p.value	UP.DOWN	statistic	FDRp.value	path.name
hsa04211__43 59 60 61	4.85801161040006e-16	UP	8.11564146347264	1.26839169468749e-13	Longevity regulating pathway - mammal: ULK3 RB1CC1 ATG13 ATG101
hsa04530__11 24 23	4.86019463720993e-16	DOWN	-8.11564146347264	1.26839169468749e-13	Tight junction: TJP1 YBX3 CDK4
hsa05200__168	4.86019463720993e-16	UP	8.11564146347264	1.26839169468749e-13	Pathways in cancer: E2F1
hsa04114__80	5.45364965062026e-16	UP	8.10163932154119	1.26839169468749e-13	Oocyte meiosis: CDC25C*
hsa04110__43 83 84 85	5.77660321580904e-16	DOWN	-8.09463825057546	1.26839169468749e-13	Cell cycle: SMC1B SMC3 STAG1 RAD21
hsa05166__64	6.9419977147706e-16	UP	8.07223482348512	1.26839169468749e-13	HTLV-I infection: CCNB2
hsa04750__8	7.26458938222442e-16	DOWN	-8.06663396671254	1.26839169468749e-13	Inflammatory mediator regulation of TRP channels: ASIC2
hsa04115__38	7.35159579582138e-16	UP	8.0652337525194	1.26839169468749e-13	p53 signaling pathway: GTSE1
hsa04115__11 12	8.05700097170367e-16	UP	8.05403203897423	1.26839169468749e-13	p53 signaling pathway: CDK2 CCNE1
hsa05166__65	8.14973735854667e-16	UP	8.05263182478108	1.26839169468749e-13	HTLV-I infection: PTTG2
hsa05212__34	9.13691142239273e-16	UP	8.03862968284963	1.26839169468749e-13	Pancreatic cancer: E2F1
hsa04925__18	9.45539741080643e-16	DOWN	-8.03442904027019	1.26839169468749e-13	Aldosterone synthesis and secretion: PDE2A
hsa04110__59 15 16 17 18 19 20	9.78481468436472e-16	UP	8.03022839769075	1.26839169468749e-13	Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
hsa05210__21	1.0125532421667e-15	UP	8.02602775511131	1.26839169468749e-13	Colorectal cancer: BIRC5
hsa05214__35	1.0125532421667e-15	UP	8.02602775511131	1.26839169468749e-13	Glioma: E2F1
hsa05020__52	1.257155843871e-15	DOWN	-7.99942368544155	1.47637239414601e-13	Prion diseases: FYN
hsa05200__189	1.36123695148001e-15	UP	7.98962218608953	1.50456719519467e-13	Pathways in cancer: BIRC5
hsa04270__48	1.76663942683767e-15	DOWN	-7.95741725964717	1.7899644050601e-13	Vascular smooth muscle contraction: KCNMB2*
hsa04923__16	1.84838326058041e-15	DOWN	-7.95181640287459	1.7899644050601e-13	Regulation of lipolysis in adipocytes: PLIN1
hsa04110__60 10 11 12 13 14 9	1.97803064164953e-15	DOWN	-7.94341511771572	1.7899644050601e-13	Cell cycle: CDC6 ORC3 ORC5 ORC4 ORC2 ORC1 ORC6
hsa04020__42	2.00049241651208e-15	DOWN	-7.94201490352257	1.7899644050601e-13	Calcium signaling pathway: MYLK4
hsa04923__66	2.18946424335325e-15	DOWN	-7.93081318997741	1.87000150602761e-13	Regulation of lipolysis in adipocytes: LIPE
hsa04910__17	2.34262798029844e-15	DOWN	-7.92241190481853	1.91382520651338e-13	Insulin signaling pathway: C00031
hsa04114__59	2.65131646198579e-15	UP	7.90700954869393	2.06106675910139e-13	Oocyte meiosis: REC8*
hsa05205__284	2.74223890247657e-15	DOWN	-7.90280890611449	2.06106675910139e-13	Proteoglycans in cancer: PRKCA*
hsa05020__49	2.93339179725684e-15	UP	7.89440762095562	2.1019121526259e-13	Prion diseases: BAX
hsa05010__61	3.17302979141734e-15	UP	7.8846061216036	2.1019121526259e-13	Alzheimer's disease: GAPDH
hsa04914__30	3.2815095216823e-15	UP	7.88040547902416	2.1019121526259e-13	Progesterone-mediated oocyte maturation: CDK1*
hsa04210__75	3.28153921220498e-15	UP	7.88040547902416	2.1019121526259e-13	Apoptosis: BAK1*
hsa04728__44	3.35590019046178e-15	DOWN	-7.87760505063787	2.1019121526259e-13	Dopaminergic synapse: FOS
hsa05205__270	3.62946523987315e-15	DOWN	-7.86780355128585	2.1999242534586e-13	Proteoglycans in cancer: MAPK1****
hsa05031__98	3.75332255683654e-15	DOWN	-7.86360290870641	2.20390408884246e-13	Amphetamine addiction: FOS
hsa04270__10 3 71	3.96906176128709e-15	DOWN	-7.85660183774068	2.2599597119571e-13	Vascular smooth muscle contraction: ACTA2 MYL9 MYH11
hsa04066__88	4.43781177797795e-15	DOWN	-7.84259969580923	2.30457165222518e-13	HIF-1 signaling pathway: BCL2
hsa04022__65	4.53790099741017e-15	DOWN	-7.83979926742293	2.30457165222518e-13	cGMP-PKG signaling pathway: PDE2A
hsa03460__7	4.64021175288181e-15	UP	7.83699883903664	2.30457165222518e-13	Fanconi anemia pathway: FANCI
hsa05020__24	4.9059534906337e-15	DOWN	-7.82999776807091	2.30457165222518e-13	Prion diseases: PRNP*
hsa05020__26	4.9059534906337e-15	DOWN	-7.82999776807091	2.30457165222518e-13	Prion diseases: PRNP**
hsa05020__25 8	4.9059534906337e-15	DOWN	-7.82999776807091	2.30457165222518e-13	Prion diseases: PRNP PRNP*
hsa05020__10 34	4.9059534906337e-15	DOWN	-7.82999776807091	2.30457165222518e-13	Prion diseases: PRNP PRNP***
hsa04010__58	5.54471563835338e-15	UP	7.81459541194631	2.53302468415612e-13	MAPK signaling pathway: CDC25B
hsa05166__120	5.73266944986301e-15	UP	7.81039476936687	2.53302468415612e-13	HTLV-I infection: E2F1
hsa04010__65	5.79670364123007e-15	UP	7.80899455517373	2.53302468415612e-13	MAPK signaling pathway: ELK4
hsa04914__11	6.12758719953651e-15	UP	7.801993484208	2.61675826089298e-13	Progesterone-mediated oocyte maturation: CDK1
hsa04919__100	6.77067218768904e-15	DOWN	-7.78939155646969	2.79829207367938e-13	Thyroid hormone signaling pathway: CTNNB1*
hsa03460__48	6.92235999978746e-15	UP	7.7865911280834	2.79829207367938e-13	Fanconi anemia pathway: RAD51
hsa04919__32	6.99945329765466e-15	DOWN	-7.78519091389025	2.79829207367938e-13	Thyroid hormone signaling pathway: PLN
hsa04022__57	7.31636712260438e-15	DOWN	-7.77959005711767	2.80560282109666e-13	cGMP-PKG signaling pathway: C00144
hsa05221__35	7.31636712260438e-15	UP	7.77959005711767	2.80560282109666e-13	Acute myeloid leukemia: EIF4EBP1
hsa04530__5 15	7.56328055913366e-15	DOWN	-7.77538941453823	2.84228083412243e-13	Tight junction: IGSF5 MPDZ
hsa04970__45	8.44694894111252e-15	DOWN	-7.76138727260677	3.11212099222558e-13	Salivary secretion: KCNMA1
hsa04726__45	9.02517891995134e-15	DOWN	-7.7529859874479	3.2612136904978e-13	Serotonergic synapse: TRPC1
hsa04919__49	9.53667646688037e-15	DOWN	-7.74598491648217	3.31844751674233e-13	Thyroid hormone signaling pathway: ACTB
hsa04152__62	9.53678370963735e-15	UP	7.74598491648217	3.31844751674233e-13	AMPK signaling pathway: EIF4EBP1
hsa04022__37 38	1.00767769721259e-14	DOWN	-7.73898384551644	3.44259344193173e-13	cGMP-PKG signaling pathway: ATP2A1 PLN
hsa04970__32	1.03011013999037e-14	DOWN	-7.73618341713015	3.45638741614625e-13	Salivary secretion: RYR3
hsa04930__3	1.06468318966136e-14	DOWN	-7.73198277455071	3.50971879539245e-13	Type II diabetes mellitus: SLC2A4
hsa04022__44	1.10039747558698e-14	DOWN	-7.72778213197128	3.56490837349643e-13	cGMP-PKG signaling pathway: BAD
hsa04919__21 53	1.17539901751279e-14	DOWN	-7.7193808468124	3.74334704051954e-13	Thyroid hormone signaling pathway: THRA C02465
hsa04550__34	1.24172487375645e-14	DOWN	-7.71237977584667	3.88866839631395e-13	Signaling pathways regulating pluripotency of stem cells: MAPK1*
hsa04152__56	1.34080693409937e-14	UP	7.70257827649465	4.06351004705278e-13	AMPK signaling pathway: FASN
hsa04713__60	1.34080693409937e-14	DOWN	-7.70257827649465	4.06351004705278e-13	Circadian entrainment: PER1
hsa04010__61	1.44765819140758e-14	UP	7.69277677714263	4.31769800262674e-13	MAPK signaling pathway: ATF4
hsa04015__100 101 48	1.56287677252818e-14	DOWN	-7.68297527779061	4.58850852434447e-13	Rap1 signaling pathway: PRKCI PARD6A PARD3
hsa04152__44	1.66878159991107e-14	DOWN	-7.67457399263174	4.7130522230478e-13	AMPK signaling pathway: SLC2A4
hsa05031__10	1.68710597197127e-14	DOWN	-7.67317377843859	4.7130522230478e-13	Amphetamine addiction: CACNA1C
hsa05031__53	1.68710597197127e-14	DOWN	-7.67317377843859	4.7130522230478e-13	Amphetamine addiction: CACNA1C*
hsa04010__79	1.70562826592469e-14	UP	7.67177356424545	4.7130522230478e-13	MAPK signaling pathway: HSPB1
hsa04015__30	1.84100541280734e-14	DOWN	-7.66197206489343	5.01340459516665e-13	Rap1 signaling pathway: ITGAL
hsa04270__28	2.09808716598665e-14	DOWN	-7.64516949457568	5.63186540698415e-13	Vascular smooth muscle contraction: KCNMB2
hsa04010__64	2.28876977816832e-14	UP	7.63396778103051	6.05718086363138e-13	MAPK signaling pathway: DDIT3
hsa04022__50	2.44287274196877e-14	DOWN	-7.62556649587164	6.37521928077684e-13	cGMP-PKG signaling pathway: ATP2B1
hsa05020__48	2.52370678358534e-14	DOWN	-7.6213658532922	6.49595211829705e-13	Prion diseases: SOD1
hsa04310__35	2.5790518416115e-14	DOWN	-7.61856542490591	6.54870055457838e-13	Wnt signaling pathway: JUN
hsa04726__64	2.69334736251285e-14	UP	7.61296456813333	6.73149511238749e-13	Serotonergic synapse: CASP3
hsa04713__61	2.722690944872e-14	DOWN	-7.61156435394018	6.73149511238749e-13	Circadian entrainment: FOS
hsa05223__28	2.84324236026903e-14	UP	7.6059634971676	6.9382498635656e-13	Non-small cell lung cancer: RB1
hsa04022__45	3.00133478129975e-14	DOWN	-7.59896242620187	7.13861778995219e-13	cGMP-PKG signaling pathway: CREB3
hsa04931__46	3.00133478129975e-14	DOWN	-7.59896242620187	7.13861778995219e-13	Insulin resistance: PIK3R5*
hsa04066__89	3.16806475197424e-14	DOWN	-7.59196135523614	7.34912798636988e-13	HIF-1 signaling pathway: CDKN1A
hsa04921__58	3.16806475197424e-14	DOWN	-7.59196135523614	7.34912798636988e-13	Oxytocin signaling pathway: MEF2C
hsa04115__43 57	3.30797829510126e-14	UP	7.58636049846356	7.57009612836424e-13	p53 signaling pathway: CDK1 CCNB3
hsa04068__39	3.34389557559464e-14	UP	7.58496028427041	7.57009612836424e-13	FoxO signaling pathway: CCNB3
hsa05218__21	3.52931492810966e-14	UP	7.57795921330468	7.80186205872711e-13	Melanoma: RB1
hsa05220__40	3.52931492810966e-14	UP	7.57795921330468	7.80186205872711e-13	Chronic myeloid leukemia: RB1
hsa04921__53	3.60628154657866e-14	DOWN	-7.57515878491839	7.87930584421082e-13	Oxytocin signaling pathway: RGS2
hsa04015__67	3.72483611418736e-14	DOWN	-7.57095814233895	7.95337165745234e-13	Rap1 signaling pathway: AKT3
hsa05169__45	3.72483611418736e-14	DOWN	-7.57095814233895	7.95337165745234e-13	Epstein-Barr virus infection: RB1
hsa04022__43	4.01657085837598e-14	DOWN	-7.56115664298693	8.47992881223423e-13	cGMP-PKG signaling pathway: MAPK1
hsa04310__36	4.14837333220293e-14	DOWN	-7.5569560004075	8.66088165689923e-13	Wnt signaling pathway: MYC
hsa04540__14 31	4.37755632729357e-14	DOWN	-7.54995492944177	9.03893224064243e-13	Gap junction: GJA1 TJP1
hsa04012__22	4.71945689296217e-14	UP	7.54015343008975	9.63897771943034e-13	ErbB signaling pathway: EIF4EBP1
hsa04015__17	4.92647867979769e-14	DOWN	-7.53455257331716	9.95360584875254e-13	Rap1 signaling pathway: ACTB
hsa04066__44	5.14242286154382e-14	DOWN	-7.52895171654458	1.0279375060469e-12	HIF-1 signaling pathway: GAPDH
hsa04066__45	5.31046281369491e-14	DOWN	-7.52475107396514	1.03941246113883e-12	HIF-1 signaling pathway: ALDOA
hsa05231__38	5.31046281369491e-14	UP	7.52475107396514	1.03941246113883e-12	Choline metabolism in cancer: RPS6KB1
hsa05161__126	5.48389862442201e-14	DOWN	-7.52055043138571	1.05145362400908e-12	Hepatitis B: MYC*
hsa05166__62 63	5.48389862442201e-14	UP	7.52055043138571	1.05145362400908e-12	HTLV-I infection: ANAPC10 CDC20
hsa04068__72	5.66290039923651e-14	DOWN	-7.51634978880627	1.06405898501654e-12	FoxO signaling pathway: SMAD2
hsa05034__84	5.66290039923651e-14	DOWN	-7.51634978880627	1.06405898501654e-12	Alcoholism: FOSB
hsa05012__71	5.72383469387697e-14	DOWN	-7.51494957461312	1.06485993958365e-12	Parkinson's disease: PRKACA*
hsa04022__3	5.84764350315972e-14	DOWN	-7.51214914622683	1.07722766102325e-12	cGMP-PKG signaling pathway: MYL9
hsa04728__74	6.50728233130669e-14	DOWN	-7.49814700429538	1.18710519422575e-12	Dopaminergic synapse: GRIN2A
hsa04210__74	6.64772964786879e-14	UP	7.49534657590908	1.18962704841385e-12	Apoptosis: BAX*
hsa04666__42	6.64772964786879e-14	UP	7.49534657590908	1.18962704841385e-12	Fc gamma R-mediated phagocytosis: MYO10
hsa04540__14 16	7.39590939232573e-14	DOWN	-7.48134443397763	1.29877698581122e-12	Gap junction: GJA1 GJA1
hsa04540__14 15	7.39590939232573e-14	DOWN	-7.48134443397763	1.29877698581122e-12	Gap junction: GJA1 GJA1*
hsa04072__3	8.95680887340938e-14	DOWN	-7.456140578501	1.55831887714224e-12	Phospholipase D signaling pathway: MAPK1
hsa04972__23	9.85445020089425e-14	DOWN	-7.44353865076269	1.69876256215415e-12	Pancreatic secretion: KCNMA1
hsa04740__21	1.00656253568329e-13	DOWN	-7.4407382223764	1.71939182231719e-12	Olfactory transduction: PDE1A
hsa04024__9 95	1.01728745042967e-13	DOWN	-7.43933800818326	1.7220568642859e-12	cAMP signaling pathway: ATP1B4 FXYD1
hsa04971__55	1.03907530748144e-13	DOWN	-7.43653757979696	1.74323437746216e-12	Gastric acid secretion: MYLK4
hsa04022__39	1.05014056988462e-13	DOWN	-7.43513736560382	1.74620719540991e-12	cGMP-PKG signaling pathway: KCNJ8
hsa04931__149	1.06132162111188e-13	DOWN	-7.43373715141067	1.74931870707827e-12	Insulin resistance: ACACB*
hsa04724__67	1.11900576344275e-13	DOWN	-7.42673608044494	1.82835811261645e-12	Glutamatergic synapse: PLD1
hsa04931__124	1.24377016399639e-13	DOWN	-7.41273393851349	2.01469322254244e-12	Insulin resistance: FOXO1*
hsa04015__82	1.25697404359149e-13	DOWN	-7.41133372432034	2.01867882727214e-12	Rap1 signaling pathway: ITGA2B
hsa04151__4	1.38217871384383e-13	UP	7.39873179658203	2.20094390111234e-12	PI3K-Akt signaling pathway: RPS6
hsa04261__8 38	1.8749101285193e-13	DOWN	-7.3581255849808	2.9422216243246e-12	Adrenergic signaling in cardiomyocytes: ATP2A2 PLN
hsa04014__24	1.89467172189078e-13	DOWN	-7.35672537078766	2.9422216243246e-12	Ras signaling pathway: PLD1
hsa04152__64	1.89467172189078e-13	DOWN	-7.35672537078766	2.9422216243246e-12	AMPK signaling pathway: ACACB
hsa04970__18	1.99659052108104e-13	DOWN	-7.34972429982193	3.05733194755956e-12	Salivary secretion: VAMP2
hsa04066__46	2.01761129056618e-13	DOWN	-7.34832408562878	3.05733194755956e-12	HIF-1 signaling pathway: ENO1
hsa04931__61	2.01761129056618e-13	DOWN	-7.34832408562878	3.05733194755956e-12	Insulin resistance: ACACB
hsa05161__100	2.06030718501076e-13	UP	7.34552365724249	3.09705376050817e-12	Hepatitis B: MMP9*
hsa04270__24	2.12602033527529e-13	DOWN	-7.34132301466305	3.17047000792244e-12	Vascular smooth muscle contraction: ACTA2
hsa05220__4	2.19379133355856e-13	DOWN	-7.33712237208362	3.24577473681617e-12	Chronic myeloid leukemia: PTPN11
hsa04022__48	2.21684983671198e-13	DOWN	-7.33572215789047	3.25426628373579e-12	cGMP-PKG signaling pathway: SLC8A2
hsa04012__29	2.24014638487495e-13	DOWN	-7.33432194369733	3.26297291254266e-12	ErbB signaling pathway: STAT5A*
hsa04919__40	2.31148853252456e-13	DOWN	-7.33012130111789	3.34098996354896e-12	Thyroid hormone signaling pathway: RCAN2
hsa05166__34 35 36	2.36026124682622e-13	DOWN	-7.3273208727316	3.3854434219744e-12	HTLV-I infection: MYC TRRAP KAT5
hsa04210__50	2.43538283518829e-13	DOWN	-7.32312023015216	3.44066492279609e-12	Apoptosis: SPTA1
hsa04664__23	2.43538283518829e-13	DOWN	-7.32312023015216	3.44066492279609e-12	Fc epsilon RI signaling pathway: AKT3
hsa04925__3	2.46093322000486e-13	DOWN	-7.32172001595901	3.45081605999189e-12	Aldosterone synthesis and secretion: ITPR1
hsa04022__66	2.75996165053946e-13	UP	7.30631765983441	3.79728578982948e-12	cGMP-PKG signaling pathway: PDE3A
hsa05145__35	2.75996165053946e-13	UP	7.30631765983441	3.79728578982948e-12	Toxoplasmosis: CASP3
hsa04270__65	2.78879379531665e-13	DOWN	-7.30491744564126	3.79728578982948e-12	Vascular smooth muscle contraction: NPR2
hsa04152__61	2.7888527886986e-13	UP	7.30491744564126	3.79728578982948e-12	AMPK signaling pathway: RPS6KB1
hsa05200__227	2.8180409262099e-13	DOWN	-7.30351723144812	3.80942366931539e-12	Pathways in cancer: FOXO1
hsa04520__1 13	3.19258503790481e-13	DOWN	-7.28671466113037	4.2849052044451e-12	Adherens junction: SMAD4 SMAD2
hsa04970__28	3.28294500228574e-13	UP	7.28251401855093	4.3749316732588e-12	Salivary secretion: AQP5
hsa04933__19	3.43321234875551e-13	DOWN	-7.27691316177835	4.5429619741631e-12	AGE-RAGE signaling pathway in diabetic complications: TGFBR2
hsa04620__21	3.69162727521269e-13	UP	7.26711166242633	4.85074660847877e-12	Toll-like receptor signaling pathway: IFNA1
hsa04924__31	3.72996291061383e-13	DOWN	-7.26571144823318	4.8670835479468e-12	Renin secretion: C02135
hsa04213__60	3.76890527319002e-13	DOWN	-7.26431123404004	4.88398138505107e-12	Longevity regulating pathway - multiple species: CAT
hsa04630__31	4.22319321247223e-13	UP	7.24890887791544	5.43519181248994e-12	Jak-STAT signaling pathway: BCL2L1
hsa04924__49	4.3561529559835e-13	DOWN	-7.244708235336	5.56817102332857e-12	Renin secretion: PDE1A
hsa03460__28	4.49322077686749e-13	UP	7.24050759275656	5.70456881063108e-12	Fanconi anemia pathway: RAD51C
hsa04068__58	4.63452110969518e-13	DOWN	-7.23630695017712	5.84447326517936e-12	FoxO signaling pathway: KLF2
hsa04066__63	4.73113584376919e-13	DOWN	-7.23350652179083	5.88728758307438e-12	HIF-1 signaling pathway: TIMP1*
hsa04066__57	4.73113584376919e-13	DOWN	-7.23350652179083	5.88728758307438e-12	HIF-1 signaling pathway: TIMP1
hsa05016__52	5.0851175319104e-13	UP	7.22370502243881	6.28614200161818e-12	Huntington's disease: CASP3
hsa04919__101	5.13776409111342e-13	DOWN	-7.22230480824567	6.30971158640661e-12	Thyroid hormone signaling pathway: NOTCH1
hsa04620__20	5.24466769691739e-13	UP	7.21950437985938	6.39917571591414e-12	Toll-like receptor signaling pathway: IFNB1*
hsa04152__57	5.2989354604721e-13	UP	7.21810416566623	6.42367724530779e-12	AMPK signaling pathway: ACACA*
hsa05133__73	5.40913009466229e-13	DOWN	-7.21530373727994	6.515227851199e-12	Pertussis: FOS
hsa04022__49	5.69455478766645e-13	DOWN	-7.20830266631421	6.79913072083884e-12	cGMP-PKG signaling pathway: ATP1B4
hsa04310__33	5.75338895483435e-13	DOWN	-7.20690245212106	6.79913072083884e-12	Wnt signaling pathway: CCND1
hsa04340__13	5.75338895483435e-13	DOWN	-7.20690245212106	6.79913072083884e-12	Hedgehog signaling pathway: GLI1*
hsa04722__53	5.9334951774977e-13	DOWN	-7.20270180954163	6.96814839907387e-12	Neurotrophin signaling pathway: JUN
hsa05014__5	6.11913341000776e-13	UP	7.19850116696219	7.14152278099664e-12	Amyotrophic lateral sclerosis (ALS): TOMM40
hsa04020__8	6.2460476124562e-13	DOWN	-7.1957007385759	7.24464411346e-12	Calcium signaling pathway: PDE1A
hsa04066__48	6.31047019325866e-13	DOWN	-7.19430052438275	7.27446226572579e-12	HIF-1 signaling pathway: PFKFB3
hsa04152__78	6.44127837024397e-13	UP	7.19150009599646	7.3221108014462e-12	AMPK signaling pathway: CCNA2
hsa04022__46	6.50767697627203e-13	DOWN	-7.19009988180332	7.3221108014462e-12	cGMP-PKG signaling pathway: VASP
hsa04024__113	6.50767697627203e-13	DOWN	-7.19009988180332	7.3221108014462e-12	cAMP signaling pathway: PTCH1
hsa04921__46	6.50767697627203e-13	DOWN	-7.19009988180332	7.3221108014462e-12	Oxytocin signaling pathway: C00942*
hsa04530__11 13	6.64249622354675e-13	DOWN	-7.18729945341702	7.42931571669306e-12	Tight junction: TJP1 EPB41
hsa04550__36	6.78005626898506e-13	DOWN	-7.18449902503073	7.53829924817925e-12	Signaling pathways regulating pluripotency of stem cells: AKT3*
hsa04724__68	6.99165510169102e-13	DOWN	-7.1802983824513	7.72783525651613e-12	Glutamatergic synapse: MAPK1
hsa04340__52	7.06361829250564e-13	DOWN	-7.17889816825815	7.76171857989363e-12	Hedgehog signaling pathway: BCL2*
hsa04340__20 22	7.35881290175819e-13	DOWN	-7.17329731148557	8.03907525721141e-12	Hedgehog signaling pathway: GLI1 SUFU*
hsa04810__35 81 80	8.66554862005343e-13	DOWN	-7.15089388439524	9.41188777865919e-12	Regulation of actin cytoskeleton: MYL12B MYH9 ACTB
hsa04015__14	9.02629820933872e-13	DOWN	-7.14529302762265	9.74736456054451e-12	Rap1 signaling pathway: MAPK14
hsa04210__84	9.49801550926095e-13	DOWN	-7.13829195665692	1.01981549382293e-11	Apoptosis: FAS**
hsa04911__25	9.6934036493781e-13	DOWN	-7.13549152827063	1.03488099188531e-11	Insulin secretion: PRKCA
hsa04071__65	9.9939036845539e-13	UP	7.13129088569119	1.05391935998368e-11	Sphingolipid signaling pathway: BAX*
hsa04152__58	9.9939036845539e-13	UP	7.13129088569119	1.05391935998368e-11	AMPK signaling pathway: SCD
hsa04913__47	1.00960875357671e-12	DOWN	-7.12989067149805	1.05391935998368e-11	Ovarian steroidogenesis: INSR
hsa04913__51	1.00960875357671e-12	DOWN	-7.12989067149805	1.05391935998368e-11	Ovarian steroidogenesis: INSR*
hsa04668__40	1.04088303924578e-12	DOWN	-7.12569002891861	1.08056311090763e-11	TNF signaling pathway: JUN
hsa04152__82	1.17576886136454e-12	UP	7.10888745860086	1.20725119699671e-11	AMPK signaling pathway: HMGCR
hsa04728__68	1.17576886136454e-12	DOWN	-7.10888745860086	1.20725119699671e-11	Dopaminergic synapse: CACNA1C
hsa04630__24	1.22443348548623e-12	UP	7.10328660182828	1.25038615175469e-11	Jak-STAT signaling pathway: MCL1
hsa05205__415	1.2369052080956e-12	DOWN	-7.10188638763513	1.25629453297926e-11	Proteoglycans in cancer: MAPK1******
hsa04924__23	1.34126957020276e-12	DOWN	-7.09068467408997	1.34055612894202e-11	Renin secretion: ITPR1
hsa05200__199	1.34126957020276e-12	DOWN	-7.09068467408997	1.34055612894202e-11	Pathways in cancer: BCL2L1**
hsa05220__3	1.34126957020276e-12	DOWN	-7.09068467408997	1.34055612894202e-11	Chronic myeloid leukemia: BCL2L1
hsa05020__59	1.35490786910328e-12	DOWN	-7.08928445989682	1.3470221619286e-11	Prion diseases: CCL5
hsa04261__39	1.46902506727595e-12	DOWN	-7.07808274635166	1.45278847442711e-11	Adrenergic signaling in cardiomyocytes: SCN1B
hsa04390__76	1.52956824098563e-12	DOWN	-7.07248188957907	1.49690558583958e-11	Hippo signaling pathway: MYC
hsa04660__34	1.52956824098563e-12	DOWN	-7.07248188957907	1.49690558583958e-11	T cell receptor signaling pathway: FOS
hsa05205__30	1.54508252201114e-12	DOWN	-7.07108167538593	1.50425391650722e-11	Proteoglycans in cancer: FLNA
hsa05215__13	1.60869831397068e-12	DOWN	-7.06548081861335	1.55811553193346e-11	Prostate cancer: BCL2
hsa05168__122	1.65808970129334e-12	UP	7.06128017603391	1.59771823011804e-11	Herpes simplex infection: CASP3
hsa04919__104	1.70896792428586e-12	DOWN	-7.05707953345447	1.63820831368682e-11	Thyroid hormone signaling pathway: MYC
hsa05110__12	1.72626527998931e-12	UP	7.05567931926133	1.63820831368682e-11	Vibrio cholerae infection: C00080
hsa05120__35	1.72626527998931e-12	UP	7.05567931926133	1.63820831368682e-11	Epithelial cell signaling in Helicobacter pylori infection: C00080
hsa05160__7	1.77919435363153e-12	UP	7.05147867668189	1.6799528595345e-11	Hepatitis C: IRF3
hsa04213__71	1.87096829872953e-12	DOWN	-7.04447760571616	1.75777471665639e-11	Longevity regulating pathway - multiple species: SIRT1**
hsa05110__51	1.90895829957941e-12	UP	7.04167717732987	1.7845436044327e-11	Vibrio cholerae infection: PDIA4
hsa04151__103	2.08952482455226e-12	DOWN	-7.02907524959156	1.94367185412559e-11	PI3K-Akt signaling pathway: BCL2*
hsa04010__63	2.17505442497507e-12	UP	7.02347439281897	2.01326466232914e-11	MAPK signaling pathway: MAX
hsa05132__13	2.19696777507557e-12	DOWN	-7.02207417862583	2.02357963204265e-11	Salmonella infection: FOS
hsa05164__20	2.42836122575683e-12	DOWN	-7.00807203669437	2.22580036253516e-11	Influenza A: ATF2
hsa04211__29	2.55285849496979e-12	DOWN	-7.00107096572864	2.31730488504746e-11	Longevity regulating pathway - mammal: EIF4E
hsa05030__69	2.55285849496979e-12	DOWN	-7.00107096572864	2.31730488504746e-11	Cocaine addiction: PRKACA**
hsa05030__37	2.6569443486929e-12	DOWN	-6.99547010895606	2.40019155345864e-11	Cocaine addiction: PRKACA
hsa05215__25	2.76518886172638e-12	DOWN	-6.98986925218348	2.48602386181046e-11	Prostate cancer: FOXO1
hsa04919__31	2.84919896387393e-12	DOWN	-6.98566860960404	2.54935469196148e-11	Thyroid hormone signaling pathway: ATP2A2
hsa05161__213	2.87775465847836e-12	UP	6.98426839541089	2.5627018972895e-11	Hepatitis B: E2F1
hsa04151__25	2.96511617617069e-12	DOWN	-6.98006775283146	2.62804400708713e-11	PI3K-Akt signaling pathway: CDKN1B
hsa04010__68	2.99481057904743e-12	UP	6.97866753863831	2.64190097560099e-11	MAPK signaling pathway: ATF2
hsa05162__13	3.11653191105502e-12	UP	6.97306668186573	2.72370393528948e-11	Measles: IRF7
hsa05231__18	3.11653191105502e-12	UP	6.97306668186573	2.72370393528948e-11	Choline metabolism in cancer: CHKA
hsa04024__24	3.14771238936922e-12	DOWN	-6.97166646767258	2.73821832390035e-11	cAMP signaling pathway: PLN
hsa04910__26	3.27552219588232e-12	UP	6.9660656109	2.8362701410428e-11	Insulin signaling pathway: RPS6
hsa04530__30	3.30826151647566e-12	UP	6.96466539670685	2.85147861901732e-11	Tight junction: AKT3
hsa04724__36	3.34132164108577e-12	DOWN	-6.96326518251371	2.8668234536987e-11	Glutamatergic synapse: TRPC1
hsa04933__12	3.40841664332139e-12	DOWN	-6.96046475412742	2.91109766945495e-11	AGE-RAGE signaling pathway in diabetic complications: EGR1
hsa04211__38	3.69025877939354e-12	UP	6.94926304058225	3.12342173264886e-11	Longevity regulating pathway - mammal: BAX
hsa04933__21	3.69025877939354e-12	DOWN	-6.94926304058225	3.12342173264886e-11	AGE-RAGE signaling pathway in diabetic complications: SMAD4
hsa04071__59 60	4.07485152144607e-12	DOWN	-6.93526089865079	3.43347354654582e-11	Sphingolipid signaling pathway: TP53 BCL2
hsa04623__9	4.15635614493489e-12	UP	6.9324604702645	3.47101919837007e-11	Cytosolic DNA-sensing pathway: IKBKE
hsa05012__70	4.15635614493489e-12	DOWN	-6.9324604702645	3.47101919837007e-11	Parkinson's disease: PRKACA
hsa05031__97	4.23945838305596e-12	DOWN	-6.92966004187821	3.52475323086821e-11	Amphetamine addiction: ARC
hsa04919__88	4.28161816376907e-12	DOWN	-6.92825982768506	3.52857917970267e-11	Thyroid hormone signaling pathway: FOXO1
hsa04922__17	4.28161816376907e-12	DOWN	-6.92825982768506	3.52857917970267e-11	Glucagon signaling pathway: PKM
hsa04960__4	4.49866018145891e-12	DOWN	-6.92125875671934	3.69125872531061e-11	Aldosterone-regulated sodium reabsorption: ATP1B4
