12 DOWN -6.86649907331309 2.85783019538202e-11 Aldosterone synthesis and secretion: PDE2A hsa04973__5 7.38672475138937e-12 UP 6.85075383352104 3.18340729538088e-11 Carbohydrate digestion and absorption: SLC2A5 hsa04726__72 7.4684660111494e-12 UP 6.84917930954184 3.21126948168186e-11 Serotonergic synapse: KCNJ3 hsa05205__220 7.63461647573476e-12 DOWN -6.84603026158342 3.27521560682776e-11 Proteoglycans in cancer: FAS hsa05321__75 7.71904457857721e-12 DOWN -6.84445573760422 3.30389174559148e-11 Inflammatory bowel disease (IBD): IL10 hsa04810__26 80 9.10084395811377e-12 DOWN -6.82083787791615 3.88647404483995e-11 Regulation of actin cytoskeleton: PFN3 ACTB hsa04211__51 9.30249539022878e-12 UP 6.81768882995773 3.96358023542854e-11 Longevity regulating pathway - mammal: NFKB1 hsa04621__34 35 9.40495619512412e-12 DOWN -6.81611430597853 3.9981702919996e-11 NOD-like receptor signaling pathway: CASP1 PYCARD hsa04022__39 9.61320572070696e-12 DOWN -6.81296525802012 4.07747484180776e-11 cGMP-PKG signaling pathway: KCNJ8 hsa04742__49 1.14500622339066e-11 UP 6.78777287435284 4.84564570664652e-11 Taste transduction: HTR1A hsa04066__58 1.20915935363338e-11 DOWN -6.77990025445681 5.09419377909666e-11 HIF-1 signaling pathway: EDN1 hsa04110__48 1.20915935363338e-11 UP 6.77990025445681 5.09419377909666e-11 Cell cycle: RB1* hsa05142__49 1.36294129616872e-11 DOWN -6.76258049068556 5.72923198098662e-11 Chagas disease (American trypanosomiasis): ADCY1 hsa04973__36 1.39288996400127e-11 DOWN -6.75943144272715 5.84205411240712e-11 Carbohydrate digestion and absorption: SLC2A2 hsa04014__66 1.45473355984921e-11 UP 6.75313334681033 6.08784935179658e-11 Ras signaling pathway: RAF1* hsa04115__27 1.50287326755979e-11 DOWN -6.74840977487271 6.27533082165522e-11 p53 signaling pathway: THBS1 hsa04970__45 1.53581348639948e-11 DOWN -6.7452607269143 6.39865530142933e-11 Salivary secretion: KCNMA1 hsa05211__23 1.56949323801282e-11 UP 6.74211167895589 6.5245083943055e-11 Renal cell carcinoma: PDGFB hsa05133__60 1.80660556900955e-11 DOWN -6.72164286722623 7.49362442421399e-11 Pertussis: C5 hsa05142__18 1.99095545683152e-11 DOWN -6.70747215141338 8.24009978719479e-11 Chagas disease (American trypanosomiasis): FOS hsa05132__48 2.17019762455475e-11 DOWN -6.69487595957974 8.96220073964478e-11 Salmonella infection: KLC3 hsa05205__183 2.24140854047859e-11 UP 6.69015238764213 9.23597949026158e-11 Proteoglycans in cancer: VEGFA* hsa04062__35 36 37 2.57734251026019e-11 DOWN -6.66968357591246 1.05969946975468e-10 Chemokine signaling pathway: PARD3 PRKCZ TIAM1 hsa04010__65 2.80806566556169e-11 UP 6.65708738407882 1.14953276374519e-10 MAPK signaling pathway: ELK4 hsa04740__10 2.80806566556169e-11 UP 6.65708738407882 1.14953276374519e-10 Olfactory transduction: ANO2 hsa04921__65 2.83829087779652e-11 DOWN -6.65551286009962 1.15938012160427e-10 Oxytocin signaling pathway: TRPM2 hsa04066__44 2.89969967554322e-11 DOWN -6.65236381214121 1.18189494367586e-10 HIF-1 signaling pathway: GAPDH hsa04710__7 3.09183317560273e-11 DOWN -6.64291666826598 1.25747933700379e-10 Circadian rhythm: PER1 hsa04725__25 3.19251778785763e-11 UP 6.63819309632836 1.292832095557e-10 Cholinergic synapse: CACNA1A hsa05231__60 3.19251778785763e-11 UP 6.63819309632836 1.292832095557e-10 Choline metabolism in cancer: PRKCA hsa04530__14 20 43 3.22678705909767e-11 UP 6.63661857234916 1.30389954495581e-10 Tight junction: CTNNA1 ACTB ACTN4 hsa05030__78 3.29640909052312e-11 DOWN -6.63346952439075 1.32917439508432e-10 Cocaine addiction: GRIA2 hsa05161__66 67 3.33176927493856e-11 UP 6.63189500041154 1.34055556051596e-10 Hepatitis B: NFKB1 NFKBIA hsa05222__34 3.40360682121026e-11 UP 6.62874595245313 1.36653359338762e-10 Small cell lung cancer: CCND1 hsa04066__48 3.62833572802553e-11 DOWN -6.6192988085779 1.45365518826439e-10 HIF-1 signaling pathway: PFKFB3 hsa04750__53 4.3468780677766e-11 DOWN -6.59253190093142 1.73782635943665e-10 Inflammatory mediator regulation of TRP channels: TRPM8 hsa05130__28 4.58351706800156e-11 UP 6.58465928103539 1.82854109782907e-10 Pathogenic Escherichia coli infection: ROCK1 hsa05211__22 4.63233509134317e-11 DOWN -6.58308475705619 1.84410119420208e-10 Renal cell carcinoma: TGFA hsa04340__17 4.73150205301268e-11 UP 6.57993570909778 1.87959669294098e-10 Hedgehog signaling pathway: SMO hsa05152__20 4.88412581030811e-11 DOWN -6.57521213716016 1.93207015061825e-10 Tuberculosis: FCGR1A hsa04022__59 4.88415817745432e-11 UP 6.57521213716016 1.93207015061825e-10 cGMP-PKG signaling pathway: NPPB hsa04910__32 5.48623449944908e-11 UP 6.55789237338891 2.1656795429548e-10 Insulin signaling pathway: EIF4E hsa04920__40 5.662663570526e-11 DOWN -6.55316880145129 2.23063833312754e-10 Adipocytokine signaling pathway: PPARGC1A hsa05161__100 5.90655865358586e-11 UP 6.54687070553447 2.32184596445352e-10 Hepatitis B: MMP9* hsa04010__64 5.96912020728982e-11 UP 6.54529618155527 2.34154005626254e-10 MAPK signaling pathway: DDIT3 hsa04540__22 6.35828747756977e-11 DOWN -6.53584903768004 2.48900461882367e-10 Gap junction: C00547 hsa05200__129 130 6.70153936655719e-11 UP 6.52797641778401 2.61248806426576e-10 Pathways in cancer: CTBP1 HDAC1 hsa05220__12 13 6.70153936655719e-11 UP 6.52797641778401 2.61248806426576e-10 Chronic myeloid leukemia: HDAC1 CTBP1 hsa04064__97 6.84383955969026e-11 DOWN -6.5248273698256 2.65693688691281e-10 NF-kappa B signaling pathway: PLCG2 hsa05221__6 6.84383955969026e-11 UP 6.5248273698256 2.65693688691281e-10 Acute myeloid leukemia: CEBPA hsa04610__44 7.13729120102384e-11 DOWN -6.51852927390878 2.76514848798429e-10 Complement and coagulation cascades: C3 hsa04620__40 8.26489350401552e-11 DOWN -6.49648593819991 3.19541870247843e-10 Toll-like receptor signaling pathway: CCL5 hsa04360__31 8.98554166746222e-11 UP 6.48388974636627 3.45980180187736e-10 Axon guidance: CDC42* hsa05161__31 8.98554166746222e-11 UP 6.48388974636627 3.45980180187736e-10 Hepatitis B: ELK1 hsa04530__5 15 9.36855182061186e-11 DOWN -6.47759165044945 3.5998995646073e-10 Tight junction: IGSF5 MPDZ hsa05030__76 9.76750852424274e-11 DOWN -6.47129355453263 3.7455405136841e-10 Cocaine addiction: PDYN hsa05214__52 9.97316817184326e-11 UP 6.46814450657422 3.81661568124104e-10 Glioma: E2F1* hsa04923__43 1.00775795032332e-10 DOWN -6.46656998259502 3.84092736036009e-10 Regulation of lipolysis in adipocytes: C00219 hsa05132__6 1.00775795032332e-10 DOWN -6.46656998259502 3.84092736036009e-10 Salmonella infection: NFKB1 hsa04919__103 1.12990171395228e-10 DOWN -6.44925021882376 4.29774356379825e-10 Thyroid hormone signaling pathway: CCND1 hsa04550__67 1.16565179029367e-10 DOWN -6.44452664688615 4.42476709891275e-10 Signaling pathways regulating pluripotency of stem cells: MYC* hsa04621__21 31 41 1.20250673574312e-10 DOWN -6.43980307494853 4.55546402512362e-10 NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1 hsa05160__55 1.2404998489669e-10 UP 6.43507950301092 4.68993806078232e-10 Hepatitis C: MAPK14 hsa04921__76 1.29298720211053e-10 DOWN -6.4287814070941 4.87856014611582e-10 Oxytocin signaling pathway: CDKN1A hsa04261__23 1.32003868506657e-10 DOWN -6.42563235913568 4.9706466718238e-10 Adrenergic signaling in cardiomyocytes: SLC9A1 hsa04724__13 1.36156125262922e-10 UP 6.42090878719807 5.11674718738059e-10 Glutamatergic synapse: GRM5 hsa04725__64 1.37581132125198e-10 DOWN -6.41933426321886 5.15997898729035e-10 Cholinergic synapse: KCNJ3 hsa04620__12 1.46381299190504e-10 DOWN -6.40988711934363 5.47909285217046e-10 Toll-like receptor signaling pathway: NFKB1 hsa04724__66 1.63965596025099e-10 UP 6.39256735557238 6.12507663879046e-10 Glutamatergic synapse: PLA2G4B hsa04110__46 1.65662892887452e-10 UP 6.39099283159317 6.16397179674303e-10 Cell cycle: RB1 hsa04620__39 1.65662892887452e-10 DOWN -6.39099283159317 6.16397179674303e-10 Toll-like receptor signaling pathway: IL6 hsa04976__59 1.78034145586101e-10 DOWN -6.37997116373874 6.59814910367424e-10 Bile secretion: ABCB4 hsa05221__27 1.78034145586101e-10 DOWN -6.37997116373874 6.59814910367424e-10 Acute myeloid leukemia: PIM2 hsa05212__31 1.89352911822009e-10 UP 6.37052401986351 7.0038212856999e-10 Pancreatic cancer: RAC1* hsa05200__188 1.93279794425256e-10 DOWN -6.3673749719051 7.1350242382133e-10 Pathways in cancer: KLK3 hsa04213__54 2.01373699398745e-10 DOWN -6.36107687598828 7.41923884647534e-10 Longevity regulating pathway - multiple species: SOD2* hsa05152__126 2.03448357702495e-10 UP 6.35950235200907 7.48100712569447e-10 Tuberculosis: NOS2 hsa05200__203 2.05543891704702e-10 DOWN -6.35792782802987 7.54330024439716e-10 Pathways in cancer: TGFA* hsa04064__113 2.09798407995018e-10 DOWN -6.35477878007146 7.68442901798516e-10 NF-kappa B signaling pathway: CFLAR hsa04950__13 2.14138910312387e-10 UP 6.35162973211305 7.82815199371548e-10 Maturity onset diabetes of the young: INS hsa04310__35 2.18567092567686e-10 DOWN -6.34848068415464 7.97451586280935e-10 Wnt signaling pathway: JUN hsa04742__8 2.25374070301685e-10 DOWN -6.34375711221702 8.20693562203228e-10 Taste transduction: PLCB2 hsa04151__24 2.4707649089869e-10 DOWN -6.32958639640418 8.97982062666611e-10 PI3K-Akt signaling pathway: MYC hsa04933__43 2.76380647455994e-10 UP 6.31226663263292 1.00254678874481e-09 AGE-RAGE signaling pathway in diabetic complications: CASP3 hsa04261__34 2.84944871153866e-10 DOWN -6.30754306069531 1.03162121945687e-09 Adrenergic signaling in cardiomyocytes: AKT3 hsa04010__62 3.21868839970522e-10 UP 6.28864877294485 1.16306067366271e-09 MAPK signaling pathway: MEF2C hsa04015__100 101 48 3.35185023354582e-10 DOWN -6.28235067702803 1.20885347194484e-09 Rap1 signaling pathway: PRKCI PARD6A PARD3 hsa04064__50 3.42043328187335e-10 DOWN -6.27920162906962 1.23122493039081e-09 NF-kappa B signaling pathway: NFKBIA* hsa04261__39 3.74639308051364e-10 DOWN -6.26503091325677 1.34341080119945e-09 Adrenergic signaling in cardiomyocytes: SCN1B hsa04917__33 3.74639308051364e-10 UP 6.26503091325677 1.34341080119945e-09 Prolactin signaling pathway: CSN2 hsa05212__14 3.7844306197752e-10 DOWN -6.26345638927757 1.35446573991573e-09 Pancreatic cancer: MAPK1 hsa04917__31 3.82284509194757e-10 DOWN -6.26188186529836 1.36561329425275e-09 Prolactin signaling pathway: GALT hsa03320__20 3.90080768924962e-10 DOWN -6.25873281733995 1.39081928806452e-09 PPAR signaling pathway: SCP2 hsa05164__31 32 33 3.94029187392724e-10 DOWN -6.25715829336075 1.39961938526283e-09 Influenza A: NLRP3 PYCARD CASP1 hsa05130__55 3.94038666739774e-10 UP 6.25715829336075 1.39961938526283e-09 Pathogenic Escherichia coli infection: ACTB hsa04660__56 4.35823745716849e-10 DOWN -6.2414130535687 1.54220869717883e-09 T cell receptor signaling pathway: CD3E hsa05161__130 4.35823745716849e-10 DOWN -6.2414130535687 1.54220869717883e-09 Hepatitis B: FASLG* hsa05215__43 4.49173568166827e-10 DOWN -6.23668948163108 1.58646077929599e-09 Prostate cancer: C05981 hsa05321__46 5.60119300847267e-10 DOWN -6.20204995408857 1.97460443957226e-09 Inflammatory bowel disease (IBD): IFNG* hsa04210__50 5.65751407546309e-10 UP 6.20047543010937 1.99072452205902e-09 Apoptosis: SPTA1 hsa04720__32 5.94751278834429e-10 UP 6.19260281021334 2.08885542603718e-09 Long-term potentiation: ITPR1 hsa04152__54 6.00722883687835e-10 DOWN -6.19102828623414 2.10589234785344e-09 AMPK signaling pathway: SLC2A4* hsa04933__63 6.12842114835328e-10 DOWN -6.18787923827573 2.14437678542939e-09 AGE-RAGE signaling pathway in diabetic complications: SELE hsa04024__123 6.18990861805166e-10 DOWN -6.18630471429652 2.16186585377678e-09 cAMP signaling pathway: PAK1 hsa04724__51 6.77107470460274e-10 UP 6.17213399848368 2.36045442856188e-09 Glutamatergic synapse: ADRBK1 hsa04330__11 6.8388443430461e-10 DOWN -6.17055947450447 2.37966454084882e-09 Notch signaling pathway: PTCRA hsa04917__75 6.90727553451881e-10 DOWN -6.16898495052527 2.3990334065362e-09 Prolactin signaling pathway: CCND1** hsa04115__50 6.97637456565767e-10 DOWN -6.16741042654606 2.41410825209406e-09 p53 signaling pathway: RCHY1 hsa04921__67 6.97637456565767e-10 DOWN -6.16741042654606 2.41410825209406e-09 Oxytocin signaling pathway: RYR1 hsa05164__90 7.33211143960752e-10 UP 6.15953780665004 2.53254363879091e-09 Influenza A: MAPK1 hsa04024__60 8.09745779356917e-10 DOWN -6.14379256685799 2.79176572369109e-09 cAMP signaling pathway: PDE3A hsa04152__63 8.17814621748604e-10 UP 6.14221804287878 2.81442064883814e-09 AMPK signaling pathway: PPARG hsa04010__118 9.58099630746568e-10 DOWN -6.1170256592115 3.29116856704351e-09 MAPK signaling pathway: JUN hsa04950__18 1.00656458191114e-09 DOWN -6.10915303931548 3.43879063529277e-09 Maturity onset diabetes of the young: SLC2A2 hsa05030__77 1.00656458191114e-09 DOWN -6.10915303931548 3.43879063529277e-09 Cocaine addiction: BDNF hsa05160__58 1.00656458191114e-09 UP 6.10915303931548 3.43879063529277e-09 Hepatitis C: EIF3E hsa05215__12 1.04705017282109e-09 DOWN -6.10285494339866 3.57061211384906e-09 Prostate cancer: KLK3 hsa05150__1 2 3 1.05741709149153e-09 DOWN -6.10128041941945 3.59943245455179e-09 Staphylococcus aureus infection: CFD C3 CFB hsa05231__18 1.13284035965577e-09 UP 6.09025875156502 3.84919897973452e-09 Choline metabolism in cancer: CHKA hsa03320__37 1.16674402056877e-09 DOWN -6.0855351796274 3.95724190369805e-09 PPAR signaling pathway: HMGCS2 hsa04810__35 81 80 1.31254626977074e-09 DOWN -6.06664089187694 4.44373773134996e-09 Regulation of actin cytoskeleton: MYL12B MYH9 ACTB hsa04710__11 1.32546807417596e-09 UP 6.06506636789774 4.4794145888069e-09 Circadian rhythm: CRY1 hsa04310__36 1.36498196196992e-09 DOWN -6.06034279596012 4.60466985016425e-09 Wnt signaling pathway: MYC hsa05142__29 1.4194574611418e-09 UP 6.0540447000433 4.77985765140762e-09 Chagas disease (American trypanosomiasis): NOS2 hsa04012__48 1.44748412474676e-09 DOWN -6.05089565208489 4.84816875293968e-09 ErbB signaling pathway: CAMK2A hsa04510__26 4 5 1.44748412474676e-09 UP 6.05089565208489 4.84816875293968e-09 Focal adhesion: ACTN4 ITGB1 ITGA11 hsa04620__66 1.44748412474676e-09 DOWN -6.05089565208489 4.84816875293968e-09 Toll-like receptor signaling pathway: CASP8 hsa04510__6 4 5 1.46169898759644e-09 UP 6.04932112810569 4.87838791775081e-09 Focal adhesion: FLNA ITGB1 ITGA11 hsa04925__34 1.46169898759644e-09 DOWN -6.04932112810569 4.87838791775081e-09 Aldosterone synthesis and secretion: STAR hsa04064__131 1.56508334930383e-09 DOWN -6.03829946025125 5.20494090856974e-09 NF-kappa B signaling pathway: CCL4L1 hsa04620__87 1.56508334930383e-09 DOWN -6.03829946025125 5.20494090856974e-09 Toll-like receptor signaling pathway: CCL4L1 hsa04921__28 1.67558124645144e-09 UP 6.02727779239682 5.56257449131142e-09 Oxytocin signaling pathway: EEF2 hsa04014__76 1.72523177358136e-09 UP 6.0225542204592 5.71730247364968e-09 Ras signaling pathway: RALBP1* hsa04917__48 1.79366779230278e-09 UP 6.01625612454238 5.93362989742415e-09 Prolactin signaling pathway: CCND2 hsa04015__82 1.81118587651662e-09 DOWN -6.01468160056317 5.98105142702061e-09 Rap1 signaling pathway: ITGA2B hsa05205__369 1.9198488225393e-09 UP 6.00523445668794 6.32876480272165e-09 Proteoglycans in cancer: HOXD10 hsa04064__115 1.95746179418069e-09 DOWN -6.00208540872953 6.44145483584152e-09 NF-kappa B signaling pathway: XIAP hsa04024__91 1.976536547644e-09 DOWN -6.00051088475033 6.49285344934105e-09 cAMP signaling pathway: GRIA1 hsa04066__89 1.99579234851431e-09 DOWN -5.99893636077112 6.544666357519e-09 HIF-1 signaling pathway: CDKN1A hsa04390__18 2.07465965521754e-09 UP 5.99263826485431 6.79143813964071e-09 Hippo signaling pathway: MOB1A hsa04550__17 2.13579447866052e-09 DOWN -5.98791469291669 6.97940491374455e-09 Signaling pathways regulating pluripotency of stem cells: AKT3 hsa04510__20 4 5 2.15656005775766e-09 UP 5.98634016893748 7.03502838285876e-09 Focal adhesion: VASP ITGB1 ITGA11 hsa04921__48 2.3075271625007e-09 DOWN -5.97531850108305 7.51446020509327e-09 Oxytocin signaling pathway: PRKAG2 hsa04270__48 2.37533433675064e-09 DOWN -5.97059492914543 7.70855478195932e-09 Vascular smooth muscle contraction: KCNMB2* hsa05220__4 2.37533433675064e-09 UP 5.97059492914543 7.70855478195932e-09 Chronic myeloid leukemia: PTPN11 hsa05152__78 2.39836505161479e-09 DOWN -5.96902040516623 7.76987574480032e-09 Tuberculosis: IL1A hsa03320__43 2.44508080379907e-09 UP 5.96587135720782 7.90758490591817e-09 PPAR signaling pathway: ILK hsa04540__18 19 2.49268237333045e-09 UP 5.96272230924941 8.04768072076961e-09 Gap junction: GJA1 GJA1*** hsa04623__25 2.51682042695899e-09 DOWN -5.9611477852702 8.11167338294331e-09 Cytosolic DNA-sensing pathway: NFKB1* hsa05014__51 2.56573933494978e-09 UP 5.95799873731179 8.25517844241548e-09 Amyotrophic lateral sclerosis (ALS): DERL1 hsa05120__50 2.61566953790843e-09 DOWN -5.95484968935338 8.4014411311623e-09 Epithelial cell signaling in Helicobacter pylori infection: EGFR hsa05205__233 234 2.71829578174938e-09 UP 5.94855159343656 8.71617367560936e-09 Proteoglycans in cancer: ITGA2 C00925 hsa04010__87 2.7445588287223e-09 DOWN -5.94697706945736 8.78539359313321e-09 MAPK signaling pathway: STK3 hsa04921__11 2.90740466795647e-09 DOWN -5.93752992558213 9.29083906647995e-09 Oxytocin signaling pathway: PRKACA hsa05132__55 2.93544510776229e-09 DOWN -5.93595540160292 9.3645184337612e-09 Salmonella infection: IL18 hsa04210__106 3.05026366159749e-09 UP 5.9296573056861 9.6978771914411e-09 Apoptosis: TUBA1B hsa04510__24 69 3.05026366159749e-09 UP 5.9296573056861 9.6978771914411e-09 Focal adhesion: ZYX ACTB hsa04020__8 3.07964466341728e-09 DOWN -5.9280827817069 9.77475054486665e-09 Calcium signaling pathway: PDE1A hsa04066__64 3.13923563576197e-09 DOWN -5.92493373374849 9.94708897065216e-09 HIF-1 signaling pathway: LTBR hsa04024__59 3.19994873621981e-09 DOWN -5.92178468579008 1.01223967598603e-08 cAMP signaling pathway: MLLT4 hsa04151__110 3.35677633513422e-09 UP 5.91391206589405 1.06006432499449e-08 PI3K-Akt signaling pathway: BCL2** hsa04915__66 3.48760272710228e-09 DOWN -5.90761396997723 1.0995311282257e-08 Estrogen signaling pathway: AKT3* hsa04722__46 3.58896675131937e-09 DOWN -5.90289039803962 1.12959271787757e-08 Neurotrophin signaling pathway: ATF4* hsa04066__60 3.62338773767436e-09 DOWN -5.90131587406041 1.13851932426256e-08 HIF-1 signaling pathway: NOS3 hsa04728__70 73 3.69319645933034e-09 DOWN -5.898166826102 1.15851688599027e-08 Dopaminergic synapse: KIF5A GRIA1 hsa04064__130 3.87349531855734e-09 DOWN -5.89029420620598 1.21304961726154e-08 NF-kappa B signaling pathway: TNF* hsa04550__69 4.02387642900339e-09 DOWN -5.88399611028916 1.2538745953727e-08 Signaling pathways regulating pluripotency of stem cells: ID1 hsa05145__33 4.02387642900339e-09 DOWN -5.88399611028916 1.2538745953727e-08 Toxoplasmosis: STAT3 hsa05169__125 4.02387642900339e-09 DOWN -5.88399611028916 1.2538745953727e-08 Epstein-Barr virus infection: STAT3 hsa04933__25 4.10118287751081e-09 DOWN -5.88084706233075 1.27584811702696e-08 AGE-RAGE signaling pathway in diabetic complications: IL1A hsa04725__53 4.46681428443367e-09 UP 5.8666763465179 1.38729653561171e-08 Cholinergic synapse: CHRNA7 hsa04960__27 4.59629554895151e-09 DOWN -5.86195277458029 1.42515500601978e-08 Aldosterone-regulated sodium reabsorption: KCNJ1 hsa05034__99 4.6842822037189e-09 DOWN -5.85880372662188 1.45004386503918e-08 Alcoholism: PDYN hsa04064__114 4.95819006706774e-09 DOWN -5.84935658274665 1.52979296157968e-08 NF-kappa B signaling pathway: BCL2A1* hsa05200__201 4.95819006706774e-09 UP 5.84935658274665 1.52979296157968e-08 Pathways in cancer: PDGFB hsa05211__49 5.10092643370433e-09 DOWN -5.84463301080903 1.57125258507056e-08 Renal cell carcinoma: TGFA* hsa05110__50 5.34769531407601e-09 UP 5.83676039091301 1.64456947547444e-08 Vibrio cholerae infection: ACTB hsa04924__49 5.50138342681203e-09 DOWN -5.83203681897539 1.68906853904899e-08 Renin secretion: PDE1A hsa04152__35 5.87674453086719e-09 DOWN -5.82101515112096 1.80137079502438e-08 AMPK signaling pathway: PFKFB1 hsa04725__43 6.21821587277675e-09 UP 5.81156800724573 1.90293609526833e-08 Cholinergic synapse: CREB3 hsa05152__120 6.45650457244191e-09 DOWN -5.80526991132891 1.97264586855583e-08 Tuberculosis: TGFB1 hsa04022__45 6.51745072789874e-09 DOWN -5.8036953873497 1.98803407755223e-08 cGMP-PKG signaling pathway: CREB3 hsa05200__76 7.09174616029462e-09 UP 5.78952467153686 2.15970681283527e-08 Pathways in cancer: RAC1 hsa04917__56 7.29389384306427e-09 UP 5.78480109959924 2.21767419597375e-08 Prolactin signaling pathway: LHCGR hsa04920__9 7.50164057186085e-09 DOWN -5.78007752766163 2.27715389895421e-08 Adipocytokine signaling pathway: G6PC hsa04976__38 7.57215958332235e-09 DOWN -5.77850300368242 2.28747393200365e-08 Bile secretion: ABCC2 hsa05100__33 7.57215958332235e-09 UP 5.77850300368242 2.28747393200365e-08 Bacterial invasion of epithelial cells: DNM1 hsa05215__34 7.57215958332235e-09 UP 5.77850300368242 2.28747393200365e-08 Prostate cancer: BAD hsa04970__32 7.86073747701073e-09 DOWN -5.7722049077656 2.37083879924609e-08 Salivary secretion: RYR3 hsa04210__74 8.08416051792883e-09 UP 5.76748133582799 2.43431692519043e-08 Apoptosis: BAX* hsa04923__52 53 8.47032370395274e-09 DOWN -5.75960871593196 2.54651811835635e-08 Regulation of lipolysis in adipocytes: PNPLA2 ABHD5* hsa05211__40 8.54968032774476e-09 UP 5.75803419195276 2.56626986195406e-08 Renal cell carcinoma: PAK4 hsa04068__42 8.62975958345216e-09 DOWN -5.75645966797355 2.58617516065496e-08 FoxO signaling pathway: CDKN2D hsa04261__36 9.12577150729389e-09 DOWN -5.74701252409832 2.7261247475684e-08 Adrenergic signaling in cardiomyocytes: MAPK1 hsa04550__60 9.12577150729389e-09 UP 5.74701252409832 2.7261247475684e-08 Signaling pathways regulating pluripotency of stem cells: MAPK14 hsa04933__24 9.38406220597553e-09 DOWN -5.74228895216071 2.79883379127429e-08 AGE-RAGE signaling pathway in diabetic complications: THBD hsa05142__7 9.47100554502897e-09 DOWN -5.7407144281815 2.82028833900308e-08 Chagas disease (American trypanosomiasis): C1QA hsa04670__15 9.56006786904375e-09 UP 5.7391399042023 2.8378508237759e-08 Leukocyte transendothelial migration: PECAM1 hsa05200__197 9.56018931053829e-09 DOWN -5.7391399042023 2.8378508237759e-08 Pathways in cancer: CCND1** hsa05162__27 28 9.73952802048204e-09 DOWN -5.73599085624389 2.8865257335151e-08 Measles: STAT1 IRF9 hsa04520__17 1.02023003886326e-08 DOWN -5.72811823634786 3.01891691814813e-08 Adherens junction: SNAI1 hsa04360__123 1.08862507940413e-08 UP 5.71709656849343 3.21623667327101e-08 Axon guidance: ENAH hsa04024__116 1.14018575868585e-08 DOWN -5.7092239485974 3.36327949854115e-08 cAMP signaling pathway: ACOX1 hsa04151__25 1.19411643623183e-08 DOWN -5.70135132870138 3.51684135372981e-08 PI3K-Akt signaling pathway: CDKN1B hsa05205__284 1.20519617188711e-08 DOWN -5.69977680472217 3.54391800778699e-08 Proteoglycans in cancer: PRKCA* hsa05152__69 1.21637577555552e-08 UP 5.69820228074297 3.57120325354503e-08 Tuberculosis: HLA-DMA hsa04261__52 1.22765611943934e-08 DOWN -5.69662775676376 3.59869867149223e-08 Adrenergic signaling in cardiomyocytes: MAPK14 hsa04115__37 1.26211042513068e-08 DOWN -5.69190418482615 3.69393378320959e-08 p53 signaling pathway: FAS hsa04064__3 1.30951407791937e-08 DOWN -5.68560608890933 3.82671376735691e-08 NF-kappa B signaling pathway: BCL2 hsa04742__55 1.38386125164828e-08 DOWN -5.6761589450341 4.03148468399807e-08 Taste transduction: P2RX3 hsa04360__33 134 1.38387845725319e-08 UP 5.6761589450341 4.03148468399807e-08 Axon guidance: NCK1 PAK4 hsa04012__29 1.40956623616369e-08 DOWN -5.67300989707569 4.09996123490955e-08 ErbB signaling pathway: STAT5A* hsa04550__101 1.43571697480346e-08 DOWN -5.66986084911728 4.16957062697945e-08 Signaling pathways regulating pluripotency of stem cells: ESRRB hsa04151__27 1.44896847364538e-08 DOWN -5.66828632513807 4.20156136107973e-08 PI3K-Akt signaling pathway: FASLG hsa04933__23 1.48943978628823e-08 DOWN -5.66356275320046 4.31226095290537e-08 AGE-RAGE signaling pathway in diabetic complications: F3 hsa05200__218 1.50317262892563e-08 DOWN -5.66198822922125 4.34532518423269e-08 Pathways in cancer: CSF3R* hsa04540__10 1.51702842912042e-08 DOWN -5.66041370524205 4.37864273167014e-08 Gap junction: C00533 hsa05200__183 1.6474426309622e-08 UP 5.6462429894292 4.74776795027295e-08 Pathways in cancer: BMP2 hsa04014__70 1.78871848116403e-08 UP 5.63207227361636 5.14701688530968e-08 Ras signaling pathway: RIN1* hsa03320__10 1.83837327098491e-08 DOWN -5.62734870167874 5.28180944370129e-08 PPAR signaling pathway: PLIN1 hsa05205__81 1.88936545038467e-08 UP 5.62262512974112 5.42002699430962e-08 Proteoglycans in cancer: CTTN hsa05200__184 1.94172987190404e-08 UP 5.61790155780351 5.55328832466923e-08 Pathways in cancer: GLI1 hsa05215__8 1.94172987190404e-08 DOWN -5.61790155780351 5.55328832466923e-08 Prostate cancer: NFKBIA hsa05169__31 1.95949577141459e-08 DOWN -5.61632703382431 5.59558138979942e-08 Epstein-Barr virus infection: MYC hsa04650__39 1.99550226393623e-08 DOWN -5.6131779858659 5.68975531705034e-08 Natural killer cell mediated cytotoxicity: FAS hsa05162__78 2.01374558101094e-08 DOWN -5.61160346188669 5.73307264654478e-08 Measles: FAS hsa04921__56 2.03215078017752e-08 DOWN -5.61002893790748 5.77671908616272e-08 Oxytocin signaling pathway: JUN hsa04922__70 2.10741837967931e-08 DOWN -5.60373084199066 5.98163011392361e-08 Glucagon signaling pathway: PFKFB1 hsa04933__62 2.24569820828356e-08 UP 5.59270917413623 6.36450517852911e-08 AGE-RAGE signaling pathway in diabetic complications: AGER** hsa05205__30 2.2867982897047e-08 DOWN -5.58956012617782 6.47122588306496e-08 Proteoglycans in cancer: FLNA hsa04923__26 27 2.50346850178667e-08 DOWN -5.57381488638577 7.06317382328285e-08 Regulation of lipolysis in adipocytes: PNPLA2 ABHD5 hsa05205__422 2.50349854513378e-08 DOWN -5.57381488638577 7.06317382328285e-08 Proteoglycans in cancer: CD63 hsa04022__44 2.5262337399972e-08 DOWN -5.57224036240656 7.11663148044188e-08 cGMP-PKG signaling pathway: BAD hsa04360__40 139 2.5723067950592e-08 UP 5.56909131444815 7.2355755507728e-08 Axon guidance: UNC5D DCC hsa04360__51 2.76488969128716e-08 DOWN -5.55649512261451 7.76566177866752e-08 Axon guidance: FYN hsa05162__20 2.99827956596854e-08 UP 5.54232440680167 8.40860791709685e-08 Measles: NFKB1 hsa04932__96 3.02536214872054e-08 DOWN -5.54074988282246 8.47191576370475e-08 Non-alcoholic fatty liver disease (NAFLD): IL6* hsa05218__8 3.13608535911981e-08 UP 5.53445178690564 8.76890534194363e-08 Melanoma: CDK4 hsa04114__56 3.22169750720454e-08 DOWN -5.52972821496803 8.9949028470094e-08 Oocyte meiosis: REC8 hsa04722__35 3.30957498018216e-08 DOWN -5.52500464303041 9.22654508570071e-08 Neurotrophin signaling pathway: FOXO3 hsa04950__31 3.33938084829215e-08 UP 5.52343011905121 9.29584683546809e-08 Maturity onset diabetes of the young: NKX6-1* hsa04210__24 3.49235904179271e-08 DOWN -5.51555749915518 9.70731159693566e-08 Apoptosis: CASP10 hsa04611__34 3.58738580068608e-08 DOWN -5.51083392721757 9.95671775404601e-08 Platelet activation: C02198* hsa04150__56 3.61961509590514e-08 UP 5.50925940323836 1.00313521610704e-07 mTOR signaling pathway: EIF4B hsa04360__40 142 3.68491829308988e-08 UP 5.50611035527995 1.01972923014961e-07 Axon guidance: UNC5D PTPN11 hsa04066__88 3.75136349049181e-08 DOWN -5.50296130732154 1.03658999979913e-07 HIF-1 signaling pathway: BCL2 hsa04012__56 3.78502035846534e-08 DOWN -5.50138678334234 1.04435436909785e-07 ErbB signaling pathway: JUN hsa04917__47 3.88775740200207e-08 UP 5.49666321140472 1.07112846896802e-07 Prolactin signaling pathway: INS hsa04916__4 3.9226001685825e-08 DOWN -5.49508868742552 1.07914578576377e-07 Melanogenesis: TYR hsa04210__63 3.99319643141488e-08 DOWN -5.49193963946711 1.09696141734336e-07 Apoptosis: FAS* hsa04670__76 4.25011731872396e-08 DOWN -5.48091797161267 1.16583510100472e-07 Leukocyte transendothelial migration: CDC42 hsa04010__120 4.44337078095631e-08 DOWN -5.47304535171665 1.21706905210159e-07 MAPK signaling pathway: NFATC1 hsa05161__78 4.48303100856945e-08 DOWN -5.47147082773744 1.22614487119389e-07 Hepatitis B: TNF hsa04020__18 4.52299247021355e-08 DOWN -5.46989630375824 1.22814761753158e-07 Calcium signaling pathway: C00002 hsa04020__17 4.52299247021355e-08 DOWN -5.46989630375824 1.22814761753158e-07 Calcium signaling pathway: C00004 hsa04020__15 4.52299247021355e-08 DOWN -5.46989630375824 1.22814761753158e-07 Calcium signaling pathway: C13051 hsa04066__43 4.52303433385766e-08 DOWN -5.46989630375824 1.22814761753158e-07 HIF-1 signaling pathway: PFKL hsa05014__53 4.52303433385766e-08 DOWN -5.46989630375824 1.22814761753158e-07 Amyotrophic lateral sclerosis (ALS): RAB5A hsa04750__40 4.56338362490227e-08 UP 5.46832177977903 1.23731570435662e-07 Inflammatory mediator regulation of TRP channels: C00219 hsa04211__52 5.16626228147689e-08 UP 5.44627844407016 1.39876179061889e-07 Longevity regulating pathway - mammal: PPARG hsa04620__46 5.35224245812e-08 DOWN -5.43998034815334 1.44703073076367e-07 Toll-like receptor signaling pathway: TNF hsa04210__73 5.39974182490497e-08 UP 5.43840582417414 1.45777512772937e-07 Apoptosis: TRAF1 hsa04670__55 5.49596920822801e-08 DOWN -5.43525677621573 1.48162498454238e-07 Leukocyte transendothelial migration: RAC2 hsa04151__73 5.89776726849113e-08 UP 5.42266058438209 1.58539409120098e-07 PI3K-Akt signaling pathway: MAPK1 hsa05211__45 5.89776726849113e-08 DOWN -5.42266058438209 1.58539409120098e-07 Renal cell carcinoma: ETS1 hsa04270__17 6.10919795853897e-08 DOWN -5.41636248846527 1.63988328058496e-07 Vascular smooth muscle contraction: ITPR1 hsa04150__33 6.49700086777466e-08 UP 5.40534082061083 1.7414928146289e-07 mTOR signaling pathway: RPS6 hsa04024__21 6.55431230470626e-08 DOWN -5.40376629663163 1.75435225363861e-07 cAMP signaling pathway: AKT3 hsa05200__209 6.78849494826808e-08 DOWN -5.39746820071481 1.81444978773766e-07 Pathways in cancer: FIGF** hsa05205__400 7.40996613146137e-08 UP 5.38172296092276 1.97774522173521e-07 Proteoglycans in cancer: ITGA2* hsa04972__39 7.74102332810267e-08 DOWN -5.37385034102673 2.0631748700007e-07 Pancreatic secretion: KCNMA1* hsa04722__70 7.80893252908676e-08 UP 5.37227581704753 2.07832637707564e-07 Neurotrophin signaling pathway: ZNF274 hsa04670__73 8.01613976045049e-08 DOWN -5.36755224510991 2.13045638046485e-07 Leukocyte transendothelial migration: MYL12B* hsa04914__15 8.22866689315225e-08 UP 5.3628286731723 2.18077081695812e-07 Progesterone-mediated oocyte maturation: ANAPC10 hsa04921__77 8.22866689315225e-08 DOWN -5.3628286731723 2.18077081695812e-07 Oxytocin signaling pathway: KCNJ3 hsa04530__20 62 9.21436992103146e-08 UP 5.34235986144263 2.43856353262227e-07 Tight junction: ACTB SHROOM1 hsa05150__48 9.29475682003465e-08 DOWN -5.34078533746343 2.456378068192e-07 Staphylococcus aureus infection: C3AR1 hsa05169__11 9.80585681103225e-08 UP 5.10460674058267 2.58780968369798e-07 Epstein-Barr virus infection: HLA-A hsa04015__17 1.022504733539e-07 DOWN -5.32346557369217 2.69465132443166e-07 Rap1 signaling pathway: ACTB hsa04261__20 1.16400093870968e-07 DOWN -5.2998477140041 3.06324616783682e-07 Adrenergic signaling in cardiomyocytes: ATP1B4 hsa05016__52 1.37061042234992e-07 UP 5.2699317583992 3.60192585118251e-07 Huntington's disease: CASP3 hsa05031__8 1.38240880030137e-07 DOWN -5.26835723442 3.62785773151715e-07 Amphetamine addiction: DRD1 hsa05215__22 1.41838115553127e-07 DOWN -5.26363366248238 3.71706860703382e-07 Prostate cancer: C16038 hsa04020__7 1.48045560856382e-07 DOWN -5.25576104258636 3.87433995611619e-07 Calcium signaling pathway: ADCY1 hsa05219__21 1.50599733856775e-07 UP 5.25261199462795 3.93570097241837e-07 Bladder cancer: RB1 hsa04728__24 1.53194208576443e-07 UP 5.24946294666954 3.99794330437689e-07 Dopaminergic synapse: SLC6A3 hsa04510__23 4 5 1.68271161724527e-07 UP 5.23214318289828 4.37924533075328e-07 Focal adhesion: TLN1 ITGB1 ITGA11 hsa05321__19 1.68271161724527e-07 DOWN -5.23214318289828 4.37924533075328e-07 Inflammatory bowel disease (IBD): TNF hsa03320__45 1.69710596718711e-07 UP 5.23056865891907 4.40450568003394e-07 PPAR signaling pathway: PDPK1 hsa04210__75 1.69710596718711e-07 UP 5.23056865891907 4.40450568003394e-07 Apoptosis: BAK1* hsa05222__44 1.72625267007073e-07 UP 5.22741961096067 4.47397071319022e-07 Small cell lung cancer: RB1 hsa04919__29 1.83212621542193e-07 DOWN -5.21639794310623 4.74182528757274e-07 Thyroid hormone signaling pathway: HIF1A hsa04261__72 1.89541554612482e-07 DOWN -5.21009984718941 4.89888007038314e-07 Adrenergic signaling in cardiomyocytes: ATP2B1 hsa05223__24 1.94426413743929e-07 DOWN -5.20537627525179 5.0182312008907e-07 Non-small cell lung cancer: STK4 hsa04020__42 1.96081575194277e-07 DOWN -5.20380175127259 5.04708602452118e-07 Calcium signaling pathway: MYLK4 hsa04330__12 1.96081575194277e-07 DOWN -5.20380175127259 5.04708602452118e-07 Notch signaling pathway: HES1 hsa03320__39 2.01129183002646e-07 UP 5.19907817933497 5.16992797348799e-07 PPAR signaling pathway: MMP1 hsa05020__62 2.02839455580285e-07 DOWN -5.19750365535577 5.19966353390662e-07 Prion diseases: NOTCH1 hsa05164__24 2.02839455580285e-07 DOWN -5.19750365535577 5.19966353390662e-07 Influenza A: IRF7 hsa05145__4 5 2.06302266258441e-07 DOWN -5.19435460739736 5.28122558991296e-07 Toxoplasmosis: MAP3K7 TAB1 hsa05166__136 139 2.09822176089701e-07 UP 5.19120555943895 5.36402542683739e-07 HTLV-I infection: TP53 TBPL2 hsa04115__52 53 2.13400091115757e-07 UP 5.18805651148054 5.44808113052319e-07 p53 signaling pathway: CDK4 CCND1 hsa05168__79 2.1521108747492e-07 DOWN -5.18648198750133 5.48686069695215e-07 Herpes simplex infection: EIF2S1 hsa04022__58 2.26392991017343e-07 UP 5.1770348436261 5.7641250693982e-07 cGMP-PKG signaling pathway: MYH7 hsa04015__14 2.40148691942508e-07 DOWN -5.16601317577167 6.09782962378341e-07 Rap1 signaling pathway: MAPK14 hsa05231__34 2.40148691942508e-07 DOWN -5.16601317577167 6.09782962378341e-07 Choline metabolism in cancer: PLD1 hsa04950__5 2.44224961080341e-07 DOWN -5.16286412781326 6.19296493751635e-07 Maturity onset diabetes of the young: GCK hsa04015__18 2.52578963674728e-07 DOWN -5.15656603189644 6.39617079170908e-07 Rap1 signaling pathway: CDH1 hsa05160__37 2.59014793779719e-07 DOWN -5.15184245995882 6.55032028953018e-07 Hepatitis C: STAT3 hsa04622__11 2.88840963356436e-07 UP 5.13137364822916 7.29478723315516e-07 RIG-I-like receptor signaling pathway: IRF7 hsa04064__2 2.912669911909e-07 DOWN -5.12979912424995 7.34618357647922e-07 NF-kappa B signaling pathway: BCL2L1 hsa04919__44 3.03695285196153e-07 UP 5.12192650435393 7.64937588315779e-07 Thyroid hormone signaling pathway: PFKFB2 hsa04713__14 3.24652439828874e-07 UP 5.10933031252029 8.16629095633807e-07 Circadian entrainment: PRKCA hsa04666__40 3.30105985476244e-07 UP 5.10618126456188 8.29236827152223e-07 Fc gamma R-mediated phagocytosis: PLA2G6 hsa05030__80 81 3.35647917007888e-07 DOWN -5.10303221660347 8.4203262491031e-07 Cocaine addiction: GRIN3A DLG4 hsa04010__63 3.41279611051266e-07 UP 5.09988316864506 8.53880677983127e-07 MAPK signaling pathway: MAX hsa04380__32 3.41279611051266e-07 DOWN -5.09988316864506 8.53880677983127e-07 Osteoclast differentiation: AKT3 hsa05200__66 3.4412955480919e-07 DOWN -5.09830864466585 8.59866267934133e-07 Pathways in cancer: CCND1 hsa04151__105 62 3.47002464736366e-07 UP 5.09673412068665 8.65893268578528e-07 PI3K-Akt signaling pathway: CCND1 CDK2 hsa05205__318 3.89736710766509e-07 UP 5.07469078497778 9.71240423780198e-07 Proteoglycans in cancer: HSPB2 hsa04064__132 3.96241696100901e-07 DOWN -5.07154173701937 9.86143241024626e-07 NF-kappa B signaling pathway: VCAM1 hsa04014__103 4.19844383321713e-07 UP 5.06052006916493 1.04350211145701e-06 Ras signaling pathway: KSR2 hsa05205__238 4.26833449310759e-07 UP 5.05737102120652 1.05947166612274e-06 Proteoglycans in cancer: ITGAV* hsa05215__9 4.30369942539745e-07 UP 5.05579649722732 1.06684053038546e-06 Prostate cancer: CDKN1B hsa04742__46 4.4113935522781e-07 DOWN -5.0510729252897 1.09209597954289e-06 Taste transduction: P2RY1 hsa04211__62 4.4848067223402e-07 DOWN -5.04792387733129 1.10880945148385e-06 Longevity regulating pathway - mammal: EHMT2 hsa05133__59 4.71185051973317e-07 DOWN -5.03847673345606 1.16341223739535e-06 Pertussis: C3 hsa04662__36 5.07332677678307e-07 DOWN -5.02430601764322 1.24938152209376e-06 B cell receptor signaling pathway: CD79A hsa04921__43 5.07332677678307e-07 DOWN -5.02430601764322 1.24938152209376e-06 Oxytocin signaling pathway: CACNG3 hsa04014__63 5.41697105760708e-07 DOWN -5.01170982580958 1.33226290801619e-06 Ras signaling pathway: TIAM1* hsa05321__94 5.50632724901253e-07 DOWN -5.00856077785117 1.35246913737184e-06 Inflammatory bowel disease (IBD): IL22 hsa04310__34 6.42919399857655e-07 DOWN -4.97864482224627 1.57708296649156e-06 Wnt signaling pathway: FOSL1 hsa04022__71 6.53458927930028e-07 UP 4.97549577428786 1.59876214268297e-06 cGMP-PKG signaling pathway: PPIF hsa04064__4 6.53458927930028e-07 DOWN -4.97549577428786 1.59876214268297e-06 NF-kappa B signaling pathway: BIRC2 hsa04727__49 6.58788402308943e-07 UP 4.97392125030866 1.60970534192263e-06 GABAergic synapse: GABRR3 hsa03320__57 6.80539997422772e-07 DOWN -4.96762315439184 1.66069435734726e-06 PPAR signaling pathway: APOC3 hsa04610__57 7.14469288339174e-07 UP 4.95817601051661 1.74122930322868e-06 Complement and coagulation cascades: PLAUR hsa04340__14 7.68434607700294e-07 DOWN -4.94400529470376 1.87032205682494e-06 Hedgehog signaling pathway: PTCH1 hsa04115__23 8.60262974193806e-07 DOWN -4.92196195899489 2.09111788940513e-06 p53 signaling pathway: PTEN hsa05010__61 9.10053463058168e-07 DOWN -4.91094029114046 2.20928999623553e-06 Alzheimer's disease: GAPDH hsa04668__47 1.05115661323256e-06 DOWN -4.88259885951477 2.54854616292127e-06 TNF signaling pathway: CASP7 hsa04210__64 1.10270508648649e-06 DOWN -4.87315171563954 2.67008100194345e-06 Apoptosis: TNFRSF10D* hsa04213__2 1.11152967855755e-06 DOWN -4.87157719166033 2.68798489833929e-06 Longevity regulating pathway - multiple species: RPS6KB1 hsa05034__61 1.12938317604491e-06 DOWN -4.86842814370192 2.72764908456091e-06 Alcoholism: CRH hsa04666__20 1.13841308659937e-06 DOWN -4.86685361972272 2.74592835650863e-06 Fc gamma R-mediated phagocytosis: PLA2G4B hsa04151__35 1.20359596672831e-06 DOWN -4.85583195186828 2.89943182241346e-06 PI3K-Akt signaling pathway: CCND1 hsa04917__71 1.2131960035989e-06 DOWN -4.85425742788908 2.91881599329364e-06 Prolactin signaling pathway: CCND1* hsa04010__57 1.23261754886587e-06 DOWN -4.85110837993067 2.96174983928256e-06 MAPK signaling pathway: NLK