hsa05200__194	4.54334517315872e-12	DOWN	-6.91985854252619	3.71171546972401e-11	Pathways in cancer: BCL2
hsa04923__52 53	4.58846519049194e-12	UP	6.91845832833304	3.73234895798024e-11	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5*
hsa05217__4	4.72647704794506e-12	DOWN	-6.91425768575361	3.82803895391757e-11	Basal cell carcinoma: PTCH1
hsa05211__48	5.11471084958241e-12	DOWN	-6.90305597220844	4.12469600273191e-11	Renal cell carcinoma: JUN
hsa04022__71	5.81323366511641e-12	UP	6.88485318769755	4.66797694733066e-11	cGMP-PKG signaling pathway: PPIF
hsa04520__69	6.04638850180371e-12	DOWN	-6.87925233092496	4.8345378701656e-11	Adherens junction: IQGAP1**
hsa04115__58	6.35075103197196e-12	UP	6.87225125995923	5.05638185977768e-11	p53 signaling pathway: CASP3
hsa04960__3	6.41340090856823e-12	DOWN	-6.87085104576609	5.08471742919819e-11	Aldosterone-regulated sodium reabsorption: SCNN1A
hsa05020__46	7.28509617927737e-12	DOWN	-6.85264826125519	5.75155282389167e-11	Prion diseases: PRKACA
hsa04022__51	7.57594309541993e-12	DOWN	-6.84704740448261	5.95614940430713e-11	cGMP-PKG signaling pathway: GTF2I
hsa04151__26	7.65041455826613e-12	DOWN	-6.84564719028947	5.98963706457586e-11	PI3K-Akt signaling pathway: RBL2
hsa04723__9	8.35375567844528e-12	DOWN	-6.83304526255115	6.45955017275666e-11	Retrograde endocannabinoid signaling: PRKCA
hsa04725__20	8.35375567844528e-12	DOWN	-6.83304526255115	6.45955017275666e-11	Cholinergic synapse: PRKCA
hsa04726__18	8.35375567844528e-12	DOWN	-6.83304526255115	6.45955017275666e-11	Serotonergic synapse: PRKCA
hsa05215__39	8.51845354594248e-12	UP	6.83024483416486	6.55990746427292e-11	Prostate cancer: RB1
hsa04911__4	8.94424358515342e-12	DOWN	-6.82324376319913	6.80414319696489e-11	Insulin secretion: CACNA1C
hsa05020__62	8.94424358515342e-12	DOWN	-6.82324376319913	6.80414319696489e-11	Prion diseases: NOTCH1
hsa05161__30	8.94424358515342e-12	DOWN	-6.82324376319913	6.80414319696489e-11	Hepatitis B: MYC
hsa04211__56	9.48277590032024e-12	DOWN	-6.81484247804026	7.18473222447651e-11	Longevity regulating pathway - mammal: CAT
hsa04010__66	9.66924940375142e-12	UP	6.81204204965397	7.26740785185957e-11	MAPK signaling pathway: TP53
hsa04970__27	9.66924940375142e-12	DOWN	-6.81204204965397	7.26740785185957e-11	Salivary secretion: PRKCA
hsa04066__47	9.76382860438228e-12	DOWN	-6.81064183546082	7.30925655284235e-11	HIF-1 signaling pathway: PGK1
hsa04390__94	1.06568543366868e-11	DOWN	-6.79803990772251	7.94612273755337e-11	Hippo signaling pathway: GLI2
hsa04310__32	1.26894813813626e-11	DOWN	-6.77283605224589	9.42432233817401e-11	Wnt signaling pathway: PPARD
hsa04919__99	1.31903061427437e-11	DOWN	-6.76723519547331	9.75771072528162e-11	Thyroid hormone signaling pathway: WNT4
hsa05030__76	1.34479277472783e-11	DOWN	-6.76443476708701	9.90927695573957e-11	Cocaine addiction: PDYN
hsa03460__25 40	1.35785801596604e-11	UP	6.76303455289387	9.92768564980616e-11	Fanconi anemia pathway: MLH1 PMS2
hsa05161__125	1.35785801596604e-11	DOWN	-6.76303455289387	9.92768564980616e-11	Hepatitis B: CDKN1A
hsa04110__10 11 12 13 14 9 15 16 17 18 19 20	1.45286056604162e-11	UP	6.75323305354185	1.05811046650861e-10	Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2
hsa04911__56	1.49554117238684e-11	DOWN	-6.74903241096241	1.08498913626057e-10	Insulin secretion: CAMK2A*
hsa03460__27	1.52467457312054e-11	UP	6.74623198257612	1.10187058572827e-10	Fanconi anemia pathway: BRCA1
hsa04150__31	1.8483377597416e-11	UP	6.71822769871321	1.33066155193658e-10	mTOR signaling pathway: EIF4E
hsa04152__54	2.01508921989612e-11	DOWN	-6.70562577097489	1.44517276495603e-10	AMPK signaling pathway: SLC2A4*
hsa04919__26	2.46355104362624e-11	DOWN	-6.67622127291883	1.76008076462878e-10	Thyroid hormone signaling pathway: THRB
hsa04115__9	2.71011709971257e-11	DOWN	-6.66221913098738	1.92890531453027e-10	p53 signaling pathway: RPRM
hsa04921__57	2.73606314269686e-11	DOWN	-6.66081891679423	1.94002363967072e-10	Oxytocin signaling pathway: FOS
hsa05220__15	2.7886867362258e-11	DOWN	-6.65801848840794	1.96990314938657e-10	Chronic myeloid leukemia: MYC
hsa04920__10	2.84230061122709e-11	UP	6.65521806002165	2.00025574850026e-10	Adipocytokine signaling pathway: PCK1
hsa04014__27	2.86948458126256e-11	DOWN	-6.6538178458285	2.00437231531314e-10	Ras signaling pathway: ABL1
hsa05152__51	2.86948458126256e-11	UP	6.6538178458285	2.00437231531314e-10	Tuberculosis: CASP3
hsa04064__3	2.89692297464685e-11	DOWN	-6.65241763163536	2.0160438034672e-10	NF-kappa B signaling pathway: BCL2
hsa04020__7	3.00926763277609e-11	DOWN	-6.64681677486277	2.08649958744881e-10	Calcium signaling pathway: ADCY1
hsa04666__38	3.03801346480533e-11	DOWN	-6.64541656066963	2.09868650748868e-10	Fc gamma R-mediated phagocytosis: CFL1
hsa04723__73	3.15570844475572e-11	DOWN	-6.63981570389704	2.16407889331971e-10	Retrograde endocannabinoid signaling: MAPK14*
hsa04723__68	3.15570844475572e-11	DOWN	-6.63981570389704	2.16407889331971e-10	Retrograde endocannabinoid signaling: MAPK14
hsa04390__60	3.18582253876518e-11	DOWN	-6.6384154897039	2.17678565466901e-10	Hippo signaling pathway: CTGF*
hsa04510__44	3.34066253892927e-11	DOWN	-6.63141441873817	2.27431337342322e-10	Focal adhesion: BCL2
hsa04261__36	3.50285995947174e-11	DOWN	-6.62441334777244	2.37612774868137e-10	Adrenergic signaling in cardiomyocytes: MAPK1
hsa04610__57	3.63814405882813e-11	UP	6.61881249099986	2.45901895199211e-10	Complement and coagulation cascades: PLAUR
hsa05169__93	3.67275606999212e-11	UP	6.61741227680671	2.47351564713806e-10	Epstein-Barr virus infection: PLCG1
hsa04010__54	3.70769024504907e-11	DOWN	-6.61601206261357	2.47927045211644e-10	MAPK signaling pathway: NR4A1
hsa05110__52	3.70769024504907e-11	DOWN	-6.61601206261357	2.47927045211644e-10	Vibrio cholerae infection: ADCY3
hsa04728__32	3.85070756583794e-11	DOWN	-6.61041120584098	2.56577287808847e-10	Dopaminergic synapse: CREB3
hsa05200__207	4.15312193956645e-11	DOWN	-6.59920949229582	2.75749686376161e-10	Pathways in cancer: CDK4
hsa05220__22	4.39506451425638e-11	DOWN	-6.59080820713694	2.90786134587596e-10	Chronic myeloid leukemia: CDKN1B
hsa05205__121	4.56396479401884e-11	UP	6.58520735036436	3.00901398174084e-10	Proteoglycans in cancer: PLAUR
hsa04919__11	4.69479140368755e-11	DOWN	-6.58100670778492	3.0706813623272e-10	Thyroid hormone signaling pathway: CTNNB1
hsa05030__73	4.69479140368755e-11	DOWN	-6.58100670778492	3.0706813623272e-10	Cocaine addiction: NFKB1
hsa05110__50	4.7391672171706e-11	DOWN	-6.57960649359178	3.0706813623272e-10	Vibrio cholerae infection: ACTB
hsa05200__129 130	4.73921019198983e-11	UP	6.57960649359178	3.0706813623272e-10	Pathways in cancer: CTBP1 HDAC1
hsa05220__12 13	4.73921019198983e-11	UP	6.57960649359178	3.0706813623272e-10	Chronic myeloid leukemia: HDAC1 CTBP1
hsa04210__69	4.78404005114841e-11	DOWN	-6.57820627939863	3.08907603302676e-10	Apoptosis: PTPN13
hsa05219__21	5.10967531440513e-11	UP	6.56840478004661	3.28804106704357e-10	Bladder cancer: RB1
hsa04340__31	5.35544768368765e-11	DOWN	-6.56140370908088	3.43443214936829e-10	Hedgehog signaling pathway: GLI1***
hsa05222__44	5.45696205081083e-11	UP	6.55860328069459	3.48762982771209e-10	Small cell lung cancer: RB1
hsa05032__25	5.50842269337455e-11	DOWN	-6.55720306650145	3.5085851663901e-10	Morphine addiction: C00575*
hsa04022__9	5.61277208307027e-11	UP	6.55440263811515	3.53905998123793e-10	cGMP-PKG signaling pathway: ITPR1
hsa04921__28	5.61277208307027e-11	UP	6.55440263811515	3.53905998123793e-10	Oxytocin signaling pathway: EEF2
hsa04921__67	5.61277208307027e-11	DOWN	-6.55440263811515	3.53905998123793e-10	Oxytocin signaling pathway: RYR1
hsa04622__11	5.71905429654392e-11	UP	6.55160220972886	3.59401438903211e-10	RIG-I-like receptor signaling pathway: IRF7
hsa04151__96	5.99344682530374e-11	DOWN	-6.54460113876313	3.75389552824858e-10	PI3K-Akt signaling pathway: BCL2
hsa04340__51	6.22219467793572e-11	DOWN	-6.53900028199055	3.87135887411961e-10	Hedgehog signaling pathway: CCND1*
hsa05200__52	6.22219467793572e-11	DOWN	-6.53900028199055	3.87135887411961e-10	Pathways in cancer: CDKN1B
hsa04623__25	6.3397489549594e-11	DOWN	-6.53619985360426	3.93148128262994e-10	Cytosolic DNA-sensing pathway: NFKB1*
hsa05231__34	6.39933790372739e-11	DOWN	-6.53479963941111	3.95538023720519e-10	Choline metabolism in cancer: PLD1
hsa04115__20	6.4594745415968e-11	UP	6.53339942521797	3.97945988972471e-10	p53 signaling pathway: RRM2B
hsa05205__318	6.96088335878537e-11	DOWN	-6.5221977116728	4.26042339777124e-10	Proteoglycans in cancer: HSPB2
hsa05214__52	6.96088335878537e-11	UP	6.5221977116728	4.26042339777124e-10	Glioma: E2F1*
hsa04115__19	7.22566673619925e-11	UP	6.51659685490022	4.40812590822025e-10	p53 signaling pathway: RFWD2
hsa04910__48	7.4306935348598e-11	DOWN	-6.51239621232078	4.51853500064775e-10	Insulin signaling pathway: PPARGC1A
hsa04740__42	7.71293327511883e-11	DOWN	-6.5067953555482	4.6750327819188e-10	Olfactory transduction: PDE2A
hsa04924__30	7.78511524522848e-11	UP	6.50539514135505	4.70361142951264e-10	Renin secretion: PDE3A
hsa05168__123	8.46519121872633e-11	UP	6.49279321361674	5.09810714743166e-10	Herpes simplex infection: CYCS
hsa04360__114	9.033981703216e-11	DOWN	-6.48299171426472	5.42327527806482e-10	Axon guidance: RAF1
hsa05213__31	9.46296784214284e-11	DOWN	-6.47599064329899	5.6627122851549e-10	Endometrial cancer: MYC
hsa04010__13	9.9118490990865e-11	UP	6.46898957233327	5.91249665307414e-10	MAPK signaling pathway: STMN1
hsa04630__33	1.05754271012288e-10	DOWN	-6.45918807298125	6.26852603255805e-10	Jak-STAT signaling pathway: RAF1
hsa04728__70 73	1.05754271012288e-10	DOWN	-6.45918807298125	6.26852603255805e-10	Dopaminergic synapse: KIF5A GRIA1
hsa04010__120	1.11786196724173e-10	DOWN	-6.45078678782237	6.60522841650067e-10	MAPK signaling pathway: NFATC1
hsa04066__59	1.18154002918382e-10	DOWN	-6.4423855026635	6.93785535886376e-10	HIF-1 signaling pathway: NOS2
hsa04066__43	1.18154002918382e-10	DOWN	-6.4423855026635	6.93785535886376e-10	HIF-1 signaling pathway: PFKL
hsa05152__98	1.22594770043406e-10	UP	6.43678464589091	7.17618607201122e-10	Tuberculosis: IL23A
hsa04261__4	1.27198535889984e-10	DOWN	-6.43118378911833	7.42254810364223e-10	Adrenergic signaling in cardiomyocytes: SLC8A1
hsa05220__19 41	1.33191365856628e-10	DOWN	-6.4241827181526	7.74819122119514e-10	Chronic myeloid leukemia: SMAD4 SMAD3
hsa04911__54	1.35665001228128e-10	DOWN	-6.42138228976631	7.86773263295221e-10	Insulin secretion: RAB3A
hsa04071__24	1.36918599538586e-10	DOWN	-6.41998207557316	7.91600149332316e-10	Sphingolipid signaling pathway: PTEN
hsa04310__22	1.38183516443948e-10	DOWN	-6.41858186138002	7.96462660730606e-10	Wnt signaling pathway: ROCK2
hsa04261__66	1.42047179930307e-10	DOWN	-6.41438121880058	8.16228290792192e-10	Adrenergic signaling in cardiomyocytes: C01245
hsa04261__72	1.46016351361702e-10	DOWN	-6.41018057622115	8.36477817709261e-10	Adrenergic signaling in cardiomyocytes: ATP2B1
hsa04390__13	1.47363338182882e-10	UP	6.408780362028	8.41628305305883e-10	Hippo signaling pathway: BIRC5
hsa04270__17	1.48722465475283e-10	DOWN	-6.40738014783485	8.46816704933505e-10	Vascular smooth muscle contraction: ITPR1
hsa04530__11 43	1.50093839972963e-10	DOWN	-6.40597993364171	8.5204327887975e-10	Tight junction: TJP1 ACTN4
hsa04022__23	1.54282527787157e-10	UP	6.40177929106227	8.7056117030651e-10	cGMP-PKG signaling pathway: CACNA1C
hsa04024__112	1.54282527787157e-10	DOWN	-6.40177929106227	8.7056117030651e-10	cAMP signaling pathway: GLI1
hsa05164__90	1.60045542637836e-10	DOWN	-6.39617843428969	9.00375971905673e-10	Influenza A: MAPK1
hsa03320__33	1.64505325801828e-10	DOWN	-6.39197779171025	9.22703006512343e-10	PPAR signaling pathway: CYP7A1
hsa04012__25	1.69086464451134e-10	DOWN	-6.38777714913081	9.45575793760957e-10	ErbB signaling pathway: CDKN1B
hsa04919__39	1.75389000454885e-10	DOWN	-6.38217629235823	9.77910777016999e-10	Thyroid hormone signaling pathway: ESR1
hsa04115__39	2.04833534524214e-10	UP	6.35837265107475	1.13870476736982e-09	p53 signaling pathway: BAX
hsa04530__20 22	2.08600089540716e-10	DOWN	-6.35557222268846	1.15282225955001e-09	Tight junction: ACTB MYL12B
hsa05210__9 11	2.08600089540716e-10	DOWN	-6.35557222268846	1.15282225955001e-09	Colorectal cancer: SMAD2 SMAD4
hsa04922__24	2.12271068153457e-10	UP	6.34717093752959	1.16966961014764e-09	Glucagon signaling pathway: PFKL
hsa04921__56	2.16337276167804e-10	DOWN	-6.34997136591588	1.18858988865293e-09	Oxytocin signaling pathway: JUN
hsa04923__43	2.18314957434269e-10	DOWN	-6.34857115172273	1.19595861521572e-09	Regulation of lipolysis in adipocytes: C00219
hsa04668__120	2.20310295432369e-10	UP	6.34717093752959	1.20338094510878e-09	TNF signaling pathway: DNM1L
hsa04015__95	2.2232344385436e-10	DOWN	-6.34577072333644	1.21085724928215e-09	Rap1 signaling pathway: THBS1
hsa04064__134	2.30557261411608e-10	DOWN	-6.34016986656386	1.25207252656766e-09	NF-kappa B signaling pathway: CCL21
hsa04722__84	2.39088684109682e-10	DOWN	-6.33456900979128	1.29466177937202e-09	Neurotrophin signaling pathway: NFKB1*
hsa04261__52	2.47928191367089e-10	DOWN	-6.32896815301869	1.33102020451075e-09	Adrenergic signaling in cardiomyocytes: MAPK14
hsa04932__58	2.47928191367089e-10	UP	6.32896815301869	1.33102020451075e-09	Non-alcoholic fatty liver disease (NAFLD): BAX
hsa05100__55	2.47928191367089e-10	DOWN	-6.32896815301869	1.33102020451075e-09	Bacterial invasion of epithelial cells: ACTB*
hsa04014__45	2.61788920320774e-10	DOWN	-6.32056686785982	1.40142843670295e-09	Ras signaling pathway: RAB5A
hsa04270__46	2.66575182907282e-10	UP	6.31776643947353	1.41495697368018e-09	Vascular smooth muscle contraction: ITPR1*
hsa04664__30	2.66575182907282e-10	DOWN	-6.31776643947353	1.41495697368018e-09	Fc epsilon RI signaling pathway: PRKCA
hsa04810__48	2.66575182907282e-10	DOWN	-6.31776643947353	1.41495697368018e-09	Regulation of actin cytoskeleton: IQGAP2
hsa04540__21	2.8145225168282e-10	DOWN	-6.30936515431465	1.48553152438928e-09	Gap junction: C03758
hsa04340__32	2.81452486792221e-10	DOWN	-6.30936515431465	1.48553152438928e-09	Hedgehog signaling pathway: PTCH1***
hsa05031__8	2.89181557974979e-10	DOWN	-6.30516451173522	1.52205083315122e-09	Amphetamine addiction: DRD1
hsa04728__54	2.91817960384853e-10	DOWN	-6.30376429754207	1.5316367250367e-09	Dopaminergic synapse: CAMK2A
hsa05205__304	3.02555896513719e-10	DOWN	-6.29816344076949	1.58357250570829e-09	Proteoglycans in cancer: MAPK1*****
hsa04340__50	3.13679329932005e-10	DOWN	-6.2925625839969	1.63723183595066e-09	Hedgehog signaling pathway: BCL2
hsa04630__34	3.31116895606479e-10	DOWN	-6.28416129883803	1.72345885552514e-09	Jak-STAT signaling pathway: AOX1
hsa04930__9	3.46366166770236e-10	UP	6.2771602278723	1.79785090431291e-09	Type II diabetes mellitus: C00238
hsa04390__58	3.59061052313369e-10	DOWN	-6.27155937109972	1.85861079145129e-09	Hippo signaling pathway: SMAD7
hsa04950__20	3.62304558522045e-10	UP	6.27015915690657	1.870247982041e-09	Maturity onset diabetes of the young: NKX6-1
hsa04921__55	3.68877612839002e-10	DOWN	-6.26735872852028	1.89896173842325e-09	Oxytocin signaling pathway: PTGS2*
hsa03320__39	3.78956015292939e-10	UP	6.26315808594084	1.9455146249602e-09	PPAR signaling pathway: MMP1
hsa04725__50	3.89303061334122e-10	DOWN	-6.25895744336141	1.99318924317933e-09	Cholinergic synapse: BCL2
hsa04923__26 27	4.25818700607048e-10	UP	6.24495530142995	2.17422102837131e-09	Regulation of lipolysis in adipocytes: PNPLA2 ABHD5
hsa04920__43	4.2965522862729e-10	DOWN	-6.2435550872368	2.18786497179046e-09	Adipocytokine signaling pathway: C00162
hsa05215__43	4.57423572444325e-10	DOWN	-6.23375358788478	2.32296998006186e-09	Prostate cancer: C05981
hsa05205__142	5.37145107048125e-10	UP	6.20854973240816	2.72047346669387e-09	Proteoglycans in cancer: CTNNB1
hsa04066__50	5.46797945370276e-10	DOWN	-6.20574930402187	2.76191757889986e-09	HIF-1 signaling pathway: TF
hsa05034__61	5.6661411286181e-10	DOWN	-6.20014844724929	2.85433758194997e-09	Alcoholism: CRH
hsa04520__44 49	5.71676625521866e-10	DOWN	-6.19874823305614	2.8721400517529e-09	Adherens junction: ACTB VCL
hsa04152__30	5.76783264873431e-10	UP	6.19734801886299	2.89006867919247e-09	AMPK signaling pathway: ACACA
hsa04360__3	5.92371703793022e-10	DOWN	-6.19314737628356	2.96028306230609e-09	Axon guidance: GNAI1
hsa04933__24	5.97658626167866e-10	DOWN	-6.19174716209041	2.97878132246531e-09	AGE-RAGE signaling pathway in diabetic complications: THBD
hsa05231__39	6.19270538408346e-10	UP	6.18614630531783	3.07833159171768e-09	Choline metabolism in cancer: EIF4EBP1
hsa04933__43	6.41644287653888e-10	UP	6.18054544854524	3.18113355277482e-09	AGE-RAGE signaling pathway in diabetic complications: CASP3
hsa04152__38	6.76690208213028e-10	UP	6.17214416338637	3.33727537714857e-09	AMPK signaling pathway: PFKL
hsa04261__37	6.76690749703889e-10	DOWN	-6.17214416338637	3.33727537714857e-09	Adrenergic signaling in cardiomyocytes: CREB3
hsa04010__86	6.88782682161696e-10	UP	6.16934373500008	3.37037150984851e-09	MAPK signaling pathway: MAP4K2
hsa04014__38	6.88782682161696e-10	DOWN	-6.16934373500008	3.37037150984851e-09	Ras signaling pathway: MAPK8
hsa04015__63	6.88782682161696e-10	DOWN	-6.16934373500008	3.37037150984851e-09	Rap1 signaling pathway: GNAI1
hsa05166__60	7.26337036234048e-10	UP	6.1609424498412	3.54490205476305e-09	HTLV-I infection: POLD3
hsa04931__13	7.52475210197426e-10	DOWN	-6.15534159306862	3.66295575119421e-09	Insulin resistance: AKT2
hsa04910__43	7.7953010722549e-10	DOWN	-6.14974073629604	3.78485031389327e-09	Insulin signaling pathway: G6PC
hsa04014__67	8.58916957921053e-10	DOWN	-6.13433838017144	4.15954887611767e-09	Ras signaling pathway: RAPGEF5*
hsa05215__9	9.13484780797695e-10	DOWN	-6.12453688081942	4.41243676894311e-09	Prostate cancer: CDKN1B
hsa04014__26	9.21551133047097e-10	DOWN	-6.12313666662627	4.43998609998845e-09	Ras signaling pathway: PRKCA
hsa04916__15	9.54516862440608e-10	DOWN	-6.11753580985369	4.58705162282839e-09	Melanogenesis: MITF*
hsa04110__96 97	9.62936319687834e-10	DOWN	-6.11613559566054	4.61570751197306e-09	Cell cycle: TFDP1 E2F4
hsa04728__24	9.7142818161375e-10	DOWN	-6.1147353814674	4.63277551586862e-09	Dopaminergic synapse: SLC6A3
hsa05200__211	9.7142818161375e-10	DOWN	-6.1147353814674	4.63277551586862e-09	Pathways in cancer: CXCL8
hsa04360__145	9.79993054083479e-10	DOWN	-6.11333516727425	4.65001754702742e-09	Axon guidance: ABLIM3
hsa05169__31	9.79993054083479e-10	DOWN	-6.11333516727425	4.65001754702742e-09	Epstein-Barr virus infection: MYC
hsa04920__3	9.8863154788366e-10	DOWN	-6.1119349530811	4.67919062587758e-09	Adipocytokine signaling pathway: C15493
hsa04110__48	9.97344278761183e-10	UP	6.11053473888796	4.70856758741775e-09	Cell cycle: RB1*
hsa03320__22	1.03295006378237e-09	DOWN	-6.10493388211538	4.84018246844657e-09	PPAR signaling pathway: ACADM
hsa04350__41	1.03295006378237e-09	DOWN	-6.10493388211538	4.84018246844657e-09	TGF-beta signaling pathway: SMAD4***
hsa05010__12	1.03295006378237e-09	UP	6.10493388211538	4.84018246844657e-09	Alzheimer's disease: CASP3
hsa04066__58	1.04204339260416e-09	DOWN	-6.10353366792223	4.85855963946208e-09	HIF-1 signaling pathway: EDN1
hsa04211__50	1.04204339260416e-09	DOWN	-6.10353366792223	4.85855963946208e-09	Longevity regulating pathway - mammal: PPARGC1A*
hsa05200__205	1.06979421822659e-09	UP	6.09933302534279	4.9756023169499e-09	Pathways in cancer: SLC2A1
hsa04920__2	1.07920362938671e-09	DOWN	-6.09793281114965	5.00697190029045e-09	Adipocytokine signaling pathway: C00638
hsa05132__86	1.08869371663271e-09	DOWN	-6.0965325969565	5.03856032894794e-09	Salmonella infection: MYH9
hsa04210__83	1.10791861662739e-09	DOWN	-6.09373216857021	5.11493631607585e-09	Apoptosis: TP53*
hsa04010__67	1.11765479166173e-09	UP	6.09233195437706	5.1346536761183e-09	MAPK signaling pathway: ELK1
hsa04933__52	1.11765479166173e-09	DOWN	-6.09233195437706	5.1346536761183e-09	AGE-RAGE signaling pathway in diabetic complications: FOXO1
hsa04931__140	1.14736650684016e-09	UP	6.08813131179763	5.25829674720161e-09	Insulin resistance: G00369
hsa04611__43	1.18818255359879e-09	DOWN	-6.08253045502504	5.43210466718278e-09	Platelet activation: MYL12B
hsa04151__2	1.20911799185858e-09	DOWN	-6.07973002663875	5.51439977354919e-09	PI3K-Akt signaling pathway: EIF4E
hsa04530__11 36 14	1.21972013311866e-09	DOWN	-6.07832981244561	5.5358795413767e-09	Tight junction: TJP1 CTNNB1 CTNNA1
hsa05205__120	1.21972013311866e-09	UP	6.07832981244561	5.5358795413767e-09	Proteoglycans in cancer: PLAU
hsa05164__68	1.23041288340362e-09	UP	6.07692959825246	5.570953754013e-09	Influenza A: EIF2S1
hsa04550__66	1.24119699594154e-09	DOWN	-6.07552938405932	5.60627200811093e-09	Signaling pathways regulating pluripotency of stem cells: MYC
hsa04152__87	1.28526234684459e-09	DOWN	-6.06992852728673	5.77753098019375e-09	AMPK signaling pathway: CD36
hsa05166__89 90	1.28526234684459e-09	DOWN	-6.06992852728673	5.77753098019375e-09	HTLV-I infection: CHUK IKBKG
hsa04066__42	1.29651478339753e-09	DOWN	-6.06852831309359	5.81420352745573e-09	HIF-1 signaling pathway: HK1
hsa05216__5	1.35423316143543e-09	UP	6.06152724212786	6.05858121508851e-09	Thyroid cancer: MAPK1
hsa05133__46	1.43926429129393e-09	DOWN	-6.05172574277584	6.42369977040689e-09	Pertussis: CFL1
hsa05031__96	1.45182999671885e-09	DOWN	-6.05032552858269	6.46442787638557e-09	Amphetamine addiction: PDYN
hsa04024__108	1.50316610147193e-09	UP	6.04472467181011	6.6771846445999e-09	cAMP signaling pathway: AMH
hsa04922__36	1.55626976550697e-09	UP	6.03912381503753	6.89677096553679e-09	Glucagon signaling pathway: GYS1
hsa04024__101	1.58350283800287e-09	UP	6.03632338665123	7.00094548848798e-09	cAMP signaling pathway: HCN4
hsa04066__56	1.61120012469361e-09	DOWN	-6.03352295826494	7.10667848427065e-09	HIF-1 signaling pathway: TEK
hsa04261__62	1.65363331648518e-09	DOWN	-6.02932231568551	7.27676112804601e-09	Adrenergic signaling in cardiomyocytes: BCL2
hsa04740__10	1.68252506234121e-09	DOWN	-6.02652188729922	7.38659951434377e-09	Olfactory transduction: ANO2
hsa04962__22	1.71190848955345e-09	DOWN	-6.02372145891292	7.4980793749905e-09	Vasopressin-regulated water reabsorption: ARHGDIA
hsa05014__13	1.96568031663587e-09	UP	6.00131803182259	8.58956584874137e-09	Amyotrophic lateral sclerosis (ALS): CASP3
hsa04933__56	2.01718284975631e-09	DOWN	-5.99711738924315	8.79416838675663e-09	AGE-RAGE signaling pathway in diabetic complications: NFATC1
hsa04664__3 4 5	2.05222092816019e-09	DOWN	-5.99431696085686	8.92621093521525e-09	Fc epsilon RI signaling pathway: FCER1G MS4A2 FCER1A
hsa05016__60	2.14252088425831e-09	UP	5.98731588989113	9.27602935834414e-09	Huntington's disease: CASP3*
hsa05134__35	2.14252088425831e-09	UP	5.98731588989113	9.27602935834414e-09	Legionellosis: CASP3
hsa04510__24 69	2.19853058676505e-09	DOWN	-5.9831152473117	9.49664131616443e-09	Focal adhesion: ZYX ACTB
hsa05162__23	2.21751551050684e-09	UP	5.98171503311855	9.55667808312466e-09	Measles: IRF3
hsa04550__67	2.29506491273156e-09	DOWN	-5.97611417634597	9.86825393826681e-09	Signaling pathways regulating pluripotency of stem cells: MYC*
hsa04810__30	2.37525360671891e-09	DOWN	-5.97051331957339	1.01897295137553e-08	Regulation of actin cytoskeleton: VCL*
hsa04115__36	2.54390055680682e-09	UP	5.95931160602822	1.08883579641003e-08	p53 signaling pathway: EI24
hsa04530__11 20 16	2.6325417219641e-09	DOWN	-5.95371074925564	1.12166573595704e-08	Tight junction: TJP1 ACTB CTTN
hsa04740__39	2.6325417219641e-09	DOWN	-5.95371074925564	1.12166573595704e-08	Olfactory transduction: PRKG1*
hsa04213__61	2.65516777799869e-09	DOWN	-5.95231053506249	1.12874666399537e-08	Longevity regulating pathway - multiple species: ATG5
hsa05012__57	2.74758088389259e-09	UP	5.94670967828991	1.16539604533503e-08	Parkinson's disease: CASP3
hsa04924__58	3.04401150584442e-09	DOWN	-5.92990710797216	1.28532530774869e-08	Renin secretion: PPP3CA
hsa05031__59	3.04401150584442e-09	DOWN	-5.92990710797216	1.28532530774869e-08	Amphetamine addiction: PPP3CA
hsa04730__8	3.76497184125073e-09	DOWN	-5.89490175314352	1.58618432504711e-08	Long-term depression: GNA13*
hsa04012__57	3.79702585037586e-09	DOWN	-5.89350153895037	1.59610997155621e-08	ErbB signaling pathway: ABL1
hsa05217__3	3.96132254122144e-09	DOWN	-5.88650046798464	1.66145648548105e-08	Basal cell carcinoma: GLI1
hsa04151__24	4.02896090472678e-09	DOWN	-5.88370003959835	1.68231500888481e-08	PI3K-Akt signaling pathway: MYC
hsa04933__28	4.02896090472678e-09	DOWN	-5.88370003959835	1.68231500888481e-08	AGE-RAGE signaling pathway in diabetic complications: VCAM1
hsa05168__79	4.13253078605478e-09	UP	5.87949939701891	1.72173511019888e-08	Herpes simplex infection: EIF2S1
hsa04066__64	4.16762644491677e-09	DOWN	-5.87809918282577	1.73251550663686e-08	HIF-1 signaling pathway: LTBR
hsa04014__54	4.49682109616932e-09	DOWN	-5.86549725508746	1.86523771295853e-08	Ras signaling pathway: RHOA
hsa04921__54	4.53492380506775e-09	DOWN	-5.86409704089431	1.87689908143663e-08	Oxytocin signaling pathway: RCAN1
hsa04151__100	4.65112667312971e-09	DOWN	-5.85989639831487	1.9123560216216e-08	PI3K-Akt signaling pathway: PRKCA
hsa05142__36	4.65112667312971e-09	DOWN	-5.85989639831487	1.9123560216216e-08	Chagas disease (American trypanosomiasis): SMAD2
hsa05152__15	4.65112667312971e-09	DOWN	-5.85989639831487	1.9123560216216e-08	Tuberculosis: CTSD
hsa04630__28	5.10251409035756e-09	UP	5.84449404219027	2.09336768030171e-08	Jak-STAT signaling pathway: CCND1