hsa04064__135 1.25233801352621e-06 DOWN -4.84795933197226 3.0052913504671e-06 NF-kappa B signaling pathway: CCL19 hsa04151__4 1.26231171389853e-06 UP 4.84638480799305 3.02536187552977e-06 PI3K-Akt signaling pathway: RPS6 hsa04068__39 1.30297598846722e-06 UP 4.84008671207623 3.1188431622037e-06 FoxO signaling pathway: CCNB3 hsa04972__23 1.42140423882416e-06 DOWN -4.82276694830497 3.39798799586591e-06 Pancreatic secretion: KCNMA1 hsa05161__32 1.47859523546193e-06 UP 4.81489432840895 3.53021657869501e-06 Hepatitis B: STAT3 hsa04727__47 1.62502250307776e-06 UP 4.79600004065849 3.87489502954709e-06 GABAergic synapse: CACNA1A* hsa05200__220 1.66375173230533e-06 DOWN -4.79127646872087 3.9622173700909e-06 Pathways in cancer: CSF1R* hsa04024__43 1.70336732400136e-06 DOWN -4.78655289678326 4.05142683771969e-06 cAMP signaling pathway: MAPK8 hsa04933__58 1.78533552219005e-06 DOWN -4.77710575290803 4.24101826320493e-06 AGE-RAGE signaling pathway in diabetic complications: CCL2 hsa04728__61 1.90054018903556e-06 UP 4.76450956107439 4.50898360504774e-06 Dopaminergic synapse: KCNJ3 hsa04930__9 1.915426527144e-06 UP 4.76293503709518 4.53857054792379e-06 Type II diabetes mellitus: C00238 hsa04520__4 2.08683567275383e-06 UP 4.74561527332393 4.93228204918799e-06 Adherens junction: CTNND1 hsa04962__22 2.08683567275383e-06 UP 4.74561527332393 4.93228204918799e-06 Vasopressin-regulated water reabsorption: ARHGDIA hsa04012__35 2.2906035551116e-06 DOWN -4.72672098557347 5.40709055283253e-06 ErbB signaling pathway: CBLC hsa04917__38 2.32637118397172e-06 UP 4.72357193761506 5.48463168718051e-06 Prolactin signaling pathway: IRF1 hsa05205__146 2.39952186888234e-06 UP 4.71727384169824 5.65000199452369e-06 Proteoglycans in cancer: PTK2 hsa04360__145 2.673338182511e-06 UP 4.69523050598937 6.28686163321424e-06 Axon guidance: ABLIM3 hsa04724__65 3.04615935492248e-06 DOWN -4.66846359834288 7.15466678487417e-06 Glutamatergic synapse: GRM3 hsa05200__225 3.09327283713647e-06 UP 4.66531455038447 7.24720655982473e-06 Pathways in cancer: PPARD hsa05221__11 3.09327283713647e-06 UP 4.66531455038447 7.24720655982473e-06 Acute myeloid leukemia: PPARD hsa04623__9 3.14098869087898e-06 UP 4.66216550242606 7.34069371910647e-06 Cytosolic DNA-sensing pathway: IKBKE hsa05168__10 3.14098869087898e-06 DOWN -4.66216550242606 7.34069371910647e-06 Herpes simplex infection: FOS hsa04115__34 3.28840966039871e-06 DOWN -4.65271835855083 7.67567919489339e-06 p53 signaling pathway: ZMAT3 hsa04062__22 41 3.39035261158602e-06 DOWN -4.64642026263401 7.90381210567015e-06 Chemokine signaling pathway: CRK PTK2B hsa04014__27 3.44245382860796e-06 UP 4.6432712146756 8.01532929858037e-06 Ras signaling pathway: ABL1 hsa04924__23 3.52204766924179e-06 DOWN -4.63854764273799 8.19050441894223e-06 Renin secretion: ITPR1 hsa04340__49 3.54896887952246e-06 DOWN -4.63697311875878 8.2429079414372e-06 Hedgehog signaling pathway: CCND1 hsa04713__60 3.60340439157376e-06 DOWN -4.63382407080037 8.35900845897173e-06 Circadian entrainment: PER1 hsa04010__68 3.68656118531163e-06 UP 4.62910049886276 8.54136679062953e-06 MAPK signaling pathway: ATF2 hsa04022__46 3.71468666683137e-06 DOWN -4.62752597488355 8.59593133864056e-06 cGMP-PKG signaling pathway: VASP hsa04910__14 3.77155598179562e-06 DOWN -4.62437692692514 8.71679420638866e-06 Insulin signaling pathway: C00369 hsa04151__28 3.88780846914071e-06 DOWN -4.61807883100832 8.97443748589114e-06 PI3K-Akt signaling pathway: BCL2L11 hsa05145__13 3.94721509976481e-06 DOWN -4.61492978304991 9.10038916866022e-06 Toxoplasmosis: GNAI1 hsa05140__26 3.97724371951175e-06 UP 4.61335525907071 9.15838351588552e-06 Leishmaniasis: C00533 hsa04921__23 4.28982239929614e-06 DOWN -4.59761001927866 9.86606644832e-06 Oxytocin signaling pathway: C00219 hsa04917__57 4.6608211837514e-06 DOWN -4.5802902555074 1.0706213941649e-05 Prolactin signaling pathway: ESR1 hsa04742__4 4.69603207283395e-06 UP 4.5787157315282 1.07607856888475e-05 Taste transduction: TRPM5 hsa04976__36 4.69603207283395e-06 DOWN -4.5787157315282 1.07607856888475e-05 Bile secretion: SLC10A1 hsa04933__59 4.83944041725285e-06 DOWN -4.57241763561138 1.10758934762705e-05 AGE-RAGE signaling pathway in diabetic complications: SERPINE1 hsa04540__21 4.91270830057463e-06 DOWN -4.56926858765297 1.12299013342819e-05 Gap junction: C03758 hsa05205__352 4.98685064491696e-06 UP 4.56611953969456 1.13855314238141e-05 Proteoglycans in cancer: ITGA5* hsa05205__324 5.53832544962667e-06 DOWN -4.54407620398569 1.26292639803987e-05 Proteoglycans in cancer: KDR* hsa05012__71 5.83539504134307e-06 DOWN -4.53305453613125 1.32905542820408e-05 Parkinson's disease: PRKACA* hsa04071__65 5.96732626665222e-06 UP 4.52833096419364 1.35745836017428e-05 Sphingolipid signaling pathway: BAX* hsa04360__122 6.19357804674802e-06 DOWN -4.52045834429761 1.40722287180647e-05 Axon guidance: CFL1** hsa04066__26 6.23980295127065e-06 DOWN -4.51888382031841 1.4160132542799e-05 HIF-1 signaling pathway: C01245 hsa05200__224 6.62167248512122e-06 DOWN -4.50628762848477 1.49905091560756e-05 Pathways in cancer: MYC*** hsa05221__12 6.62167248512122e-06 DOWN -4.50628762848477 1.49905091560756e-05 Acute myeloid leukemia: MYC hsa04666__41 6.67094932110973e-06 UP 4.50471310450556 1.50838914252289e-05 Fc gamma R-mediated phagocytosis: MARCKS hsa05213__11 7.39874763771289e-06 DOWN -4.48266976879669 1.67094312635367e-05 Endometrial cancer: FOXO3 hsa04010__129 7.62025844053497e-06 DOWN -4.47637167287987 1.71890343454564e-05 MAPK signaling pathway: FOS hsa05200__194 7.67661898794278e-06 DOWN -4.47479714890067 1.72954041706768e-05 Pathways in cancer: BCL2 hsa04064__51 7.73337796523826e-06 DOWN -4.47322262492146 1.74024158044104e-05 NF-kappa B signaling pathway: TNFAIP3 hsa05160__7 7.79053804733647e-06 UP 4.47164810094226 1.75100729556761e-05 Hepatitis C: IRF3 hsa04014__24 7.84810192605989e-06 DOWN -4.47007357696305 1.76183793537235e-05 Ras signaling pathway: PLD1 hsa04670__54 7.90607231023767e-06 DOWN -4.46849905298385 1.77062096197099e-05 Leukocyte transendothelial migration: RAC1* hsa04932__56 7.90607231023767e-06 DOWN -4.46849905298385 1.77062096197099e-05 Non-alcoholic fatty liver disease (NAFLD): CASP7 hsa04014__68 8.08244984098999e-06 UP 4.46377548104623 1.80796705371669e-05 Ras signaling pathway: RALGDS* hsa05164__23 8.32347831165444e-06 UP 4.45747738512941 1.8596689355052e-05 Influenza A: IRF3 hsa04064__96 8.63443401440952e-06 DOWN -4.44960476523338 1.92685291129163e-05 NF-kappa B signaling pathway: BCL2A1 hsa04310__33 8.89116109113507e-06 DOWN -4.44330666931657 1.98179023609049e-05 Wnt signaling pathway: CCND1 hsa04664__3 4 5 9.02216044237848e-06 DOWN -4.44015762135816 2.00151083981458e-05 Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A hsa04014__44 9.02224417947286e-06 DOWN -4.44015762135816 2.00151083981458e-05 Ras signaling pathway: ETS1 hsa04911__56 9.02224417947286e-06 DOWN -4.44015762135816 2.00151083981458e-05 Insulin secretion: CAMK2A* hsa05200__211 9.02224417947286e-06 DOWN -4.44015762135816 2.00151083981458e-05 Pathways in cancer: CXCL8 hsa04911__4 9.4957298463063e-06 UP 4.42913595350372 2.10406561099169e-05 Insulin secretion: CACNA1C hsa04670__14 9.56527832273812e-06 UP 4.42756142952452 2.11697973715252e-05 Leukocyte transendothelial migration: SIPA1 hsa05321__81 9.63531324959303e-06 DOWN -4.42598690554531 2.12997101129239e-05 Inflammatory bowel disease (IBD): IL13 hsa04670__35 9.84836910939766e-06 UP 4.42126333360769 2.17451064119368e-05 Leukocyte transendothelial migration: PTK2 hsa04724__52 9.92038231576603e-06 UP 4.41968880962849 2.18784018442774e-05 Glutamatergic synapse: CACNA1A hsa05166__74 9.99289831299762e-06 UP 4.41811428564928 2.20124922979162e-05 HTLV-I infection: NFKB1 hsa05212__54 1.00659204305096e-05 DOWN -4.41653976167008 2.21473823055359e-05 Pancreatic cancer: C00416 hsa04740__21 1.0903540856218e-05 DOWN -4.39921999789882 2.39622845249515e-05 Olfactory transduction: PDE1A hsa05152__94 1.13059051886343e-05 DOWN -4.3913473780028 2.48175185157055e-05 Tuberculosis: CAMP hsa05152__82 1.1388061299531e-05 DOWN -4.38977285402359 2.4968689827093e-05 Tuberculosis: IL6 hsa04014__67 1.16379628985926e-05 UP 4.38504928208598 2.54868674667314e-05 Ras signaling pathway: RAPGEF5* hsa04024__44 67 1.18074627509925e-05 DOWN -4.38190023412757 2.58279656683526e-05 cAMP signaling pathway: CREB3 CREBBP hsa04510__44 1.19793172837999e-05 DOWN -4.37875118616916 2.61734153212327e-05 Focal adhesion: BCL2 hsa03320__61 1.2330196186274e-05 DOWN -4.37245309025234 2.69087556724841e-05 PPAR signaling pathway: APOA1 hsa04725__54 1.25093207133384e-05 UP 4.36930404229393 2.72679972394002e-05 Cholinergic synapse: CHRM1* hsa03320__63 1.25998020397312e-05 DOWN -4.36772951831472 2.74016528155729e-05 PPAR signaling pathway: DBI hsa04151__99 1.25998020397312e-05 UP 4.36772951831472 2.74016528155729e-05 PI3K-Akt signaling pathway: MYB hsa04916__7 1.2690907646273e-05 UP 4.36615499433552 2.75678791530022e-05 Melanogenesis: TYRP1 hsa04923__38 1.40342664063921e-05 DOWN -4.34411165862665 3.04507928147931e-05 Regulation of lipolysis in adipocytes: PDE3B hsa04724__67 1.47557858095518e-05 DOWN -4.33308999077221 3.19793789344265e-05 Glutamatergic synapse: PLD1 hsa04210__52 1.48617033543047e-05 UP 4.33151546679301 3.21347993127025e-05 Apoptosis: PARP2 hsa04962__10 1.48617033543047e-05 UP 4.33151546679301 3.21347993127025e-05 Vasopressin-regulated water reabsorption: AQP2 hsa04976__34 1.51838229992701e-05 DOWN -4.32679189485539 3.27935671444006e-05 Bile secretion: SLCO1B1 hsa04062__8 41 1.54022558848251e-05 DOWN -4.32364284689698 3.32271398479751e-05 Chemokine signaling pathway: PXN PTK2B hsa04012__23 1.71386561417506e-05 DOWN -4.30002498720891 3.69306592779236e-05 ErbB signaling pathway: RPS6KB1 hsa04062__33 1.83982315267287e-05 DOWN -4.28427974741686 3.95994009607367e-05 Chemokine signaling pathway: WAS hsa04611__7 1.91957973112028e-05 DOWN -4.27483260354163 4.12687679036043e-05 Platelet activation: ITPR1 hsa05134__7 1.93318859830559e-05 DOWN -4.27325807956242 4.15138442996137e-05 Legionellosis: IL18 hsa05205__270 2.00262255686938e-05 DOWN -4.2653854596664 4.29557966250864e-05 Proteoglycans in cancer: MAPK1**** hsa05200__216 2.01679142298598e-05 DOWN -4.26381093568719 4.32103886407145e-05 Pathways in cancer: IL6 hsa05032__25 2.05987300085965e-05 DOWN -4.25908736374958 4.4083159095846e-05 Morphine addiction: C00575* hsa04670__28 41 49 2.17908233112484e-05 UP 4.24649117191594 4.65812935174469e-05 Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1 hsa03320__46 2.32103404274239e-05 DOWN -4.23232045610309 4.95031682283306e-05 PPAR signaling pathway: APOA2 hsa04066__5 2.32103731820965e-05 DOWN -4.23232045610309 4.95031682283306e-05 HIF-1 signaling pathway: VEGFA hsa04660__26 2.35375664996211e-05 UP 4.22917140814468 5.01440900825261e-05 T cell receptor signaling pathway: GRB2 hsa04530__22 33 2.40365972232638e-05 UP 4.22444783620707 5.11492255747597e-05 Tight junction: MYL12B CGN hsa05152__68 2.42051660998994e-05 UP 4.22287331222786 5.14496686670939e-05 Tuberculosis: CD74 hsa04211__39 2.47176471198052e-05 UP 4.21814974029025 5.24796146193379e-05 Longevity regulating pathway - mammal: TP53* hsa04917__40 2.66864630326696e-05 DOWN -4.20082997651899 5.65957833390364e-05 Prolactin signaling pathway: TH hsa04380__48 2.6872659191779e-05 DOWN -4.19925545253979 5.6926411072551e-05 Osteoclast differentiation: NFATC1 hsa04024__107 64 2.80160418425277e-05 DOWN -4.18980830866456 5.92150085738016e-05 cAMP signaling pathway: NFKBIA NFKB1 hsa05164__35 2.80160418425277e-05 DOWN -4.18980830866456 5.92150085738016e-05 Influenza A: IL18 hsa05200__5 2.90040447397668e-05 UP 4.18193568876853 6.11656566397551e-05 Pathways in cancer: CASP3* hsa05210__7 2.90040447397668e-05 UP 4.18193568876853 6.11656566397551e-05 Colorectal cancer: CASP3* hsa05152__77 3.00251103250876e-05 UP 4.17406306887251 6.32479622206723e-05 Tuberculosis: IL12A hsa04151__97 3.02333820429207e-05 DOWN -4.1724885448933 6.36153693825846e-05 PI3K-Akt signaling pathway: MCL1 hsa04151__101 3.06540515709643e-05 UP 4.16933949693489 6.44283701362886e-05 PI3K-Akt signaling pathway: PKN3 hsa05166__132 136 3.28421723054785e-05 UP 4.15359425714284 6.89502142592113e-05 HTLV-I infection: CREBBP TP53 hsa04010__117 3.30689658122445e-05 DOWN -4.15201973316364 6.93488691531333e-05 MAPK signaling pathway: JUND hsa04970__21 3.35270236866408e-05 DOWN -4.14887068520523 7.02310786033424e-05 Salivary secretion: ITPR1 hsa04014__65 3.42254261886018e-05 UP 4.14414711326761 7.16142269581099e-05 Ras signaling pathway: MLLT4* hsa04151__5 3.46986806433373e-05 UP 4.1409980653092 7.25237162723369e-05 PI3K-Akt signaling pathway: EIF4B hsa04920__5 3.71596581566259e-05 DOWN -4.12525282551715 7.75811085292223e-05 Adipocytokine signaling pathway: NFKBIA hsa04310__31 3.76713439364263e-05 DOWN -4.12210377755874 7.85621035033795e-05 Wnt signaling pathway: MMP7 hsa04810__23 3.84514308146323e-05 UP 4.11738020562113 8.01000426836964e-05 Regulation of actin cytoskeleton: GSN hsa04931__135 3.87148497403913e-05 DOWN -4.11580568164192 8.04703569272071e-05 Insulin resistance: SREBF1** hsa04933__26 3.87148497403913e-05 DOWN -4.11580568164192 8.04703569272071e-05 AGE-RAGE signaling pathway in diabetic complications: IL6 hsa05161__10 3.89799809495489e-05 UP 4.11423115766272 8.09319162477374e-05 Hepatitis B: CASP3 hsa04261__3 4.060731658033e-05 DOWN -4.10478401378749 8.42176024883445e-05 Adrenergic signaling in cardiomyocytes: RYR2 hsa04064__94 4.28775796492466e-05 DOWN -4.09218782195385 8.8827973716576e-05 NF-kappa B signaling pathway: BCL2L1* hsa03320__40 4.37595690619055e-05 UP 4.08746425001623 9.05553196776657e-05 PPAR signaling pathway: FABP4 hsa04360__18 4.61964428012614e-05 UP 4.07486805818259 9.54929769236196e-05 Axon guidance: PTK2 hsa05020__46 4.68254685224674e-05 DOWN -4.07171901022418 9.66868740150727e-05 Prion diseases: PRKACA hsa04910__24 4.94237173843598e-05 DOWN -4.05912281839054 0.000101939807865216 Insulin signaling pathway: ACACA hsa04919__25 4.97579458249672e-05 UP 4.05754829441134 0.000102516644961747 Thyroid hormone signaling pathway: MTOR hsa04115__1 5.14614723839365e-05 DOWN -4.04967567451531 0.000105910302967598 p53 signaling pathway: SIAH1 hsa04014__58 59 5.18087457691675e-05 DOWN -4.04810115053611 0.000106508351532019 Ras signaling pathway: STK4 STK4 hsa04922__37 5.54058075592374e-05 DOWN -4.03235591074406 0.000113778702080664 Glucagon signaling pathway: PYGB hsa04340__20 22 5.65302523535351e-05 UP 4.02763233880644 0.0001159610744239 Hedgehog signaling pathway: GLI1 SUFU* hsa04370__28 5.76762899846679e-05 DOWN -4.02290876686883 0.00011818293225866 VEGF signaling pathway: SHC2 hsa04024__93 5.80631679147394e-05 DOWN -4.02133424288962 0.000118846070274287 cAMP signaling pathway: ORAI1 hsa04152__60 5.84525027231443e-05 UP 4.01975971891042 0.000119512788483991 AMPK signaling pathway: EEF2 hsa04012__3 5.92386015800656e-05 UP 4.01661067095201 0.000120857038402761 ErbB signaling pathway: ELK1 hsa04724__36 5.92386015800656e-05 UP 4.01661067095201 0.000120857038402761 Glutamatergic synapse: TRPC1 hsa04664__25 5.96353951330035e-05 DOWN -4.0150361469728 0.000121534606784071 Fc epsilon RI signaling pathway: MAPK14 hsa04920__16 6.04365448587144e-05 DOWN -4.01188709901439 0.000123033876261673 Adipocytokine signaling pathway: POMC hsa04932__97 6.08409310254731e-05 DOWN -4.01031257503518 0.000123723062117818 Non-alcoholic fatty liver disease (NAFLD): TNF* hsa04810__32 6.1657401570735e-05 UP 4.00716352707677 0.000125247846001525 Regulation of actin cytoskeleton: PXN hsa04727__26 6.41695041339192e-05 UP 3.99771638320154 0.000129789556800467 GABAergic synapse: KCNJ6 hsa05032__81 6.41695041339192e-05 UP 3.99771638320154 0.000129789556800467 Morphine addiction: KCNJ6 hsa05032__91 6.41695041339192e-05 UP 3.99771638320154 0.000129789556800467 Morphine addiction: KCNJ6** hsa05032__85 6.41695041339192e-05 UP 3.99771638320154 0.000129789556800467 Morphine addiction: KCNJ6* hsa04932__31 133 6.45972486036058e-05 DOWN -3.99614185922234 0.000130514225942124 Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA hsa05032__38 6.58977316926253e-05 UP 3.99141828728472 0.000132998751719058 Morphine addiction: CACNA1A hsa05142__64 6.63366209454441e-05 DOWN -3.98984376330552 0.000133740891369624 Chagas disease (American trypanosomiasis): CASP8 hsa04540__11 6.677827547697e-05 DOWN -3.98826923932631 0.00013434301886641 Gap junction: C00780 hsa05134__10 6.677827547697e-05 DOWN -3.98826923932631 0.00013434301886641 Legionellosis: NFKB1 hsa04350__12 6.72227116083862e-05 UP 3.98669471534711 0.000134948157171109 TGF-beta signaling pathway: ACVR2A hsa05217__3 6.72227116083862e-05 UP 3.98669471534711 0.000134948157171109 Basal cell carcinoma: GLI1 hsa04110__43 83 84 85 6.94871937568401e-05 DOWN -3.97882209545108 0.000139345183638317 Cell cycle: SMC1B SMC3 STAG1 RAD21 hsa04115__54 7.1350546163912e-05 DOWN -3.97252399953426 0.00014292929236886 p53 signaling pathway: PERP hsa05200__75 7.52199637117552e-05 UP 3.95992780770062 0.000150520033881137 Pathways in cancer: MAPK8 hsa04066__30 7.57173631253022e-05 DOWN -3.95835328372142 0.000151193331894201 HIF-1 signaling pathway: PDK1 hsa05169__103 7.57173631253022e-05 DOWN -3.95835328372142 0.000151193331894201 Epstein-Barr virus infection: NFKB1* hsa04530__5 10 7.67215074755236e-05 DOWN -3.95520423576301 0.000153035788265933 Tight junction: IGSF5 MAGI1 hsa04917__44 7.72282888815999e-05 UP 3.9536297117838 0.000153557624136007 Prolactin signaling pathway: PRLR** hsa04920__1 7.72282888815999e-05 DOWN -3.9536297117838 0.000153557624136007 Adipocytokine signaling pathway: C00195 hsa05120__52 7.72282888815999e-05 UP 3.9536297117838 0.000153557624136007 Epithelial cell signaling in Helicobacter pylori infection: LYN hsa05200__193 7.981002649652e-05 UP 3.94575709188778 0.000158523297872052 Pathways in cancer: NOS2 hsa03320__62 8.03354762186416e-05 UP 3.94418256790857 0.000159398479213123 PPAR signaling pathway: UBC hsa05014__2 8.13976067811078e-05 DOWN -3.94103351995016 0.000161335551837238 Amyotrophic lateral sclerosis (ALS): SLC1A2 hsa04024__115 8.5220218440413e-05 DOWN -3.93001185209573 0.000168556621525827 cAMP signaling pathway: F2R hsa05134__9 8.5220218440413e-05 DOWN -3.93001185209573 0.000168556621525827 Legionellosis: CASP7 hsa04010__67 8.57798976428884e-05 UP 3.92843732811652 0.000169307171923306 MAPK signaling pathway: ELK1 hsa04923__66 8.57798976428884e-05 DOWN -3.92843732811652 0.000169307171923306 Regulation of lipolysis in adipocytes: LIPE hsa05130__26 8.69096918205219e-05 UP 3.92528828015811 0.000171357094365961 Pathogenic Escherichia coli infection: CTNNB1 hsa04666__51 8.80535351160634e-05 DOWN -3.9221392321997 0.000173430390443483 Fc gamma R-mediated phagocytosis: NCF1 hsa04115__21 8.86307761208721e-05 DOWN -3.9205647082205 0.000174384532283894 p53 signaling pathway: DDB2 hsa05231__38 9.0384023679067e-05 UP 3.91584113628288 0.000177648096749965 Choline metabolism in cancer: RPS6KB1 hsa05161__45 9.52208896459034e-05 UP 3.90324494444924 0.000186764145766861 Hepatitis B: PCNA hsa05200__207 9.52208896459034e-05 DOWN -3.90324494444924 0.000186764145766861 Pathways in cancer: CDK4 hsa04064__134 9.58424031448733e-05 DOWN -3.90167042047004 0.000187787148601895 