hsa05034__62	5.14560144982767e-09	DOWN	-5.84309382799712	2.10644556083359e-08	Alcoholism: NPY
hsa04932__28	5.2769983925288e-09	UP	5.83889318541769	2.15553912599165e-08	Non-alcoholic fatty liver disease (NAFLD): GSK3A
hsa04931__144	5.59641376320308e-09	DOWN	-5.82909168606567	2.28105454686737e-08	Insulin resistance: C00533*
hsa04152__49	5.64355312935661e-09	UP	5.82769147187252	2.29528924893097e-08	AMPK signaling pathway: GYS1
hsa04930__8	5.73899348659615e-09	UP	5.82489104348623	2.32404499166254e-08	Type II diabetes mellitus: C00022
hsa04961__5	5.73899348659615e-09	DOWN	-5.82489104348623	2.32404499166254e-08	Endocrine and other factor-regulated calcium reabsorption: TRPV5
hsa05166__26	5.93460748651021e-09	DOWN	-5.81929018671365	2.39809192841993e-08	HTLV-I infection: NFATC1
hsa04071__11	6.45244893864556e-09	DOWN	-5.80528804478219	2.60174926088305e-08	Sphingolipid signaling pathway: PRKCA
hsa05145__11	6.50658742898395e-09	UP	5.80388783058904	2.61796098052695e-08	Toxoplasmosis: MAPK14
hsa04360__4	6.61619302215188e-09	DOWN	-5.80108740220275	2.65637322406483e-08	Axon guidance: GNAI1*
hsa05217__10	6.84081748471452e-09	DOWN	-5.79548654543017	2.74070278332166e-08	Basal cell carcinoma: PTCH1*
hsa04742__18	7.25188270578007e-09	DOWN	-5.78568504607815	2.89921012854484e-08	Taste transduction: PDE1A
hsa05164__99	7.3736767375689e-09	UP	5.78288461769186	2.94164301271591e-08	Influenza A: FDPS
hsa04650__35	7.62326091200951e-09	UP	5.77728376091928	3.03476848594616e-08	Natural killer cell mediated cytotoxicity: BID
hsa05200__121 122	7.81582073892338e-09	DOWN	-5.77308311833984	3.09829687097828e-08	Pathways in cancer: SMAD2 SMAD4
hsa05212__38 39	7.81582073892338e-09	DOWN	-5.77308311833984	3.09829687097828e-08	Pancreatic cancer: SMAD2 SMAD4
hsa04261__3	7.94681273450214e-09	DOWN	-5.77028268995355	3.14359181644832e-08	Adrenergic signaling in cardiomyocytes: RYR2
hsa04390__77	8.14731186203902e-09	DOWN	-5.76608204737411	3.20939182154535e-08	Hippo signaling pathway: CCND1
hsa04972__21	8.14731186203902e-09	DOWN	-5.76608204737411	3.20939182154535e-08	Pancreatic secretion: KCNQ1
hsa04360__108	8.49245689516943e-09	DOWN	-5.75908097640838	3.3383528255279e-08	Axon guidance: CFL1
hsa04530__1 5	9.45770415806265e-09	DOWN	-5.74087819189749	3.70229710687494e-08	Tight junction: IGSF5 IGSF5
hsa04730__30	9.45770415806265e-09	DOWN	-5.74087819189749	3.70229710687494e-08	Long-term depression: C00025*
hsa04726__10	9.69515657537898e-09	DOWN	-5.73667754931805	3.78735950210751e-08	Serotonergic synapse: PRKACA
hsa05216__11	9.85666693903118e-09	DOWN	-5.73387712093176	3.84246414490448e-08	Thyroid cancer: MYC
hsa04724__44	9.93839983497666e-09	DOWN	-5.73247690673861	3.86630502896918e-08	Glutamatergic synapse: PRKACA*
hsa04666__41	1.00207913351118e-08	UP	5.73107669254547	3.88228183890207e-08	Fc gamma R-mediated phagocytosis: MARCKS
hsa05211__42	1.00207913351118e-08	UP	5.73107669254547	3.88228183890207e-08	Renal cell carcinoma: SLC2A1*
hsa04950__31	1.08820807360269e-08	UP	5.71707455061401	4.20729006234457e-08	Maturity onset diabetes of the young: NKX6-1*
hsa04664__47	1.15273518414597e-08	DOWN	-5.70727305126199	4.44761686039073e-08	Fc epsilon RI signaling pathway: MAPK8
hsa04012__47	1.18151418939907e-08	DOWN	-5.70307240868255	4.53074522832826e-08	ErbB signaling pathway: PRKCA
hsa04930__10	1.18151418939907e-08	UP	5.70307240868255	4.53074522832826e-08	Type II diabetes mellitus: C00031
hsa05016__22 9	1.18151418939907e-08	UP	5.70307240868255	4.53074522832826e-08	Huntington's disease: DLG4 HTT
hsa04921__76	1.21099087787223e-08	DOWN	-5.69887176610311	4.63432150615461e-08	Oxytocin signaling pathway: CDKN1A
hsa04520__10	1.26171375874112e-08	UP	5.69187069513739	4.80884412307215e-08	Adherens junction: NLK
hsa05161__66 67	1.26171375874112e-08	DOWN	-5.69187069513739	4.80884412307215e-08	Hepatitis B: NFKB1 NFKBIA
hsa05215__22	1.26927249003446e-08	UP	3.60835197573654	4.82786034164931e-08	Prostate cancer: C16038
hsa04211__42	1.29313203313112e-08	DOWN	-5.68767005255795	4.9086769500068e-08	Longevity regulating pathway - mammal: PPARGC1A
hsa04211__39	1.32530989200879e-08	UP	5.68346940997851	5.01057804242359e-08	Longevity regulating pathway - mammal: TP53*
hsa05166__132 136	1.32530989200879e-08	UP	5.68346940997851	5.01057804242359e-08	HTLV-I infection: CREBBP TP53
hsa04910__14	1.3582651179701e-08	DOWN	-5.67926876739907	5.12485975234099e-08	Insulin signaling pathway: C00369
hsa04020__64	1.51050604736251e-08	DOWN	-5.66106598288818	5.67648172598831e-08	Calcium signaling pathway: C01330*
hsa04020__12	1.51050604736251e-08	DOWN	-5.66106598288818	5.67648172598831e-08	Calcium signaling pathway: C01330
hsa04530__4 53	1.53535276731242e-08	UP	5.65826555450189	5.74686822665346e-08	Tight junction: OCLN OCLN
hsa04530__4 45	1.53535276731242e-08	UP	5.65826555450189	5.74686822665346e-08	Tight junction: OCLN TJP2
hsa05134__71	1.58624273217133e-08	UP	5.65266469772931	5.92554690606349e-08	Legionellosis: CXCL8
hsa04115__24	1.62548154981115e-08	UP	5.64846405514987	6.06007903193484e-08	p53 signaling pathway: SERPINB5
hsa04921__48	1.66566240751012e-08	DOWN	-5.64426341257043	6.19758349249805e-08	Oxytocin signaling pathway: PRKAG2
hsa04152__24	1.69298379153217e-08	DOWN	-5.64146298418414	6.28679158950385e-08	AMPK signaling pathway: SIRT1
hsa05030__77	1.70680719561301e-08	DOWN	-5.64006276999099	6.32562272299181e-08	Cocaine addiction: BDNF
hsa05205__77	1.74893595070962e-08	DOWN	-5.63586212741156	6.45629677141561e-08	Proteoglycans in cancer: MIR21
hsa04911__31	1.7489382951839e-08	DOWN	-5.63586212741156	6.45629677141561e-08	Insulin secretion: CAMK2A
hsa04152__94	1.76320511569516e-08	DOWN	-5.63446191321841	6.49620080861019e-08	AMPK signaling pathway: MLYCD
hsa03320__7	1.77758492468719e-08	DOWN	-5.63306169902527	6.52359779977975e-08	PPAR signaling pathway: AQP7
hsa04380__20	1.77758492468719e-08	UP	5.63306169902527	6.52359779977975e-08	Osteoclast differentiation: MAP2K1
hsa04064__55	1.8662855073608e-08	DOWN	-5.62466041386639	6.80922421035134e-08	NF-kappa B signaling pathway: CXCL12
hsa05166__114 112 113	1.8662855073608e-08	DOWN	-5.62466041386639	6.80922421035134e-08	HTLV-I infection: DLG1 CTNNB1 APC2
hsa05321__152	1.8662855073608e-08	UP	5.62466041386639	6.80922421035134e-08	Inflammatory bowel disease (IBD): FOXP3*
hsa04921__33	1.9122327828221e-08	DOWN	-5.62045977128695	6.96334379636188e-08	Oxytocin signaling pathway: C00942
hsa05205__422	1.95927109784519e-08	DOWN	-5.61625912870752	7.10710935750667e-08	Proteoglycans in cancer: CD63
hsa04068__88	1.95927761957874e-08	DOWN	-5.61625912870752	7.10710935750667e-08	FoxO signaling pathway: FBXO32
hsa04360__122	1.97520750275218e-08	DOWN	-5.61485891451437	7.13733634167566e-08	Axon guidance: CFL1**
hsa04724__66	1.97520750275218e-08	DOWN	-5.61485891451437	7.13733634167566e-08	Glutamatergic synapse: PLA2G4B
hsa04920__37	2.05676201418591e-08	DOWN	-5.60785784354864	7.41776549837873e-08	Adipocytokine signaling pathway: IRS1
hsa04722__50	2.09029109124929e-08	UP	5.60505741516235	7.50986034504286e-08	Neurotrophin signaling pathway: RHOA
hsa05030__78	2.09029109124929e-08	DOWN	-5.60505741516235	7.50986034504286e-08	Cocaine addiction: GRIA2
hsa04932__35	2.12435054459759e-08	DOWN	-5.60225698677606	7.61766159026503e-08	Non-alcoholic fatty liver disease (NAFLD): PRKAG2
hsa04970__21	2.39754160346721e-08	DOWN	-5.58125377387887	8.58091556745692e-08	Salivary secretion: ITPR1
hsa05211__4	2.43644941389132e-08	UP	5.57845334549258	8.7035902066574e-08	Renal cell carcinoma: SLC2A1
hsa04622__45	2.45613243233107e-08	UP	5.57705313129944	8.7572539665087e-08	RIG-I-like receptor signaling pathway: MAPK14
hsa04923__38	2.4959625043011e-08	DOWN	-5.57425270291315	8.88241201814728e-08	Regulation of lipolysis in adipocytes: PDE3B
hsa04630__35	2.57751185541379e-08	DOWN	-5.56865184614056	9.15528313104444e-08	Jak-STAT signaling pathway: MTOR
hsa04925__33	2.64036480966423e-08	DOWN	-5.56445120356112	9.36084052331903e-08	Aldosterone synthesis and secretion: CYP11B2
hsa04916__9	2.79286042712304e-08	DOWN	-5.5546497042091	9.88283379013972e-08	Melanogenesis: PRKACA
hsa04810__29	2.81533146107048e-08	DOWN	-5.55324949001596	9.9436237130666e-08	Regulation of actin cytoskeleton: ACTN4
hsa04115__64	2.86080101637318e-08	UP	5.55044906162967	1.00852628701036e-07	p53 signaling pathway: PMAIP1
hsa04932__55	2.9069827642361e-08	UP	5.54764863324338	1.02288775543064e-07	Non-alcoholic fatty liver disease (NAFLD): CASP3
hsa04390__79	2.97761438722798e-08	DOWN	-5.54344799066394	1.04578269786942e-07	Hippo signaling pathway: SNAI2
hsa04024__76	3.00152614417367e-08	DOWN	-5.54204777647079	1.05221410912357e-07	cAMP signaling pathway: C00416
hsa03320__43	3.1239069660639e-08	DOWN	-5.53504670550506	1.09307657155197e-07	PPAR signaling pathway: ILK
hsa04550__47	3.14895750359764e-08	DOWN	-5.53364649131192	1.09979389391449e-07	Signaling pathways regulating pluripotency of stem cells: CTNNB1*
hsa04390__12	3.19964452795284e-08	DOWN	-5.53084606292563	1.11542338924367e-07	Hippo signaling pathway: CTGF
hsa05166__136 139	3.25112264036153e-08	UP	5.52804563453934	1.13127026689617e-07	HTLV-I infection: TP53 TBPL2
hsa03320__20	3.27716207806907e-08	DOWN	-5.52664542034619	1.13612316322727e-07	PPAR signaling pathway: SCP2
hsa04920__6	3.27716207806907e-08	DOWN	-5.52664542034619	1.13612316322727e-07	Adipocytokine signaling pathway: PTPN11
hsa03460__16 49	3.46518732265216e-08	UP	5.51684392099417	1.19909520796748e-07	Fanconi anemia pathway: FANCM C19orf40
hsa04971__49	3.49288801405468e-08	DOWN	-5.51544370680102	1.20645892985455e-07	Gastric acid secretion: KCNJ1
hsa05168__106 134	3.54893518948685e-08	UP	5.51264327841473	1.22356866441207e-07	Herpes simplex infection: SRSF8 C1QBP
hsa03320__38	3.66365818113677e-08	DOWN	-5.50704242164215	1.25850342273418e-07	PPAR signaling pathway: SORBS1
hsa04071__68	3.66365818113677e-08	DOWN	-5.50704242164215	1.25850342273418e-07	Sphingolipid signaling pathway: NFKB1
hsa04261__34	3.69289617279142e-08	DOWN	-5.505642207449	1.26623210012319e-07	Adrenergic signaling in cardiomyocytes: AKT3
hsa04010__107	3.8121275254133e-08	DOWN	-5.50004135067642	1.30236138550029e-07	MAPK signaling pathway: MAP3K2
hsa04066__29	3.8121275254133e-08	DOWN	-5.50004135067642	1.30236138550029e-07	HIF-1 signaling pathway: LDHA
hsa04068__44	3.84251376393382e-08	DOWN	-5.49864113648328	1.30798611638255e-07	FoxO signaling pathway: CDKN1B
hsa05152__76	3.84251376393382e-08	UP	5.49864113648328	1.30798611638255e-07	Tuberculosis: TNF*
hsa04211__57	3.87313482736197e-08	DOWN	-5.49724092229013	1.31602537804939e-07	Longevity regulating pathway - mammal: ATG5
hsa05164__36	4.09420632529104e-08	DOWN	-5.48743942293811	1.38612859193187e-07	Influenza A: IL33
hsa05168__10	4.09420632529104e-08	DOWN	-5.48743942293811	1.38612859193187e-07	Herpes simplex infection: FOS
hsa04520__18	4.396478859475e-08	DOWN	-5.4748374951998	1.48578844909236e-07	Adherens junction: SNAI2
hsa05152__94	4.68324337417703e-08	UP	5.46363578165463	1.57985894076816e-07	Tuberculosis: CAMP
hsa04972__18	4.72033934163202e-08	DOWN	-5.46223556746149	1.58951928726282e-07	Pancreatic secretion: PRKCA
hsa04914__15	4.94896981997755e-08	UP	5.45383428230261	1.66352670692984e-07	Progesterone-mediated oocyte maturation: ANAPC10
hsa04730__7	5.06727445763129e-08	DOWN	-5.44963363972318	1.70025155462307e-07	Long-term depression: GNA13
hsa04662__32 51	5.10731502902749e-08	UP	5.44823342553003	1.71063189653167e-07	B cell receptor signaling pathway: BLNK GRB2
hsa05164__23	5.31216227056219e-08	UP	5.4412323545643	1.77607702960611e-07	Influenza A: IRF3
hsa05161__188	5.35407669764009e-08	UP	5.43983214037115	1.78691121045572e-07	Hepatitis B: IFNB1
hsa04740__16	5.39631156150754e-08	DOWN	-5.43843192617801	1.79781372767246e-07	Olfactory transduction: PRKG1
hsa04630__27	5.65658361404749e-08	UP	5.43003064101914	1.88118948863633e-07	Jak-STAT signaling pathway: PIM1
hsa04014__103	6.36160815803683e-08	DOWN	-5.40902742812195	2.1119190333836e-07	Ras signaling pathway: KSR2
hsa04710__7	6.41152212567052e-08	DOWN	-5.4076272139288	2.12473546281039e-07	Circadian rhythm: PER1
hsa04921__34 35	6.66683780904183e-08	DOWN	-5.40062614296307	2.20545567661789e-07	Oxytocin signaling pathway: MYL9 ACTB
hsa04152__15	6.8247258790157e-08	DOWN	-5.39642550038364	2.24582485580919e-07	AMPK signaling pathway: FOXO1
hsa05160__53	6.8247258790157e-08	UP	5.39642550038364	2.24582485580919e-07	Hepatitis C: EIF2S1
hsa05162__74	6.8247258790157e-08	UP	5.39642550038364	2.24582485580919e-07	Measles: EIF2S1
hsa04650__36	6.93199050321664e-08	UP	5.39362507199735	2.27713464257763e-07	Natural killer cell mediated cytotoxicity: CASP3
hsa04917__75	7.15144049534639e-08	UP	5.38802421522476	2.34512333172005e-07	Prolactin signaling pathway: CCND1**
hsa04012__23	7.32042886086949e-08	UP	5.38382357264533	2.39635641630205e-07	ErbB signaling pathway: RPS6KB1
hsa04742__46	7.37753611062335e-08	DOWN	-5.38242335845218	2.41085049597587e-07	Taste transduction: P2RY1
hsa03320__65	7.49328201498146e-08	DOWN	-5.37962293006589	2.44018663884751e-07	PPAR signaling pathway: ME1
hsa04913__19	7.49328201498146e-08	DOWN	-5.37962293006589	2.44018663884751e-07	Ovarian steroidogenesis: STAR
hsa04064__132	7.61070658973892e-08	DOWN	-5.3768225016796	2.4698648846493e-07	NF-kappa B signaling pathway: VCAM1
hsa05205__150	7.61070658973892e-08	DOWN	-5.3768225016796	2.4698648846493e-07	Proteoglycans in cancer: PRKCA
hsa04151__105 62	7.6700852261756e-08	UP	5.37542228748645	2.48484312758344e-07	PI3K-Akt signaling pathway: CCND1 CDK2
hsa04115__15	7.85092557051696e-08	UP	5.37122164490701	2.53905148829628e-07	p53 signaling pathway: TSC2
hsa04913__12	7.91211814109333e-08	DOWN	-5.36982143071387	2.55006346262682e-07	Ovarian steroidogenesis: HSD3B1
hsa05162__93	7.91211814109333e-08	UP	5.36982143071387	2.55006346262682e-07	Measles: TP53
hsa04020__16	8.09847997415817e-08	UP	5.36562078813443	2.60565819716493e-07	Calcium signaling pathway: C06124
hsa04360__11	8.28908935437535e-08	DOWN	-5.36142014555499	2.66242716185834e-07	Axon guidance: NFATC2
hsa05130__28	8.68342620702776e-08	DOWN	-5.35301886039612	2.78432727696334e-07	Pathogenic Escherichia coli infection: ROCK1
hsa04115__55	9.09589955455659e-08	UP	5.34461757523725	2.90666586105643e-07	p53 signaling pathway: SHISA5
hsa04510__47	9.09589955455659e-08	DOWN	-5.34461757523725	2.90666586105643e-07	Focal adhesion: CCND1
hsa04810__32	9.75038288130466e-08	DOWN	-5.33201564749893	3.11052112631094e-07	Regulation of actin cytoskeleton: PXN
hsa04630__30	1.00556869196789e-07	UP	5.32641479072635	3.20248063086046e-07	Jak-STAT signaling pathway: CDKN1A
hsa04723__42	1.01334468859133e-07	DOWN	-5.32501457653321	3.21634234774173e-07	Retrograde endocannabinoid signaling: KCNJ3
hsa04723__50	1.01334468859133e-07	DOWN	-5.32501457653321	3.21634234774173e-07	Retrograde endocannabinoid signaling: KCNJ3*
hsa04916__6	1.02117887329694e-07	DOWN	-5.32361436234006	3.23574216344848e-07	Melanogenesis: DCT
hsa04014__41	1.06942965325512e-07	DOWN	-5.31521307718118	3.3829264620646e-07	Ras signaling pathway: RAC1*
hsa04950__7	1.07768307748095e-07	UP	5.31381286298804	3.40330504636421e-07	Maturity onset diabetes of the young: FOXA3
hsa04540__16 17	1.08599813197714e-07	DOWN	-5.31241264879489	3.42380954695478e-07	Gap junction: GJA1 GJA1**
hsa04919__45	1.10281490998364e-07	DOWN	-5.3096122204086	3.47100371165704e-07	Thyroid hormone signaling pathway: SLC9A1
hsa05014__54	1.11131753028734e-07	DOWN	-5.30821200621546	3.4919157849664e-07	Amyotrophic lateral sclerosis (ALS): PPP3CA
hsa04066__49	1.11988357448885e-07	DOWN	-5.30681179202231	3.50710206077424e-07	HIF-1 signaling pathway: EPO
hsa04931__104	1.11988357448885e-07	UP	5.30681179202231	3.50710206077424e-07	Insulin resistance: C00369*
hsa04920__1	1.13720776245697e-07	UP	5.30401136363602	3.55542992621737e-07	Adipocytokine signaling pathway: C00195
hsa04742__48	1.15479116126092e-07	DOWN	-5.30121093524973	3.60440629901872e-07	Taste transduction: GABBR1
hsa04010__118	1.18166047177259e-07	DOWN	-5.29701029267029	3.68215593111227e-07	MAPK signaling pathway: JUN
hsa05217__5	1.1999083667715e-07	DOWN	-5.294209864284	3.73282751848286e-07	Basal cell carcinoma: BMP2
hsa04210__102	1.22779241418766e-07	DOWN	-5.29000922170456	3.81325941530349e-07	Apoptosis: PIDD1
hsa04380__68	1.27566467743487e-07	DOWN	-5.28300815073883	3.9554025229375e-07	Osteoclast differentiation: TGFBR1
hsa05205__17	1.28545349351591e-07	DOWN	-5.28160793654569	3.97918799722635e-07	Proteoglycans in cancer: AKT3
hsa05166__74	1.36642355666771e-07	DOWN	-5.27040622300052	4.22287806410959e-07	HTLV-I infection: NFKB1
hsa03320__55	1.37688524175819e-07	UP	5.26900600880738	4.24822228122107e-07	PPAR signaling pathway: SCD
hsa05152__13	1.38742438548708e-07	DOWN	-5.26760579461423	4.27372200054135e-07	Tuberculosis: LAMP1
hsa05140__16	1.39804154054452e-07	DOWN	-5.26620558042108	4.29937815823756e-07	Leishmaniasis: STAT1
hsa04520__44 47	1.47459317002184e-07	DOWN	-5.25640408106906	4.52738654652131e-07	Adherens junction: ACTB TJP1
hsa04919__84	1.54342205731896e-07	UP	5.24800279591019	4.73097886737738e-07	Thyroid hormone signaling pathway: TP53*
hsa04933__35	1.6031434942758e-07	DOWN	-5.24100172494446	4.90603684974629e-07	AGE-RAGE signaling pathway in diabetic complications: CCND1
hsa04115__22	1.65252367145462e-07	UP	5.23540086817188	5.04893004660688e-07	p53 signaling pathway: STEAP3
hsa04068__59	1.69052068330059e-07	DOWN	-5.23120022559244	5.15663695441852e-07	FoxO signaling pathway: S1PR1
hsa04810__21 82	1.70337304509085e-07	DOWN	-5.2298000113993	5.18741969485527e-07	Regulation of actin cytoskeleton: CFL1 ACTB
hsa04210__51	1.74249950017211e-07	DOWN	-5.22559936881986	5.29798796249739e-07	Apoptosis: LMNA
hsa05231__60	1.76906502027323e-07	DOWN	-5.22279894043357	5.37006974651598e-07	Choline metabolism in cancer: PRKCA
hsa05200__190	1.8651628464245e-07	DOWN	-5.21299744108155	5.6526467555349e-07	Pathways in cancer: MYC*
hsa04910__18	1.87929650135454e-07	DOWN	-5.2115972268884	5.67716740521733e-07	Insulin signaling pathway: LIPE
hsa04919__46	1.87929650135454e-07	DOWN	-5.2115972268884	5.67716740521733e-07	Thyroid hormone signaling pathway: ATP1B4
hsa04611__34	1.93687345928946e-07	DOWN	-5.20599637011582	5.84170983949422e-07	Platelet activation: C02198*
hsa04210__57	1.95153196961465e-07	UP	5.20459615592267	5.86708571344949e-07	Apoptosis: BAK1
hsa04210__105	1.95153196961465e-07	DOWN	-5.20459615592267	5.86708571344949e-07	Apoptosis: ACTB
hsa05031__101	1.96629768025779e-07	DOWN	-5.20319594172953	5.9020340913808e-07	Amphetamine addiction: FOS*
hsa04961__12	2.13601527959066e-07	DOWN	-5.18779358560492	6.40123239290405e-07	Endocrine and other factor-regulated calcium reabsorption: SLC8A1
hsa04810__82 83	2.20117297971066e-07	UP	5.18219272883234	6.58599367655465e-07	Regulation of actin cytoskeleton: ACTB ARPC5
hsa04072__57	2.23446795405537e-07	DOWN	-5.17939230044605	6.66438934233338e-07	Phospholipase D signaling pathway: C06124
hsa05032__13	2.23446795405537e-07	DOWN	-5.17939230044605	6.66438934233338e-07	Morphine addiction: PRKACA
hsa05152__97	2.2853245113902e-07	UP	5.17519165786661	6.80526902837113e-07	Tuberculosis: IL18
hsa04210__85	2.30252387995954e-07	DOWN	-5.17379144367347	6.84563666209489e-07	Apoptosis: FASLG*
hsa04750__53	2.44469430410542e-07	UP	5.1625897301283	7.25684138612019e-07	Inflammatory mediator regulation of TRP channels: TRPM8
hsa04072__27	2.48154076616369e-07	DOWN	-5.15978930174201	7.35459794892994e-07	Phospholipase D signaling pathway: C01245
hsa05200__209	2.55684982290146e-07	DOWN	-5.15418844496943	7.56585955469582e-07	Pathways in cancer: FIGF**
hsa05200__224	2.67396784230683e-07	DOWN	-5.14578715981055	7.88757547204793e-07	Pathways in cancer: MYC***
hsa05221__12	2.67396784230683e-07	DOWN	-5.14578715981055	7.88757547204793e-07	Acute myeloid leukemia: MYC
hsa04012__56	2.73445337810994e-07	DOWN	-5.14158651723112	8.05335093647113e-07	ErbB signaling pathway: JUN
hsa04921__11	2.79625930433125e-07	DOWN	-5.13738587465168	8.20964255131003e-07	Oxytocin signaling pathway: PRKACA
hsa05231__48	2.79625930433125e-07	DOWN	-5.13738587465168	8.20964255131003e-07	Choline metabolism in cancer: WAS
hsa05321__55	2.8807691195721e-07	DOWN	-5.13178501787909	8.44456345659277e-07	Inflammatory bowel disease (IBD): IL4*
hsa05200__217	2.92394372250623e-07	UP	5.1289845894928	8.55777298222616e-07	Pathways in cancer: E2F1*
hsa04622__21 22 23	2.96774284625211e-07	UP	5.12618416110651	8.67245537808354e-07	RIG-I-like receptor signaling pathway: CHUK IKBKB IKBKG
hsa04913__35	2.98987931306963e-07	DOWN	-5.12478394691337	8.72357644294695e-07	Ovarian steroidogenesis: HSD17B2
hsa04920__9	3.3170387620752e-07	UP	5.10518094820933	9.64816692560264e-07	Adipocytokine signaling pathway: G6PC
hsa05161__32	3.3170387620752e-07	DOWN	-5.10518094820933	9.64816692560264e-07	Hepatitis B: STAT3
hsa04022__60	3.34168545361771e-07	DOWN	-5.10378073401618	9.67492598974988e-07	cGMP-PKG signaling pathway: TRPC6*
hsa05131__38	3.34168545361771e-07	UP	5.10378073401618	9.67492598974988e-07	Shigellosis: CXCL8
hsa05152__120	3.34168545361771e-07	DOWN	-5.10378073401618	9.67492598974988e-07	Tuberculosis: TGFB1
hsa04210__86	3.41669085752483e-07	DOWN	-5.09958009143674	9.87686480198332e-07	Apoptosis: BCL2L11
hsa04922__37	3.44205185672833e-07	DOWN	-5.0981798772436	9.93489314714675e-07	Glucagon signaling pathway: PYGB
hsa04620__48	3.51922984546167e-07	UP	5.09397923466416	1.01420749687461e-06	Toll-like receptor signaling pathway: CD80
hsa04210__119	3.59807684895408e-07	DOWN	-5.08977859208472	1.03534248073273e-06	Apoptosis: BCL2*
hsa04014__62	3.62473604859884e-07	DOWN	-5.08837837789158	1.04141881273964e-06	Ras signaling pathway: RASSF5
hsa03320__61	3.70586245788399e-07	DOWN	-5.08417773531214	1.06310161196397e-06	PPAR signaling pathway: APOA1
hsa04360__33 134	3.81676101763657e-07	DOWN	-5.07857687853956	1.09158203228906e-06	Axon guidance: NCK1 PAK4
hsa05166__53 146	3.81676101763657e-07	DOWN	-5.07857687853956	1.09158203228906e-06	HTLV-I infection: CREB1 CRTC2
hsa04115__54	3.9598935331928e-07	UP	5.07157580757383	1.13079634481296e-06	p53 signaling pathway: PERP
hsa04750__90	3.98913510131544e-07	UP	5.07017559338068	1.1374180357165e-06	Inflammatory mediator regulation of TRP channels: C01245**
hsa04915__12 14	4.10819873117729e-07	DOWN	-5.0645747366081	1.16959172967911e-06	Estrogen signaling pathway: ESR1 FOS
hsa05231__50	4.13849617687794e-07	DOWN	-5.06317452241495	1.17643484362385e-06	Choline metabolism in cancer: WASF2
hsa04024__118	4.23068758263104e-07	DOWN	-5.05897387983552	1.20082507065917e-06	cAMP signaling pathway: MYL9
hsa04914__34	4.32485882780682e-07	DOWN	-5.05477323725608	1.22570282616124e-06	Progesterone-mediated oocyte maturation: MAPK14
hsa04668__48	4.42105073272243e-07	UP	5.05057259467664	1.25107745885323e-06	TNF signaling pathway: CASP3
hsa04612__39	4.58597435263865e-07	UP	5.04357152371091	1.29579636219669e-06	Antigen processing and presentation: PSME3
hsa05205__324	4.65359198176442e-07	DOWN	-5.04077109532462	1.31292782788819e-06	Proteoglycans in cancer: KDR*
hsa05164__31 32 33	4.72208927530537e-07	DOWN	-5.03797066693833	1.33025573437763e-06	Influenza A: NLRP3 PYCARD CASP1
hsa04062__60	4.89790920633193e-07	UP	5.0309695959726	1.37772026926612e-06	Chemokine signaling pathway: GSK3A
hsa04933__63	5.23025787261316e-07	DOWN	-5.01836766823429	1.4690066580927e-06	AGE-RAGE signaling pathway in diabetic complications: SELE
hsa03320__32	5.30701264354483e-07	DOWN	-5.015567239848	1.48833981451056e-06	PPAR signaling pathway: FABP3
hsa04722__37	5.34579618665245e-07	UP	5.01416702565485	1.49698227045007e-06	Neurotrophin signaling pathway: NFKB1
hsa04010__57	5.42418476686986e-07	UP	5.01136659726856	1.51667309180781e-06	MAPK signaling pathway: NLK
hsa04915__3 11	5.46379351108157e-07	DOWN	-5.00996638307542	1.52321483788164e-06	Estrogen signaling pathway: ESR1 C00951
hsa04915__12 13	5.46379351108157e-07	DOWN	-5.00996638307542	1.52321483788164e-06	Estrogen signaling pathway: ESR1 C00951*
hsa04012__48	5.70736700489704e-07	DOWN	-5.00156509791654	1.58641162754461e-06	ErbB signaling pathway: CAMK2A
hsa05200__48	5.70736700489704e-07	UP	5.00156509791654	1.58641162754461e-06	Pathways in cancer: MTOR
hsa04530__5 11 31	5.87552946530726e-07	DOWN	-4.99596424114396	1.6283362633204e-06	Tight junction: IGSF5 TJP1 MLLT4
hsa04911__24	5.87552946530726e-07	DOWN	-4.99596424114396	1.6283362633204e-06	Insulin secretion: INS
hsa04610__52	5.91831057166316e-07	UP	4.99456402695081	1.63777696084758e-06	Complement and coagulation cascades: CPB2
hsa04916__10	6.0484631549582e-07	DOWN	-4.99036338437138	1.67133268649507e-06	Melanogenesis: CAMK2A
hsa04360__35	6.18137249487669e-07	DOWN	-4.98616274179194	1.70555050189035e-06	Axon guidance: ROCK1*
hsa05010__59	6.22629786800552e-07	DOWN	-4.98476252759879	1.71542722785665e-06	Alzheimer's disease: LRP1
hsa05211__45	6.50253158642981e-07	DOWN	-4.97636124243992	1.78891022707198e-06	Renal cell carcinoma: ETS1
hsa04014__58 59	6.54970416881973e-07	DOWN	-4.97496102824677	1.79925352824741e-06	Ras signaling pathway: STK4 STK4
hsa04950__11	6.59720645651319e-07	UP	4.97356081405363	1.80701908626652e-06	Maturity onset diabetes of the young: HNF4G
hsa05032__4	6.59720645651319e-07	DOWN	-4.97356081405363	1.80701908626652e-06	Morphine addiction: ADCY1
hsa04360__19	6.64504066014953e-07	DOWN	-4.97216059986048	1.81747181956637e-06	Axon guidance: CDC42
hsa05210__22	7.03993324605775e-07	DOWN	-4.96095888631532	1.92267944321839e-06	Colorectal cancer: MYC
hsa04915__21	7.09085653362179e-07	DOWN	-4.95955867212217	1.93377640445215e-06	Estrogen signaling pathway: CREB3
hsa04932__31 133	7.14210849639297e-07	DOWN	-4.95815845792902	1.94493070503223e-06	Non-alcoholic fatty liver disease (NAFLD): PPARA RXRA
hsa04390__95	7.24576478148145e-07	DOWN	-4.95535802954273	1.97030275316985e-06	Hippo signaling pathway: AFP
hsa04720__32	7.95553268388409e-07	DOWN	-4.93715524503184	2.16018004523384e-06	Long-term potentiation: ITPR1
hsa04621__21 30	8.18707901568412e-07	DOWN	-4.93155438825926	2.21984436803326e-06	NOD-like receptor signaling pathway: NLRP3 PYCARD
hsa04919__43	8.24597196233595e-07	DOWN	-4.93015417406611	2.23259096790047e-06	Thyroid hormone signaling pathway: TBC1D4
hsa05220__6	8.30527281132013e-07	UP	4.92875395987296	2.24541116726195e-06	Chronic myeloid leukemia: TP53
hsa04750__51	8.36491513195165e-07	UP	4.92735374567982	2.25504670486903e-06	Inflammatory mediator regulation of TRP channels: TRPV4
hsa04750__61	8.36491513195165e-07	UP	4.92735374567982	2.25504670486903e-06	Inflammatory mediator regulation of TRP channels: TRPV4*
hsa05200__146 147	8.42503946838338e-07	DOWN	-4.92595353148667	2.25831382808785e-06	Pathways in cancer: RARB RXRA
hsa05222__14 15	8.42503946838338e-07	DOWN	-4.92595353148667	2.25831382808785e-06	Small cell lung cancer: RXRA RARB
hsa05223__29 34	8.42503946838338e-07	DOWN	-4.92595353148667	2.25831382808785e-06	Non-small cell lung cancer: RARB RXRA
hsa04211__51	8.42510906593712e-07	UP	4.92595353148667	2.25831382808785e-06	Longevity regulating pathway - mammal: NFKB1
hsa05200__188	8.73202967444458e-07	DOWN	-4.91895246052094	2.33724839861558e-06	Pathways in cancer: KLK3
hsa04022__63	8.85778860091507e-07	DOWN	-4.91615203213465	2.36082053632899e-06	cGMP-PKG signaling pathway: C00575
hsa04662__16	8.85778860091507e-07	UP	4.91615203213465	2.36082053632899e-06	B cell receptor signaling pathway: VAV3
hsa04914__23	8.85778860091507e-07	DOWN	-4.91615203213465	2.36082053632899e-06	Progesterone-mediated oocyte maturation: PRKACA
hsa04360__125	8.98529061413263e-07	DOWN	-4.91335160374836	2.39141091557439e-06	Axon guidance: ENAH*
hsa05132__8	9.17986263419881e-07	DOWN	-4.90915096116892	2.43974001268169e-06	Salmonella infection: TJP1
hsa04012__65	9.24561677894589e-07	DOWN	-4.90775074697578	2.4537449050338e-06	ErbB signaling pathway: MYC
hsa05200__193	9.37848810496412e-07	DOWN	-4.90495031858949	2.48549776434804e-06	Pathways in cancer: NOS2
hsa04919__102	9.44561129495701e-07	DOWN	-4.90355010439634	2.49976107369355e-06	Thyroid hormone signaling pathway: BMP4
hsa04024__31	9.58124789274293e-07	DOWN	-4.90074967601005	2.52853438068314e-06	cAMP signaling pathway: C00165
hsa04024__32	9.58124789274293e-07	DOWN	-4.90074967601005	2.52853438068314e-06	cAMP signaling pathway: C01245
hsa04064__129	9.78822439963206e-07	DOWN	-4.89654903343061	2.57953347081468e-06	NF-kappa B signaling pathway: PTGS2
hsa05205__451	1.01427845051018e-06	DOWN	-4.88954796246488	2.66688366461075e-06	Proteoglycans in cancer: KDR**
hsa04520__58	1.01480671644315e-06	UP	4.87554582053343	2.66688366461075e-06	Adherens junction: CDH1*
hsa04360__59	1.02151650237773e-06	UP	4.88814774827174	2.68076746922871e-06	Axon guidance: MAPK1*
hsa04720__4 15	1.13623853150072e-06	DOWN	-4.86714453537455	2.97767392006953e-06	Long-term potentiation: CREBBP ATF4
hsa04722__73 77	1.16886591495464e-06	DOWN	-4.86154367860197	3.05891233175456e-06	Neurotrophin signaling pathway: NGFRAP1 YWHAE
hsa05200__203	1.18551581351585e-06	UP	4.85874325021568	3.09816997718537e-06	Pathways in cancer: TGFA*
hsa04921__23	1.24560616598268e-06	DOWN	-4.84894175086366	3.25068609150203e-06	Oxytocin signaling pathway: C00219
hsa05205__431	1.25442612116311e-06	DOWN	-4.84754153667051	3.26916322006309e-06	Proteoglycans in cancer: CDKN1A*
hsa05218__8	1.29943468120055e-06	UP	4.84054046570478	3.3817697589693e-06	Melanoma: CDK4
hsa05133__24	1.32718115748486e-06	DOWN	-4.83633982312535	3.44443839076525e-06	Pertussis: NFKB1
hsa05211__43	1.32718115748486e-06	DOWN	-4.83633982312535	3.44443839076525e-06	Renal cell carcinoma: RAP1A
hsa04919__29	1.34599443996103e-06	DOWN	-4.83353939473905	3.48844627956797e-06	Thyroid hormone signaling pathway: HIF1A
hsa04152__52	1.35549700457017e-06	UP	4.83213918054591	3.50823536031316e-06	AMPK signaling pathway: PCK1
hsa04213__52	1.41388171500089e-06	DOWN	-4.82373789538703	3.65431051236131e-06	Longevity regulating pathway - multiple species: SOD2
hsa04971__56	1.42384469165353e-06	DOWN	-4.82233768119389	3.66996457560629e-06	Gastric acid secretion: CAMK2A
hsa05321__95	1.42384469165353e-06	DOWN	-4.82233768119389	3.66996457560629e-06	Inflammatory bowel disease (IBD): SMAD2
hsa04970__12	1.54872313043821e-06	UP	4.80553511087614	3.98637090697725e-06	Salivary secretion: BEST2
hsa04540__10	1.58163815923341e-06	DOWN	-4.8013344682967	4.06552407824841e-06	Gap junction: C00533
hsa04151__33	1.68424433405259e-06	UP	4.78873254055839	4.31745580311708e-06	PI3K-Akt signaling pathway: TP53
hsa04920__16	1.68424433405259e-06	DOWN	-4.78873254055839	4.31745580311708e-06	Adipocytokine signaling pathway: POMC
hsa04380__72	1.75617084766325e-06	DOWN	-4.78033125539952	4.48958506497858e-06	Osteoclast differentiation: MAPK1
hsa05030__80 81	1.75617084766325e-06	DOWN	-4.78033125539952	4.48958506497858e-06	Cocaine addiction: GRIN3A DLG4
hsa05211__40	1.78079562906298e-06	UP	4.77753082701323	4.54635188452355e-06	Renal cell carcinoma: PAK4
hsa04115__49	1.79323211282779e-06	UP	4.77613061282008	4.57189028494357e-06	p53 signaling pathway: MDM2*
hsa04750__62	1.83103721476757e-06	UP	4.77192997024064	4.65565939445182e-06	Inflammatory mediator regulation of TRP channels: TRPM8*
hsa03460__16 34	1.8310443281e-06	UP	4.77192997024064	4.65565939445182e-06	Fanconi anemia pathway: FANCM STRA13
hsa05200__219	1.86962202880602e-06	DOWN	-4.7677293276612	4.74732404341421e-06	Pathways in cancer: MYC**
hsa04380__38	1.9089800172431e-06	UP	4.76352868508177	4.84071990877164e-06	Osteoclast differentiation: FOS
hsa04151__5	1.93565960195893e-06	UP	4.76072825669548	4.90175794080975e-06	PI3K-Akt signaling pathway: EIF4B
hsa05134__68	1.96269720939296e-06	UP	4.75792782830919	4.96353708808799e-06	Legionellosis: TNF
hsa04915__66	2.00393496802556e-06	DOWN	-4.75372718572975	5.06101317865594e-06	Estrogen signaling pathway: AKT3*
hsa04024__110	2.01786490643608e-06	DOWN	-4.7523269715366	5.08935323381664e-06	cAMP signaling pathway: FOS
hsa04068__45	2.10341818892059e-06	DOWN	-4.74392568637773	5.29801980828657e-06	FoxO signaling pathway: RBL2
hsa04971__37	2.14749078341851e-06	DOWN	-4.73972504379829	5.40178739229369e-06	Gastric acid secretion: KCNQ1
hsa04668__102	2.28509375094134e-06	UP	4.72712311605998	5.74022882088072e-06	TNF signaling pathway: AKT3
hsa04210__107	2.34893257299256e-06	DOWN	-4.7215222592874	5.89271602757413e-06	Apoptosis: MCL1
hsa04610__23	2.39793179843929e-06	UP	4.71732161670796	6.00761846568991e-06	Complement and coagulation cascades: BDKRB1
hsa04014__61	2.46479253714376e-06	DOWN	-4.71172075993538	6.16690436390562e-06	Ras signaling pathway: RAP1A
hsa04950__5	2.55088765667044e-06	DOWN	-4.70471968896965	6.37382700383479e-06	Maturity onset diabetes of the young: GCK
hsa04914__42	2.60392253965569e-06	DOWN	-4.70051904639021	6.49770312352328e-06	Progesterone-mediated oocyte maturation: ARAF
hsa04960__27	2.6398653557728e-06	DOWN	-4.69771861800392	6.57865650331179e-06	Aldosterone-regulated sodium reabsorption: KCNJ1
hsa04919__28	2.65801485320073e-06	DOWN	-4.69631840381077	6.6151124624691e-06	Thyroid hormone signaling pathway: RCAN1
hsa05200__80	2.6946737729969e-06	UP	4.69351797542448	6.69747621621848e-06	Pathways in cancer: TP53
hsa04914__29	2.86571172099176e-06	UP	4.68091604768617	7.11317347918561e-06	Progesterone-mediated oocyte maturation: CDK2
hsa04713__14	2.88536608205866e-06	DOWN	-4.67951583349302	7.15251038019554e-06	Circadian entrainment: PRKCA
hsa04210__63	3.00592663326877e-06	DOWN	-4.67111454833415	7.44154959672203e-06	Apoptosis: FAS*
hsa05120__52	3.0471766482666e-06	DOWN	-4.66831411994786	7.53374331854336e-06	Epithelial cell signaling in Helicobacter pylori infection: LYN
hsa05110__46	3.1313116803283e-06	DOWN	-4.66271326317528	7.73158297941771e-06	Vibrio cholerae infection: PLCG1
hsa04910__24	3.28393751547206e-06	DOWN	-4.65291176382326	8.09779342725985e-06	Insulin signaling pathway: ACACA
hsa04725__43	3.37432929682138e-06	DOWN	-4.64731090705067	8.30978341903981e-06	Cholinergic synapse: CREB3
hsa04530__4 37 11	3.3972973216521e-06	UP	4.64591069285753	8.3444727678226e-06	Tight junction: OCLN TJP3 TJP1
hsa04730__20	3.3972973216521e-06	DOWN	-4.64591069285753	8.3444727678226e-06	Long-term depression: C00025
hsa04530__20 37	3.42041522404292e-06	UP	4.64451047866438	8.39028747516534e-06	Tight junction: ACTB TJP3
hsa04261__20	3.44368393639736e-06	DOWN	-4.64311026447124	8.43635217273878e-06	Adrenergic signaling in cardiomyocytes: ATP1B4
hsa05211__49	3.56232266769333e-06	UP	4.63610919350551	8.7156305893174e-06	Renal cell carcinoma: TGFA*
hsa03320__31	3.63537650785324e-06	DOWN	-4.63190855092607	8.88279903544375e-06	PPAR signaling pathway: CD36
hsa04972__39	3.66004538382563e-06	DOWN	-4.63050833673292	8.9314613976732e-06	Pancreatic secretion: KCNMA1*
hsa04151__73	4.13250717824206e-06	DOWN	-4.6053044812563	1.00713112683746e-05	PI3K-Akt signaling pathway: MAPK1
hsa04610__11	4.21672863963625e-06	UP	4.60110383867686	1.02632553288556e-05	Complement and coagulation cascades: F2R
hsa04066__51	4.33158554370976e-06	DOWN	-4.59550298190428	1.05291710693799e-05	HIF-1 signaling pathway: TFRC
hsa05152__9	4.50950812176374e-06	DOWN	-4.58710169674541	1.09333751752181e-05	Tuberculosis: TCIRG1
hsa05205__256	4.50950812176374e-06	DOWN	-4.58710169674541	1.09333751752181e-05	Proteoglycans in cancer: ACTB
hsa05166__39	4.5398344731712e-06	UP	4.58570148255226	1.0992717751403e-05	HTLV-I infection: RRAS2
hsa05120__53	4.78957833054839e-06	DOWN	-4.57449976900709	1.15825195406698e-05	Epithelial cell signaling in Helicobacter pylori infection: GIT1
hsa04390__52	4.88658249545215e-06	DOWN	-4.57029912642766	1.18019132505843e-05	Hippo signaling pathway: ITGB2
hsa05205__22	5.05245097678519e-06	DOWN	-4.56329805546193	1.21868490184588e-05	Proteoglycans in cancer: PPP1R12A
hsa04931__87	5.08626548970442e-06	DOWN	-4.56189784126878	1.22526831476341e-05	Insulin resistance: C00031*
hsa04930__15	5.12029665528216e-06	UP	4.56049762707564	1.23188699299298e-05	Type II diabetes mellitus: C00031*
hsa04062__40	5.18901423587427e-06	DOWN	-4.55769719868935	1.24523087473918e-05	Chemokine signaling pathway: PRKACA
hsa05219__27	5.18901423587427e-06	DOWN	-4.55769719868935	1.24523087473918e-05	Bladder cancer: RPS6KA5
hsa04668__116	5.32910786311982e-06	UP	4.55209634191676	1.27721858096966e-05	TNF signaling pathway: PGAM5
hsa04722__35	5.47281861570621e-06	DOWN	-4.54649548514418	1.30999059603974e-05	Neurotrophin signaling pathway: FOXO3
hsa04670__14	5.73328429298135e-06	UP	4.53669398579216	1.37059048174452e-05	Leukocyte transendothelial migration: SIPA1
hsa04520__7 68	6.08563929605691e-06	UP	4.52409205805385	1.45297537957953e-05	Adherens junction: CDH1 CTNNB1
hsa05221__21	6.20762843405975e-06	DOWN	-4.51989141547441	1.48022002888303e-05	Acute myeloid leukemia: PIM1
hsa05216__14	6.33195547088365e-06	UP	4.51569077289497	1.5079523865387e-05	Thyroid cancer: MAPK1*
hsa04213__55	6.45866297609778e-06	DOWN	-4.51149013031554	1.53618072558073e-05	Longevity regulating pathway - multiple species: CRYAB
hsa04664__46	6.76381581677667e-06	DOWN	-4.50168863096352	1.60469822218729e-05	Fc epsilon RI signaling pathway: PLA2G4B
hsa04919__103	6.76381581677667e-06	DOWN	-4.50168863096352	1.60469822218729e-05	Thyroid hormone signaling pathway: CCND1
hsa05210__39	6.80851915060196e-06	UP	4.50028841677037	1.61326702193961e-05	Colorectal cancer: BAD
hsa04066__30	6.85350502181578e-06	DOWN	-4.49888820257723	1.62188110025086e-05	HIF-1 signaling pathway: PDK1
hsa04921__41	7.12944923898835e-06	DOWN	-4.49048691741835	1.68506102139108e-05	Oxytocin signaling pathway: PTGS2
hsa04360__131	7.97018760183936e-06	UP	4.46668327613487	1.87904422884017e-05	Axon guidance: RAC1****
hsa04370__28	7.97018760183936e-06	DOWN	-4.46668327613487	1.87904422884017e-05	VEGF signaling pathway: SHC2
hsa04976__41	8.02246905640148e-06	DOWN	-4.46528306194173	1.88899991942085e-05	Bile secretion: CYP7A1
hsa04920__40	8.07511275952444e-06	DOWN	-4.46388284774858	1.89901587924236e-05	Adipocytokine signaling pathway: PPARGC1A
hsa04115__2	8.12806923416963e-06	UP	4.46248263355544	1.90908026137559e-05	p53 signaling pathway: IGFBP3
hsa04014__104	8.23497979388121e-06	UP	4.45968220516914	1.93177615888924e-05	Ras signaling pathway: BRAP*
hsa04742__67	8.28893783951269e-06	DOWN	-4.458281990976	1.94200925192573e-05	Taste transduction: PRKACA
hsa05160__15 16	8.50816851977254e-06	DOWN	-4.45268113420342	1.99089024267156e-05	Hepatitis C: TRAF6 RIPK1
hsa04932__56	8.79000621820414e-06	UP	4.44568006323769	2.05428130398079e-05	Non-alcoholic fatty liver disease (NAFLD): CASP7
hsa04064__113	8.90522090961499e-06	DOWN	-4.4428796348514	2.07862237132504e-05	NF-kappa B signaling pathway: CFLAR
hsa04933__78	9.02187782352397e-06	DOWN	-4.4400792064651	2.10323925935503e-05	AGE-RAGE signaling pathway in diabetic complications: TGFB1
hsa05161__194	1.01395800409086e-05	UP	4.41487535098848	2.36087619539866e-05	Hepatitis B: TNF*
hsa05222__35	1.05406838041471e-05	DOWN	-4.40647406582961	2.45123080049411e-05	Small cell lung cancer: NOS2
hsa04360__29	1.09569121844342e-05	UP	4.39807278067073	2.54173308574714e-05	Axon guidance: RASA1
hsa04727__47	1.09569121844342e-05	DOWN	-4.39807278067073	2.54173308574714e-05	GABAergic synapse: CACNA1A*
hsa04066__61	1.10991087922318e-05	DOWN	-4.39527235228444	2.57154444150474e-05	HIF-1 signaling pathway: HMOX1
hsa04064__4	1.12430661801792e-05	DOWN	-4.39247192389815	2.59848971126158e-05	NF-kappa B signaling pathway: BIRC2
hsa04064__116	1.12430661801792e-05	DOWN	-4.39247192389815	2.59848971126158e-05	NF-kappa B signaling pathway: GADD45B
hsa04668__38	1.21449599266809e-05	UP	4.3756693535804	2.80004658923108e-05	TNF signaling pathway: CEBPB
hsa04722__46	1.21449599266809e-05	DOWN	-4.3756693535804	2.80004658923108e-05	Neurotrophin signaling pathway: ATF4*
hsa04961__13	1.22231568775118e-05	DOWN	-4.37426913938726	2.81462154078978e-05	Endocrine and other factor-regulated calcium reabsorption: ATP2B1
hsa04724__51	1.24606409796963e-05	UP	4.37006849680782	2.8657949083047e-05	Glutamatergic synapse: ADRBK1
hsa04620__22	1.34553457466499e-05	UP	4.35326592649007	3.09078174302631e-05	Toll-like receptor signaling pathway: CD86
hsa04620__39	1.3541572311047e-05	DOWN	-4.35186571229692	3.10300175273869e-05	Toll-like receptor signaling pathway: IL6
hsa05034__99	1.3541572311047e-05	DOWN	-4.35186571229692	3.10300175273869e-05	Alcoholism: PDYN
hsa04340__40	1.47115961883643e-05	DOWN	-4.33366292778603	3.36700234323222e-05	Hedgehog signaling pathway: SUFU
hsa05161__48	1.49949750609111e-05	DOWN	-4.32946228520659	3.42768347195279e-05	Hepatitis B: STAT1
hsa04390__17 51	1.51867776410896e-05	DOWN	-4.3266618568203	3.46310135771933e-05	Hippo signaling pathway: YWHAQ YAP1
hsa05215__12	1.51867776410896e-05	DOWN	-4.3266618568203	3.46310135771933e-05	Prostate cancer: KLK3
hsa04014__76	1.54788731687217e-05	DOWN	-4.32246121424086	3.52543062836703e-05	Ras signaling pathway: RALBP1*
hsa04014__44	1.59776362500686e-05	DOWN	-4.31546014327513	3.6302271479902e-05	Ras signaling pathway: ETS1
hsa04922__59	1.59776362500686e-05	DOWN	-4.31546014327513	3.6302271479902e-05	Glucagon signaling pathway: CPT1C
hsa04064__115	1.60792104259222e-05	DOWN	-4.31405992908199	3.6488932838536e-05	NF-kappa B signaling pathway: XIAP
hsa05161__97	1.63876390348886e-05	DOWN	-4.30985928650255	3.71439972817317e-05	Hepatitis B: BCL2
hsa04213__54	1.7021494815872e-05	UP	4.30145800134368	3.85342033241246e-05	Longevity regulating pathway - multiple species: SOD2*
hsa04510__19 26	1.72379230669495e-05	DOWN	-4.29865757295739	3.89772051056537e-05	Focal adhesion: VCL ACTN4
hsa05211__22	1.79030522910078e-05	UP	4.29025628779851	4.03355338786614e-05	Renal cell carcinoma: TGFA
hsa05214__23	1.79030522910078e-05	DOWN	-4.29025628779851	4.03355338786614e-05	Glioma: MAPK1
hsa05214__56	1.79030522910078e-05	DOWN	-4.29025628779851	4.03355338786614e-05	Glioma: MAPK1*
hsa04921__43	1.81301445793086e-05	DOWN	-4.28745585941222	4.07982534904442e-05	Oxytocin signaling pathway: CACNG3
hsa04722__85	1.8244717255407e-05	DOWN	-4.28605564521907	4.10069661757293e-05	Neurotrophin signaling pathway: BAX
hsa04916__4	1.83599794817963e-05	DOWN	-4.28465543102593	4.12167281317746e-05	Melanogenesis: TYR
hsa04919__27	1.87099427940117e-05	DOWN	-4.28045478844649	4.19522464319189e-05	Thyroid hormone signaling pathway: GATA4
hsa04912__46	1.90662545333797e-05	DOWN	-4.27625414586705	4.27002291635524e-05	GnRH signaling pathway: JUN
hsa04510__6 4 5	1.930737623465e-05	DOWN	-4.27345371748076	4.31374077822917e-05	Focal adhesion: FLNA ITGB1 ITGA11
hsa04510__26 4 5	1.930737623465e-05	DOWN	-4.27345371748076	4.31374077822917e-05	Focal adhesion: ACTN4 ITGB1 ITGA11
hsa05140__26	1.9551400415745e-05	DOWN	-4.27065328909447	4.36307379824049e-05	Leishmaniasis: C00533
hsa04010__134	2.08162259191033e-05	UP	4.25665114716301	4.63432328222692e-05	MAPK signaling pathway: ATF4*
hsa04550__69	2.08162259191033e-05	DOWN	-4.25665114716301	4.63432328222692e-05	Signaling pathways regulating pluripotency of stem cells: ID1
hsa04066__55	2.12106183038141e-05	DOWN	-4.25245050458358	4.71653867371204e-05	HIF-1 signaling pathway: ANGPT1
hsa05211__31	2.16121178373146e-05	DOWN	-4.24824986200414	4.80013822887874e-05	Renal cell carcinoma: SOS1
hsa04666__20	2.24369237178396e-05	UP	4.23984857684527	4.9774474221748e-05	Fc gamma R-mediated phagocytosis: PLA2G4B
hsa04660__14	2.27184545609668e-05	DOWN	-4.23704814845897	5.03395944811988e-05	T cell receptor signaling pathway: NFKB1
hsa04919__38	2.28604775725296e-05	DOWN	-4.23564793426583	5.0594625864291e-05	Thyroid hormone signaling pathway: TP53
hsa05161__214	2.35833579616174e-05	DOWN	-4.2286468633001	5.21330936586814e-05	Hepatitis B: CDKN1B
hsa04360__117	2.37305206483448e-05	DOWN	-4.22724664910695	5.23352679556807e-05	Axon guidance: CFL1*
hsa05169__32	2.37305206483448e-05	UP	4.22724664910695	5.23352679556807e-05	Epstein-Barr virus infection: CR2
hsa04024__111	2.38785568362495e-05	DOWN	-4.22584643491381	5.26000097248685e-05	cAMP signaling pathway: JUN
hsa04010__87	2.40274714181366e-05	UP	4.22444622072066	5.28660641623871e-05	MAPK signaling pathway: STK3
hsa05100__15	2.43279554630901e-05	UP	4.22164579233437	5.34645945206389e-05	Bacterial invasion of epithelial cells: CTNNA1
hsa04151__36	2.44795348401466e-05	UP	4.22024557814123	5.37348667811161e-05	PI3K-Akt signaling pathway: PCK1
hsa04066__52	2.47853932828138e-05	DOWN	-4.21744514975493	5.42162444451771e-05	HIF-1 signaling pathway: FLT1
hsa04726__39	2.47853932828138e-05	DOWN	-4.21744514975493	5.42162444451771e-05	Serotonergic synapse: CACNA1C
hsa05200__192	2.47853932828138e-05	DOWN	-4.21744514975493	5.42162444451771e-05	Pathways in cancer: PTGS2
hsa04064__51	2.5251005890788e-05	DOWN	-4.2132445071755	5.51705117078961e-05	NF-kappa B signaling pathway: TNFAIP3
hsa04261__23	2.55660237700449e-05	DOWN	-4.21044407878921	5.57939125016427e-05	Adrenergic signaling in cardiomyocytes: SLC9A1
hsa05200__210	2.5724931014511e-05	DOWN	-4.20904386459606	5.60755746824434e-05	Pathways in cancer: MMP1
hsa04152__68	2.60455681530124e-05	DOWN	-4.20624343620977	5.67087167549366e-05	AMPK signaling pathway: PPARGC1A**
hsa04912__15	2.62073085443393e-05	DOWN	-4.20484322201662	5.69948295773306e-05	GnRH signaling pathway: CAMK2A
hsa04668__36	2.65336594192639e-05	UP	4.20204279363033	5.76378567038114e-05	TNF signaling pathway: CREB3
hsa03320__45	2.71979913851665e-05	DOWN	-4.19644193685775	5.9012731885367e-05	PPAR signaling pathway: PDPK1
hsa04015__18	2.83987951245719e-05	DOWN	-4.18664043750573	6.15471003910848e-05	Rap1 signaling pathway: CDH1
hsa04014__42	2.92871885588424e-05	DOWN	-4.17963936654	6.33993402097522e-05	Ras signaling pathway: PLA2G4B
hsa05200__184	2.98328381786715e-05	DOWN	-4.17543872396056	6.45062174197052e-05	Pathways in cancer: GLI1
hsa05200__186	3.0201957611819e-05	DOWN	-4.17263829557427	6.52292854627676e-05	Pathways in cancer: PTCH1*
hsa05205__129	3.09532578579712e-05	DOWN	-4.16703743880169	6.66985911870734e-05	Proteoglycans in cancer: AKT3*
hsa05211__46	3.09532578579712e-05	DOWN	-4.16703743880169	6.66985911870734e-05	Renal cell carcinoma: AKT3
hsa04066__60	3.29099753641566e-05	DOWN	-4.15303529687023	7.08337270438147e-05	HIF-1 signaling pathway: NOS3
hsa04115__17	3.31119836714633e-05	UP	4.15163508267708	7.11869763371619e-05	p53 signaling pathway: TP73
hsa04725__18	3.37250996643585e-05	DOWN	-4.14743444009765	7.24222425935196e-05	Cholinergic synapse: ITPR1
hsa04210__58	3.45593769480541e-05	UP	4.14183358332506	7.40445487860817e-05	Apoptosis: BID*
hsa05215__8	3.45593769480541e-05	DOWN	-4.14183358332506	7.40445487860817e-05	Prostate cancer: NFKBIA
hsa05010__47	3.4770988332866e-05	DOWN	-4.14043336913192	7.44130832317257e-05	Alzheimer's disease: C00533
hsa04550__53 64	3.49838298875803e-05	DOWN	-4.13903315493877	7.47834088268071e-05	Signaling pathways regulating pluripotency of stem cells: SMAD1 SMAD4
hsa04622__9 35	3.54132304676895e-05	UP	4.13623272655248	7.5615295509987e-05	RIG-I-like receptor signaling pathway: IRF3 PIN1
hsa04014__97	3.58476329538423e-05	DOWN	-4.13343229816619	7.64559617710212e-05	Ras signaling pathway: PAK4
hsa04010__15	3.71814028321538e-05	DOWN	-4.12503101300732	7.91210146337679e-05	MAPK signaling pathway: NFKB1
hsa04810__31	3.71814028321538e-05	DOWN	-4.12503101300732	7.91210146337679e-05	Regulation of actin cytoskeleton: MSN
hsa04064__50	3.76363667386107e-05	DOWN	-4.12223058462102	7.990817299644e-05	NF-kappa B signaling pathway: NFKBIA*
hsa05200__195	3.76363667386107e-05	DOWN	-4.12223058462102	7.990817299644e-05	Pathways in cancer: BIRC8
hsa05211__2	3.83287336606466e-05	DOWN	-4.11802994204159	8.12863324473531e-05	Renal cell carcinoma: TGFB1
hsa04611__7	3.85621971190836e-05	DOWN	-4.11662972784844	8.16892541000656e-05	Platelet activation: ITPR1
hsa03320__25	3.99915728524836e-05	DOWN	-4.10822844268957	8.46218078714151e-05	PPAR signaling pathway: EHHADH
hsa04068__51	4.02346373116631e-05	DOWN	-4.10682822849642	8.4944812931028e-05	FoxO signaling pathway: BCL6
hsa04068__56	4.02346373116631e-05	DOWN	-4.10682822849642	8.4944812931028e-05	FoxO signaling pathway: BCL6*
hsa05205__238	4.14711348742841e-05	DOWN	-4.09982715753069	8.74570846563186e-05	Proteoglycans in cancer: ITGAV*
hsa04261__73	4.17227231716515e-05	DOWN	-4.09842694333755	8.78890099097904e-05	Adrenergic signaling in cardiomyocytes: KCNE1
hsa04151__34	4.19757591549862e-05	UP	4.0970267291444	8.83230139442543e-05	PI3K-Akt signaling pathway: GYS1
hsa04664__25	4.22302506555872e-05	DOWN	-4.09562651495126	8.87591062436783e-05	Fc epsilon RI signaling pathway: MAPK14
hsa04971__39	4.32629298367264e-05	DOWN	-4.09002565817867	9.08279834225798e-05	Gastric acid secretion: EZR
hsa04064__94	4.37882090519726e-05	DOWN	-4.08722522979238	9.15217406102964e-05	NF-kappa B signaling pathway: BCL2L1*
hsa04723__40	4.37882090519726e-05	DOWN	-4.08722522979238	9.15217406102964e-05	Retrograde endocannabinoid signaling: GRIA1
hsa04724__4	4.37882090519726e-05	DOWN	-4.08722522979238	9.15217406102964e-05	Glutamatergic synapse: GRIA1
hsa05031__12	4.37882090519726e-05	DOWN	-4.08722522979238	9.15217406102964e-05	Amphetamine addiction: GRIA1
hsa04064__25	4.43195340979379e-05	UP	4.08442480140609	9.25293384111393e-05	NF-kappa B signaling pathway: NFKB2
hsa04668__47	4.59504412153093e-05	UP	4.07602351624722	9.58278346765439e-05	TNF signaling pathway: CASP7
hsa05205__233 234	4.62277324029932e-05	DOWN	-4.07462330205407	9.62992341299603e-05	Proteoglycans in cancer: ITGA2 C00925
hsa04390__90	4.65066098806731e-05	UP	4.07322308786092	9.6772890327558e-05	Hippo signaling pathway: BBC3
hsa04310__20	4.76381538244758e-05	DOWN	-4.06762223108834	9.90177998187943e-05	Wnt signaling pathway: MAPK8
hsa05210__31	4.96814259716063e-05	DOWN	-4.05782073173632	0.000103150717569777	Colorectal cancer: BCL2
hsa05205__352	5.05822890615425e-05	DOWN	-4.05362008915688	0.000104905210978629	Proteoglycans in cancer: ITGA5*
hsa04066__53	5.27449499150694e-05	DOWN	-4.04381858980486	0.000109269857652057	HIF-1 signaling pathway: EGF*
hsa04913__36	5.33787625206776e-05	DOWN	-4.04101816141857	0.00011033959821381	Ovarian steroidogenesis: CYP19A1
hsa04913__37	5.33787625206776e-05	DOWN	-4.04101816141857	0.00011033959821381	Ovarian steroidogenesis: CYP19A1*
hsa04650__15	5.36983685557644e-05	UP	4.03961794722543	0.000110878279688221	Natural killer cell mediated cytotoxicity: TNF
hsa04660__35	5.46681009194453e-05	DOWN	-4.03541730464599	0.000112756708702127	T cell receptor signaling pathway: NFATC1
hsa04510__19 23	5.53237814346046e-05	DOWN	-4.0326168762597	0.000113983975126779	Focal adhesion: VCL TLN1
hsa05031__55	5.56544087424822e-05	DOWN	-4.03121666206655	0.000114539577247672	Amphetamine addiction: GRIA1*
hsa04014__79	5.59869072490298e-05	DOWN	-4.02981644787341	0.000115097810416769	Ras signaling pathway: RAC1**
hsa04066__62	5.66575576451025e-05	DOWN	-4.02701601948711	0.000116349235863549	HIF-1 signaling pathway: NPPA