NF-kappa B signaling pathway: CCL21 hsa04930__13 9.64677457473442e-05 DOWN -3.90009589649083 0.000188815514853396 Type II diabetes mellitus: C00162 hsa03320__41 9.70969394843171e-05 DOWN -3.89852137251163 0.000189849270854352 PPAR signaling pathway: ANGPTL4 hsa03320__38 9.90078495634176e-05 DOWN -3.89379780057401 0.000193183540321559 PPAR signaling pathway: SORBS1 hsa05031__55 9.90078495634176e-05 DOWN -3.89379780057401 0.000193183540321559 Amphetamine addiction: GRIA1* hsa04742__37 0.000102268500831008 UP 3.88592518067799 0.000198726717653853 Taste transduction: P2RY4 hsa04723__40 0.000102271812651025 DOWN -3.88592518067799 0.000198726717653853 Retrograde endocannabinoid signaling: GRIA1 hsa04724__4 0.000102271812651025 DOWN -3.88592518067799 0.000198726717653853 Glutamatergic synapse: GRIA1 hsa05031__12 0.000102271812651025 DOWN -3.88592518067799 0.000198726717653853 Amphetamine addiction: GRIA1 hsa04210__31 32 33 0.000103605620100337 DOWN -3.88277613271958 0.000200902951670313 Apoptosis: TRAF2 RIPK1 TRADD hsa04933__56 0.000103605620100337 DOWN -3.88277613271958 0.000200902951670313 AGE-RAGE signaling pathway in diabetic complications: NFATC1 hsa04270__10 3 71 0.000106322639054759 DOWN -3.87647803680276 0.000205746898850558 Vascular smooth muscle contraction: ACTA2 MYL9 MYH11 hsa04510__20 69 0.000106322639054759 UP 3.87647803680276 0.000205746898850558 Focal adhesion: VASP ACTB hsa04750__39 0.000107012324093189 DOWN -3.87490351282355 0.000206868474250106 Inflammatory mediator regulation of TRP channels: C01245* hsa05231__48 0.000108404377834117 UP 3.87175446486514 0.00020934411711234 Choline metabolism in cancer: WAS hsa04933__57 0.00011195963322675 UP 3.86388184496912 0.000215987834530866 AGE-RAGE signaling pathway in diabetic complications: FIGF hsa05200__199 0.000112683758721916 UP 3.86230732098991 0.000216939326473852 Pathways in cancer: BCL2L1** hsa05220__3 0.000112683758721916 UP 3.86230732098991 0.000216939326473852 Chronic myeloid leukemia: BCL2L1 hsa04014__45 0.000119402655679649 UP 3.84813660517707 0.000229639293778977 Ras signaling pathway: RAB5A hsa04530__4 53 0.000120172088540659 UP 3.84656208119786 0.000230882775427299 Tight junction: OCLN OCLN hsa04933__21 0.000121725000475352 UP 3.84341303323945 0.000233627452393448 AGE-RAGE signaling pathway in diabetic complications: SMAD4 hsa04012__47 0.000129777461085673 DOWN -3.8276677934474 0.000248574770010173 ErbB signaling pathway: PRKCA hsa04064__53 0.000129777461085673 DOWN -3.8276677934474 0.000248574770010173 NF-kappa B signaling pathway: CXCL8 hsa05161__207 0.000137451458250097 UP 3.81349707763456 0.000262737833216614 Hepatitis B: CDK2 hsa05161__219 0.000137451458250097 UP 3.81349707763456 0.000262737833216614 Hepatitis B: CDK2* hsa04742__34 0.000140102741322285 UP 3.80877350569694 0.000267533588358307 Taste transduction: GRM1 hsa05010__50 0.000142802798133174 DOWN -3.80404993375933 0.000272412647403284 Alzheimer's disease: ERN1 hsa04740__33 0.000144628593568727 UP 3.80090088580092 0.000275615747784624 Olfactory transduction: CNGA3* hsa05223__7 0.000146478711790261 DOWN -3.79775183784251 0.000278858662060689 Non-small cell lung cancer: FOXO3 hsa05100__24 0.000147411513345294 DOWN -3.7961773138633 0.000280350438841911 Bacterial invasion of epithelial cells: ACTB hsa04932__58 0.000148349905947661 UP 3.7946027898841 0.000281849821310065 Non-alcoholic fatty liver disease (NAFLD): BAX hsa04151__100 0.000150243589138847 UP 3.79145374192569 0.000285159296961509 PI3K-Akt signaling pathway: PRKCA hsa05010__49 0.000154099430311168 DOWN -3.78515564600887 0.000292182471800892 Alzheimer's disease: EIF2AK3 hsa05321__74 0.000156062098569272 DOWN -3.78200659805046 0.00029560552743111 Inflammatory bowel disease (IBD): IL5 hsa05014__54 0.000158048276461631 DOWN -3.77885755009205 0.000299066174694264 Amyotrophic lateral sclerosis (ALS): PPP3CA hsa04380__72 0.000164150498017517 DOWN -3.76941040621682 0.000310300589310779 Osteoclast differentiation: MAPK1 hsa04520__44 52 45 0.000166233357903692 UP 3.76626135825841 0.00031392208995079 Adherens junction: ACTB ACTN4 CTNNA1 hsa04062__59 0.000167284087522725 DOWN -3.7646868342792 0.000314956713882966 Chemokine signaling pathway: FOXO3 hsa04930__7 0.000167284087522725 UP 3.7646868342792 0.000314956713882966 Type II diabetes mellitus: C00002 hsa04950__8 0.000167284087522725 UP 3.7646868342792 0.000314956713882966 Maturity onset diabetes of the young: NEUROD1 hsa04152__38 0.000171549806521236 UP 3.75838873836238 0.000322664751204607 AMPK signaling pathway: PFKL hsa04115__64 0.000178140633027529 DOWN -3.74894159448715 0.000334726249458727 p53 signaling pathway: PMAIP1 hsa05142__84 0.000182666008337123 DOWN -3.74264349857033 0.000342886543122332 Chagas disease (American trypanosomiasis): NFKB1* hsa04550__25 0.000187299297446321 UP 3.73634540265351 0.000351232914073491 Signaling pathways regulating pluripotency of stem cells: MAPK1 hsa05205__121 0.000198131189959856 DOWN -3.72217468684067 0.000371174980991594 Proteoglycans in cancer: PLAUR hsa05014__32 34 0.000201870739960731 DOWN -3.71745111490305 0.000377803904767145 Amyotrophic lateral sclerosis (ALS): NEFM PRPH hsa05220__21 0.000203131921260212 DOWN -3.71587659092385 0.000379408429471113 Chronic myeloid leukemia: NFKBIA hsa05321__123 0.000203131921260212 UP 3.71587659092385 0.000379408429471113 Inflammatory bowel disease (IBD): IL5* hsa05161__188 0.000205676520783791 UP 3.71272754296544 0.000383779724481373 Hepatitis B: IFNB1 hsa04015__3 0.000216157379615038 UP 3.7001313511318 0.000402936226484779 Rap1 signaling pathway: MAPK1 hsa04340__50 0.000220215426958091 DOWN -3.69540777919418 0.000410093941778249 Hedgehog signaling pathway: BCL2 hsa05164__19 0.000224344916002588 DOWN -3.69068420725657 0.000417370393236497 Influenza A: NFKB1 hsa04668__120 0.000228547010717209 UP 3.68596063531895 0.000424767391827534 TNF signaling pathway: DNM1L hsa04340__40 0.000231389326254223 UP 3.68281158736054 0.00042962504350957 Hedgehog signaling pathway: SUFU hsa04071__59 60 0.000232822892267402 DOWN -3.68123706338134 0.000431860034126799 Sphingolipid signaling pathway: TP53 BCL2 hsa04152__68 0.000234264789848719 DOWN -3.67966253940213 0.000434106055350832 AMPK signaling pathway: PPARGC1A** hsa04064__54 0.000235715063823988 UP 3.67808801542293 0.000435933666265034 NF-kappa B signaling pathway: CCL13 hsa04520__69 0.000235715063823988 DOWN -3.67808801542293 0.000435933666265034 Adherens junction: IQGAP1** hsa04015__30 0.000238640921354338 DOWN -3.67493896746452 0.000440910807497345 Rap1 signaling pathway: ITGAL hsa04530__4 45 0.000255351675335923 UP 3.65761920369326 0.000471322001921611 Tight junction: OCLN TJP2 hsa04115__36 0.000256924049753729 DOWN -3.65604467971406 0.000473758870939407 p53 signaling pathway: EI24 hsa04720__4 15 0.000258505499732329 DOWN -3.65447015573485 0.000476207680389262 Long-term potentiation: CREBBP ATF4 hsa04724__68 0.00027148968194032 UP 3.64187396390121 0.000499636740808874 Glutamatergic synapse: MAPK1 hsa04062__43 0.000274829928789896 DOWN -3.6387249159428 0.000505289076512929 Chemokine signaling pathway: STAT1 hsa04022__50 0.000278208661637319 DOWN -3.63557586798439 0.000511001051042544 cGMP-PKG signaling pathway: ATP2B1 hsa05162__93 0.000279912588138265 UP 3.63400134400519 0.000513628665148242 Measles: TP53 hsa04380__20 0.000283349819101112 DOWN -3.63085229604678 0.000519428595210721 Osteoclast differentiation: MAP2K1 hsa04970__39 0.000286825359173102 UP 3.62770324808837 0.000524778110977821 Salivary secretion: KCNN4 hsa04976__41 0.000286826567309325 UP 3.62770324808837 0.000524778110977821 Bile secretion: CYP7A1 hsa05014__49 0.000306671440473478 DOWN -3.61038348431711 0.000560540502577494 Amyotrophic lateral sclerosis (ALS): C00001 hsa04916__8 0.000312306032348948 UP 3.60565991237949 0.00057028477627179 Melanogenesis: TYR* hsa04912__20 0.000316114360760358 UP 3.60251086442109 0.000576678528027876 GnRH signaling pathway: PLA2G4B hsa04610__7 0.000321908445808173 DOWN -3.59778729248347 0.000586110435730192 Complement and coagulation cascades: C00290 hsa04662__10 0.000321908445808173 UP 3.59778729248347 0.000586110435730192 B cell receptor signaling pathway: GSK3B hsa04727__13 0.000329788608343439 UP 3.59148919656665 0.000599876858738937 GABAergic synapse: CACNA1A hsa04015__67 0.00033178666386262 DOWN -3.58991467258744 0.000602345064152525 Rap1 signaling pathway: AKT3 hsa05212__29 0.00033178666386262 DOWN -3.58991467258744 0.000602345064152525 Pancreatic cancer: VEGFA hsa04071__1 0.000337849007193398 UP 3.58519110064983 0.000612758961888412 Sphingolipid signaling pathway: MAPK1 hsa05142__36 0.000341947978493254 UP 3.58204205269142 0.000619595228147372 Chagas disease (American trypanosomiasis): SMAD2 hsa04621__21 30 0.000350285870542505 DOWN -3.5757439567746 0.0006340916673886 NOD-like receptor signaling pathway: NLRP3 PYCARD hsa04071__69 0.000352399855066354 UP 3.57416943279539 0.000637304453965043 Sphingolipid signaling pathway: RAC1 hsa04210__59 0.000360975690516666 DOWN -3.56787133687857 0.000652185887000784 Apoptosis: PMAIP1 hsa04390__95 0.000371969958409555 UP 3.55999871698255 0.000671403988330023 Hippo signaling pathway: AFP hsa04390__78 0.000380989924767855 UP 3.55370062106573 0.000687025017887524 Hippo signaling pathway: SOX2 hsa04213__55 0.000385576185951333 UP 3.55055157310732 0.000694628622629488 Longevity regulating pathway - multiple species: CRYAB hsa04022__43 0.00038788861629349 DOWN -3.54897704912811 0.000697457138770783 cGMP-PKG signaling pathway: MAPK1 hsa05219__27 0.00038788861629349 DOWN -3.54897704912811 0.000697457138770783 Bladder cancer: RPS6KA5 hsa04066__59 0.000390214001664761 UP 3.54740252514891 0.000700967599548839 HIF-1 signaling pathway: NOS2 hsa05215__14 0.000394903904929114 DOWN -3.5442534771905 0.00070871483988711 Prostate cancer: CCND1 hsa05205__195 0.000397268557313707 DOWN -3.54267895321129 0.000712278262588221 Proteoglycans in cancer: CDKN1A hsa04520__7 68 0.000402037602152297 DOWN -3.53952990525288 0.000719455861375395 Adherens junction: CDH1 CTNNB1 hsa05220__15 0.000402037602152297 DOWN -3.53952990525288 0.000719455861375395 Chronic myeloid leukemia: MYC hsa04014__100 0.000411736567845561 DOWN -3.53323180933606 0.000736111332998867 Ras signaling pathway: REL hsa04022__57 0.000414195227909236 DOWN -3.53165728535686 0.000739803073423437 cGMP-PKG signaling pathway: C00144 hsa05166__53 146 0.000416667594807859 UP 3.53008276137765 0.000743512260820481 HTLV-I infection: CREB1 CRTC2 hsa04390__74 0.000429237501942521 UP 3.52221014148163 0.000764490299668244 Hippo signaling pathway: AXIN1 hsa05160__77 0.000429237501942521 DOWN -3.52221014148163 0.000764490299668244 Hepatitis C: NFKB1* hsa04726__16 0.000442160755827924 DOWN -3.5143375215856 0.000786017086282563 Serotonergic synapse: ITPR1 hsa04726__46 0.000442160755827924 DOWN -3.5143375215856 0.000786017086282563 Serotonergic synapse: ITPR1* hsa05212__27 0.000447431027950262 DOWN -3.51118847362719 0.000794634122418282 Pancreatic cancer: BCL2L1* hsa04024__113 0.000463595738622375 DOWN -3.50174132975196 0.000822565054647255 cAMP signaling pathway: PTCH1 hsa04024__108 0.00046634225749584 UP 3.50016680577276 0.000825878512568034 cAMP signaling pathway: AMH hsa04919__31 0.00046634225749584 UP 3.50016680577276 0.000825878512568034 Thyroid hormone signaling pathway: ATP2A2 hsa05216__11 0.000469103951059217 DOWN -3.49859228179355 0.000829987122448465 Thyroid cancer: MYC hsa04370__36 0.000483142744959115 DOWN -3.49071966189753 0.000854021841748051 VEGF signaling pathway: NOS3 hsa04012__43 0.000500506370812608 UP 3.4812725180223 0.000883882961237678 ErbB signaling pathway: PTK2 hsa04932__7 0.000509404740569066 DOWN -3.47654894608468 0.000898752589229366 Non-alcoholic fatty liver disease (NAFLD): SREBF1 hsa04115__49 0.000536992607362929 DOWN -3.46237823027184 0.000945650524118972 p53 signaling pathway: MDM2* hsa04151__96 0.000536992607362929 DOWN -3.46237823027184 0.000945650524118972 PI3K-Akt signaling pathway: BCL2 hsa03320__59 0.000549695365371276 DOWN -3.45608013435502 0.000964404847369401 PPAR signaling pathway: NR1H3 hsa04610__23 0.000549695365371276 DOWN -3.45608013435502 0.000964404847369401 Complement and coagulation cascades: BDKRB1 hsa05031__10 0.000549695365371276 DOWN -3.45608013435502 0.000964404847369401 Amphetamine addiction: CACNA1C hsa05031__53 0.000549695365371276 DOWN -3.45608013435502 0.000964404847369401 Amphetamine addiction: CACNA1C* hsa04750__60 0.000556143722826793 DOWN -3.45293108639661 0.000974807887305545 Inflammatory mediator regulation of TRP channels: TRPV3 hsa05213__31 0.000565967464776484 DOWN -3.44820751445899 0.000991102391719491 Endometrial cancer: MYC hsa05215__35 0.000582687237882615 UP 3.44033489456297 0.00101943139663076 Prostate cancer: CASP9 hsa04062__25 0.000586085899093437 DOWN -3.43876037058376 0.00102442363199681 Chemokine signaling pathway: ROCK1 hsa05217__5 0.00062110236938324 UP 3.42301513079171 0.00108462021567947 Basal cell carcinoma: BMP2 hsa04152__57 0.000628335224572338 UP 3.4198660828333 0.00109623202132908 AMPK signaling pathway: ACACA* hsa04022__49 0.000639331553477712 DOWN -3.41514251089569 0.00111438217902098 cGMP-PKG signaling pathway: ATP1B4 hsa05162__44 0.000643036596302102 DOWN -3.41356798691648 0.00111980144990885 Measles: PRKCQ hsa04724__26 0.000650506668171493 UP 3.41041893895807 0.00113176113842059 Glutamatergic synapse: PRKACA hsa05162__105 0.000658057378974828 UP 3.40726989099966 0.00114383886687669 Measles: GSK3B hsa05145__29 0.000661857652038222 DOWN -3.40569536702046 0.00114938126449151 Toxoplasmosis: C06314 hsa04024__12 0.000665689523519594 DOWN -3.40412084304125 0.00115496824994766 cAMP signaling pathway: SLC9A1 hsa05145__11 0.000669536383720846 DOWN -3.40254631906205 0.00116057090868217 Toxoplasmosis: MAPK14 hsa05168__92 93 0.000673403903561425 DOWN -3.40097179508284 0.0011661990182414 Herpes simplex infection: IRF9 STAT1 hsa04920__12 0.000681199425195747 DOWN -3.39782274712443 0.00117861300178896 Adipocytokine signaling pathway: C00165 hsa04115__56 0.000685131436258496 DOWN -3.39624822314523 0.00118432563820581 p53 signaling pathway: SESN3 hsa04730__8 0.000750949529038613 UP 3.37105583947795 0.00129690640171282 Long-term depression: GNA13* hsa04660__14 0.00076392603830471 DOWN -3.36633226754033 0.00131810562532098 T cell receptor signaling pathway: NFKB1 hsa05215__30 0.000768297601462978 UP 3.36475774356113 0.0013244322872926 Prostate cancer: TP53 hsa04210__99 0.000786017140648078 DOWN -3.35845964764431 0.00135249652681112 Apoptosis: BID** hsa04933__65 0.000786017140648078 UP 3.35845964764431 0.00135249652681112 AGE-RAGE signaling pathway in diabetic complications: COL1A1 hsa04390__17 51 0.00079501846674151 UP 3.3553105996859 0.00136673348491061 Hippo signaling pathway: YWHAQ YAP1 hsa04921__58 0.000804115382753805 UP 3.35216155172749 0.00138110859615576 Oxytocin signaling pathway: MEF2C hsa04064__142 0.000817942011171483 DOWN -3.34743797978987 0.00140101462077595 NF-kappa B signaling pathway: NFKB2* hsa05016__48 0.000817942011171483 UP 3.34743797978987 0.00140101462077595 Huntington's disease: HIP1 hsa05016__46 0.000817942011171483 UP 3.34743797978987 0.00140101462077595 Huntington's disease: HTT** hsa04066__63 0.000846259389051192 DOWN -3.33799083591464 0.0014455649018429 HIF-1 signaling pathway: TIMP1* hsa04066__57 0.000846259389051192 DOWN -3.33799083591464 0.0014455649018429 HIF-1 signaling pathway: TIMP1 hsa04510__47 0.000846259389051192 DOWN -3.33799083591464 0.0014455649018429 Focal adhesion: CCND1 hsa05200__195 0.000860756563142335 DOWN -3.33326726397703 0.00146899326261984 Pathways in cancer: BIRC8 hsa05169__79 0.0008656399045681 DOWN -3.33169273999782 0.00147598673383254 Epstein-Barr virus infection: ATF2 hsa04115__19 0.000870548924392326 UP 3.33011821601862 0.0014803270850074 p53 signaling pathway: RFWD2 hsa04723__42 0.000870548924392326 UP 3.33011821601862 0.0014803270850074 Retrograde endocannabinoid signaling: KCNJ3 hsa04723__50 0.000870548924392326 UP 3.33011821601862 0.0014803270850074 Retrograde endocannabinoid signaling: KCNJ3* hsa04961__17 0.000900549202377218 DOWN -3.32067107214339 0.00152995655629909 Endocrine and other factor-regulated calcium reabsorption: CALB1 hsa04726__10 0.000942041146537747 UP 3.30807488030975 0.00159900209064537 Serotonergic synapse: PRKACA hsa04152__53 0.000963444804138325 DOWN -3.30177678439293 0.00163385630593494 AMPK signaling pathway: G6PC hsa04915__21 0.000990832678579595 DOWN -3.2939041644969 0.00167878683773765 Estrogen signaling pathway: CREB3 hsa04810__30 0.0010019882889839 DOWN -3.29075511653849 0.00169615855405472 Regulation of actin cytoskeleton: VCL* hsa04151__51 0.00101326007515639 DOWN -3.28760606858008 0.00171369548264524 PI3K-Akt signaling pathway: NOS3 hsa04650__15 0.00102464913402436 DOWN -3.28445702062167 0.00173139903132353 Natural killer cell mediated cytotoxicity: TNF hsa04630__1 0.00103615657158965 DOWN -3.28130797266326 0.00174927061816437 Jak-STAT signaling pathway: MYC hsa04390__80 0.00104778350298997 UP 3.27815892470485 0.00176731167156029 Hippo signaling pathway: BIRC2 hsa04350__11 0.00107738101827033 UP 3.27028630480883 0.00181560442451117 TGF-beta signaling pathway: SMAD4* hsa03320__55 0.00109550879290687 DOWN -3.26556273287121 0.00184449912354123 PPAR signaling pathway: SCD hsa05200__213 0.00110161379469711 DOWN -3.26398820889201 0.00185311756511715 Pathways in cancer: CSF2RA hsa04520__9 57 0.00110775024462854 UP 3.2624136849128 0.0018617734433426 Adherens junction: LEF1 CTNNB1 hsa04740__37 0.00111391828940575 UP 3.2608391609336 0.00187046690419428 Olfactory transduction: CNGB1* hsa03320__32 0.0011201180763316 DOWN -3.25926463695439 0.00187919809413132 PPAR signaling pathway: FABP3 hsa05150__40 0.00114523662982687 DOWN -3.25296654103757 0.0019196250021808 Staphylococcus aureus infection: FCGR1A hsa04650__110 111 0.00115159834092034 DOWN -3.25139201705837 0.00192685065235023 Natural killer cell mediated cytotoxicity: ITGAL ITGB2 hsa05223__21 0.00115159834092034 DOWN -3.25139201705837 0.00192685065235023 Non-small cell lung cancer: FOXO3* hsa05032__37 0.00117087696443895 UP 3.24666844512075 0.00195736460514305 Morphine addiction: KCNJ3 hsa05200__219 0.00118389460214566 DOWN -3.24351939716234 0.00197736707327262 Pathways in cancer: MYC** hsa05031__97 0.00119045344779579 DOWN -3.24194487318314 0.00198655597549581 Amphetamine addiction: ARC hsa05010__47 0.00121033194946834 DOWN -3.23722130124552 0.00201793587670897 Alzheimer's disease: C00533 hsa04912__33 0.00122375414831777 UP 3.23407225328711 0.00203850535876692 GnRH signaling pathway: ELK1 hsa04310__13 0.0012441453924974 DOWN -3.2293486813495 0.00207063701727424 Wnt signaling pathway: NFATC1 hsa03320__36 0.00125101189503752 DOWN -3.22777415737029 0.00208022243431461 PPAR signaling pathway: SLC27A4 hsa04062__44 0.00127182191074639 DOWN -3.22305058543267 0.00211295611873782 Chemokine signaling pathway: MAPK1 hsa04022__51 0.00132888765712796 DOWN -3.21045439359904 0.00220581263934933 cGMP-PKG signaling pathway: GTF2I hsa04726__41 0.00133618353609475 UP 3.20887986961983 0.00221206252402529 Serotonergic synapse: HTR3C hsa04742__57 0.00133618353609475 UP 3.20887986961983 