hsa05205__337	5.83676310362288e-05	DOWN	-4.02001494852139	0.000119730107769731	Proteoglycans in cancer: CTNNB1**
hsa04530__8	6.15696241870531e-05	UP	4.00741302078307	0.000126160658503242	Tight junction: LLGL2
hsa04310__31	6.30454911067826e-05	DOWN	-4.00181216401049	0.000128903675505598	Wnt signaling pathway: MMP7
hsa05132__41	6.30454911067826e-05	DOWN	-4.00181216401049	0.000128903675505598	Salmonella infection: ACTB*
hsa04950__1	6.45548049759938e-05	UP	3.99621130723791	0.00013184617233684	Maturity onset diabetes of the young: HNF1B
hsa04390__74	6.53222257192211e-05	DOWN	-3.99341087885162	0.000133268688519453	Hippo signaling pathway: AXIN1
hsa04261__14 16	6.60982753701186e-05	UP	3.99061045046533	0.000134705704360578	Adrenergic signaling in cardiomyocytes: TNNI3 TPM1
hsa04922__78	6.64895643981692e-05	DOWN	-3.98921023627218	0.000135356328823575	Glucagon signaling pathway: ACACA
hsa05120__50	6.72787280662331e-05	DOWN	-3.98640980788589	0.000136814642896593	Epithelial cell signaling in Helicobacter pylori infection: EGFR
hsa04742__27	6.7676625755473e-05	DOWN	-3.98500959369274	0.00013747500518328	Taste transduction: CALHM1
hsa04340__15	6.8076749474082e-05	UP	3.9836093794996	0.000138138458166091	Hedgehog signaling pathway: HHIP
hsa04660__40 41	6.96997387822043e-05	DOWN	-3.97800852272701	0.000141279190045051	T cell receptor signaling pathway: LAT GRAP2
hsa04660__41 46	7.01111687490566e-05	DOWN	-3.97660830853387	0.000141807197071558	T cell receptor signaling pathway: GRAP2 LCP2
hsa05220__21	7.01111687490566e-05	DOWN	-3.97660830853387	0.000141807197071558	Chronic myeloid leukemia: NFKBIA
hsa04913__40	7.09409312949997e-05	DOWN	-3.97380788014758	0.000143331193444413	Ovarian steroidogenesis: HSD17B1
hsa04925__34	7.13592879458713e-05	DOWN	-3.97240766595443	0.000143712863933861	Aldosterone synthesis and secretion: STAR
hsa04971__52 53	7.13592879458713e-05	DOWN	-3.97240766595443	0.000143712863933861	Gastric acid secretion: EZR ACTB
hsa05205__140	7.13592879458713e-05	DOWN	-3.97240766595443	0.000143712863933861	Proteoglycans in cancer: MAPK1***
hsa05219__19	7.34863116602008e-05	DOWN	-3.9654065949887	0.00014783809380034	Bladder cancer: TP53
hsa04064__131	7.39188505901678e-05	DOWN	-3.96400638079556	0.000148549219528262	NF-kappa B signaling pathway: CCL4L1
hsa05205__188	7.56732023605158e-05	UP	3.95840552402297	0.000151912336789967	Proteoglycans in cancer: TNF
hsa04931__67	7.65647094387482e-05	DOWN	-3.95560509563668	0.000153537981894779	Insulin resistance: IKBKB**
hsa04210__106	7.70145699058969e-05	DOWN	-3.95420488144354	0.000154275455067356	Apoptosis: TUBA1B
hsa04976__37	8.11744347983536e-05	DOWN	-3.94160295370523	0.000162435317344096	Bile secretion: ABCB11
hsa04152__60	8.5051508190897e-05	UP	3.93040124016006	0.000169831863858337	AMPK signaling pathway: EEF2
hsa04722__70	8.5051508190897e-05	UP	3.93040124016006	0.000169831863858337	Neurotrophin signaling pathway: ZNF274
hsa04115__29	8.6047483300631e-05	DOWN	-3.92760081177377	0.000171456226004121	p53 signaling pathway: IGF1
hsa04210__114	8.6047483300631e-05	DOWN	-3.92760081177377	0.000171456226004121	Apoptosis: HRK
hsa05205__236	8.96208744291456e-05	DOWN	-3.91779931242175	0.000178387312555471	Proteoglycans in cancer: ITGAV
hsa05216__12	9.11479541172246e-05	UP	3.91359866984231	0.000181136491340871	Thyroid cancer: CDH1
hsa05131__12	9.11948487538392e-05	DOWN	-3.91359866984231	0.000181136491340871	Shigellosis: ARPC5
hsa05222__36	9.22586316596965e-05	DOWN	-3.91079824145602	0.000183055933356462	Small cell lung cancer: PTGS2
hsa04014__43	9.27949077511193e-05	DOWN	-3.90939802726287	0.000183925771797841	Ras signaling pathway: ELK1
hsa03320__44	9.88915438559304e-05	DOWN	-3.89399567113827	0.000195803172713692	PPAR signaling pathway: FABP1
hsa04360__123	0.000103560891684434	DOWN	-3.8827939575931	0.000204832542605318	Axon guidance: ENAH
hsa05212__54	0.000104158979073419	DOWN	-3.88139374339996	0.000205798866118775	Pancreatic cancer: C00416
hsa04742__23 45	0.000105972237374895	UP	3.87719310082052	0.000209161590364945	Taste transduction: PKD1L3 PKD2L1
hsa04950__13	0.000109690413333064	UP	3.86879181566165	0.000216046422067954	Maturity onset diabetes of the young: INS
hsa04973__36	0.000109690413333064	DOWN	-3.86879181566165	0.000216046422067954	Carbohydrate digestion and absorption: SLC2A2
hsa05134__10	0.000111595003757411	DOWN	-3.86459117308221	0.000219567551895471	Legionellosis: NFKB1
hsa04610__58	0.000116827568869649	UP	3.85338945953704	0.000229622386931036	Complement and coagulation cascades: F2RL2
hsa04933__26	0.000118848773443902	DOWN	-3.84918881695761	0.000233350935528832	AGE-RAGE signaling pathway in diabetic complications: IL6
hsa04068__55	0.000119529803872481	DOWN	-3.84778860276446	0.000234198645960784	FoxO signaling pathway: ATM
hsa05168__27	0.000119529803872481	UP	3.84778860276446	0.000234198645960784	Herpes simplex infection: IRF3
hsa04620__87	0.000122990504228251	DOWN	-3.84078753179873	0.000240728289005087	Toll-like receptor signaling pathway: CCL4L1
hsa04210__31 32 33	0.000123693884772844	UP	3.83938731760559	0.000241853079592273	Apoptosis: TRAF2 RIPK1 TRADD
hsa04211__23	0.000125112037411111	DOWN	-3.8365868892193	0.000244371640639789	Longevity regulating pathway - mammal: SOD2
hsa04620__19	0.000125826847665555	UP	3.83518667502615	0.00024551261346166	Toll-like receptor signaling pathway: CXCL10
hsa04014__37	0.000127994444981485	DOWN	-3.83098603244671	0.000249482948257479	Ras signaling pathway: FASLG
hsa04210__10	0.000130939356387039	DOWN	-3.82538517567413	0.000254694669411229	Apoptosis: BIRC2
hsa05223__7	0.000130939356387039	DOWN	-3.82538517567413	0.000254694669411229	Non-small cell lung cancer: FOXO3
hsa04666__50 52	0.000138583421748445	DOWN	-3.81138303374267	0.000269284642673555	Fc gamma R-mediated phagocytosis: DNM2 AMPH
hsa04620__12	0.000140161840175293	DOWN	-3.80858260535638	0.000271789574498839	Toll-like receptor signaling pathway: NFKB1
hsa04750__39	0.000140161840175293	DOWN	-3.80858260535638	0.000271789574498839	Inflammatory mediator regulation of TRP channels: C01245*
hsa04310__14	0.000141757180439559	DOWN	-3.80578217697009	0.000274599734067971	Wnt signaling pathway: PRKCA
hsa04742__4	0.000144999303096876	UP	3.80018132019751	0.000280590824427426	Taste transduction: TRPM5
hsa04390__89	0.000145820675478038	DOWN	-3.79878110600436	0.000281311138832888	Hippo signaling pathway: ID2
hsa04726__41	0.000145820675478038	UP	3.79878110600436	0.000281311138832888	Serotonergic synapse: HTR3C
hsa04742__57	0.000145820675478038	UP	3.79878110600436	0.000281311138832888	Taste transduction: HTR3C
hsa04066__54	0.000148311158413239	DOWN	-3.79458046342492	0.000285529371576308	HIF-1 signaling pathway: SERPINE1
hsa05161__31	0.000148311158413239	DOWN	-3.79458046342492	0.000285529371576308	Hepatitis B: ELK1
hsa04726__38	0.000154278905768943	DOWN	-3.7847789640729	0.000296714497379574	Serotonergic synapse: PLA2G4B
hsa04933__27	0.00015867918492654	UP	3.77777789310718	0.000304865223391584	AGE-RAGE signaling pathway in diabetic complications: TNF
hsa04068__60	0.000159573297172232	DOWN	-3.77637767891403	0.000306269893142619	FoxO signaling pathway: RAG1
hsa04150__56	0.00016503832050891	DOWN	-3.76797639375516	0.000316113154165384	mTOR signaling pathway: EIF4B
hsa05142__64	0.00016503832050891	UP	3.76797639375516	0.000316113154165384	Chagas disease (American trypanosomiasis): CASP8
hsa04510__23 4 5	0.000165966103114751	DOWN	-3.76657617956201	0.000317566504839732	Focal adhesion: TLN1 ITGB1 ITGA11
hsa05010__37	0.000172599282423661	DOWN	-3.75677468020999	0.000329922738223865	Alzheimer's disease: MAPT
hsa05120__20	0.000173566986956225	UP	3.75537446601684	0.00033143533383206	Epithelial cell signaling in Helicobacter pylori infection: CXCL8
hsa04919__18	0.000177489064911616	DOWN	-3.74977360924426	0.000338580662912615	Thyroid hormone signaling pathway: STAT1
hsa04024__2	0.000178482525048315	DOWN	-3.74837339505111	0.000340130491446028	cAMP signaling pathway: CACNA1C
hsa04014__30	0.000181494369272416	DOWN	-3.74417275247168	0.000345519675646272	Ras signaling pathway: C01245
hsa05168__39 40	0.000185584537792452	UP	3.73857189569909	0.000352948731287468	Herpes simplex infection: POU2F3 HCFC2
hsa04611__92	0.000186620534656743	DOWN	-3.73717168150595	0.000354560146228533	Platelet activation: RHOA*
hsa04930__13	0.000187661965914848	UP	3.7357714673128	0.000356178620155556	Type II diabetes mellitus: C00162
hsa03320__57	0.000189761237545567	DOWN	-3.73297103892651	0.000359799561400726	PPAR signaling pathway: APOC3
hsa05200__216	0.000195106384711204	DOWN	-3.72596996796078	0.000369561387976161	Pathways in cancer: IL6
hsa05164__24	0.000199484029998537	UP	3.7203691111882	0.000377472801981119	Influenza A: IRF7
hsa04380__69	0.000206223853243657	UP	3.71196782602933	0.000389441829391791	Osteoclast differentiation: NFKB2
hsa04931__135	0.000206223853243657	UP	3.71196782602933	0.000389441829391791	Insulin resistance: SREBF1**
hsa04932__96	0.000210835271020622	DOWN	-3.70636696925674	0.000397750476152359	Non-alcoholic fatty liver disease (NAFLD): IL6*
hsa04010__78	0.000215543398228852	DOWN	-3.70076611248416	0.000406224719430304	MAPK signaling pathway: MAP3K4
hsa04530__13 45 20	0.000221567418085481	DOWN	-3.69376504151843	0.000417159497577773	Tight junction: EPB41 TJP2 ACTB
hsa04621__28	0.000222791035015434	UP	3.69236482732529	0.000419043398192192	NOD-like receptor signaling pathway: CASP8
hsa03320__47	0.000240601551887503	DOWN	-3.67276182862125	0.000451638677319299	PPAR signaling pathway: PLTP
hsa04950__15	0.000240601551887503	UP	3.67276182862125	0.000451638677319299	Maturity onset diabetes of the young: IAPP
hsa05010__50	0.000248636357381805	DOWN	-3.66436054346237	0.000466255205110191	Alzheimer's disease: ERN1
hsa04390__5	0.000265466668053629	DOWN	-3.64755797314462	0.000496824570988813	Hippo signaling pathway: SAV1
hsa05160__54	0.000265466668053629	UP	3.64755797314462	0.000496824570988813	Hepatitis C: IRF1
hsa04666__23	0.000266916368503992	UP	3.64615775895148	0.000499040653153234	Fc gamma R-mediated phagocytosis: RPS6KB1
hsa04726__16	0.000275771599550991	DOWN	-3.6377564737926	0.000514572825775882	Serotonergic synapse: ITPR1
hsa04726__46	0.000275771599550991	DOWN	-3.6377564737926	0.000514572825775882	Serotonergic synapse: ITPR1*
hsa04530__22 33	0.00027878401577729	UP	3.63495604540631	0.00051967774369596	Tight junction: MYL12B CGN
hsa04630__36	0.000291144757367851	UP	3.62375433186115	0.000542181366793055	Jak-STAT signaling pathway: GFAP
hsa04390__59	0.000292725453689229	DOWN	-3.622354117668	0.000544585274734715	Hippo signaling pathway: SERPINE1
hsa04151__99	0.000295910992696425	UP	3.61955368928171	0.000549423671221919	PI3K-Akt signaling pathway: MYB
hsa04918__10	0.000295910992696425	DOWN	-3.61955368928171	0.000549423671221919	Thyroid hormone synthesis: TG
hsa04350__34	0.000305663517077385	DOWN	-3.61115240412283	0.000565853939495968	TGF-beta signaling pathway: ROCK1
hsa05145__33	0.000305663517077385	DOWN	-3.61115240412283	0.000565853939495968	Toxoplasmosis: STAT3
hsa05169__125	0.000305663517077385	DOWN	-3.61115240412283	0.000565853939495968	Epstein-Barr virus infection: STAT3
hsa04725__61	0.00031401969454394	DOWN	-3.6041513331571	0.000580750990204786	Cholinergic synapse: FOS
hsa04015__11	0.000315716389664825	UP	3.60275111896396	0.000583314745506593	Rap1 signaling pathway: RAC1
hsa04921__60	0.00031913555734532	DOWN	-3.59995069057767	0.000589052762526382	Oxytocin signaling pathway: ELK1
hsa05321__19	0.00032432935527971	UP	3.59575004799823	0.000598051872983881	Inflammatory bowel disease (IBD): TNF
hsa04921__77	0.000336757470694404	DOWN	-3.58594854864621	0.000620360085720377	Oxytocin signaling pathway: KCNJ3
hsa04390__80	0.000345905991315005	DOWN	-3.57894747768048	0.000636588988913707	Hippo signaling pathway: BIRC2
hsa04014__63	0.000349630080808427	DOWN	-3.57614704929419	0.000642813035067548	Ras signaling pathway: TIAM1*
hsa04914__39	0.000362961802265805	DOWN	-3.56634554994217	0.000666671775618228	Progesterone-mediated oocyte maturation: PIK3R5
hsa04540__1	0.000374764970236433	DOWN	-3.5579442647833	0.000687679081127204	Gap junction: C00681
hsa04917__48	0.000378779556483382	DOWN	-3.555143836397	0.000693690825177656	Prolactin signaling pathway: CCND2
hsa05161__78	0.000378779556483382	UP	3.555143836397	0.000693690825177656	Hepatitis B: TNF
hsa04550__9	0.000386927891544777	UP	3.54954297962442	0.000707923571774719	Signaling pathways regulating pluripotency of stem cells: HNF1A
hsa04740__33	0.000388989988276858	DOWN	-3.54814276543128	0.000711004073902934	Olfactory transduction: CNGA3*
hsa04115__31	0.000397343698412342	DOWN	-3.54254190865869	0.000725567355992993	p53 signaling pathway: ADGRB1
hsa05152__129	0.000403718321962846	UP	3.53834126607926	0.000735777620725691	Tuberculosis: IFNB1
hsa05164__77	0.000403718321962846	UP	3.53834126607926	0.000735777620725691	Influenza A: CASP9
hsa04010__14	0.000410188381966672	DOWN	-3.53414062349982	0.000745400357558391	MAPK signaling pathway: MAPT
hsa05214__27	0.000410188381966672	UP	3.53414062349982	0.000745400357558391	Glioma: MTOR
hsa05214__48	0.000410188381966672	UP	3.53414062349982	0.000745400357558391	Glioma: MTOR*
hsa04210__71	0.00041675519135755	DOWN	-3.52993998092038	0.000755871626023974	Apoptosis: GADD45G
hsa04750__59	0.00041675519135755	DOWN	-3.52993998092038	0.000755871626023974	Inflammatory mediator regulation of TRP channels: TRPV2
hsa04724__26	0.000451087574927177	DOWN	-3.5089367680232	0.000817351546083091	Glutamatergic synapse: PRKACA
hsa04621__21 31 41	0.000460678877170618	DOWN	-3.50333591125061	0.000833123782679106	NOD-like receptor signaling pathway: NLRP3 CARD8 CASP1
hsa04922__51	0.000460678877170618	DOWN	-3.50333591125061	0.000833123782679106	Glucagon signaling pathway: G6PC
hsa05160__55	0.000482959321016434	UP	3.4907339835123	0.000872577465567192	Hepatitis C: MAPK14
hsa04210__56	0.000485496023448425	UP	3.48933376931916	0.000876317990451095	Apoptosis: BAX
hsa04024__3	0.000490606749166703	DOWN	-3.48653334093286	0.000884692976664333	cAMP signaling pathway: RYR2
hsa04912__43	0.000527811096173061	DOWN	-3.46693034222882	0.000950869654562973	GnRH signaling pathway: PTK2B
hsa05211__21	0.000530566710796733	DOWN	-3.46553012803568	0.000954918438301783	Renal cell carcinoma: TGFB1*
hsa04620__86	0.000541723781230231	DOWN	-3.45992927126309	0.000974066014288617	Toll-like receptor signaling pathway: IL12A
hsa04014__35	0.000550234612070508	DOWN	-3.45572862868366	0.000988423361453619	Ras signaling pathway: NFKB1
hsa04210__4	0.00055597751979833	DOWN	-3.45292820029737	0.00099778582588449	Apoptosis: DFFA
hsa04912__26	0.000564696642543045	DOWN	-3.44872755771793	0.00101246659478853	GnRH signaling pathway: PLD1
hsa04520__4	0.000570579956659872	DOWN	-3.44592712933164	0.00102203978890744	Adherens junction: CTNND1
hsa04919__91	0.000576520308320149	DOWN	-3.44312670094535	0.00103169681841291	Thyroid hormone signaling pathway: PFKP
hsa05205__158	0.000591624056720774	DOWN	-3.43612562997962	0.00105771798532667	Proteoglycans in cancer: PDCD4
hsa05164__53	0.000594688667852419	UP	3.43472541578647	0.00106218631834097	Influenza A: MAPK14
hsa04010__117	0.000597768050253284	DOWN	-3.43332520159333	0.00106667252272167	MAPK signaling pathway: JUND
hsa04520__44 52 45	0.000610234598990871	UP	3.42772434482074	0.00108788502040213	Adherens junction: ACTB ACTN4 CTNNA1
hsa04970__39	0.000619741706198455	UP	3.42352370224131	0.00110169987676673	Salivary secretion: KCNN4
hsa04917__46	0.000619742825834186	DOWN	-3.42352370224131	0.00110169987676673	Prolactin signaling pathway: GCK
hsa05162__101	0.000619742825834186	DOWN	-3.42352370224131	0.00110169987676673	Measles: CDKN1B
hsa05200__222	0.00062938874985403	UP	3.41932305966187	0.00111778966065758	Pathways in cancer: CASP9*
hsa04390__96	0.000649100996598398	DOWN	-3.41092177450299	0.00115170988914862	Hippo signaling pathway: FGF1
hsa04950__21	0.00065579831995295	UP	3.4081213461167	0.00116249532376565	Maturity onset diabetes of the young: PKLR
hsa04350__50	0.000662559856608828	DOWN	-3.40532091773041	0.00117337414756643	TGF-beta signaling pathway: AMHR2
hsa05200__212	0.000693796586167831	DOWN	-3.3927189899921	0.00122753652110109	Pathways in cancer: CCND1***
hsa04933__61	0.000704509342602151	DOWN	-3.38851834741266	0.0012453180195197	AGE-RAGE signaling pathway in diabetic complications: MMP2
hsa04010__119	0.000715375642138363	DOWN	-3.38431770483323	0.00126333724772367	MAPK signaling pathway: NFATC3
hsa05221__5	0.000726397490982757	UP	3.38011706225379	0.00128159707564	Acute myeloid leukemia: SPI1
hsa05152__126	0.000745118426717971	DOWN	-3.37311599128806	0.00131339354953383	Tuberculosis: NOS2
hsa04015__96	0.00076041674461816	DOWN	-3.36751513451548	0.00133910315195644	Rap1 signaling pathway: PLCE1
hsa04919__44	0.000768174796593495	UP	3.36471470612919	0.0013514985419468	Thyroid hormone signaling pathway: PFKFB2
hsa04064__135	0.000779949756138108	DOWN	-3.36051406354975	0.00137093133001263	NF-kappa B signaling pathway: CCL19
hsa04933__22	0.000871555115368898	DOWN	-3.32970935130054	0.00152908689241658	AGE-RAGE signaling pathway in diabetic complications: EDN1
hsa05152__81	0.000871555115368898	UP	3.32970935130054	0.00152908689241658	Tuberculosis: IFNA1
hsa04068__52	0.000875947046895234	DOWN	-3.3283091371074	0.00153535867641431	FoxO signaling pathway: CAT
hsa04622__6	0.00088035948977983	DOWN	-3.32690892291425	0.00154165468899935	RIG-I-like receptor signaling pathway: NFKB1
hsa04024__43	0.000930275256313053	DOWN	-3.31150656678965	0.00162452342621954	cAMP signaling pathway: MAPK8
hsa05100__33	0.000930275256313053	UP	3.31150656678965	0.00162452342621954	Bacterial invasion of epithelial cells: DNM1
hsa05169__118	0.000930275256313053	UP	3.31150656678965	0.00162452342621954	Epstein-Barr virus infection: MDM2
hsa04152__103	0.000944336756695643	DOWN	-3.30730592421021	0.00164754760058599	AMPK signaling pathway: ULK1
hsa04727__35	0.000953820200597526	DOWN	-3.30450549582392	0.00166254931068901	GABAergic synapse: PRKACA
hsa05200__183	0.000958594931921872	DOWN	-3.30310528163077	0.00166932333371751	Pathways in cancer: BMP2
hsa05164__78	0.00100757486473226	UP	3.28910313969932	0.00175299367669622	Influenza A: GSK3B
hsa04370__14	0.00101259820289057	DOWN	-3.28770292550617	0.00176010362926122	VEGF signaling pathway: PTGS2
hsa04012__40	0.00101764471428574	DOWN	-3.28630271131302	0.00176560888101838	ErbB signaling pathway: ELK1*
hsa04064__36	0.00101764471428574	UP	3.28630271131302	0.00176560888101838	NF-kappa B signaling pathway: PLCG1
hsa04668__111	0.00102780764498628	UP	3.28350228292673	0.00178159646211183	TNF signaling pathway: BAG4
hsa04390__18	0.0010380644367959	DOWN	-3.28070185454044	0.0017960617649535	Hippo signaling pathway: MOB1A
hsa05223__21	0.0010380644367959	DOWN	-3.28070185454044	0.0017960617649535	Non-small cell lung cancer: FOXO3*
hsa04068__13	0.00104322827591909	UP	3.2793016403473	0.00180167824490072	FoxO signaling pathway: PCK1
hsa05166__32	0.00104322827591909	DOWN	-3.2793016403473	0.00180167824490072	HTLV-I infection: STAT5A
hsa05221__27	0.00105886275224704	DOWN	-3.27510099776786	0.00182700010236197	Acute myeloid leukemia: PIM2
hsa05140__62	0.00106940586457214	DOWN	-3.27230056938157	0.00184349873351472	Leishmaniasis: C00584
hsa04024__91	0.00107471375976891	DOWN	-3.27090035518842	0.00185095064583481	cAMP signaling pathway: GRIA1
hsa04068__40	0.00109078401378632	DOWN	-3.26669971260898	0.0018769076574217	FoxO signaling pathway: CCND1
hsa04976__95 96	0.00109615578111693	UP	3.26529949841584	0.00188442517174631	Bile secretion: SLC51A SLC51B
hsa05166__5	0.00114033785591709	DOWN	-3.25409778487067	0.00195858759713731	HTLV-I infection: SLC2A1
hsa04210__59	0.00115162874025381	UP	3.25129735648438	0.00197257101452772	Apoptosis: PMAIP1
hsa04950__8	0.00115162874025381	UP	3.25129735648438	0.00197257101452772	Maturity onset diabetes of the young: NEUROD1
hsa05162__25 70	0.00115162874025381	DOWN	-3.25129735648438	0.00197257101452772	Measles: IFNAR1 GNB2L1
hsa04530__11 33	0.00115731284824805	UP	3.24989714229124	0.00198050167746639	Tight junction: TJP1 CGN
hsa04152__77	0.00117452111540502	UP	3.2456964997118	0.00200812117911377	AMPK signaling pathway: CCND1
hsa04918__14	0.00123966106140145	UP	3.2302941435872	0.00211756648579393	Thyroid hormone synthesis: DUOX2
hsa04151__32	0.00124574536280011	UP	3.22889392939405	0.00212602682715842	PI3K-Akt signaling pathway: BCL2L1
hsa04915__28	0.0012579967712742	DOWN	-3.22609350100776	0.00214498723523069	Estrogen signaling pathway: KCNJ3
hsa04919__87	0.00128283398454638	UP	3.22049264423518	0.00218535363278571	Thyroid hormone signaling pathway: BAD
hsa05161__207	0.00129542161740277	UP	3.21769221584888	0.00220280291321249	Hepatitis B: CDK2
hsa05161__219	0.00129542161740277	UP	3.21769221584888	0.00220280291321249	Hepatitis B: CDK2*
hsa05205__220	0.00130175809347767	DOWN	-3.21629200165574	0.00221157636315058	Proteoglycans in cancer: FAS
hsa05205__215 216	0.00132093955460657	DOWN	-3.2120913590763	0.00224213678690673	Proteoglycans in cancer: EIF4B RPS6
hsa04932__97	0.00133387172629255	UP	3.20929093069001	0.00226204420009359	Non-alcoholic fatty liver disease (NAFLD): TNF*
hsa04916__8	0.00135348913925698	DOWN	-3.20509028811057	0.00229324264442187	Melanogenesis: TYR*
hsa04022__59	0.00137337239716397	DOWN	-3.20088964553114	0.00232274233507749	cGMP-PKG signaling pathway: NPPB
hsa04915__30	0.00137337239716397	DOWN	-3.20088964553114	0.00232274233507749	Estrogen signaling pathway: CREB3*
hsa05221__29	0.00140030256131744	UP	3.19528878875855	0.00236615873445635	Acute myeloid leukemia: RPS6KB1
hsa03320__40	0.00141394947016079	DOWN	-3.19248836037226	0.0023870719267135	PPAR signaling pathway: FABP4
hsa05221__41	0.00142771890688937	DOWN	-3.18968793198597	0.00240815424241034	Acute myeloid leukemia: MAPK1
hsa04066__5	0.00144161186265738	DOWN	-3.18688750359968	0.00242940689680109	HIF-1 signaling pathway: VEGFA
hsa04151__102	0.00144860497181486	DOWN	-3.18548728940653	0.00243900424913989	PI3K-Akt signaling pathway: C8orf44-SGK3
hsa04310__13	0.00150568563756677	DOWN	-3.17428557586137	0.00253284092478779	Wnt signaling pathway: NFATC1
hsa05210__40	0.00151296460581434	UP	3.17288536166822	0.00254280902891337	Colorectal cancer: CASP9
hsa04010__131	0.00153499644948219	DOWN	-3.16868471908878	0.00257293338856114	MAPK signaling pathway: MYC
hsa04913__21	0.00153499644948219	DOWN	-3.16868471908878	0.00257293338856114	Ovarian steroidogenesis: CYP17A1
hsa04913__22	0.00153499644948219	DOWN	-3.16868471908878	0.00257293338856114	Ovarian steroidogenesis: CYP17A1*
hsa03320__37	0.00154240581134113	UP	3.16728450489564	0.00258304859136362	PPAR signaling pathway: HMGCS2
hsa04380__48	0.00154984809847739	UP	3.16588429070249	0.00259089375181407	Osteoclast differentiation: NFATC1
hsa04620__77	0.00154984809847739	UP	3.16588429070249	0.00259089375181407	Toll-like receptor signaling pathway: CXCL9
hsa04360__20	0.0016417720960533	DOWN	-3.14908172038474	0.00274212423865258	Axon guidance: ROCK1
hsa04151__109	0.00168959179945089	UP	3.14068043522587	0.00281948755876396	PI3K-Akt signaling pathway: RXRA
hsa04380__16	0.00177214696477088	UP	3.12667829329441	0.00295462657214241	Osteoclast differentiation: NFKB1
hsa05200__53	0.00179762715807383	UP	3.12247765071497	0.0029944516223588	Pathways in cancer: BCL2L1
hsa04530__11 62	0.00182344368510701	DOWN	-3.11827700813554	0.00303476588513381	Tight junction: TJP1 SHROOM1
hsa04064__133	0.00186722946112531	DOWN	-3.11127593716981	0.00310214337529129	NF-kappa B signaling pathway: CXCL2
hsa04360__40 139	0.00186722946112531	DOWN	-3.11127593716981	0.00310214337529129	Axon guidance: UNC5D DCC
hsa04012__43	0.00191197923042437	DOWN	-3.10427486620408	0.00317368283919382	ErbB signaling pathway: PTK2
hsa05160__77	0.00192104652827543	UP	3.10287465201093	0.00318591917619552	Hepatitis C: NFKB1*
hsa04261__15 16	0.00196697817348668	DOWN	-3.09587358104521	0.00325921692061858	Adrenergic signaling in cardiomyocytes: ACTC1 TPM1
hsa03320__63	0.00197628461817919	UP	3.09447336685206	0.0032717522445451	PPAR signaling pathway: DBI
hsa04670__86	0.00198563146532119	DOWN	-3.09307315265891	0.0032843323268825	Leukocyte transendothelial migration: ACTB
hsa05133__27	0.00199501887190855	DOWN	-3.09167293846577	0.00329695730898519	Pertussis: IRF3
hsa04350__11	0.00205220391747718	DOWN	-3.08327165330689	0.00338848080926153	TGF-beta signaling pathway: SMAD4*
hsa04012__35	0.0020813568699382	DOWN	-3.07907101072746	0.00343359926129401	ErbB signaling pathway: CBLC
hsa05200__173	0.00209115862122589	UP	3.07767079653431	0.00344372221672519	Pathways in cancer: CCNA1
hsa05221__16	0.00209115862122589	UP	3.07767079653431	0.00344372221672519	Acute myeloid leukemia: CCNA1
hsa04950__16	0.00218129854898427	UP	3.065068868796	0.00358274473211664	Maturity onset diabetes of the young: PAX4
hsa05200__5	0.00218129854898427	UP	3.065068868796	0.00358274473211664	Pathways in cancer: CASP3*
hsa05210__7	0.00218129854898427	UP	3.065068868796	0.00358274473211664	Colorectal cancer: CASP3*
hsa04210__52	0.00219153092711028	DOWN	-3.06366865460285	0.0035964075214325	Apoptosis: PARP2
hsa03320__60	0.00223290192006226	DOWN	-3.05806779783027	0.00366110183926439	PPAR signaling pathway: CYP27A1
hsa04390__78	0.00227498744330978	DOWN	-3.05246694105769	0.00372685388489894	Hippo signaling pathway: SOX2
hsa04062__42	0.00228562175514752	DOWN	-3.05106672686454	0.00374101330829459	Chemokine signaling pathway: PAK1