0.00221206252402529 Taste transduction: HTR3C hsa04611__25 0.00133618465394822 UP 3.20887986961983 0.00221206252402529 Platelet activation: ORAI1 hsa05162__28 34 0.00135088967234085 DOWN -3.20573082166142 0.00223247290618159 Measles: IRF9 STAT1 hsa05211__27 0.00135088967234085 UP 3.20573082166142 0.00223247290618159 Renal cell carcinoma: VEGFA* hsa04919__30 0.00139590516749729 DOWN -3.19628367778619 0.0023048381456304 Thyroid hormone signaling pathway: MYH6 hsa04664__47 0.0014112150628488 DOWN -3.19313462982778 0.00232807120552492 Fc epsilon RI signaling pathway: MAPK8 hsa04012__31 0.00142667964243632 UP 3.18998558186937 0.00234945753561599 ErbB signaling pathway: BAD hsa04014__61 0.00142667964243632 DOWN -3.18998558186937 0.00234945753561599 Ras signaling pathway: RAP1A hsa04662__24 0.00143447037837214 DOWN -3.18841105789016 0.00236021877492229 B cell receptor signaling pathway: FOS hsa04064__36 0.00147401562174641 UP 3.18053843799414 0.00242316303872397 NF-kappa B signaling pathway: PLCG1 hsa04010__66 0.00149011312918722 UP 3.17738939003573 0.00244748476376117 MAPK signaling pathway: TP53 hsa04062__53 0.0015145632894114 DOWN -3.17266581809811 0.00248547110987251 Chemokine signaling pathway: NFKB1 hsa05200__48 0.00152279511536073 DOWN -3.17109129411891 0.00249679932090996 Pathways in cancer: MTOR hsa04742__23 45 0.00153106187608117 DOWN -3.1695167701397 0.00250599044047083 Taste transduction: PKD1L3 PKD2L1 hsa05205__189 0.00153106813499761 DOWN -3.1695167701397 0.00250599044047083 Proteoglycans in cancer: IL12B hsa05133__27 0.00153938253385095 DOWN -3.1679422461605 0.00251740624987461 Pertussis: IRF3 hsa05210__40 0.00157305765733357 DOWN -3.16164415024368 0.00257023942446067 Colorectal cancer: CASP9 hsa04115__39 0.00162484371494751 UP 3.15219700636845 0.00265254677705158 p53 signaling pathway: BAX hsa04668__141 0.00171465233187918 DOWN -3.1364517665764 0.00279672893368141 TNF signaling pathway: JUN* hsa04919__102 0.00172387985042977 UP 3.13487724259719 0.00280934105720515 Thyroid hormone signaling pathway: BMP4 hsa04520__58 0.00174131870943041 DOWN -3.13172819463878 0.00283530143415922 Adherens junction: CDH1* hsa04668__38 0.00176124843121906 DOWN -3.12857914668037 0.00286526909286633 TNF signaling pathway: CEBPB hsa04915__28 0.00179936043657427 UP 3.12228105076355 0.00292473897951822 Estrogen signaling pathway: KCNJ3 hsa04520__44 47 0.0018382291146717 UP 3.11598295484673 0.00298533492348152 Adherens junction: ACTB TJP1 hsa04611__43 0.00187786791609299 DOWN -3.10968485892991 0.00304707583276228 Platelet activation: MYL12B hsa04390__76 0.00198042433319556 DOWN -3.09393961913786 0.00321071382405044 Hippo signaling pathway: MYC hsa04014__37 0.00200154265265855 DOWN -3.09079057117945 0.00324215400374604 Ras signaling pathway: FASLG hsa04310__20 0.00203360787579897 UP 3.08606699924184 0.00328842443943741 Wnt signaling pathway: MAPK8 hsa05160__70 0.00203360787579897 DOWN -3.08606699924184 0.00328842443943741 Hepatitis C: CDKN1A hsa04115__16 0.00204440058553774 DOWN -3.08449247526263 0.00330303413604937 p53 signaling pathway: PPM1D hsa04350__10 0.00206614382363288 UP 3.08134342730422 0.00333529574278881 TGF-beta signaling pathway: SMAD4 hsa05220__22 0.00213265265743899 DOWN -3.07189628342899 0.00343970329899387 Chronic myeloid leukemia: CDKN1B hsa04912__19 0.00221272443473587 UP 3.06087461557456 0.00356578834722873 GnRH signaling pathway: MAPK7 hsa05210__22 0.00227159532624247 DOWN -3.05300199567853 0.00365752152357292 Colorectal cancer: MYC hsa05321__122 0.00229554284423527 UP 3.04985294772012 0.00369291524342301 Inflammatory bowel disease (IBD): IL4** hsa04062__42 0.00239366328896116 DOWN -3.03725675588648 0.00384747076129856 Chemokine signaling pathway: PAK1 hsa04950__21 0.00240619465092917 DOWN -3.03568223190728 0.00386430747785975 Maturity onset diabetes of the young: PKLR hsa04920__2 0.00243143770477735 DOWN -3.03253318394887 0.00390151276454026 Adipocytokine signaling pathway: C00638 hsa04152__56 0.00246975696648998 UP 3.02780961201125 0.00395961889081457 AMPK signaling pathway: FASN hsa05219__12 0.00248265233679923 UP 3.02623508803205 0.00397690003482161 Bladder cancer: ERBB2 hsa04360__114 0.00258805412077548 UP 3.01363889619841 0.00414220927848136 Axon guidance: RAF1 hsa04725__50 0.002642275201067 DOWN -3.00734080028159 0.00422539157685523 Cholinergic synapse: BCL2 hsa05152__15 0.00265599173955375 DOWN -3.00576627630238 0.00424371469270535 Tuberculosis: CTSD hsa04662__27 0.00269753276683886 DOWN -3.00104270436477 0.0043027708564433 B cell receptor signaling pathway: NFATC1 hsa04810__31 0.00269753276683886 DOWN -3.00104270436477 0.0043027708564433 Regulation of actin cytoskeleton: MSN hsa04024__101 0.00273966670062629 UP 2.99631913242715 0.00436627118785139 cAMP signaling pathway: HCN4 hsa04115__58 0.00282574340344289 UP 2.98687198855192 0.00449582714231092 p53 signaling pathway: CASP3 hsa04728__60 0.00282574340344289 UP 2.98687198855192 0.00449582714231092 Dopaminergic synapse: CACNA1A hsa05161__44 0.00285497987016962 UP 2.98372294059351 0.00453850014894138 Hepatitis B: CXCL8 hsa05162__13 0.00289935264805839 DOWN -2.9789993686559 0.00460514254074532 Measles: IRF7 hsa04350__27 0.00294435406351064 DOWN -2.97427579671828 0.00467267000450717 TGF-beta signaling pathway: ACVR2A* hsa05200__52 0.0029594955934934 UP 2.97270127273908 0.00469273605077983 Pathways in cancer: CDKN1B hsa04210__71 0.0029899920042648 DOWN -2.96955222478067 0.0047331044448303 Apoptosis: GADD45G hsa05211__42 0.0029899920042648 UP 2.96955222478067 0.0047331044448303 Renal cell carcinoma: SLC2A1* hsa05160__12 13 14 0.00308320942808587 DOWN -2.96010508090544 0.00487655767287319 Hepatitis C: IKBKG CHUK IKBKB hsa04917__46 0.00319530796899961 DOWN -2.949083413051 0.00504536443172291 Prolactin signaling pathway: GCK hsa04970__27 0.00319530796899961 DOWN -2.949083413051 0.00504536443172291 Salivary secretion: PRKCA hsa05200__200 0.00326101975050258 DOWN -2.94278531713418 0.00514479942165772 Pathways in cancer: FIGF hsa05010__12 0.00336189797145244 UP 2.93333817325895 0.00529950191976437 Alzheimer's disease: CASP3 hsa04210__56 0.0034481249111831 UP 2.92546555336293 0.00543086899255075 Apoptosis: BAX hsa04919__46 0.00348317574483676 UP 2.92231650540452 0.00548148008756136 Thyroid hormone signaling pathway: ATP1B4 hsa04950__7 0.00355425192199406 DOWN -2.9160184094877 0.00558865218529443 Maturity onset diabetes of the young: FOXA3 hsa05014__31 34 0.00362664513589015 DOWN -2.90972031357088 0.00569295422751679 Amyotrophic lateral sclerosis (ALS): NEFL PRPH hsa05168__39 40 0.00362664513589015 UP 2.90972031357088 0.00569295422751679 Herpes simplex infection: POU2F3 HCFC2 hsa05152__112 0.00364495173718077 DOWN -2.90814578959167 0.00571691512033611 Tuberculosis: IFNGR1 hsa04913__21 0.00377546888352303 DOWN -2.89712412173724 0.00591175502678314 Ovarian steroidogenesis: CYP17A1 hsa04913__22 0.00377546888352303 DOWN -2.89712412173724 0.00591175502678314 Ovarian steroidogenesis: CYP17A1* hsa04024__62 0.00389070578913726 UP 2.88767697786201 0.0060820600480773 cAMP signaling pathway: BAD hsa05012__57 0.00389070578913726 UP 2.88767697786201 0.0060820600480773 Parkinson's disease: CASP3 hsa04621__23 0.00406955909446534 DOWN -2.87350626204916 0.00635636038113082 NOD-like receptor signaling pathway: CASP1 hsa04024__112 0.00429827597262426 UP 2.85618649827791 0.00670802371475165 cAMP signaling pathway: GLI1 hsa04530__11 20 16 0.00438429405231173 UP 2.84988840236109 0.00683658798696576 Tight junction: TJP1 ACTB CTTN hsa04915__30 0.00447186955910486 UP 2.84359030644427 0.00696736559001496 Estrogen signaling pathway: CREB3* hsa05169__64 0.00449400966686879 UP 2.84201578246506 0.00699605978794238 Epstein-Barr virus infection: NFKB2 hsa04630__31 0.00453858807444632 UP 2.83886673450665 0.0070596084369906 Jak-STAT signaling pathway: BCL2L1 hsa04540__12 0.00462894246449765 UP 2.83256863858983 0.00719419593944672 Gap junction: C00025 hsa05110__46 0.00465179182048001 UP 2.83099411461063 0.0072177678205466 Vibrio cholerae infection: PLCG1 hsa05164__77 0.00465179182048001 UP 2.83099411461063 0.0072177678205466 Influenza A: CASP9 hsa04014__97 0.00467473704955013 DOWN -2.82941959063142 0.00724738524431081 Ras signaling pathway: PAK4 hsa04210__3 0.0046977846988076 UP 2.82784506665222 0.00727711248891961 Apoptosis: BCL2L1 hsa05142__44 0.00518087096087043 UP 2.79635458706812 0.00801882745920555 Chagas disease (American trypanosomiasis): PLCB1 hsa04530__8 0.00525708433325679 UP 2.7916310151305 0.00811673086457643 Tight junction: LLGL2 hsa04550__22 0.00525708433325679 UP 2.7916310151305 0.00811673086457643 Signaling pathways regulating pluripotency of stem cells: SMAD2 hsa05161__92 0.00525708433325679 UP 2.7916310151305 0.00811673086457643 Hepatitis B: NFKBIA hsa04670__39 0.00546529613693502 DOWN -2.77903482329686 0.0084312737613308 Leukocyte transendothelial migration: MAPK14 hsa05012__70 0.00557216863045621 DOWN -2.77273672738004 0.00858909340166302 Parkinson's disease: PRKACA hsa04713__56 0.00573601538559745 UP 2.76328958350481 0.00883440402421115 Circadian entrainment: KCNJ3 hsa05168__106 134 0.00576374171736713 UP 2.7617150595256 0.00886983676243475 Herpes simplex infection: SRSF8 C1QBP hsa04150__31 0.0057915888419142 DOWN -2.7601405355464 0.00890539724546381 mTOR signaling pathway: EIF4E hsa04917__68 0.00581955721614832 UP 2.75856601156719 0.00894108586193188 Prolactin signaling pathway: CCND1 hsa04024__109 0.00587585954825378 DOWN -2.75541696360878 0.00902021249278501 cAMP signaling pathway: BDNF hsa04917__65 0.00601876949935576 UP 2.74754434371276 0.00923205541982814 Prolactin signaling pathway: CYP17A1 hsa05205__113 0.00613534388180788 DOWN -2.74124624779594 0.00940319017448369 Proteoglycans in cancer: TP53 hsa05100__55 0.00619439023228442 UP 2.73809719983753 0.00948594885612259 Bacterial invasion of epithelial cells: ACTB* hsa04668__20 0.00637461167134365 DOWN -2.7286500559623 0.00975398642545173 TNF signaling pathway: IKBKG hsa05215__13 0.00640510314535286 DOWN -2.72707553198309 0.00978470634968945 Prostate cancer: BCL2 hsa05218__9 0.00640510314535286 DOWN -2.72707553198309 0.00978470634968945 Melanoma: CCND1 hsa04950__30 0.00643572578855447 UP 2.72550100800389 0.00982350020852465 Maturity onset diabetes of the young: PAX6* hsa04210__57 0.00649736653607464 UP 2.72235196004548 0.00990953873480865 Apoptosis: BAK1 hsa05014__13 0.00659082367387992 UP 2.71762838810786 0.0100357841841332 Amyotrophic lateral sclerosis (ALS): CASP3 hsa05161__97 0.00659082367387992 UP 2.71762838810786 0.0100357841841332 Hepatitis B: BCL2 hsa04972__18 0.00671731319267489 UP 2.71133029219104 0.0102201064688551 Pancreatic secretion: PRKCA hsa05164__70 0.00681360779524219 DOWN -2.70660672025343 0.0103498537164592 Influenza A: RNASEL hsa05168__83 0.00681360779524219 DOWN -2.70660672025343 0.0103498537164592 Herpes simplex infection: RNASEL hsa04015__11 0.00684598057629024 UP 2.70503219627422 0.0103822417294991 Rap1 signaling pathway: RAC1 hsa04728__54 0.00684598057629024 UP 2.70503219627422 0.0103822417294991 Dopaminergic synapse: CAMK2A hsa05200__210 0.00700992668104073 DOWN -2.6971595763782 0.010622300188448 Pathways in cancer: MMP1 hsa04932__35 0.00724537487367128 DOWN -2.68613790852376 0.0109702331890639 Non-alcoholic fatty liver disease (NAFLD): PRKAG2 hsa04520__34 0.007558511833537 DOWN -2.67196719271092 0.0114259402535929 Adherens junction: RHOA hsa04913__64 0.007558511833537 UP 2.67196719271092 0.0114259402535929 Ovarian steroidogenesis: PLA2G4B hsa04062__38 0.00795767959719118 DOWN -2.65464742893966 0.0120196784269471 Chemokine signaling pathway: NCF1 hsa04710__23 0.00833683226839883 DOWN -2.63890218914761 0.0125822552870051 Circadian rhythm: BHLHE41 hsa04914__23 0.00849296375400333 UP 2.63260409323079 0.0128076074588862 Progesterone-mediated oocyte maturation: PRKACA hsa05210__31 0.00857200574524252 UP 2.62945504527238 0.0129164384886213 Colorectal cancer: BCL2 hsa05169__117 0.00865170474534896 DOWN -2.62630599731397 0.0130260843081015 Epstein-Barr virus infection: CDKN1A hsa05120__19 0.00873206541857859 DOWN -2.62315694935556 0.0131365499771891 Epithelial cell signaling in Helicobacter pylori infection: CXCL1 hsa04066__47 0.00877249534717784 DOWN -2.62158242537636 0.0131868150058777 HIF-1 signaling pathway: PGK1 hsa04012__40 0.00906021902346341 DOWN -2.61056075752192 0.0136084344884794 ErbB signaling pathway: ELK1* hsa05200__222 0.00910200300018099 DOWN -2.60898623354272 0.0136602744707189 Pathways in cancer: CASP9* hsa03320__8 0.00914395892276386 DOWN -2.60741170956351 0.01371228955776 PPAR signaling pathway: GK hsa04115__15 0.00931351415881095 UP 2.60111361364669 0.0139554171486489 p53 signaling pathway: TSC2 hsa05200__223 0.00957310866608502 DOWN -2.59166646977146 0.0143215534901065 Pathways in cancer: CCND1**** hsa05221__17 0.00957310866608502 DOWN -2.59166646977146 0.0143215534901065 Acute myeloid leukemia: CCND1 hsa04024__31 0.00966106294153768 UP 2.58851742181305 0.0144186952082203 cAMP signaling pathway: C00165 hsa04024__32 0.00966106294153768 UP 2.58851742181305 0.0144186952082203 cAMP signaling pathway: C01245 hsa04210__10 0.00966106294153768 UP 2.58851742181305 0.0144186952082203 Apoptosis: BIRC2 hsa04022__63 0.0097943452736726 UP 2.58379384987544 0.0146060117216118 cGMP-PKG signaling pathway: C00575 hsa04723__10 0.00992926374380054 UP 2.57907027793782 0.0147837453047553 Retrograde endocannabinoid signaling: CACNA1A hsa04723__21 0.00992926374380054 UP 2.57907027793782 0.0147837453047553 Retrograde endocannabinoid signaling: CACNA1A* hsa04110__96 97 0.0100201267641809 DOWN -2.57592122997941 0.0149072194694346 Cell cycle: TFDP1 E2F4 hsa04623__8 0.0102971752237567 DOWN -2.56647408610418 0.0153072723460751 Cytosolic DNA-sensing pathway: TBK1 hsa04064__52 0.0105332353031508 DOWN -2.55860146620816 0.0156458095925853 NF-kappa B signaling pathway: TRAF1 hsa04213__53 0.0106289991979932 DOWN -2.55545241824975 0.0157755841177166 Longevity regulating pathway - multiple species: SOD1 hsa04921__59 0.0106771708800168 DOWN -2.55387789427054 0.0158345730730477 Oxytocin signaling pathway: CCND1 hsa04910__26 0.0109209530666688 UP 2.54600527437452 0.0161833366027371 Insulin signaling pathway: RPS6 hsa05110__51 0.0112705561194941 UP 2.53498360652008 0.0166882387301257 Vibrio cholerae infection: PDIA4 hsa04726__45 0.0113212593796201 UP 2.53340908254088 0.0167370000420789 Serotonergic synapse: TRPC1 hsa04917__45 0.0113213023169145 UP 2.53340908254088 0.0167370000420789 Prolactin signaling pathway: SLC2A2 hsa04530__13 45 20 0.0113722512775823 UP 2.53183455856167 0.0167991038919631 Tight junction: EPB41 TJP2 ACTB hsa05217__4 0.0117872248035791 DOWN -2.51923836672803 0.0173984252992341 Basal cell carcinoma: PTCH1 hsa04022__9 0.0118400295909459 DOWN -2.51766384274883 0.0174626496086243 cGMP-PKG signaling pathway: ITPR1 hsa04742__54 0.0126575178314366 DOWN -2.49404598306075 0.0186390877784243 Taste transduction: P2RX2* hsa04742__40 0.0126575178314366 DOWN -2.49404598306075 0.0186390877784243 Taste transduction: P2RX2 hsa05205__144 0.0127703681679032 DOWN -2.49089693510234 0.0187905417286532 Proteoglycans in cancer: NUDT16L1 hsa04530__4 37 11 0.0128839657985892 DOWN -2.48774788714393 0.0189428573830588 Tight junction: OCLN TJP3 TJP1 hsa05160__54 0.0129984565677705 DOWN -2.48459883918552 0.0190962469826745 Hepatitis C: IRF1 hsa05145__9 0.0130560387150229 UP 2.48302431520632 0.0191658568324437 Toxoplasmosis: MAPK1 hsa04919__26 0.0132301410612878 DOWN -2.4783007432687 0.0194062724856829 Thyroid hormone signaling pathway: THRB hsa04390__59 0.0135248758813246 DOWN -2.47042812337268 0.0198231215140475 Hippo signaling pathway: SERPINE1 hsa05160__66 0.0135845142058407 UP 2.46885359939347 0.0198950134004479 Hepatitis C: GSK3B hsa05162__27 70 0.0138862040645096 DOWN -2.46098097949745 0.0203210104651196 Measles: STAT1 GNB2L1 hsa04914__29 0.0139471896942811 UP 2.45940645551824 0.0203943731015985 Progesterone-mediated oocyte maturation: CDK2 hsa05169__29 0.0142560284544571 DOWN -2.45153383562222 0.0208297647479975 Epstein-Barr virus infection: FCER2 hsa04520__73 0.0143185034946382 UP 2.44995931164301 0.020904792592405 Adherens junction: PARD3 hsa04810__48 0.0146984500914617 DOWN -2.44051216776778 0.0214428476101371 Regulation of actin cytoskeleton: IQGAP2 hsa04380__38 0.014762631206781 DOWN -2.43893764378858 0.021503088401195 Osteoclast differentiation: FOS hsa04918__14 0.014762631206781 UP 2.43893764378858 0.021503088401195 Thyroid hormone synthesis: DUOX2 hsa05213__13 0.0148270591821527 DOWN -2.43736311980937 0.021580204650089 Endometrial cancer: CASP9 hsa05321__92 0.015351465025067 DOWN -2.42476692797573 0.0223261631440409 Inflammatory bowel disease (IBD): IL17F hsa04340__31 0.0156197390317153 UP 2.41846883205891 0.0226987545557564 Hedgehog signaling pathway: GLI1*** hsa05166__32 0.0156874486586271 DOWN -2.4168943080797 0.0227795332531378 HTLV-I infection: STAT5A hsa05016__60 0.0157554163582709 UP 2.4153197841005 0.0228429223280794 Huntington's disease: CASP3* hsa05134__35 0.0157554163582709 UP 2.4153197841005 0.0228429223280794 Legionellosis: CASP3 hsa04360__81 0.0158921292355394 UP 2.41217073614209 0.0230233699564985 Axon guidance: FYN* hsa04115__20 0.0159608760475983 UP 2.41059621216288 0.0231051510735263 p53 signaling pathway: RRM2B hsa05120__18 0.016308546694466 DOWN -2.40272359226686 0.0235902688521182 Epithelial cell signaling in Helicobacter pylori infection: CCL5 hsa05152__76 0.0163788739189741 DOWN -2.40114906828765 0.0236737723798095 Tuberculosis: TNF* hsa05205__451 0.0164494674429668 DOWN -2.39957454430845 0.0237575321486046 Proteoglycans in cancer: KDR** hsa04072__27 0.0167345212149662 UP 2.39327644839163 0.0241506646412607 Phospholipase D signaling pathway: C01245 hsa05142__67 0.0170239027224702 DOWN -2.38697835247481 0.024549434547599 Chagas disease (American trypanosomiasis): IFNGR1* hsa04950__22 0.0170969306319326 DOWN -2.3854038284956 0.024635837927455 Maturity onset diabetes of the young: NR5A2 hsa04933__22 0.0172438114274702 DOWN -2.38225478053719 0.0248284457258364 AGE-RAGE signaling pathway in diabetic complications: EDN1 hsa04930__15 0.0177666462014669 UP 2.37123311268276 0.0255616601933816 Type II diabetes mellitus: C00031* hsa05200__198 0.017842459709328 DOWN -2.36965858870355 0.0256510954811226 Pathways in cancer: BCL2L1* hsa04310__57 0.0181485554483384 DOWN -2.36336049278673 0.0260712046539968 Wnt signaling pathway: SIAH1 hsa05200__187 0.0182257941701517 UP 2.36178596880753 0.0261621598515776 Pathways in cancer: WNT16* hsa04670__86 0.0183033205572802 DOWN -2.36021144482832 0.0262533887993355 Leukocyte transendothelial migration: ACTB hsa04390__14 0.0186163203556474 DOWN -2.3539133489115 0.0266819725005809 Hippo signaling pathway: AREG hsa04360__89 0.0196661402771061 DOWN -2.33344453718184 0.0281651505950322 Axon guidance: CAMK2A hsa04723__73 0.0199993973904852 UP 2.32714644126502 0.028598833863563 Retrograde endocannabinoid signaling: MAPK14* hsa04723__68 0.0199993973904852 UP 2.32714644126502 0.028598833863563 Retrograde endocannabinoid signaling: MAPK14 hsa03320__9 0.0200834779180945 DOWN -2.32557191728581 0.028653648449582 PPAR signaling pathway: PCK1 hsa04662__29 0.0200834779180945 