hsa05142__21	0.00233947956958693	DOWN	-3.04406565589881	0.00382583299499899	Chagas disease (American trypanosomiasis): TICAM1
hsa04976__34	0.00238339984897627	UP	3.03846479912623	0.00389426810106644	Bile secretion: SLCO1B1
hsa04670__39	0.00240564189342135	DOWN	-3.03566437073994	0.00392719471567222	Leukocyte transendothelial migration: MAPK14
hsa03320__41	0.00243936137019336	UP	3.0314637281605	0.00397533392419195	PPAR signaling pathway: ANGPTL4
hsa05120__19	0.00243936137019336	UP	3.0314637281605	0.00397533392419195	Epithelial cell signaling in Helicobacter pylori infection: CXCL1
hsa04024__59	0.00246208073585084	DOWN	-3.02866329977421	0.00400888189138972	cAMP signaling pathway: MLLT4
hsa04976__38	0.00256673332708018	DOWN	-3.0160613720359	0.00417566400137113	Bile secretion: ABCC2
hsa04115__50	0.00261453844320735	UP	3.01046051526332	0.00424975582593998	p53 signaling pathway: RCHY1
hsa04350__27	0.00265092494047195	UP	3.00625987268388	0.00430517542190734	TGF-beta signaling pathway: ACVR2A*
hsa04917__31	0.00268777373905917	DOWN	-3.00205923010444	0.00436124944360292	Prolactin signaling pathway: GALT
hsa04670__45	0.00270016030551877	DOWN	-3.0006590159113	0.00437756791550455	Leukocyte transendothelial migration: PXN
hsa05133__30	0.00280114634302882	DOWN	-2.98945730236613	0.00453737411944065	Pertussis: NOS2
hsa04662__24	0.00281400924321058	DOWN	-2.98805708817298	0.00455428369336148	B cell receptor signaling pathway: FOS
hsa05152__78	0.00286600202696869	UP	2.9824562314004	0.00463443873379877	Tuberculosis: IL1A
hsa05142__53	0.00287913652625412	UP	2.98105601720726	0.00465167457681125	Chagas disease (American trypanosomiasis): AKT3
hsa05010__51	0.0029591041328633	DOWN	-2.97265473204838	0.00477676689488843	Alzheimer's disease: ATF6
hsa04723__7	0.00298620707071886	DOWN	-2.96985430366209	0.0048163803312281	Retrograde endocannabinoid signaling: ITPR1
hsa04550__17	0.00301353630626259	DOWN	-2.9670538752758	0.00485629049697034	Signaling pathways regulating pluripotency of stem cells: AKT3
hsa05221__13	0.00302728630819166	DOWN	-2.96565366108265	0.00487426818602581	Acute myeloid leukemia: NFKB1
hsa04650__116	0.00306888037426867	UP	2.96145301850322	0.00493700875278324	Natural killer cell mediated cytotoxicity: FCGR3A
hsa05215__30	0.00325521080909145	UP	2.94325023399232	0.00523228495319318	Prostate cancer: TP53
hsa05014__51	0.00326996237148512	DOWN	-2.94185001979918	0.00525150367181243	Amyotrophic lateral sclerosis (ALS): DERL1
hsa05210__53	0.00328477480960536	DOWN	-2.94044980560603	0.00527078724786377	Colorectal cancer: CCND1*
hsa04621__44	0.00329964834550883	UP	2.93904959141288	0.00529013587134052	NOD-like receptor signaling pathway: MAPK14
hsa04662__36	0.00331458320192804	UP	2.93764937721974	0.00530954973267075	B cell receptor signaling pathway: CD79A
hsa04931__137	0.00345179342022495	DOWN	-2.92504744948143	0.00552463359165475	Insulin resistance: MLXIP*
hsa04728__61	0.00349866648281929	DOWN	-2.92084680690199	0.00559013122552505	Dopaminergic synapse: KCNJ3
hsa04961__17	0.00349866648281929	UP	2.92084680690199	0.00559013122552505	Endocrine and other factor-regulated calcium reabsorption: CALB1
hsa04062__43	0.00353023619735504	DOWN	-2.9180463785157	0.00563578064131701	Chemokine signaling pathway: STAT1
hsa05205__103	0.00361029759973863	DOWN	-2.91104530754997	0.00575870050077155	Proteoglycans in cancer: CCND1
hsa04520__17	0.00374183611781311	DOWN	-2.8998435940048	0.00596345213347823	Adherens junction: SNAI1
hsa04062__33	0.00375858116857942	DOWN	-2.89844337981166	0.00598506272522095	Chemokine signaling pathway: WAS
hsa04540__11	0.00377539429975276	DOWN	-2.89704316561851	0.00600674503745592	Gap junction: C00780
hsa04062__8 41	0.00380922577883014	DOWN	-2.89424273723222	0.006050325645327	Chemokine signaling pathway: PXN PTK2B
hsa04621__30 32	0.00380922577883014	DOWN	-2.89424273723222	0.006050325645327	NOD-like receptor signaling pathway: PYCARD CASP1
hsa04950__22	0.00382624461629511	UP	2.89284252303908	0.00607222435305618	Maturity onset diabetes of the young: NR5A2
hsa04621__6	0.00387771647298255	DOWN	-2.88864188045964	0.00614353225357016	NOD-like receptor signaling pathway: NFKB1
hsa05168__9	0.00387771647298255	DOWN	-2.88864188045964	0.00614353225357016	Herpes simplex infection: NFKB1
hsa04620__18	0.00392981654752694	UP	2.8844412378802	0.00622083006975831	Toll-like receptor signaling pathway: CXCL11
hsa05164__65 66	0.00394732400570165	DOWN	-2.88304102368705	0.00623803347915341	Influenza A: DNAJC3 HSPA1A
hsa05215__34	0.00394732400570165	UP	2.88304102368705	0.00623803347915341	Prostate cancer: BAD
hsa04630__1	0.00398255157683673	UP	2.88024059530076	0.00628841547300523	Jak-STAT signaling pathway: MYC
hsa05222__32	0.00408995374554862	DOWN	-2.87183931014189	0.00645258025851037	Small cell lung cancer: BIRC8
hsa04668__153	0.00412633442171528	UP	2.8690388817556	0.00650451541812333	TNF signaling pathway: MAPK14*
hsa04014__100	0.00431268061997189	DOWN	-2.85503673982414	0.00679256235115439	Ras signaling pathway: REL
hsa05150__40	0.00442811843455459	UP	2.84663545466527	0.00696853813947076	Staphylococcus aureus infection: FCGR1A
hsa04924__52	0.0044672155457441	UP	2.84383502627897	0.00702418243552566	Renin secretion: KCNJ2
hsa05145__13	0.00464705183127154	UP	2.83123309854066	0.00730084480849434	Toxoplasmosis: GNAI1
hsa04728__71 72	0.00487574096216437	DOWN	-2.81583074241606	0.00765373205338919	Dopaminergic synapse: CLOCK ARNTL
hsa05213__11	0.00491839829312939	DOWN	-2.81303031402977	0.00770781517330286	Endometrial cancer: FOXO3
hsa05321__138	0.00491839829312939	UP	2.81303031402977	0.00770781517330286	Inflammatory bowel disease (IBD): IFNG**
hsa05205__34	0.00504840330988842	DOWN	-2.80462902887089	0.00790495818273361	Proteoglycans in cancer: SLC9A1
hsa04740__13	0.00520399688176128	DOWN	-2.79482752951887	0.00814180694490379	Olfactory transduction: CNGA3
hsa05160__8	0.00524924114663174	DOWN	-2.79202710113258	0.00820440253117488	Hepatitis C: NFKB1
hsa05169__11	0.00525273882118328	DOWN	-2.5567911166841	0.00820440253117488	Epstein-Barr virus infection: HLA-A
hsa04510__20 4 5	0.00531777403167583	DOWN	-2.78782645855315	0.00829219701702813	Focal adhesion: VASP ITGB1 ITGA11
hsa05142__18	0.00531777403167583	DOWN	-2.78782645855315	0.00829219701702813	Chagas disease (American trypanosomiasis): FOS
hsa03320__56	0.00534079727054174	UP	2.78642624436	0.00831429831926092	PPAR signaling pathway: FADS2
hsa05218__9	0.00534079727054174	UP	2.78642624436	0.00831429831926092	Melanoma: CCND1
hsa04670__15	0.00536390577004754	DOWN	-2.78502603016685	0.00834336005125771	Leukocyte transendothelial migration: PECAM1
hsa04014__55	0.00548083703150204	DOWN	-2.77802495920113	0.0085181908868423	Ras signaling pathway: MLLT4
hsa05205__109	0.00557602936168611	DOWN	-2.77242410242854	0.00865897452116381	Proteoglycans in cancer: SMAD2
hsa04062__59	0.00567271098649925	DOWN	-2.76682324565596	0.00880183645221477	Chemokine signaling pathway: FOXO3
hsa04390__88	0.00569711645968259	DOWN	-2.76542303146281	0.00883241074896336	Hippo signaling pathway: ID1
hsa05205__183	0.00572161659453179	UP	2.76402281726967	0.0088630812705072	Proteoglycans in cancer: VEGFA*
hsa04210__70	0.00577090212586542	DOWN	-2.76122238888338	0.00892471201193509	Apoptosis: CFLAR*
hsa04976__36	0.00577090212586542	DOWN	-2.76122238888338	0.00892471201193509	Bile secretion: SLC10A1
hsa04710__11	0.00584554838703761	UP	2.75702174630394	0.00902529615385676	Circadian rhythm: CRY1
hsa05200__187	0.00584554838703761	DOWN	-2.75702174630394	0.00902529615385676	Pathways in cancer: WNT16*
hsa04742__31	0.00594643049439512	DOWN	-2.75142088953136	0.0091735163374125	Taste transduction: C00076*
hsa05142__67	0.00604887886128838	UP	2.74582003275877	0.00932390761309341	Chagas disease (American trypanosomiasis): IFNGR1*
hsa04810__26 80	0.00615291454130309	DOWN	-2.74021917598619	0.00947649706812172	Regulation of actin cytoskeleton: PFN3 ACTB
hsa04724__33 70 69	0.00625855881386829	UP	2.73461831921361	0.00963131204853277	Glutamatergic synapse: ITPR1 HOMER3 HOMER3
hsa04922__70	0.00628522373990197	DOWN	-2.73321810502046	0.00965652935999657	Glucagon signaling pathway: PFKFB1
hsa05205__145	0.00628522373990197	DOWN	-2.73321810502046	0.00965652935999657	Proteoglycans in cancer: PXN
hsa04310__16	0.00642008844228413	DOWN	-2.72621703405473	0.0098556749861535	Wnt signaling pathway: CAMK2A
hsa04115__1	0.00647475939244254	UP	2.72341660566844	0.00992338735595394	p53 signaling pathway: SIAH1
hsa04668__20	0.00647475939244254	UP	2.72341660566844	0.00992338735595394	TNF signaling pathway: IKBKG
hsa04621__23	0.00652984878914122	DOWN	-2.72061617728215	0.00999966248964658	NOD-like receptor signaling pathway: CASP1
hsa05132__55	0.00655755126919322	UP	2.719215963089	0.0100339078459398	Salmonella infection: IL18
hsa04370__25	0.00664129400634495	DOWN	-2.71501532050957	0.0101537765971702	VEGF signaling pathway: PXN
hsa05321__123	0.006669421181422	DOWN	-2.71361510631642	0.0101884897560097	Inflammatory bowel disease (IBD): IL5*
hsa04725__64	0.00678300389288761	DOWN	-2.70801424954384	0.0103535859583557	Cholinergic synapse: KCNJ3
hsa04012__37 7	0.00686932854136751	UP	2.7038136069644	0.0104683441437385	ErbB signaling pathway: ERBB3 ERBB3
hsa05200__96	0.00686932854136751	DOWN	-2.7038136069644	0.0104683441437385	Pathways in cancer: C00416
hsa05231__17	0.00716425155051291	DOWN	-2.68981146503294	0.0109089373285363	Choline metabolism in cancer: SLC44A3
hsa04660__56	0.0072549184053114	DOWN	-2.68561082245351	0.0110380499462187	T cell receptor signaling pathway: CD3E
hsa04666__29	0.00737740894589954	DOWN	-2.68000996568092	0.0112062662969646	Fc gamma R-mediated phagocytosis: WAS
hsa05014__49	0.00737740894589954	UP	2.68000996568092	0.0112062662969646	Amyotrophic lateral sclerosis (ALS): C00001
hsa04064__2	0.00750175148868005	DOWN	-2.67440910890834	0.011385937841058	NF-kappa B signaling pathway: BCL2L1
hsa04010__12	0.00759623822578341	UP	2.6702084663289	0.0115200416676731	MAPK signaling pathway: PLA2G4B
hsa05134__70	0.00775608899283699	DOWN	-2.66320739536318	0.0117529767883393	Legionellosis: IL6
hsa04750__40	0.00791894737472885	DOWN	-2.65620632439745	0.0119900903441704	Inflammatory mediator regulation of TRP channels: C00219
hsa05134__9	0.00808486182769631	UP	2.64920525343172	0.012231445550919	Legionellosis: CASP7
hsa04390__75	0.00818589779848922	DOWN	-2.64500461085228	0.0123743378627202	Hippo signaling pathway: NKD1
hsa05161__29	0.00821982671117801	DOWN	-2.64360439665914	0.0124156385774144	Hepatitis B: NFKB1
hsa05169__30	0.00863690028276544	DOWN	-2.62680182634139	0.0130351290211376	Epstein-Barr virus infection: FGR
hsa04520__34	0.0087082225980614	DOWN	-2.62400139795509	0.0131322233240428	Adherens junction: RHOA
hsa05212__10	0.0088524482053646	UP	2.61840054118251	0.0133390137753649	Pancreatic cancer: BCL2L1
hsa05160__12 13 14	0.00914731656884932	DOWN	-2.60719882763735	0.0137722819173621	Hepatitis C: IKBKG CHUK IKBKB
hsa05220__50	0.00926013279479278	DOWN	-2.60299818505791	0.0139309763982511	Chronic myeloid leukemia: MAPK1
hsa04670__55	0.00945092110238456	UP	2.59599711409218	0.0141952683863954	Leukocyte transendothelial migration: RAC2
hsa04917__34	0.00945092110238456	UP	2.59599711409218	0.0141952683863954	Prolactin signaling pathway: ELF5
hsa04115__25	0.00952821290571748	UP	2.59319668570589	0.0142999297522709	p53 signaling pathway: CD82
hsa04350__10	0.0100852213091787	DOWN	-2.57359368700185	0.0151238075338762	TGF-beta signaling pathway: SMAD4
hsa04620__76	0.0101260955466692	DOWN	-2.5721934728087	0.0151609032129015	Toll-like receptor signaling pathway: CCL3L3
hsa04925__5	0.0101260955466692	DOWN	-2.5721934728087	0.0151609032129015	Aldosterone synthesis and secretion: KCNK3
hsa04213__62	0.0101671172228894	UP	2.57079325861556	0.0152102016415678	Longevity regulating pathway - multiple species: CAT*
hsa04622__44	0.010208286788953	UP	2.56939304442241	0.0152596427020228	RIG-I-like receptor signaling pathway: MAPK8
hsa04310__34	0.0102496046970192	DOWN	-2.56799283022927	0.0153092267294905	Wnt signaling pathway: FOSL1
hsa04950__18	0.010374453010528	UP	2.56379218764983	0.015483397304831	Maturity onset diabetes of the young: SLC2A2
hsa04976__59	0.0105855428785803	DOWN	-2.5567911166841	0.0157859008482955	Bile secretion: ABCB4
hsa04064__53	0.010757156287664	DOWN	-2.55119025991152	0.0160291012406984	NF-kappa B signaling pathway: CXCL8
hsa05205__144	0.010887485038106	UP	2.54698961733208	0.0162104472160073	Proteoglycans in cancer: NUDT16L1
hsa05161__68	0.0111078203071205	DOWN	-2.53998854636635	0.016525411209089	Hepatitis B: JUN
hsa04917__40	0.0111970576668835	DOWN	-2.53718811798006	0.0166449931614511	Prolactin signaling pathway: TH
hsa04530__7 52	0.0112419146575234	DOWN	-2.53578790378691	0.0166984645387244	Tight junction: PARD6A MPP5
hsa04210__99	0.0112869311584043	DOWN	-2.53438768959377	0.0167520881885006	Apoptosis: BID**
hsa04727__17 37	0.0113321076481675	DOWN	-2.53298747540062	0.0168058644600684	GABAergic synapse: GABRA1 GPHN
hsa04062__53	0.0118868803505287	DOWN	-2.51618490508287	0.0176147067654917	Chemokine signaling pathway: NFKB1
hsa04340__33	0.0121250552882023	DOWN	-2.50918383411715	0.0179393534539623	Hedgehog signaling pathway: HHIP*
hsa04917__56	0.0121250552882023	DOWN	-2.50918383411715	0.0179393534539623	Prolactin signaling pathway: LHCGR
hsa04530__5 10	0.012367449999715	DOWN	-2.50218276315142	0.0182835865849445	Tight junction: IGSF5 MAGI1
hsa04933__65	0.0124656034363799	DOWN	-2.49938233476513	0.018399739871923	AGE-RAGE signaling pathway in diabetic complications: COL1A1
hsa05162__20	0.0124656034363799	DOWN	-2.49938233476513	0.018399739871923	Measles: NFKB1
hsa04062__22 41	0.0125644460981247	DOWN	-2.49658190637883	0.0185310786643456	Chemokine signaling pathway: CRK PTK2B
hsa04915__40	0.0131205829096684	DOWN	-2.48117955025423	0.0193361374802094	Estrogen signaling pathway: CREB3**
hsa04066__37	0.0132240052604003	DOWN	-2.47837912186794	0.0194732804735832	HIF-1 signaling pathway: PDHA1
hsa04919__25	0.0133281477084522	UP	2.47557869348165	0.0196112682413326	Thyroid hormone signaling pathway: MTOR
hsa04670__2	0.0133804902780931	DOWN	-2.4741784792885	0.0196728804636439	Leukocyte transendothelial migration: MMP2
hsa05145__8	0.0134857207365495	DOWN	-2.47137805090221	0.0198120948115532	Toxoplasmosis: NFKB1
hsa05160__56	0.0135386096798738	DOWN	-2.46997783670906	0.0198742559285022	Hepatitis C: MAPK1
hsa04973__5	0.0136983777166283	UP	2.46577719412963	0.0200930926850465	Carbohydrate digestion and absorption: SLC2A5
hsa04931__77	0.0137517817176611	UP	2.46437697993648	0.0201403061775772	Insulin resistance: PPP2R4**
hsa04520__73	0.0137520025682978	UP	2.46437697993648	0.0201403061775772	Adherens junction: PARD3
hsa05200__196	0.0139139911088208	UP	2.46017633735704	0.0203616739045749	Pathways in cancer: TRAF1
hsa05032__31	0.0141325951563192	DOWN	-2.45457548058446	0.0206333693074777	Morphine addiction: GABRR3
hsa05032__33	0.0141325951563192	DOWN	-2.45457548058446	0.0206333693074777	Morphine addiction: GABRR3*
hsa05032__55	0.0141325951563192	DOWN	-2.45457548058446	0.0206333693074777	Morphine addiction: GABRR3**
hsa04670__18	0.014187689745677	DOWN	-2.45317526639132	0.0206817076641498	Leukocyte transendothelial migration: CDH5
hsa05217__22	0.0141877174981847	DOWN	-2.45317526639132	0.0206817076641498	Basal cell carcinoma: LEF1
hsa04810__8 79	0.0142985315702046	DOWN	-2.45037483800502	0.0208109533852939	Regulation of actin cytoskeleton: ARPC5 ACTB
hsa04810__8 82	0.0142985315702046	DOWN	-2.45037483800502	0.0208109533852939	Regulation of actin cytoskeleton: ARPC5 ACTB*
hsa03320__30	0.0148066979572851	DOWN	-2.43777291026671	0.0215338896762683	PPAR signaling pathway: LPL
hsa04668__128	0.0148641317924519	UP	2.43637269607357	0.0215840059026407	TNF signaling pathway: CHUK*
hsa05164__19	0.0148641317924519	DOWN	-2.43637269607357	0.0215840059026407	Influenza A: NFKB1
hsa04213__13	0.0151542552791804	DOWN	-2.42937162510784	0.0219713315351698	Longevity regulating pathway - multiple species: RPS6KB1*
hsa04662__6	0.0151542552791804	UP	2.42937162510784	0.0219713315351698	B cell receptor signaling pathway: NFKB1
hsa05152__88 89	0.0152128684939018	UP	2.42797141091469	0.0220053823410308	Tuberculosis: ITGAX ITGB2
hsa04621__34 35	0.0152128747530596	DOWN	-2.42797141091469	0.0220053823410308	NOD-like receptor signaling pathway: CASP1 PYCARD
hsa05212__8	0.0152128747530596	DOWN	-2.42797141091469	0.0220053823410308	Pancreatic cancer: NFKB1
hsa04912__19	0.0156890625193871	DOWN	-2.41676969736953	0.0226767295953294	GnRH signaling pathway: MAPK7
hsa05161__26	0.0160547601593702	UP	2.40836841221065	0.0231874668251012	Hepatitis B: MMP9
hsa04670__54	0.0161783137296518	UP	2.40556798382436	0.0233479658202886	Leukocyte transendothelial migration: RAC1*
hsa05205__400	0.016365210976125	DOWN	-2.40136734124492	0.0235995636409355	Proteoglycans in cancer: ITGA2*
hsa04912__20	0.0168086985325431	DOWN	-2.3915658418929	0.0242205096185954	GnRH signaling pathway: PLA2G4B
hsa05134__7	0.0168729075504997	UP	2.39016562769976	0.0242944009865049	Legionellosis: IL18
hsa05200__204	0.0169373317563953	DOWN	-2.38876541350661	0.0243684887980604	Pathways in cancer: TGFB1*
hsa03320__53	0.0175269315268634	DOWN	-2.3761634857683	0.0251974784536927	PPAR signaling pathway: ADIPOQ
hsa05161__69	0.0176603712531501	DOWN	-2.37336305738201	0.0253699064102975	Hepatitis B: SMAD4
hsa04724__3	0.0177274244079148	DOWN	-2.37196284318886	0.0254467765183132	Glutamatergic synapse: GRIK1
hsa04950__30	0.0178622003415943	UP	2.36916241480257	0.0256206675128669	Maturity onset diabetes of the young: PAX6*
hsa04071__89	0.0180660474596181	DOWN	-2.36496177222314	0.0258932899897959	Sphingolipid signaling pathway: C00533
hsa05160__71	0.0185496317387009	DOWN	-2.35516027287112	0.026566126552606	Hepatitis C: MAPK8
hsa05205__146	0.0186196318134814	DOWN	-2.35376005867797	0.0266460686805267	Proteoglycans in cancer: PTK2
hsa04064__137	0.0189019485181808	UP	2.34815920190539	0.0270294986801079	NF-kappa B signaling pathway: ICAM1
hsa04620__46	0.0189731099256375	UP	2.34675898771224	0.0271106262739717	Toll-like receptor signaling pathway: TNF
hsa04670__35	0.0194050175789225	DOWN	-2.33835770255337	0.0277067082300876	Leukocyte transendothelial migration: PTK2
hsa04014__64	0.0200689837489496	DOWN	-2.32575577481505	0.0286112446618182	Ras signaling pathway: PIK3R5*
hsa04933__30	0.0200689837489496	UP	2.32575577481505	0.0286112446618182	AGE-RAGE signaling pathway in diabetic complications: CXCL8
hsa04024__21	0.0203703886511823	DOWN	-2.32015491804247	0.0290189236357631	cAMP signaling pathway: AKT3
hsa04912__14	0.020599026369025	DOWN	-2.31595427546303	0.0293002048049947	GnRH signaling pathway: ATF4
hsa05169__103	0.020599026369025	DOWN	-2.31595427546303	0.0293002048049947	Epstein-Barr virus infection: NFKB1*
hsa04668__141	0.020829898560473	DOWN	-2.3117536328836	0.0296061871370112	TNF signaling pathway: JUN*
hsa04622__5 33	0.0214566169146356	UP	2.30055191933843	0.0304739101909299	RIG-I-like receptor signaling pathway: MAVS TMEM173
hsa05160__37	0.021775804478444	DOWN	-2.29495106256585	0.0308576691026464	Hepatitis C: STAT3
hsa04115__21	0.0217760879351299	UP	2.29495106256585	0.0308576691026464	p53 signaling pathway: DDB2
hsa05205__113	0.0217760879351299	UP	2.29495106256585	0.0308576691026464	Proteoglycans in cancer: TP53
hsa04621__43	0.0221812418331877	UP	2.28794999160012	0.0314081035452597	NOD-like receptor signaling pathway: MAPK1
hsa04621__42	0.0228431266410838	UP	2.27674827805495	0.0322966402999221	NOD-like receptor signaling pathway: MAPK8
hsa04931__35	0.0228431266410838	UP	2.27674827805495	0.0322966402999221	Insulin resistance: C00369
hsa05120__18	0.022927056805893	DOWN	-2.27534806386181	0.0323909321340398	Epithelial cell signaling in Helicobacter pylori infection: CCL5
hsa05130__9	0.0230112547139134	DOWN	-2.27394784966866	0.0324854602610393	Pathogenic Escherichia coli infection: TLR4
hsa05133__94	0.0230957210536602	DOWN	-2.27254763547552	0.0325802251199906	Pertussis: IL12A
hsa05205__319	0.0231804565147892	DOWN	-2.27114742128237	0.0326752271502543	Proteoglycans in cancer: KDR
hsa04210__62	0.0233507375655193	UP	2.26834699289608	0.0328659444836035	Apoptosis: TP53AIP1
hsa04666__27	0.0233507375655193	UP	2.26834699289608	0.0328659444836035	Fc gamma R-mediated phagocytosis: ARPC5
hsa04064__142	0.0234362845401322	DOWN	-2.26694677870293	0.0329616606668476	NF-kappa B signaling pathway: NFKB2*
hsa05200__225	0.0236081948589275	UP	2.26414635031664	0.0331538102690021	Pathways in cancer: PPARD
hsa05221__11	0.0236081948589275	UP	2.26414635031664	0.0331538102690021	Acute myeloid leukemia: PPARD
hsa05219__10	0.0242185261061638	DOWN	-2.25434485096462	0.0339855194574173	Bladder cancer: EGFR
hsa04115__27	0.0245733915748207	DOWN	-2.24874399419204	0.0344577632605135	p53 signaling pathway: THBS1
hsa04071__1	0.0249327533800656	UP	2.24314313741946	0.0349356029837011	Sphingolipid signaling pathway: MAPK1
hsa04916__7	0.025296657077243	DOWN	-2.23754228064687	0.0354190899017434	Melanogenesis: TYRP1
hsa04152__81	0.0254803264503973	DOWN	-2.23474185226058	0.0356231647323635	AMPK signaling pathway: LIPE
hsa05211__23	0.0254803264503973	DOWN	-2.23474185226058	0.0356231647323635	Renal cell carcinoma: PDGFB
hsa05032__30	0.025665118232971	UP	2.23194142387429	0.0358548380369907	Morphine addiction: ADORA1
hsa04068__47	0.0257579936027217	DOWN	-2.23054120968115	0.0359311581139674	FoxO signaling pathway: GADD45G
hsa04068__54	0.0257579936027217	DOWN	-2.23054120968115	0.0359311581139674	FoxO signaling pathway: GADD45G*
hsa04650__40	0.0258511290337731	UP	2.229140995488	0.0360343260047921	Natural killer cell mediated cytotoxicity: TNFRSF10D
hsa04660__44	0.0261322846143494	DOWN	-2.22494035290856	0.0363992311270293	T cell receptor signaling pathway: PAK4
hsa04110__46	0.0266067518938813	UP	2.21793928194283	0.0370326568952615	Cell cycle: RB1
hsa04750__44	0.026702449110692	DOWN	-2.21653906774969	0.0371108741708508	Inflammatory mediator regulation of TRP channels: TRPA1
hsa04750__63	0.026702449110692	DOWN	-2.21653906774969	0.0371108741708508	Inflammatory mediator regulation of TRP channels: TRPA1*
hsa04912__17	0.0267986119927648	DOWN	-2.21513885355654	0.0372169932996342	GnRH signaling pathway: MAPK14
hsa04621__29	0.0269916655845217	UP	2.21233842517025	0.0374574147956545	NOD-like receptor signaling pathway: CASP5
hsa05161__10	0.0271859185700286	UP	2.20953799678396	0.0376991446443422	Hepatitis B: CASP3
hsa05321__46	0.0278753348560196	UP	2.19973649743194	0.0386266623852956	Inflammatory bowel disease (IBD): IFNG*
hsa04520__9 57	0.0282760145358564	UP	2.19413564065936	0.0391241762245023	Adherens junction: LEF1 CTNNB1
hsa05162__62	0.0282760145358564	DOWN	-2.19413564065936	0.0391241762245023	Measles: IL12A
hsa04350__12	0.0295079636772735	DOWN	-2.17733307034161	0.0407987224058844	TGF-beta signaling pathway: ACVR2A
hsa04621__4 7 8	0.0296126792197121	UP	2.17593285614846	0.0409134001866464	NOD-like receptor signaling pathway: IKBKG CHUK IKBKB
hsa03320__46	0.0298230693561042	DOWN	-2.17313242776217	0.0411738040559293	PPAR signaling pathway: APOA2
hsa04213__2	0.0305695857241607	DOWN	-2.16333092841015	0.0421734593066799	Longevity regulating pathway - multiple species: RPS6KB1
hsa04210__60	0.0318866838099674	UP	2.1465283580924	0.0439582383557804	Apoptosis: BBC3
hsa04360__111	0.0321108643479343	DOWN	-2.14372792970611	0.0442348343913259	Axon guidance: RHOA***
hsa04350__21	0.0322234602610298	DOWN	-2.14232771551296	0.0443574225864286	TGF-beta signaling pathway: CDKN2B
hsa05142__29	0.0323363943264044	DOWN	-2.14092750131982	0.0444802964416646	Chagas disease (American trypanosomiasis): NOS2
hsa04024__93	0.0325632800889146	UP	2.13812707293353	0.0447596220095615	cAMP signaling pathway: ORAI1
hsa04912__33	0.0327915279958072	DOWN	-2.13532664454724	0.0450404101638317	GnRH signaling pathway: ELK1
hsa04670__73	0.0332521357678403	DOWN	-2.12972578777465	0.0456397100860277	Leukocyte transendothelial migration: MYL12B*
hsa04014__66	0.033368149035522	DOWN	-2.12832557358151	0.0457655124363109	Ras signaling pathway: RAF1*
hsa05162__28 34	0.0336012147769148	UP	2.12552514519522	0.0460515554820007	Measles: IRF9 STAT1
hsa04910__57	0.0347875373563624	DOWN	-2.11152300326376	0.0476426987555429	Insulin signaling pathway: GCK
hsa04024__115	0.03563908802316	DOWN	-2.10172150391174	0.048773376835774	cAMP signaling pathway: F2R
hsa04151__98	0.0370131451916775	UP	2.08631914778714	0.0506169576529564	PI3K-Akt signaling pathway: BCL2L1*
hsa05169__29	0.0373956261096625	DOWN	-2.0821185052077	0.0511028228800406	Epstein-Barr virus infection: FCER2
hsa04072__36	0.037523865033318	DOWN	-2.08071829101455	0.0512408011610498	Phospholipase D signaling pathway: MTOR
hsa04012__24	0.0376524779934773	DOWN	-2.07931807682141	0.0513790894333652	ErbB signaling pathway: CDKN1A
hsa04620__40	0.0379108293765358	DOWN	-2.07651764843512	0.051694084469166	Toll-like receptor signaling pathway: CCL5
hsa04921__80	0.0380405694784738	DOWN	-2.07511743424197	0.0518333792966296	Oxytocin signaling pathway: KCNJ2
hsa03320__64	0.0385633122561487	DOWN	-2.06951657746939	0.0524695609915304	PPAR signaling pathway: APOA5
hsa04931__40	0.0385633122561487	DOWN	-2.06951657746939	0.0524695609915304	Insulin resistance: PRKCZ
hsa05221__26	0.0393588664352491	UP	2.06111529231051	0.0535132489376505	Acute myeloid leukemia: BAD
hsa03320__9	0.0397618411329733	UP	2.05691464973108	0.054022053137279	PPAR signaling pathway: PCK1
hsa04380__51	0.0405783008173524	UP	2.0485133645722	0.0550914936674893	Osteoclast differentiation: FOS*
hsa04022__58	0.0409918320599339	DOWN	-2.04431272199276	0.055612745444488	cGMP-PKG signaling pathway: MYH7
hsa04024__109	0.0411304669307562	UP	2.04291250779962	0.0557605680828939	cAMP signaling pathway: BDNF
hsa05162__81	0.0412694988000947	UP	2.04151229360647	0.0559087153896019	Measles: TNFRSF10D
hsa04920__28	0.0414089285314388	DOWN	-2.04011207941333	0.0560571878318253	Adipocytokine signaling pathway: SLC2A1
hsa04710__23	0.042969162331135	UP	2.02470972328872	0.058127470136935	Circadian rhythm: BHLHE41
hsa04920__31	0.0432581150119236	UP	2.02190929490243	0.0584762576312262	Adipocytokine signaling pathway: AGRP
hsa04151__28	0.0441348422293342	UP	2.01350800974356	0.0595756957966372	PI3K-Akt signaling pathway: BCL2L11
hsa05014__33 34	0.0441348422293342	UP	2.01350800974356	0.0595756957966372	Amyotrophic lateral sclerosis (ALS): NEFH PRPH
hsa04370__23	0.0445788007709841	DOWN	-2.00930736716412	0.0601317779243928	VEGF signaling pathway: PTK2
hsa05132__20	0.0448768614999301	DOWN	-2.00650693877783	0.0604904037004079	Salmonella infection: ACTB
hsa04922__50	0.0450265210284968	DOWN	-2.00510672458468	0.0606486258154448	Glucagon signaling pathway: PCK1
hsa04650__14	0.0451766011812028	UP	2.00370651039154	0.0608071874065043	Natural killer cell mediated cytotoxicity: CSF2
hsa04933__58	0.0463924914996505	DOWN	-1.99250479684637	0.0623990633699665	AGE-RAGE signaling pathway in diabetic complications: CCL2
hsa04022__19	0.0467007326112373	DOWN	-1.98970436846008	0.0627687243036587	cGMP-PKG signaling pathway: CNGB1
hsa04024__34	0.0471663247297921	DOWN	-1.98550372588064	0.0633491952589559	cAMP signaling pathway: ATP2B1
hsa04961__20	0.0474788471994389	UP	1.98270329749435	0.0637233956341041	Endocrine and other factor-regulated calcium reabsorption: CALB1*
hsa04014__33	0.0481092274679944	UP	1.97710244072177	0.0645233678889089	Ras signaling pathway: BCL2L1
hsa05169__79	0.0490679170741486	DOWN	-1.96870115556289	0.0657622084039409	Epstein-Barr virus infection: ATF2
hsa03320__10	0.0497159104732516	DOWN	-1.96310029879031	0.0664883955724126	PPAR signaling pathway: PLIN1
hsa04920__5	0.0497159104732516	DOWN	-1.96310029879031	0.0664883955724126	Adipocytokine signaling pathway: NFKBIA
hsa05231__21	0.0497159104732516	DOWN	-1.96310029879031	0.0664883955724126	Choline metabolism in cancer: PCYT1A
hsa04062__35 36 37	0.0498790255213003	DOWN	-1.96170008459717	0.0666117192285169	Chemokine signaling pathway: PARD3 PRKCZ TIAM1
hsa05223__8	0.0498790255213003	DOWN	-1.96170008459717	0.0666117192285169	Non-small cell lung cancer: CASP9
hsa04068__49	0.0502066020288953	UP	1.95889965621087	0.0669540136354111	FoxO signaling pathway: BCL2L11
hsa05032__38	0.0502066020288953	DOWN	-1.95889965621087	0.0669540136354111	Morphine addiction: CACNA1A
hsa04062__44	0.0510334399592251	UP	1.95189858524515	0.068008392683251	Chemokine signaling pathway: MAPK1
hsa05160__66	0.0512001685737294	UP	1.950498371052	0.0681339353753807	Hepatitis C: GSK3B
hsa05160__85	0.0512001685737294	UP	1.950498371052	0.0681339353753807	Hepatitis C: BAD
hsa04612__18	0.052550483932062	UP	1.93929665750683	0.069881358321546	Antigen processing and presentation: KIR2DS2
hsa05212__12	0.0527213479560725	DOWN	-1.93789644331369	0.0700589906714711	Pancreatic cancer: CASP9
hsa05145__67	0.0539304425891735	UP	1.92809494396167	0.0716150541519837	Toxoplasmosis: BAD
hsa04152__53	0.0548081804054398	UP	1.92109387299594	0.0727292167950716	AMPK signaling pathway: G6PC
hsa04370__16	0.0551625955949973	DOWN	-1.91829344460965	0.073147859649259	VEGF signaling pathway: HSPB1
hsa04930__26	0.055697798881676	UP	1.91409280203021	0.0738054753869317	Type II diabetes mellitus: INS*
hsa04062__38	0.0560569989661191	UP	1.91129237364392	0.0742291057486524	Chemokine signaling pathway: NCF1
hsa04064__95	0.0578820549692141	DOWN	-1.89729023171246	0.0765918178078544	NF-kappa B signaling pathway: BCL2L1**
hsa04020__18	0.0590005152729622	UP	1.88888894655359	0.0778526222651216	Calcium signaling pathway: C00002
hsa04020__17	0.0590005152729622	UP	1.88888894655359	0.0778526222651216	Calcium signaling pathway: C00004
hsa04020__15	0.0590005152729622	UP	1.88888894655359	0.0778526222651216	Calcium signaling pathway: C13051
hsa05161__227	0.0590006035686712	UP	1.88888894655359	0.0778526222651216	Hepatitis B: MYD88*
hsa04151__101	0.0591887616557711	DOWN	-1.88748873236044	0.0780460934394343	PI3K-Akt signaling pathway: PKN3
hsa05211__41	0.0597562262224227	DOWN	-1.883288089781	0.0787390947208501	Renal cell carcinoma: PDGFB*
hsa04920__26	0.060519858372613	DOWN	-1.87768723300842	0.0796894280883952	Adipocytokine signaling pathway: NPY
hsa04610__7	0.0620713940597448	DOWN	-1.86648551946326	0.081675174676653	Complement and coagulation cascades: C00290
hsa05220__25	0.062267630007611	UP	1.86508530527011	0.0818760509337306	Chronic myeloid leukemia: BCL2L1*
hsa04910__42	0.0636556977228508	DOWN	-1.85528380591809	0.0835842459966713	Insulin signaling pathway: PCK1
hsa04972__42	0.0636556977228508	UP	1.85528380591809	0.0835842459966713	Pancreatic secretion: CFTR
hsa05161__44	0.0650692278368501	DOWN	-1.84548230656607	0.0853806418334087	Hepatitis B: CXCL8
hsa04666__30 44	0.0652732584323964	DOWN	-1.84408209237292	0.0855885921803719	Fc gamma R-mediated phagocytosis: C04637 GSN
hsa04917__44	0.0663013402740272	DOWN	-1.8370810214072	0.0868760239713369	Prolactin signaling pathway: PRLR**
hsa04750__7	0.0677629406390539	UP	1.82727952205518	0.088667524694138	Inflammatory mediator regulation of TRP channels: TRPV1
hsa04750__58	0.0677629406390539	UP	1.82727952205518	0.088667524694138	Inflammatory mediator regulation of TRP channels: TRPV1**
hsa05218__14	0.0690369115481125	UP	1.8188782368963	0.0902716470416865	Melanoma: BAD
hsa04662__35	0.0696811918104446	DOWN	-1.81467759431686	0.091050736725887	B cell receptor signaling pathway: CD79B
hsa04670__76	0.0703304001498743	UP	1.81047695173743	0.0918351785139776	Leukocyte transendothelial migration: CDC42
hsa04620__66	0.0705479025772607	UP	1.80907673754428	0.0920552145435228	Toll-like receptor signaling pathway: CASP8
hsa04340__17	0.0709845627180462	UP	1.80627630915799	0.0925607171042393	Hedgehog signaling pathway: SMO
hsa03320__27	0.0714234363714508	DOWN	-1.8034758807717	0.093068402872369	PPAR signaling pathway: CPT1C
hsa04068__43	0.0716437056906693	DOWN	-1.80207566657855	0.0932907297247177	FoxO signaling pathway: CDKN1A
hsa04066__11	0.0718645312989338	DOWN	-1.80067545238541	0.0935134725143328	HIF-1 signaling pathway: SLC2A1
hsa05161__195	0.0750150443017979	DOWN	-1.78107245368137	0.0975455143550714	Hepatitis B: IL6
hsa05213__12	0.0754741893229458	UP	1.77827202529507	0.098074689998489	Endometrial cancer: BAD
hsa05205__81	0.0757046205850993	UP	1.77687181110193	0.0983061382718739	Proteoglycans in cancer: CTTN
hsa04610__46	0.0778044399757197	UP	1.76426988336362	0.100893404219722	Complement and coagulation cascades: C2
hsa05321__94	0.0778044399757197	UP	1.76426988336362	0.100893404219722	Inflammatory bowel disease (IBD): IL22
hsa04064__52	0.0780406531275928	DOWN	-1.76286966917047	0.101129922225343	NF-kappa B signaling pathway: TRAF1
hsa05014__53	0.0787527978205677	UP	1.75866902659103	0.101982430809681	Amyotrophic lateral sclerosis (ALS): RAB5A
hsa04064__96	0.0811648830972229	UP	1.74466688465958	0.105033619379946	NF-kappa B signaling pathway: BCL2A1
hsa05212__27	0.0819000911725275	UP	1.74046624208014	0.105912093126758	Pancreatic cancer: BCL2L1*
hsa04370__38	0.0826406919214821	UP	1.7362655995007	0.106722927917845	VEGF signaling pathway: BAD
hsa05161__45	0.0826406919214821	UP	1.7362655995007	0.106722927917845	Hepatitis B: PCNA
hsa05132__68	0.0836365938040967	DOWN	-1.73066474272812	0.107934862471084	Salmonella infection: NOS2
hsa04360__31	0.0846421921376597	UP	1.72506388595554	0.109082770251483	Axon guidance: CDC42*
hsa05134__73	0.0846421921376597	UP	1.72506388595554	0.109082770251483	Legionellosis: CXCL1
hsa05162__78	0.0854027918155349	DOWN	-1.7208632433761	0.109987557108561	Measles: FAS
hsa04068__67	0.0856575494784608	DOWN	-1.71946302918295	0.11024009278769	FoxO signaling pathway: GABARAP
hsa04650__25	0.0859129209886672	DOWN	-1.71806281498981	0.110417495579826	Natural killer cell mediated cytotoxicity: SH2D1B
hsa05150__66	0.0859129209886672	UP	1.71806281498981	0.110417495579826	Staphylococcus aureus infection: IL10
hsa04723__46	0.086168907323353	UP	1.71666260079666	0.110670797580711	Retrograde endocannabinoid signaling: ADCY1
hsa04014__69	0.0877177913602264	DOWN	-1.70826131563779	0.112583148883788	Ras signaling pathway: PLCE1*
hsa03320__59	0.0887628009490234	DOWN	-1.70266045886521	0.113846623196734	PPAR signaling pathway: NR1H3
hsa04510__42	0.0906156896760573	DOWN	-1.69285895951319	0.116064676824343	Focal adhesion: BIRC2
hsa04910__39	0.0906156896760573	UP	1.69285895951319	0.116064676824343	Insulin signaling pathway: BAD
hsa04068__96	0.0908829098539378	DOWN	-1.69145874532004	0.116248459915282	FoxO signaling pathway: CCNG2
hsa05132__48	0.0908829098539378	DOWN	-1.69145874532004	0.116248459915282	Salmonella infection: KLC3
hsa04151__110	0.0911507634046773	DOWN	-1.69005853112689	0.116511758120673	PI3K-Akt signaling pathway: BCL2**
hsa04064__128	0.0919581340415414	DOWN	-1.68585788854746	0.117463857147557	NF-kappa B signaling pathway: IL1B*
hsa05223__23	0.093043554562848	DOWN	-1.68025703177487	0.118769591727983	Non-small cell lung cancer: CASP9*
hsa04650__39	0.0933165101746822	DOWN	-1.67885681758173	0.119037150453651	Natural killer cell mediated cytotoxicity: FAS
hsa04630__7	0.0963616170364069	UP	1.66345446145713	0.12283818074044	Jak-STAT signaling pathway: BCL2
hsa04020__22	0.0969236395827523	DOWN	-1.66065403307083	0.123470860187113	Calcium signaling pathway: C00575
hsa05133__96	0.0980557960709116	DOWN	-1.65505317629825	0.124828482938511	Pertussis: IL1B
hsa04024__25	0.0989117641934555	UP	1.65085253371881	0.125832907866962	cAMP signaling pathway: CFTR
hsa05166__99	0.0991984087042689	UP	1.64945231952567	0.126112185355427	HTLV-I infection: JUN
hsa04152__89	0.100641588290518	UP	1.64245124855994	0.127515539041054	AMPK signaling pathway: CFTR
hsa04727__26	0.100641588290518	DOWN	-1.64245124855994	0.127515539041054	GABAergic synapse: KCNJ6
hsa05032__81	0.100641588290518	DOWN	-1.64245124855994	0.127515539041054	Morphine addiction: KCNJ6
hsa05032__91	0.100641588290518	DOWN	-1.64245124855994	0.127515539041054	Morphine addiction: KCNJ6**
hsa05032__85	0.100641588290518	DOWN	-1.64245124855994	0.127515539041054	Morphine addiction: KCNJ6*
hsa05169__60	0.101223524768319	DOWN	-1.63965082017365	0.128166444096813	Epstein-Barr virus infection: NFKB1
hsa04910__20	0.104472234901128	DOWN	-1.62424846404904	0.13219079419476	Insulin signaling pathway: PKLR
hsa04064__136	0.104771632082829	UP	1.6228482498559	0.132391322584825	NF-kappa B signaling pathway: TNFSF13B*
hsa04064__97	0.104771632082829	UP	1.6228482498559	0.132391322584825	NF-kappa B signaling pathway: PLCG2
hsa05145__4 5	0.105673912321335	UP	1.61864760727646	0.133441721271364	Toxoplasmosis: MAP3K7 TAB1
hsa05150__48	0.106886528673058	UP	1.61304675050388	0.1348823286613	Staphylococcus aureus infection: C3AR1
hsa04068__42	0.107496958076302	UP	1.61024632211759	0.135561600151256	FoxO signaling pathway: CDKN2D
hsa04115__3	0.108726097518899	UP	1.604645465345	0.137019676215969	p53 signaling pathway: GADD45G
hsa04310__57	0.109344822804097	UP	1.60184503695871	0.137707052311594	Wnt signaling pathway: SIAH1
hsa05321__92	0.10965522766818	UP	1.60044482276557	0.13800547407134	Inflammatory bowel disease (IBD): IL17F
hsa05205__91	0.110278126590556	UP	1.59764439437928	0.138696519319715	Proteoglycans in cancer: RAC1*
hsa05150__1 2 3	0.112163605208471	UP	1.5892431092204	0.140973521195129	Staphylococcus aureus infection: CFD C3 CFB
hsa05200__214	0.113434651551069	UP	1.58364225244782	0.142475742155387	Pathways in cancer: CSF3R
hsa05145__23	0.115362462930903	UP	1.57524096728894	0.144800312523157	Toxoplasmosis: CIITA
hsa04550__62 63	0.115686255116965	DOWN	-1.5738407530958	0.145109795303589	Signaling pathways regulating pluripotency of stem cells: SMAD2 SMAD4
hsa05152__68	0.11633598246797	UP	1.57104032470951	0.145827425655314	Tuberculosis: CD74
hsa04024__114	0.117315944983807	DOWN	-1.56683968213007	0.146957773749715	cAMP signaling pathway: HHIP
hsa04727__49	0.117972807559468	UP	1.56403925374378	0.147682148836936	GABAergic synapse: GABRR3
hsa04151__63	0.118963602085531	DOWN	-1.55983861116434	0.148823307802073	PI3K-Akt signaling pathway: CASP9
hsa04024__123	0.119627721851202	DOWN	-1.55703818277805	0.149455112605324	cAMP signaling pathway: PAK1
hsa05200__49	0.119627721851202	DOWN	-1.55703818277805	0.149455112605324	Pathways in cancer: CASP9
hsa05200__226	0.119960869078973	DOWN	-1.5556379685849	0.149771742856738	Pathways in cancer: CDKN1A*
hsa04370__39	0.120964671269575	DOWN	-1.55143732600547	0.150924712692916	VEGF signaling pathway: RAC1
hsa04917__57	0.121975033654806	DOWN	-1.54723668342603	0.152084331942521	Prolactin signaling pathway: ESR1
hsa04917__65	0.122652265444155	UP	1.54443625503974	0.152827325444011	Prolactin signaling pathway: CYP17A1
hsa04024__77	0.123332431325243	DOWN	-1.54163582665345	0.153572987713805	cAMP signaling pathway: RHOA*
hsa05152__20	0.124701548409982	UP	1.53603496988086	0.155174973153878	Tuberculosis: FCGR1A
hsa04650__16	0.12539060699325	DOWN	-1.53323454149457	0.155826025489628	Natural killer cell mediated cytotoxicity: PRKCA
hsa04660__26	0.12539060699325	UP	1.53323454149457	0.155826025489628	T cell receptor signaling pathway: GRB2
hsa05161__92	0.125736223933692	UP	1.53183432730143	0.156152256954003	Hepatitis B: NFKBIA
hsa04931__47	0.126777529010214	DOWN	-1.52763368472199	0.157341464339625	Insulin resistance: AKT2*
hsa04210__3	0.128880265147243	DOWN	-1.51923239956312	0.159740117553872	Apoptosis: BCL2L1
hsa04611__25	0.128880265147243	UP	1.51923239956312	0.159740117553872	Platelet activation: ORAI1
hsa04740__37	0.133166924613622	UP	1.50242982924537	0.164835738701579	Olfactory transduction: CNGB1*
hsa05134__72	0.133166924613622	DOWN	-1.50242982924537	0.164835738701579	Legionellosis: IL12A
hsa04726__71	0.136085457613632	DOWN	-1.4912281157002	0.168337442301524	Serotonergic synapse: CACNA1A
hsa04976__16	0.136822751026417	UP	1.48842768731391	0.16913812445963	Bile secretion: CFTR
hsa04913__64	0.137192551608279	UP	1.48702747312076	0.169483763623902	Ovarian steroidogenesis: PLA2G4B
hsa05211__3	0.138306579390452	UP	1.48282683054133	0.170747741573363	Renal cell carcinoma: VEGFA
hsa04726__72	0.139053128363971	DOWN	-1.48002640215503	0.171556682991399	Serotonergic synapse: KCNJ3
hsa05133__60	0.139427564606449	DOWN	-1.47862618796189	0.17190577027265	Pertussis: C5
hsa04360__18	0.142070385549817	DOWN	-1.46882468860987	0.174934635942402	Axon guidance: PTK2
hsa05134__69	0.142070385549817	UP	1.46882468860987	0.174934635942402	Legionellosis: IL1B*
hsa05142__7	0.143981253417382	UP	1.46182361764414	0.177171431022437	Chagas disease (American trypanosomiasis): C1QA
hsa05152__82	0.14747123437343	DOWN	-1.44922168990583	0.181347152740625	Tuberculosis: IL6
hsa04917__37	0.148255428465951	UP	1.44642126151954	0.182192249893736	Prolactin signaling pathway: TNFSF11
hsa04024__12	0.149042803910561	UP	1.44362083313325	0.183040149377741	cAMP signaling pathway: SLC9A1
hsa05169__104	0.149437686736515	UP	1.4422206189401	0.183405234080935	Epstein-Barr virus infection: IRF3
hsa05150__69	0.151424085305019	UP	1.43521954797437	0.185721838308179	Staphylococcus aureus infection: FPR2
hsa04024__62	0.151823767728971	UP	1.43381933378123	0.185969269597612	cAMP signaling pathway: BAD
hsa05200__200	0.151823767728971	DOWN	-1.43381933378123	0.185969269597612	Pathways in cancer: FIGF
hsa04068__41	0.153027635327242	UP	1.42961869120179	0.187321776403835	FoxO signaling pathway: CDKN2B
hsa05164__35	0.15383423890483	UP	1.4268182628155	0.188186546160271	Influenza A: IL18
hsa04919__30	0.154238750711339	DOWN	-1.42541804862235	0.188558628878729	Thyroid hormone signaling pathway: MYH6
hsa04933__59	0.155457136016911	DOWN	-1.42121740604291	0.189924550439386	AGE-RAGE signaling pathway in diabetic complications: SERPINE1
hsa05145__9	0.159156130940602	DOWN	-1.4086154783046	0.19419114937493	Toxoplasmosis: MAPK1
hsa05223__24	0.159156130940602	DOWN	-1.4086154783046	0.19419114937493	Non-small cell lung cancer: STK4
hsa04930__7	0.160403814770682	DOWN	-1.40441483572517	0.195586481475737	Type II diabetes mellitus: C00002
hsa03320__23	0.162078874875847	DOWN	-1.39881397895258	0.197500782030945	PPAR signaling pathway: ACADL
hsa05200__202	0.162499695473586	UP	1.39741376475944	0.197629079478879	Pathways in cancer: FIGF*
hsa05200__223	0.162499695473586	UP	1.39741376475944	0.197629079478879	Pathways in cancer: CCND1****
hsa05221__17	0.162499695473586	UP	1.39741376475944	0.197629079478879	Acute myeloid leukemia: CCND1
hsa05152__69	0.162921339874604	UP	1.39601355056629	0.198013711270622	Tuberculosis: HLA-DMA
hsa05160__70	0.164191223732758	UP	1.39181290798685	0.199428125012186	Hepatitis C: CDKN1A
hsa04014__68	0.166324245768544	DOWN	-1.38481183702113	0.201758074757323	Ras signaling pathway: RALGDS*
hsa04151__35	0.166324245768544	UP	1.38481183702113	0.201758074757323	PI3K-Akt signaling pathway: CCND1
hsa04725__25	0.168911296960413	DOWN	-1.37641055186225	0.204764081928139	Cholinergic synapse: CACNA1A
hsa04650__119	0.170216089979835	DOWN	-1.37220990928281	0.206212787280535	Natural killer cell mediated cytotoxicity: KLRC4-KLRK1
hsa04932__138	0.1728483129496	DOWN	-1.36380862412394	0.209266739711533	Non-alcoholic fatty liver disease (NAFLD): CEBPA
hsa04115__40	0.177752909748147	UP	1.34840626799934	0.215066141285749	p53 signaling pathway: PIDD1
hsa05205__69	0.178203868807726	DOWN	-1.34700605380619	0.215473017689651	Proteoglycans in cancer: MAPK1*
hsa04910__12	0.180927517382649	DOWN	-1.33860476864732	0.218625598174919	Insulin signaling pathway: FASN
hsa04620__29	0.185535421325586	DOWN	-1.32460262671586	0.22390562406601	Toll-like receptor signaling pathway: CXCL8
hsa04742__34	0.185535421325586	UP	1.32460262671586	0.22390562406601	Taste transduction: GRM1
hsa04062__25	0.187871660855769	DOWN	-1.31760155575013	0.226579493419762	Chemokine signaling pathway: ROCK1
hsa04727__8	0.188341502739463	DOWN	-1.31620134155698	0.227000438516646	GABAergic synapse: ADCY1
hsa05142__49	0.189283785894576	DOWN	-1.31340091317069	0.227989893394813	Chagas disease (American trypanosomiasis): ADCY1
hsa04932__7	0.189756228508823	DOWN	-1.31200069897755	0.228412526180704	Non-alcoholic fatty liver disease (NAFLD): SREBF1
hsa04620__23	0.190229539372469	UP	1.3106004847844	0.228689254306378	Toll-like receptor signaling pathway: CD40
hsa05210__16	0.190229539372469	DOWN	-1.3106004847844	0.228689254306378	Colorectal cancer: MAPK8
hsa05211__27	0.19165468810866	UP	1.30639984220496	0.230255216723895	Renal cell carcinoma: VEGFA*
hsa05161__57	0.195977233400609	DOWN	-1.29379791446665	0.235297905149996	Hepatitis B: STAT3*
hsa04370__36	0.201851173243355	DOWN	-1.2769953441489	0.24219562868727	VEGF signaling pathway: NOS3
hsa04917__45	0.202346400979511	DOWN	-1.27559512995576	0.2426348994515	Prolactin signaling pathway: SLC2A2
hsa03320__29	0.203339511558407	UP	1.27279470156947	0.243670243761637	PPAR signaling pathway: OLR1
hsa05205__45 46	0.204835824255296	DOWN	-1.26859405899003	0.245306892145125	Proteoglycans in cancer: PAK1 FLNA
hsa05130__55	0.20583780426442	DOWN	-1.26579363060374	0.246349830708819	Pathogenic Escherichia coli infection: ACTB
hsa04210__61	0.210390788794449	DOWN	-1.25319170286543	0.251478557344001	Apoptosis: APAF1
hsa05222__40	0.210390788794449	UP	1.25319170286543	0.251478557344001	Small cell lung cancer: TRAF1
hsa05132__6	0.21090113954072	DOWN	-1.25179148867228	0.251928316082017	Salmonella infection: NFKB1
hsa04360__40 142	0.211924526039283	DOWN	-1.24899106028599	0.252989951987175	Axon guidance: UNC5D PTPN11
hsa05212__14	0.213466326736266	DOWN	-1.24479041770655	0.254668716150758	Pancreatic cancer: MAPK1
hsa04910__32	0.219188824157058	DOWN	-1.22938806158195	0.261329822710097	Insulin signaling pathway: EIF4E
hsa05016__55	0.222356221479355	DOWN	-1.22098677642308	0.264938072390431	Huntington's disease: TGM2
hsa04068__57	0.223419268265172	DOWN	-1.21818634803678	0.266035998143384	FoxO signaling pathway: IL7R
hsa04713__56	0.223952152890461	DOWN	-1.21678613384364	0.266501643623291	Circadian entrainment: KCNJ3
hsa04115__30	0.225020647116213	UP	1.21398570545735	0.26760366831099	p53 signaling pathway: SERPINE1
hsa04722__38	0.227168549355718	DOWN	-1.20838484868476	0.269987162706765	Neurotrophin signaling pathway: ATF4
hsa04071__48	0.228788955145374	DOWN	-1.20418420610533	0.271741116762426	Sphingolipid signaling pathway: SMPD1
hsa04612__17 28	0.229331029363572	UP	1.20278399191218	0.272041037988733	Antigen processing and presentation: CD4 HLA-DMA
hsa04917__47	0.229331029363572	DOWN	-1.20278399191218	0.272041037988733	Prolactin signaling pathway: INS
hsa04360__58	0.230962474490784	DOWN	-1.19858334933274	0.273803463449958	Axon guidance: PLXNC1
hsa04610__17	0.231508117783512	DOWN	-1.1971831351396	0.27410444443303	Complement and coagulation cascades: PLG
hsa04917__71	0.231508117783512	UP	1.1971831351396	0.27410444443303	Prolactin signaling pathway: CCND1*
hsa04340__49	0.232602149529541	DOWN	-1.19438270675331	0.275226346955924	Hedgehog signaling pathway: CCND1
hsa04261__15 17	0.234250066917696	DOWN	-1.19018206417387	0.277001809778697	Adrenergic signaling in cardiomyocytes: ACTC1 MYH6
hsa04115__52 53	0.23701494528511	DOWN	-1.18318099320814	0.279918970578706	p53 signaling pathway: CDK4 CCND1
hsa04933__29	0.23701494528511	UP	1.18318099320814	0.279918970578706	AGE-RAGE signaling pathway in diabetic complications: ICAM1
hsa04068__68	0.238127329218641	DOWN	-1.18038056482185	0.28087963063517	FoxO signaling pathway: ATG12
hsa05200__75	0.238127329218641	UP	1.18038056482185	0.28087963063517	Pathways in cancer: MAPK8
hsa04115__18	0.241486580315813	UP	1.17197927966297	0.284663290096244	p53 signaling pathway: CCNG1
hsa04650__110 111	0.242613708287966	UP	1.16917885127668	0.285812638164946	Natural killer cell mediated cytotoxicity: ITGAL ITGB2
hsa04742__49	0.244879050262163	DOWN	-1.1635779945041	0.288300586116919	Taste transduction: HTR1A
hsa04380__32	0.248879032238892	DOWN	-1.15377649515208	0.292826362916017	Osteoclast differentiation: AKT3
hsa03320__28	0.251763989587615	DOWN	-1.14677542418635	0.296035379496326	PPAR signaling pathway: ACSL1
hsa04115__34	0.252343768581562	UP	1.14537520999321	0.296531545443874	p53 signaling pathway: ZMAT3
hsa04211__52	0.255841984928914	UP	1.13697392483433	0.300454431050894	Longevity regulating pathway - mammal: PPARG
hsa05161__130	0.260558481123908	DOWN	-1.12577221128917	0.305802239869971	Hepatitis B: FASLG*
hsa05169__117	0.261746945312273	UP	1.12297178290287	0.307005312260775	Epstein-Barr virus infection: CDKN1A
hsa04210__72	0.264135099168991	UP	1.11737092613029	0.309613132463216	Apoptosis: BCL2A1
hsa04360__81	0.265334793579678	UP	1.114570497744	0.310825484498887	Axon guidance: FYN*
hsa04071__66	0.266538236054455	DOWN	-1.11177006935771	0.312040713736025	Sphingolipid signaling pathway: C01245
hsa04540__18 19	0.272000168385449	DOWN	-1.0991681416194	0.318236809711244	Gap junction: GJA1 GJA1***
hsa04390__14	0.272611746048889	DOWN	-1.09776792742625	0.31855564106086	Hippo signaling pathway: AREG
hsa04722__34	0.272611746048889	DOWN	-1.09776792742625	0.31855564106086	Neurotrophin signaling pathway: GSK3B
hsa04933__23	0.275683741936537	DOWN	-1.09076685646052	0.321945152951369	AGE-RAGE signaling pathway in diabetic complications: F3
hsa05205__195	0.280024079409495	DOWN	-1.0809653571085	0.326810711310833	Proteoglycans in cancer: CDKN1A
hsa04550__60	0.282525010798071	UP	1.07536450033592	0.32911624010513	Signaling pathways regulating pluripotency of stem cells: MAPK14
hsa05200__197	0.282525010798071	DOWN	-1.07536450033592	0.32911624010513	Pathways in cancer: CCND1**
hsa05212__19	0.282525010798071	DOWN	-1.07536450033592	0.32911624010513	Pancreatic cancer: MAPK8
hsa05150__14	0.283780979787942	UP	1.07256407194963	0.330374511165764	Staphylococcus aureus infection: FPR1
hsa04742__55	0.286936556230397	DOWN	-1.0655630009839	0.333841355515118	Taste transduction: P2RX3
hsa04010__129	0.29203806787603	DOWN	-1.05436128743873	0.339566540556349	MAPK signaling pathway: FOS
hsa04972__51	0.292679835090951	DOWN	-1.05296107324559	0.340102294456338	Pancreatic secretion: CLCA1
hsa04510__20 69	0.293966208466065	DOWN	-1.0501606448593	0.341385973861394	Focal adhesion: VASP ACTB
hsa04921__59	0.294610814889326	DOWN	-1.04876043066615	0.341712173566076	Oxytocin signaling pathway: CCND1
hsa05223__22	0.294610814889326	UP	1.04876043066615	0.341712173566076	Non-small cell lung cancer: BAD*
hsa04917__38	0.297198708391724	DOWN	-1.04315957389357	0.344501155501573	Prolactin signaling pathway: IRF1
hsa05014__32 34	0.299801755897271	DOWN	-1.03755871712098	0.347304253594927	Amyotrophic lateral sclerosis (ALS): NEFM PRPH
hsa05110__17	0.301763990348399	UP	1.03335807454155	0.349146882921577	Vibrio cholerae infection: C00698*
hsa05213__29	0.301763990348399	DOWN	-1.03335807454155	0.349146882921577	Endometrial cancer: CCND1
hsa04520__64	0.302419964010497	DOWN	-1.0319578603484	0.349475468865759	Adherens junction: CTNND1**