DOWN -2.32557191728581 0.028653648449582 B cell receptor signaling pathway: RAC1 hsa05014__33 34 0.0200834779180945 DOWN -2.32557191728581 0.028653648449582 Amyotrophic lateral sclerosis (ALS): NEFH PRPH hsa05162__58 0.0204228925922799 DOWN -2.31927382136899 0.0291157930052306 Measles: STAT3 hsa04014__41 0.0205085240191868 UP 2.31769929738979 0.0292157063169462 Ras signaling pathway: RAC1* hsa04151__103 0.0205944684028393 DOWN -2.31612477341058 0.0293159137340417 PI3K-Akt signaling pathway: BCL2* hsa04730__20 0.0207672997618826 DOWN -2.31297572545217 0.0295395581018754 Long-term depression: C00025 hsa04152__81 0.0210289172836421 UP 2.30825215351456 0.0298890586807591 AMPK signaling pathway: LIPE hsa04390__79 0.0211167590002956 UP 2.30667762953535 0.0299685726295736 Hippo signaling pathway: SNAI2 hsa05223__37 0.0211167590002956 DOWN -2.30667762953535 0.0299685726295736 Non-small cell lung cancer: CCND1* hsa04621__6 0.0213822049515402 DOWN -2.30195405759774 0.0302995196862323 NOD-like receptor signaling pathway: NFKB1 hsa05168__9 0.0213822049515402 DOWN -2.30195405759774 0.0302995196862323 Herpes simplex infection: NFKB1 hsa04024__34 0.0215607790374094 DOWN -2.29880500963933 0.0305295431886151 cAMP signaling pathway: ATP2B1 hsa04662__6 0.0216505519606774 DOWN -2.29723048566012 0.0306335746491813 B cell receptor signaling pathway: NFKB1 hsa04152__27 0.021831074327586 DOWN -2.29408143770171 0.0308657552005524 AMPK signaling pathway: ADIPOR1 hsa04612__39 0.0223805224938727 DOWN -2.28463429382648 0.0316187983202908 Antigen processing and presentation: PSME3 hsa04750__90 0.0226597273188133 DOWN -2.27991072188887 0.0319651859099475 Inflammatory mediator regulation of TRP channels: C01245** hsa04920__37 0.0226597273188133 UP 2.27991072188887 0.0319651859099475 Adipocytokine signaling pathway: IRS1 hsa04210__60 0.0231317973433527 UP 2.27203810199284 0.0326066370653862 Apoptosis: BBC3 hsa04970__28 0.0239048334305959 UP 2.2594419101592 0.033671050986574 Salivary secretion: AQP5 hsa04723__9 0.024101611162454 UP 2.25629286220079 0.0338720474003373 Retrograde endocannabinoid signaling: PRKCA hsa04725__20 0.024101611162454 UP 2.25629286220079 0.0338720474003373 Cholinergic synapse: PRKCA hsa04726__18 0.024101611162454 UP 2.25629286220079 0.0338720474003373 Serotonergic synapse: PRKCA hsa04723__7 0.0242005043097483 DOWN -2.25471833822159 0.0339856110598035 Retrograde endocannabinoid signaling: ITPR1 hsa04664__30 0.0243993463539454 DOWN -2.25156929026318 0.0342392619858576 Fc epsilon RI signaling pathway: PRKCA hsa04919__40 0.0244992972587018 DOWN -2.24999476628397 0.0343538653351498 Thyroid hormone signaling pathway: RCAN2 hsa04971__52 53 0.0248012815887573 DOWN -2.24527119434636 0.034751385611689 Gastric acid secretion: EZR ACTB hsa04630__35 0.0252089388993984 DOWN -2.23897309842954 0.0352962713800072 Jak-STAT signaling pathway: MTOR hsa05160__56 0.0253117549156331 UP 2.23739857445033 0.0354138402728775 Hepatitis C: MAPK1 hsa05205__150 0.0254149226431393 UP 2.23582405047113 0.0355317259274247 Proteoglycans in cancer: PRKCA hsa05032__4 0.0261474269318076 UP 2.22480238261669 0.0365286358400495 Morphine addiction: ADCY1 hsa04950__1 0.0264668962042873 DOWN -2.22007881067908 0.0369474724872629 Maturity onset diabetes of the young: HNF1B hsa04152__82 0.0267897320767247 UP 2.21535523874146 0.0373703834982671 AMPK signaling pathway: HMGCR hsa04066__55 0.0268980970372022 UP 2.21378071476226 0.0374937124131327 HIF-1 signaling pathway: ANGPT1 hsa04933__27 0.0270068402442904 DOWN -2.21220619078305 0.0376173853365616 AGE-RAGE signaling pathway in diabetic complications: TNF hsa04930__10 0.027225465599023 DOWN -2.20905714282464 0.037893814711529 Type II diabetes mellitus: C00031 hsa04922__24 0.0275560108365187 UP 2.20433357088703 0.0383254954565645 Glucagon signaling pathway: PFKL hsa05152__129 0.0280027239979367 DOWN -2.19803547497021 0.0389179869764223 Tuberculosis: IFNB1 hsa04724__3 0.0281153076993926 UP 2.196460950991 0.0390455751420242 Glutamatergic synapse: GRIK1 hsa04666__30 44 0.0286840959849764 UP 2.18858833109498 0.0397766910374691 Fc gamma R-mediated phagocytosis: C04637 GSN hsa05031__96 0.0286840959849764 DOWN -2.18858833109498 0.0397766910374691 Amphetamine addiction: PDYN hsa05200__173 0.0289143705611701 UP 2.18543928313657 0.0400369213592031 Pathways in cancer: CCNA1 hsa05221__16 0.0289143705611701 UP 2.18543928313657 0.0400369213592031 Acute myeloid leukemia: CCNA1 hsa04924__52 0.0296147668611244 UP 2.17599213926134 0.0409765441325867 Renin secretion: KCNJ2 hsa04210__105 0.0297329069742912 UP 2.17441761528213 0.0411097367216286 Apoptosis: ACTB hsa05152__81 0.0299704033519509 DOWN -2.17126856732372 0.0414076381605262 Tuberculosis: IFNA1 hsa04261__37 0.0310594209414011 DOWN -2.15709785151088 0.0428807141431981 Adrenergic signaling in cardiomyocytes: CREB3 hsa04917__37 0.0311824938443127 DOWN -2.15552332753167 0.043019020509151 Prolactin signaling pathway: TNFSF11 hsa04022__37 38 0.0315542265503021 DOWN -2.15079975559406 0.0434999205341289 cGMP-PKG signaling pathway: ATP2A1 PLN hsa04950__16 0.031678979171155 UP 2.14922523161485 0.0436398840634899 Maturity onset diabetes of the young: PAX4 hsa05166__89 90 0.0318041545155666 UP 2.14765070763565 0.043780224421062 HTLV-I infection: CHUK IKBKG hsa04666__27 0.0324364113858228 UP 2.13977808773962 0.044617874812563 Fc gamma R-mediated phagocytosis: ARPC5 hsa04210__62 0.032564146672087 UP 2.13820356376042 0.0447608131652169 Apoptosis: TP53AIP1 hsa04071__24 0.0329499407004018 DOWN -2.1334799918228 0.0452579960351279 Sphingolipid signaling pathway: PTEN hsa04066__62 0.0330794052145784 UP 2.1319054678436 0.0454026314084681 HIF-1 signaling pathway: NPPA hsa04068__72 0.0334704142005719 UP 2.12718189590598 0.0459057724692515 FoxO signaling pathway: SMAD2 hsa05221__13 0.0343981720177836 DOWN -2.11616022805155 0.0471438112482972 Acute myeloid leukemia: NFKB1 hsa05321__95 0.0352107962483345 UP 2.10671308417632 0.0482223659989945 Inflammatory bowel disease (IBD): SMAD2 hsa05152__88 89 0.0354852458306806 UP 2.10356403621791 0.0485275506995558 Tuberculosis: ITGAX ITGB2 hsa05132__68 0.0354852872065938 UP 2.10356403621791 0.0485275506995558 Salmonella infection: NOS2 hsa05200__96 0.0367431993776797 DOWN -2.08939332040506 0.0502112520950256 Pathways in cancer: C00416 hsa04015__63 0.0368852841121316 UP 2.08781879642586 0.0503322068603451 Rap1 signaling pathway: GNAI1 hsa04931__137 0.0368852841121316 DOWN -2.08781879642586 0.0503322068603451 Insulin resistance: MLXIP* hsa04014__42 0.0371708577753676 DOWN -2.08466974846745 0.0506850811029868 Ras signaling pathway: PLA2G4B hsa04750__7 0.0374582544383783 DOWN -2.08152070050904 0.0510029420939948 Inflammatory mediator regulation of TRP channels: TRPV1 hsa04750__58 0.0374582544383783 DOWN -2.08152070050904 0.0510029420939948 Inflammatory mediator regulation of TRP channels: TRPV1** hsa05160__71 0.0380388978196156 UP 2.07522260459222 0.0517560383802011 Hepatitis C: MAPK8 hsa04664__23 0.0383320493000682 DOWN -2.07207355663381 0.0521171639904689 Fc epsilon RI signaling pathway: AKT3 hsa04920__6 0.0384793438222981 DOWN -2.0704990326546 0.0522796001750529 Adipocytokine signaling pathway: PTPN11 hsa04726__38 0.0389241169248583 DOWN -2.06577546071699 0.052845676085122 Serotonergic synapse: PLA2G4B hsa04024__3 0.0390733418154289 DOWN -2.06420093673778 0.0530099705929176 cAMP signaling pathway: RYR2 hsa04650__36 0.0393732496170801 DOWN -2.06105188877937 0.0533783088243098 Natural killer cell mediated cytotoxicity: CASP3 hsa04668__128 0.039523934945438 DOWN -2.05947736480017 0.0535053845550994 TNF signaling pathway: CHUK* hsa05211__4 0.039523934945438 UP 2.05947736480017 0.0535053845550994 Renal cell carcinoma: SLC2A1 hsa04520__43 0.0399789311759287 UP 2.05475379286255 0.0540823698197048 Adherens junction: ACTB hsa04370__23 0.0402847243434784 UP 2.05160474490414 0.054456832403882 VEGF signaling pathway: PTK2 hsa04668__48 0.0404383632820598 DOWN -2.05003022092494 0.0546252225787135 TNF signaling pathway: CASP3 hsa04261__8 38 0.0405924987498151 UP 2.04845569694573 0.0547940410566829 Adrenergic signaling in cardiomyocytes: ATP2A2 PLN hsa04210__4 0.0409022641596138 UP 2.04530664898732 0.0551329658220332 Apoptosis: DFFA hsa05169__32 0.0409022641596138 DOWN -2.04530664898732 0.0551329658220332 Epstein-Barr virus infection: CR2 hsa05166__33 0.0417692917566926 DOWN -1.98862378573594 0.056261289756864 HTLV-I infection: HLA-A hsa05321__83 0.0418436044089879 DOWN -2.03585950511209 0.0563210119516391 Inflammatory bowel disease (IBD): IL2 hsa05205__215 216 0.0424812996649932 DOWN -2.02956140919527 0.0571384123625786 Proteoglycans in cancer: EIF4B RPS6 hsa04724__44 0.0426420016838792 UP 2.02798688521607 0.0573135344520808 Glutamatergic synapse: PRKACA* hsa04670__2 0.0428032174628145 DOWN -2.02641236123686 0.0574890962206065 Leukocyte transendothelial migration: MMP2 hsa04910__20 0.0436170462608289 DOWN -2.01853974134084 0.0585403070886411 Insulin signaling pathway: PKLR hsa04810__29 0.04378137072123 DOWN -2.01696521736163 0.0587189119094869 Regulation of actin cytoskeleton: ACTN4 hsa05210__9 11 0.0439462176617706 UP 2.01539069338243 0.0588979621872089 Colorectal cancer: SMAD2 SMAD4 hsa05166__34 35 36 0.0442774203116629 DOWN -2.01224164542402 0.0592574020062661 HTLV-I infection: MYC TRRAP KAT5 hsa03320__66 0.0442774839897805 UP 2.01224164542402 0.0592574020062661 PPAR signaling pathway: UCP1 hsa04650__35 0.045114880969872 DOWN -2.00436902552799 0.0602922200159243 Natural killer cell mediated cytotoxicity: BID hsa05169__118 0.045114880969872 DOWN -2.00436902552799 0.0602922200159243 Epstein-Barr virus infection: MDM2 hsa04610__17 0.0457943765404643 UP 1.99807092961117 0.0611568113145219 Complement and coagulation cascades: PLG hsa03320__27 0.0464824734999396 DOWN -1.99177283369435 0.0620316532005586 PPAR signaling pathway: CPT1C hsa04152__52 0.0470042397404165 DOWN -1.98704926175673 0.0626834396538273 AMPK signaling pathway: PCK1 hsa04726__64 0.0480625618303256 UP 1.9776021178815 0.0640493288504835 Serotonergic synapse: CASP3 hsa04010__107 0.0482408809391813 DOWN -1.9760275939023 0.0642413999183002 MAPK signaling pathway: MAP3K2 hsa04930__26 0.0485991867828791 UP 1.97287854594389 0.0646727138562534 Type II diabetes mellitus: INS* hsa04971__55 0.0487791760896179 DOWN -1.97130402196468 0.0648204185801924 Gastric acid secretion: MYLK4 hsa05231__21 0.0487791760896179 DOWN -1.97130402196468 0.0648204185801924 Choline metabolism in cancer: PCYT1A hsa05216__5 0.0491408339118511 UP 1.96815497400627 0.0652548600143946 Thyroid cancer: MAPK1 hsa04510__42 0.0496875380206401 DOWN -1.96343140206866 0.0659342400711742 Focal adhesion: BIRC2 hsa05216__12 0.0513583417245893 DOWN -1.94926068625581 0.0681032633031075 Thyroid cancer: CDH1 hsa04068__41 0.0519256237294391 DOWN -1.9445371143182 0.0688069442789959 FoxO signaling pathway: CDKN2B hsa04662__16 0.0524981381754514 DOWN -1.93981354238058 0.0694676067828685 B cell receptor signaling pathway: VAV3 hsa04919__11 0.0524981381754514 UP 1.93981354238058 0.0694676067828685 Thyroid hormone signaling pathway: CTNNB1 hsa04010__131 0.0528827388479262 UP 1.93666449442217 0.0699272809959559 MAPK signaling pathway: MYC hsa04662__35 0.0556413828656326 DOWN -1.9146211587133 0.0735233181466411 B cell receptor signaling pathway: CD79B hsa05218__14 0.0564512396024814 UP 1.90832306279648 0.0745410254483925 Melanoma: BAD hsa04630__34 0.0576844041448308 DOWN -1.89887591892125 0.0761158675478491 Jak-STAT signaling pathway: AOX1 hsa04520__44 49 0.0583093352630985 DOWN -1.89415234698364 0.0768864848837629 Adherens junction: ACTB VCL hsa05169__104 0.0585188914243298 UP 1.89257782300443 0.0771086935387909 Epstein-Barr virus infection: IRF3 hsa04015__27 0.0593633807858092 UP 1.88627972708761 0.0781666380494292 Rap1 signaling pathway: RALA hsa04730__30 0.059789403109066 DOWN -1.8831306791292 0.0786724708977136 Long-term depression: C00025* hsa04066__52 0.0615189281241799 DOWN -1.87053448729556 0.0808915786881274 HIF-1 signaling pathway: FLT1 hsa04961__20 0.0623988675975023 DOWN -1.86423639137874 0.0819342524055669 Endocrine and other factor-regulated calcium reabsorption: CALB1* hsa04064__25 0.0623991033487846 DOWN -1.86423639137874 0.0819342524055669 NF-kappa B signaling pathway: NFKB2 hsa05321__138 0.0628430820513516 DOWN -1.86108734342033 0.0824596027754816 Inflammatory bowel disease (IBD): IFNG** hsa05200__80 0.0635139445063062 UP 1.85636377148272 0.083281717883705 Pathways in cancer: TP53 hsa04630__27 0.0646451909906221 DOWN -1.84849115158669 0.0847059371487998 Jak-STAT signaling pathway: PIM1 hsa04012__65 0.0653318842520419 DOWN -1.84376757964908 0.0855460700415239 ErbB signaling pathway: MYC hsa05205__120 0.0667233198570951 UP 1.83432043577385 0.0873071852447644 Proteoglycans in cancer: PLAU hsa04151__63 0.0676644318422512 DOWN -1.82802233985703 0.088477012826437 PI3K-Akt signaling pathway: CASP9 hsa05200__65 0.0688561503088551 DOWN -1.820149719961 0.0899726748472453 Pathways in cancer: STK4 hsa05216__15 0.0690965515304398 DOWN -1.8185751959818 0.090224058600206 Thyroid cancer: CCND1 hsa04151__32 0.0693376418020168 UP 1.81700067200259 0.0904759923236039 PI3K-Akt signaling pathway: BCL2L1 hsa05160__8 0.0698218949979951 DOWN -1.81385162404418 0.0910446500355537 Hepatitis C: NFKB1 hsa05205__77 0.0700649135953196 DOWN -1.81227710006498 0.091298177978922 Proteoglycans in cancer: MIR21 hsa05210__39 0.0717867451419019 DOWN -1.80125543221054 0.0934769883032804 Colorectal cancer: BAD hsa04724__33 70 69 0.0730376184337456 UP 1.79338281231452 0.0950399480865706 Glutamatergic synapse: ITPR1 HOMER3 HOMER3 hsa05161__69 0.0735429358868968 UP 1.79023376435611 0.0956312640356257 Hepatitis B: SMAD4 hsa05213__29 0.074306269636931 DOWN -1.78551019241849 0.0965570405586399 Endometrial cancer: CCND1 hsa04530__1 5 0.0748187466610118 UP 1.78236114446008 0.0970886912817963 Tight junction: IGSF5 IGSF5 hsa04911__54 0.0748187466610118 UP 1.78236114446008 0.0970886912817963 Insulin secretion: RAB3A hsa04912__14 0.0753341068930908 UP 1.77921209650167 0.0976226116221501 GnRH signaling pathway: ATF4 hsa04950__20 0.0753341068930908 DOWN -1.77921209650167 0.0976226116221501 Maturity onset diabetes of the young: NKX6-1 hsa04360__20 0.0758523614148715 DOWN -1.77606304854326 0.0982264556158123 Axon guidance: ROCK1 hsa05200__186 0.0774246016037101 UP 1.76661590466803 0.100193406620779 Pathways in cancer: PTCH1* hsa04370__37 0.0776892048706316 DOWN -1.76504138068883 0.100259626340602 VEGF signaling pathway: CASP9 hsa05110__14 0.0776892048706316 DOWN -1.76504138068883 0.100259626340602 Vibrio cholerae infection: C00238* hsa05110__15 0.0776892048706316 DOWN -1.76504138068883 0.100259626340602 Vibrio cholerae infection: C01330 hsa05110__16 0.0776892048706316 DOWN -1.76504138068883 0.100259626340602 Vibrio cholerae infection: C00698 hsa04971__49 0.0784874365388601 DOWN -1.76031780875121 0.101220242454714 Gastric acid secretion: KCNJ1 hsa04152__58 0.0795621149460756 DOWN -1.75401971283439 0.102535812060134 AMPK signaling pathway: SCD hsa04750__44 0.0809219572118577 UP 1.74614709293837 0.104074547450945 Inflammatory mediator regulation of TRP channels: TRPA1 hsa04750__63 0.0809219572118577 UP 1.74614709293837 0.104074547450945 Inflammatory mediator regulation of TRP channels: TRPA1* hsa04916__15 0.0809222532335445 DOWN -1.74614709293837 0.104074547450945 Melanogenesis: MITF* hsa04024__24 0.0820239044468617 DOWN -1.73984899702155 0.105347174610836 cAMP signaling pathway: PLN hsa05221__26 0.0820239044468617 UP 1.73984899702155 0.105347174610836 Acute myeloid leukemia: BAD hsa04010__15 0.0823012094665626 UP 1.73827447304234 0.105631128816715 MAPK signaling pathway: NFKB1 hsa04012__25 0.0845471143500625 UP 1.7256782812087 0.108439609463322 ErbB signaling pathway: CDKN1B hsa04666__29 0.0848313063990405 DOWN -1.7241037572295 0.108729894081717 Fc gamma R-mediated phagocytosis: WAS hsa04520__10 0.0854020084104121 UP 1.72095470927109 0.109386757875368 Adherens junction: NLK hsa04919__89 0.0856885211521072 DOWN -1.71938018529188 0.109678972237609 Thyroid hormone signaling pathway: CASP9 hsa04152__87 0.0862638770551955 DOWN -1.71623113733347 0.1103402484593 AMPK signaling pathway: CD36 hsa05133__94 0.0871327577992369 UP 1.71150756539586 0.11137581762229 Pertussis: IL12A hsa04931__144 0.0880086881483999 UP 1.70678399345824 0.112418983705536 Insulin resistance: C00533* hsa04014__79 0.0894843396828918 UP 1.69891137356222 0.114226273277278 Ras signaling pathway: RAC1** hsa04151__102 0.0903792522448856 DOWN -1.6941878016246 0.115290302082919 PI3K-Akt signaling pathway: C8orf44-SGK3 hsa05205__304 0.0906791516962383 UP 1.6926132776454 0.115594386728108 Proteoglycans in cancer: MAPK1***** hsa04910__17 0.0909798510907507 UP 1.69103875366619 0.11589907810137 Insulin signaling pathway: C00031 hsa04728__68 0.0918867627946783 DOWN -1.68631518172858 0.116975086240651 Dopaminergic synapse: CACNA1C hsa04742__27 0.0921906758217962 UP 1.68474065774937 0.117282518530234 Taste transduction: CALHM1 hsa04261__14 16 0.0928009238757029 DOWN -1.68159160979096 0.117978982383251 Adrenergic signaling in cardiomyocytes: TNNI3 TPM1 hsa04261__15 17 0.0962154741813434 DOWN -1.66427184601971 0.122237238665818 Adrenergic signaling in cardiomyocytes: ACTC1 MYH6 hsa04668__116 0.0990833499537958 DOWN -1.65010113020686 0.125795685515664 TNF signaling pathway: PGAM5 hsa04728__74 0.0997298300000204 DOWN -1.64695208224845 0.126445580681537 Dopaminergic synapse: GRIN2A hsa04920__43 0.0997298300000204 DOWN -1.64695208224845 0.126445580681537 Adipocytokine signaling pathway: C00162 hsa04912__17 0.100379670001558 UP 1.64380303429004 0.127183681681004 GnRH signaling pathway: MAPK14 hsa04726__71 0.101689473801028 UP 1.63750493837322 0.128756415951571 Serotonergic synapse: CACNA1A hsa05200__49 0.104686286596066 UP 1.62333422256038 0.132461638056571 Pathways in cancer: CASP9 hsa04014__43 0.105023550197914 UP 1.62175969858117 0.132798957484442 Ras signaling pathway: ELK1 hsa04071__11 0.106040517753025 UP 1.61703612664356 0.133994709386641 Sphingolipid signaling pathway: PRKCA hsa05152__13 0.108443814300216 DOWN -1.60601445878912 0.136939467117007 Tuberculosis: LAMP1 hsa05152__51 0.110890008571307 UP 1.59499279093468 0.139934403025847 Tuberculosis: CASP3 hsa04623__17 0.112307272451486 DOWN -1.58869469501786 0.141627761702243 Cytosolic DNA-sensing pathway: NFKB1 hsa04919__18 0.11445990415296 UP 1.57924755114263 0.144245580082771 Thyroid hormone signaling pathway: STAT1 hsa04912__46 0.114821812495008 UP 1.57767302716343 0.144604682089893 GnRH signaling pathway: JUN hsa04668__36 0.115548329549011 DOWN -1.57452397920502 0.145422177644067 TNF signaling pathway: CREB3 hsa04620__29 0.119608976373948 DOWN -1.55720421543376 0.150431905359203 Toll-like receptor signaling pathway: CXCL8 hsa04723__67 0.121491296486621 DOWN -1.54933159553774 0.152697087691211 Retrograde endocannabinoid signaling: PRKACA hsa04550__62 63 0.122631760244509 UP 1.54460802360012 0.154027458221545 Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4 hsa05168__27 0.123013767984317 UP 1.54303349962092 0.15440405480463 Herpes simplex infection: IRF3 hsa05205__236 0.124551099578294 UP 1.5367354037041 0.156229316493734 Proteoglycans in cancer: ITGAV hsa04919__43 0.125713900437644 DOWN -1.53201183176648 0.157582667726707 Thyroid hormone signaling pathway: TBC1D4 hsa04742__48 0.126103374737067 UP 1.53043730778728 0.157965494087299 Taste transduction: GABBR1 hsa04064__95 0.126885142133661 DOWN -1.52728825982887 0.158838895449133 NF-kappa B signaling pathway: BCL2L1** hsa04072__36 0.127277437818215 UP 1.52571373584966 0.159223905233307 Phospholipase D signaling pathway: MTOR hsa04931__13 0.128064859616592 DOWN -1.52256468789125 0.160102376060929 Insulin resistance: AKT2 hsa05016__12 0.129651060988179 DOWN -1.51626659197443 0.161977622072333 Huntington's disease: REST hsa04919__49 0.130049812222822 UP 1.51469206799523 0.162260240283144 Thyroid hormone signaling pathway: ACTB hsa04932__55 0.130049985027363 DOWN -1.51469206799523 0.162260240283144 Non-alcoholic fatty liver disease (NAFLD): CASP3 hsa05032__31 0.130850690507254 DOWN -1.51154302003682 0.162826786399424 Morphine addiction: GABRR3 hsa05032__33 0.130850690507254 DOWN -1.51154302003682 0.162826786399424 Morphine addiction: GABRR3* hsa05032__55 0.130850690507254 DOWN -1.51154302003682 0.162826786399424 Morphine addiction: GABRR3** hsa05223__8 0.130850690507254 DOWN -1.51154302003682 0.162826786399424 Non-small cell lung cancer: CASP9 hsa04550__9 0.132869181920629 UP 1.50367040014079 0.165229115042265 Signaling pathways regulating pluripotency of stem cells: HNF1A hsa05212__12 0.133275757987025 DOWN -1.50209587616159 0.165625098715358 Pancreatic cancer: CASP9 hsa04014__55 0.136978393844759 DOWN -1.48792516034874 0.17011394714759 Ras signaling pathway: MLLT4 hsa04610__11 0.138230084291475 DOWN -1.48320158841113 0.171555038562537 Complement and coagulation cascades: F2R hsa04066__11 0.139912692477868 DOWN -1.47690349249431 0.173528679317435 HIF-1 signaling pathway: SLC2A1 hsa05200__190 0.145490112391374 DOWN -1.45643468076464 0.180327124791155 Pathways in cancer: MYC* hsa04917__34 0.146801066757544 UP 1.45171110882703 0.181832039840096 Prolactin signaling pathway: ELF5 hsa04390__94 0.149895076533248 DOWN -1.44068944097259 0.185542061137005 Hippo signaling pathway: GLI2 hsa04620__18 0.153038579820657 UP 1.42966777311816 0.189183875975667 Toll-like receptor signaling pathway: CXCL11 hsa05217__22 0.153038579820657 UP 1.42966777311816 0.189183875975667 Basal cell carcinoma: LEF1 hsa04530__7 52 0.153491715621089 UP 1.42809324913895 0.189619285767276 Tight junction: PARD6A MPP5 hsa04520__18 0.154401046855627 UP 1.42494420118054 0.190492164833699 Adherens junction: SNAI2 hsa04668__153 0.154401046855627 DOWN -1.42494420118054 0.190492164833699 TNF signaling pathway: MAPK14* hsa05169__83 0.154857244617812 UP 1.42336967720134 0.19092963427616 Epstein-Barr virus infection: GSK3B hsa04931__47 0.155772710233767 UP 1.42022062924293 0.1919324082159 Insulin resistance: AKT2* hsa04670__45 0.156231980400803 UP 1.41864610526372 0.19237214362589 Leukocyte transendothelial migration: PXN hsa05205__69 0.159475676245884 UP 1.40762443740929 0.196237587207607 Proteoglycans in cancer: MAPK1* hsa04921__60 0.160411739394864 UP 1.40447538945088 0.197260247593553 Oxytocin signaling pathway: ELK1 hsa04530__30 0.160881325461958 UP 1.40290086547167 0.197708312977775 Tight junction: AKT3 hsa04072__57 0.161351949361083 UP 1.40132634149247 0.198027637393517 Phospholipase D signaling pathway: C06124 hsa05168__138 0.161351949361083 DOWN -1.40132634149247 0.198027637393517 Herpes simplex infection: CHUK hsa05211__3 0.163244845725684 UP 1.39502824557565 0.200220016395927 Renal cell carcinoma: VEGFA hsa04370__25 0.16372067559725 DOWN -1.39345372159644 0.200672634994933 VEGF signaling pathway: PXN hsa04014__54 0.164197550006837 DOWN -1.39187919761724 0.201125942935363 Ras signaling pathway: RHOA hsa04370__39 0.164675470062582 UP 1.39030467363803 0.201579940226444 VEGF signaling pathway: RAC1 hsa05152__97 0.16515443686986 DOWN -1.38873014965883 0.202034626874002 Tuberculosis: IL18 hsa04340__52 0.169512422956647 UP 1.37455943384598 0.207230867101848 Hedgehog signaling pathway: BCL2* hsa05212__8 0.17049247068263 DOWN -1.37141038588757 0.208293467108363 Pancreatic cancer: NFKB1 hsa04530__11 43 0.170984083703352 UP 1.36983586190837 0.208758345210266 Tight junction: TJP1 ACTN4 hsa04310__22 0.173956077144451 UP 1.36038871803314 0.212249005814561 Wnt signaling pathway: ROCK2 hsa04740__16 0.175456466956515 DOWN -1.35566514609552 0.213940753673778 Olfactory transduction: PRKG1 hsa04911__31 0.176462076803461 UP 1.35251609813711 0.215027394496565 Insulin secretion: CAMK2A hsa04742__31 0.178994886688055 DOWN -1.34464347824109 0.217831212491486 Taste transduction: C00076* hsa05200__205 0.178994886688055 UP 1.34464347824109 0.217831212491486 Pathways in cancer: SLC2A1 hsa05016__55 0.180015546282622 DOWN -1.34149443028268 0.21893152845634 Huntington's disease: TGM2 hsa04360__101 103 0.181554634972619 UP 1.33677085834506 0.22051787919428 Axon guidance: DPYSL2 DPYSL5 hsa05161__214 0.181554634972619 DOWN -1.33677085834506 0.22051787919428 Hepatitis B: CDKN1B hsa04666__49 0.185706578285339 UP 1.32417466651142 0.225415155425162 Fc gamma R-mediated phagocytosis: ARF6* hsa04022__3 0.186755449426557 DOWN -1.32102561855301 0.226395799659678 cGMP-PKG signaling pathway: MYL9 hsa04971__39 0.186755449426557 DOWN -1.32102561855301 0.226395799659678 Gastric acid secretion: EZR hsa04210__72 0.188336951831623 DOWN -1.3163020466154 0.228165784972031 Apoptosis: BCL2A1 hsa04933__35 0.189396761797912 DOWN -1.31315299865699 0.229154227571331 AGE-RAGE signaling pathway in diabetic complications: CCND1 hsa05210__23 0.189396761797912 DOWN -1.31315299865699 0.229154227571331 Colorectal cancer: CCND1 hsa04510__43 0.189928312158065 UP 1.31157847467778 0.229649484263195 Focal adhesion: BAD hsa04620__19 0.190460960702867 UP 1.31000395069858 0.230145430971503 Toll-like receptor signaling pathway: CXCL10 hsa05219__10 0.196392842807197 UP 1.29268418692732 0.237160765832084 Bladder cancer: EGFR hsa05211__21 0.198033872828002 UP 1.28796061498971 0.23898885487721 Renal cell carcinoma: TGFB1* hsa04360__96 0.201345980629034 DOWN -1.27851347111448 0.242829972786878 Axon guidance: GSK3B hsa04310__16 0.203576386473568 DOWN -1.27221537519766 0.24536243116346 Wnt signaling pathway: CAMK2A hsa04670__18 0.204136719779195 DOWN -1.27064085121845 0.245880061836607 Leukocyte transendothelial migration: CDH5 hsa03320__28 0.205824724102854 DOWN -1.26591727928084 0.247754424464614 PPAR signaling pathway: ACSL1 hsa04740__13 0.209230971083116 UP 1.25647013540561 0.251693338454018 Olfactory transduction: CNGA3 hsa05223__22 0.209802625978234 UP 1.2548956114264 0.252219535644979 Non-small cell lung cancer: BAD* hsa04621__42 0.216165580755823 DOWN -1.23757584765515 0.259702766138229 NOD-like receptor signaling pathway: MAPK8 hsa04919__99 0.217924799213446 DOWN -1.23285227571753 0.261481927025584 Thyroid hormone signaling pathway: WNT4 hsa05161__126 0.217924799213446 DOWN -1.23285227571753 0.261481927025584 Hepatitis B: MYC* hsa05205__22 0.218513486146698 UP 1.23127775173833 0.262020957542849 Proteoglycans in cancer: PPP1R12A hsa04066__53 0.219694285709308 UP 1.22812870377992 0.263268853857008 HIF-1 signaling pathway: EGF* hsa05132__41 0.220286399832294 UP 1.22655417980071 0.263810162705469 Salmonella infection: ACTB* hsa05231__39 0.220879657838442 DOWN -1.22497965582151 0.264352151005371 Choline metabolism in cancer: EIF4EBP1 hsa05223__23 0.223264143355145 DOWN -1.21868155990469 0.2670358531918 Non-small cell lung cancer: CASP9* hsa04152__77 0.223863131735056 DOWN -1.21710703592548 0.267411840133611 AMPK signaling pathway: CCND1 hsa04727__35 0.223863131735056 DOWN -1.21710703592548 0.267411840133611 GABAergic synapse: PRKACA hsa04950__15 0.224463268351298 DOWN -1.21553251194628 0.267958374353296 Maturity onset diabetes of the young: IAPP hsa04930__8 0.225666989130266 UP 1.21238346398787 0.269224300048108 Type II diabetes mellitus: C00022 hsa04380__16 0.226875311323531 DOWN -1.20923441602946 0.270494105315301 Osteoclast differentiation: NFKB1 hsa04550__53 64 0.228088240492665 DOWN -1.20608536807105 0.271767789401216 Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4 hsa04012__24 0.229305782128902 DOWN -1.20293632011264 0.273045351470347 ErbB signaling pathway: CDKN1A hsa05168__122 0.230527941652705 UP 1.19978727215422 0.274326790605088 Herpes simplex infection: CASP3 hsa04650__16 0.23608494761002 DOWN -1.18561655634138 0.280406837268792 Natural killer cell mediated cytotoxicity: PRKCA hsa04913__36 0.23608494761002 DOWN -1.18561655634138 0.280406837268792 Ovarian steroidogenesis: CYP19A1 hsa04913__37 0.23608494761002 DOWN -1.18561655634138 0.280406837268792 Ovarian steroidogenesis: CYP19A1* hsa04152__62 0.239212799430001 DOWN -1.17774393644535 0.2839424195382 AMPK signaling pathway: EIF4EBP1 hsa05140__16 0.242369767621909 UP 1.16987131654933 0.287508076617151 Leishmaniasis: STAT1 hsa05110__13 0.243640511919503 DOWN -1.16672226859092 0.288833136843372 Vibrio cholerae infection: C00238 hsa04961__5 0.253322216381875 DOWN -1.14310440890284 0.300121339584832 Endocrine and other factor-regulated calcium reabsorption: TRPV5 hsa05152__98 0.255948591235868 UP 1.13680631298602 0.303041841797225 Tuberculosis: IL23A hsa04550__47 0.257268848672343 UP 1.13365726502761 0.304413203183459 Signaling pathways regulating pluripotency of stem cells: CTNNB1* hsa04380__69 0.259923522348773 UP 1.12735916911079 0.307360792003363 Osteoclast differentiation: NFKB2 hsa04740__42 0.260590143177447 DOWN -1.12578464513159 0.307955269830454 Olfactory transduction: PDE2A hsa04360__11 0.270047121339073 DOWN -1.10374130942272 0.318930572593412 Axon guidance: NFATC2 hsa04115__18 0.274862824252108 DOWN -1.09271964156828 0.324414099729718 p53 signaling pathway: CCNG1 hsa05160__53 0.276944539228687 DOWN -1.08799606963067 0.326460971901319 Hepatitis C: EIF2S1 hsa05162__74 0.276944539228687 DOWN -1.08799606963067 0.326460971901319 Measles: EIF2S1 hsa05214__23 0.281843570056011 UP 1.07697440177623 0.331819591563437 Glioma: MAPK1 hsa05214__56 0.281843570056011 UP 1.07697440177623 0.331819591563437 Glioma: MAPK1* hsa04932__138 0.282548201213536 DOWN -1.07539987779703 0.332440870432206 Non-alcoholic fatty liver disease (NAFLD): CEBPA hsa04727__17 37 0.283254025618284 DOWN -1.07382535381782 0.333062774803977 GABAergic synapse: GABRA1 GPHN hsa04668__138 0.284669255235579 DOWN -1.07067630585941 0.334517530073579 TNF signaling pathway: NFKB1* hsa05169__93 0.288228229186702 DOWN -1.06280368596339 0.338488026651133 Epstein-Barr virus infection: PLCG1 hsa04024__2 0.292538442771712 DOWN -1.05335654208816 0.34333524919928 cAMP signaling pathway: CACNA1C hsa04911__25 0.293260998263062 UP 1.05178201810895 0.343753846373233 Insulin secretion: PRKCA hsa05221__29 0.293260998263062 DOWN -1.05178201810895 0.343753846373233 Acute myeloid leukemia: RPS6KB1 hsa04012__37 7 0.293984750440749 DOWN -1.05020749412975 0.343958496935347 ErbB signaling pathway: ERBB3 ERBB3 hsa04912__43 0.293984750440749 UP 1.05020749412975 0.343958496935347 GnRH signaling pathway: PTK2B hsa05145__8 0.293984750440749 DOWN -1.05020749412975 0.343958496935347 Toxoplasmosis: NFKB1 hsa05216__14 0.297621467891116 UP 1.04233487423372 0.34799672567978 Thyroid cancer: MAPK1* hsa05200__196 0.298352403867837 DOWN -1.04076035025452 0.348634432131633 Pathways in cancer: TRAF1 hsa04913__45 0.299817869547843 DOWN -1.03761130229611 0.350129134170539 Ovarian steroidogenesis: ACOT2 hsa04064__137 0.302763179675097 UP 1.03131320637929 0.35334907739721 NF-kappa B signaling pathway: ICAM1 hsa04660__30 0.304984747584219 UP 1.02658963444167 0.355720881881283 T cell receptor signaling pathway: CD40LG hsa04918__10 0.305727668005516 DOWN -1.02501511046247 0.356366183735958 Thyroid hormone synthesis: TG hsa05152__9 0.314736260035519 UP 1.00612082271201 0.366412287860434 Tuberculosis: TCIRG1 hsa05161__57 0.314736260035519 DOWN -1.00612082271201 0.366412287860434 Hepatitis B: STAT3* hsa05221__5 0.317015399040496 UP 1.00139725077439 0.368837111329469 Acute myeloid leukemia: SPI1 hsa04012__57 0.317777511534687 DOWN -0.999822726795187 0.369495014958959 ErbB signaling pathway: ABL1 hsa04210__70 0.319305335766746 UP 0.996673678836777 0.371041883677004 Apoptosis: CFLAR* hsa04014__35 0.321606070035131 UP 0.991950106899162 0.373484428674914 Ras signaling pathway: NFKB1 hsa04742__47 0.323145782340358 DOWN -0.988801058940752 0.374809339246624 Taste transduction: GABRA1 hsa05205__45 46 0.32314589120784 UP 0.988801058940752 0.374809339246624 Proteoglycans in cancer: PAK1 FLNA hsa04064__136 0.324690510687177 DOWN -0.985652010982342 0.375904787172647 NF-kappa B signaling pathway: TNFSF13B* hsa04340__46 0.324690510687177 DOWN -0.985652010982342 0.375904787172647 Hedgehog signaling pathway: PRKACA hsa04727__8 0.324690510687177 UP 0.985652010982342 0.375904787172647 GABAergic synapse: ADCY1 hsa03320__29 0.329353154355307 UP 0.976204867107112 0.380833585866844 PPAR signaling pathway: OLR1 hsa04710__5 0.329353154355307 DOWN -0.976204867107112 0.380833585866844 Circadian rhythm: RORA hsa05223__9 0.334847458332674 UP 0.965183199252677 0.386948569623059 Non-small cell lung cancer: BAD hsa05110__52 0.338013423891434 DOWN -0.958885103335857 0.390367070370009 Vibrio cholerae infection: ADCY3 hsa04925__5 0.341198551185881 DOWN -0.952587007419037 0.393803487517365 Aldosterone synthesis and secretion: KCNK3 hsa04722__33 0.344402829087754 DOWN -0.946288911502217 0.397257775233819 Neurotrophin signaling pathway: BAD hsa04919__91 0.347626244878096 UP 0.939990815585397 0.400729885966836 Thyroid hormone signaling pathway: PFKP hsa05145__35 0.350056357407515 DOWN -0.935267243647782 0.403283810894372 Toxoplasmosis: CASP3 hsa04261__62 0.351682405306751 UP 0.932118195689372 0.404660893797541 Adrenergic signaling in cardiomyocytes: BCL2 hsa04910__39 0.351682405306751 UP 0.932118195689372 0.404660893797541 Insulin signaling pathway: BAD hsa05220__25 0.355768414700871 UP 0.924245575793347 0.409111904053205 Chronic myeloid leukemia: BCL2L1* hsa04390__60 0.357411168363036 UP 0.921096527834936 0.410749593488773 Hippo signaling pathway: CTGF* hsa04380__68 0.36071097642758 DOWN -0.914798431918116 0.4142884625351 Osteoclast differentiation: TGFBR1 hsa05168__123 0.363198335341795 UP 0.910074859980501 0.416890453333679 Herpes simplex infection: CYCS hsa04912__26 0.36486252320398 UP 0.906925812022091 0.418544982356703 GnRH signaling pathway: PLD1 hsa05169__60 0.368205162402309 UP 0.900627716105271 0.42212172065524 Epstein-Barr virus infection: NFKB1 hsa05152__23 0.374947406856626 DOWN -0.888031524271631 0.429589132611951 Tuberculosis: PPP3CA hsa04530__11 36 14 0.380053828538093 UP 0.878584380396401 0.435174371616744 Tight junction: TJP1 CTNNB1 CTNNA1 hsa04390__77 0.380909035713101 DOWN -0.877009856417196 0.435887989101654 Hippo signaling pathway: CCND1 hsa04728__64 0.383481739366545 UP 0.872286284479581 0.438564935039403 Dopaminergic synapse: SCN1A hsa04062__40 0.384341666285422 UP 0.870711760500376 0.439281016393132 Chemokine signaling pathway: PRKACA hsa05032__30 0.385202700586284 DOWN -0.869137236521171 0.439997492037463 Morphine addiction: ADORA1 hsa04621__29 0.387793155339363 DOWN -0.864413664583556 0.442687326174158 NOD-like receptor signaling pathway: CASP5 hsa05152__24 25 0.393878394154769 DOWN -0.853391996729121 0.449360960908811 Tuberculosis: ITGB2 ITGAM hsa04620__86 0.394752571011295 UP 0.851817472749916 0.450085000564456 Toll-like receptor signaling pathway: IL12A hsa04151__98 0.398260424476192 UP 0.845519376833096 0.453809179860985 PI3K-Akt signaling pathway: BCL2L1* hsa04621__30 32 0.399140313183453 UP 0.843944852853891 0.454260840988315 NOD-like receptor signaling pathway: PYCARD CASP1 hsa05210__16 0.399140313183453 UP 0.843944852853891 0.454260840988315 Colorectal cancer: MAPK8 hsa03320__56 0.400903596636507 DOWN -0.84079580489548 0.455991439515736 PPAR signaling pathway: FADS2 hsa04921__46 0.402671550545514 UP 0.83764675693707 0.457725253160933 Oxytocin signaling pathway: C00942* hsa03320__33 0.408003382401251 UP 0.82819961306184 0.463505656307104 PPAR signaling pathway: CYP7A1 hsa04620__77 0.409789964994635 DOWN -0.82505056510343 0.465253984425933 Toll-like receptor signaling pathway: CXCL9 hsa04920__28 0.412478543382557 UP 0.820326993165815 0.46802366124144 Adipocytokine signaling pathway: SLC2A1 hsa04370__38 0.413377054500964 UP 0.81875246918661 0.468760099823362 VEGF signaling pathway: BAD hsa05161__68 0.415177549825711 DOWN -0.8156034212282 0.470517862558812 Hepatitis B: JUN hsa04621__44 0.416079532543393 UP 0.814028897248995 0.471255841861986 NOD-like receptor signaling pathway: MAPK14 hsa04360__35 0.419699012769251 UP 0.807730801332175 0.474782928954499 Axon guidance: ROCK1* hsa05200__202 0.419699012769251 UP 0.807730801332175 0.474782928954499 Pathways in cancer: FIGF* hsa04550__34 0.42151567167593 DOWN -0.804581753373765 0.47655111135925 Signaling pathways regulating pluripotency of stem cells: MAPK1* hsa04742__18 0.423336934707437 UP 0.801432705415355 0.478322369401848 Taste transduction: PDE1A hsa05145__10 0.426993247287084 UP 0.795134609498535 0.482163648829585 Toxoplasmosis: MAPK8 hsa04064__93 0.428828283637346 UP 0.791985561540125 0.483944951924668 NF-kappa B signaling pathway: PLAU hsa04066__37 0.43066789771653 DOWN -0.788836513581715 0.485729279597455 HIF-1 signaling pathway: PDHA1 hsa05161__125 0.433435887023318 UP 0.7841129416441 0.488557907448599 Hepatitis B: CDKN1A hsa04919__101 0.434360831480948 UP 0.782538417664895 0.489306955846944 Thyroid hormone signaling pathway: NOTCH1 hsa05164__47 0.435286915140443 UP 0.78096389368569 0.490056389184477 Influenza A: CIITA hsa05140__43 0.436214137106188 DOWN -0.779389369706485 0.490806205761992 Leishmaniasis: MAPK14 hsa05134__72 0.437142496475825 DOWN -0.77781484572728 0.491556403876766 Legionellosis: IL12A hsa04020__16 0.442736486792543 DOWN -0.76836770185205 0.497548958542577 Calcium signaling pathway: C06124 hsa04530__20 31 0.44367278215617 UP 0.766793177872845 0.498303142660755 Tight junction: ACTB MLLT4 hsa04920__3 0.444610207461695 UP 0.76521865389364 0.499057694038545 Adipocytokine signaling pathway: C15493 hsa05200__121 122 0.44554876174596 UP 0.763644129914435 0.499514393389414 Pathways in cancer: SMAD2 SMAD4 hsa05212__38 39 0.44554876174596 UP 0.763644129914435 0.499514393389414 Pancreatic cancer: SMAD2 SMAD4 hsa04071__89 0.446488444039045 DOWN -0.76206960593523 0.499971267192709 Sphingolipid signaling pathway: C00533 hsa04340__13 0.446488444039045 UP 0.76206960593523 0.499971267192709 Hedgehog signaling pathway: GLI1* hsa04621__4 7 8 0.450258433664536 UP 0.755771510018409 0.503892553219573 NOD-like receptor signaling pathway: IKBKG CHUK IKBKB hsa03320__60 0.455947089237113 DOWN -0.746324366143179 0.509955107545557 PPAR signaling pathway: CYP27A1 hsa04916__6 0.456899113678134 UP 0.744749842163974 0.510715903986445 Melanogenesis: DCT hsa04540__16 17 0.457852253961317 DOWN -0.743175318184769 0.511477042326584 Gap junction: GJA1 GJA1** hsa04520__1 13 0.461675952256719 DOWN -0.736877222267949 0.515442135644905 Adherens junction: SMAD4 SMAD2 hsa04920__31 0.464555389810152 UP 0.732153650330334 0.518348917727599 