hsa05321__122	0.302419964010497	DOWN	-1.0319578603484	0.349475468865759	Inflammatory bowel disease (IBD): IL4**
hsa05200__198	0.303734755108747	DOWN	-1.02915743196211	0.35077910562344	Pathways in cancer: BCL2L1*
hsa04068__66	0.307701883895001	DOWN	-1.02075614680324	0.354924395235547	FoxO signaling pathway: BNIP3
hsa05222__34	0.307701883895001	DOWN	-1.02075614680324	0.354924395235547	Small cell lung cancer: CCND1
hsa04540__22	0.315063498904368	UP	1.00535379067863	0.362970309855616	Gap junction: C00547
hsa05222__39	0.31506363777249	DOWN	-1.00535379067863	0.362970309855616	Small cell lung cancer: BCL2L1
hsa04621__33 35	0.315738580443304	DOWN	-1.00395357648549	0.363524995498143	NOD-like receptor signaling pathway: NLRC4 PYCARD
hsa04115__56	0.316414471919279	UP	1.00255336229234	0.364080093531124	p53 signaling pathway: SESN3
hsa04152__63	0.320489745802661	UP	0.994152077133467	0.368543593857527	AMPK signaling pathway: PPARG
hsa05213__27	0.321855760744705	UP	0.991351648747176	0.36988805776104	Endometrial cancer: ELK1
hsa04724__65	0.323225292909868	DOWN	-0.988551220360884	0.371234917712495	Glutamatergic synapse: GRM3
hsa04340__26	0.324599175171955	DOWN	-0.985750791974593	0.372357661873079	Hedgehog signaling pathway: PTCH1**
hsa04550__25	0.324599175171955	DOWN	-0.985750791974593	0.372357661873079	Signaling pathways regulating pluripotency of stem cells: MAPK1
hsa04360__96	0.325287400374624	UP	0.984350577781447	0.372919478525881	Axon guidance: GSK3B
hsa05100__24	0.330131533655382	DOWN	-0.974549078429427	0.378242165694184	Bacterial invasion of epithelial cells: ACTB
hsa04015__92	0.330827038583276	UP	0.973148864236281	0.378808047226066	Rap1 signaling pathway: C00076*
hsa03320__42	0.334320626560457	UP	0.966147793270553	0.382342335549056	PPAR signaling pathway: ACOX1
hsa04610__45	0.334320626560457	DOWN	-0.966147793270553	0.382342335549056	Complement and coagulation cascades: C4A
hsa05217__19	0.33854383517218	DOWN	-0.957746508111678	0.386701438473268	Basal cell carcinoma: HHIP
hsa05321__83	0.33854383517218	UP	0.957746508111678	0.386701438473268	Inflammatory bowel disease (IBD): IL2
hsa03320__36	0.343513999839408	DOWN	-0.947945008759658	0.392140222173905	PPAR signaling pathway: SLC27A4
hsa05213__13	0.34494256410108	DOWN	-0.945144580373367	0.393531923464438	Endometrial cancer: CASP9
hsa04620__34	0.352142109636659	DOWN	-0.931142438441909	0.401501834955876	Toll-like receptor signaling pathway: IL1B
hsa04210__64	0.352867259856744	UP	0.929742224248764	0.402084646010202	Apoptosis: TNFRSF10D*
hsa05152__24 25	0.362380005359902	DOWN	-0.911539439737869	0.412673957618943	Tuberculosis: ITGB2 ITGAM
hsa05152__112	0.365339062393463	UP	0.905938582965286	0.415540011039538	Tuberculosis: IFNGR1
hsa05200__185	0.365339062393463	UP	0.905938582965286	0.415540011039538	Pathways in cancer: HHIP
hsa04724__13	0.369058927012735	UP	0.898937511999558	0.419517074323611	Glutamatergic synapse: GRM5
hsa04115__37	0.36980579952919	DOWN	-0.897537297806412	0.420111908896825	p53 signaling pathway: FAS
hsa05321__75	0.376569226362935	UP	0.8849353700681	0.427536904130486	Inflammatory bowel disease (IBD): IL10
hsa04723__67	0.382644791472904	DOWN	-0.873733656522935	0.433910418332883	Retrograde endocannabinoid signaling: PRKACA
hsa04919__89	0.382644791472904	UP	0.873733656522935	0.433910418332883	Thyroid hormone signaling pathway: CASP9
hsa04913__45	0.383408438983801	UP	0.872333442329789	0.434514147678264	Ovarian steroidogenesis: ACOT2
hsa04014__70	0.384173019074973	UP	0.870933228136643	0.435118205450196	Ras signaling pathway: RIN1*
hsa04068__50	0.385704975546124	DOWN	-0.868132799750352	0.436590150030824	FoxO signaling pathway: TNFSF10
hsa05200__201	0.388780063249803	DOWN	-0.862531942977769	0.439805983652245	Pathways in cancer: PDGFB
hsa04014__65	0.39887672503698	DOWN	-0.844329158466874	0.450956297439521	Ras signaling pathway: MLLT4*
hsa04012__21	0.400443949576748	DOWN	-0.841528730080583	0.452455911758694	ErbB signaling pathway: GSK3B
hsa05200__220	0.410720800433838	UP	0.823325945569688	0.463788692316816	Pathways in cancer: CSF1R*
hsa04623__17	0.413114439557185	UP	0.819125302990251	0.465931591793488	Cytosolic DNA-sensing pathway: NFKB1
hsa04728__36	0.413114439557185	UP	0.819125302990251	0.465931591793488	Dopaminergic synapse: TH
hsa05200__66	0.413914151793914	UP	0.817725088797105	0.466553504031652	Pathways in cancer: CCND1
hsa04024__107 64	0.416318778818052	DOWN	-0.813524446217668	0.468982605155348	cAMP signaling pathway: NFKBIA NFKB1
hsa04213__53	0.421152691299718	UP	0.805123161058794	0.474143742931198	Longevity regulating pathway - multiple species: SOD1
hsa04360__51	0.423581947233612	UP	0.800922518479357	0.476307886805479	Axon guidance: FYN
hsa05223__9	0.423581947233612	UP	0.800922518479357	0.476307886805479	Non-small cell lung cancer: BAD
hsa04360__101 103	0.424393517652476	DOWN	-0.799522304286211	0.476935059610647	Axon guidance: DPYSL2 DPYSL5
hsa04064__130	0.425205996338569	UP	0.798122090093065	0.477562502761609	NF-kappa B signaling pathway: TNF*
hsa04330__19	0.430099909390835	UP	0.789720804934191	0.482770447876571	Notch signaling pathway: DTX2
hsa04917__33	0.43091872952108	DOWN	-0.788320590741045	0.483400771803051	Prolactin signaling pathway: CSN2
hsa05140__21	0.435026370721814	DOWN	-0.781319519775316	0.487717512282989	Leishmaniasis: NFKB1
hsa05110__14	0.435850602729291	UP	0.779919305582171	0.487768482744692	Vibrio cholerae infection: C00238*
hsa05110__15	0.435850602729291	UP	0.779919305582171	0.487768482744692	Vibrio cholerae infection: C01330
hsa05110__16	0.435850602729291	UP	0.779919305582171	0.487768482744692	Vibrio cholerae infection: C00698
hsa04666__51	0.436675734525332	DOWN	-0.778519091389025	0.488401014983987	Fc gamma R-mediated phagocytosis: NCF1
hsa04962__10	0.437501765472691	DOWN	-0.777118877195879	0.489033799716351	Vasopressin-regulated water reabsorption: AQP2
hsa05215__24	0.439985246786884	DOWN	-0.772918234616442	0.491517407082375	Prostate cancer: CDKN1A
hsa04350__44 45	0.442476797116673	DOWN	-0.768717592037005	0.49400707176603	TGF-beta signaling pathway: TGFBR2 TGFBR1
hsa05132__54	0.443309094580349	UP	0.767317377843859	0.494642392349452	Salmonella infection: IL1B
hsa04725__54	0.449999681587955	DOWN	-0.756115664298693	0.501809733948823	Cholinergic synapse: CHRM1*
hsa05162__105	0.453366313781989	UP	0.75051480752611	0.505264118384554	Measles: GSK3B
hsa04670__10	0.455054945864586	DOWN	-0.747714379139819	0.506845431700982	Leukocyte transendothelial migration: BCAR1
hsa05200__213	0.456747114193149	UP	0.744913950753528	0.508428807801497	Pathways in cancer: CSF2RA
hsa04917__68	0.457594522610762	DOWN	-0.743513736560382	0.509070519825709	Prolactin signaling pathway: CCND1
hsa04923__31	0.458442812874713	UP	0.742113522367236	0.50971245289443	Regulation of lipolysis in adipocytes: PRKACA*
hsa05160__58	0.460142035948587	DOWN	-0.739313093980945	0.511299163540743	Hepatitis C: EIF3E
hsa04010__62	0.462697465589301	DOWN	-0.735112451401507	0.513834833240128	MAPK signaling pathway: MEF2C
hsa05221__6	0.463551031091877	DOWN	-0.733712237208362	0.514478669475272	Acute myeloid leukemia: CEBPA
hsa04330__12	0.469550488568027	DOWN	-0.723910737856342	0.520829615123567	Notch signaling pathway: HES1
hsa05145__10	0.471272470223112	DOWN	-0.72111030947005	0.522431251651462	Toxoplasmosis: MAPK8
hsa04114__56	0.473861961032116	DOWN	-0.716909666890613	0.524992113667067	Oocyte meiosis: REC8
hsa03320__58	0.474726859583175	DOWN	-0.715509452697467	0.525330841670663	PPAR signaling pathway: CYP8B1
hsa05010__49	0.474726859583175	DOWN	-0.715509452697467	0.525330841670663	Alzheimer's disease: EIF2AK3
hsa04728__60	0.477326748494275	DOWN	-0.71130881011803	0.527896974938636	Dopaminergic synapse: CACNA1A
hsa04961__26	0.479064327112294	UP	0.708508381731739	0.529506982731765	Endocrine and other factor-regulated calcium reabsorption: TRPV5*
hsa05031__11	0.481677157123189	UP	0.704307739152301	0.531769317411559	Amphetamine addiction: GRIN3A
hsa05031__54	0.481677157123189	UP	0.704307739152301	0.531769317411559	Amphetamine addiction: GRIN3A*
hsa04530__20 62	0.492205579642245	DOWN	-0.687505168834553	0.543073566733869	Tight junction: ACTB SHROOM1
hsa04660__30	0.502856201975636	UP	0.670702598516804	0.554499297835809	T cell receptor signaling pathway: CD40LG
hsa04068__14	0.504643073545901	UP	0.667902170130512	0.556143305098386	FoxO signaling pathway: G6PC
hsa05164__41 42	0.51002370773735	DOWN	-0.659500884971638	0.561743579623963	Influenza A: STAT1 IRF9
hsa05162__27 70	0.511823899352014	UP	0.656700456585347	0.563396079017243	Measles: STAT1 GNB2L1
hsa05210__23	0.513627401103691	UP	0.653900028199055	0.565050284937843	Colorectal cancer: CCND1
hsa04662__10	0.51815058412271	UP	0.646898957233327	0.569692772127895	B cell receptor signaling pathway: GSK3B
hsa04666__40	0.51996560726203	UP	0.644098528847035	0.571354021079155	Fc gamma R-mediated phagocytosis: PLA2G6
hsa04540__12	0.520874346818494	DOWN	-0.642698314653889	0.572018058253624	Gap junction: C00025
hsa05110__13	0.52543022309382	UP	0.635697243688161	0.576684222659631	Vibrio cholerae infection: C00238
hsa03320__62	0.53184263970733	UP	0.625895744336141	0.583381389381246	PPAR signaling pathway: UBC
hsa04742__37	0.539218735399186	DOWN	-0.614694030790975	0.591127190090473	Taste transduction: P2RY4
hsa05160__22 23	0.551314763880801	UP	0.59649124628008	0.604035242759199	Hepatitis C: STAT1 IRF9
hsa04724__5 71	0.552250668642249	UP	0.595091032086935	0.604708045675283	Glutamatergic synapse: GRIN3A DLG4
hsa05134__6	0.561652467661587	UP	0.581088890155477	0.614644721453769	Legionellosis: IL1B
hsa04550__22	0.566382208415483	DOWN	-0.574087819189749	0.619459935746619	Signaling pathways regulating pluripotency of stem cells: SMAD2
hsa04066__26	0.569229194781331	DOWN	-0.569887176610312	0.621849800577977	HIF-1 signaling pathway: C01245
hsa05162__27 28	0.569229194781331	DOWN	-0.569887176610312	0.621849800577977	Measles: STAT1 IRF9
hsa05321__74	0.570179706392635	DOWN	-0.568486962417166	0.622526245387427	Inflammatory bowel disease (IBD): IL5
hsa04750__60	0.573989111551655	UP	0.562886105644583	0.626321452151892	Inflammatory mediator regulation of TRP channels: TRPV3
hsa03320__8	0.57876817729121	DOWN	-0.555885034678854	0.631169706982115	PPAR signaling pathway: GK
hsa04668__138	0.584527382308534	UP	0.54748374951998	0.637080598235345	TNF signaling pathway: NFKB1*
hsa04064__93	0.590313104003327	DOWN	-0.539082464361105	0.643013520244783	NF-kappa B signaling pathway: PLAU
hsa04670__28 41 49	0.591279948804314	UP	0.53768225016796	0.643693524799134	Leukocyte transendothelial migration: ACTB CTNNA1 CTNNB1
hsa04725__53	0.592247414597341	DOWN	-0.536282035974814	0.644373417503418	Cholinergic synapse: CHRNA7
hsa05152__23	0.59612505423558	DOWN	-0.530681179202231	0.648217000525842	Tuberculosis: PPP3CA
hsa04920__12	0.597096212023117	UP	0.529280965009085	0.648522450227045	Adipocytokine signaling pathway: C00165
hsa04932__95	0.597096242093022	UP	0.529280965009085	0.648522450227045	Non-alcoholic fatty liver disease (NAFLD): IL1A
hsa04024__44 67	0.598068149018205	DOWN	-0.52788075081594	0.649202803007053	cAMP signaling pathway: CREB3 CREBBP
hsa04010__88 92	0.602938421417709	UP	0.520879679850211	0.654111601526487	MAPK signaling pathway: ECSIT TRAF6
hsa04068__53	0.605869125111614	DOWN	-0.516679037270774	0.656911763464929	FoxO signaling pathway: SOD2
hsa04210__24	0.606847441334055	UP	0.515278823077628	0.657214030124893	Apoptosis: CASP10
hsa05152__77	0.606847441334055	UP	0.515278823077628	0.657214030124893	Tuberculosis: IL12A
hsa05164__47	0.608806187818473	UP	0.512478394691337	0.658955545455594	Influenza A: CIITA
hsa04360__6	0.618641831064906	DOWN	-0.498476252759879	0.669215889793298	Axon guidance: MAPK1
hsa04933__62	0.620617261406334	UP	0.495675824373588	0.670966532901324	AGE-RAGE signaling pathway in diabetic complications: AGER**
hsa04932__14	0.622595431875651	UP	0.492875395987296	0.672718123343501	Non-alcoholic fatty liver disease (NAFLD): PKLR
hsa04742__54	0.627552634938233	DOWN	-0.485874325021568	0.677295462980437	Taste transduction: P2RX2*
hsa04742__40	0.627552634938233	DOWN	-0.485874325021568	0.677295462980437	Taste transduction: P2RX2
hsa05205__434	0.62854626641402	DOWN	-0.484474110828422	0.677978435471839	Proteoglycans in cancer: CASP3
hsa04024__116	0.632526973382178	DOWN	-0.478873254055839	0.681880770502073	cAMP signaling pathway: ACOX1
hsa05168__138	0.633523821910934	UP	0.477473039862693	0.68256379665748	Herpes simplex infection: CHUK
hsa04370__15	0.640520316329422	UP	0.467671540510673	0.689706403657871	VEGF signaling pathway: PLA2G4B
hsa05168__29	0.641522447926626	UP	0.466271326317528	0.690389850890109	Herpes simplex infection: IKBKG
hsa04211__62	0.650570854198944	DOWN	-0.453669398579216	0.699726751596918	Longevity regulating pathway - mammal: EHMT2
hsa04071__69	0.656631972601115	DOWN	-0.445268113420342	0.70584180578804	Sphingolipid signaling pathway: RAC1
hsa05130__26	0.657644373305857	DOWN	-0.443867899227196	0.706525887616755	Pathogenic Escherichia coli infection: CTNNB1
hsa04723__10	0.663731918321841	UP	0.435466614068322	0.712251441762844	Retrograde endocannabinoid signaling: CACNA1A
hsa04723__21	0.663731918321841	UP	0.435466614068322	0.712251441762844	Retrograde endocannabinoid signaling: CACNA1A*
hsa05231__59	0.664748684300724	DOWN	-0.434066399875176	0.712935375457226	Choline metabolism in cancer: PLA2G4B
hsa04727__13	0.665766067446062	DOWN	-0.43266618568203	0.713619190377154	GABAergic synapse: CACNA1A
hsa04370__37	0.667802678747603	DOWN	-0.429865757295739	0.715394089718783	VEGF signaling pathway: CASP9
hsa04510__43	0.678022210645536	UP	0.415863615364281	0.725928053448981	Focal adhesion: BAD
hsa04710__5	0.679047468190352	DOWN	-0.414463401171136	0.726611727067011	Circadian rhythm: RORA
hsa04550__101	0.688301322538568	DOWN	-0.401861473432824	0.736094584547507	Signaling pathways regulating pluripotency of stem cells: ESRRB
hsa04350__32	0.692429274580695	DOWN	-0.396260616660241	0.740087944787899	TGF-beta signaling pathway: RPS6KB1
hsa04210__73	0.69553125289782	DOWN	-0.392059974080804	0.742980798291645	Apoptosis: TRAF1
hsa05164__34	0.703828020154933	DOWN	-0.380858260535638	0.751416391972227	Influenza A: IL1B
hsa05150__35	0.706948312144852	DOWN	-0.376657617956201	0.754319067870629	Staphylococcus aureus infection: FCAR
hsa04071__57	0.707989736954023	UP	0.375257403763055	0.755001541280709	Sphingolipid signaling pathway: BAX
hsa03320__26	0.711116766176243	UP	0.371056761183618	0.757906071267816	PPAR signaling pathway: CPT2
hsa05016__12	0.712160193517726	DOWN	-0.369656546990472	0.75858787053277	Huntington's disease: REST
hsa04068__46	0.715293703617668	UP	0.365455904411035	0.761062779783465	FoxO signaling pathway: PLK4
hsa05219__12	0.715293703617668	UP	0.365455904411035	0.761062779783465	Bladder cancer: ERBB2
hsa04015__27	0.718432018582174	UP	0.361255261831598	0.763969305555124	Rap1 signaling pathway: RALA
hsa04530__14 20 43	0.719479183012531	UP	0.359855047638452	0.764650104570445	Tight junction: CTNNA1 ACTB ACTN4
hsa05145__29	0.724722843425307	UP	0.352853976672724	0.769352696977903	Toxoplasmosis: C06314
hsa04960__13	0.724722870490095	UP	0.352853976672724	0.769352696977903	Aldosterone-regulated sodium reabsorption: FXYD4
hsa05014__31 34	0.726823982426221	UP	0.350053548286432	0.771147522856505	Amyotrophic lateral sclerosis (ALS): NEFL PRPH
hsa05223__37	0.731032361616222	UP	0.344452691513849	0.775174834919233	Non-small cell lung cancer: CCND1*
hsa05200__191	0.732085728188299	UP	0.343052477320703	0.775853966872991	Pathways in cancer: CCND1*
hsa04360__82	0.734193974716717	UP	0.340252048934412	0.777649649657673	Axon guidance: ILK
hsa05152__90	0.736304200890977	UP	0.337451620548121	0.779445404774166	Tuberculosis: CR1
hsa04810__23	0.737360100551825	DOWN	-0.336051406354975	0.779684653312819	Regulation of actin cytoskeleton: GSN
hsa05205__369	0.737360100551825	UP	0.336051406354975	0.779684653312819	Proteoglycans in cancer: HOXD10
hsa04152__35	0.739473333745591	UP	0.333250977968683	0.781479411759261	AMPK signaling pathway: PFKFB1
hsa04150__33	0.743705692176638	DOWN	-0.3276501211961	0.785510396627264	mTOR signaling pathway: RPS6
hsa04666__49	0.74582478783132	UP	0.324849692809809	0.787306054120815	Fc gamma R-mediated phagocytosis: ARF6*
hsa04610__44	0.753256680145051	DOWN	-0.315048193457789	0.794258867560354	Complement and coagulation cascades: C3
hsa04910__46	0.753256680145051	DOWN	-0.315048193457789	0.794258867560354	Insulin signaling pathway: FBP1
hsa04330__11	0.754320266196973	UP	0.313647979264643	0.794934256973703	Notch signaling pathway: PTCRA
hsa05140__43	0.755384318408027	DOWN	-0.312247765071497	0.795609380206661	Leishmaniasis: MAPK14
hsa04115__23	0.756448834895434	UP	0.310847550878352	0.796284235724661	p53 signaling pathway: PTEN
hsa03320__21	0.758579253154986	UP	0.30804712249206	0.797633137480817	PPAR signaling pathway: ACAA1
hsa05215__35	0.758579253154986	UP	0.30804712249206	0.797633137480817	Prostate cancer: CASP9
hsa05205__189	0.7596451511484	UP	0.306646908298915	0.79786094969695	Proteoglycans in cancer: IL12B
hsa05216__15	0.7596451511484	UP	0.306646908298915	0.79786094969695	Thyroid cancer: CCND1
hsa05215__46	0.763913291339279	UP	0.301046051526332	0.80189557230531	Prostate cancer: MTOR
hsa05223__14	0.768188617396144	DOWN	-0.295445194753749	0.805933228412817	Non-small cell lung cancer: CCND1
hsa04530__6 11 45	0.775687360945079	DOWN	-0.285643695401729	0.813346289740962	Tight junction: CLDN24 TJP1 TJP2
hsa05200__215	0.777833740135428	DOWN	-0.282843267015437	0.815141995378957	Pathways in cancer: CSF1R
hsa04742__8	0.783207041986772	UP	0.275842196049708	0.820315513875778	Taste transduction: PLCB2
hsa04151__27	0.785359325855833	DOWN	-0.273041767663417	0.821653771315763	PI3K-Akt signaling pathway: FASLG
hsa05168__92 93	0.785359325855833	DOWN	-0.273041767663417	0.821653771315763	Herpes simplex infection: IRF9 STAT1
hsa04742__47	0.792905005981499	UP	0.263240268311397	0.82908653658277	Taste transduction: GABRA1
hsa04115__16	0.793984586866719	UP	0.261840054118251	0.829753636664386	p53 signaling pathway: PPM1D
hsa05134__59	0.805885370930023	UP	0.246437697993648	0.841722407991948	Legionellosis: HSPA1A
hsa04520__43	0.806969538099333	UP	0.245037483800502	0.842386534493692	Adherens junction: ACTB
hsa05162__44	0.808054076252367	UP	0.243637269607357	0.843050310537589	Measles: PRKCQ
hsa04933__25	0.809138983388999	UP	0.242237055414211	0.843713734621492	AGE-RAGE signaling pathway in diabetic complications: IL1A
hsa04340__46	0.813482261694755	DOWN	-0.236636198641628	0.847302200512442	Hedgehog signaling pathway: PRKACA
hsa04662__29	0.813482261694755	DOWN	-0.236636198641628	0.847302200512442	B cell receptor signaling pathway: RAC1
hsa04728__64	0.816743496431582	DOWN	-0.232435556062191	0.850227717337919	Dopaminergic synapse: SCN1A
hsa04151__97	0.818919420815428	DOWN	-0.229635127675899	0.851549303659208	PI3K-Akt signaling pathway: MCL1
hsa05142__84	0.818919420815428	UP	0.229635127675899	0.851549303659208	Chagas disease (American trypanosomiasis): NFKB1*
hsa04722__33	0.820007907318528	DOWN	-0.228234913482754	0.852209545271856	Neurotrophin signaling pathway: BAD
hsa05212__31	0.823275439791544	UP	0.224034270903317	0.855132421983589	Pancreatic cancer: RAC1*
hsa05168__91 92	0.825455501969235	DOWN	-0.221233842517025	0.85692314265204	Herpes simplex infection: STAT1 IRF9
hsa05200__65	0.829819650430372	UP	0.215632985744442	0.860977980761275	Pathways in cancer: STK4
hsa04340__14	0.837469480561642	DOWN	-0.205831486392422	0.868435515438922	Hedgehog signaling pathway: PTCH1
hsa05164__70	0.845134706752924	DOWN	-0.196029987040402	0.875417923918822	Influenza A: RNASEL
hsa05168__83	0.845134706752924	DOWN	-0.196029987040402	0.875417923918822	Herpes simplex infection: RNASEL
hsa05133__59	0.849521476673263	UP	0.190429130267819	0.879477054914083	Pertussis: C3
hsa05321__81	0.850618903096127	DOWN	-0.189028916074673	0.880128259315872	Inflammatory bowel disease (IBD): IL13
hsa04919__42	0.85720946693475	DOWN	-0.180627630915799	0.886459322163124	Thyroid hormone signaling pathway: SLC2A1
hsa05200__218	0.858308875706253	UP	0.179227416722653	0.887108018400467	Pathways in cancer: CSF3R*
hsa04530__20 31	0.859408559338391	UP	0.177827202529508	0.887756285319866	Tight junction: ACTB MLLT4
hsa05166__33	0.861699834202159	DOWN	-0.168025703177487	0.889634059596625	HTLV-I infection: HLA-A
hsa04360__21	0.862709238512099	UP	0.17362655995007	0.890187072577833	Axon guidance: PAK4
hsa05212__29	0.863810000692372	DOWN	-0.172226345756925	0.890833694457172	Pancreatic cancer: VEGFA
hsa05016__48	0.869317735741092	UP	0.165225274791196	0.895530715711355	Huntington's disease: HIP1
hsa05016__46	0.869317735741092	UP	0.165225274791196	0.895530715711355	Huntington's disease: HTT**
hsa05152__6	0.871522621846391	DOWN	-0.162424846404905	0.897310140520202	Tuberculosis: IL10
hsa05032__37	0.879247478219493	UP	0.152623347052884	0.904767804805272	Morphine addiction: KCNJ3
hsa04660__43	0.880351985758527	UP	0.151223132859739	0.904913228249602	T cell receptor signaling pathway: RHOA
hsa04915__58	0.880351985758527	UP	0.151223132859739	0.904913228249602	Estrogen signaling pathway: CREB3***
hsa04921__65	0.883666896797646	UP	0.147022490280301	0.907824001685499	Oxytocin signaling pathway: TRPM2
hsa05200__76	0.895838571738704	DOWN	-0.131620134155698	0.919825506173238	Pathways in cancer: RAC1
hsa04024__92	0.911364952651309	DOWN	-0.112017135451658	0.934746040410376	cAMP signaling pathway: GRIN3A
hsa05215__14	0.911364952651309	DOWN	-0.112017135451658	0.934746040410376	Prostate cancer: CCND1
hsa04360__89	0.913585913400343	DOWN	-0.109216707065367	0.936512783021956	Axon guidance: CAMK2A
hsa05014__2	0.915807549185852	DOWN	-0.106416278679075	0.938278290578089	Amyotrophic lateral sclerosis (ALS): SLC1A2
hsa05169__83	0.919141230877964	UP	0.102215636099638	0.941180584642885	Epstein-Barr virus infection: GSK3B
hsa04024__60	0.920252776958872	UP	0.100815421906492	0.941805538075011	cAMP signaling pathway: PDE3A
hsa05169__64	0.922476334454527	DOWN	-0.098014993520201	0.943567246837265	Epstein-Barr virus infection: NFKB2
hsa04064__54	0.92581280164828	UP	0.0938143509407638	0.946464773828683	NF-kappa B signaling pathway: CCL13
hsa04012__31	0.930263444912382	DOWN	-0.0882134941681809	0.950497560081765	ErbB signaling pathway: BAD
hsa04152__27	0.93248959346159	UP	0.0854130657818894	0.952254318540395	AMPK signaling pathway: ADIPOR1
hsa04012__3	0.938057237672851	DOWN	-0.0784119948161608	0.957419635843176	ErbB signaling pathway: ELK1
hsa04064__114	0.941399295959051	UP	0.0742113522367236	0.960309053804048	NF-kappa B signaling pathway: BCL2A1*
hsa05142__44	0.943627911864287	UP	0.0714109238504322	0.962060144543133	Chagas disease (American trypanosomiasis): PLCB1
hsa05166__83	0.946971657826966	UP	0.067210281270995	0.964945631809582	HTLV-I infection: NFKB2
hsa04151__37	0.948086450343283	DOWN	-0.0658100670778492	0.965557962165327	PI3K-Akt signaling pathway: G6PC
hsa04012__8	0.949201344497498	DOWN	-0.0644098528847035	0.96616973256273	ErbB signaling pathway: STAT5A
hsa04662__27	0.95031633811282	UP	0.0630096386915578	0.966257791836574	B cell receptor signaling pathway: NFATC1
hsa05150__13	0.95031633811282	DOWN	-0.0630096386915578	0.966257791836574	Staphylococcus aureus infection: C5AR1
hsa04933__57	0.952546615016708	DOWN	-0.0602092103052663	0.968001670966141	AGE-RAGE signaling pathway in diabetic complications: FIGF
hsa04068__48	0.953661893948822	DOWN	-0.0588089961121206	0.968611188502614	FoxO signaling pathway: FASLG
hsa04015__3	0.968167984290626	UP	0.0406062116012261	0.982813421114039	Rap1 signaling pathway: MAPK1
hsa05222__19	0.970400746258822	UP	0.0378057832149347	0.984548057354388	Small cell lung cancer: CASP9
hsa04724__52	0.971517215344223	UP	0.0364055690217889	0.985148865424606	Glutamatergic synapse: CACNA1A
hsa04623__8	0.974866948772135	DOWN	-0.0322049264423518	0.988012403852665	Cytosolic DNA-sensing pathway: TBK1
hsa04151__51	0.975983628016388	DOWN	-0.030804712249206	0.988610909457031	PI3K-Akt signaling pathway: NOS3
hsa03320__66	0.990503945256344	UP	0.0126019277383116	1	PPAR signaling pathway: UCP1
hsa05162__58	0.99385540966153	UP	0.00840128515887437	1	Measles: STAT3
hsa04910__9	0.998324187302307	UP	0.00280042838629146	1	Insulin signaling pathway: ELK1
hsa04152__33	1	0	0	1	AMPK signaling pathway: CPT1C
hsa04152__41	1	0	0	1	AMPK signaling pathway: FBP1
hsa04211__2	1	0	0	1	Longevity regulating pathway - mammal: RPS6KB1
hsa04911__41	1	0	0	1	Insulin secretion: ABCC8
hsa04911__35	1	0	0	1	Insulin secretion: TRPM4
hsa04922__67	1	0	0	1	Glucagon signaling pathway: FBP1
hsa04922__60	1	0	0	1	Glucagon signaling pathway: CPT1C*
hsa04924__34	1	0	0	1	Renin secretion: REN
hsa04924__47	1	0	0	1	Renin secretion: KCNMA1
hsa04931__151	1	0	0	1	Insulin resistance: CPT1A
hsa04931__29	1	0	0	1	Insulin resistance: CPT1B
hsa04960__15	1	0	0	1	Aldosterone-regulated sodium reabsorption: C00762
hsa05030__13	1	0	0	1	Cocaine addiction: SLC6A3
hsa05031__15	1	0	0	1	Amphetamine addiction: MAOA
hsa05031__77	1	0	0	1	Amphetamine addiction: MAOA*
hsa05034__7	1	0	0	1	Alcoholism: GRIN3A
hsa05034__75	1	0	0	1	Alcoholism: SLC29A1
hsa05140__37	1	0	0	1	Leishmaniasis: ELK1
hsa05140__55	1	0	0	1	Leishmaniasis: JUN
hsa05140__41 57	1	0	0	1	Leishmaniasis: NOS2 CYBA
hsa05211__12	1	0	0	1	Renal cell carcinoma: EGLN2