Adipocytokine signaling pathway: AGRP hsa04530__20 37 0.467444792030196 UP 0.727430078392719 0.521263361557708 Tight junction: ACTB TJP3 hsa04012__22 0.46841013526873 UP 0.725855554413514 0.522030038060465 ErbB signaling pathway: EIF4EBP1 hsa04210__107 0.470344128709885 UP 0.722706506455104 0.523874699375147 Apoptosis: MCL1 hsa05166__5 0.473253369094322 UP 0.717982934517489 0.526802772824781 HTLV-I infection: SLC2A1 hsa04010__86 0.480079934204366 UP 0.706961266663054 0.534085373812909 MAPK signaling pathway: MAP4K2 hsa05205__142 0.48400480376952 DOWN -0.700663170746234 0.538133151646704 Proteoglycans in cancer: CTNNB1 hsa04066__45 0.485973745479576 DOWN -0.697514122787824 0.540002760352527 HIF-1 signaling pathway: ALDOA hsa04066__51 0.498876822614842 UP 0.677045311058158 0.554012736225348 HIF-1 signaling pathway: TFRC hsa05016__22 9 0.503887594015278 DOWN -0.669172691162133 0.559246774456413 Huntington's disease: DLG4 HTT hsa04071__66 0.505899314257551 UP 0.666023643203723 0.561148058730778 Sphingolipid signaling pathway: C01245 hsa04530__11 62 0.51195974226473 DOWN -0.656576499328493 0.567200681435983 Tight junction: TJP1 SHROOM1 hsa04933__29 0.51195974226473 UP 0.656576499328493 0.567200681435983 AGE-RAGE signaling pathway in diabetic complications: ICAM1 hsa04152__103 0.523168119266477 UP 0.639256735557238 0.578935745642938 AMPK signaling pathway: ULK1 hsa05205__319 0.523168119266477 UP 0.639256735557238 0.578935745642938 Proteoglycans in cancer: KDR hsa04950__11 0.52521945464471 DOWN -0.636107687598828 0.580863658197417 Maturity onset diabetes of the young: HNF4G hsa04211__29 0.527274898140975 DOWN -0.632958639640418 0.582793843298172 Longevity regulating pathway - mammal: EIF4E hsa04621__43 0.528304156626131 DOWN -0.631384115661213 0.583245305699471 NOD-like receptor signaling pathway: MAPK1 hsa05205__34 0.528304156626131 UP 0.631384115661213 0.583245305699471 Proteoglycans in cancer: SLC9A1 hsa05161__26 0.53243139959947 UP 0.625086019744393 0.587456605899827 Hepatitis B: MMP9 hsa04310__14 0.533465754846331 UP 0.623511495765188 0.588252437415644 Wnt signaling pathway: PRKCA hsa04666__50 52 0.535537507795634 UP 0.620362447806778 0.590190602432842 Fc gamma R-mediated phagocytosis: DNM2 AMPH hsa05200__226 0.537613306826524 DOWN -0.617213399848368 0.592130951657115 Pathways in cancer: CDKN1A* hsa04024__92 0.538652719650768 UP 0.615638875869163 0.592928213370705 cAMP signaling pathway: GRIN3A hsa04261__15 16 0.540734563915935 DOWN -0.612489827910753 0.594871338172156 Adrenergic signaling in cardiomyocytes: ACTC1 TPM1 hsa05162__101 0.541776992136861 UP 0.610915303931548 0.595669378715718 Measles: CDKN1B hsa05214__27 0.542820422259126 UP 0.609340779952343 0.596118979208006 Glioma: MTOR hsa05214__48 0.542820422259126 UP 0.609340779952343 0.596118979208006 Glioma: MTOR* hsa05215__24 0.547004129137261 UP 0.603042684035523 0.600362592668758 Prostate cancer: CDKN1A hsa04725__18 0.551203735158312 UP 0.596744588118702 0.604618691396654 Cholinergic synapse: ITPR1 hsa05222__36 0.552256108426651 UP 0.595170064139497 0.605419619447886 Small cell lung cancer: PTGS2 hsa05161__29 0.554363809308104 UP 0.592021016181087 0.607375858711327 Hepatitis B: NFKB1 hsa04360__29 0.555419133532232 DOWN -0.590446492201882 0.607823268437428 Axon guidance: RASA1 hsa05220__19 41 0.555419133532232 UP 0.590446492201882 0.607823268437428 Chronic myeloid leukemia: SMAD4 SMAD3 hsa04912__15 0.55965021581223 UP 0.584148396285062 0.612097063743411 GnRH signaling pathway: CAMK2A hsa04210__119 0.566026005269916 DOWN -0.574701252409832 0.618710217511443 Apoptosis: BCL2* hsa04933__61 0.568158990060259 UP 0.571552204451422 0.620680664141411 AGE-RAGE signaling pathway in diabetic complications: MMP2 hsa04270__65 0.569226893331619 UP 0.569977680472217 0.621485957333012 Vascular smooth muscle contraction: NPR2 hsa04390__58 0.572436456913015 UP 0.565254108534602 0.624627237247128 Hippo signaling pathway: SMAD7 hsa04728__32 0.573508208418322 DOWN -0.563679584555397 0.62543350180965 Dopaminergic synapse: CREB3 hsa04390__12 0.57458091022441 UP 0.562105060576192 0.626239866770108 Hippo signaling pathway: CTGF hsa03320__65 0.576729157456196 DOWN -0.558956012617782 0.628216861947937 PPAR signaling pathway: ME1 hsa04630__33 0.577804699224755 DOWN -0.557381488638577 0.629023771635756 Jak-STAT signaling pathway: RAF1 hsa04740__39 0.57888118397983 UP 0.555806964659372 0.629466287441031 Olfactory transduction: PRKG1* hsa05200__53 0.57888118397983 DOWN -0.555806964659372 0.629466287441031 Pathways in cancer: BCL2L1 hsa05205__17 0.581036975066013 DOWN -0.552657916700962 0.631445041150398 Proteoglycans in cancer: AKT3 hsa04919__84 0.583196515884951 UP 0.549508868742552 0.633059649536582 Thyroid hormone signaling pathway: TP53* hsa05200__204 0.583196515884951 DOWN -0.549508868742552 0.633059649536582 Pathways in cancer: TGFB1* hsa04620__20 0.587526786901056 DOWN -0.543210772825732 0.637391935673837 Toll-like receptor signaling pathway: IFNB1* hsa04728__71 72 0.589697486938589 UP 0.540061724867322 0.639377713766652 Dopaminergic synapse: CLOCK ARNTL hsa05145__67 0.59732389037121 UP 0.529040057012887 0.647273119958191 Toxoplasmosis: BAD hsa04630__7 0.601701872119028 UP 0.522741961096067 0.651266024027451 Jak-STAT signaling pathway: BCL2 hsa04919__32 0.601701872119028 UP 0.522741961096067 0.651266024027451 Thyroid hormone signaling pathway: PLN hsa04350__50 0.603896276713696 UP 0.519592913137656 0.652889012626602 TGF-beta signaling pathway: AMHR2 hsa04932__14 0.603896276713696 UP 0.519592913137656 0.652889012626602 Non-alcoholic fatty liver disease (NAFLD): PKLR hsa04014__33 0.606094269330625 UP 0.516443865179246 0.654888517580359 Ras signaling pathway: BCL2L1 hsa04066__42 0.608295834004597 DOWN -0.513294817220836 0.656889581663584 HIF-1 signaling pathway: HK1 hsa04933__28 0.610500954673547 DOWN -0.510145769262426 0.658892184854448 AGE-RAGE signaling pathway in diabetic complications: VCAM1 hsa04664__46 0.614921799265817 UP 0.503847673345606 0.663282468898089 Fc epsilon RI signaling pathway: PLA2G4B hsa04390__52 0.616029207546535 UP 0.502273149366401 0.664095743534102 Hippo signaling pathway: ITGB2 hsa05010__51 0.617137490583683 DOWN -0.500698625387196 0.664909027985516 Alzheimer's disease: ATF6 hsa04913__47 0.622691954851307 DOWN -0.492826005491171 0.669741375595653 Ovarian steroidogenesis: INSR hsa04913__51 0.622691954851307 DOWN -0.492826005491171 0.669741375595653 Ovarian steroidogenesis: INSR* hsa04924__30 0.622691954851307 UP 0.492826005491171 0.669741375595653 Renin secretion: PDE3A hsa04919__100 0.63050436270883 UP 0.481804337636736 0.677368609222351 Thyroid hormone signaling pathway: CTNNB1* hsa05161__48 0.63050436270883 DOWN -0.481804337636736 0.677368609222351 Hepatitis B: STAT1 hsa04620__23 0.633865292863297 UP 0.477080765699121 0.680201533575177 Toll-like receptor signaling pathway: CD40 hsa04630__24 0.633865292863297 UP 0.477080765699121 0.680201533575177 Jak-STAT signaling pathway: MCL1 hsa04971__37 0.634987287992174 UP 0.475506241719916 0.681016617658273 Gastric acid secretion: KCNQ1 hsa05145__23 0.636110122076839 DOWN -0.473931717740711 0.681831671068101 Toxoplasmosis: CIITA hsa04115__24 0.638358298474146 DOWN -0.470782669782301 0.68385133570862 p53 signaling pathway: SERPINB5 hsa04924__58 0.639483636452707 UP 0.469208145803096 0.684276624655261 Renin secretion: PPP3CA hsa05031__59 0.639483636452707 UP 0.469208145803096 0.684276624655261 Amphetamine addiction: PPP3CA hsa05166__83 0.6439932694012 UP 0.462910049886276 0.688709933525814 HTLV-I infection: NFKB2 hsa05205__145 0.655324548071893 DOWN -0.447164810094226 0.700429366227012 Proteoglycans in cancer: PXN hsa04270__28 0.658739618726484 DOWN -0.442441238156611 0.703279399765377 Vascular smooth muscle contraction: KCNMB2 hsa04340__51 0.658739618726484 UP 0.442441238156611 0.703279399765377 Hedgehog signaling pathway: CCND1* hsa04630__28 0.662161821271325 DOWN -0.437717666218995 0.706531551487121 Jak-STAT signaling pathway: CCND1 hsa04919__87 0.663304129679665 UP 0.43614314223979 0.707348728528995 Thyroid hormone signaling pathway: BAD hsa04270__46 0.664447221383873 DOWN -0.434568618260585 0.708165813375097 Vascular smooth muscle contraction: ITPR1* hsa05161__30 0.666735745479686 UP 0.431419570302175 0.710202078093158 Hepatitis B: MYC hsa04620__21 0.669027375103988 DOWN -0.428270522343765 0.7122393415413 Toll-like receptor signaling pathway: IFNA1 hsa04071__68 0.670174348698492 UP 0.42669599836456 0.713056399323027 Sphingolipid signaling pathway: NFKB1 hsa05132__8 0.678224576766003 DOWN -0.415674330510125 0.721213344506689 Salmonella infection: TJP1 hsa04662__32 51 0.685154168978769 DOWN -0.406227186634895 0.728170069859224 B cell receptor signaling pathway: BLNK GRB2 hsa04115__55 0.688628969785701 DOWN -0.40150361469728 0.731036064535216 p53 signaling pathway: SHISA5 hsa05200__191 0.688628969785701 UP 0.40150361469728 0.731036064535216 Pathways in cancer: CCND1* hsa05212__10 0.689788702909489 UP 0.399929090718075 0.731853739563483 Pancreatic cancer: BCL2L1 hsa04931__67 0.690949011229274 UP 0.39835456673887 0.73267110163646 Insulin resistance: IKBKB** hsa04931__77 0.695597930817429 DOWN -0.39205647082205 0.737184721943569 Insulin resistance: PPP2R4** hsa04530__11 13 0.696762327290693 UP 0.390481946842845 0.738002487586929 Tight junction: TJP1 EPB41 hsa04650__14 0.70259335107354 UP 0.38260932694682 0.743759384037849 Natural killer cell mediated cytotoxicity: CSF2 hsa04530__11 33 0.70376167220705 UP 0.381034802967615 0.744576679097436 Tight junction: TJP1 CGN hsa05132__86 0.704930693034077 UP 0.37946027898841 0.745393794153647 Salmonella infection: MYH9 hsa04650__119 0.70610041107378 DOWN -0.377885755009205 0.746210726888432 Natural killer cell mediated cytotoxicity: KLRC4-KLRK1 hsa04390__75 0.708441928843166 UP 0.374736707050795 0.747844036121522 Hippo signaling pathway: NKD1 hsa04530__5 11 31 0.708441928843166 DOWN -0.374736707050795 0.747844036121522 Tight junction: IGSF5 TJP1 MLLT4 hsa04722__38 0.710786205569991 UP 0.371587659092385 0.749897406101075 Neurotrophin signaling pathway: ATF4 hsa04666__23 0.714307749882823 UP 0.36686408715477 0.753189821565558 Fc gamma R-mediated phagocytosis: RPS6KB1 hsa05321__152 0.715482955724347 DOWN -0.365289563175565 0.754005874260263 Inflammatory bowel disease (IBD): FOXP3* hsa04622__6 0.716658836230647 DOWN -0.36371503919636 0.754821722689118 RIG-I-like receptor signaling pathway: NFKB1 hsa04370__15 0.71783538887221 DOWN -0.362140515217155 0.755214275302846 VEGF signaling pathway: PLA2G4B hsa04919__21 53 0.71783538887221 DOWN -0.362140515217155 0.755214275302846 Thyroid hormone signaling pathway: THRA C02465 hsa05213__12 0.720190500419198 UP 0.358991467258744 0.757268019187281 Endometrial cancer: BAD hsa04931__46 0.724908677309279 DOWN -0.352693371341924 0.761802799029158 Insulin resistance: PIK3R5* hsa05211__2 0.737937146472867 DOWN -0.335373607570669 0.775060871001966 Renal cell carcinoma: TGFB1 hsa04014__62 0.743884417882995 UP 0.327500987674644 0.780870849833602 Ras signaling pathway: RASSF5 hsa05100__15 0.749847005838387 UP 0.319628367778619 0.786690409810346 Bacterial invasion of epithelial cells: CTNNA1 hsa04151__2 0.753431772952335 UP 0.314904795841004 0.790010212822231 PI3K-Akt signaling pathway: EIF4E hsa04390__96 0.757021862926791 UP 0.310181223903389 0.793331890931088 Hippo signaling pathway: FGF1 hsa04360__19 0.760617203444977 DOWN -0.305457651965774 0.796655365258145 Axon guidance: CDC42 hsa03320__31 0.761816804523582 UP 0.303883127986569 0.797467284512429 PPAR signaling pathway: CD36 hsa04072__3 0.763016978226368 UP 0.302308604007364 0.798278898712331 Phospholipase D signaling pathway: MAPK1 hsa04015__95 0.765419032686541 DOWN -0.299159556048954 0.800346334122432 Rap1 signaling pathway: THBS1 hsa05142__53 0.769026341338508 UP 0.294435984111339 0.803671020787017 Chagas disease (American trypanosomiasis): AKT3 hsa04612__18 0.771434000016874 DOWN -0.291286936152929 0.805739013914234 Antigen processing and presentation: KIR2DS2 hsa04022__66 0.777462739209429 DOWN -0.283414316256904 0.811584714985843 cGMP-PKG signaling pathway: PDE3A hsa04310__32 0.779878014267124 UP 0.280265268298493 0.813653963802291 Wnt signaling pathway: PPARD hsa04340__32 0.781086450649256 UP 0.278690744319288 0.814462508751361 Hedgehog signaling pathway: PTCH1*** hsa04620__22 0.785925457347632 DOWN -0.272392648402468 0.819053762815419 Toll-like receptor signaling pathway: CD86 hsa04014__38 0.787136510451117 UP 0.270818124423263 0.819406926946066 Ras signaling pathway: MAPK8 hsa04919__42 0.787136510451117 DOWN -0.270818124423263 0.819406926946066 Thyroid hormone signaling pathway: SLC2A1 hsa05164__68 0.791985845116604 DOWN -0.264520028506443 0.823998562001162 Influenza A: EIF2S1 hsa04151__33 0.793199445388624 UP 0.262945504527238 0.824804514601673 PI3K-Akt signaling pathway: TP53 hsa04910__57 0.796843241262739 DOWN -0.258221932589623 0.828135204830026 Insulin signaling pathway: GCK hsa04910__12 0.799274906305844 DOWN -0.255072884631213 0.830203177970526 Insulin signaling pathway: FASN hsa04931__40 0.800491470720249 DOWN -0.253498360652008 0.830548577296161 Insulin resistance: PRKCZ hsa05213__27 0.800491470720249 DOWN -0.253498360652008 0.830548577296161 Endometrial cancer: ELK1 hsa04024__118 0.804144057657952 UP 0.248774788714393 0.8338778611144 cAMP signaling pathway: MYL9 hsa04919__45 0.806581498727556 DOWN -0.245625740755983 0.835483261361124 Thyroid hormone signaling pathway: SLC9A1 hsa04972__51 0.806581498727556 DOWN -0.245625740755983 0.835483261361124 Pancreatic secretion: CLCA1 hsa04919__38 0.816349835255225 UP 0.233029548922343 0.845135724762847 Thyroid hormone signaling pathway: TP53 hsa04630__30 0.818796448256048 DOWN -0.229880500963933 0.847201831648191 Jak-STAT signaling pathway: CDKN1A hsa04923__31 0.826146789225363 UP 0.220433357088703 0.854336718191776 Regulation of lipolysis in adipocytes: PRKACA* hsa04670__10 0.828600326626639 DOWN -0.217284309130293 0.855931838225099 Leukocyte transendothelial migration: BCAR1 hsa05222__19 0.828600326626639 DOWN -0.217284309130293 0.855931838225099 Small cell lung cancer: CASP9 hsa04910__18 0.82982772426188 UP 0.215709785151088 0.856728732905534 Insulin signaling pathway: LIPE hsa04722__34 0.843355875695475 DOWN -0.198390021379832 0.869739676417013 Neurotrophin signaling pathway: GSK3B hsa05205__256 0.843355875695475 UP 0.198390021379832 0.869739676417013 Proteoglycans in cancer: ACTB hsa04210__61 0.847053584974372 DOWN -0.193666449442217 0.87307388160551 Apoptosis: APAF1 hsa04930__3 0.85075466468636 DOWN -0.188942877504602 0.87640790293074 Type II diabetes mellitus: SLC2A4 hsa05164__65 66 0.855694542952653 DOWN -0.182644781587782 0.881013723949608 Influenza A: DNAJC3 HSPA1A hsa04972__21 0.86064008236134 DOWN -0.176346685670962 0.885620325715749 Pancreatic secretion: KCNQ1 hsa04933__78 0.865591093010043 DOWN -0.170048589754142 0.890227511639776 AGE-RAGE signaling pathway in diabetic complications: TGFB1 hsa04071__57 0.86682967823762 DOWN -0.168474065774937 0.89101365722565 Sphingolipid signaling pathway: BAX hsa05217__10 0.874267953336074 UP 0.159026921899707 0.898168116084463 Basal cell carcinoma: PTCH1* hsa04920__26 0.87550876521816 UP 0.157452397920502 0.898951349642035 Adipocytokine signaling pathway: NPY hsa03320__53 0.876749883212742 UP 0.155877873941297 0.899242920609576 PPAR signaling pathway: ADIPOQ hsa04115__9 0.876749883212742 UP 0.155877873941297 0.899242920609576 p53 signaling pathway: RPRM hsa05221__35 0.877991304317697 UP 0.154303349962092 0.900024910427143 Acute myeloid leukemia: EIF4EBP1 hsa04350__41 0.881717356240151 UP 0.149579778024477 0.90335164251649 TGF-beta signaling pathway: SMAD4*** hsa04152__44 0.885446027867328 UP 0.144856206086862 0.905690302864839 AMPK signaling pathway: SLC2A4 hsa04360__82 0.885446027867328 DOWN -0.144856206086862 0.905690302864839 Axon guidance: ILK hsa04621__28 0.885446027867328 UP 0.144856206086862 0.905690302864839 NOD-like receptor signaling pathway: CASP8 hsa04520__64 0.889177237789064 DOWN -0.140132634149247 0.90901198574845 Adherens junction: CTNND1** hsa04668__102 0.895401340000113 UP 0.132260014253222 0.914877171212731 TNF signaling pathway: AKT3 hsa04971__56 0.897892806861575 UP 0.129110966294812 0.916924230485272 Gastric acid secretion: CAMK2A hsa04630__36 0.917858747277214 DOWN -0.103918582627531 0.936804229295972 Jak-STAT signaling pathway: GFAP hsa04723__46 0.93286797482341 UP 0.0850242948770711 0.951606365197171 Retrograde endocannabinoid signaling: ADCY1 hsa04620__48 0.934119896364454 DOWN -0.083449770897866 0.952366405463271 Toll-like receptor signaling pathway: CD80 hsa05160__85 0.935371980858793 UP 0.081875246918661 0.953125787436915 Hepatitis C: BAD hsa04210__58 0.940381886686159 UP 0.0755771510018409 0.957711417389318 Apoptosis: BID* hsa04360__131 0.941634739674626 UP 0.0740026270226359 0.958467863406621 Axon guidance: RAC1**** hsa05133__30 0.945394152897042 UP 0.0692790550850209 0.961773477690061 Pertussis: NOS2 hsa04530__6 11 45 0.960443134633565 DOWN -0.0503847673345606 0.976554464272981 Tight junction: CLDN24 TJP1 TJP2 hsa04270__24 0.964207794036016 DOWN -0.0456611953969456 0.979322402699283 Vascular smooth muscle contraction: ACTA2 hsa05032__13 0.964207794036016 DOWN -0.0456611953969456 0.979322402699283 Morphine addiction: PRKACA hsa05120__53 0.978017735104272 UP 0.0283414316256904 0.992812168698502 Epithelial cell signaling in Helicobacter pylori infection: GIT1 hsa04722__73 77 0.983041384007931 UP 0.0220433357088703 0.997372980859018 Neurotrophin signaling pathway: NGFRAP1 YWHAE hsa04911__24 0.984297409104441 DOWN -0.0204688117296653 0.998108381925119 Insulin secretion: INS hsa05205__91 0.985553473124599 DOWN -0.0188942877504602 0.998843029126819 Proteoglycans in cancer: RAC1* hsa05220__6 0.994346749619768 DOWN -0.0078726198960251 1 Chronic myeloid leukemia: TP53 hsa05221__41 0.996859287176596 UP 0.00472357193761506 1 Acute myeloid leukemia: MAPK1 hsa04726__39 0.999371855878075 DOWN -0.00157452397920502 1 Serotonergic synapse: CACNA1C hsa05166__114 112 113 0.999371855878075 UP 0.00157452397920502 1 HTLV-I infection: DLG1 CTNNB1 APC2 hsa04152__33 1 0 0 1 AMPK signaling pathway: CPT1C hsa04152__41 1 0 0 1 AMPK signaling pathway: FBP1 hsa04211__2 1 0 0 1 Longevity regulating pathway - mammal: RPS6KB1 hsa04911__41 1 0 0 1 Insulin secretion: ABCC8 hsa04911__35 1 0 0 1 Insulin secretion: TRPM4 hsa04922__67 1 0 0 1 Glucagon signaling pathway: FBP1 hsa04922__60 1 0 0 1 Glucagon signaling pathway: CPT1C* hsa04924__34 1 0 0 1 Renin secretion: REN hsa04924__47 1 0 0 1 Renin secretion: KCNMA1 hsa04931__151 1 0 0 1 Insulin resistance: CPT1A hsa04931__29 1 0 0 1 Insulin resistance: CPT1B hsa04960__15 1 0 0 1 Aldosterone-regulated sodium reabsorption: C00762 hsa05030__13 1 0 0 1 Cocaine addiction: SLC6A3 hsa05031__15 1 0 0 1 Amphetamine addiction: MAOA hsa05031__77 1 0 0 1 Amphetamine addiction: MAOA* hsa05034__7 1 0 0 1 Alcoholism: GRIN3A hsa05034__75 1 0 0 1 Alcoholism: SLC29A1 hsa05140__37 1 0 0 1 Leishmaniasis: ELK1 hsa05140__55 1 0 0 1 Leishmaniasis: JUN hsa05140__41 57 1 0 0 1 Leishmaniasis: NOS2 CYBA hsa05211__12 1 0 0 1 Renal cell carcinoma: EGLN2